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Clinical Data Collection 24 / 7 New York Genome Center ALS signature ALS Knowledge Network GUID Sequencing Genomics -OMICs Anonymized volunteer participants MD Clinics Cedars-Sinai Medical Center • Johns Hopkins University • Massachusetts General Hospital • Ohio State University • Emory University • Washington University • Cedars-Sinai Medical Center Cell biology + IPSCs Biobanking • Cell imaging • Transcriptomics • Metabolomics • Proteomics • Epigenomics - PBMCs Gladstone University of California Irvine Cedars-Sinai Medical Center Cedars-Sinai Medical Center Massachusetts Institute of Technology iPSCs Motor neurons Mass General Blood BioBanking + Optional CSF BioBanking Advanced Big Data Analytics Secure Global Research Community