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Antibiotic Stewardship
2016 Nurse Practitioner Association
of South Dakota Conference
September 30, 2016
Presented by:
James M. Keegan, MD
Randee Mason, RN, BSN, CPHQ
Prepared for West Virginia Hospital Association
August 14, 2015
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PYA ASP TEAM
JAMES M. KEEGAN, MD
Principal
RANDEE MASON, RN, BSN, CPHQ
Senior Manager
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James M. Keegan, MD
Personal History
1986-2005:
Clinical Practice Infectious Disease
1990-Present: Medical Director of Infection Control, Rapid City Regional
Hospital and Regional Health (Western SD)
2000- 2015:
Medical Director Antibiotic Stewardship, Rapid City Regional
Hospital
2005-2013:
Administrative Leadership in Regional Health
Vice President Quality  Chief Medical Officer  Chief Executive Officer of
Regional Health Physicians
2015- :
Principal at PYA Healthcare Consulting
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Antibiotic Stewardship
The
Zoo
In
You
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Human Microbiome
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Human Microbiome
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Human Microbiome
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Human Microbiome
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Human Microbiome
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Human Microbiome
AMA Morning Rounds September 26, 2016
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Human Microbiome
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Human Microbiome
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Human Microbiome
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Antibiotic Stewardship
“…resistance to antibiotics has become a major threat to public health”
World Health Organization1
“Dangerous infections that are resistant to antibiotics are spreading and
growing stronger, with dire consequences”
Consumer Reports2
“We can either work to improve antibiotic use and
prevent infections, or watch as the clock turns back
to a world where simple infections kill people”
Tom Frieden, CDC, Wall Street Journal3
1 Bulletin
of the World Health Organization, http://cx.dol.org/10.2471/BLT.11.088435.
2015 Consumer Reports, Vol. 80 No. 8.
3 June, 2015 Wall Street Journal.
2 August
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Antibiotic Stewardship
Infectious Diseases Society of America (IDSA)
&
Society for Healthcare Epidemiology of America
(SHEA) recommend antibiotic stewardship as a
condition of participation
by
December 2017
to
Centers for Medicare & Medicaid Services (CMS)4
4
IDSA and SHEA letter to CMS, March 4, 2014.
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Quinolones
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MRSA
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MRSA by Country
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Antibiotic Stewardship
Antibiotic prescribing in hospitals are often:
Inconsistent
Inappropriate
Contributes to Antibiotic Resistance
CDC7
7
Centers for Disease Control and Prevention, CDC, “Core Elements of Hospital Antibiotic Stewardship Programs.”
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Antibiotic Stewardship
“At community hospitals, one of three patients
with bloodstream infections receives inappropriate,
empiric antimicrobial therapy…”
Duke University8
8
Duke TODAY, Health and Medicine, March 18, 2014.
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Antibiotic Stewardship
“Patients getting powerful antibiotics to treat a broad range of infections are
up to three times more likely to get another infection
from an even more resistant microbe.”
Thomas Frieden, Director of CDC9
Federal data cite at least 2
million Americans are infected
with drug-resistant bacteria each year 23,000 Die as a Result10
9
CDC
Ibid.
10
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Human Microbiome
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Antibiotic Stewardship
 If you are hospitalized and declare a penicillin
allergy, your mortality risk doubles if you are
prescribed an alternative medication
 Avoiding penicillin means using alternatives that are
less effective, more expensive or have
greater side effects
 An allergist can confirm your suspected “allergy” to
penicillin with a simple skin test
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Leadership
Commitment
Ongoing
Education
Reporting
Accountability
The CDC
Recommended Core
Elements for
Successful Antibiotic
Use13
Tracking
13
Drug Expertise
Active
Oversight
Centers for Disease Control and Prevention, CDC, “Core Elements of Hospital Antibiotic Stewardship Programs.”
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ASP Safety Bundle
Manage
Chronic Diseases
Prevention
Wellness
Appropriate
Antibiotic
prescribing
Wash
Hands
Annual Flu Shot
3-Foot Rule and avoid
large crowds during
flu season
Penicillin
Allergy
Testing
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Antibiotic Stewardship
 Cost Savings: soft savings or unrealized savings
 Avoid Unnecessary Admissions
 Decreased LOS (Length of Stay)
 Decreased Readmissions
 Decreased risk for HAI (Hospital Acquired Infections)
 Decreased “Never” Events
 Improved DRG Sufficiency
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Antibiotic Stewardship
Rapid City Regional Hospital (RCRH)
417 Licensed beds
Ernst & Young ~$1 million antibiotic per year cost savings
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Western South Dakota
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Methicillin Resistant Staphylococcus
Aureus
RAPID CITY REGIONAL HOSPITAL RESULTS
MRSA (STAPHYLOCOCCUS AUREUS BACTERIA)
SEPSIS TWICE THE MORTALITY RATE
OF SENSITIVE STAPH SEPSIS
Baseline
Peak
Current
National
Average
15%
50%
35%
60-70%
MRSA
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RAPID CITY REGIONAL HOSPITAL RESULTS
THE CAUSE OF 75% OF BACTERIAL PNEUMONIAS
Baseline
Peak
Current
National
Average
0%
25%
0%
5-10%
Streptococcus
Pneumoniae
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Carbapenem Resistant Enterobacteriaceae
RAPID CITY REGIONAL HOSPITAL RESULTS
CURRENTLY NO EFFECTIVE DEPENDABLE TREATMENT
CRE
Baseline
Peak
Current
National
Average
None
None
None
Rising
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Clostridium Difficile
RAPID CITY REGIONAL HOSPITAL
HOSPITAL ACQUIRED INFECTION
1/10 DIE WITH THIS DIAGNOSIS
C- diff
Baseline
Peak
Current
National
Average
1/10-1/2
Nat. Ave
Same
Same
Nat. Ave.
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Valley Hospital ASP Results
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PRIMUM NON NOCERE:
Aggressive Diagnostics
&
Conservative Therapeutics
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Contact Information
James M. Keegan, MD
[email protected]
Randee Mason, RN, BSN, CPHQ
[email protected]
www.pyapc.com
(800) 270-9629
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