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SCIENTIFIC PROGRAM
www.ici2013.org
Week-at-a-glance
THURSDAY, AUGUST 22
FRIDAY, AUGUST 23
SATURDAY, AUGUST 24
SUNDAY, AUGUST 25
MONDAY, AUGUST 26
TUESDAY, AUGUST 27
Registration
Registration
Registration
Registration
Registration
07:00-08:00
08:00-08:45
Clinical Immunology Course Clinical Immunology Course Clinical Immunology Course Clinical Immunology Course Clinical Immunology Course
08:50-09:20
Perspectives in immunology Perspectives in immunology Perspectives in immunology Perspectives in immunology Perspectives in immunology
Plenary Lecture
Plenary Lecture
Plenary Lecture
NK Cells
Innate Lymphocytes and
Mucosal Immunity
Leukocyte
Signaling
Genetic and
Epigenetic Control
Cell Trafficking
Costimulatory and
Inhibitory Molecules
Imaging and Cell
Interactions
Lymphocyte
Development
Microbial Triggers
for Inflammation
Pathways in
Inflammatory Diseases
Therapy of
Autoimmune Disease
T and B Cell
Repertoires
Viral Infection
Antigen Processing and
Presentation
Bacterial Infection
Immunodeficiencies
Autoimmune
Mechanisms
Cancer
Immunotherapy
Gene and Cell
Therapy
T and B cell
Subsets
Protozoal Fungal and
Helminth Infection
Parallel symposia
Complement and
Soluble Mediators
Parallel symposia
Innate Immune Sensors
Parallel symposia
Myeloid Cells
Parallel symposia
Parallel symposia
9:00-16:40
Basic Immunology Course
Registration
10:20-12:25
12:30-13:15
Plenary Lecture
Plenary Lecture
09:30-10:15
Immune Memory
Microbiome and
Microbe Adaptation
Immune Surveillance
and Tumor Immunity
Allergy
Vaccination
Tolerance and
Transplantation
Lunch - time Lectures
Lunch - time Lectures
Lunch - time Lectures
Lunch - time Lectures
Lunch - time Lectures
13:20-15:00
Poster Discussion
Poster Discussion
Poster Discussion
Poster Discussion
Poster Discussion
13:30-15:00
Industry Symposia
Industry Symposia
Industry Symposia
Industry Symposia
14:00-15:00
Tutorials
Tutorials
Tutorials
Tutorials
15:10-16:40
Workshops
Workshops
Workshops
Workshops
Workshops
Workshops
Workshops
Workshops
Workshops
Workshops
Plenary Lecture
Plenary Lecture
Plenary Lecture
Plenary Lecture
Plenary Lecture
Late Breaking Session
16:45-18:15
Opening Ceremony
18:30-19:15
Closing
Ceremony
19:20-20:00
19:30-22:00
Welcome Reception
Novartis Award
Ceremony and Reception
Faculty Dinner
Else Kröner Fresenius
Award Lecture
PS - Perspectives in Immunology
PL - Plenary Lectures
S - Symposia
LL - Lunchtime Lectures
W - Workshops
P - Posters
Immunology Courses
Sponsored Sessions
The online abstract book is available at the Congress website www.ici2013.org
Table of Contents
Welcome Messages
page 04
Patronages
page 07
Committees
page 08
Congress Venue
page 10
Congress General Information
page 14
Instruction for Presentation
page 18
Social Program
page 19
IUIS Council and Meetings
page 20
Board Meetings
page 21
Awards
page 22
Travel Grants
page 24
Immunology Courses
page 26
XXIII AINI Congress
page 26
Scientific Program August 22
page 27
Scientific Program August 23
page 28
Scientific Program August 24
page 38
Scientific Program August 25
page 50
Scientific Program August 26
page 60
Scientific Program August 27
page 70
Posters
page 83
Sponsors and Exihibitors
page 270
Speakers index
page 276
Welcome Message
Dear Colleagues and Friends,
Why do we immunologists enjoy attending congresses so
much? I guess the most frequent answers to this question include: you hear the latest news about state-of-the-art science;
you get an excellent overview about what is going on in related
fields; you meet friends, colleagues, young students and experienced researchers alike. For sure, this is all guaranteed at the
International Congress of Immunology (ICI), which takes place
every 3 years under the auspices of the International Union of
Immunological Societies (IUIS). As President of the IUIS, I welcome you to join the 15th ICI to be held in Milan, Italy from
August 22-27, 2013.
For further information about IUIS activities, members of the
Board and the Council see http://www.iuisonline.org/, and for
information about our new official journal Frontiers in Immunology see http://www.frontiersin.org/immunology.
The last ICI, which took place in Kobe, Japan August 2010, was
a marvelous success with more than 6,000 participants. We at the IUIS are proud of the triennial ICI,
which is by far the most important event in the immunology arena, globally. This was proven consistently in the past and is guaranteed at the next ICI in Milan, as assured by the outstanding researchers enlisted in the Congress Advisory Committee, the Scientific Program Committee, and other
Committees.
The 15th ICI promises once again to represent the full complement of one of the most vibrant scientific areas in biomedicine, immunology. It will encompass basic research, translation and clinical
application. It will interest both young students and experienced researchers. It will cover the full
spectrum from academic research to industry.
The Congress, however, will not only serve as platform for communication and exchange of the
most challenging state-of-the-art research among immunologists. It will also serve as impressive platform for making laypersons, the press and politicians aware of the importance of immunologic research for maintenance of well-being, and combat of major diseases, including infectious diseases,
autoimmune diseases or allergic diseases. Last but not least, it will provide a unique platform for
meeting colleagues/friends/post-doc candidates and mentors. In short, the 15th ICI will be wonderful
meeting point for researchers from academia, industry and clinics both from industrialized and developing countries and hence strengthen existing friendships and invite new ones.
The 15th ICI will take place in Milan, Italy and this guarantees another wonderful aspect, namely,
the great opportunity for social activities in a most accessible and welcoming city. Milan boasts a
unique, world famous artistic heritage, of which the best known is Leonardo da Vinci’s Last Supper.
Today Milan is not only the international centre of fashion and design, but also a vibrant city, which
guarantees a lot of fun after a hard working day at the Congress.
The IUIS represents all immunologists worldwide, who are members of the 65 national societies and
4 regional federations of immunology. We are looking forward to meeting you all at the 15th ICI in
Milan.
Stefan H.E. Kaufmann
President, International Union of Immunological Societies (IUIS)
Max Planck Institute for Infection Biology, Berlin
4
Welcome Message
Dear Colleagues and Friends,
The Italian Society of Immunology, Clinical Immunology and Allergology (SIICA) is honoured to host in Milan the 15th International Congress of Immunology (ICI) from August 22 to 27,
2013.
SIICA represents over 1,000 immunologists active in Italy, and
several of its members are recognized as international leaders
in their field, actively contributing to the development of Immunology. Therefore, the scientific organization of the ICI will
count on a dedicated and competent local scientific committee,
in addition to a distinguished international committee.
The meeting will cover all aspects of Immunology, from the
more traditional to the most innovative, with emphasis on
translational aspects and clinical applications. A scientifically inspiring program will be assembled in a range of formats to
cover a wide variety of interests and provide the state of the
art in all different facets of Immunology. An introductory Immunology course just before the ICI, and satellite symposia at several locations in Italy will complement the scientific program. We will also offer a varied social program to provide the opportunity
to meet old friends and make new ones.
Milan has a rich historic heritage, dating back to its times as capital of the Western Roman Empire.
Leonardo da Vinci, the quintessential Renaissance polymath artist and scientist, while in the Milan
area drew his iconic Vitruvian man shown in the 15th ICI logo. Today Milan is a dynamic and trendy
city, a renowned international centre of fashion and design as well as of arts and science. The City
has just opened the largest and most modern congress center in Europe, which will comfortably accommodate the ICI participants.
We are confident that our scientific organization, together with the well-known Italian hospitality
will make the 15th ICI a memorable event.
We look forward to hosting you in Milan in 2013.
Luciano Adorini
President
15th International Congress of Immunology
5
Patronages
Under the High Patronage of the
President of the Italian Republic
With the Patronage of Italian Health Ministry
Under the Patronage of
7
Committees
Committees
Honorary President
Sergio Romagnani, ITA
President
Luciano Adorini, ITA
Secretary General
Massimo Locati, ITA
President SIICA
Vincenzo Barnaba, ITA
Executive Committee
Marco A. Cassatella, ITA
Angela Santoni, ITA
Gianpietro Semenzato, ITA
Silvano Sozzani, ITA
External Relations & Finance Committee
Francesco Annunziato, ITA
Piergiuseppe De Berardinis, ITA
Armando Gabrielli, ITA
Angelo Vacca, ITA
Congress Advisory Committee
Fernando Aiuti, ITA
Jean-Francois Bach, FRA
Ridha Barbouche, TUN
Floriano Bonifazi, ITA
Walter Canonica ITA
Max Cooper, USA
Antonio Coutinho, POR
Günnur Deniz, TUR
Peter C. Doherty, AUS
C. Garrison Fathman, USA
Marc Feldmann, GBR
Alain Fisher, FRA
Catherine Sautes-Fridman, FRA
Michel Goldman, BEL
Jorge Kalil, BRA
Stefan H. E. Kaufmann, DEU
George Kollias, GRC
Carlos Martinez, ESP
Masayuki Miyasaka, JAP
Reinhold E. Schmidt, DEU
Yehuda Shoenfeld, ISR
Elopy Sibanda, ZWE
Giorgio Trinchieri, USA
8
Emil Unanue, USA
Dexian Zheng, CHN
Moncef Zouali, FRA
Scientific Program Committee
Alberto Mantovani, Co-Chairman, ITA
Lorenzo Moretta, Co-Chairman, ITA
Abul K. Abbas, USA
Shizuo Akira, JAP
Jeffrey A. Bluestone, USA
Olivera Finn, USA
Ronald Germain, USA
David Hafler, USA
Leonard Harrison, AUS
Marc Jenkins, USA
Tadamitsu Kishimoto, JAP
Antonio Lanzavecchia, SWI
Foo Y. Liew, GBR
Philippa Marrack, USA
Diane Mathis, USA
Cornelis J.M. Melief, NLD
Luigi Notarangelo, USA
Michael Nussenzweig, USA
Anne O’Garra, GBR
Andreas Radbruch, DEU
Paola Ricciardi-Castagnoli, ITA
Maria-Grazia Roncarolo, ITA
Alexander Rudenski, USA
Ethan Shevach, USA
Alan Sher, USA
Lawrence Steinman, USA
Rolf M. Zinkernagel, SWI (Honorary)
Workshop Committee
Vijay Kuchroo, Co-Chairman, USA
Pier Luigi Meroni, Co-Chairman, ITA
Francesca Aloisi, ITA
Diana Boraschi, ITA
Rachel Caspi, USA
Lucienne Chatenoud, FRA
Edecio Cunha-Neto, BRA
Anna Erdei, HUN
Polly Matzinger, USA
Seppo Meri, FIN
Marianna N. Newkirk, CAN
Fiona Powrie, GBR
Luigina Romani, ITA
Christopher E. Rudd, GBR
Committees
Hannes Stockinger, AUT
Yvette van Kooyk, NLD
Matthias von Herrath, USA
Satellite Meetings Committee
Mohamed R. Daha, Co-Chairman, NLD
Carlo Pucillo, Co-Chairman, ITA
Alberto Amadori, ITA
Luca Battistini, ITA
Francesco Dieli, ITA
Leonardo Fabbri, ITA
Claudio Franceschi, ITA
Gianni Marone, ITA
Vito Pistoia, ITA
Rino Rappuoli, ITA
Maria Rescigno, ITA
Carlo Riccardi, ITA
Mohamed R. Daha, Co-Chairman, NLD
Carlo Pucillo, Co-Chairman, ITA
Advisory Scientific Committee
Sergio Abrignani, ITA
Roberto Accolla, ITA
Carlo Agostini, ITA
Cezmi Akdis, SWI
Sebastian Amigorena, FRA
Bernd Arnold, GER
Jacques Bancherau, USA
Armand Bensussan, FRA
Michael J. Bevan, USA
Sergio Bonini, ITA
Vincenzo Bronte, ITA
Federico Caligaris-Cappio, ITA
Silvana Canevari, ITA
Mario Clerici, ITA
Irun Cohen, ISR
Mario Colombo, ITA
Marco Colonna, USA
Andrea Cossarizza, ITA
Ana Cumano, FRA
Mark M. Davis, USA
Gennaro De Libero, SWI
Michael Dustin, USA
Richard Flavell, USA
Jorge Gavilondo, CUB
Eric Gershwin, USA
Gianpiero Girolomoni, ITA
Gunter Hämmerling, DEU
Adrian C. Hayday, GBR
Richard Hodes, USA
Joachim R. Kalden, DEU
Michael Karin, USA
Klas Kärre, SWE
Mitchell Kronenberg, USA
Lewis Lanier, USA
Sergio Lira, USA
Dan Littman, USA
Yong-Jun Liu, USA
Miguel Lopez-Botet, ESP
Enrico Maggi, ITA
Tak W. Mak, CAN
Bernard Malissen, FRA
Gianvito Martino, ITA
Andrew McMichael, GBR
Fritz Melchers, DEU
Ruslan Medzhitov, USA
Alessandro Moretta, ITA
Tim Mosmann, USA
Kenneth Murphy, USA
Frank O. Nestle, GBR
Markus F. Neurath, DEU
Pamela Ohashi, CAN
Giorgio Parmiani, ITA
Paola Parronchi, ITA
William Paul, USA
Hidde Ploegh, USA
Klaus Rajewsky, USA
Anjana Rao, USA
Jeffrey Ravetch, USA
Caetano Reis e Sousa, GBR
Anna Rubartelli, ITA
Shimon Sakaguchi, JAP
Federica Sallusto, SWI
Ronald Schwartz, USA
Alessandro Sette, USA
Josef Smolen, AUT
Ludwig M. Sollid, NOR
Hergen Spits, NLD
Ralph Steinman, USA
Andreas Strasser, AUS
Nicole Suciu-Foca, USA
Megan Sykes, USA
Franco Tedesco, ITA
Massimo Triggiani, ITA
Jung Tschopp, SWI
Rudolf Valenta, AUS
Andrea Velardi, ITA
Antonella Viola, ITA
Colin Watts, GBR
Hartmut Wekerle, DEU
Katryn Wood, GBR
Wayne Yokoyama, USA
9
Congress Venue Overview
MiCo - Milano Congressi
10
Piazzale Carlo Magno, 1
Via Eginardo - GATE 2
20149 Milan, Italy
POSTER AREA
VB41
D33
C34
VB35
C36
VB37
C39
C40
VB39
D12
D16
C38
E13
E19
E36
E30
C30
C28
D27
VB33
VB31
VB23
VB21
VB19
D17
E20
immunology village
VB29
aisle b
B6
C9
C20
C22
C11
D19
E22
E16
F13
C14
D13
C12
D11
VB17
VB15
VB13
aisle b
B2
C1
aisle c
C16
D15
aisle d
E14
aisle e
E18
aisle f
LUNCH BOX AREA
D21
B8
VB25
C24
D23
E24
F23
C21
VB27
C26
D25
E26
F25
B16
aisle c
C32
D29
aisle d
D31
E28
ice cream
area
E32
aisle e
E34
aisle f
LUNCH BOX AREA
F11
VB11
C10
D9
D10
E11
E12
F9
VB9
C8
D7
E10
F7
VB7
E8
VB5
D2
E1
E6
F5
VB1
bar area
PARETE 3B
PARETE 3A
PARETE 1
INTERNET
POINT
CONTROVENTO
404 PAX
Space 03
872 PAX
Space 01+02
396 PAX
LEVEL 0
Space 04
Floor Plans
11
12
LEVEL +1
LIVELLO +1
Floor Plans
LEVEL +2
LEVEL
Floor Plans
13
Congress General Information
Congress General Information
Congress Secretariat
Triumph C&C
Via Lucilio, 60 - 00136 Roma
www.triumphgroup.it
Contact details:
tel. +39 06 355301
email: [email protected]
Congress Venue
MiCo - Milano Congressi
Piazzale Carlo Magno, 1
Viale Eginardo - GATE 2 - 20149 Milan, Italy
Gate Entrances
Gate 2 - located in Viale Eginardo dedicated entrance for pedestrians during congress days.
Gate 17 - located in Piazzale Carlo Magno dedicated entrance for pedestrians during congress days.
Gate 17 - located in Piazzale Carlo Magno dedicated entrance for cars that wish to park inside the congress venue
during congress days.
Congress Venue Parking
The underground parking entrance is located at Gate 17, Piazzale Carlo Magno.
The cost for a whole day parking ticket is 15 Euros. Payment must be made directly at the exit of the parking lot.
Opening hours in accordance with the congress program and event schedule.
Registration
Registration desk is located on Floor 1 in MiCo Congress Venue.
Registration Desk Hours:
Thursday, August 22
Friday, August 23
Saturday, August 24
Sunday, August 25
Monday, August 26
Tuesday, August 27
from 7.00 to 19.00
from 7.00 to 19.00
from 7.00 to 19.00
from 7.00 to 19.00
from 7.00 to 19.00
from 7.00 to 19.00
Registration Fees:
Delegate registration fee includes:
Access to all sessions and Exhibition Hall
Congress bag and Scientific Program
Opening Ceremony and Reception
Closing Ceremony
Categories
Full
FAIS Member*
Students/Trainee/Resident**
Basic Immunology Course
Clinical Immunology Course
On site
€ 700,00
€ 300,00
€ 300,00
€ 100,00
€ 100,00
* FAIS Member: Federation of African Immunological Societies. Official Letter required.
** Students: Graduate Students, Undergraduate Students, Ph.D. students and Ph.D. candidates.
Official letter and University/Institute ID copy required.
14
Congress General Information
Congress General Information
Name Badges
For security purposes delegates, accompanying persons and exhibitors must wear their name badge at all times in
order to access MiCo congress venue and social activities. Replacement of lost badges may incur a full charge.
Proceedings
Congress Abstracts are available on the official website www.ici2013.org
Certificate of Attendance
A certificate of attendance will be downloaded on ICI2013 website www.ici2013.org from September 10.
Please log back into your registration account using your username and password, in order to receive it by email.
Exhibition
ICI 2013 congress exhibition area is located on Floor 0 in MiCo congress venue.
Exhibition of the most advanced laboratory equipments, supplies, books and journals are on display from Thursday,
August 22 to Tuesday, August 27.
For more information about Exhibition and Exhibitors please refer to the Sponsor section at the end of the book.
Exhibition Hours
Thursday, August 22
Friday, August 23
Saturday, August 24
Sunday, August 25
Monday, August 26
Tuesday, August 27
from 12.30 to 19.00
from 8.00 to 19.00
from 8.00 to 19.00
from 8.00 to 19.00
from 8.00 to 19.00
from 8.00 to 14.30
Internet Access
Free wireless internet service is available following these few steps:
1) Find the Wi-Fi network using your own smart phone or tablet
2) Connect to the network using the following username and password:
USERNAME: 15ICI2013
PASSWORD: 15ICI2013
3) Enjoy surfing the web!
Wi-Fi available in
- Exhibition Hall
- Registration Area
- Balcony
- Corridors
Wi-Fi connection will be disabled in all lecture rooms.
Internet Point
The internet point is located in the exhibition hall next to the poster area (floor 0).
Web App
To get ICI 2013 WEBAPP please follow these guidelines:
1. Open the browser of your mobile device and digit http://ici2013.jokersrl.com/ or scan the QR Code on the
front page of the Scientific Program with your QR Code scanner application.
2. Save the link on your desktop and enjoy the ICI 2013 WEBAPP
During the Congress days, feel free to reach the Speaker Center at level 2, where you will find technicians that
will be able to assist you for any issues regarding the WEBAPP.
15
Congress General Information
Congress General Information
Press Office
The Press Office is located in Suite 4 - Floor 2.
Coffee Shops
Two Coffee shops are located inside the congress venue. Bar Milano, situated in floor 2 in front of the Amber
rooms and Exhibition Bar at floor 0.
Opening hours
August 22
from 8.00 to 17.00
August 23 to 27
from 8.00 to 19.00
Lunch Box
Participants who previously purchased online the Lunch Box service, are kindly asked to collect their box at the
distribution area situated at Level 0 from 12:00 to 13:15, from Friday, August 23 to Tuesday, August 27.
Please provide your lunch box ticket at the lunch box distribution desk. Lunch boxes cannot be purchased onsite.
All participants who have not paid for their lunch boxes online cannot benefit of the service.
Luggage Cloakroom
The cloakroom is located in the registration area on the right side according to the entrance. It is available only as
a luggage deposit and it is free of charge for congress attendees. Opening hours in accordance with the congress
program and event schedule.
Language
The official language of the congress is English. No simultaneous translations are available.
Lost and Found
Information on lost and found is available at the Info Desk at Level 1.
Recording/Photo Policy
It is prohibited to make audio/video recordings or to take photos. An official photographer is present for the entire
event.
Smoking Policy
According to Italian law, smoking is prohibited in all public indoor areas, in this case including privatized areas of
exhibit space.
Italian Telephone Country Code
Country code for Italy: +39
International outgoing code: 00
Emergency Numbers in Italy
Police: 113
Carabinieri: 112
Ambulance: 118
Fire Service: 115
Roadside Assistance: 116
Taxi
Taxi Milan number: 848 814 781
A taxi station is located outside the congress venue in front of Gate 2 in Viale Eginardo and in front of Gate 17
Piazzale Carlo Magno, where taxies are available mostly before and after congress hours.
A taxi booking service is available at the info tourist desk.
16
Congress General Information
Congress General Information
Transportation
MiCo Milano Congressi is easily accessible via pubblic transportation:
Buses & Trams
For “Viale Eginardo / Viale Scarampo” entrance:
Bus No. 78 - Eginardo/Colleoni stop
For “Piazzale Carlo Magno / Via Gattamelata” entrance:
Bus no. 78 - get off at Colleoni/Gattamelata
Tram no. 27 - get off at Piazza 6 Febbraio
Metro
Red Line 1:
For “Viale Eginardo / Viale Scarampo” entrance:
get off at “Amendola” stop - 700 m from the congress venue, or at “Lotto” approx. 800 m.
For “Piazzale Carlo Magno / Via Gattamelata” entrance:
get off at “Cadorna” stop, exit the subway and go to the railroad station above:
take the first train departing and get off at “Domodossola” stop - just 600 m from the congress venue.
Green Line 2:
get off at “Cadorna”.
For “Viale Eginardo / Viale Scarampo” entrance: take Red Line 1 (going to RHO Fiera Milano) and
get off at “Amendola” stop - 700 m from the congress venue, or at “Lotto” approx. 800 m.
For “Piazzale Carlo Magno / Via Gattamelata” entrance: exit the subway and go to the railroad station above:
take the first train departing and get off at “Domodossola” stop - just 600 m from the congress venue.
Yellow Line 3:
get off at “Duomo”, switch to the Red Line 1 (RHO Fiera Milano direction).
For “Viale Eginardo / Viale Scarampo” entrance: get off at “Amendola” stop - 700 m from the congress venue,
or at “Lotto” approx. 800 m.
For “Piazzale Carlo Magno / Via Gattamelata” entrance: get off at “Cadorna” stop, exit the subway and go to the
railroad station above: take the first train departing and get off at “Domodossola” stop - just 600 m from the
congress venue.
Taxi
From/to the airport to the congress venue:
Linate Airport: take bus n. 73 in the National Arrival Exit area to Piazza S. Babila stop.
Take the Metro Red Line 1. Get off at Amendola stop.
Malpensa Airport: The Malpensa Express train service will take you directly from the airport to the center of
Milan in 40 minutes, arriving at the Ferrovie Nord Cadorna Station. Here take the Metro Red Line 1.
Get off at Amendola stop.
Orio al Serio Airport: the bus service will take you directly from the airport to Milan Central Station in 60 mins,
then take the Metro Green Line 2 (Abbiategrasso direction) and get off at Cadorna stop.
Here take the Metro Red Line 1 (Rho Fiera Milano Direction).
Get off at Amendola stop.
17
Instruction for Presentation
Instructions for Presentation
Information for Invited Speakers
Allocated times for presentations in each session are as follows:
Parallel Symposia: 20 mins for each presentation including questions and answers
Perspectives in Immunology: 25 mins for presentation and 5 mins for questions and answers
Plenary Lectures: 40 mins for presentation and 5 mins for questions and answers
Lunchtimes Lectures: 40 mins for presentation and 5 mins for questions and answers
Information for Invited Chairs
Allocated times in each session are as follows:
Workshop Chairs: 15 mins for presentation and /or session presentation
Symposium Chairs: 10 mins for session presentation
Information for Oral Workshop Presentations
10 mins for presentation including questions and answers.
Information and Instructions for Poster Presenters
Poster exhibition area and Poster Information Desk are located at Floor 0.
The week schedule for the poster sessions is as follows:
Friday August 23 to Tuesday August 27:
Mounting
Poster Display
Poster session
Removal
09:00-12:00
12:00-13:20
13:20-15:00
15:00-18:30
Posters can only be mounted on the day on which they have been scheduled for presentation and must
be removed by the end of the same day. All remaining posters will be taken down and discarded.
All poster presenters, on their presentation day, need to report to the Poster Information Desk with their poster
and tape, in order to receive their poster board number. Please ensure your poster is affixed on the correct poster
board.
Please bring your own tape to affix your poster. Limited tape will be available at the Poster information desk.
Poster authors, must stand beside their poster during the poster session for a Question-and-Answer session with
the audience.
The presenters who asked for their posters to be printed by our agent “Poster Session Online” can refer to the
Poster Information Desk at Floor 0, in order to pick it up.
Speaker Center
Location: Floor 2 - Tower Lounge Room
Speaker Center Opening Hours:
Thursday, August 22
Friday, August 23
Saturday, August 24
Sunday, August 25
Monday, August 26
Tuesday, August 27
07:00-19:00
07:00-19:00
07:00-19:00
07:00-19:00
07:00-19:00
07:00-19:00
All Invited Speakers and Oral Presenters are requested to pre-load their presentation 4 hours before
their scheduled presentation. For those who have a session in the morning, it is strongly recommended to load
the presentation the day before.
Every day there will be a poster session for each workshop presentation topic.
18
Social Program
Social Program
Thursday, August 22
OPENING CEREMONY - 16:45 to 22:00
Gold Room - Floor 2
MiCo Milano Congressi Venue - Piazzale Carlo Magno, 1
(Included in the Registration fee for both delegates and accompanying persons)
The inauguration of the 15th INTERNATIONAL CONGRESS OF IMMUNOLOGY will take place at MiCo Milano
Congressi.
The Ceremony will be followed by a welcome reception.
Friday, August 23
NOVARTIS AWARD CEREMONY - 19:30 to 22:00
Gold Room - Floor 2
MiCo Milano Congress Venue - Piazzale Carlo Magno, 1
(Included in the Registration fee for both delegates and accompanying persons)
The Award Ceremony will be followed by a reception.
Sunday, August 25
ELSE KRÖNER-FRESENIUS AWARD LECTURE - 19:30 to 22:00
Gold Room - Floor 2
MiCo Milano Congress Venue - Piazzale Carlo Magno, 1
(Included in the Registration fee for both delegates and accompanying persons)
The Award Ceremony will be followed by a reception.
Monday, August 26
OFFICIAL PARTY - 20:30 to 24:00
Chiostri dell’Umanitaria - Via Daverio, 7
Official Party buffet dinner will be held at the beautiful Chiostri dell’Umanitaria followed by a suggestive
entertainment.
Tickets are on sale at the Registration Desk on August 22 and on August 23, subject to availability.
Cost per person: € 50.00 (VAT included).
Tuesday, August 27
CLOSING CEREMONY - 19:30 to 20:30
Gold Room - Floor 2
MiCo Milano Congress Venue - Piazzale Carlo Magno, 1
(Included in the Registration fee for both delegates and accompanying persons)
Closing Ceremony will take place at the MiCo Congress Venue and it will mark the closing of
the 15th INTERNATIONAL CONGRESS OF IMMUNOLOGY.
TOURS
Different tours are available and purchasable onsite, subject to availability.
The Info Tourist Desk is located at the entrance area on Floor 1 at MiCo congress venue, from August 22
to August 24 from 8:00 to 18:00.
19
IUIS Council and Meetings
IUIS Council and Meetings
IUIS Executive Committee
Stefan Kaufmann IUIS President
Jorge Kalil IUIS Vice-President
Seppo Meri IUIS Secretary General
Nicholas King IUIS Treasurer
Peter Doherty IUIS Past President
IUIS Coucil Members
Olivier Boyer, France
Xuetao Ca, China
Margarida Carneiro, Portugal
Alioune Dieye, Senegal
Ahmed El-Gohary, Egypt
Anna Erdei, Hungary
Jeffrey A. Frelinger, USA
Shigeo Koyasu, Japan
Daniel Lopes, Brazil
Alberto Mantovani, Italy
Michael J.H. Ratcliffe, Canada
Clelia Maria Riera, Argentina
Franca Ronchese, New Zealand
Christopher E. Rudd, United Kingdom
Reinhold E. Schmidt, Germany
René A.W. van Lier, Netherlands
IUIS MEETINGS
Thursday, August 22
09.00-12.30 - 60TH IUIS COUNCIL MEETING - Amber Room 3
Thursday, August 22
13.30-16.30 - IUIS GENERAL ASSEMBLY - Amber Room 4
Friday, August 23
13.30-15.00 - 61TH IUIS COUNCIL MEETING - Amber Room 3
20
Board Meetings and General Assemblies
Board Meetings
Friday, August 23
10.00-14.00 JOHN WILEY & SONS BOARD LUNCH - Suite 2
Friday, August 23
12.30-15.00 AINI BOARD MEETING - Suite 1
Friday, August 23
16.00-20.00 FIMSA BOARD MEETING - Suite 1
Saturday, August 24
8.00-14.00 EFIS - ELSEVIER EDITORIAL BOARD - Suite 1
Sunday, August 25
15.00-18.00 EFIS EEIG MEETING - Suite 1
General Assemblies
Friday, August 23
13.30-15.00 SIICA GENERAL ASSEMBLY Space 4
Friday, August 23
18.30-19.15 AINI GENERAL ASSEMBLY Amber 5+6
21
Awards
Awards
Else Kröner-Fresenius Award Lecture
19.30-22.00 August 25 - GOLD ROOM
The Else Kröner-Fresenius Immunology Award recognizes seminal discoveries in medical immunology and facilitates
future research of the award winner. It is endowed with 4 Mio Euro. An international jury of expert immunologists,
headed by the IUIS president Prof. Stefan Kaufmann, identified Ruslan Medzhitov HHMI and Yale University, as
winner of the award.
EFIS ACTERIA Award Ceremony
13.30-15.00 August 23 - AMBER 1+2
The 2013 ACTERIA Prizes awarded by EFIS in Immunology and Allergology single out four early career scientists
who will make a difference.
The ACTERIA Prizes awarded by EFIS were established to recognize and reward Europe’s young talents in the fields
of immunology and allergology. The two ACTERIA Doctoral Thesis Prizes, for the best dissertations defended in
the last 3 years, and the two ACTERIA Early Career Research Prizes, going to investigators with up to 10 years postdoctoral experience, carry cash awards plus the financing of three-year research projects to be performed in European institutions.
2013 IUIS Day of Immunology Award Ceremony
13.30-15.00 August 25 - BROWN 3
This year for the first time, IUIS and EFIS have worked together to involve all regional and national societies in a
global effort to promote the benefits of immunology research during the International Day of Immunology (DoI)
that took place on April 29, 2013.
Each participating society designed their campaign using any media of their choice, including posters, film, video,
social media, email and regular mail reaching journalists, school teachers, politicians, decision makers and the general public.
Awards are being given based on the campaign’s originality, clarity, and impact at national or regional level. All
national societies and regional federations were eligible to apply for a prize. 22 national societies applied and
named an Ambassador to be the contact person for their campaign.
This year, awards totaling 5000 euros will be given to the top 3 public relations campaign for the Day of Immunology:
1. International Day of Immunology Award, given by IUIS - 2000 euros for the best campaign organized by IUIS
members
2. European Day of Immunology Award, given by EFIS - 2000 Euros for the best campaign in Europe, where the
annual DoI has been celebrated since 2005
3. Award for the Best Newcomer Campaign - 1000 euros given jointly by IUIS and EFIS for the best campaign
organized by a candidate participating in the DoI for the first time
Prizes will be announced during a special awards ceremony at the ICI Milan, 25 August 2013 from 1:30 to
3:00pm in the BROWN room 3. The winners will have the opportunity to present their campaign to the audience.
NOVARTIS Award Ceremony
19.30-22.00 August 23 - GOLD ROOM
The Novartis Prizes for Basic and Clinical Immunology are awarded for outstanding achievements in the understanding of immunological processes in health and disease and major discoveries resulting in novel treatments for
immunological diseases such as autoimmune and inflammatory diseases, transplantation, infectious diseases, immunotherapy of cancer and allergic and dermatological diseases.
The Prizes for Basic and Clinical Immunology are each endowed with SFr 100,000.
22
Awards
Awards Sponsored by Scientific Journals
AWARDS SPONSORED BY SCIENTIFIC JOURNALS
14.00-15.00 August 24 - BROWN 3
THE JOURNAL OF IMMUNOLOGY YOUNG INVESTIGATOR AWARD
4 prizes awarded by AAI representative(s)
NATURE IMMUNOLOGY
$ 500 for the best poster in Innate Immunity
Prize awarded by Dr. Laurie Dempsey (Senior Editor of NI)
NATURE REVIEWS IMMUNOLOGY
$ 500 for the best poster in Adaptive Immunity
Prize awarded by Dr. Lucy Bird (Chief Editor of NRI)
NATURE
1 free subscription for the best poster in Immune receptor and signaling
1 free subscription for the best poster in Immune-mediated disease pathogenesis
Prize awarded by Dr. Ursula Weiss (Senior Editor of Nature)
SCIENCE
1 free subscription for the best poster in Translational immunology and immune intervention
Prize awarded by an ICI representative
IMMUNITY (Cell Press)
1 free subscription for the best poster in Host-pathogen Interactions
Prize awarded by Dr. Peter Lee (Editor of Immunity)
TRENDS IN IMMUNOLOGY (Cell Press)
1 free subscription for the best poster in Innate Immunity
Prize awarded by Dr. Peter Lee (Editor of Immunity)
23
Travel Grants
Travel grants
ICI 2013 Bursaries to Young Immunologists
Travel grants funded by ICI 2013 have been assigned
to worthy young immunologists.
Travel Grants Recipients
1. Aicheler Rebecca (GBR)
2. Bär Eva (SUI)
3. Bar-On Yotam (ISR)
4. Bonaccorsi Irene (ITA)
5. Boström Stéphanie (SWE)
6. Carambia Antonella (GER)
7. Chuang Huai-Chia (TAI)
8. Cook Alistair (AUS)
9. Cuenca Marta (ESP)
10. Dominguez Claudia (USA)
11. Doxaki Christina (GRE)
12. Dudeck Anne (GER)
13. Flaczyk Adam (CAN)
14. Guggino Giuliana (ITA)
15. Hagn Magdalena (AUS)
16. Hanazawa Asami (GER)
17. Hartung Evelyn (GER)
18. He Feng (LUX)
19. Hoeffel Guillaume (SNG)
20. IJspeert Hanna (NED)
21. Jackson Katherine (AUS)
22. Kassianos Andrew (AUS)
23. Kimura Tetsuya (JPN)
24. Laffont Sophie (FRA)
25. Lee Se Na (KOREA)
26. Lo Monaco Elisa (ITA)
27. Lo Presti Elena (ITA)
28. Lund Harald (SWE)
29. Marczy ska Joanna (POL)
30. Marichal Thomas (USA)
31. Messaoudene Meriem (FRA)
32. Moriwaki Kenta (USA)
33. Morvan Maelig (USA)
34. Nadkarni Suchita (GBR)
35. Obata Yuuki (JPN)
36. Ouaguia Laurissa (FRA)
37. Ouchani Farid (FRA)
38. Ramos Ornelia (NED)
39. Rashidi Maryam (AUS)
40. Reboldi Andrea (USA)
41. Schmetterer Klaus (AUT)
42. Schraml Barbara (GBR)
43. Sekai Miho (JPN)
44. Seillet Cyril (AUS)
45. Shimada Kenichi (USA)
46. Spary Lisa (GBR)
47. Szarka Eszter (HUN)
48. Trovato Maria (ITA)
49. Valero-Pacheco Nuriban (MEX)
50. van der Meer Anne (NED)
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IUIS/GATES Foundation travel grants for young
immunologists from developing countries
The IUIS and The Bill and Melissa Gates Foundation
have assigned 36 travel grants to immunologists from
developing countries (non-OECD countries).
Travel Grants Recipients
1. Alonso-Vega Cristina (BOL)
2. Amri Manel (ALG)
3. Anavarathavinayagamoorthy Sivagowry (SRI)
4. Bashir Qudsia (PAK)
5. Bobosha Kidist (ETI)
6. Bogolyubova Apollinariya (RUS)
7. Bortoluci Karina (BRA)
8. Chamakh Rym (TUN)
9. Drif Kamar (MAR)
10. Ganji Rakesh (IND)
11. Hsu Li-Chung (TAI)
12. Kabilova Tatyana (RUS)
13. Kammoun Rebai Wafa (TUN)
14. Kone Younoussou (MLI)
15. Lekomtseva Yevgeniya (UKR)
16. Lenac Roviš Tihana (CRO)
17. Matangkasombut Ponpan (THL)
18. Mduluza Takafira (ZIM)
19. Medina Silva Tiago (BRA)
20. Mendez Huergo Santiago (ARG)
21. Mihret Adane (ETI)
22. Milovanovic Marija (SRB)
23. Mohan Mradul (IND)
24. Muñoz-Wolf Natalia (URU)
25. Ndure Jorjoh (GAM)
26. Nemes Elisa (SUD)
27. Nyakundi Ruth (KEN)
28. Panda Saswati (SIN)
29. Parihar Suraj (SUD)
30. Sabour Alaoui Sanaa (TUN)
31. Tian Jie (CHN)
32. Volkava Marharyta (BLR)
33. Wang Wenyan (CHN)
34. Yacoub-Youssef Houda (MAR)
35. Yessoufou Akadiri (BEN)
36. Zakharyan Roksana (ARM)
Travel Grants
Travel grants
ICI-AAI travel grants for immunologists from
developing countries
The American Association of Immunologists has assigned 20 travel grants to immunologists from developing countries (USAID Developing and Advanced
Developing Countries).
1. Atoum Manar (JOR)
2. Best Ivan (PER)
3. Bhattacharyya Arindam (IND)
4. Blinova Elena (RUS)
5. Capozzo Alejandra (ARG)
6. Clavijo Salomon Maria (BRA)
7. Dergan Dylon Sebastián (ARG)
8. Dias de Melo Guilherme (BRA)
9. Dubey Shweta (IND)
10. Dzoro Sheron (BOT)
11. Gustiananda Marsia (INA)
12. Kanga Uma (IND)
13. Maneerat Yaowapa (TAI)
14. Mihaylova Nikolina (BUL)
15. Mongini Claudia (ARG)
16. Ode Odugbo Moses (NGR)
17. Ramesh Kumar (IND)
18. Retshabile Gaone (BOT)
19. Wada-Kura Aminu (NGR)
20. Yap Fei-Ling (MAS)
Travel grant opportunities provided by National
Societies and Immunological Federations:
•
•
•
•
•
•
•
•
•
•
•
American Association of Immunologists
Austrian Society for Allergology and Immunology
Australasian Society for Immunology
Brasilian Society of Immunology
British Society for Immunology
Canadian Society of Immunology
EFIS European Federation of Immunological Societes
French Society of Immunology
German Society for Immunology
Japanese Society for Immunology
Italian Society of Immunology, Clinical Immunology
and Allergology
• Swiss Society for Allergology and Immunology
• Turkish Society of Immunology
25
Immunology Courses
BASIC IMMUNOLOGY COURSE
COURSE FACULTY:
August 22 - 9.00 - 17.00
BROWN 3
Chairs: Abul K. Abbas, MD (University of California San Francisco, USA)
Andrew H. Lichtman, MD, PhD (Harvard Medical School, Boston, USA)
Abul K. Abbas (USA)
Introduction to the Immune System
Andrew H. Lichtman (USA)
Innate Immunity
Abul K. Abbas (USA)
Antigen Presentation, T Cell Activation and Costimulation
Abul K. Abbas (USA)
T Cell Subsets, Cytokines
Andrew H. Lichtman (USA)
CD8, NK and NK T Cells
Andrew H. Lichtman (USA)
B Cells and Antibodies
Abul K. Abbas (USA)
T Cell Regulation and Tolerance
Abul K. Abbas (USA)
Autoimmunity and Immunological Diseases
CLINICAL IMMUNOLOGY COURSE
August 22 - 8.45 - 17.00
AMBER 5+6
August 23-27 - 8.00 - 8.45
AMBER 1+2
Chair: Reinhold E. Schmidt
26
Friday, August 23
Cezmi A. Akdis (CHE)
Allergies
Saturday, August 24
Bodo Grimbacher (GBR)
Primary immunodeficiencies
Sunday, August 25
Roland Martin (CHE)
Inflammatory diseases of the CNS
Monday, August 26
Herve Fridman (FRA)
Immune surveillance of tumors
Tuesday, August 27
Kathryn Wood (GBR)
Transplant tolerance
SATELLITE MEETING
XXIII AINI CONGRESS
Italian Association of Neuroimmunology
The Neurobiology of the Immune System
August 22, 2013
OPENING CEREMONY
Luciano Adorini, President 15th ICI - Opening speech
Stefan H.E. Kaufmann, IUIS President - Welcome address
Vincenzo Barnaba, President SIICA - Welcome address
Cristina Tajani, Milan City Councillor for Cultural Affairs - Welcome address
Sandro De Palma, piano
Domenico Cimarosa
Cinque Sonate per fortepiano
Domenico Scarlatti
Sonata K. 380 in mi maggiore - Andante comodo
Sonata K.427 in sol maggiore - Più presto possibile
Pastorale (Allegretto) e Capriccio (Vivace)
16.45 - 19.15
GOLD ROOM
Jules Hoffmann (FRA) - Lecture
Innate immunity: from flies to humans
Introduced by Stefan H.E. Kaufmann
Maria Chiara Pavone e Graciela Dorbessan, sopranos
Sandro De Palma, piano
Giacomo Puccini
Mi chiamano Mimì (from La Bohème) Graciela Dorbessan, Soprano
Gioachino Rossini
L’invito (from Soirées musicales) Maria Chiara Pavone, Soprano
Giacomo Puccini
Vissi d’arte (from Tosca) Graciela Dorbessan, Soprano
Gaetano Donizetti
Lu trademiento (Neapolitan song) Maria Chiara Pavone, Soprano
Gaetano Donizetti
I bevitori (Duet for two sopranos and piano) Graciela Dorbessan e Maria Chiara Pavone, Sopranos
Rino Rappuoli (ITA) - Lecture
Designing vaccines for the 21st century society
Introduced by Vincenzo Barnaba
Francesca Dego, violin
Niccolò Paganini
Cantabile per violino e pianoforte (Sandro De Palma, piano)
Capriccio n. 20 (Allegretto)
Capriccio n. 21 (Amoroso, presto)
Capriccio n. 24 (Tema con variazioni, quasi presto)
Welcome Cocktail
5.000 downloads of the musical program (Cimarosa and Scarlatti) will be available on website
www.sandrodepalma.it/intranet
User-ID: 15ICI
Password: muzio2013
27
Chair: Abul Abbas (USA)
Rolf Zinkernagel (CHE)
On immunity or what immunology is all about
PS.02 - PERSPECTIVES IN
IMMUNOLOGY
Chair: Lorenzo Moretta (ITA)
Alain Fischer (FRA)
T cell immunodeficiencies
PL.01 - PLENARY LECTURE
12.30 - 13.15
SPACE 1+2
Chair: Vishna Dixit (USA)
Shizuo Akira (JPN)
Mitochondrial transport by microtubule
acetylation is essential to NLRP3-inflammasome
activation
LL.01 - LUNCHTIME LECTURE
12.30 - 13.15
BROWN 3
Chair: David Hafler (USA)
Abul Abbas (USA)
Immunological tolerance: mechanisms and
therapeutic applications
LL.03 - LUNCHTIME LECTURE
Chair: Matthew Albert (FRA)
Rafi Ahmed (USA)
T cell memory and exhaustion
12.30 - 13.15
SPACE 4
12.30 - 13.15 12.30 - 13.15
BROWN 1+2 GOLD ROOM
12.30 - 13.15
SPACE 3
LL.05 - LUNCHTIME LECTURE
Chair: Fred Alt (USA)
Jean Claude Weill (FRA)
Memory
LL.02 - LUNCHTIME LECTURE
Chair: Eric Vivier (FRA)
Lorenzo Moretta (ITA)
Human NK cells: from basic research to the
therapy of high risk leukemias
LL.04 - LUNCHTIME LECTURE
Chair: Hannes Stockinger (AUT)
Paola Ricciardi Castagnoli (SGP)
NFAT control of innate immunity
LL.06 - LUNCHTIME LECTURE
Chair: Christine Biron (USA)
Hidde Ploegh (USA)
Cloned mice as immunological tools
LL.07 - LUNCHTIME LECTURE
Chair: Gordon Brown (GBR)
Yvette van Kooyk (NLD)
Glycans as dendritic cell targeting strategy for
the induction of immunity and tolerance
18.30 - 19.15
GOLD ROOM
14.00 - 15.00
BROWN 3
12.30 - 13.15
AMBER 1+2
28
8.50 - 9.20
SPACE 1+2
PS.01 - PERSPECTIVES IN
IMMUNOLOGY
9.30 - 10.15
GOLD ROOM
8.50 - 9.20
GOLD ROOM
Main Lectures August 23, 2013
SPECIAL LECTURE
Chair: Marco Colonna (USA)
Ivan Lefkovitz (CHE)
Contribution of Italian scientists to the 30 years
of Basel Institute for Immunology success
PL.02 - PLENARY LECTURE
Chair: Philippa Marrack (USA)
Ruslan M. Medzhitov (USA)
Inflammation and tissue homeostasis
S1 - PATHWAYS IN INFLAMMATORY
DISEASES
S2 - THERAPY OF AUTOIMMUNE AND
AUTOINFLAMMATORY DISEASES
Chairs: Paola Allavena (ITA)
Yoichiro Iwakura (JPN)
Lars Klareskog (SWE)
S1.01 Gene-environment interaction studies as a
basis for unraveling specificity of adaptive
immunity in rheumatoid arthritis
Frank Nestle (GBR)
S1.02 Inflammatory skin disease: from pathways
to targeted therapy
Jeffrey V. Ravetch (USA)
S1.03 A general mechanism for modulating
immunoglobulin effector activity
Suzanne Ostrand-Rosemberg (USA)
S1.04 Tumor-induced myeloid-cell mediated
immune suppression: it is all the RAGE
Mitchell Kronenberg (USA)
S1.05 Regulation of inflammation and mucosal
innate immunity by HVEM, a TNF super family
receptor
Chairs: Moncef Zouali (FRA)
Pierluigi Meroni (ITA)
Peder Olofsson (USA)
S2.01 Neural circuitry regulating immunity:
identification of T-ChAt as a discrete T cell subset
Roland Martin (DEU)
S2.02 Antigen-specific tolerization approaches in
multiple sclerosis - principles and recent data
David Wraith (GBR)
S2.03 Negative feedback regulation of
inflammatory autoimmune responses
Jeffrey A. Bluestone (USA)
S2.04 Treg therapy in autoimmunity: preclinical
and clinical experiences
Josef Smolen (AUT)
S2.05 Treating rheumatoid arthritis: recent
achievements and current prospects
10.20 - 12.25
SPACE 1+2
10.20 - 12.25
GOLD ROOM
Parallel Symposia August 23, 2013
S4 - LEUKOCYTE SIGNALING
Chair:
10.20 - 12.25
BROWN 3
Chairs: Lucienne Chatenoud (FRA)
Foo Y. Liew (GBR)
Gordon Brown (GBR)
S3.01 C-type lectins and anti-fungal immunity
Dan R. Littman (USA)
S3.02 Commensal microbe-dependent induction
of effector T cells in the lamina propria
Gabriel Nunez (USA)
S3.03 Regulation of pathogen colonization by
virulence factors and the microbiota
Francesca Granucci (ITA)
S3.04 Mechanisms and consequences of NFAT
signaling pathway activation downstream of PRRs
in innate immune cells
Giulio Superti Furga (AUT)
S3.05 IFITs, TLRs and innate anti-viral molecular
networks
Peter Murray (USA)
Doreen Cantrell (GBR)
S4.01 T cell metabolism and differentiation
Hua Yu (CHN)
S4.02 STAT3 in tumor immune regulation:
opportunities for clinical translation
Kai W. Wucherpfennig (USA)
S4.03 Control of T cell signaling by membrane
binding of TCR-CD3 ITAMs
Attila Mocsai (HUN)
S4.04 Tyrosine kinases in leukocyte activation and
migration
Oreste Acuto (GBR)
S4.05 Proteomics of T cell signaling: seeing more
and better
S5 - MYELOID CELLS
S6 - LYMPHOCYTE DEVELOPMENT
Chairs: Angel Lopez (AUS)
Angel Corbi (ESP)
John Hamilton (AUT)
S5.01 Colony stimulating factors and macrophage
lineage phenotypes
Miriam Merad (USA)
S5.02 The regulation of the dendritic cell lineage
Hans-Reimer Rodewald (DEU)
S5.03 Fate mapping the origins of fetal and adult
myeloid cells
Marco Cassatella (ITA)
S5.04 Uncovering the regulation of gene
expression in human neutrophils
William Nauseef (USA)
S5.05 Host vs. microbe in the human neutrophil
phagosome
Chairs: Harald von Boehmer (USA)
Stephan Meuer (DEU)
Ellis L. Reinherz (USA)
S6.01 Mechanotransduction processes involved in
T cell development and cognate recognition
Ton Schumacher (NLD)
S6.02 Analysis of antigen-specific T cell responses
at the single cell level
Bruno Kyewski (DEU)
S6.03 Generating self-antigen diversity by genome
scanning in single thymic epithelial cells
Kristen A. Hogquist (USA)
S6.04 The role of self recognition in the
development of various T cell subsets
Gennaro De Libero (SGP)
S6.05 Butyrophilin 3A1 binds phosphorylated
antigens and stimulates human T cells
10.20 - 12.25
SPACE 4
10.20 - 12.25
SPACE 3
10.20 - 12.25
BROWN 1+2
S3 - MICROBIAL TRIGGERS FOR
INFLAMMATION
29
Sponsored Sessions August 23, 2013
MULTICOLOR IMMUNOPHENOTYPING WITH BRILLIANT VIOLET™ FLUOROPHORES
14.00 - 15.00
SPACE 3
with the contribution of Biolegend
Chairs: Hans-Martin Jack (DEU)
Carsten Wiethe (DEU)
Scientific Application Manager, BioLegend
Expanding multicolor options in flow cytometry with novel Brilliant Violet™ fluorophores
Eva Tolosa (DEU)
University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
Improving immune effector cell analysis with Brilliant Violet™ fluorophores
THE NEUROBIOLOGY OF THE IMMUNE SYSTEM
with the contribution of International Society of Neuroimmunology, Target Brain
Chairs: Carlo Avolio (ITA) - Antonio Uccelli (ITA)
15.10 - 18.15
AMBER 5+6
Michal Schwartz (ISR)
Immunity shapes brain function in health, disease and aging: specificity, location and mechanism
Gianvito Martino (ITA)
From brain homeostasis to tissue repair: the immunomodulatory role of neural stem cells
Zaal Kokaia (SWE)
Stroke, stem cells and inflammation
Michal Tomas Olsson (SWE)
Genes and lifestyle factors, and their interactions leading to CNS autoimmune disease: multiple sclerosis
Luca Battistini (ITA)
Immunological hallmarks of multiple sclerosis
Roberto Furlan (ITA)
Microglia microvescicles: a pathogenic and prognostic role is neuroinflammatory and neurodegenerative conditions
NOVARTIS PRIZES FOR IMMUNOLOGY AWARD CEREMONY
19.15 - 20.15
GOLD ROOM
Introduction by Hidde Ploegh (USA)
Address and handover of the prizes by Dhavalkumar Patel, MD, PhD, Head Europe,
Novartis Institutes for Biomedical Research
BASIC IMMUNOLOGY PRIZE
Laudation by Anne O’Garra (GBR)
Lectures by the Prize winners
CLINICAL IMMUNOLOGY PRIZE
Laudation by Diane Mathis (USA)
Lecture by the Prize winner
30
Workshops August 23, 2013
W1.11 - TOLL-LIKE AND PATTERN
RECOGNITION RECEPTORS
W1.11.11 - Bacterial 23S rRNA is recognized by the
endosomal TLR13 unless it is modified to constitute
erythromycin resistance
Anne Krüger, M. Oldenburg, R. Ferstl, A. Kaufmann,
G. Nees, J. Buer, H. Wagner, S. Bauer, H. Hochrein,
C.J. Kirschning
Essen, Germany
IL1.11.01 - Regulation of the innate immune
responses in wild mice
Alexander Poltorak, T. Volkova, I. Kurbatova, V. Ilyuha,
U. Bagina, D. Ram
Boston, United States
W1.11.01 - Emerging roles of an innate immune
regulator TAPE in the endosomal Toll-like receptor
(TLR) and cytosolic RIG-I-like receptor (RLR) pathways
Pin Ling, K. Chen, C. Yang, Y. Lo, C. Huang, T. Tan
Tainan, Taiwan
15.10-18.15
GOLD ROOM
Chairs: John Kagan (USA)
Alexander Poltorak (USA)
W1.11.02 - Smurf2 negatively regulates RIG-I-like
receptor-mediated immune signalling
Yu Pan, J. Zhang
Beijing, China
W1.06 - MACROPHAGES
Chairs: Antonio Sica (ITA)
Subhra Biswas (SGP)
W1.06.01 - Stabilin-1/CLEVER-1 defines an immune
suppressive monocyte population
Senthil Palani, K. Elima, M. Salmi, S. Jalkanen
Turku, Finland
W1.11.05 - CD14 as a key regulator of TLR-mediated
responses of microglia
Hana Janova, T. Regen, D. van Rossum, A. Götz,
W. Brück, U. Hanisch
Goettingen, Germany
W1.06.02 - Mice depleted of LyzM+ macro-phages
develop chronic inflammation and deregulated adaptive immunity
Roham Parsa, H. Lund, X. Zhang, A.O.G. Cacais,
A.M. Georgoudaki, M. Karlsson, R.A. Harris
Stockholm, Sweden
W1.11.06 - Bruton’s tyrosine kinase plays an essential
role in TLR-dependent human DC activation
Vassilios Lougaris, M. Vitali, M. Baronio, G. Tampella,
L. Tassone, A. Soresina, R. Badolato, A. Plebani
Brescia, Italy
15.10-18.15
BROWN 3
15.10-18.15
GOLD ROOM
W1.11.04 - The evolutionary landscape of the NLR
family is reflected in the species-specific response to
infection
Tom P. Monie, L. Hopkins, J. Boyle, W. Amos, C. Bryant
Cambridge, United Kingdom
W1.11.08 - NLRC5-mediated regulation of MHC class
I immune responses
Koichi S. Kobayashi, I. Downs, A. Biswas, T. Meissner,
Y. Liu, K. Lee, A. Li
College Station, USA
W1.11.13 - Redox-based control of synergy and antagonism among TLRs modulates cytokine production
by monocytes
Rosa Lavieri, L. Delfino, P. Piccioli, E. Repaci, P. Castellani,
A. Rubartelli
Genoa, Italy
W1.11.14 - A TNF-CCL20-CCR6 axis drives Nod1-induced B cell recruitment
Jorg H. Fritz
Montreal, Canada
W1.11.03 - PIAS1 negatively modulates virus
triggered type I IFN signalling by blocking the DNA
binding activity of IRF3.
R. Li, Y. Pan, D. Shi, Y. Zhang, Jun Zhang
Beijing, China
W1.11.07 - Lysosomal oligopeptide transporter
SLC15A4 regulates Toll-like receptor 7/9-mediated
autoantibody production
Toshihiko Kobayashi, T. Okamura, N. Toyama-Sorimachi
Tokyo, Japan
W1.11.12 - TLR triggered MAPK signalling is responsible for the regulatory phenotype of macrophages
in response to Schistosoma mansoni cercarial secretions
David E. Sanin, A.P. Mountford
York, United Kingdom
W1.06.03 - Glucocorticoid-induced leucine zipper
(GILZ) inhibits inflammatory activation in
macrophages via reduced MAPK signalling: role in
endotoxin tolerance
Jessica Hoppstädter, T. Stadter, S. Bruscoli, C. Riccardi,
A.K. Kiemer
Saarbruecken, Germany
W1.06.04 - CD300a is a new hypoxia-inducible gene
and a regulator of proinflammatory cytokine
production in human monocytes and macrophages
Federica Raggi, F. Blengio, L. Varesio, M. Bosco
Genoa, Italy
W1.11.09 - Co-ligation of TLR3 and Dectin-1 agonists
potentiates Th1 polarization capability on monocyte
derived Langerhans cells in vitro
Ivan Rajkovic, A. Dragicevic, S. Vasilijic, D. Vucevic,
B. Bozic, D. Mihajlovic, M. Markovic, M. Colic
Belgrade, Serbia
W1.06.05 - Physical interaction between miR-155 and
miR-146a gene loci: Co-regulation during macrophage
activation and induction of endotoxin tolerance
Christina Doxaki, A. Eliopoulos, C. Spilianakis, C. Tsatsanis
Heraklion, Greece
W1.11.10 - TLR-9 dependent dendritic cells activation
by filamentous bacteriophage targeting DEC-205
Rossella Sartorius, L. D’Apice, M. Trovato, G. De Leo,
A. De Matteis, P. Barba, P. De Berardinis
Naples, Italy
W1.06.06 - Single cell dynamics of macrophage
activation and signalling
James S. Bagnall, L. Schmidt, D. Spiller, M.R.H. White,
P. Paszek
Manchester, United Kingdom
31
Workshops August 23, 2013
W1.06.07 - Revisiting the ontogeny of the mononuclear phagocyte system: embryonic and adult
hematopoietic contributions.
G. Hoeffel, Florent Ginhoux
Singapore, Singapore
15.10-18.15
BROWN 3
W1.06.09 - Targeting MIF/CD74 signalling pathway to
dampen acute inflammation in autoimmune diabetes
Hannelie Korf, B. Stijlemans, K. Ciotkowski, J. Laureys,
M. Gilis, C. Gysemans, C. Mathieu
Leuven, Belgium
15.10-16.40
SPACE 1
W1.06.08 - CX3CR1hi Ly6C- monocytes play an
anti-inflammatory role during liver inflammation
Y. Morias, Chloe Abels, D. Laoui, E. Van Overmeire,
E. Schouppe, F. Tacke, P. De Baetselier, A. Beschin
Brussels, Belgium
W5.17.03 - Defective IFN--induced indoleamine 2,3dioxygenase production in patients with macrophage
activation syndrome
Karen Put, F. Fallarino, A. Avau, S. Put, B. Bader-Meunier,
B. Van den Eynde, C. Orabona, P. Quartier, C. Wouters,
P. Matthys
Leuven, Belgium
W1.06.10 - Role of M1 and M2 macrophages in phagocytosis and degradation of amyloid-beta
in Alzheimer's disease transgenic mice
Harald Lund, X. Zhang, R.A. Harris
Stockholm, Sweden
W1.06.12 - IL-4 stimulates macrophage soluble Flt-1
and inhibits murine experimental choroidal neovascularisation
Wei-Kang Wu, L.B. Nicholson, D.O. Bates, A.D. Dick
Bristol, United Kingdom
W5.01 - CYTOKINE REGULATION
IN DISEASE
Chairs: Patricia Bozza (BRA)
Santo Landolfo (ITA)
W1.06.13 - CCR2 expression by macrophages promotes
tumor progression through induction of IL-10
production
Nicoletta Caronni, B. Savino, M. Locati, R. Bonecchi
Milan, Italy
IL5.01.01 - Dengue infection triggers platelet-derived
IL-1: Mechanisms and roles to increased vascular
permeability
E.D. Hottz, J. Lopes, C. Freitas, F.A. Bozza,
Patricia T. Bozza
Rio de Janeiro, Brazil
15.10-16.40
SPACE 1
IL5.17.01 - Epigenetic regulation following AhR
activation leads to suppression of inflammatory and
autoimmune diseases
Prakash Nagarkatti, M. Rouse, N. Singh, M. Nagarkatti
South Carolina, United States
IL5.17.02 - Autoinflammatory diseases
Anna Rubartelli
Genova, Italy
W5.17.01 - The molecular link between PSTPIP1 and
S100A8/S100A9 in autoinflammatory diseases
Selina Fassl, D. Holzinger, J. Austermann, T. Vogl, J. Roth
Muenster, Germany
W5.17.02 - Increased Nlrp3-dependent IL-1 secretion
in patients with familial mediterranean fever: correlation with Mefv genotype
Alessia Omenetti, S. Carta, L. Delfino, A. Martini,
M. Gattorno, A. Rubartelli
Genoa, Italy
32
15.10-16.40
SPACE 2
W1.06.14 - Matrix reprogramming of immune cells
and its disturbance in tumor
Igor Malyshev
Moscow, Russian Federation
Chairs: Prakash Nagarkatti (USA)
Anna Rubartelli (ITA)
W5.17.05 - Identification of commensal flora associated antigen, as a pathogenic factor of autoimmune
pancreatitis
Yoshihiro Abe, N. Yanagisawa, I. Haruta, K. Shiratori,
J. Yagi
Tokyo, Japan
W5.17.06 - Soluble CD91/LRP1 is elevated in the sera
of a subset of children with different inflammatory
diseases
Marianna M. Newkirk, R. Balhous, A. Cimino, Z. Li,
S. Magalhaes, A. Bar-Or, A. Rosenberg
Montreal, Canada
W1.06.11 - IL-17 receptor A regulates renal inflammation and aggravates fibrosis
Shuwang Ge, B. Hertel, H. Haller, S. von Vietinghoff
Hannover, Germany
W5.17 - AUTOINFLAMMATORY
DISEASES
W5.17.04 - Study MHC-II presentation of multiple
sclerosis associated autoantigen using antibodies
with T cell receptor specificity
Efrat Altman, Y. Reiter
Haifa, Israel
IL5.01.02 - Nuclear DNA sensor IFI16 as circulating
protein in autoimmune diseases is a signal of damage
that impairs endothelial cells through high-affinity
membrane binding
Marco De Andrea, M. Bawadekar, F. Gugliesi, V. Dell’Oste,
V. Caneparo, A. Tincani, M. Gariglio, S. Landolfo
Turin, Italy
W5.01.01 - The TNF family member TL1A: a key player
in type 2 immunity in both adaptive and innate
lymphocytes
F. Meylan, E. Hawley, L. Barron, P. Penumetcha, J. Barlow,
A. Richard, T. Wynn, A. Mckenzie, I. Gery,
Richard M. Siegel
Bethesda, USA
W5.01.02 - Oxazolone and ethanol induce
colitis in NOD-scid IL2R null mice engrafted with human peripheral blood mononuclear cells
Roswitha Gropp, T. Nolte, M. Zadeh-Khorasani, F. Rueff,
A. Wollenberg, V. Gülberg, E. Wolf, M. Siebeck
Munich, Germany
W5.01.03 - Chronic infection with Toxoplasma gondii
aggravates experimental sublethal sepsis induced by
CLP and predisposes to septic shock
Maria C. Souza, D.M. Fonseca, A. Kanashiro, L. Benevides,
G. Bonfá, D. Golenbock, R.T. Gazzielli, J.C.F. Alves-Filho,
F.Q. Cunha, J.S. Silva
Ribeirão Preto, Brazil
15.10-16.40
SPACE 2
W5.01.04 - Foxo3 transcription factor controls susceptibility to central nervous system inflammation
Caroline Stienne, N. Carrié, A. Dejean
Toulouse, France
W5.01.05 - Factor Xa and thrombin stimulate an inflammatory and fibrotic response by retinal pigment
epithelial cells: a role in vitreoretinal disorders?
Jeroen Bastiaans, J.C. van Meurs, C. van Holten, M. Smits
- te Nijenhuis, M.J. Kolijn - Couwenberg, N.M.A. Nagtzaam,
M.P. van Hagen, R.W.A.M. Kuijpers, H. Hooijkaas, W.A. Dik
Rotterdam, Netherlands
15.10-16.40
SPACE 3
Workshops August 23, 2013
W2.01 - LEUKOCYTE SIGNALING
Chairs: Emilio Hirsch (ITA)
Vaclav Horejsi (CEC)
W5.01.06 - Aberrant expression of IL-22RA1 on
hematopoietic cells as immunologically signature of
primary Sjogren’s syndrome and Sjogren-associated
non-Hodgkin lymphomas
Giuliana Guggino, F. Ciccia, A. Rizzo, S. Raimondo, A. Giardina, G. Giardina, G. Sireci, R. Alessandro, F. Dieli, G. Triolo
Palermo, Italy
W2.01.01 - The recruitment and activation of phosphatidylinositol 4-phosphate 5-kinases critically regulate CD28-dependent signalling responses
Loretta Tuosto, M. Muscolini, C. Camperio, C. Capuano,
S. Caristi, E. Piccolella, R. Galandrini
Rome, Italy
W2.01.02 - Terminal transport of lytic granules to the
immune synapse is mediated by the kinesin1/Slp3/Rab27a complex
Gaël Menasche, M. Kurowska, N. Goudin, N. Nehme,
M. Court, J. Garin, A. Fischer, G. de Saint Basile
Paris, France
IL2.10.01 - Understanding symptomatic infections in
order to avoid initiation of autoimmunity
Christian Munz
Zurich, Switzerland
15.10-16.40
SPACE 4
W2.10 - AUTOPHAGY AND CELL DEATH
IN THE IMMUNE SYSTEM
Chairs: Christian Münz (CHE)
David Wallach (ISR)
W2.10.01 - Human and mouse mononuclear phagocytes are the only leukocyte subset expressing functional death receptors for Trail
Cristina Belgiovine, M. Liguori, G. Germano, C. Buracchi,
A. Mantovani, P. Allavena
Milan, Italy
W2.01.04 - Molecular tuning of telomerase activity
in highly differentiated human primary CD28−CD27−
T cells
Alessio Lanna, S.M. Henson, D. Escors, A.N. Akbar
London, United Kingdom
W2.01.06 - The impact of arginine methylation on
BCR signalling
Simona Infantino, A. Light, K. O’Donnell, S. Richard,
D. Tarlinton
Melbourne, Australia
W2.10.02 - Target cell death is necessary for cytotoxic
T cell detachment and serial killing
Misty R. Jenkins, J.A. Lopez, J.A. Rudd-Schmidt,
I. Voskoboinik, J.A. Trapani
Melbourne, Australia
W3.03 - THYMIC SELECTION AND
T CELL DEVELOPMENT
W2.10.03 - The switch in T cell survival: Cross-regulation between homeostasis and antigen-induced activation
Susanne Heinzel, P. Koenen, J. Zhang, A. Strasser,
P. Hodgkin
Parkville, Australia
W2.10.05 - p53 contributes to T cell homeostasis
through the induction of pro-apoptotic SAP
Harsha S. Madapura, D. Salamon, K.G. Wiman, S. Lain,
G. Klein, E. Klein, N. Nagy
Stockholm, Sweden
W2.01.03 - The potassium channel KCNK3 determines
calcium signalling pathways in T lymphocytes
Stefan Bittner, H. Wiendl, S.G. Meuth
Münster, Germany
W2.01.05 - The expression and phosphorylation of
HS1 protein are finely tuned in normal and leukemic
B cells
Cristina Scielzo, E. ten Hacken, M.T.S. Bertilaccio, M. Ponzoni, U. Restuccia, A. Bachi, P. Ghia, F. Caligaris-Cappio
Milan, Italy
Chairs: Part Peterson (FIN)
Pawel Kisielow (POL)
15.10-16.40
AMBER 1+2
15.10-16.40
SPACE 3
IL2.10.02 - Regulation of inflammation and cell-death
trough interactions of RHIM-domain protein kinases
with caspase-8
David Wallach, T. Kang, S. Yang, B. Toth, A. Rajput,
J. Kim, A. Kovalenko
Rehovot, Israel
W2.10.04 - IFN- induces an autophagy-mediated antimicrobial response against Mycobacterium leprae
in human monocytes
Bruno J. Silva, P.R. Andrade, T.P. Amadeu, V. Diniz,
S. Côrte-Real, V.C. Valentim, H. Ferreira, J.A.C. Nery,
E.N. Sarno, R.O. Pinheiro
Rio de Janeiro, Brazil
W2.10.06 - Autophagy facilitates TLR4,3-triggered migration and invasion of lung cancer cells by promoting chemokine and IL-6 production through maintaining TRAF6 ubiquitination
Zhenzhen Zhan, X. Zhang, H. Fan, Z. Liu
Shanghai, China
IL3.03.01 - Role of the affinity of TCR-self peptide interaction in commitment to CD4+Foxp3+ and
CD4+Foxp3- T cells and in shaping their TCR repertoires
L. Wojciech, L. Ignatowicz, Pawel Kisielow
Wroclaw, Poland
IL3.03.02 - Anti-cytokine autoantibodies in APECED
correlate with chronic mucocutaneous candidiasis
Pärt Peterson, J. Kärner, K. Kisand
Tartu, Estonia
33
W3.03.01 - Novel role for heparan sulfate in thymic
development of CD8+ T cells
David Anak Simon Davis, C.R. Parish
Canberra, Australia
15.10-16.40
AMBER 1+2
W3.03.02 - B cells engender thymic Tregs
Stacey N. Walters, K.E. Webster, S. Daley, S.T. Grey
Sydney, Australia
W3.03.03 - Involvement of commensal bacteria in
thymic Aire expression
Akihito Nakajima, N. Negishi, H. Tsurui, M. Nanno,
H. Yagita, K. Okumura, S. Habu
Tokyo, Japan
15.10-16.40
AMBER 7+8
Workshops August 23, 2013
W4.13 - IMMUNE REGULATION AT
BARRIER SITES
W3.03.05 - Aire-mediated central tolerance includes
naïve but not post-translational modified selfantigens
Bruno Raposo, P. Merky, R. Holmdahl, J. Bäcklund
Stockholm, Sweden
W4.13.01 - Intestinal epithelium-intrinsic Notch signalling maintains mucosal immune homeostasis by
ensuring epithelial barrier functions
Yuuki Obata, D. Takahashi, Y. Furusawa, S. Hori, H. Ohno,
K. Hase
Tokyo, Japan
Chairs: Piergiuseppe De Berardinis (ITA)
Markus F. Neurath (DEU)
Chairs: Carlo Pucillo (ITA)
Marika Sarfati (CAN)
IL1.02.01 - Mast cells and regulatory cells: a dialogue
that can last a lifetime
Carlo Pucillo
Udine, Italy
W4.13.02 - Oral administration of poly-reactive highaffinity IgA monoclonal antibody against intestinal
microbiota improved inflammatory colitis in mice
Shinsaku Okai, Y. Horii, Y. Shiraki, S. Matsumoto,
T. Naitoh, M. Nanno, K. Yamamoto, K. Kurokawa,
S. Nomura, R. Shinkura
Nagahama, Japan
15.10-16.40
BROWN 1
W1.02 - MAST CELLS
W4.13.03 - Caspase-8 is essential to maintain intestinal barrier function in response to mucosal
pathogens
Claudia Günther, B. Buchen, H. Neumann, M. Neurath,
C. Becker
Erlangen, Germany
IL1.02.02 - Basophils: new key players in lung and intestinal Th2 or Th17-associated chronic inflammatory
disorders
Marika Sarfati
Montreal, Canada
W4.13.04 - CD200 receptor signalling facilitates murine
cytomegalovirus persistence in mucosal tissue
Gabrielle Stack, M. Marsden, M.A. Stacey, E. Jones,
R.J. Snelgrove, S.M. Cuff, A.M. Gallimore, A.N. Barclay,
G.W.G. Wilkinson, I.R. Humphreys
Cardiff, United Kingdom
W1.02.01 - Seven color flow cytometry analyses of
Allergin-1 expression and function on human primary
bronchoalveolar and nasal mast cells
Kei Nagai, S. Tahara-Hanaoka, A. Shibuya
Tsukuba, Japan
W4.13.05 - Endoplasmic reticulum stress aggravates
CVB3-induced myocarditis by promoting NF-B-mediated proinflammatory cytokine production
Yan Yue, S. Xiong, X. Zha, W. Xu
Suzhou, China
W1.02.02 - Soluble CD14 is necessary for LPS-mediated signalling in human intestinal mast cells
Sibylle A. Brenner, S.C. Bischoff, A. Lorentz
Stuttgart, Germany
W4.13.06 - Impaired maintenance of gut homeostasis
in mice lacking GGTase-I in intestinal epithelial cells
Rocío López Posadas, M.O. Bergö, C. Becker, F. Sánchez
de Medina, M.F. Neurath, I. Atreya
Erlangen, Germany
W1.02.03 - Siglec-7 is an Inhbitory receptor on human
mast cells
Sa'ar Mizrahi, B.F. Gibbs, L. Karra, M. Ben-Zimra,
F. Levi-Schaffer
Jerusalem, Israel
W1.02.04 - The S1P/S1PR2 axis controls T-cell infiltration in a mast cell-dependent mouse model of acute
pulmonary inflammation
M.M. Price, Y.T. Falanga, J.J. Ryan, R. Sabbadini, S. Spiegel,
Carole A. Oskeritzian
Columbia, USA
15.10-16.40
BROWN 2
15.10-16.40
AMBER 7+8
W1.02.06 - Mast cells determine the adaptive immune
response in contact hypersensitivity
Anne Dudeck, J. Dudeck, M. Gunzer, A. Roers
Dresden, Germany
W3.03.04 - A key role for PTPN22 in setting the
threshold for natural and inducible regulatory T cell
development
Georgia Fousteri, I. Deberardinis, T. Jofra, S. Stanford,
N. Bottini, M. Battaglia
Milan, Italy
W3.03.06 - Functional study of WW domain-containing oxidoreductase in T cells
Tsung-Hao Chang, L. Hs
Tainan, Taiwan
34
W1.02.05 - IgE-dependent mast cell hyperplasya in
the intestine of cystic fibrosis mouse model needs
KCNN4 channel activity
T.T. Riquelme, L.P. Cid, F.V. Sepúlveda, Carlos A. Flores
Valdivia, Chile
W5.08 - ATHEROSCLEROSIS AND
CARDIOVASCULAR DISEASES
Chairs: Goran Hansson (SWE)
Michelle Letartre (CAN)
IL5.08.01 - T cells regulate lipid metabolism and vascular stability. Role in atherosclerosis
Goran K. Hansson
Stockholm, Sweden
Workshops August 23, 2013
IL5.08.02 - Anti-VEGF therapy normalizes pulmonary
vasculature in Endoglin and Alk1 heterozygous mice
Michelle Letarte, D.S. Ardelean, M. Jerkic, M. Peter
Toronto, Canada
W5.12.02 - Impaired TNF production by dendritic
cells from rheumatoid arthritis patients upon contact
with Porphyromonas gingivalis
Kim C.M. Santegoets, M.H. Wenink, W.B. van den Berg,
T.R.D.J. Radstake
Utrecht, Netherlands
15.10-16.40
BROWN 2
W5.08.02 - Genetically controlled myocardial expression of CXCL9 may be responsible for the selective
migration of Th1 T cells and magnitude of myocarditis
in Chagas disease cardiomyopathy
Edecio Cunha-Neto, L. Nogueira, R.H. Santos, B.M. Ianni,
A. Frade, L. Benvenuti, E. Donadi, B. Saba, A. Fragata, J. Kalil
Sao Paulo, Brazil
W5.08.03 - TGF- signalling in T cells promotes stabilization of atherosclerotic plaques through an IL-17
dependent pathway
Anton Gistera, A.K. Robertson, J. Andersson, D.F.J. Ketelhuth, O. Ovchinnikova, S.K. Nilsson, A.M. Lundberg,
M.O. Li, R.A. Flavell, G.K. Hansson
Stockholm, Sweden
16.45-18.15
SPACE 1
W5.08.01 - Circulating CD40+ and CD80+ B cell subsets
are opposingly associated with risk of stroke
P. Mantani, I. Ljungcrantz, L. Andersson, R. Alm, B. Hedblad, H. Björkbacka, J. Nilsson, Gunilla N. Fredrikson
Malmö, Sweden
W5.08.05 - TIPE2 prevents atherosclerosis by negatively regulating macrophage responses to oxLDL
Y. Lou, Suxia Liu, G. Zhang, Y. Chen, Y. Zhang
Ji'nan, China
Chairs: Gianpietro Semenzato (ITA)
Thomas A. Wynn (USA)
IL5.02.01 - Regulation of wound healing and fibrosis
by macrophages
Thomas A. Wynn, L. Borthwick, L. Barron,
R.W. Thompson, K. Vannella, K. Kindrachuk, K. Hart,
A.W. Cheever, T.R. Ramalingam, P.J. Murray
Bethesda, United States
W5.12 - RHEUMATOID ARTHRITIS
AND OTHER INFLAMMATORY JOINT
DISEASES
16.45-18.15
SPACE 2
16.45-18.15
SPACE 1
Chairs: Olivier Boyer (FRA)
Claudio Lunardi (ITA)
W5.12.01 - DERAA directed T cells: a link between
HLA-II association and rheumatoid arthritis
Jurgen van Heemst, D. Jansen, M. Bax, A. Feitsma,
M. Baarse, A. Moustakas, D. Bontrop-Elferink,
G. Papadopoulos, T. Huizinga, R. Toes
Leiden, Netherlands
W5.12.05 - Endogenous SLPI controls B cell survival
factor expression in TLR3-stimulated rheumatoid synovial fibroblasts
Ngar W. Kam, F. Brentano, D. Kyburz, S. Gay, A. Filer,
C. Buckley, C. Pitzalis, M. Bombardieri
London, United Kingdom
W5.02 - CHRONIC INFLAMMATION
AND FIBROSIS
W5.08.06 - Co-stimulatory signalling through lymphocyte CD40 limits adipose tissue inflammation and
protects from de novo and pre-established metabolic
disease in mice
Dennis Wolf, F. Jehle, N. Bukosza, P. Aichele, N. Varo,
C. Bode, P. Libby, K. Peter, A. Zirlik
Freiburg, Germany
IL5.12.02 - Role of soluble CD30/CD30L and of
CD30/CD30L+ T cells in the modulation of inflammatory response in rheumatoid synovitis
A. Barbieri, E. Tinazzi, A. Rigo, R. Gerli, G. Patuzzo,
R. Beri, A. Puccetti, Claudio Lunardi
Verona, Italy
W5.12.04 - DNAse IgG activity in patients with early
arthritis
Marharyta Volkava, A. Kundzer, I. Generalov
Vitebsk, Belarus
W5.12.06 - In vivo RNAi mediated silencing of HNRNP-A2 decreases chronic inflammation by inhibiting
proliferative and secretory capacity of monocytic cells
Sonja Herman, J. Presumey, M. Koenders,
W. van den Berg, F. Apparailley, G. Steiner
Vienna, Austria
W5.08.04 - A novel role for Rip2 in T cell regulation;
Rip2 deficiency leads to increased Th17 skewing
Kenichi Shimada, S. Chen, T. Crother, W. Zhang, M. Arditi
Los Angeles, USA
IL5.12.01 - Necrotizing autoimmune myopathy: emergence of a new autoimmune disease
Olivier Boyer, L. Drouot, F. Jouen, Y. Allenbach, J. Charuel,
L. Musset, I. Marie, O. Benveniste, &. French Myositis Network
Rouen, France
W5.12.03 - Antibodies from rheumatoid arthritis patients target citrullinated histone 4 contained in neutrophils extracellular traps
F. Pratesi, I. Dioni, M. Alcaro, I. Paolini, F. Panza, I. Puxeddu,
P. Rovero, Paola Migliorini
Pisa, Italy
W5.02.01 - Th-2 cytokine producing Tregs are present
in the skin of patients with systemic sclerosis
Raewyn Broady, J. Huang, K. MacDonald, J. Dunne,
M.K. Levings
Vancouver, Canada
W5.02.02 - IL-33 precursor and bleomycin synergize
in inducing lymphocyte accumulation and fibrosis in
the lungs
Irina G. Luzina, V. Lockatell, P. Kopach, N.W. Todd,
S.P. Atamas
Baltimore, USA
W5.02.03 - A short-term model of COPD identifies a
role for mast cell tryptase
Phil M. Hansbro, E.L. Beckett, R.L. Stevens, A.G. Jarnicki,
R.L. Kim, S. Keely, J.C. Horvat, P.A. Wark, B.G. Oliver,
P.S. Foster
Newcastle, Australia
W5.02.04 - Suppressive role of neuroimmune semaphorin 4A in allergen-induced and VEGF-regulated
lung inflammatory responses
Svetlana P. Chapoval, E. Smith, E. Nkyimbeng-Takwi,
K. Shanks, M.M. Lipsky, L.J. DeTolla, J.A. Elias,
A.D. Keegan
Baltimore, USA
35
16.45-18.15
SPACE 2
Workshops August 23, 2013
W5.02.05 - The condition of host CD4+CD25+ regulatory T cells determines the phenotype of autoimmune-like chronic GVHD
Yuki Akieda, T. Nakamura, E. Wakamatsu, Y. Obata,
S. Ogawa, S. Watanabe, R. Abe
Chiba, Japan
W1.13 - FC AND FC-LIKE RECEPTORS
Chairs: Catherine Sautes Fridman (FRA)
Jeanette H. Leusen (NLD)
IL1.13.01 - Inside-out and outside-in Fc receptors: impact on antibody therapy of cancer
Jeanette H.W. Leusen
Utrecht, Netherlands
W5.02.06 - Endogenous and immune cell derived BDNF
supports regeneration in human skeletal muscle
Emanuela Colombo, F. Bedogni, I. Lorenzetti,
N. Landsberger, S.C. Previtali, C. Farina
Milan, Italy
IL1.13.02 - Fc gamma receptors: a 50 year anniversary
Catherine Sautes Fridman
Paris, France
W1.13.01 - Role of IgG, IgG receptors and neutrophils
in anaphylactic reactions
Friederike Jönsson, D.A. Mancardi, P. Bruhns
Paris, France
W1.01 - GRANULOCYTES
IL1.01.01 - Role of NADPH oxidase-derived reactive oxygen species in human neutrophil IL-1 beta secretion
M.L. Gabelloni, F. Sabbione, C. Jancic, I. Keitelman, L. Iula,
M. Oleastro, J. Geffner, Analia Trevani
Buenos Aires, Argentina
IL1.01.02 - Characterization of cytosolic proliferating
cell nuclear antigen (PCNA) in neutrophils: anti-apoptotic role of the monomer
A. De Chiara, Veronique Witko-Sarsat
Paris, France
16.45-18.15
SPACE 4
Chairs: Veronique Witko-Sarsat (FRA)
Analia Trevani (ARG)
16.45-18.15
SPACE 3
W1.01.01 - Chromatin configurations correlate with
the differential capacity of human neutrophils and
monocytes to express IL-6 in response to LPS
Maili Zimmermann, N. Tamassia, M. Castellucci,
M. Rossato, F. Bazzoni, M.A. Cassatella
Verona, Italy
W1.13.03 - Anti-inflammatory activity of IVIg mediated through the activating FcRIII (CD16) is induced
by ITAMi signalling
Sanae Ben Mkaddem, M. Aloulou, U. Blank,
R.C. Monteiro
Paris, France
W1.13.04 - Antibody opsonised pathogens profoundly alter secondary immune responses through
cross-talk of TLRs and FcRs
Jantine Bakema, K. Tuk, S. van Vliet, S. Bruijns, J. Vos,
S. Letsiou, C. Dijkstra, Y. van Kooyk, A. Brenkman,
M. van Egmond
Amsterdam, Netherlands
W1.01.02 - Influence of CD137L signalling in
myelopoiesis during acute and chronic inflammation
Qianqiao Tang, D. Jiang, J.M.M. Gomez, S. Alonso,
A. Pant, D.M. Kemeny, L. Chen, H. Schwarz
Singapore, Singapore
W1.13.05 - Monocytes rather than NK-cells contribute
to antibody mediated protection from MCMV
infection
Anna Bootz, T. Winkler, M. Mach
Erlangen, Germany
W1.01.03 - Neutrophils have a negative impact on
DC activation and disease progression following
Leishmania major infection
Steffen Schuster, B. Hurrell, D. Ashok, H. Acha-Orbea,
F. Tacchini-Cottier
Epalinges, Switzerland
W1.13.06 - Swiprosin-1/EFhd2 is involved in the initial
reaction of the IgE Fc receptor signal
Yohei Mitsuhashi, M. Hachiya, T. Aradate, Y. Yamanoi,
M. Kanamori, A. Muraguchi, D. Mietenz, T. Katagiri
Toyama, Japan
W1.01.04 - Novel neutrophil-T-Cell interactions:
hormones and the regulation of T-Cell responses
Suchita Nadkarni, F. Marelli-Berg, M. Perretti
London, UK
36
W1.13.02 - Role of the phagocytic synapse in the
recognition of bacteria and the subsequent induction
of Th17-responses
Marrit N. Habets, Z. Yang, H. elMoussaoui, M.I. de Jonge,
D.A. Diavatopoulos
Nijmegen, Netherlands
W1.01.05 - Neutrophil Extracellular Trap formation
in the pathogenesis of Staphylococcus aureus sepsis
Elzbieta Kolaczkowska, P. Kubes
Calgary, Canada
W3.01 - LYMPHOID ORGANOGENESIS
AND LINEAGE COMMITMENT
W1.01.06 - Activated basophils form extracellular
DNA traps able to kill bacteria
Mahbubul Morshed, D. Simon, T. Kaufmann,
R. Hlushchuk, V. Djonov, H. Simon, S. Yousefi
Bern, Switzerland
IL3.01.01 - TNF and both soluble and membranebound lymphotoxins have distinct functions in GALT
organogenesis and in intestinal immunity
A.A. Kruglov, Sergei A. Nedospasov
Berlin, Germany
16.45-18.15
AMBER 1+2
Chairs: Sergei Nedospasov (RUS)
Matthew F. Krummel (USA)
W3.01.01 - The layered immune system: adult
hematopoietic stem cells cannot fully reconstitute all
of the functionally distinct immune cell subsets
Eliver E.B. Ghosn, R. Yamamoto, S. Hamanaka, Y. Yang,
L. Herzenberg, H. Nakauchi, L. Herzenberg
Stanford, USA
Workshops August 23, 2013
W6.03 - PATHOGENESIS AND
IMMUNOINTERVENTION IN DIABETES
W3.01.02 - Deletion of the atypical chemokine receptor CCX-CKR alters thymic stroma, impairs thymocyte
development and promotes autoimmunity
Shaun R. McColl, M. Bunting, N. Seach, M. Hammett,
D.L. Asquith, H. Korner, R.L. Boyd, R.J.B. Nibbs, I. Comerford
Adelaide, Australia
Chairs: Piero Marchetti (ITA)
Leonard Harrison (AUS)
IL6.03.01 - Soluble CD52 released by activated T cells
interacts with Siglec-10 to suppress T cell activation
and prevent autoimmune disease
E. Bandala-Sanchez, Y. Zhang, S. Reinwald, J.A. Dromey,
B. Lee, J. Qian, R.M. Boehmer, Leonard C. Harrison;
Parkville, Australia
16.45-18.15
AMBER 1+2
W3.01.03 - Identification of thymic epithelial stem cells
ensuring lifelong central T cell tolerance
Miho Sekai, Y. Hamazaki, N. Minato
Kyoto, Japan
W3.01.04 - Dissecting the cellular and molecular requirement for Lymphotoxin in orchestrating B cell
accumulation in ectopic follicle like structures in a
rodent model of multiple sclerosis
Natalia Pikor, G. Galicia, D. Ng, J. Gommerman
Toronto, Canada
W6.03.01 - Detection of Chromogranin A-reactive
CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
Niyun Jin, F. Crawford, J. White, M. Philippa, J. Kappler
Denver, USA
W6.03.02 - IL-21 is a critical regulator of chronic/persistent but not acute/accelerated auto-immune and alloimmune responses
Mithun Khattar, P. Schroder, C. Baum, R. Deng, W. Chen,
S. Stepkowski
Toledo, USA
W3.01.05 - Pbx1 restrains myeloid maturation while
preserving lymphoid potential in hematopoietic
progenitors
Francesca Ficara, L. Crisafulli, C. Lin, M. Iwasaki,
L. Zammataro, M.L. Cleary
Milan, Italy
W6.03.03 - Postnatal events in intestinal gene expression and splenic cell composition is altered in
NOD mice
Dina S.M. Damlund, S. Metzdorff, M.B. Kristensen,
A.K. Hansen, K. Buschard, H. Frøkiær
Frederiksberg, Denmark
W1.17 - ALLERGIC MEDIATORS
Chairs: Massimo Triggiani (ITA)
Annika Scheynius (SWE)
W1.17.01 - Novel regulatory control of IgE antibody
responses in vivo
Danyal Butt, T. Chan, R. Brink
Sydney, Australia
16.45-18.15
AMBER 7+8
W1.17.02 - Basophil-derived mouse mast cell protease
11 is involved in the development of IgE-mediated
chronic allergic inflammation
Hayato Deki, Y. Kawano, S. Yoshikawa, M. Iki, M. Egawa,
T. Ohta, H. Karasuyama
Tokyo, Japan
W1.17.03 - Analysis of NK cell subsets in children
with atopic dermatitis
Gunnur Deniz, E. Aktas Cetin, N. Akdeniz, B. Safa,
M. Kosker, Y. Camcioglu, &. Barlan
Istanbul, Turkey
16.45-18.15
BROWN 2
W3.01.06 - Survivin inhibition disturbs Bcl-6 and
Blimp-1 control of lymphocyte differentiation
Maria Bokarewa, S. Andersson, M.N. Svensson,
M. Erlandsson, I. Jonsson, K.M. Andersson
Göteborg, Sweden
W6.03.04 - Antigen-specific protection against highly
aggressive cytotoxic T cells in diabetes by intradermal
injection of heme-oxygenase-1 inducer
Thomas Simon, J. Pogu, S. Pogu, J. Bach, S. Remy,
E. Piaggio, I. Anegon, P. Blancou
Nantes, France
W6.03.05 - Inhibiting Th17 cells and reducing insulitis
in diabetic NOD mice by GW9508, a GPR40 and
GRP120 dual agonist
Zhiguang Guo, A. Ansarullah, Y. Lu, M. Holstein,
B. Deruyter
Sioux Falls, USA
W6.03.06 - New insights into type 1 diabetes development and therapy
Christopher R. Parish, A.F. Ziolkowski, Z. Wu, S.K. Popp,
C. Freeman, C.J. Simeonovic
Canberra, Australia
W1.17.04 - Novel IL-9-producing innate helper cells
promote oral antigen-induced anaphylaxis
Yui-Hsi Wang, C. Chen, J. Lee, B. Liu, F. Finkelman,
S. Hogan
Cincinnati, USA
W1.17.05 - Lack of PTX3 enhanced airway inflammation and hyperresponsiveness in a murine model of
asthma
J. Balhara, L. Shan, Abdelilah Soussi-Gounni
Winnipeg, Canada
W1.17.06 - MicroRNA-155 augments local Th2 response in a mouse model of allergic airway inflammation
Carina Malmhäll, S. Alawieh, Y. Lu, M. Sjöstrand,
A. Bossios, M. Eldh, M. Rådinger
Gothenburg, Sweden
37
Chair: Jeffrey A. Bluestone (USA)
Marc Feldmann (GBR)
Beyond anti-TNF therapy for rheumatoid
arthritis: can we get close to a cure?
PS.04 - PERSPECTIVES IN
IMMUNOLOGY
Chair: Tak W. Mak (CAN)
Philippa Marrack (USA)
T cell receptors, their specificity and role in
selection
PL.03 - PLENARY LECTURE
Chair: Alberto Mantovani (ITA)
Charles A. Dinarello (USA)
Blocking IL-1 to treat inflammatory conditions
LL.10 - LUNCHTIME LECTURE
Chair: Ruslan Medzhitov (USA)
Visnva Dixit (USA)
Recent progress in understanding inflammasome biology
LL.12 - LUNCHTIME LECTURE
Chair: Ellis Reinherz (USA)
Tak W. Mak (CAN)
The four horsemen of anti-apocalypse
12.30 - 13.15
BROWN 3
LL.08 - LUNCHTIME LECTURE
12.30 - 13.15
SPACE 1+2
Chair: Peter C. Doherty (AUS)
Stefan H.E. Kaufmann (DEU)
On immunity in, biomarkers for, and vaccines
against tuberculosis
12.30 - 13.15
SPACE 4
12.30 - 13.15
GOLD ROOM
12.30 - 13.15
BROWN 1+2
12.30 - 13.15
SPACE 3
LL.09 - LUNCHTIME LECTURE
Chair: Angela Santoni (ITA)
Marco Colonna (USA)
Innate lymphoid cells in mucosal immunity
LL.11 - LUNCHTIME LECTURE
Chair: Peter Cresswell (USA)
Tasuku Honjo (JPN)
Molecular mechanism for antibody memory generation
LL.13 - LUNCHTIME LECTURE
with the contribution of
STEMCELL Technologies Inc.
Chair: Cyrus Eduljee (CAN)
Norberto Zwirner (ARG)
Cytokine regulation of natural killer cell effector
functions
LL.14 - LUNCHTIME LECTURE
Chair: Arlene Sharpe (USA)
Bernard Malissen (FRA)
Toward an integrative biology of T cells and dendritic cells
18.30 - 19.15
GOLD ROOM
12.30 - 13.15
AMBER 1+2
38
8.50 - 9.20
SPACE 1+2
PS.03 - PERSPECTIVES IN
IMMUNOLOGY
9.30 - 10.15
GOLD ROOM
8.50 - 9.20
GOLD ROOM
Main Lectures August 24, 2013
PL.04 - PLENARY LECTURE
Chair: Siamon Gordon (GBR)
Alberto Mantovani (ITA)
Interactions between the cellular and the humoral
arm of innate immunity
S7 - CANCER IMMUNOTHERAPY
S8 - INNATE IMMUNE SENSORS
Chairs: Paola Zanovello (ITA)
Gunter Hammerling (DEU)
Olja J. Finn (USA)
S7.01 Cancer immunosurveillance and
immunoprevention
James P. Allison (USA)
S7.02 Mobilizing the immune system to treat
cancer: new insights and opportunities
Cornelis Melief (NLD)
S7.03 TLR-ligand peptide conjugates for superior
therapeutic vaccination against immunogenic
cancers
Andrea Velardi (ITA)
S7.04 Harnessing immunity to leukemia and
infections after haploidentical hematopoietic
transplantation
Drew M. Pardoll (USA)
S7.05 Establishment of immunotherapy as the
fifth pillar of cancer treatment
Chairs: Jerrold P. Weiss (USA)
Mohammed Daha (NLD)
Caetano Reis e Sousa (GBR)
S8.01 Dendritic cells as innate immune sensors
Maya Saleh (CAN)
S8.02 NLRs and inflammasomes in intestinal
homeostasis, cancer and me
Alessandro Moretta (ITA)
S8.03 Human NK cell receptors and pathogen
infection
Peter Parham (USA)
S8.04 Variable natural killer cell receptors and
human evolution
David H. Raulet (USA)
S8.05 NK receptors in immune surveillance and
inflammation
10.20 - 12.25
SPACE 1+2
10.20 - 12.25
GOLD ROOM
Parallel Symposia August 24, 2013
10.20 - 12.25
BROWN 3
Chairs: Peter D. Katsikis (USA)
Lionel B. Ivashkiv (USA)
Gioacchino Natoli (ITA)
S9.01 A genomic framework for macrophage
identity and functional specialization
Alexander Tarakhovsky (USA)
S9.02 The control of the antiviral innate response
by histone mimics
Luke O’Neill (IRL)
S9.03 Metabolism, epigenetics and miRNAs: an
unholy trinity controlling innate immunity
Sergio Abrignani (ITA)
S9.04 Regulation of T lymphocyte effector
functions by non-coding RNAs
Warren J. Leonard (USA)
S9.05 The c family of cytokines: from human
disease to transcriptional regulation
S10 - T AND B CELL REPERTOIRES
Chairs: Mitzi Nagarkatti (USA)
Fritz Melchers (DEU)
Yousuke Takahama (JPN)
S10.01 The thymic microenvironments that shape
T cell repertoire
Michael B. Brenner (USA)
S10.02 iNKT T cells: innate lipid sensing T cells
regulate inflammation
Meinrad Busslinger (AUT)
S10.03 Transcriptional control of early B cell
development
Frederick W. Alt (USA)
S10.04 Long range elements that control mouse
and human IgH V(D)J recombination and
repertoires
Michel C. Nussenzweig (USA)
S10.05 The human antibody response to HIV
S11 - VIRAL INFECTIONS
S12 - IMMUNODEFICIENCIES
Chairs: Mario Clerici (ITA)
Elopy Sibanda (ZBW)
Stipan Jonjic (HRV)
S11.01 Viral regulation of inhibitory and
activating Ly49 receptors
Vincenzo Barnaba (ITA)
S11.02 Viral infections, autoimmunity and
immunoregulation
Christine A. Biron (USA)
S11.03 Cytokine regulation of NK and CD8 T cell
responses to acute viral infections
Giuseppe Pantaleo (CHE)
S11.04 Role of T follicular helper cells in HIV
infection
Bruce D. Walker (USA)
S11.05 T cell control of HIV
Chairs: Ridha Barbouche (TUN)
Anna Villa (ITA)
Steven M. Holland (USA)
S12.01 GATA2 deficiency: one gene, many
manifestations
Jean-Laurent Casanova (USA)
S12.02 Toward a genetic theory of childhood
infectious diseases
Bodo Grimbacher (GBR)
S12.03 How Satan smote job: a novel genetic defect
causing hyper IgE Syndrome
Anne Durandy (FRA)
S12.04 Molecular and functional delineation of
human inherited immunoglobulin class switch
recombination deficiencies
Luigi Notarangelo (USA)
S12.05 Modeling primary Immune deficiencies with
patient-derived induced pluripotent stem cells
10.20 - 12.25
SPACE 4
10.20 - 12.25
SPACE 3
10.20 - 12.25
BROWN 1+2
S9 - GENETIC AND EPIGENETIC
CONTROL
39
Sponsored Sessions August 24, 2013
INTRAVENOUS IMMUNOGLOBULINS IN ANTIBODY DEFICIENCIES AND AUTOIMMUNE
DISEASES
13.30 - 15.00
SPACE 3
with the contribution of Biotest
Chair: Peter Hans-Hartmut (DEU)
Peter Hans-Hartmut (DEU)
Immunoglobulins in primary immunodeficiencies
Krivan Gergely (HUN)
Tolerability and safety of a new 10% intravenous immunoglobulin in patients with primary immunodeficiencies
Stangel Martin (DEU)
Treatment of immune neuropathies with IVIG
INFECTIOUS AGENTS AND AUTOIMMUNITY - PART I
with the contribution of Italian Ministry of Health and Italian Multiple Sclerosis Foundation
13.30 - 15.00
SPACE 4
Project grant n. GR-2010-2313255 R. Mangozzi
Chairs: Francesca Aloisi (ITA) - Christian Münz (CHE)
Francesca Aloisi (ITA)
New emphasis on host-pathogen interactions in autoimmune diseases
Jean-Laurent Casanova (USA)
Human genetics of infectious diseases
Matthias von Herrath (USA)
Viruses and type-1 diabetes
Eicke Latz (DEU)
Role of inflammasomes for chronic inflammatory diseases
40
Workshops August 24, 2013
W6.06 - CANCER IMMUNOTHERAPY
AND ANTITUMOR VACCINES
W6.06.09 - Exploiting the good and blocking the bad:
new strategies to convert the tumor into an in situ
personalized vaccine
C. Vanpouille-Box, K.A. Pilones, M.L. Dustin,
M.H. Barcellos-Hoff, S.C. Formenti, Sandra Demaria
New York, USA
Chairs: Shimon Slavin (ISR)
Giorgio Parmiani (ITA)
IL6.06.01 - Cell therapy of cancer with alloreactive intentionally mismatched IL-2 activated donor lymphocytes targeting anti-cancer killer NK & T cells using
monoclonal and bispecific antibodies
Shimon Slavin, C. Brodie
Tel Aviv, Israel
W6.06.02 - Synergistic 4-1BB and CD28 costimulation
enables CD19-targeted T cells to eliminate aggressive
leukemia, in an IRF7-dependent manner
Maud Condomines, Z. Zhao, C. Kloss, M. Sadelain
New York, USA
15.10-18.15
GOLD ROOM
W6.06.01 - Examination of cancer testis antibodies
and Th1/Th2 cytokines as prognosis markers in
glioma patients treated with Delta-24-RGD oncolytic
adenovirus
Juan Fueyo, F. Lang, C. Gomez-Manzano, A. Yung,
R. Sawaya, C. Conrad
Houston, USA
W6.06.10 - A new class of iNKT cell agonist to harness
tumor immunity
M. Terabe, J.J. O’Konek, S. Kato, S. Takao, L. Izhak, Z. Xia,
P. Illarinov, G. Besra, Jay A. Berzofsky
Bethesda, USA
W6.06.04 - Regeneration of human melanoma antigen-specific T cells from iPSCs derived from mature
CD8+ T cells
Raul Vizcardo, K. Masuda, D. Yamada, T. Ikawa,
K. Shimizu, S. Fujii, H. Koseki, H. Kawamoto
Yokohama, Japan
W6.06.14 - Entire requirement of endogenous type I
interferon for the efficacious cancer treatment with
viral vector-encoded IL-12
Sandra Hervas-Stubbs, J.I. Quetglas, U. Mancheño,
E. Casales, J.I. Riezu-Boj, M.C. Ochoa, M.F. Sanmamed,
N. Thieblemont, C. Smerdou, I. Melero
Pamplona, Spain
W6.06.05 - Isolation of antigen-specific TCR genes
and analysis of disease-associated TCR repertoires by
TCR gene capture
Carsten Linnemann, B. Heemskerk, P. Kvistborg,
R.J.C. Kluin, D.A. Bolotin, R.M. Kerkhoven, M. Nieuwland,
D.M. Chudakov, G.M. Bendle, T.N.M. Schumacher
Amsterdam, Netherlands
W4.01 - IMMUNITY TO VIRUS INFECTION
Chairs: Ahmed El-Gohary (EGY)
Margarida Souto-Carneiro (PRT)
W6.06.06 - Glycoengineered defucosylated anti-CD20
antibodies activate neutrophils-mediated phagocytosis more efficiently than rituximab
Josée Golay, F. Da Roit, L. Bologna, C. Ferrara,
J.H. Leusen, A. Rambaldi, C. Klein, M. Introna
Bergamo, Italy
W6.06.07 - FOXO3 regulates tumor-associated dendritic cell tolerogenicity by binding and sequestering
NF-B
Stephanie K. Watkins, A.A. Hurwitz
Maywood, USA
W6.06.08 - Host immunity contributes to the anti-melanoma activity of BRAF inhibitors
Shin Foong Ngiow, D.A. Knight, M. Li, T. Parmenter,
N.M. Haynes, K. Kinross, H. Yagita, A. Ribas, G.A.
McArthur, M.J. Smyth
Melbourne, Australia
W6.06.12 - Conditioning tumor microenvironments
for effective entry and function of effector T cells
Pawel Kalinski, R. Muthuswamy, N. Obermajer, H.J. Zeh,
A. Zureikat, K. Odunsi, R. Edwards, D. Bartlett
Pittsburgh, USA
W6.06.13 - A bi-institutional pilot study of peptidebased vaccines in combination with poly ICLC in patients with WHO grade 2 low-grade glioma
Hideho Okada, L.H. Butterfield, R.L. Hamilton,
M.O. Lively, M.D. Chan, A.M. Salazar, D.M. Potter,
E.G. Shaw, F.S. Lieberman
Pittsburgh, USA
IL4.01.01 - Genomic polymorphisms in 3-hydroxysterol 24-reductase promoter sequences
N.E. Salem, M. Saito, Y. Kasama, M. Ozawa, T. Kawabata,
S. Harada, H. Suda, K. Asonuma, Ahmed El-Gohary,
K.T. Kohara
Ismailia, Egypt
15.10-18.15
BROWN 3
15.10-18.15
GOLD ROOM
W6.06.03 - Development of a tumor stem cell specific
T-cell engaging antibody for the treatment of glioblastoma multiforme
S. Prasad, S. Gaedicke, M. Hettich, E. Firat, X. Zhu,
K. Klingner, J. Schüler, Gabriele Niedermann
Freiburg, Germany
W6.06.11 - Naive-derived memory stem T cells: a
novel promising platform for cancer immune-gene
therapy
Nicoletta Cieri, B. Camisa, F. Cocchiarella, M. Forcato,
G. Oliveira, E. Provasi, A. Bondanza, F. Mavilio,
A. Mondino, C. Bonini
Milan, Italy
W4.01.01 - Suppressor of cytokine signalling (SOCS)
4 is a critical regulator of the anti-viral immune response
Lukasz Kedzierski, E. Linossi, N. Bird, B. Day, T. Kolesnik,
G. Belz, B. Kile, N. Nicola, K. Kedzierska, S. Nicholson
Parkville, Australia
W4.01.02 - Timing and quality of the type-I interferon
response to viral infection is tuned by stochastic cellular decisions at multiple levels
Ulfert Rand, M. Rinas, J. Schwerk, H. Hauser, D. Spiller,
P. Paszek, M.R.H. White, T. Höfer, M. Köster
Manchester, United Kingdom
41
W4.01.03 - Serological diagnosis of Pepino mosaic
virus with new generated monoclonal antibodies
Amal Souiri, M.M. Ennaji, H. Laatiris, S. Amzazi, M. Zemzami
Casablanca, Morocco
W4.01.04 - An identical microRNA of the human JC
and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination
Yoav Bauman, O. Mandelboim
Jerusalem, Israel
15.10-18.15
BROWN 3
Workshops August 24, 2013
W4.01.05 - CD4+ T cells modulate Epstein-Barr virus
latency types
Noemi Nagy, F. Heuts, D. Salamon, M. Adori, A.E. Rasul,
H.S. Madapura, M. Rottenberg, G. Klein, E. Klein
Stockholm, Sweden
Chairs: Martin Olivier (CAN)
Peter Sebo (CZE)
IL4.04.01 - Lesson from Leishmania Infection to Combat Bacterial-Mediated Inflammatory Response
Martin Olivier
Montréal, Canada
W4.01.08 - Dual deletion of type I and type II interferon-binding proteins in NYVAC-HIV-1 Env-Gag-PolNef poxvirus vaccine vectors markedly improves
vector immunogenicity
Julie Delaloye, A. Filali-Mouhim, M. Cameron, E. Haddad,
M. Esteban, G. Pantaleo, T. Roger, R. Sékaly, T. Calandra
Lausanne, Switzerland
W4.01.11 - Chronic viral infection alters subnuclear
localization of PD-1 and L-selectin loci linked to transcriptional programming in LCMV-specific CD8 T-cells
Catarina Sacristan, B.A. Youngblood, J.X. Xu, P. Lu,
K. McGary, S.L. Hewitt, J.A. Skok, J.M. Boss, R. Ahmed,
M.L. Dustin
New York, USA
W4.01.12 - The anti-apoptotic protein Mcl-1 is essential for the CD8 T cell response upon chronic viral
LCMV infection
Eleonora Ottina, S.P. Preston, A. Strasser, M. Pellegrini,
A. Villunger
Innsbruck, Austria
42
IL4.04.02 - Fooling phagocytes and delivering T cell
vaccines: The ‘yin and yang’ of Bordetella adenylate
cyclase toxin
Peter Sebo
Prague, Czech Republic
W4.04.01 - Orchestration of inflammation and adaptive immunity in Borrelia burgdorferi-induced arthritis by NapA
Gaia Codolo, F. Bossi, P. Durigutto, M.M. D’Elios,
M.A. Cassatella, M. de Bernard
Padua, Italy
15.10-16.40
SPACE 1
15.10-18.15
BROWN 3
W4.01.07 - Evolution of neutralizing antibodies
against HIV-1C gp160 molecular envelope clones
from acute heterosexually acquired HIV-1C infections
in Botswana
Takafira Mduluza, K. Bedi, S. Dzoro, W. Mpoloka,
R. Musonda
Harare, Zimbabwe
W4.01.10 - Molecular characterization of immunoglobulin (Ig) genes reveals that plasmablasts generated
during heterologous secondary dengue infections
and circulating memory B cells after recovery are of
distinct origin
Ramapraba Appanna, M.H. Xu, V. Hadinoto, K. Joensson,
Y.X. Toh, T. Balakrishnan, Y.S. Leo, C. Wang, K. Fink
Singapore, Singapore
W4.01.14 - Spred-2 deficiency exacebates Influenza
A Virus (H1N1)-induced pneumonia
Toshihiro Ito, A. Yoshimura, A. Matsukawa
Okayama, Japan
W4.04 - IMMUNITY TO BACTERIAL INFECTION (EXCLUDING MYCOBACTERIA)
W4.01.06 - HSV-2 regulates inflammatory response in
the vaginal epithelium via the Fas/FasL pathway
Malgorzata Krzyzowska, P. Orlowski, W. Stankiewicz
Warsaw, Poland
W4.01.09 - A novel mechanism of HTLV-1-associated
mylopathy/tropical spastic paraparesis (HAM/TSP)
pathogenesis
Abbas Pishdadian, J. Tavakkol Afshari, M. Foroughi Poor,
A. Zamani
Mashhad, Islamic Republic of Iran
W4.01.13 - Pregnancy-induced deviation of chemokine/cytokine serological levels during influenza
virus AH1N1 infection
Luis A. Flores-Mejía, I. Mancilla-Herrera, E.D. Cerezo,
A. Cérbulo-Vázquez, E. Ferat-Osorio, C.R. López-Macías,
A. Isibasi, L.A. Arriaga-Pizano
México City, Mexico
W4.04.02 - Imaging Bacillus anthracis edema toxin effects on normalized murine dendritic cells and macrophages
Yannick Trescos, D. Fiole, M. Mulier, J.N. Tournier
La Tronche, France
W4.04.03 - Role for coagulation factor XI during
pneumococcal pneumonia independent of factor XII
activation.
Ingrid Stroo, C. van ‘t Veer, J.J.T.H. Roelofs, J.C.M. Meijers,
F.J. Castellino, S. Zeerleder, T. van der Poll
Amsterdam, Netherlands
W4.04.04 - The macrophage serves as a gate-keeper
for the induction of protective host immunity and
bacterial dissemination during Chlamydia infection
Eric Gracey, Y. Baglaenko, A. Lin, A. Akram, R.D. Inman
Toronto, Canada
W4.04.05 - B cells participate on the early stages of
immune response against intracellular bacterial pathogen Francisella tularensis
Zuzana Krocova, K. Kubelkova, L. Plzakova,
L. Zarybnicka, Z. Sinkorova, A. Macela
Hradec Kralove, Czech Republic
W4.04.06 - Immune evasion in Leptospira: the secretion of proteases that cleave complement proteins
Tatiana R. Fraga, D.S. Courrol, M.M. Castiblanco-Valência,
I.Y. Irata, L. Juliano, S.A. Vasconcellos, A.S. Barbosa, L. Isaac
São Paulo, Brazil
Workshops August 24, 2013
W5.09 - NEUROIMMUNOLOGY
W6.16.04 - Fractalkine ligand-receptor axis dictates
prognostic outcome in human colorectal cancer
Marco Erreni, I. Siddiqui, F. Marchesi, S. Pesce,
D. Morone, A. Doni, C. Rumio, L. Laghi, A. Mantovani,
P. Allavena
Milan, Italy
IL5.09.01 - EBV specific CD8+ T cells in Multiple
Sclerosis
Luca Battistini
Rome, Italy
W5.09.01 - Regulatory T cells together with resolving
macrophages orchestrated by Th1 cells are non-redundant pivotal players in CNS repair
Catarina Raposo, M. Schwartz
Rehovot, Israel
15.10-16.40
SPACE 3
Chairs: Luca Battistini (ITA)
Michal Schwartz (ISR)
W6.16.06 - Unique TCR signature of a novel cross-reactive CMV-specific T cell receptor: Potential clinical
implications
Nicole A. Mifsud, T.H.O. Nguyen, L. Rowntree, N. Bird,
D. Pellicci, K. Kedzierska, T. Kotsimbos
Melbourne, Australia
W5.09.03 - IL-33/ST2 axis mediates resistance to EAE by
promoting regulatory B and tolerogenic dendritic cells
Marija Z. Milovanovic, A.N. Arsenijevic, J.Z. Milovanovic,
B. Stojanovic, N.N. Arsenijevic, M.L. Lukic
Kragujevac, Serbia
W3.07 - B CELL DEVELOPMENT AND
PLASMA CELL DIFFERENTIATION
W5.09.04 - N-methyl-D-aspartate receptor (NMDAR)
antibodies in post Herpes Simplex virus encephalitis
neurological relapse
Yael Hacohen, K. Deiva, P. Pettingill, P. Waters, P. Chretien,
E. Menson, e. Lin, M. Tardieu, A. Vincent, M. Lim
Oxford, United Kingdom
W3.07.01 - The Ras/Erk/PI3K pathways during positive selection of primary B cells
Chiara Babolin, L. Sinik-Teodorovic, R. Torres, R. Pelanda
Denver, USA
Chairs: Majorie A. Oettinger (USA)
Hedda Wardemann (DEU)
W5.09.05 - Neuroimmunological changes in the Cstb-/mouse: a model for progressive myoclonus epilepsy
Olesya Okuneva, Z. Li, I. Körber, L. Tian, T. Joensuu,
A. Lehesjoki, O. Kopra
Helsinki, Finland
W3.07.02 - Characterization of umbilical cord blood
CD34+CD43+CD19+CD38lo/int cells suggests a common
progenitor for human B1 and B2 cells
Tam D. Quach, N.E. Holodick, R. Vuyyuru, T. Manser,
T.L. Rothstein
Manhasset, USA
W5.09.06 - Elucidation of pathogenic mechanism of
myasthenia gravis with MuSK antibodies using a
novel murine model
M. Shuuichi, S. Kubo, M. Kishi, T. Konishi, Kazuhiro Shigemoto
Tokyo, Japan
W3.07.03 - A human marginal zone B cell precursor
Marc Descatoire, S. Weller, S. Irtan, J.C. Weill,
C.A. Reynaud
Paris, France
W6.16 - BIOMARKERS AND CLINICAL
PROFILING OF HUMAN IMMUNE
RESPONSES
Chairs: Armando Gabrielli (ITA)
Carlo Selmi (ITA)
W6.16.01 - An autoantibody profile for SLE diagnosis
using the ImmunArray iCHIPTM
Irun R. Cohen, V. Daniel Carmi, L. Belanis-Meirovich,
R. Sorek, O. Cohen-Gindi, N. Dromi, M. Lerner, E. Sahar,
I. Tamir, C. Putterman
Rehovot, Israel
W6.16.02 - Identification of potential biomarkers and
therapeutic targets for multiple sclerosis by M2 proteomics
Itay Raphael, W.E. Haskins, T.G. Forsthuber
San Antonio, USA
15.10-16.40
SPACE 4
15.10-16.40
SPACE 2
W5.09.02 - Triggers of anti-CNS autoimmunity in
mouse model of multiple sclerosis
Pushpalatha Palle, T. Buch
Munich, Germany
15.10-16.40
SPACE 3
W6.16.05 - Tumor-specific adaptive immune responses to primary and metastatic ovarian tumors
C.L. Desmarais, R. Emerson, A. Sherwood, C. Sanders,
M. Tewari, J. Guenthoer, C. Carlson, C. Drescher,
Harlan Robins
Seattle, USA
W3.07.04 - The ELL-associated factor 2 negatively regulates germinal center B cell survival and humoral
immune responses
Yingqian Li, Y. Takahashi, S. Fujii, J. Wang
Yokohama, Japan
W3.07.05 - Epstein-Barr virus-encoded latent membrane protein 2A impairs B cell selection in germinal
centers but not germinal center formation
Takeharu Minamitani, S. Sakakibara, T. Yasui,
H. Kikutani
Suita, Japan
W3.07.06 - IgE-expressing B cells are restrained by an
intrinsic cell fate predisposition
Zhiyong Yang, C.D.C. Allen
San Francisco, USA
W6.16.03 - The alarmins S100A8 and S100A9 as promising targets for non-invasive molecular imaging of
phagocyte activation during inflammation
Tom Völler, M. Eisenblätter, J. Roth, T. Vogl
Münster, Germany
43
Workshops August 24, 2013
W5.22 - PRIMARY IMMUNODEFICIENCIES
W6.01.02 - Effects of w3 fatty acid in experimental
model of mucositis induced by 5-FU
Tatiani U. Maioli, B. Melo, M. Nobre, M.C. Oliveira,
N.C.N. Paiva, V.N. Cardoso, A.C. Faria, A.V.M. Ferreira,
C.M. Carneiro, S.V. Generoso
Belo Horizonte, Brazil
Chairs: Raffaele Badolato (ITA)
Capucine Picard (FRA)
15.10-16.40
AMBER 1+2
W5.22.02 - A new form of global leucopenia associated with mutation in the moesin gene
Chantal Lagresle-Peyrou, F. Ouchani, S. Luce, J. Stephan,
C. Hivroz, G. De Saint Basile, A. Fischer, N. Jabado,
M. Cavazzana-Calvo, I. André-Schmutz
Paris, France
W5.22.03 - Critical role of DOCK8 in dendritic cell trafficking during T cell immune responses
Akira Shiraishi, Y. Tanaka, Y. Fukui
Fukuoka, Japan
15.10-16.40
AMBER 3+4
W5.22.01 - Mucosal immune dysregulation in Omenn
syndrome
Barbara Cassani, V. Maina, V. Marrella, F. Grassi,
J.R. Mora, A. Villa
Milan, Italy
W6.01.04 - Hepatocyte nuclear factor 4 alpha regulates immune cell activation and autoimmunity
Marco Di Dario, E. Colombo, C. Farina
Milan, Italy
W5.22.04 - Investigating T cell subsets in DOCK8 immunodeficiency
Katrina L. Randall, H.D. Law, C.C. Goodnow
Woden, Australia
W6.01.05 - Mast cell protease expression is reduced
in vitro and in vivo in response to cinnamon treatment
Yvonne Hagenlocher, I. Bergheim, S.C. Bischoff,
A. Lorentz
Stuttgart, Germany
W5.22.05 - Resolving the heterogeneity of common
variable immune deficiency by exome sequencing
and deep phenotyping
Matthew C. Cook, J. Al Shekaili, C. Lee, B. Whittle,
D. Andrews, C. Vinuesa, C. Goodnow, D. Fulcher
Canberra, Australia
W6.01.06 - Immunomodulatory effects and antitumor activities of conjugated linolenic acids on the
murine macrophage-like leukemia cells
KN Leung, W. Liu
Hong Kong, China
W5.22.06 - Altered B and T lymphocyte homeostasis
in the bone marrow and the periphery correlates
with clinical findings in common variable immunodeficiency
Vassilios Lougaris, M. Baronio, M. Vitali, S. Masneri,
K. Cattivelli, G. Tampella, D. Moratto, A. Soresina,
R. Badolato, A. Plebani
Brescia, Italy
W3.12 - FOLLICULAR HELPER T CELLS
Chairs: Cecile King (AUS)
Teresa Marafioti (GBR)
IL3.12.01 - Interleukin-21 directs T follicular helper cell
differentiation
A. Vogelzang, H. McGuire, S. Liu, Cecile King
Darlinghurst, Australia
W6.01 - IMMUNOMODULATION BY
NUTRIENTS AND VITAMINS
IL6.01.01 - Stopping T cells in their tracks, vitamin D
suppresses naïve CD8 T cell proliferation
Margherita T. Cantorna, J. Chen, D. Bruce
University Park, United States
IL6.01.02 - Vitamin D regulates complement receptor
immunoglobulin (CRIg) expression in human
macrophages
Antonio Ferrante
Adelaide, Australia
W6.01.01 - Immunomodulatory role of vitamin D in
allergic airway inflammation and airway hyperresponsiveness in bronchial asthma
Devendra K. Agrawal, T. Agrawal, G.K. Gupta
Omaha, USA
15.10-16.40
AMBER 5+6
Chairs: Margherita Cantorna (USA)
Antonio Ferrante (AUS)
15.10-16.40
AMBER 3+4
W6.01.03 - The Agaricus blazed-based mushroom extract, AndosanTM, has immuno- suppressive and antiinflammatory effects when used as supplement to
multiple myeloma patients receiving high-dose chemotherapy and autologous bone marrow transplantation
Geir Hetland, J. Tangen, A. Tierens, G. Kvalheim,
L. Osnes, G. Tjønnfjord
Oslo, Norway
W3.12.01 - Functional overlap of ROQUIN-1 and ROQUIN-2 in the repression of mRNAs controlling Tfh
cell accumulation and systemic inflammation
A. Pratama, R.R. Ramiscal, D.G. Silva, S. Das, Vicki Athanasopoulos, X. Hu, J.J. Hogan, C. Goodnow, M. Cook,
C.G. Vinuesa
Canberra, Australia
W3.12.02 - Identification of human Tfh-specific microRNAs and investigation of their role in Tfh differentiation and function
A. Ripamonti, Elena Provasi, G. Rossetti, S. Curti, V. Ranzani,
V. Parente, F. Facciotti, M. Moro, S. Abrignani, M. Pagani
Milan, Italy
W3.12.03 - Follicular regulatory T cells migrate to germinal centers via NFAT2-mediated signalling
M. Vaeth, G. Mueller, D. Stauss, L. Dietz, S. Klein-Hessling,
E. Serfling, M. Lipp, I. Berberich, Friederike BerberichSiebelt
Wuerzburg, Germany
W3.12.04 - The inhibitory receptor PD-1 regulates IgA
selection and bacterial composition in the gut
Shimpei Kawamoto, T.H. Tran, M. Maruya, K. Suzuki,
Y. Doi, Y. Tsutsui, L.M. Kato, S. Fagarasan
Yokohama, Japan
44
W3.12.05 - Regulation of T helper cell-dependent antibody response in lymphopenic hosts
Silvia Preite, D. Baumjohann, F. Ronchi, F. Sallusto,
A. Lanzavecchia
Bellinzona, Switzerland
W3.12.06 - Fate decision of germinal centre B cells is
based on asymmetric division
Michael Meyer-Hermann, Y. Zhang, G.D. Victora,
K. Toellner
Braunschweig, Germany
W2.04 - MICRORNAS IN IMMUNE
REGULATION
Chairs: Hans-Martin Jack (DEU)
Flavia Bazzoni (ITA)
W2.04.01 - TCD8+ suppressor cells produce antigenspecific exosomes carrying microRNA-150 to inhibit
contact sensitivity response
K. Bryniarski, Katarzyna Nazimek, E. Sikora, M. Ptak,
P.W. Askenase, W. Ptak
Krakow, Poland
15.10-16.40
AMBER 7+8
W2.02.02 - Estradiol promotes functional responses
in inflammatory and steady state dendritic cells
through differential requirement of activation
function-1 of estrogen receptor Sophie Laffont, C. Seillet, N. Rouquié, A. Krust,
P. Chambon, J. Arnal, J. Guéry
Toulouse, France
W2.02.03 - Identification of TREM-1 as a novel target
of nuclear receptor ligands in dendritic cells
Raffaella Fontana, N. Di Meglio, C. Battaglia, M. Mattioli,
M. Cella, C. Doglioni, C. Traversari, M. Colonna, V. Russo
Milan, Italy
15.10-16.40
BROWN 1
15.10-16.40
AMBER 5+6
Workshops August 24, 2013
W2.04.03 - Investigating the impact of individual
miRNAs on Treg conversion
Sebastian C. Warth, A. Hiekel, V. Heissmeyer
Munich, Germany
W4.05 - IMMUNITY TO MYCOBACTERIAL
INFECTION
W2.04.04 - IL-10-induced microRNA-187 negatively
regulates TNF, IL-6 and IL-12p40 production in TLR4stimulated monocytes
Marzia Rossato, G. Curtale, N. Tamassia, M. Castellucci,
L. Mori, S. Gasperini, B. Mariotti, M.A. Cassatella,
M. Locati, F. Bazzoni
Verona, Italy
Chairs: Anca Dorhoi (DEU)
Harriet Mayanja-Kizza (UGA)
IL4.05.01 - Ex vivo chemokines and cytokines measrurements as biological markers in the immuno-diagnosis of active pulmonary tuberculosis
Harriet Mayanja-Kizza, A. Namuganga, M. Nsereko,
G. Muzanye, J. Baseke, P. Peters
Kampala, Uganda, Uganda
15.10-16.40
BROWN 1
Chairs: Cosima Baldari (ITA)
Antonio Moschetta (ITA)
IL2.02.01 - Modulation of TCR signaling and T cell
activation by glucocorticoids: facts and hypotheses
Cosima T. Baldari
Siena, Italy
W2.02.01 - Antagonistic actions of Rcor proteins refine LSD1 activity and restrain cellular differentiation
A.H. Chowdhury, G. Upadhyay, D. Kim, Shireen Saleque
New York, USA
16.45-18.15
SPACE 1
W2.04.05 - MicroRNA-146a promotes IVIg-mediated
inhibition of NFB activation in LPS-treated human
monocytes
Lionel Loubaki, D. Chabot, I. Paré, R. Bazin
Québec, Canada
W2.02 - NUCLEAR RECEPTORS
W2.02.05 - Th17-mediated B cell activation contributes to splenomegaly in PPAR hypomorphic mice
Ya-Hui Liu, Y. Tsai, P. Tsai
Tainan, Taiwan
W2.02.06 - Expression levels of mRNA for GR, GR,
11HSD1 and GR/ ratio in peripheral blood mononuclear cells from patients with pulmonary tuberculosis, throughout the 6-month course of etiological
treatment and 3 month following its completion
L.D. D’Attilio, A. Díaz, B. Bongiovanni, N.S. Santucci,
G. Dídoli, W. Gardeñez, A. Del Rey, H. Besedovsky,
O.A. Bottasso, María L. Bay
Rosario, Argentina
W2.04.02 - The role of microRNA-142-5P in experimental colitis
Anje A. te Velde, M.M.W. Slaman, F.H. van Dooren,
C. Kunne, S.L. Meijer, K. Fluiter, E.W. Vogels, P.D. Moerland
Amsterdam, Netherlands
W2.04.06 - MicroRNA regulation of bacterial infection
in the lung
Hock L. Tay, G.E. Kaiko, P.M. Hansbro, P.S. Foster
Newcastle, Australia
W2.02.04 - Retinoic acid-rich microenvironment provides clonal survival cues for tumor and bacteria-specific CD8+ T cells
Yanxia Guo, K. Pino-Lagos, R. Noelle
Lebanon, USA
W4.05.01 - Antigen transfer drives CD4 T cell activation in tuberculosis
Smita Srivastava, J. Ernst
New York, USA
W4.05.02 - Accumulation of Gr-1dim myeloid-derived suppressor cells during experimental TB infection in mice
Evgeny N. Tsiganov, A.M. Razinkova, I.V. Lyadova
Moscow, Russian Federation
W4.05.03 - Annexin1 plays a critical role in dendritic
cells cross-presentation and protection against Mycobacterium tuberculosis
Maziar Divangahi, F. Tzelepis, J. Daoud, J. Jaworska,
T. Nishimura, M. Verway, K. Hassani-Ardakani,
H.G. Remold, H. Vali, M. Tabrizian
Montreal, Canada
W4.05.04 - Analysis of the global CD8 T cell response
during Mycobacterium tuberculosis infection
Diana Di Liberto, M. La Manna, N. Caccamo, G. Pietra,
C. Mingari, L.C. Sullivan, A.G. Brooks, F. Dieli
Palermo, Italy
45
16.45-18.15
SPACE 1
Workshops August 24, 2013
W1.15 - INFLAMMASOME
W4.05.05 - Cytokine polymorphisms, their influence
and levels in Brazilian patients with pulmonary tuberculosis during anti-tuberculosis treatment
Eliana Peresi, L.R.C. Oliveira, W.L. da Silva, E.A.P.N. da
Costa, J.P. Araujo Junior, J.A. Ayres, M.R.P. Fortes,
E.A. Graviss, A.C. Pereira, S.A. Calvi
Botucatu, Brazil
Chairs: Eicke Latz (DEU)
Olaf Gross (CHE)
IL.15.01 - Role of inflammasomes for chronic inflammatory diseases
Eicke Latz
Bonn, Germany
W4.05.06 - Mycobacterium tuberculosis-specific lung
innate and adaptive immunity in close contacts of TB
index cases
Jonathan G. Peter, A. Binder, M. Davids, R. Meldau,
R. van Zyl-Smit, K. Dheda
Cape Town, South Africa
IL.15.02 - Inflammasome activators induce the secretion of IL-1 via two distinct pathways displaying differential requirement for a protease activityindependent function of caspase-1
Olaf Groß
München, Germany
W1.15.01 - Cytosolic cathepsin inhibitor Stefin B (Cystatin B) regulates NLRP3 inflammasome activation
Katarina Maher, B. Jeric, B. Turk, N. Kopitar Jerala
Ljubljana, Slovenia
W5.10 - MULTIPLE SCLEROSIS
IL5.10.01 - CNS tissue damage by T cells
Roland Liblau
Toulouse, France
IL5.10.02 - Immunological knowledge integration in
MS
Marco Salvetti
Rome, Italy
16.45-18.15
SPACE 3
Chairs: Roland Liblau (FRA)
Marco Salvetti (ITA)
16.45-18.15
SPACE 2
W5.10.01 - Identification, isolation and characterization of brain-infiltrating, in situ clonally expanded T
cell clones in multiple sclerosis
Raquel Planas, N. Vilarrasa, B. Reinhart, S. HoffmeisterUllerich, I. Metz, W. Brück, B. Fehse, C. Pinilla, R. Martin,
M. Sospedra
Zürich, Switzerland
W1.15.05 - TLRS-induced PAI-2 expression suppresses
NLRP3-dependent caspase-1 activation and IL-1B processing
L.C. Hsu, Shih-Yi Chuang, C. Yang, C. Lee, C. Chou
Taipei, Taiwan
W5.10.03 - Cell-intrinsic estrogen receptor activation
in CD4+ T cells control Th1/Th17 differentiation in
trans and protect from CNS autoimmunity
Sophie Laffont, L. Garnier, N. Rouquié, J. Guéry
Toulouse, France
W1.15.06 - NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production
Karina R. Bortoluci, V.M. Gonçalves, K.C. Matteucci,
B.H. Miollo, C.L. Buzzo, D. Ferrante, J.M. Alvarez,
M.M. Rodrigues
Sao Paulo, Brazil
W5.10.04 - A role for TNF signalling in cortical grey
matter pathology in multiple sclerosis
Roberta Magliozzi, P. Durrenberger, O. Howell,
F. Roncaroli, E. Aricò, F. Aloisi, R. Reynolds
London, United Kingdom
46
W3.11 - GAMMA-DELTA T CELLS
Chairs: Dieter Kabelitz (DEU)
Adrian Hayday (GBR)
16.45-18.15
SPACE 4
W5.10.06 - Confirmation of human endogenous
retrovirus HERV-Fc1 role in multiple sclerosis risk
Belen de la Hera, J. Varadé, I. Alloza, A. Alcina, R. Arroyo,
R. Álvarez-Lafuente, K. Vandenbroeck, F. Matesanz,
E. Urcelay
Madrid, Spain
W1.15.03 - The NLRP3 inflammasome links complement-mediated inflammation and IL-1 release
Federica Laudisi, R. Spreafico, M. Evrard, B. Mandriani,
S. Baalasubramanian, A. Mortellaro
Singapore, Singapore
W1.15.04 - Fas-mediated inflammatory response in
Listeria monocytogenes infection
Ryosuke Uchiyama, H. Tsutsui
Nishinomiya, Japan
W5.10.02 - T cells specific for both a myelin and a
neuronal antigen are frequent in C57BL6 mice and
contribute to CNS inflammation during EAE
Liliana E. Lucca, A. Ramadan, S. Desbois-Beaumel,
P. Rufas, J. Guery, T.L. Geiger, R.S. Liblau, L.T. Mars
Toulouse, France
W5.10.05 - Characterization of the impact of CD25
blockade on the NK and T cell populations of relapsing-remitting multiple sclerosis patients
David J. Huss, D.S. Mehta, L. Amaravadi, J.S. Elkins,
J.D. Fontenot
Cambridge, USA
W1.15.02 - The inflammasome adaptor ASC forms a
prion-like danger signal that perpetuates inflammation
Bernardo S. Franklin, D. De Nardo, G. Horvarth,
S. Zimmer, S. Hornemann, A. Aguzzi, E. Latz
Bonn, Germany
IL3.11.01 - Regulatory interactions between granulocytes and gamma/delta T cells in response to aminobisphosphonates
Dieter Kabelitz, V. Chandrasekaran, T.K. Lindhorst, S. Kalyan
Kiel, Germany
W3.11.01 - Heterogeneity and prognostic influence
of tumor- infiltrating T lymphocytes in colon cancer patients
Elena Lo Presti, S. Meraviglia, G. Cicero, V. Orlando,
S. Buccheri, M.P. La Manna, D. Di Liberto, S. Cutrera,
N.Caccamo, F. Dieli
Palermo, Italy
16.45-18.15
SPACE 4
W3.11.02 - Key role of free heavy chain of HLA-I molecules in HCMV and tumor stress sensing by TCR
Romain Marlin, S. Netzer, V. Pitard, S. Daburon, C. Harly,
T. Bachelet, J. Moreau, J. Taupin, J. Déchanet-Merville
Bordeaux, France
W3.11.03 - Implication of T cells in the immune response against murine CMV
Camille Khairallah, S. Netzer, M. Juzan, A. Villacreces, V.
Praloran, J. Moreau, J. Dechanet-Merville, M. Capone
Bordeaux, France
16.45-18.15
AMBER 1+2
Workshops August 24, 2013
W3.11.04 - HDAC7 plays a significant role in T cell
development and function
Matthew G. MacKenzie, C. Gawden-Bone, S. Matthews
Dundee, United Kingdom
Chairs: Emilio Jirillo (ITA)
Giuseppe Matarese (ITA)
IL6.02.01 - Polyphenols from red grape and modulation of the immune Response
Emilio Jirillo, Y. Kumazawa, V. Pugliese, S. Fontana, G.
Marzulli, T. Magrone
Bari, Italy
W3.11.06 - Major contribution of T cells to IL-17A
production and ovarian cancer growth in vivo
Margarida Rei, T. Lança, R. Thompson, F. Balkwill, H.
Kulbe, B. Silva-Santos, D. Pennington
Lisbon, Portugal
IL6.02.02 - Intracellular metabolic pathways control
immune tolerance
Giuseppe Matarese
Baronissi, Salerno, Italy
W6.02.01 - Insulin impairs regulatory T cell function:
implications for obesity
Jonathan M. Han, S.J. Patterson, J.A. Ehses, M.K. Levings
Vancouver, Canada
W4.02 - LIVER VIRAL INFECTIONS
Chairs: Mario Mondelli (ITA)
Frank Chisari (USA)
16.45-18.15
AMBER 1+2
W4.02.02 - Reactive oxygen species delay control of
lymphocytic choriomeningitis virus
Haifeng C. Xu, D.R. McIlwain, A.A. Pandyra, M. Recher,
D. Brenner, D. Häussinger, P.S. Ohashi, T.W. Mak, K.S.
Lang, P.A. Lang
Dusseldorf, Germany
W4.02.03 - Cellular inhibitors of apoptosis (IAPs) play
a critical role in the host response to hepatitis B virus
and their repression promotes viral clearance
Gregor Ebert, S. Preston, C. Allison, J. Toe, J. Cooney, H.
Scott, M. Pellegrini
Melbourne, Australia
16.45-18.15
AMBER 3+4
IL4.02.01 - Innate Sensing A Virus Designed Not To Be
Seen
Francis V. Chisari
La Jolla, United States
W4.02.01 - Dynamic changes in the liver upon persistent viral infection
A. Bhattacharya, J. Colinge, K. Bennett, Andreas Bergthaler
Vienna, Austria
W4.02.06 - Breaking T cell tolerance to viral antigens
in a model of chronic HBV infection
Marianna Di Scala, I. Gil-Fariña, L. Vanrell, M. Scarpino,
C. Olagüe, A. Vales, M. Galarraga, L. Guembe, J. Prieto, G.
González-Aseguinolaza
Pamplona, Spain
W6.02 - METABOLISM AND IMMUNITY
INTERFACES
W3.11.05 - A network of High Mobility Group box
transcription factors programs innate IL-17 production
Nidhi Malhotra, K. Narayan, O. Cho, K. Sylvia, H. Melichar, M. Rashighi, V. Lefebvre, J.E. Harris, L.J. Berg, J. Kang
Worcester, USA
IL4.02.02 - NK cells and HCV: a complex and controversial relationship
Mario U. Mondelli, S. Varchetta, B. Oliviero, S. Mantovani, D. Mele
Pavia, Italy
W4.02.05 - Tim-3/galecin-9 pathway modulates the
cross talk between NK cells and CD8+ T cells in chronic
hepatitis B
D. Zhao, L. Gao, X. Liang, Chunhong Ma
Jinan, China
W6.02.02 - Investigating the anti-inflammatory effects of high density lipoprotein in macrophages
Dominic De Nardo, L. Labzin, H. Kono, R. Seki, S. Schmidt,
M. Kneilling, D. Lütjohann, S. Wright, J. Schultze, E. Latz
Bonn, Germany
W6.02.03 - Obesity-associated autoantibody production requires AIM to retain IgM immune complex on
follicular dendritic cells
Satoko Arai, S. Honda, A. Shibuya, Q. Li, T. Miyazaki
Tokyo, Japan
W6.02.04 - Novel factors regulating chemerin synthesis and function in fat tissue
Mateusz Kwitniewski, M. Bana , N. Harasymowicz, J.
Marczy ska, K. Kwiecie , B.A. Zabel, J. Cichy
Krakow, Poland
W6.02.05 - Amino acid sensing by mTORC1 is the vital
prerequisite for alternative activation of macrophages
Tetsuya Kimura, S. Nada, M. Okada, A. Kumanogoh
Suita, Japan
W6.02.06 - Gene profile of myeloid-derived suppressive cells from the bone marrow of lysosomal acid lipase knock-out mice
Cong Yan, X. Ding, N. Dasgupta, L. Wu, H. Du
Indianapolis, USA
W4.02.04 - Imaging the innate immune response to
viral infection: neutrophils, platelets, and NETs
Craig N. Jenne, C.H.Y. Wong, F.J. Zemp, B. McDonald,
M.M. Rahman, P.A. Forsyth, G. McFadden, P. Kubes
Calgary, Canada
47
Workshops August 24, 2013
W3.14 - B CELLS IN AUTOIMMUNITY
AND REGULATORY B CELLS
W2.03.01 - Regulatory non-coding RNAs as modulators of human lymphocytes differentiation
V. Ranzani, A. Arrigoni, R.J. Bonnal, Grazisa Rossetti,
S. Curti, E. Sugliano, E. Provasi, V. Parente, S. Abrignani,
M. Pagani
Milan, Italy
Chairs: Claudia Mauri (GBR)
Fabienne Mackay (AUS)
IL3.14.01 - TACI regulates T-independent marginal
zone B cell responses through innate activation-induced cell death
Fabienne Mackay, W. Figgett, A. Strasser, P. Hertzog,
K. Fairfax, V. Fabien, D. Saulep-Easton, M. Le Page,
L. O'Reilly, S. Gerondakis
Melbourne, Australia
16.45-18.15
AMBER 5+6
W3.14.01 - Dual-reactive and autoreactive B cell selection and function in autoimmunity.
Roberta Pelanda, E. Fournier, L. Teodorovic, C. Babolin,
S. Rowland, R.M. Torres.
Denver, USA
16.45-18.15
AMBER 7+8
IL3.14.02 - Regulatory B and iNKT cells interaction:
novel mechanism of Suppression
Claudia Mauri, A. Bosma, A. Abdel-Gadir, E. Jury
London, United Kingdom
W2.03.02 - Bromodomain inhibition enhances tolerogenic properties in dendritic cells
Ronald Schilderink, L.E. Nijhuis, F.W. Hilbers, R.K. Prinjha,
W.J. de Jonge
Amsterdam, Netherlands
W3.14.02 - The atypical IB protein IBNS is important for TLR-induced IL-10 production in B cells
M. Miura, M. Noguchi, Maki Touma
Niigata, Japan
W2.03.06 - Unique epigenetic signatures are associated with the induction, silencing and re-expression
of CD8 during T cell development and activation
Kim L. Charlton, E.B. Day, B.E. Russ, S.H. Apte, S.J. Turner,
A. Kelso
Parkville, Australia
W3.14.04 - Analysis of a wild mouse promoter variant reveals a novel role for FcRIIb in the control of
the germinal center and autoimmunity
Marion Espeli, M. Clatworthy, S. Boekers, K. Lawlor,
A. Cutler, F. Koentgen, P. Lyons, K. Smith
Cambridge, United Kingdom
W1.10 - INNATE SENSORS
Chairs: Roman Jerala (SLO)
Cecilia Garlanda (ITA)
W3.14.05 - Contribution of IL-10 competent regulatory B cells (CD19+CD24hiCD38hi) to cytotoxic T lymphocyte dysfunction after reactivation of HIV latent
reservoirs.
Basile Siewe, S. Rygielski, S. Deeks, J. Martin, A. Landay
Chicago, USA
16.45-18.15
AMBER 7+8
16.45-18.15
BROWN 1
IL1.10.01 - The long pentraxin PTX3: a paradigm for
humoral pattern recognition molecules
Cecilia Garlanda
Rozzano, Italy
IL1.10.02 - Association of TIR domains underlying immunosuppression in bacterial infection and activation of MyD88 mediated cell signaling associated
with B-cell lymphoma
O. Fekonja, M. Avbelj, Roman Jerala
Ljubljana, Slovenia
Chairs: Riitta Lahesmaa (FIN)
Massimiliano Pagani (ITA)
W1.10.01 - Viral inhibition of DNA-PK-dependent
DNA sensing
Brian J. Ferguson, N.E. Peters, D.S. Mansur, M. Mazzon,
H. Ren, A.S. Fahy, E. Krysztofinska, R. Arribas-Bosacoma,
L.H. Pearl, G.L. Smith
Cambridge, United Kingdom
IL2.03.01 - Epigenomic and transcriptional regulation
of human Th cell differentiation
Riitta Lahesmaa
Turku, Finland
W1.10.02 - Hepatitis C virus degrades Riplet ubiquitin
ligase to escape host innate immune response
Hiroyuki Oshiumi, M. Matsumoto, T. Seya
Sapporo, Japan
W2.03 - EPIGENETIC CONTROL OF
IMMUNE RESPONSES
48
W2.03.04 - Loss of an Ig gene enhancer in mature B
cells results in rapid gene silencing and partial reversible de-differentiation
X. Zhou, Y. Xiang, William T. Garrard
Dallas, USA
W2.03.05 - Regulation of CD4 T helper cell differentiation and plasticity by the histone methyltransferase Ezh2
Damon J. Tumes, A. Onodera, C. Iwamura, H. Hosokawa,
H. Koseki, K. Tokoyoda, Y. Suzuki, T. Nakayama
Chiba, Japan
W3.14.03 - Aicda expression in immature B cells, but not
in mature B cells is critical for IgG autoantibody production in a model of systemic lupus erythematosus
Benjamin Umiker, A. Larbi, M. Reth, T. Honjo, T. ImanishiKari
Boston, USA
W3.14.06 - Human innate-like B cells with regulatory
properties in response to viruses
X. Zhang, Dania Zhivaki, S. Lemoine, A. Lim, C. Leclerc,
R. Lo-Man
Paris, France
W2.03.03 - The Polycomb group protein Ezh2 regulates the germinal center B cell response
Stefano Casola, M. Caganova, C. Carrisi, F. Zanardi,
F. Mainoldi, L. George, M. Ponzoni, K.M. Toellner, I. Su
Milan, Italy
Workshops August 24, 2013
W1.10.03 - Lysosomal DNase2a is required for the autophagic clearance of self damaged nuclear DNA
Yuk Yuen Lan, D. Londono, N. Hacohen
Charlestown, USA
W1.10.04 - Commensal microbiota monitoring by
RLRs regulates contact hypersensitivity response
Emilie Plantamura, L. Moudombi, S. Djebali, C. Macari,
S. Lippens, A. Dzutsev, G. Trinchieri, J. Marvel,
M.C. Michallet
Lyon, France
W1.10.05 - Essential role for Bruton’s tyrosine kinase
outside the B cell compartment in bacterial infection
Alex F. De Vos, J. Pater, R. De Beer, S. Terpstra,
C. Van ‘t Veer, R. Hendriks, T. Van Der Poll
Amsterdam, Netherlands
W1.10.06 - Genetic variants in donor PTX3 impair antifungal immunity and predispose to invasive aspergillosis after stem cell transplantation
C. Cunha, F. Aversa, A. Mantovani, L. Romani, Agostinho
Carvalho
16.45-18.15
BROWN 1
Perugia, Italy
49
Chair: Peter Parham (USA)
Peter C. Doherty (AUS)
Fifty years of cytotoxic T cells
PS.06 - PERSPECTIVES IN
IMMUNOLOGY
Chair: John Hamilton (USA)
Siamon Gordon (GBR)
Macrophage receptors and immune activation
PL.05 - PLENARY LECTURE
Chair: Alexander Rudensky (USA)
Maria Grazia Roncarolo (ITA)
Immune tolerance mediated by T regulatory
type 1 cells
LL.17 - LUNCHTIME LECTURE
Chair: David Wallach (ISR)
Peter Krammer (DEU)
Decisions of life and death
LL.19 - LUNCHTIME LECTURE
Chair: Paola Ricciardi Castagnoli (SNG)
Xuetao Cao (CHN)
Cross-regulation of innate inflammatory respons
12.30 - 13.15
BROWN 3
LL.15 - LUNCHTIME LECTURE
12.30 - 13.15
SPACE 1+2
Chair: Maria Grazia Roncarolo (ITA)
Shimon Sakaguchi (JPN)
Control of immune responses by regulatory T
cells
12.30 - 13.15
SPACE 4
12.30 - 13.15
GOLD ROOM
12.30 - 13.15
BROWN 1+2
12.30 - 13.15
SPACE 3
LL.16 - LUNCHTIME LECTURE
Chair: Antonio Lanzavecchia (CHE)
Andreas Radbruch (DEU)
The emerging diversity of immunological memory
LL.18 - LUNCHTIME LECTURE
Chair: Marco Cassatella (ITA)
Clifford A. Lowell (USA)
Tyrosine kinases and phosphatases in inflammation and autoimmunity
LL.20 - LUNCHTIME LECTURE
Chair: Douglas Golenbock (USA)
Ricardo Gazzinelli (BRA)
Toxoplasma recognition by TLR11/TLR12
heterodimers: a tale of mice (cats) and men
LL.21 - LUNCHTIME LECTURE
Chair: Gioacchino Natoli (ITA)
Joost Oppenheim (USA)
The defensin and HMGN1 alarmins have potent
adjuvant effects
18.30 - 19.15
GOLD ROOM
12.30 - 13.15
AMBER 1+2
50
8.50 - 9.20
SPACE 1+2
PS.05 - PERSPECTIVES IN
IMMUNOLOGY
9.30 - 10.15
GOLD ROOM
8.50 - 9.20
GOLD ROOM
Main Lectures August 25, 2013
PL.06 - PLENARY LECTURE
Chair: Marc Feldamann (GBR)
Antonio Lanzavecchia (CHE)
Dissecting the antibody response to pathogens
and self antigens
S13 - AUTOIMMUNE MECHANISMS
S14 - GENE AND CELL THERAPY
Chair:
Chairs: Adrian Thrasher (GBR)
Carlo Riccardi (ITA)
Paola Romagnani (ITA)
S14.01 Stem cell and kidney regeneration
Antonio Uccelli (ITA)
S14.02 Mesenchymal stem cells modulate the
immune response in vivo
Matthias Edinger (DEU)
S14.03 Regulatory T cells in allogeneic stem cell
transplantation
Masaru Taniguchi (JPN)
S14.04 NKT cells as an ideal target for anti-tumor
immunotherapy
Alessandro Aiuti (ITA)
S14.05 Gene therapy for primary
immunodeficiencies
Alberto Martini (ITA)
Eric Gershwin (USA)
S13.01 Primary biliary cirrhosis: the environment
and autoimmunity
Ethan Shevach (USA)
S13.02 Control of dendritic cell function by T
regulatory cells
Virginia Pascual (USA)
S13.03 Novel B cell-helper pathways in human SLE
Reinhold E. Schmidt (DEU)
S13.04 Innate mechanisms in antibody mediated
autoimmune diseases
David A. Hafler (USA)
S13.05 Regulatory T cells in autoimmune disease
10.20 - 12.25
SPACE 1+2
10.20 - 12.25
GOLD ROOM
Parallel Symposia August 25, 2013
S16 - ANTIGEN PROCESSING AND
PRESENTATION
Chairs: Martin Lipp (DEU)
Mario Mellado (ESP)
Philip M. Murphy (USA)
S15.01 Chemokines: tails from the clinic
Andrew D. Luster (USA)
S15.02 Chemokine guidance in the lymph node
imprints adaptive immune responses
Silvano Sozzani (ITA)
S15.03 Role of the atypical chemokine receptor
CCRL2 in immune responses
Klaus Ley (USA)
S15.04 Toward an antigen-specific therapy for
atherosclerosis
Kouji Matsushima (JPN)
S15.05 Dynamisms and regulation of tumorassociated myeloid cells
10.20 - 12.25
BROWN 3
10.20 - 12.25
BROWN 1+2
S15 - CELL TRAFFICKING
S18 - BACTERIAL INFECTIONS
10.20 - 12.25
SPACE 4
10.20 - 12.25
SPACE 3
S17 - COMPLEMENT AND SOLUBLE
MEDIATORS
Chairs: Marina Botto (GBR)
Mariagrazia Uguccioni (CHE)
John Lambris (USA)
S17.01 The Renaissance of Complement
Teizo Fujita (JPN)
S17.02 Functional aspect of the lectin
complement pathway
Seppo Meri (FIN)
S17.03 Trick or treat - how pathogens handle the
complement system
Francesco Tedesco (ITA)
S17.04 The complement system: friend or foe?
Paul Herzog (AUS)
S17.05 A unique type I interferon regulates
mucosal innate immune responses in the female
reproductive tract
Chairs: Emil Unanue (USA)
Kenneth Rock (USA)
Jacques Neefjes (NLD)
S16.01 Genome-wide analyses defines new
factors controlling MHC class I and MHC class II
antigen presentation
Peter Cresswell (USA)
S16.02 Molecular aspects of MHC
class I-restricted antigen processing
Jose Villadangos (AUS)
S16.03 Regulation of antigen presentation in the
dendritic cell network
Sebastian Amigorena (FRA)
S16.04 Antigen crosspresentation in dendritic cells
Muriel Moser (BEL)
S16.05 Regulatory T cells control Th1 priming by
inhibiting CD70 expression: a role for
intercellular transfer of CD27?
Chairs: Francesco Dieli (ITA)
Giuseppe Teti (ITA)
Russell E. Vance (USA)
S18.01 Activation of inflammasomes by bacterial
pathogens
Jurgen Ruland (DEU)
S18.02 CARD9 signaling complexes in innate
immunity
Robert L. Modlin (USA)
S18.03 Type I interferon suppresses type II
interferon-triggered human anti-mycobacterial
responses
Francesco Dieli (ITA)
S18.04 HLA-E-restricted recognition of
Mycobacterium
tuberculosis by human CD8 T lymphocytes
Willem Hanekom (ZAF)
S18.05 Human correlates of risk of TB disease
51
Sponsored Sessions August 25, 2013
13.30 - 15.00
SPACE 3
12.30 - 15.10
AMBER 5+6
STANDARDIZATION IN IMMUNOLOGY. IMPORTANCE FOR HEALTH AND DISEASE
IUIS Lunch Symposium
Chair: Rudolf Valenta (AUT)
Ruby Pawankar (JPN)
Importance of standardization in immunology and allergy: a WAO perspective
Stefan Vieths (DEU)
Major allergen ELISA’s and recombinant allergens in allergens standardization
Luis Andrade (BRA)
The impact of different methodological platform and standards in the diagnostic performance of autoantibodies
Alberto Falorni (ITA)
Standardization of adrenal autoantibody determination in Europe
Pablo Engel (ESP)
CD molecules. Standardization of monoclonal antibody validation
Michael Kirschfink (DEU)
Modern complement analysi
Vladka urin Šerbec (SLO)
Goals and challenges and its impact on the immunological diagnostics
Clemens Scheinecker (AUT)
The Subcommittee for the Standardization and Quality Assesment in Immunotherapy: the need for expert opinions
INNOVATIVE FLOW CYTOMETRY TO DECIPHER IMMUNE CELL FUNCTION
with the contribution of BD Bioscience
Chair: Robert Balderas (USA)
Jurg Rohrer (USA)
Innovative tools to incorporate low density antigens in multicolor panels
Claudia Mauri (GBR)
Regulatory B cells maintain regulatory T cells whilst inhibiting Th17 and Th1 differentiation
15.10 - 16.40
SPACE 1
13.30 - 15.00
SPACE 4
INFECTIOUS AGENTS AND AUTOIMMUNITY - PART II
with the contribution of Italian Ministry of Health and Italian Multiple Sclerosis Foundation
Chairs: Francesca Aloisi (ITA) - Christian Münz (CHE)
Patrick J. Venables (GBR)
Porphyromonas gingivalis and autoimmunity in rheumatoid arthritis
Jan Lünemann(CHE)
Virus-host interactions in multiple sclerosis
Francesca Aloisi (ITA)
Epstein-Barr virus and lymphoid neogenesis in autoimmunity
Christian Münz (CHE)
Translational aspects and discussion
PRIMARY BILIARY CIRRHOSIS: GENETICS, PATHOGENESIS AND THERAPY
OF A PROTOTYPIC AUTOIMMUNE DISEASE
with the contribution of Intercept Pharmaceuticals
Chair: Luciano Adorini (ITA)
Pietro Invernizzi (ITA)
Recent progress in genetics and epigenetics of PBC
M. Eric Gershwin (USA)
Environmental factors and the pathogenesis of PBC
David Shapiro (USA)
New therapies for PBC
19.15 - 20.15
GOLD ROOM
15.10 - 17.10
SPACE 3
NEW INSIGHTS IN CHEMOKINE ALLOSTERIC INHIBITORS
52
With the contribution of Dompé S.p.A.
Chair: Mauro Teixeira (BRA)
David Scholten (NLD)
Pharmacological modulation of chemokine receptors function
Mette Rosenkilde (DEN)
Major players in 7TM receptor activation; structural features of chemokine receptors
Massimo Locati (ITA)
Dissecting trafficking and signaling of typical and atypical chemokine receptors
Marcello Allegretti (ITA)
A structurally conserved allosteric motif beyond the chemokine receptor family
ELSE KRÖNER-FRESENIUS AWARD LECTURE
Welcome note: Susanne Schultz-Hector, executive board Else Kröner-Fresenius-Stiftung
Introduction: S.H.E. Kaufmann, IUIS president
Award lecture by the winner of the Else Kröner-Fresenius-Award
Workshops August 25, 2013
W3.13 - REGULATORY T CELLS:
BASIC ASPECTS
Stefano Angiari, B. Rossi, L. Piccio, B.H. Zinselmeyer,
S.L. Budui, E. Zenaro, V. Della Bianca, A.H. Cross,
M.J. Miller, G. Constantin
Verona, Italy
Chairs: Hans-Jorg Schild (DEU)
Barbara Fazekas de St Groth (AUT)
W3.13.10 - Visualizing tolerance induction: behavior
and function of regulatory T cells during the establishment of materno/fetal tolerance
Maria-Grazia G. Ruocco, T. Chen, G. Darrasse-Jeze,
D. Klatzmann
Paris, France
IL3.13.01 - Regulatory T cells fine-tune DC costimulation in vivo to set the threshold for T cell activation
Barbara Fazekas de St Groth, H. Bolton, C. Zhu
Sydney, Australia
W3.13.01 - Low/negative expression of CD6 in natural T-regulatory cells
Carlos A. Garcia Santana, J.W. Tung, S. Gulnik
Miami, United States
W3.13.02 - Regulatory T cells increase the avidity of
CD8+ T cell responses to non-self antigens and promote memory
Luigia Pace, A. Tempez, C. Arnold-Schrauf, F. Lemaitre,
P. Bousso, L. Fetler, T. Sparwasser, S. Amigorena
Paris, France
15.10-18.15
GOLD ROOM
IL3.13.02 - Impaired peripheral tolerance as a consequence of disturbed regulatory T cells - dendritic cell
interactions
Hansjörg Schild, S. Muth, H. Probst
Mainz, Germany
W3.13.14 - TCR-independent CD4+CD25+ regulatory T
cell activation during immune responses
Hidefumi Kojima, Y. Kashiwakura, M. Hashiguchi,
T. Kobata
Mibu, Japan
W3.13.05 - TGF- signalling is required for CD4+ T cell
homeostasis but dispensable for regulatory T cell
function
Anna Sledzinska, S. Hemmers, F. Mair, O. Gorka,
J. Ruland, L. Fairbairn, W. Müller, A. Waisman, B. Becher,
T. Buch
Zurich, Switzerland
W3.13.08 - Selective inhibition of pro-inflammatory
T cell responses by TIGIT+ Tregs
Nicole Joller, S. Xiao, B. Patel, C. Zhu, J. Xia, F.J. Quintana,
V.K. Kuchroo
Boston, USA
W3.13.09 - Regulatory T cells suppress the late phase
of the immune response in lymph nodes through Pselectin glycoprotein ligand-1
W4.03 - HIV PATHOGENESIS AND
IMMUNITY
Chairs: Guido Poli (ITA)
Andrea Cossarizza (ITA)
IL4.03.01 - The Fight Between HIV Infection and
Macrophage Polarization
Guido Poli
Milano, Italy
15.10-18.15
BROWN 3
15.10-18.15
GOLD ROOM
W3.13.04 - Continuous interactions with self are required for maintaining regulatory CD4 T cell numbers
and suppressive capacities in the periphery
Arnaud Delpoux, P. Yakonowsky, A. Pommier, C. Charvet,
M. Valente, A. Durand, B. Martin, C. Auffray, B. Lucas
Paris, France
W3.13.07 - Human regulatory T cells rapidly suppress
T cell receptor-induced calcium, NF-B, and NFAT signalling in conventional T cells
Angelika Schmidt, N. Oberle, R. Joshi, S. Frischbutter,
R. Baumgrass, H. Lin, G.W. Mayr, E. Suri-Payer, J. Tegner,
P.H. Krammer
Solna, Sweden
W3.13.12 - Der P 1 induced CD4+FOXP3+GATA3+ T cells
have suppressive properties while contributing to
the polarization of the Th2 response
Lieke L. Reubsaet, J. Meerding, R. Giezeman, I.M. de
Kleer, H.G.M. Arets, B.J. Prakken, J. Beekman, F. van Wijk
Utrecht, Netherlands
W3.13.13 - Highly pure human antigen-specific Tregs
with superior function in preventing allograft rejection
Fatih Noyan, M. Hardtke-Wolenski, Y. Lee, R. Taubert,
G. Warnecke, A. Knoefel, E. Schulde, S. Olek, M.P. Manns,
E. Jaeckel
Hannover, Germany
W3.13.03 - Costimulatory requirements for Treg
homeostasis and function
C. Wang, R. Kenefeck, L. Wardzinski, Lucy S. Walker
London, United Kingdom
W3.13.06 - Essential role for Bcl11b in the FoxP3 transcriptional complex and T regulatory cells suppressive function
Masahide Hamaguchi, K. Sakai, N. Ohkura,
H. Morikawa, Y. Shimazu, J.B. Wing, S. Sakaguchi
Suita, Japan
W3.13.11 - Migratory, and not lymphoid-resident,
dendritic cells maintain peripheral self-tolerance and
prevent autoimmunity via induction of iTreg cells
Achille Broggi, C. Vitali, F. Mingozzi, S. Barresi,
G. Raimondi, I. Zanoni, F. Granucci
Milan, Italy
W4.03.01 - Endoplasmic reticulum aminopeptidase 2
(ERAP2) haplotypes play a role in antigen presentation and resistance to HIV-1 infection
Irma Saulle, M. Biasin, F. La Rosa, M. De Luca,
D. Trabattoni, M. Sironi, R. Cagliani, F. Mazzotta,
S. Lo Caputo, M. Clerici
Milan, Italy
W4.03.02 - Molecular characterization of high avidity
CD4+ T cells in HIV controllers
Daniela Benati, M. Galperin, O. Lambotte, A. Lim,
B. Lemercier, S. Hendou, F. Boufassa, J. Delfraissy,
F. Arenzana-Seisdedos, L. Chakrabarti
Paris, France
W4.03.03 - Characterization of HIV-1 specific T cell response in an Italian cohort of HIV-1 natural controllers
Davide De Battista, D. Mennonna, S. Heltai,
E. De Martino, A. Riva, M. Tinelli, S. Nozza, S. Ghezzi,
G. Poli, M. Malnati
Milan, Italy
53
W4.03.04 - NK cells in HIV controller patients express
an activated effector phenotype and do display unique NKp46,NKp30,NKp44 modulation on IL-2 stimulation
Francesco Marras, E. Nicco, F. Bozzano, A. Di Biagio,
C. Dentone, G. Orofino, F. Bisio, A. Riva, L. Moretta,
A. De Maria.
Genoa, Italy
15.10-18.15
BROWN 3
Workshops August 25, 2013
W2.06 - LEUKOCYTE TRAFFICKING
W4.03.05 - Inhibition of human immunodeficiency
virus type-1 replication in CD4+ NKT cells by T lymphocytes
Kyoko Omi, M. Shimizu, E. Watanabe, A. Owaki,
C. Takaku, E. Shinya, H. Takahashi
Tokyo, Japan
Chairs: Ruggero Pardi (ITA)
Giorgio Berton (ITA)
W2.06.01 - Clathrin light chain subunits control actin
organization during infection and lymphocyte migration
Frances M. Brodsky, M. Bonazzi, P. Cossart, P. Parham,
S. Majeed
San Francisco, USA
W4.03.06 - Immune exposure to a specific sequence
of antibody escape variants could program long-term
potential for neutralization breadth in subtype A
HIV-1 infection
Megan K. Murphy, L. Yue, R. Pan, A. Sethi, E. Karita, S.A.
Allen, J.E. Robinson, S. Gnanakaran, X. Kong, C.A. Derdeyn
Atlanta, USA
W4.03.08 - Telomere length and CD38 expression on
monocytes and CD8 T cells of HIV infected people
Maciej Tarkowski, D. Misciagna, F. Strambio de Castillia, C.
Gervasoni, C. Resnati, L. Ferraris, R. Piolini, M. Galli, A. Riva
Milan, Italy
W2.06.02 - DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses
Yousuke Harada, Y. Tanaka, M. Terasawa, J.V. Stein,
T. Kinashi, Y. Fukui
Fukuoka, Japan
15.10-16.40
SPACE 2
15.10-18.15
BROWN 3
W4.03.07 - Decrease of CD73 expressing CD8 T cells
in the course of HIV infection correlates with immune
activation and T cell exhaustion
Ilona Tóth, A.Q. Le, P. Hartjen, A. Thomssen, C. Beisel,
A.W. Lohse, J. Hauber, J. van Lunzen, J.C.R. Schulze zur
Wiesch
Hamburg, Germany
W4.03.09 - HIV-1 infection impairs CD34+ hematopoietic progenitor cells differentiation toward dendritic cells
Veronica Bordoni, D. Viola, A. Sacchi, G. Castelli,
M. Bibas, A. Ammassari, C. Agrati, A. Amendola,
I. Abbate, F. Martini
Rome, Italy
54
W2.06.04 - The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate
A. Mendoza, B. Breart, W.D. Ramos-Perez, L.A. Pitt,
M. Gobert, M. Sunkara, J.J. Lafaille, A.J. Morris,
Susan R. Schwab
New York, USA
W2.06.06 - A mechanism of the skin-infiltration of basophils that is essential for the acquired protective
immunity to tick infestation
Soichiro Yoshikawa, T. Ohta, K. Ishiwata, K. Horiguchi,
L. Li, K. Miyake, Y. Kawano, H. Kanuka, N. Watanabe,
H. Karasuyama
Tokyo, Japan
15.10-16.40
SPACE 4
W4.03.11 - HIV-infected T cells are migratory vehicles
for viral dissemination
Thomas T. Murooka, M. Deruaz, F. Marangoni,
V. Vrbanac, E. Seung, U. von Andrian, A. Tager, A. Luster,
T.R. Mempel
Boston, USA
W4.03.13 - Trogocytosis between germinal center B
cells and TFH cells during acute SIV infection of macaques
Ankita Chowdhury, P.M. Del Rio Estrada, M. Reuter,
N. Patel, T. Hayes, S.E. Bosinger, J.D. Estes, M. Paiardini,
M. Betts, G. Silvestri
Atlanta, USA
W2.06.03 - All-trans retinoic acid and rapamycin synergize with transforming growth factor- to induce
regulatory T cells but confer distinct in vivo migratory capacities
Giorgio Raimondi, S. Jhunjhunwala, L.C. Chen,
E.E. Nichols, Y.T. Nicholson, A.W. Thomson, S.R. Little
Baltimore, USA
W2.06.05 - D6 is a -arrestin-biased signalling chemokine scavenger receptor
Cinzia Cancellieri, E.M. Borroni, A. Vacchini, Y. Benureau,
F. Bachelerie, F. Arenzana-Seisdedos, K. Mizuno,
A. Mantovani, R. Bonecchi, M. Locati
Milan, Italy
W4.03.10 - Over-production of BAFF by dendritic cells
and inflammatory monocytes during primary HIV-1
infection
Gwenoline Borhis, N. Chaoul, C. Gilbert, C. Gras, C. Goujard, L. Meyer, S. Paul, H. Saoudin, J. Herbeuval, Y. Richard
Paris, France
W4.03.12 - TLR3 activation on dendritic cells causes
complete suppression of HIV-1 infected dendritic cells
by inducing up-regulation of microRNA-155 and APOBEC-3G
Fiorella P. Rossi, G. Swaminathan, J. Martin-Garcia
Philadelphia, USA
W4.03.14 - Characterization of XCR1+ dendritic cells
in healthy and SIV-infected rhesus macaques
Charles-Antoine Dutertre, J. Jourdain, M. Rancez,
S. Amraoui, Y. Richard, M. Dalod, V. Feuillet, R. Cheynier,
A. Hosmalin
Paris, France
W1.14 - CYTOKINES AND OTHER
REGULATORY MEDIATORS OF
INFLAMMATION
Chairs: Francesca Fallarino (ITA)
Fernando Q. Cunha (BRA)
IL1.14.01 - Endotoxin tolerance as a novel defence
strategy in infectious diseases
Francesca Fallarino, M. Gargaro, A. Bessede, D. Matino,
G. Servillo, L. Tissi, L. Romani, U. Grohmann, P. Puccetti
Perugia, Italy
Workshops August 25, 2013
15.10-16.40
SPACE 4
W1.14.02 - The BAFF/Th17 axis in Helicobacter pylori
infection
Fabio Munari, M. Fassan, M. Cassatella, M. de Bernard
Padua, Italy
W1.14.03 - Molecular basis of signalling through the
IL-36 receptor
Eric J. Sundberg
Baltimore, USA
15.10-16.40
AMBER 1+2
W1.14.01 - Expression and regulation of IL-35 in
human tolerogenic dendritic cells and its role in regulating T cells responses
Karen O. Dixon, S. van der Kooij, N. Schlagwein,
D. Vignali, C. van Kooten
Leiden, Netherlands
W6.07.04 - Gene therapy mediated by lentiviral vector transduced CD34+ cells for the treatment of Wiskott-Aldrich syndrome
Samantha Scaramuzza, F. Ferrua, M.C. Castiello,
S. Giannelli, L. Biasco, F. Ciceri, M.G. Roncarolo, A. Villa,
L. Naldini, A. Aiuti
Milan, Italy
W6.07.05 - Multifunctional CD26hi Th17 cells eradicate
large human tumors
Michelle H. Nelson, L. Huff, S. Kundimi, M. Goodyear,
S.R. Bailey, C.M. Paulos
Charleston, USA
W6.07.06 - Identification of an alternative specificity
for engineered T cells expressing an enhanced affinity MAGE-A3 TCR
Bent K. Jakobsen, B.J. Cameron, A.B. Gerry, J. Dukes,
J.V. Harper, E.A. Stadtmauer, A.P. Rapoport, C.H. June,
N.J. Hassan, M. Kalos
Abingdon, United Kingdom
W1.14.04 - Intracellular signalling involved in IL-22 release by dendritic cells
Maria Foti, S. Fumagalli, S. Citterio, C. Ripamonti
Milan, Italy
W1.14.05 - Environmental conditions perceived by
the brain alter CD4+ T cell responses through an adiponectin-dependent mechanism
Magdalena M. Canali, J.A. Soria, E. Murris, J. Chabry,
A. Guyon, A. Paitel, N. Zsürger, E. Mougneau, N. Glaichenhaus
Sophia Antipolis, France
W3.05 - ANTIGEN PROCESSING AND
PRESENTATION
Chairs: Kayo Inaba (JPN)
Peter van Endert (FRA)
IL3.05.01 - Compartment cross-talk controlling
phagosome maturation and exogenous antigen presentation in dendritic cells
Peter van Endert, M. Weimershaus, J. Babdor,
D. Descamps, A. Lennon-Dumenil, M. Zwick, T. Brocker,
L. Saveanu
Paris, France
W1.14.06 - The non-specific and sex-differential immunological effects of the Bacillus Calmette-Guerin
(BCG) vaccine in infants
Kristoffer J. Jensen, N. Larsen, S. Biering-Sørensen,
H.B. Eriksen, M.J. Jørgensen, D. Hougaard, K. Flanagan,
P. Aaby, C.S. Benn
Copenhagen, Denmark
W3.05.01 - The true story of how MHC peptides are
produced
Arie Admon, L. Gutter-Kapon, E. Milner, D. Bourdetsky,
E. Barnea, I. Beer
Haifa, Israel
W6.07 - CELL-BASED THERAPY
15.10-16.40
AMBER 1+2
IL6.07.01 - Cell therapy to induce tolerance: which cell
type should we use?
Giovanna Lombardi, R. Lechler
London, United Kingdom
W6.07.01 - Human CD8+ regulatory T cells inhibit
GVHD and preserve general immunity in humanized
mice
Jian Zheng, Y. Liu, Y. Liu, M. Liu, Z. Xiang, K. Lam,
D.B. Lewis, Y. Lau, W. Tu
Hong Kong, Hong Kong
W6.07.02 - Therapeutic efficacy of human mesenchymal stromal cells in a humanised mouse model of
acute GVHD
Karen English, L. Tobin, M. Healy, B.P. Mahon
Co Kildare, Ireland
W6.07.03 - Induction of donor-specific tolerance in
organ transplantation using in vitro-generated immunosuppressive myeloid blood cells
Christian Kleist, F. Sandra-Petrescu, L. Jiga, L. Dittmar,
E. Mohr, J. Greil, G. Opelz, P. Terness
Heidelberg, Germany
15.10-16.40
AMBER 3+4
Chairs: Giovanna Lombardi (GBR)
Hideki Ueno (USA)
W3.05.02 - ER-resident editors optimize distinct features of the peptide cargo loaded onto MHC-I molecules
T. Kanaseki, K.C. Lind, H. Escobar, N. Nagarajan, E. ReyesVargas, B. Rudd, L. Van Kaer, N. Sato, J. Delgado, Nilabh
Shastri
Berkeley, USA
W3.05.03 - A CD74-dependent MHC-I endolysosomal
cross-presentation pathway
Wilfred A. Jefferies, G. Basha, K.D. Omilusik, A. ChavezSteenbock, A.T. Reinicke, N. Lack, K. Choi
Vancouver, Canada
W3.05.04 - IRAP endosomes are an intracellular crossroad of innate and adaptive immunity
Loredana Saveanu, M. Weimershaus, J. Babdor,
M. Tohme, P. Vargas, A. Lennon-Dumenil, D. Descamps,
B. Manoury, P. van Endert
Paris, France
W3.05.05 - CD4 T cell receptor transgenic mice recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes
James F. Mohan, B. Calderon, E.R. Unanue
Saint Louis, USA
55
15.10-16.40
AMBER 3+4
Workshops August 25, 2013
W3.05.06 - Structural basis of human beta-cell killing
by CD8+ T cells in type 1 diabetes
David K. Cole
Cardiff, United Kingdom
W5.03.01 - Effect of multiple genetic risk factors associated with rheumatoid arthritis on immune cell
phenotypes
Lucia Chovanova, M. Vlcek, K. Krskova, F. Spoutil,
J. Rovensky, R. Brownlie, R. Zamoyska, R. Imrich
Bratislava, Slovakia
W5.03.02 - Variants in the IRF5-TNPO3 locus are associated with the development of lupus and its clinical
presentation and shared with other autoimmune disorders
Leah C. Kottyan, E.E. Zoller, S. Hawtrey, K.M. Kaufman,
J.B. Harley
Cincinnati, USA
W3.08 - Th1 AND Th2 CELLS
Chairs: Enrico Maggi (ITA)
W3.08.01 - Crucial role of IL-18R1 signalling in Th1 cell
differentiation in mice infected with Trypanosoma
cruzi
A. Oliveira, A.P. Granato, J.F. Gomes-Neto, C.H.D. Barbosa,
F.B. Canto, R. Fucs, A. Nobrega, Maria Bellio
Rio de Janeiro, Brazil
15.10-16.40
AMBER 5+6
W3.08.02 - Pro- and anti-inflammatory cytokine signals control the balance between Th1 and Tfh differentiation during the first few days of viral
infection
Heather D. Marshall, I.A. Parish, M. Staron, B.J. Laidlaw,
J. Ray, J. Craft, S.M. Kaech
New Haven, USA
15.10-16.40
AMBER 7+8
Barbara Bohle (AUT)
W3.08.03 - CD4+ T cells are both trigger and target of
the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection
D.G. Kugler, P.R. Mittlesstadt, J.D. Ashwell, A. Sher,
Dragana Jankovic
Bethesda, USA
W5.03.06 - Vav1 cooperate with Themis to modulate
regulatory T cell suppressive functions
Christophe Pedros, M. Chabod, A. Dejean, I. Bernard,
O. Andreoletti, G. Fournié, A. Saoudi
Toulouse, France
W3.08.05 - RNA-binding protein HuR coordinately regulates GATA-3 and CD4+ Th2 cytokine gene expression in dose-dependent manner
Ulus Atasoy, M. Gubin, R. Calaluce, J. Martindale,
M. Gorospe, C. Stellato, V. Casolaro
Columbia, USA
15.10-16.40
AMBER 7+8
Chairs: Rosa Sorrentino (ITA)
Manfred Herold (AUT)
IL5.03.01 - HLA-B27 micropolymorphisms correlate
with differences in function and susceptibility to
Ankylosing Spondylitis
M.T. Fiorillo, V. Tedeschi, C. Vitulano, F. Paladini, G. Camilli,
C. Rossetti, S. Tuncer, Rosa Sorrentino
Roma, Italy
W1.08 - DENDRITIC CELL SUBSETS
Chairs: Michel Gilliet (CHE)
Franca Ronchese (NZL)
IL1.08.01 - Increased numbers of monocyte-derived
DC in the lymph node during successful tumor treatment with immune activating agents
S. Kuhn, E. Hyde, F. Rich, J. Harper, J. Kirman, Franca
Ronchese
Wellington, New Zealand
15.10-16.40
BROWN 1
W5.03 - GENETICS OF AUTOIMMUNITY
W5.03.04 - Genetic variants in PXK are associated
with the development of lupus and critically regulate
BCR internalization
Samuel E. Vaughn, I.T.W. Harley, C. Foley, L.C. Kottyan,
K.M. Kaufman, J.A. Kelly, J.B. Harley
Cincinnati, USA
W5.03.05 - Enhanced apoptosis by disruption of the
STAT3-IB- signalling pathway in epithelial cells induces Sjögren’s syndrome-like autoimmune disease
A. Okuma, K. Hoshino, T. Kaisho, Tatsushi Muta
Sendai, Japan
W3.08.04 - Blimp-1 triggers the formation of immunoregulatory IL-10 producing Th1 cells during chronic
viral infection
Ian A. Parish, H.D. Marshall, P.A. Lang, A. Brustle,
J.H. Chen, W. Cui, P.S. Ohashi, C.T. Weaver, S.M. Kaech
Canberra, Australia
W3.08.06 - Modifications of the bone marrow microenvironment in the transition from monoclonal gammopathy of undetermined significance to multiple
myeloma in Vk*MYC mice
Arianna Calcinotto, E. Cattaneo, M. Grioni, S. Bertilaccio,
M. Chesi, L. Bergsagel, G. Casorati, P. Dellabona, M. Bellone
Milan, Italy
W5.03.03 - The lupus-associated variant of the
ITGAM allele (rs1143679) impairs phagocytosis, but
not migration nor TLR7/8 induced cytokine release
Liliane Fossati-Jimack, G.S. Ling, A. Cortini, M. Szajna,
T.H. Malik, J.U. McDonald, M.C. Pickering, H.T. Cook,
P.R. Taylor, M. Botto
London, United Kingdom
W1.08.01 - Characterization of human afferent lymph
dendritic cells from seroma fluids
Barbara Morandi, I. Bonaccorsi, R. Conte, G. Costa,
R. Iemmo, S. Ferrone, C. Cantoni, M. Mingari, L. Moretta,
G. Ferlazzo
Genoa, Italy
W1.08.02 - Plasmacytoid, conventional and monocyte-derived dendritic cells undergo a profound and
convergent genetic reprogramming during their maturation
T. Vu Manh, Y. Alexandre, T. Baranek, K. Crozat,
Marc Dalod
Marseille, France
W1.08.03 - The dendritic cells of the bone marrow
Ben R. Fancke, J. Pooley, M. O’Keeffe
Melbourne, Australia
56
Workshops August 25, 2013
W1.16 - COMPLEMENT SYSTEM
Chairs: Anna Erdei (HUN)
George N. Hajishengallis (USA)
IL1.16.01 - Microbial manipulation of select host signaling pathways to disengage immune bacterial
clearance from inflammation
George Hajishengallis, T. Maekawa, J.L. Krauss,
K.B. Hosur, J.D. Lambris
Philadelphia, United States
W1.08.05 - In vivo roles of XC chemokine receptor 1expressing dendritic cells
Tomokazu OHTA, H. Hemmi, C. Yamazaki, M. Sugiyama,
I. Sasaki, K. Hoshino, T. Kaisho
Suita, Japan
+
W1.16.01 - C3 opsonisation enhances apoptotic cellassociated antigen presentation by DCs by controlling the endocytic handling
Lucie Baudino, A. Sardini, M. Ruseva, L. Fossati-Jimack,
D. Scott, T. Cook, M. Botto
London, United Kingdom
-
W1.08.06 - Resident CD11b Ly6C lung dendritic cells
are responsible for allergic airway sensitization to
house dust mite in mice
C. Mesnil, C.M. Sabatel, T. Marichal, M. Toussaint,
D. Cataldo, P. Drion, P. Lekeux, F. Bureau, Christophe J.
Desmet
Liège, Belgium
W7.02 - SYSTEMS AND THEORETICAL
IMMUNOLOGY
Chair:
Kendall A. Smith (USA)
W7.02.01 - Methodological applications of host-pathogen data profiles conserved in evolution
Ariel L. Rivas, M.D. Jankowski, G. Leitner, D. Schwarz,
J.M. Fair, A.L. Hoogesteijn, J.B. Hittner, J.M. Hyman,
D.J. Perkins
Albuquerque, USA
16.45-18.15
SPACE 4
15.10-16.40
BROWN 1
W1.08.04 - Unraveling the fingerprint of human tolerogenic DC-10, a dendritic cell subset involved in
the establishment of peripheral tolerance
M. Comi, D. Tomasoni, M. Villa, M. Pala, M. Floris,
A. Bulfone, M. Roncarolo, Silvia Gregori
Milan, Italy
W1.16.05 - Role of the long Pentraxin PTX3 in fibrosarcoma development and progression
Eduardo Bonavita, S. Gentile, N. Polentarutti, F. Feruglio,
F. Pasqualini, M. Nebuloni, S. Jaillon, A. Mantovani,
C. Garlanda
Milan, Italy
W7.02.03 - Functional proteomic interrogation of immune cell crosstalk and the effects of cytokine-targeted inhibitors using Single Cell Network Profiling
D. Hotson, A. Conroy, A. Cesano, Rachael Hawtin
San Francisco, USA
W1.16.06 - Dendritic cell alternative pathway production is differentially regulated by interferons and IL27
Joseph O`Flynn, K. Dixon, N. Klar Mohamad, M.R. Daha,
C. van Kooten
Leiden, Netherlands
W7.02.04 - Comparison of functional immune signalling profiles in peripheral blood mononuclear cells
from rheumatoid arthritis patients versus healthy donors using Single Cell Network Profiling
J. Ptacek, R. Hawtin, E. Evensen, J. Cordeiro, M. Atallah,
C. Marimpietri, A. Cesano, TETRAD Investigators,
P.K. Gregersen, S.Lou Bridges
San Francisco, USA
W6.08 - STEM CELLS IN IMMUNITY
W7.02.05 - The role of microRNAs in regulatory T cell
function
C.Y. Brown, T. Sadlon, S. Pederson, G.T. Goodall, M. Beyer,
J. Schultze, Simon C. Barry
Adelaide, Australia
Chairs: Luca Gattinoni (USA)
Francesco Frassoni (ITA)
16.45-18.15
AMBER 1+2
15.10-16.40
BROWN 2
W1.16.03 - Response gene to complement-32 mediates C5b-9 induced cell cycle activation and migration
in endothelial cells
Cosmin A. Tegla, C.D. Cudrici, T. Ito, V. Nguyen, V. Rus,
F. Niculescu, H. Rus
Baltimore, USA
W1.16.04 - Soluble GC1QR is an autocrine signal
which induces bradykinin receptor 1 expression on
activated endothelial cells
Berhane Ghebrehiwet, Y. JI, K. Hosszu, A. Valentino,
E.I.B. Peerschke
Stony Brook, USA
W7.02.02 - Higher expression of genes related to B
cell activation in female spleen cells
R. Godínez-Aguilar, E. Aguirre-von-Webesser, V. Bermúdez,
E. Lamoyi, J. Berumen, José Moreno
Cuernavaca, Mexico
W7.02.06 - A bioinformatics pipeline to uncover regulatory modules and their condition-specific regulators
in
human
monocyte-to-macrophages
differentiation and polarization
Emilia M.C. Mazza, P. Italiani, S. Valsoni, I. Cifola,
D. Boraschi, C. Battaglia, S. Bicciato
Modena, Italy
W1.16.02 - Follicular dendritic cells are essential for
maintenance of autoreactive B cells
B.A. Heesters, P. Chatterjee, N. Dwivedi, A. Das, Michael
C. Carroll
Boston, USA
IL6.08.01 - Harnessing stem-cell like memory T cells
for adoptive cell transfer therapy of cancer
Luca Gattinoni
Bethesda, United States
W6.08.01 - Potential roles for adipose-derived mesenchymal stem cells in the regulation of the mucosal
immune system in aging
K. Aso, K. Kimura, K. Takagaki, T. Kobayashi, K. Oki,
S. Sugimoto, H. Tanemura, N. Urushihata, J.R. McGhee,
Kohtaro Fujihashi
Birmingham, USA
57
W6.08.02 - Clinical effects of intraperitoneal mesenchymal stem cells and mesenchmal stem cells-derived
neural progenitor cells in a chronic experimental
model of multiple sclerosis
Fateme Nasri, T. Kalantari, M.S. Mohtasebi, F. Taki,
E. Kamali Sarvestani
Shiraz, Islamic Republic of Iran
16.45-18.15
AMBER 1+2
W6.08.03 - IFN- impairs the self-renewal of hematopoietic stem cells during viral infection
A.M. de Bruin, B. Hooibrink, Martijn A. Nolte
Amsterdam, Netherlands
16.45-18.15
AMBER 3+4
Workshops August 25, 2013
W6.08.04 - Mouse compact bone derived mesenchymal stem cells supress airway inflammation in both
chronic and acute murine asthma model
I. Ogulur, G. Gurhan, A. Aksoy, G. Duruksu, D. Filinte,
I. Barlan, E. Karaöz, Tunç Akkoç
Istanbul, Turkey
Chairs: Thomas Hunig (DEU)
Dario Vignali (USA)
IL5.06.01 - The CD28 superagonist TGN1412: After the
storm
Thomas Hünig
Würzburg, Germany
IL5.06.02 - Molecular Control of Treg Stability and
Function
Dario Vignali
Memphis, United States
W6.08.06 - The acquisition of immunomodulating
properties by mouse mesenchymal stem cells in presence of IFN- is associated with a reduced expression
of Nanog and alteration of their differentiation potential
Tiziana Vigo, C. Procaccini, G. Matarese, S. Baranzini,
N. Kerlero de Rosbo, A. Uccelli
Genoa, Italy
W5.06.01 - TRAF6 is essential for maintenance of regulatory T cells and suppression of Th2 type inflammation
Go Muto, R. Morita, S. Niikura, H. Kotani, T. Kobayashi,
A. Yoshimura
Tokyo, Japan
16.45-18.15
AMBER 3+4
W5.06.02 - Breakdown of immune tolerance by quantitative and qualitative alterations of ZAP-70
Atsushi Tanaka, S. Maeda, T. Nomura, S. Tanaka, L. Jin,
S. Akizuki, N. Sakaguchi, R. Zamoyska, D.M. Standley, S.
Sakaguchi
Osaka, Japan
W5.06.03 - KLRG1 expression in ICOS+Foxp3+ Treg
cells delineates a functionally fatigued Treg subset
during T1D progression in NOD mice
Mara Kornete, C. Piccirillo
Montreal, Canada
W3.04.01 - A novel DNA break and phosphorylationdependent positive feedback loop promotes class
switch recombination
Jayanta Chaudhuri
New York, USA
W5.06.04 - B cell derived IFN- contributes to the negative regulation of T regulatory cell differentiation
in arthritis
Susan A. Olalekan, Y. Cao, T. Glant, A. Finnegan
Chicago, USA
W3.04.02 - AID-dependent IgV hypermutation requires a splice isoform of the SR protein SRSF1
Naoki Kanayama, Y. Kanehiro, K. Todo, Y. Kawaguchi,
S. Miyazaki, K. Watanabe, H. Tokumitsu, J.L. Manley, M.
Magari, H. Ohmori
Okayama, Japan
W5.06.05 - The in vivo impact of CD25 blockade on
human regulatory T cells and evidence for compensatory maintenance by IL2R and IL7R signalling
D. Huss, D. Mehta, A. Sharma, L. Amaravadi, J. Elkins,
Jason D. Fontenot
Cambridge, USA
W3.04.03 - Effect of the 3’Regulatory Region insulation on B cell development and DNA rearrangements
at the immunoglobulin heavy chain locus
F. Braikia, Caroline Conte, M. Moutahir, A. Khamlichi
Toulouse, France
W5.06.06 - Restoration of normoglycemia in diabetic
NOD mice by oral L. lactis secreting human pro-insulin plus IL-10 combined with short-term low-dose
anti-CD3 is dependent on FOXP3+ Tregs
Tatiana Takiishi, T. van Belle, S. Robert, H. Korf, P. Rottiers, C. Gysemans, C. Mathieu
Leuven, Belgium
W3.04.04 - Genetic variation and positional biases influence rearrangement of lymphocyte receptor genes
Marie J. Kidd, A.M. Collins
Kensington, Australia
58
16.45-18.15
AMBER 5+6
W3.04 - GENETIC REARRANGEMENTS OF
LYMPHOCYTE RECEPTORS
IL3.04.01 - Combinatorial H3K9acS10ph histone modifications in IgH locus S regions target 14-3-3 adaptors and AID to specify antibody class switch DNA
recombination
Paolo Casali, G. Li
Irvine, United States
W3.04.06 - The conservation of immunoglobulin
genes: an evolutionary link between autoreactivity
and innate response against pathogens
André M. Vale, P. Kapoor, T.I. Mahmoud, C. Zemlin,
M. Zemlin, P.D. Burrows, J.F. Kearney, D.E. Briles, A. Nobrega, H.W. Schroeder
Rio de Janeiro, Brazil
W5.06 - REGULATORY T CELLS IN
AUTOIMMUNITY AND ALLERGY
W6.08.05 - Allogenicity of human cardiac stem/progenitor cells orchestrated by programmed death ligand 1 (PD-L1)
L. Lauden, W. Boukouaci, L.R. Borlado, I.P. López,
P. Sepúlveda, R. Tamouza, D. Charron, Reem Al-Daccak
Paris, France
Chairs: Paolo Casali (USA)
Roberto Sitia (ITA)
W3.04.05 - Secondary immunoglobulin heavy chain
rearrangements in IgA cloned mice
Rashmi Kumar, O. Kanagawa, S. Fagarasan, S. Casola
Milan, Italy
Workshops August 25, 2013
W2.09 - MHC AND OTHER
POLYMORPHIC GENES IN HEALTH
AND DISEASE
W1.07.04 - The inhibitory effect of secretory leukocyte protease inhibitor (SLPI) on formation of neutrophil extracellular traps
Katarzyna Zabieglo, A. Wlodarczyk, M. Kapinska-Mrowiecka, A. Dubin, J. Cichy
Krakow, Poland
IL2.09.01 - MHC and other polymorphic genes in
health and disease
Jeffrey A. Frelinger, D. Jaraquemada
Tucson, United States
16.45-18.15
AMBER 7+8
W2.09.01 - Tapasin facilitation of MHC-I separates closely related allomorphs, is strongly influenced by
peptide length and depends on stability
L. Geironson, C. Thuring, M. Harndahl, M. Rasmussen,
S. Buus, G.A. Røder, Kajsa M. Paulsson
Lund, Sweden
16.45-18.15
BROWN 1
Chairs: Jeoffrey A. Frelinger (USA)
Dolores Jaraquemada (ESP)
W2.09.02 - NLRC5 controls basal MHC class I gene expression in an MHC-enhanceosome dependent manner
A. Neerincx, G. Rodriguez, V. Steimle, Thomas Kufer
Köln, Germany
W7.03 - STRUCTURAL BIOLOGY IN
IMMUNOLOGY
Chairs: Mette M. Rosenkilde (DEN)
Stephanie Gras (AUS)
W2.09.04 - Usage of a genome-wide shRNA-based
lentiviral screen and targeted siRNA knockdown to
identify host cell proteins involved in US2- and US11mediated degradation of MHC-I molecules
Daniel C. Chapman, P. Stocki, F. Teusel, D.B. Williams
Toronto, Canada
IL7.03.01 - Structural basis of viral escape in Influenza
Stephanie Gras, S. Valkenburg, C. Guillonneau, L. Hatton,
K. Twist, A. Purcell, P. Doherty, J. Rossjohn, S. Turner,
K. Kedzierska
Clayton, Australia
W2.09.05 - Comparative analysis of DQA1*05/DQB1*02
mRNAs and DQ2 heterodimer expression in relation
to antigen presentation
L. Pisapia, A. Camarca, P. Barba, S. Picascia, G. Del Pozzo,
Carmen Gianfrani
Avellino, Italy
16.45-18.15
BROWN 1
Chairs: William M. Nauseef (USA)
Philip M. Murphy (USA)
W1.07.01 - STIM2 is the essential STIM protein in nonSOCE calcium responses of macrophages in vitro and
in vivo
Georgios Sogkas, S. Syed, E. Rau, D. Stegner, T. Vögtle,
B. Nieswandt, R. Schmidt, E. Gessner
Hannover, Germany
W1.07.02 - Glomerular deposition of myeloperoxidase and NETs in human anti ANCA associated vasculitis correlates with DTH effector cell accumulation
Kim M. O’Sullivan, S.L. Ford, C. Lo, A.R. Kitching,
S.R. Holdsworth
Melbourne, Australia
W1.07.03 - Leishmania inhibits antigen crosspresentation by cleaving VAMP8
N. Moradin, D. Matheoud, M. Desjardins, Albert Descoteaux
Laval, Canada
W7.03.01 - Crystal structure of adenovirus E3-19K
protein bound to HLA-A2 reveals mechanism for
immunomodulation
L. Li, Y. Muzahim, Marlene Bouvier
Chicago, USA
16.45-18.15
BROWN 2
W1.07 - EFFECTORS FUNCTIONS OF
PHAGOCYTES (JOINT WITH SOCIETY OF
LEUKOCYTE BIOLOGY)
W1.07.06 - FAM19A4: a novel cytokine promotes phagocytosis of zymosan but negatively regulates TNF secretion associated with NF-B pathway in
macrophages.
Wenyan Wang, P. Wang, T. Li, X. Wang, W. Yuan,
H. Zhang, Y. Zhang, D. Ma, W. Han
Beijing, China
Discussion
W2.09.03 - TAPBPR uses the same residues as tapasin
to associate with MHC-I
Clemens Hermann, L.M. Strittmatter, L.H. Boyle
Cambridge, United Kingdom
W2.09.06 - Novel HLA-B27-restricted epitopes from
Chlamydia trachomatis suggest a role of molecular
mimicry in reactive arthritis
Carlos Alvarez-Navarro, J. Cragnolini, H. G. Dos Santos,
E. Barnea, A. Admon, A. Morreale, J. López de Castro
Madrid, Spain
W1.07.05 - The role of iRhom2 (rhbdf2) during immune activation
Philipp A. Lang, D.R. McIlwain, D. Häussinger, K. Lang,
P.S. Ohashi, T. Maretzky, P. Darshinee, J. Salmon,
C.P. Blobel, T.W. Mak
Dusseldorf, Germany
W7.03.02 - Structural insight into HLA DQ8 restricted
TCR selection in celiac disease
Jan Petersen, S.E. Broughton, A. Theodossis, A. Thompson, J. van Bergen, Y. Kooy-Winkelaar, R.P. Anderson,
F. Koning, H.H. Reid, J. Rossjohn
Clayton, Australia
W7.03.03 - Divergent T Cell recognition of a lengthy
epitope bound to MHC-I molecule
Yu-Chih Liu
Clayton, Australia
W7.03.04 - The constant region affects antigen binding of antibodies to DNA by altering secondary
structure
Y. Xia, A. Janda, E. Eryilmaz, A. Casadevall, Chaim Putterman
Bronx, USA
W7.03.05 - Structural insight on the recognition of
surface-bound opsonins by the integrin I-domain of
complement receptor 3
Goran Bajic, L. Yatime, T. Vorup-Jensen, G.R. Andersen
Aarhus, Denmark
W7.03.06 - Structural insights into S100 proteins recognition and signal transduction by the Receptor for
Advanced Glycation End-products (RAGE)
Laure Yatime, G.R. Andersen
Aarhus, Denmark
59
Chair: Fiona Powrie (GBR)
Tadamitsu Kishimoto (JPN)
IL-6: new era comes for the treatment of
inflammatory autoimmune diseases
Chair: Andrea Velardi (ITA)
Max D. Cooper (USA)
Evolution of adaptive immunity
Chair: Anne O’Garra (GBR)
Klaus Rajewsky (DEU)
Modeling Epstein-Barr virus pathologies, immune surveillance and human lymphomas in
mice
LL.26 - LUNCHTIME LECTURE
Chair: Vincenzo Barnaba (ITA)
Matthew Albert (FRA)
Chemokine antagonism: an in vivo mechanism
for regulating inflammation during viral infection and tumorigenesis
LL.28 - LUNCHTIME LECTURE
Chair: Olja Finn (USA)
Riccardo Dalla Favera (USA)
Genetic determinants of B cell lymphoma transformation and immune escape
12.30 - 13.15
BROWN 3
LL.24 - LUNCHTIME LECTURE
12.30 - 13.15
SPACE 4
Chair: James Allison (USA)
Giorgio Trinchieri (USA)
The role of the commensal microbiota in regulating inflammation and cancer
12.30 - 13.15
SPACE 1+2
Chair: Marco Colonna (USA)
Diane J. Mathis (USA)
AIRE control of immunological tolerance: new
twists
LL.22 - LUNCHTIME LECTURE
18.30 - 19.15
GOLD ROOM
PS.08 - PERSPECTIVES IN
IMMUNOLOGY
PL.07 - PLENARY LECTURE
12.30 - 13.15
AMBER 3+4
12.30 - 13.15
GOLD ROOM
12.30 - 13.15
BROWN 1+2
12.30 - 13.15
SPACE 3
12.30 - 13.15
AMBER 1+2
60
8.50 - 9.20
SPACE 1+2
PS.07 - PERSPECTIVES IN
IMMUNOLOGY
9.30 - 10.15
GOLD ROOM
8.50 - 9.20
GOLD ROOM
Main Lectures August 26, 2013
LL.23 - LUNCHTIME LECTURE
Chair: Maria Rescigno (ITA)
Fiona Powrie (GBR)
Gut reactions: immune pathways that control
intestinal homeostatis
LL.25 - LUNCHTIME LECTURE
Chair: Dmitry Gabrilovich (USA)
Frederic Geissmann (GBR)
Differentiation and functions of monocytes/macrophages
LL.27 - LUNCHTIME LECTURE
Chair: Attila Mocsai (HUN)
John J. O'Shea (USA)
Helper cell specification: cytokines, transcription
factors and the epigenome
LL.29 - LUNCHTIME LECTURE
Chair: Riccardo Gazzinelli (BRA)
Alan Sher (USA)
IL-1 mediates host resistance to Mycobacterium
tuberculosis through an eicosanoid pathway
PL.08 - PLENARY LECTURE
Chair: William Paul (USA)
Richard A. Flavell (USA)
The inflammasome in health and disease
Parallel Symposia August 26, 2013
Chairs: Anne Ostergaard (CAN)
Wolf H. Fridman (FRA)
Jerome Galon (FRA)
S19.01 From the immune contexture to the
immunoscore in the era of cancer immunotherapy
Gabriel Rabinovich (ARG)
S19.02 Regulatory circuits in autoimmunity and
cancer mediated by lectins and glycans
Mario Colombo (ITA)
S19.03 Neutrophils bridges autoimmunity and
cancer
Vincenzo Bronte (ITA)
S19.04 Molecular regulation of innate immunity in
tumor microenvironment
Dmitry I. Gabrilovich (USA)
S19.05 Myeloid-derived suppressor cells in
regulation of immune responses in cancer
S20 - T AND B CELL SUBSETS
10.20 - 12.25
SPACE 1+2
10.20 - 12.25
GOLD ROOM
S19 - IMMUNE SURVEILLANCE AND
TUMOR IMMUNITY
S22 - COSTIMULATORY AND
INHIBITORY MOLECULES
10.20 - 12.25
BROWN 3
10.20 - 12.25
BROWN 1+2
S21 - NK CELLS
Chairs: Klas Kärre (SWE)
Hans Gustaf Ljunggren (SWE)
Wayne M. Yokoyama (USA)
S21.01 NK cell biology in innate immunity
Miguel Lopez-Botet (ESP)
S21.02 Adaptive reconfiguration of the human
NK-cell compartment in response to
cytomegalovirus
Angela Santoni (ITA)
S21.03 NK cell-mediated immune surveillance of
senescent cells
Eric Vivier (FRA)
S21.04 Natural killer cells, innate lymphoid cells
and Immunity
Bruno Silva-Santos (POR)
S21.05 Molecular mechanisms of differentiation
of gamma-delta T lymphocytes
10.20 - 12.25
SPACE 4
10.20 - 12.25
SPACE 3
Chairs: Susan Swain (USA)
Ronald H. Schwartz (USA)
Yong-Jun Liu (USA)
S22.01 Targeting OX40 to block Treg in Cancer
David Sansom (GBR)
S22.02 The role of CTLA-4 in regulating T cell
responses
Mauro Perretti (GBR)
S22.03 Neutrophil micro particles activates tissue
protective signals
Massimo Locati (ITA)
S22.04 Immune function and mechanism of
action of atypical chemokine receptors
Arlene Sharpe (USA)
S22.05 The multifaceted functions of the PD-1
pathway in controlling T cell activation and
tolerance
S24 - PROTOZOAL, FUNGAL AND
HELMINTH INFECTIONS
S23 - VACCINATION
Chairs: Giuseppe Del Giudice (ITA)
Oliver O. Perez (CUB)
Julie Magarian Blander (USA)
S23.01 Vita-PAMPs: signatures of microbial
viability
Robert L. Coffman (USA)
S23.02 Development of TLR9 agonists as vaccine
adjuvants
Adrian Hill (GBR)
S23.03 Progress with T cell inducing vaccines
against intracellular pathogens
Jorge Kalil (BRA)
S23.04 From molecular immunopathogenesis of
rheumatic fever to the development of a vaccine
against streptococcus pyogenes
Karolina Palucka (USA)
S23.05 Reprogramming the immune environment
in cancer via dendritic cells
Chairs: Tim R. Mosmann (USA)
Kenneth M. Murphy (USA)
William E. Paul (USA)
S20.01 Cytokines and CD4 T cells: dance partners
at the immunology ball
Vijay K. Kuchroo (USA)
S20.02 Transcriptional network controlling Th17
development
Francesco Annunziato (ITA)
S20.03 Epigenetic mechanisms in the regulation
of human Th17 plasticity
Alexander Y. Rudensky (USA)
S20.04 Regulatory T cells in control of
inflammation
Kenneth M. Murphy (USA)
S20.05 Development and function of dendritic
cell subsets
Chairs: Kenji Nakanishi (JPN)
Luigina Romani (ITA)
Rick Maizels (GBR)
S24.01 Impact of helminth parasites on immune
regulation and immunity
Douglas Golenbock (USA)
S24.02 DNA drives innate immune responses in
malaria
Luigina Romani (ITA)
S24.03 The host-mycobioma interactions in health
and diseases
Judith Allen (GBR)
S24.04 Macrophage activation and function
during helminth infection
Mauro Teixeira (BRA)
S24.05 Can we develop anti-inflammatory drugs
for infectious diseases?
61
Sponsored Sessions August 26, 2013
MOVING TRANSLATIONAL IMMUNOLOGY FORWARD THROUGH PUBLIC-PRIVATE
PARTNERSHIP
15.10 - 16.40
SPACE 1
with the contribution of IMI - Innovative Medicine Initiative
Chair: Luciano Adorini (ITA)
Michel Goldman (BLG)
IMI: opportunities and challenges for immunologists
Jeffrey A. Bluestone (USA)
Advancing drug discovery through academic-industry partnerships: the UCSF experience
Marc Feldmann (GBR)
Translating inflammatory understanding towards patient benefit
Paul-Peter Tak (GBR)
Open innovation: a new paradigm for industry-academia collaboration
MODULATION OF IMMUNE SUPPRESSIVE NETWORK TO ENHANCE CANCER
IMMUNOTHERAPY. RECENT ADVANCES AND NEW CHALLENGES
15.10 - 16.40
SPACE 3
with the contribution of Genentech
Chairs: Dmitry Gabrilovich (USA), Vincenzo Bronte (ITA)
Nicholas Restifo (USA)
Ablating/reprogramming aberrant immunity in the tumor microenvironment
Drew Pardoll (USA)
TBD
Francis Balkwill (GBR)
CCR4 and its ligands in renal cancer
TARGETING IL-12/IL-23 IN CHRONIC INFLAMMATORY DISEASES:
THE PSORIATIC SPECTRUM PARADIGM
15.10 - 16.40
SPACE 4
with the contribution of Janssen Pharmaceutica NV
62
Chair: Carlo Selmi (ITA)
Andreas Radbruch (DEU)
The role of IL-12/IL-23 in T Cell differentiation
Emilio Berti (ITA)
Immunopathological correlates in the pathogenesis of psoriatic diseases
Gianpiero Girolomoni (ITA)
Psoriasis as a testing ground for novel biologicals: targeting IL-12/IL-23
Pierluigi Meroni (ITA)
New therapies for psoriatic arthritis: targeting IL-12/IL-23 and beyond
Workshops August 26, 2013
W5.20.10 - Density of tertiary lymphoid structures
predicts T cell infiltration with coordinated Th1 polarization and cytotoxic effectors functions in human
lung cancer
Jérémy Goc, L. de Chaisemartin, A. Lupo, D. Damotte,
P. Validire, D. Vo-Bourgais, P. Devi, W. Fridman, C. SautèsFridman, M. Dieu-Nosjean
Paris, France
W5.20 - TUMOR IMMUNITY AND
IMMUNOSURVEILLANCE
Chairs: Ron Apte (ISR)
Shubhda Chiplunkar (IND)
IL5.20.02 - Notch regulates anti tumor functions of
gamma delta T cells in oral cancer
Shubhada Chiplunkar, D. Gogoi, D. Chaukar, A. D’Cruz
Kharghar, Navi Mumbai, India
W5.20.01 - CD70 reverse signalling on NK cells enhances anti-tumoral immune response
Mohamad Al Sayed, C. Riether, C. Schürch, A. Ochsenbein
Bern, Switzerland
15.10-18.15
GOLD ROOM
IL5.20.01 - IL-1 is a major inflammatory cytokine that
mediates the angiogenic switch in tumor invasiveness
Ron N. Apte, Y. Carmi, S. Dotan, I. Kaplanov, Z. Shavshkevitz, C.A. Dinarello, E. Voronov
Beer Sheva, Israel
W1.09 - DENDRITIC CELL
DIFFERENTIATION AND FUNCTION
W5.20.04 - MicroRNA-9 regulates maturation and
function of myeloid-derived suppressor cells by modulating Runx1
Jie Tian, Y. Zhang, X. Tian, K. Rui, X. Tang, S. Wang
Zhenjiang, China
Chairs: Guido Ferlazzo (ITA)
Pamela Ohashi (CAN)
IL1.09.01 - Dendritic cells identified in the human
system
Guido Ferlazzo
Messina, Italy
W5.20.05 - Neuropilin-1 guides regulatory T cells into
tumor tissues resulting in impaired anti-tumor immunity
Wiebke Hansen, M. Hutzler, I. Helfrich, J. Buer
Essen, Germany
W5.20.08 - Active STAT5 imprints a T-Bet-dependent
Tc-1 program in CD8 T cells inducing efficient regression of autochthonous melanoma
M. Grange, G. Verdeil, A. Schmitt-Verhulst,
Nathalie Auphan-Anezin
Marseille, France
W5.20.09 - T cells from DNAM-1 deficient mice display
polarity defects that impair anti-tumour immunity
Jane Oliaro, K. Ramsbottom, S. Russell, M. Smyth
Melbourne, Australia
IL1.09.02 - Molecular regulators of DC function
Pamela S. Ohashi, E.F. Lind, D. Johnson, D. Dissanayake
Toronto, Canada
15.10-18.15
BROWN 3
15.10-18.15
GOLD ROOM
W5.20.14 - Evaluating parameters that influence
T cell responses to tumor antigens: A role for B7-H4
Ramtin Rahbar, A. Lin, M. Ghazarian, T. Mak, P. Ohashi
Toronto, Canada
W5.20.03 - Predictive clinical significance of tumor infiltrating neutrophils in patients with colorectal cancer
Maria Rosaria R. Galdiero, F. Grizzi, G. Di Caro, L. Laghi,
C. Garlanda, A. Mantovani, S. Jaillon
Milan, Italy
W5.20.07 - Complement dependent immunosurveillance in Her-2/neu autochtonous carcinomas arising
in BALB-neuT transgenic mice
Silvio Bandini, C. Curcio, M. Macagno, M. Iezzi, F. Cavallo
Torino, Italy
W5.20.12 - The BCR regulates Burkitt lymphoma survival and proliferation through the modulation of
GSK3 activity
Gabriele Varano, S. Raffel, F. Zanardi, K. Rajewsky,
S. Casola
Milan, Italy
W5.20.13 - Inhibiting the development of immunosuppressive Gr-1+ dendritic cells in tumors by blokking TLR2 enhances immunotherapy
Michael Tang
Toronto, Canada
W5.20.02 - BRAF inhibitor impacts on melanoma cell
immunogenicity
Emmanuelle Fourmentraux-Neves, M. Messaoudene,
C. Nicolaizeau, M. Avril, K. Belkhiria, A. Savina, A. Caignard
Paris, France
W5.20.06 - A novel self-lipid antigen targets human
T cells against CD1c+ leukemias
Claudia de Lalla, M. Lepore, G. Ramanjaneyulu,
D. Montagna, F. Locatelli, F. Ciceri, L. Mori, P. Dellabona,
G. De Libero, G. Casorati
Milan, Italy
W5.20.11 - Galectin-3 is involved in the immunosuppressive activity of prostate cancer stem cells
Chiara Svetlana Brambillasca, E. Jachetti, M. Grioni,
S. Mazzoleni, M. Freschi, R. Galli, M. Bellone
Milan, Italy
W1.09.01 - Defining dendritic cells by ontogeny
Barbara Schraml, J. van Blijswijk, S. Zelenay, P. Whitney,
A. Filby, N. Rogers, C. Reis e Sousa
London, United Kingdom
W1.09.02 - Lymphatic endothelium forms integrin-engaging 3D structures during DC transit across inflamed lymphatic vessels
Álvaro Teijeira, S. Garasa, R. Pelaez, C. Aubá, C. Alfaro,
R. Magda, S. Vallituti, R. Ana, M. Ignacio
Pamplona, Spain
W1.09.03 - MyD88 signalling drives steady-state intestinal CD103+ DC migration to draining mesenteric
lymph nodes
Karin Hägerbrand, B. Johansson-Lindbom, W. Agace
Lund, Sweden
W1.09.04 - IL-27 in human secondary lymphoid organs attracts myeloid DC and impairs their HLA class
I-restricted antigen processing and presentation
Fabio Morandi, E. Di Carlo, S. Ferrone, V. Pistoia, I. Airoldi
Genoa, Italy
63
Workshops August 26, 2013
W4.08 - IMMUNITY TO PROTOZOAN
PARASITE INFECTION
15.10-18.15
BROWN 3
W1.09.05 - The kindlin-3-beta2 integrin interaction
controls DC activation and Th1/Th2 priming
Vicky L. Morrison, M. MacPherson, K. Grzes, P. Cook,
C. Gawden-Bone, A. Prescott, A.S. MacDonald,
S.C. Fagerholm
Dundee, United Kingdom
Chairs: Franck Brombacher (ZAF)
Nick W. Lukacs (USA)
W1.09.07 - Chronic hypoxia reprograms human immature DCs by inducing a proinflammatory phenotype and TREM-1 expression
Daniele Pierobon, M.C. Bosco, F. Blengio, F. Raggi,
A. Eva, T. Musso, F. Novelli, P. Cappello, L. Varesio,
M. Giovarelli
Turin, Italy
W4.08.02 - Recognition of Leishmania parasites by
the macrophage-inducible C-type lectin Mincle subverts adaptive immunity and promotes susceptibility
to infection
Salvador Iborra, H. Izquierdo, N. Enamorado, R. Conde,
R. Reguera, M. Soto, D. Sancho
Madrid, Spain
W1.09.08 - The mitochondrial protein, TCAIM, abolishes T cell priming of DCs by inhibiting TLR-induced
IL-2 expression
Simone Vogel, S. Schlickeiser, I. Panov, M. Schröder,
M. Lutz, K. Vogt, G. Grütz, B. Sawitzki
Berlin, Germany
W4.08.03 - Marginal zone B-cells suppress antigenspecific T-cell responses during experimental L. donovani infection
R. Bankoti, K. Gupta, Simona Stager
Laval, Canada
W1.09.09 - PAF induces regulatory DCs through two
independent mechanisms: amplification of
COX2/PGE2 loop and induction of IL10
Marianna M. Koga, F.J.O. Rios, B. Bizzarro, A. Sá-Nunes,
S. Jancar
Sao Paulo, Brazil
15.10-16.40
SPACE 2
W1.09.06 - Deletion of IL-4 receptor alpha on DCs renders mice hypersusceptible to Leishmania major
infection
Frank Brombacher
Cape Town, South Africa
W4.08.01 - Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to
Leishmania major infection
Ramona Hurdayal, N.E. Nieuwenhuizen,
M. Revaz-Breton, L. Smith, J.C. Hoving, S.P. Parihar,
B. Reizis, F. Brombacher
Cape Town, South Africa
W1.09.10 - Glucocorticoid-Induced Leucine Zipper expression in DCs controls Treg induction in vivo
Joseph Calmette, T. Tran, S. Karaki, M. Ellouze,
M. Pallardy, F. Bachelerie, R. Krzysiek, D. Emilie,
G. Schlecht-Louf, V. Godot
Clamart, France
W4.08.05 - Protective CD8+ T effector memory cells
elicited by heterologous prime-boost vaccination expand and re-circulate after an infectious challenge
with Trypanosoma cruzi
J.R. Vasconcelos, Mariana Ribeiro Dominguez,
R. Lemos, L.I. Santos, F. Virgilio, A.V. Machado, O. BrunaRomero, R.T. Gazzinelli, M.M. Rodrigues
São Paulo, Brazil
W1.09.11 - The inhibitory NK receptor Ly49Q protects
plasmacytoid dendritic cells from TLR9-triggering cell
death by assuring lysosomal integrity
Noriko Toyama-Sorimachi, M. Tanaka, T. Kobayashi,
A.P. Makrigiannis, K. Inaba
Tokyo, Japan
W4.08.06 - Immunological mechanisms of co-infection of schistosomiasis and malaria in a primate
model
Ruth K. Nyakundi, J. Maamun, M. Akinyi, O. Nyamongo,
I. Mulei, H. Ozwara, I.O. Farah, I. Malhotra, C.L. King,
T. Kariuki
Nairobi, Kenya
W1.09.12 - Membrane transfer from tumor cells generates plasmacytoid dendritic cells cross-dressed
with exogenous antigens
Irene Bonaccorsi, B. Morandi, G. Costa, D. Oliveri,
R. Conte, G. Pezzino, M. Mingari, G. Ferlazzo
Messina, Italy
W1.09.14 - Dendritic cells partake in regulation of
ovarian physiology
Adva Cohen-Fredarow, A. Tadmor, T. Raz, N. Meterani,
M. Neemam, G. Mor, N. Dekel
Rehovot, Israel
64
W4.07 - IMMUNITY TO HELMINTH
INFECTION
Chairs: Shigeo Koyasu (JPN)
Anne La Flamme (NZL)
15.10-16.40
AMBER 1+2
W1.09.13 - Myeloid cells in the islets of Langerhans
are key players in presentation of islet antigens and
trophic function: identification of their phenotype
and ontogeny
Boris Calderon, E.R. Unanue
St. Louis, USA
W4.08.04 - Cellular immune polarization to a cell phenotype Th-1 and T-Reg is induced after the treatment
of human dendritic cells infected by Leishmania with
the compound 11,19-dihydroxy-7-acetoxy-7-deoxoichangin
Gabriela Delgado, D. Granados-Falla, C. Coy-Barrera,
L. Cuca
Bogota, Colombia
IL4.07.01 - Driving disease outcome in schistosomiasis: correlating antibody to disease severity
Anne C. La Flamme, B. Manivannan, J. Jaurigue,
T.W. Jordan, W.E. Secor, B. Doughty
Wellington, New Zealand
W4.07.01 - CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis
Holly E. Ponichtera, R. Raychowdhury, M.G. Shainheit,
J.M. Russo, B.M. Larkin, D.B. Salantes, S.C. Bunnell,
N. Hacohen, M.J. Stadecker
Boston, USA
W4.07.02 - Immunological changes in epidermal keratinocytes following infection with schistosome cercariae
Claire D. Bourke, A.P. Mountford
York, United Kingdom
Chairs: Daniela Frasca (USA)
Scheherazade Sadegh-Nasseri (USA)
W4.07.04 - Innate and adaptive IL-9 orchestrate type
2 immunity
Paula Licona-Limón, J. Henao-Mejía, N. Gagliani,
I. Licona-Limón, D.R. Herbert, R.A. Flavell
New Haven, USA
IL2.05.01 - Genetic Regulation of Longevity in Memory CD4 T cells in Aged mice
Scheherazade Sadegh-Nasseri, S. Khoruzhenko,
N. Song, S. Sonder
Baltimore, United States
W4.07.05 - Mechanisms of the lymphocyte hypo-responsiveness after repeated exposure of the skin to
Schistosoma mansoni cercariae
Catriona T. Prendergast, P. Cook, A. Mountford
York, United Kingdom
W4.07.06 - IL-10 secreting, type 1 regulatory T cells
and naturally occurring regulatory T cells differently
modulate IgG secretion by B cells in human hypo-responsive onchocerciasis
Tomabu Adjobimey, C. von Horn, J. Satoguina,
J. Oldenburg, L. Layland, A. Hoerauf
Bonn, Germany
W6.09 - VACCINE ADJUVANTS
Chairs: Paola Parronchi (ITA)
Ali Harandi (SWE)
W2.05.01 - Characterization of the role of distinct
plasma cell-free DNA (cf-DNA) species in age-associated inflammation and frailty
Juulia Jylhävä
Tampere, Finland
IL6.09.01 - Vaccine adjuvants for mucosal immunity:
recent progress and future challenges
Ali Harandi
Gothenburg, Sweden
W2.05.06 - Human B cell response to the influenza
vaccine is predicted by AID and decreased by inflammaging
Bonnie B. Blomberg, A. Diaz, M. Romero, A. Landin,
D. Frasca
Miami, USA
W6.09.02 - Using immunopotentiating capacity of flagellin for sublingual immunotherapy
Natalia Muñoz-Wolf, A. Rial, J.M. Saavedra, J. Tabareau,
D. Fougeron, J.M. Marqués, J. Sirard, J.A. Chabalgoity
Montevideo, Uruguay
W6.09.03 - A Dectin-1-assisted APC-targeting TLR9agonist as an adjuvant
Kouji Kobiyama, K.J. Ishii
Ibaraki, Japan
W7.05 - EVOLUTION OF THE IMMUNE
SYSTEM AND COMPARATIVE
IMMUNOLOGY
15.10-16.40
AMBER 7+8
15.10-16.40
AMBER 3+4
W2.05.03 - Assessing human TCR CDR3 repertoire by
a RACE-PCR-sequencing method
H. Li, T. Hiroi, Y. Zhang, G. Chen, S. De, E.J. Metter,
W.H. Wood III, K.G. Becker, Nan-ping P. Wenig
Baltimore, USA
W2.05.05 - Memory immune response to booster vaccination in old age depends on adequate priming
earlier in life
Birgit Weinberger, C. Neuner, M. Schirmer, R. Mateucci
Gothe, B. Grubeck-Loebenstein
Innsbruck, Austria
W6.09.01 - Novel adjuvants for DNA vaccines
Tamsin Gargett, T. Garrod, B. Grubor-Bauk, W. Yu,
D. Miller, L. Major, S. Wesselingh, A. Suhrbier, E. Gowans
Adelaide, Australia
W6.09.05 - Antigen trafficking within lymphoid organs and humoral immune response: The effect of
MF59 adjuvant
Rocco Cantisani, A. Pezzicoli, C. Malzone, A. Seubert,
F. Giusti, U. D’Oro, E. De Gregorio, M. Carroll, D. Piccioli
Siena, Italy
W2.05.02 - Senescence associated cells in human
CD8+ T-lymphocytes
Oscar O. Onyema, L.N. Forti, R. Njemini, I. Bautmans,
J. Aerts, M. De Waele, T. Mets
Brussel, Belgium
W2.05.04 - Memory B cell repertoire changes with age
Deborah K. Dunn-Walters.
London, United Kingdom
IL6.09.02 - Perspectives in vaccine adjuvants
Paola Parronchi, L. Filì, E. Cardilicchia
Firenze, Italy
W6.09.04 - Adjuvants are the future of vaccine formulation. The case of Finlay adjuvants
Oliver Pérez, M. Lastre, B. Romeu, O. Cabrera, M. Cuello,
E. González, A. Batista-Duharte, A. Labrada, W. Ramírez,
R. Nicado
Havana, Cuba
W6.09.06 - SBA-15 nanostructured silica adjuvant enhances immune responsiveness and modulates sensibility to bacterial toxins
Karina Scaramuzzi, G.D. Tanaka, M. Tino De Franco,
A.G. Trezena, O.A. Sant Anna
Sao Paulo, Brazil
W2.05 - IMMUNE RESPONSES IN
AGING
15.10-16.40
AMBER 5+6
15.10-16.40
AMBER 1+2
W4.07.03 - Basophils contribute to the Th2-type protective immunity against re-infection with intestinal
helminths
Kazushige Obata-Ninomiya, H. Tsutsui, K. Ishiwata,
N. Watanabe, H. Kanuka, H. Karasuyama
Tokyo, Japan
15.10-16.40
AMBER 3+4
Workshops August 26, 2013
Chairs: Michael JH Ratcliffe (CAN)
Loriano Ballarin (ITA)
IL7.05.01 - Antigen Mediated Positive and Negative
Selection of Developing Chicken B Cells
Michael J.H. Ratcliffe, D. Davani
Toronto, Canada
IL7.05.02 - Phenoloxidases and cytotoxicity in ascidians: an overview
Loriano Ballarin, N. Franchi, F. Schiavon, S.C.E. Tosatto
Padova, Italy
65
Workshops August 26, 2013
15.10-16.40
AMBER 7+8
W7.05.02 - Atlantic cod displays an unusual TLR repertoire: A Gadidae-specific feature?
Monica H. Solbakken, M. Malmstroem, O. Toerresen,
K.S. Jakobsen, S. Jentoft
Oslo, Norway
W7.05.03 - Evolution of antigen recognition by
V9V2 T cells
Mohindar Murugesh Karunakaran, L. Starick, L. Walter,
T. Goebel, T. Herrmann
Wuerzburg, Germany
15.10-16.40
BROWN 1
W7.05.01 - Generation of B lymphocytes and immunoglobulin diversity in Bos taurus
J. Liljavirta, A. Ekman, Mikael Niku, T. Pessa-Morikawa,
A. Iivanainen
Helsinki, Finland
W5.18 - INFLAMMATORY BOWEL
DISEASES
Chairs: Silvio Danese (ITA)
Fabio Cominelli (USA)
W7.05.05 - Phenoloxidases and cytotoxicity in ascidians: An overview
Ballarin Loriano, N. Franchi, F. Schiavon, S.C.E. Tosatto
Padua, Italy
W5.18.01 - Depletion of regulatory T cells improves
anti-tumour immunity in colitis-associated colon cancer
E. Pastille, K. Schumann, D. Fleissner, W. Hansen,
T. Sparwasser, J. Buer, Astrid M. Westendorf
Essen, Germany
W7.05.06 - The secondary structure of the pre-mRNA
encoding the antarctic fish Ig chain drives its atypical splicing pattern
Stefano Giacomelli, S. Varriale, U. Oreste, M. Coscia
Naples, Italy
W5.18.02 - RIP3 promotes injury-induced cytokine expression and tissue repair
Kenta Moriwaki, F.K. Chan
Worcester, USA
W3.06 - COSTIMULATION
15.10-16.40
BROWN 1
W3.06.01 - Mechanical insights into the functional
impacts of interactions between antigen-presenting
cells and T cells
T.S. Lim, A. Mortellaro, C. Lim, G. J. Hämmerling, Mariana
Paola Ricciardi-Castagnoli
Singapore, Singapore
W3.06.02 - Basilic, a lymphoid-specific protein essential for CD28 costimulation and regulatory T cell development
Marie Malissen, L. Yinming, M. Cucchetti, R. Roncagalli,
T. Yokosuka, T. Saito, C. Wuelfing, B. Malissen
Marseille, France
W3.06.03 - Human memory T cell subsets require distinct costimulatory signals to efficiently expand ex
vivo
Valentina Volpin, N. Cieri, C. Bonini
Milan, Italy
66
15.10-16.40
BROWN 2
Chairs: Loretta Tuosto (ITA)
Matthias Von Herrath (USA)
IL3.06.02 - Viruses and type 1 diabetes - the good and
the bad
Matthias G. Von Herrath
La Jolla and Seattle, United States
W3.06.05 - PD-1 controls effectors but not the generation or function of natural or induced regulatory T
cells
Kristofor K. Ellestad, G. Thangavelu, C.L. Ewen,
C.C. Anderson
Edmonton, Canada
W3.06.06 - Immunogenic, but not steady-state, antigen presentation permits Treg control of CD8+ T cell
effector differentiation through IL-2 modulation
Raymond J. Steptoe, A. McNally, R. Thomas
Woolloongabba, Australia
W7.05.04 - Drosophila Helical factor (Hf) and helical
cytokine evolution: From in silico approaches to
functional evidence
Davide Malagoli
Modena, Italy
IL3.06.01 - Autonomous CD28 signalling pathways in
the regulation of T lymphocyte survival and pro-inflammatory functions
Loretta Tuosto
Rome, Italy
W3.06.04 - Differential usage of costimulatory
/coinhhibitory pathways by antigen-specific CD8+ T
cells in patients with chronic hepatitis C
Solomon Owusu Sekyere, P. Suneetha, V. Schlaphoff,
M. Manns, M. Cornberg, H. Wedemeyer
Hannover, Germany
W5.18.03 - Induction of IL-33 is dependent on the gut
microflora and is essential for EOS activation/migration and Th2 immune responses in the pathogenesis
of experimental IBD
Carlo De Salvo, X. Wang, S. Chowdhry, D. Corridoni,
F. Cominelli, J.J. Lee, W. Xin, T.T. Pizarro
Cleveland, USA
W5.18.04 - Targeting IL-23/TH17 axis to suppress intestinal inflammation in murine spontaneous colitis
induced by an epithelial defect
Ran Wang, S. Hasnain, H. Tong, I. Das, A. Chen, T. Florin,
R. Eri, M. McGuckin
Brisbane, Australia
W5.18.05 - The p50 NF-B subunit is a key orchestrator of cancer-related intestinal inflammation
Chiara Porta, L. Carraro, M.G. Totaro, M. Rimoldi,
F. Pasqualini, M. Nebuloni, A. Sica
Novara, Italy
W5.18.06 - Novel HLA-DR transgenic mice that spontaneously develop colitis with serious defects in lymphoid organs
Atsushi Irie, J. Yatsuda, Y. Michibata, T. Kubo, T. Imamura,
N. Takeda, I. Shibuya, S. Sogo, Y. Nishimura
Kumamoto, Japan
Workshops August 26, 2013
W2.08 - ANTIGEN RECEPTOR
SIGNALING
W4.09.02 - Hemozoin induces lung inflammation and
correlates with malaria-associated acute respiratory
distress syndrome
Katrien Deroost, A. Tyberghein, N. Lays, E. Schwarzer,
M. Komuta, M. Prato, P. Arese, D. Daelemans,
G. Opdenakker, P.E. Van den Stehen
Leuven, Belgium
Chairs: Yvonne Rosenstein (MEX)
Alberto Amadori (ITA)
16.45-18.15
SPACE 1
W2.08.01 - Antigen-specific TCR-pMHC catch bond
enables force to trigger T cell signalling
Cheng Zhu, B. Liu, W. Chen, B. Evavold
Atlanta, USA
W2.08.02 - Regulation of the Ras-Erk cascade during
T-cell activation.
Mateusz Poltorak, B. Schraven, L. Simeoni
Magdeburg, Germany
16.45-18.15
SPACE 2
IL2.08.01 - Novel assignments for the CD43 molecule
M.E. Bravo-Adame, M. Sandoval-Hernández, N.A. Fierro,
E. Pérez-Rueda, J. Carneiro, R. Vera, B. Barkla, M.E. CruzMunoz, Yvonne Rosenstein
Cuernavaca, Mexico
W2.08.03 - Kidins220/ARMS associates with B-Raf
and the TCR promoting sustained Erk signalling in T
cells
Gina J. Fiala, S. Deswal, A. Meyer, A.E. Eisenhardt,
L.C. Schmitt, M. Salek, T. Brummer, O. Acuto, S. Minguet,
W.W.A. Schamel
Freiburg, Germany
W4.09.06 - Progress towards a broadly neutralizing
vaccine against the asexual blood-stage of Plasmodium falciparum
Alexander D. Douglas, A.R. Williams, J.J. Illingworth,
K. Hjerrild, S.J. Draper
Oxford, United Kingdom
W2.08.05 - Lysophosphatidic acid receptor 5 inhibits
B cell antigen receptor signalling and antibody
response
Raul M. Torres, J. Hu, S. Oda, A. Al-Shami, Y. Fujiwara,
G. Tigyi, T. Oravecz, R. Pelanda
Denver, USA
W4.06 - IMMUNITY TO FUNGAL
INFECTION
Chairs: Vera Calich (BRA)
Betty Wu-Hsieh (TWN)
W2.08.06 - Negative regulation of chemokine receptor signalling and B cell chemotaxis by p66Shc
Nagaja Capitani, L. Patrussi, E. Cannizzaro, F. Finetti,
O. Lucherini, P. Pelicci, C.T. Baldari
Siena, Italy
IL4.09.01 - Malaria and its delectable mammalian
organ - the liver
Urszula Krzych, A.V. Pichugin, S.N. Zarling, O. Jobe
Silver Spring, United States
IL4.09.02 - Pathogenetic role of hemozoin (malaria
pigment) in severe P. falciparum malaria
N. Basilico, Y. Corbett, S. Parapini, S. D’Alessandro,
D.P. Ilboudo, D. Scaccabarozzi, Donatella Taramelli
Milano, Italy
W4.09.01 - Antibodies to Plasmodium falciparum merozoite surface protein and neutrophil respiratory
burst activity are associated with clinical outcome in
severe urban malaria
Babacar Mbengue
Dakar, Senegal
IL4.06.01 - The crucial role of indoleamine 2,3-dioxygenase (IDO) in the tolerogenic and immunogenic
mechanisms against Paracoccidioides brasiliensis infection
Vera L.G. Calich, E.F. Araújo
São Paulo, Brazil
16.45-18.15
AMBER 1+2
16.45-18.15
SPACE 2
Chairs: Ursula Krzych (USA)
Donatella Taramelli (ITA)
W4.09.04 - Apolipoprotein E is critical for the development of cerebral malaria
Fikregabrail A. Kassa, M. Olivier
Montreal, Canada
W4.09.05 - Validation of novel antigenic targets identified by whole-genome screening for next-generation malaria vaccines
Sophie Schussek, A. Trieu, S.H. Apte, D.L. Doolan
Brisbane, Australia
W2.08.04 - Dual-specificity phosphatase 14 negatively regulates TAK1 signalling and immune responses
Chia-Yu Yang, T. Tan
Miaoli County, Taiwan
W4.09 - MALARIA PATHOGENESIS AND
VACCINES
W4.09.03 - IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1
cells during malaria infection by repressing IL-12 dependent signals
Ana Villegas-Mendez, B.J. de Souza, S. Lavelle,
E.G. Findlay, T.N. Shaw, N. van Rooijen, C.J. Saris,
C.A. Hunter, E.M. Riley, K.N. Couper
Manchester, United Kingdom
IL4.06.02 - Dectin-2 and NLRP3 Are Involved in Inflammasome Activation in Dendritic Cell Response to
Histoplamsa Stimulation
Betty Wu-Hsieh, T. Chang
Taipei, Taiwan
W4.06.01 - IL-17 regulates fungal immunity by controlling the functional competence of NK cells
Eva Bär, S. LeibundGut-Landmann
Zürich, Switzerland
W4.06.02 - LAB/NTAL facilitates fungal/PAMP-induced IL-12 production and Th1 responses by repressing
-catenin activation in dendritic cells
Selinda J. Orr, A.R. Burg, L. Quigley, G.W. Jones,
J.W. Ford, G.M. O’Connor, P.R. Taylor, G. Trinchieri,
D.W. McVicar
Cardiff, United Kingdom
67
16.45-18.15
AMBER 1+2
W4.06.03 - IL-33-dependent signalling regulates innate and adaptive immunity following pulmonary
Cryptococcus neoformans infection
Adam Flaczyk, C.U. Duerr, M. Shourian, E.I. Lafferty,
J.H. Fritz, S.T. Qureshi
Montreal, Canada
W4.06.04 - Pathogen recognition by the long pentraxin PTX3: fine tuning by protein glycosylation
Antonio Inforzato, M. Sironi, S. Valentino, B. Bottazzi,
A. Mantovani
Milan, Italy
16.45-18.15
AMBER 3+4
Workshops August 26, 2013
W4.06.05 - Enhancement of innate immune response
to Penicillium marneffei conidia by cooperative interaction of pattern recogntion receptors
Sansanee C. Chaiyaroj, N. Ngaosuwannakul,
M. Thongpan, Y. Srinoulprasert, P. Chansrichavala
Bangkok, Thailand
Chairs: Sandra Blois (DEU)
Gerard Chaouat (FRA)
IL5.19.01 - Galectins in pregnancy: the bitter side of
sweet
Sandra M. Blois
Berlin, Germany
W5.19.01 - Fetal loss induced by depletion of innate
33D1+ dendritic cell subset in mice
Yasuyuki Negishi, A. Wakabayashi, M. Shimizu,
T. Matsuhashi, T. Ichikawa, T. Takeshita, H. Takahashi
Tokyo, Japan
W6.10 - MUCOSAL VACCINES
W5.19.03 - Placental cells promote a tolerant fetal environment by inducing homeostatic macrophages
and regulatory T cells
Judit Svensson Arvelund, R.B. Mehta, E. Mirrasekhian,
S. Freland, G. Berg, M.C. Jenmalm, J. Ernerudh
Linköping, Sweden
W6.10.02 - Development a novel mucosal vaccine targeted to GP2 on Peyer’s patch M cells
Hideaki Shima, T. Watanabe, O. Ohara, H. Ohno
Yokohama, Japan
W5.19.05 - The atypical chemokine receptor D6 is expressed by trophoblasts and plays roles in placental
formation and chemokine scavenging
Fiona M. Menzies, P.J. Teoh, C. Waddell, S.M. Nelson,
R.J.B. Nibbs
Paisley, United Kingdom
W6.10.03 - Molecular uniformed rice-based oral cholera toxin B subunit vaccine without plant-associated
sugar modification induces toxin-specific neutralizing
immunity in mice and macaques
Yoshikazu Yuki, M. Mejima, S. Kurokawa, T. Hiroiwa,
Y. Takahashi, Y. Katakai, M. Kuroda, N. Takeyama,
K. Kashima, H. Kiyono
Tokyo, Japan
W5.19.06 - Genital Chlamydia trachomatis infection
induced microRNA profiles may contribute to associated inflammation and reproductive sequelae
Bernard P. Arulanandam, R. Gupta, T. Arkatkar, J. Yu,
S. Wali, J.P. Chambers, M. Guentzel
San Antonio, USA
W6.10.05 - Cross-strain protective immunity elicited
by a live attenuated nasal spray influenza vaccine
16.45-18.15
AMBER 7+8
16.45-18.15
AMBER 3+4
W5.19.02 - HLA-G expressing DC-10 and CD4+ T cells
accumulate in human decidua in the first trimester of
pregnancy
Giada Amodio, A. Mugione, A. Sanchez, P. Viganò,
M. Candiani, E. Somigliana, M. Roncarolo,
P. Panina-Bordignon, S. Gregori
Milan, Italy
W5.19.04 - Demonstration of the deleterious impact
of foeto-maternal MHC identity on the success of
pregnancy in a macaque model
A. Aarnink, E.T. Mee, N. Savy, N.J. Rose, Antoine Blancher
Toulouse, France
W6.10.01 - Microbe-dependent proliferating IgA-producing plasma cells mediate early-phase robust intestinal IgA responses in mice
Jun Kunisawa, E. Hashimoto, I. Ishikawa, Y. Suzuki,
R. Sumiya, S. Shikata, H. Kiyono
Tokyo, Japan
W6.10.04 - Advantage of a new intra-cheek immunization route for therapeutic vaccines of human papillomavirus-associated head and neck cancers
Rodney Macedo, G. Lescaille, V. Mateo, C. Baillou,
B. Bellier, F.M. Lemoine
Paris, France
68
16.45-18.15
AMBER 5+6
Chairs: Mi-Na Kweon (KOR)
Charani Ranasinghe (AUS)
IL6.10.02 - Novel HIV-1 IL-13R2 adjuvanted vaccines:
High avidity mucosal and systemic CD8 T cells with
greater protective immunity
Charani Ranasinghe, S. Trivedi, D.K. Wijesundara,
R.J. Jackson
Canberra, Australia
W6.10.06 - Safety evaluation of Neuraminidase as a
targeting substance of allergen-loaded microparticles
for oral food allergy treatment
Cornelia Schultz, S.C. Diesner, X. Wang, F. Roth-Walter,
T. Eiwegger, Z. Szépfalusi, I. Pali-Schöll, E. Jensen-Jarolim,
F. Gabor, E. Untersmayr
Vienna, Austria
W5.19 - REPRODUCTIVE
IMMUNOLOGY
W4.06.06 - Are lipid rafts involved in the immune response to Candida albicans?
R. Teloni, A. Torosantucci, S. Becattini, F. Sallusto, R. Nisini,
Maria C. Gagliardi
Rome, Italy
IL6.10.01 - Acute epithelial death plays a role in intrinsic defense against enteric bacteria
Mi-Na Kweon
Seoul, Republic of Korea
after prime-boost immunization
J. Li, M.T. Arévalo, Y. Chen, Mingtao Zeng
El Paso, USA
W7.07 - VETERINARY IMMUNOLOGY
Chairs: Massimo Amadori (ITA)
Wayne Hein (AUS)
IL7.07.01 - In vitro evaluation of the anti-inflammatory control actions of interferon-alpha in swine
E. Razzuoli, R. Villa, Massimo Amadori
Brescia, Italy
W7.07.01 - A novel multi-stage subunit vaccine
against paratuberculosis induces significant immunity and reduces bacterial burden in tissues
Aneesh Thakur, C. Aagaard, U. Riber, K. Skovgaard, P.
Andersen, G. Jungersen
Copenhagen, Denmark
W7.07.03 - Novel peptide-MHC tetramers to characterize the specificity of the CD8+ T cell response
against Theileria parva
Nicholas Svitek, R. Saya, L. Steinaa, E. Awino, A.M. Hansen, M. Nielsen, S. Buus, V. Nene
Nairobi, Kenya
W2.12.06 - Molecular profiling of LFA-1 signalling in
T cells identifies novel genomic signatures implicated
in Th1, Th17 and iTreg polarization
N.K. Verma, E. Dempsey, S.P. Barry, A. Davies,
Aideen Long, P.G. Fallon, Y. Volkov, D. Kelleher
Dublin, Ireland
Chairs: Agnes Lehuen (FRA)
Tanya J. Webb (USA)
IL1.04.01 - Regulatory role of iNKT cells, from viral infection to type 1 diabetes
Agnes Lehuen, L. Ghazarian, Y. Simoni, L. Beaudoin,
J. Diana
Paris, France
W7.07.04 - Dendritic cell tracking in pigs
Elisa Crisci, L. Fraile, R. Novellas, Y. Espada, R. Cabezon,
J. Martínez, D. Benitez, M. Montoya.
Bellaterra, Spain
W7.07.05 - Development an ELISA method to diagnose infected poultries
T. Emami, Rasol Madani, F. Golchinfar
Alborz, Islamic Republic of Iran
IL1.04.02 - Therapeutic potential of NKT cell adjuvantbased therapies for the treatment of B-cell lymphoma
Tonya J. Webb, J. Li, W. Sun, P.B. Subrahmanyam,
C. Page, M. Frieman, Q. Chen, A.S. Kimball
Baltimore, United States
W7.07.06 - A role of myeloid precursor cells (MDSCs),
p-STAT 3 and lymphocyte Treg in development of immunosuppression in dogs with skin and mammary
cancer
Joanna M. Mucha, T. Motyl, K. Majchrzak, M. Król
Warsaw, Poland
W1.04.01 - Development of MAIT cells in the human
fetus
Edwin Leeansyah, L. Loh, D.F. Nixon, J.K. Sandberg
Stockholm, Sweden
W2.12 - SIGNALING IN IMMUNE CELLS
W1.04.02 - miRNA regulation of iNKT cell development
Maya Fedeli, V. Maselli, M. Riba, G. Rossetti, M. Pagani,
S. Abrignani, A. Liston, E. Stupka, P. Dellabona,
G. Casorati
Milan, Italy
Chairs: Christopher E. Rudd (GBR)
Tse-Hua Tan (TWN)
IL2.12.01 - T-cell signaling via adaptor regulation of
the nuclear pore complex (NPC)
Christopher E. Rudd
Cambridge, United Kingdom
W2.12.01 - GRAIL targets CDC37 to maintain CD4 T
cell unresponsiveness
Chan C. Whiting, D. Gomez-Martin, J.M. Schartner, L. Su,
C. Fathman
Palo alto, USA
16.45-18.15
BROWN 1
W2.12.05 - IL-7 signalling is motorized in human CD4
T cells
Blanche Tamarit, F. Bugault, A. Pillet, V. Lavergne,
P. Bochet, J. Thèze, T. Rose
Paris, France
W1.04 - NKT CELLS
W2.12.02 - TRAF6 regulates TCR signalling via interaction with and modification of LAT adapter.
J. Xie, J. Liang, L. Diao, A. Altman, Yingqiu Li
Guangzhou, China
W2.12.03 - TNF reverse signalling induces translocation of CKIP-1
Erno Duda, K. Juhasz, A. Zvara, Z. Balogi, A. Sonnleitner,
A. Borsodi
Szeged, Hungary
W2.12.04 - PI 3-kinase sub-pathways in lymphocyte
activation: regulation and functions of phosphatidylinositol (3,4)-bisphosphate
Aaron Marshall, N. Jayachandran, H. Li, I. Landego, S.
Pauls, S. Hou
Winnipeg, Canada
16.45-18.15
BROWN 2
16.45-18.15
AMBER 7+8
W7.07.02 - Bovine viral diarrhea virus actively replicate in bovine monocyte-derived dendritic cells and
use them as viral reservoirs
Alejandra V. Capozzo, O.L. Franco-Mahecha, W. Czepluch, D.A. Malacari, N. Cardoso, P.R. Grigera
Buenos Aires, Argentina
16.45-18.15
BROWN 1
Workshops August 26, 2013
W1.04.03 - The role of NKT cell TCR -chain on antigen specificity
Garth Cameron, K.S. Wun, O. Patel, D.G. Pellicci,
A.P. Uldrich, A.R. Howell, A.G. Brooks, S.A. Porcelli,
J. Rossjohn, D.I. Godfrey
Parkville, Australia
W1.04.04 - Bacterial CD1d restricted glycolipids induce IL-10 production by human Tregs upon crosstalk
with iNKT cells
Koen Venken, T. Decruy, S. Aspeslagh, S. Van Calenbergh,
B.N. Lambrecht, D. Elewaut
Ghent, Belgium
W1.04.05 - CD1d-restricted phosphatidic acid-reactive
T cells selectively inhibit glycolipid-reactive T cells
and protect against inflammatory liver disease
Ramesh C. Halder, C. Tran, R.R. Singh;
Los Angeles, United States
W1.04.06 - Invariant NKT cells in response to dengue
virus infection in human.
Ponpan Matangkasombut, W. Chan-in, P. Pongchaikul,
N. Tangthawornchaikul, S. Vasanawathana, W. Limpitikul,
P. Malasit, T. Duangchinda, J. Mongkolsapaya
Bangkok, Thailand
69
Chair: Shimon Sakaguchi (JPN)
Herman Waldmann (GBR)
Harnessing tolerance mechanisms in the clinic
Chair: Paul Hertzog (AUS)
Tadatsugu Taniguchi (JPN)
Regulation of inflammatory responses by HMGB1
and classical cytokines
Chair: Sergio Romagnani (ITA)
Art Weiss (USA)
Regulation of signal transduction by the T cell
antigen receptor
LL.34 - LUNCHTIME LECTURE
Chair: Giuseppe Pantaleo (CHE)
Andrew McMichael (GBR)
A dance of death: HIV-1 and immunodominant
T cells
LL.36 - LUNCHTIME LECTURE
Chair: Kathryn Wood (GBR)
Chris Goodnow (AUS)
The IgD enigma: removal of self-reactivity from
antibodies on IgD+ IgMlow anergic B cells
12.30 - 13.15
BROWN 3
LL.32 - LUNCHTIME LECTURE
12.30 - 13.15
SPACE 4
Chair: Ronald Germain (USA)
Mark M. Davis (USA)
Immunology taught by humans
12.30 - 13.15
SPACE 1+2
Chair: Francis Balkwill (AUS)
Robert D. Schreiber (USA)
Cancer immunoediting: basic mechanisms and
therapeutic implications
LL.30 - LUNCHTIME LECTURE
18.30 - 19.15
GOLD ROOM
PS.10 - PERSPECTIVES IN
IMMUNOLOGY
PL.09 - PLENARY LECTURE
12.30 - 13.15
AMBER 3+4
12.30 - 13.15
GOLD ROOM
12.30 - 13.15
BROWN 1+2
12.30 - 13.15
SPACE 3
12.30 - 13.15
AMBER 1+2
70
8.50 - 9.20
SPACE 1+2
PS.09 - PERSPECTIVES IN
IMMUNOLOGY
9.30 - 10.15
GOLD ROOM
8.50 - 9.20
GOLD ROOM
Main Lectures August 27, 2013
LL.31 - LUNCHTIME LECTURE
Chair: Vijay Kuchroo (USA)
Anne O’Garra (GBR)
The immune response in tuberculosis: from
mouse models to human disease
LL.33 - LUNCHTIME LECTURE
Chair: Cornelis Melief (NLD)
Francis Balkwill (GBR)
Targeting cancer related inflammation
LL.35 - LUNCHTIME LECTURE
Chair: Juan Rivera (USA)
Stephen J. Galli (USA)
Roles of mast cells and “allergic responses” in enhancing host resistance to venoms
LL.37 - LUNCHTIME LECTURE
Chair: Herman Waldmann (GBR)
Bali Pulendran (USA)
Innate control of adaptive immunity by the integrated stress response
PL.10 - PLENARY LECTURE
Chair: Andrew McMichael (GBR)
Sergio Romagnani (ITA)
Human effector CD4+ T cells
S25 - INNATE LYMPHOCYTES AND
MUCOSAL IMMUNITY
S26 - MICROBIOME AND MICROBE
ADAPTATION
Chairs: Kinston Mills (IRL)
Frances Brodsky (USA)
Hergen Spits (NLD)
S25.01 Characteristics of human innate lymphoid
cells in health and disease
Andrea Cerutti (ESP)
S25.02 Regulation of adaptive antibody responses
by the innate immune system
Kenya Honda (JPN)
S25.03 Regulation of Th17 and Treg cells by the
gut microbiota
Hilde Cheroutre (USA)
S25.04 Unique adaptive Immune defence @ the
mucosal front-line of the Intestine
Maria Rescigno (ITA)
S25.05 Complex interactions among immune and
non-immune cells in the gut
Chairs: Elizabeth A. Grice (USA)
Joel Dorè (FRA)
Yasmine Belkaid (USA)
S26.01 Commensal control of tissue immunity
Sidonia Fagarasan (JPN)
S26.02 Symbiotic regulatory loop between T cells,
IgA and gut microbiota
Mihai Netea (NLD)
S26.03 Trained immunity: innate immune
imprinting of host-microbe interaction
Alessandro Sette (USA)
S26.04 The role of human CD4 and CD8 T cells in
DENV and MTB immunity and immunopathology
Rachel R. Caspi (USA)
S26.05 The endogenous microbiome controls
development of spontaneous autoimmunity to
immunologically privileged neuroretina
10.20 - 12.25
SPACE 1+2
10.20 - 12.25
GOLD ROOM
Parallel Symposia August 27, 2013
S28 - IMAGING AND CELL
INTERACTIONS
Chairs: Francesca Di Rosa (ITA)
Stephen P. Schoenberger (USA)
Nicholas Restifo (USA)
S27.01 Transcriptional and epigenetic control of
T cell differentiation
Federica Sallusto (CHE)
S27.02 Class and specificity of the human T cell
response to commensals, pathogens, and
allergens
Marc K. Jenkins (USA)
S27.03 Origins of CD4+ memory T cells
David Gray (GBR)
S27.04 Tfh heterogeneity, memory and plasma
cell survival niches
Stephen P. Schoenberger (USA)
S27.05 Cellular and molecular regulation of
T help for CTL
10.20 - 12.25
BROWN 3
10.20 - 12.25
BROWN 1+2
S27 - IMMUNE MEMORY
S30 - TOLERANCE AND
TRANSPLANTATION
10.20 - 12.25
SPACE 4
10.20 - 12.25
SPACE 3
S29 - ALLERGY
Chairs: Francesca Levi Shaffer (ISR)
Walter Canonica (ITA)
Cezmi Akdis (CHE)
S29.01 Role of tissues in immune regulation in
allergic inflammation
Juan Rivera (USA)
S29.02 The high affinity receptor for IgE: Novel
discoveries in signaling and function
Gianni Marone (ITA)
S29.03 Mast cells and angiogenesis: from allergy
to tumor immunology
Bart Lambrecht (GBR)
S29.04 Epithelial cell - DC interaction in asthma
Rudolf Valenta (AUT)
S29.05 From allergen genes to allergy vaccines
Chairs: Antonella Viola (ITA)
Sarah Russell (AUS)
Mike L. Dustin (USA)
S28.01 Getting to the center of the
immunological synapse
Reinhold Förster (DEU)
S28.02 Killing me softly: how cytotoxic T cells
destroy virus-infected target cells in vivo
Ronen Alon (ISR)
S28.03 What determines the directionality of
leukocytes transendothelial migration?
Luca Guidotti (ITA)
S28.04 Visualizing and regulating the traffic of
pathogenic CD8+ T cells within the liver
Ronald Germain (ISA)
S28.05 Using advanced dynamic and multiplex
static imaging to probe innate and adaptive
immunity in vivo
Chairs: Claudio Ponticelli (ITA)
Andrea Biondi (ITA)
Kathryn Wood (GBR)
S30.01 Immunoregulation in transplantation
Megan Sykes (USA)
S30.02 Mechanisms of tolerance in patients
receiving combined kidney and bone marrow
transplantation
Narinder Mehra (IND)
S30.03 Clinical and immunological relevance of
antibodies in transplantation
Harvey Cantor (USA)
S30.04 Regulatory T-cells: therapeutic targets of
opportunity
Luigi Naldini (ITA)
S30.05 Genetic engineering of hematopoiesis for
treatment of human diseases
71
Late Breaking Sessions August 27, 2013
LB1 - LATE BREAKING SESSION - BASIC RESEARCH
Chair: Stefan H.E. Kaufmann (DEU)
13.30 - 14.30
GOLD ROOM
LB1.01 - Specification of innate type-2 lymphocytes by the transcriptional determinant Gfi1
Chauncey J. Spooner, J. Lesch, D. Yan, A. Abbas, M. Xu, J. DeVoss, H. Singh
San Francisco, United States
LB1.02 - Identification of a common monocyte progenitor
Jan Hettinger, D.M. Richards, J. Hansson, M.M. Barra, A.C. Joschko, J. Krijgsveld, M. Feuerer,
Heidelberg, Germany
LB1.03 - Distinct TLR4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation
Jaclyn W. McAlees, G.S. Whitehead, I. Harley, M. Cappelletti, C.L. Rewerts, A. Holdcroft, S. Divanovic, C.L. Karp, D.N. Cook
Cincinnati, United States
LB1.04 - Seeing is believing: visualization of the thymic T-cell development in a quantitative and non-invasive manner
Baubak Bajoghli, D. Inoue, M. Rauzi, P. Kuri, N. Aghaallaei, Y. Taniguchi, A. Toyoda, J. Wittbrodt, M. Leptin
Heidelberg, Germany
LB1.05 - A global approach to study viral antigen presentation using immunoproteomics
N.P. Croft, D.C. Tscharke, Anthony W. Purcell
Clayton, Australia
LB1.06 - Molecular characterization of a novel antigen specific, immunoglobulin expressing cell in immunized animals
with phenotypic characteristics of both granulocytes and lymphocytes
Jody D. Berry, E. Chronopoulou, A. Uribe-Benninghoff, J. Fisher, X. Ji, J. Elia, P. Waterman, D. Stupack
La Jolla, United States
LB2 - LATE BREAKING SESSION - TRANSLATIONAL RESEARCH
Chair: Jorge Kalil (BRA)
13.30 - 14.30
SPACE 1+2
LB2.01 - Identification of specific markers for type 2 (pro-allergic) human dendritic cells: interest as follow-up markers
for immunotherapy
Laurent Mascarell, C. Gueguen, H. Moussu, P. Moingeon, V. Baron-Bodo
Antony, France
LB2.02 - Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective
IFN-
Noriko M. Tsuji, T. Kawashima, H. Yan, Z. Guo, J. Carreras, R. Uchiyama, R. Fukui, T. Kaisho, S. Akira, K. Miyake, H. Tsutsui, T. Saito
Tsukuba, Japan
LB2.03 - Human antigen-specific CD4+CD25+CD134+CD39+ T cells are enriched for regulatory T cells and comprise a substantial proportion of CD4+ T cell antigen recall responses
Laura Cook, N. Seddiki, C. Munier, J. Zaunders, A.D. Kelleher
Sydney, Australia
LB2.04 - Human memory Helios- FOXP3+ Treg encompass induced Treg that express Aiolos and respond to IL-1 by downregulating their suppressor functions
Maha Ayyoub, C. Raffin, P. Pignon, C. Celse, D. Valmori
Nantes-Saint Herblain, France
LB2.05 - B lymphocytes undergo TLR2-dependent apoptosis upon Shigella infection mediated by the virulence factor
IpaD
Katharina Nothelfer, E.T. Arena, L. Pinaud, M. Neunlist, I. Belotserkovsky, C. Parsot, R. Raqib, B. Mozeleski, P.J. Sansonetti, A.
Phalipon
Paris, France
LB2.06 - CD14+CD16-, CD14+CD16+ and CD14dimCD16++ monocyte subsets are changed in obesity
Mariana Renovato-Martins, E. Devevre, K. Clément, A. Basdevant, C. Sautes-Fridman, I. Cremer, C. Poitou
Rio de Janeiro, Brazil
72
Workshops August 27, 2013
W6.11 - VACCINATION AND
IMMUNOTHERAPY FOR INFECTIOUS
DISEASES
W6.11.09 - Chimeric flagellin as the selfadjuvanting
antigen for antibody response against Helicobacter
pylori
J. Mori, Tanja Vranac, B. Smrekar, M. Cernilec, V. Curin
Serbec, S. Horvat, A. Ihan, M. Ben ina, R. Jerala
Ljubljana, Slovenia
Chairs: Nicholas King (AUS)
Maria Bellio (BRA)
IL6.11.01 - Novel Immune-modifying Nanoparticles
for the Treatment of Inflammatory monocyte-mediated Disease
D.R. Getts, R.L. Terry, M.T. Getts, C. van Vreden,
T.M. Ashhurst, S.J. Cordwell, E.B. Thorp, S. Bao, S.D. Miller,
Nicholas J.C. King
Sydney, Australia
W6.11.03 - IL-4 and IL-13 regulates CD8 co-receptor
expression to dampen the quality of anti-viral CD8+
T cell immunity following HIV-1 prime-boost vaccination
D.K. Wijesundara, R.J. Jackson, D.C. Tscharke,
Charani Ranasinghe
Canberra, Australia
W6.11.05 - Fusion of HCV non-structural antigen to
MHC-II associated invariant chain enhances T cell responses induced by vectored vaccines in non-human
primates
Antonella Folgori, S. Capone, M. Naddeo, A. Abbate,
M. Del Sorbo, M. Esposito, V. Ammendola, S. Colloca,
A. Nicosia, R. Cortese
Rome, Italy
W6.11.07 - Identification of novel Streptococcus
pneumoniae candidate vaccine antigen
Yaffa Mizrachi Nebenzahl, M. Pornoi, D. Kafka,
M. Shagan, A. Adawi, A. Ohayon, S. Dotan, M. Tal, R. Ellis,
R. Dagan
Beer Sheva, Israel
W6.11.08 - Diminished levels of pneumococcal polysaccharide (PPS) responding ‘B1 like’ cells and it’s corelation with poor anti PPS response post PPV-23 in
long term HAART cohorts
Anita S. Iyer, D.J. Leggat, N.M. Khaskhely, M. Westerink
Toledo, USA
W6.11.12 - Langerin negative dendritic cells promote
potent CD8+ T-cell priming after skin delivery of a recombinant adenovirus-based vaccine using microneedle arrays
V. Bachy, C. Hervouet, P. Becker, L. Chorro, L.M. Carlin,
S. Herath, S. Oh, S.Y. Kwon, F. Geissmann,
Linda S. Klavinskis
London, United Kingdom
W6.11.14 - microRNA-21 confers resistance against
CVB3-induced myocarditis by inhibiting PDCD4-mediated myocyte apoptosis
Wei Xu, J. He, Y. Yue, S. Xiong
Suzhou, China
W6.11.04 - Type 2 diabetes patients, both young and
elderly, have optimal B cell responses to the seasonal
influenza vaccine
Daniela Frasca, A. Diaz, M. Romero, A. Landin,
B.B. Blomberg
Miami, USA
W6.11.06 - Antigenization of bovine immunoglobulin
variable regions for development of novel vaccines
Yfke Pasman, A.K. Kaushik
Guelph, Canada
W6.11.11 - Necrotic cell vaccine against hepatitis C
Branka Grubor-Bauk, P. Latour, W. Yu, B. Loveland,
E. Gowans
Adelaide, Australia
W6.11.13 - Targeting of antigen via XCR1, the lineage
marker for cross-presenting dendritic cells, elicits potent CD8 cytotoxicity in vivo
Evelyn Hartung, M. Becker, A. Bachem, N. Reeg, Y. Yang,
A. Jäkel, H. Weber, V. Henn, H. Mages, R.A. Kroczek
Berlin, Germany
W1.03 - NK CELLS AND NK RECEPTORS
Chairs: Gunnur Deniz (TUR)
Cristina Bottino (ITA)
IL1.03.01 - Cross-talk bethween human natural killer
cells and macrophages
F. Bellora, R. Castriconi, A. Doni, A. Mantovani, A. Pessino,
A. Moretta, Cristina Bottino
Genova, Italy
15.10-18.15
BROWN 3
15.10-18.15
GOLD ROOM
W6.11.02 - Enhanced and accelerated memory CD8 T
cell formation by immunization with MVA-CD40L
Henning Lauterbach, J. Pätzold, R. Kassub, B. Bathke,
K. Brinkmann, P. Chaplin, M. Suter, H. Hochrein
Martinsried, Germany
15.10-18.15
GOLD ROOM
W6.11.01 - HIV CD4 based vaccine pre-immunization
increases CD8 T cell responses and confers protection
against challenge with a recombinant vaccinia virus
encoding HIV Gag-Pol proteins
Susan P. Ribeiro, A.D. Faria, R.R. Almeida, V.C. Santana,
D.S. Rosa, E.G. Kallas, J. Kalil, E. Cunha-Neto
São Paulo, Brazil
W6.11.10 - Improved assay for quantification of immunoreactive hemagglutinin for potency determination and stability analysis in trivalent influenza
vaccines using isotope dilution mass spectrometry
Carrie L. Pierce, T.L. Williams, W. Wang, J.L. Bundy,
J.R. Barr
Atlanta, USA
IL1.03.02 - Functionally distinct subsets of human NK
cells
Gunnur Deniz
Istanbul, Turkey
W1.03.01 - NK cell subsets isolated from human thymus differ from peripheral blood NK cells in their
phenotype and their cytotoxic and cytokine secreting
capabilities
S. Krieg, W. Kroeger, G. Heidkamp, K. Winterling, A. Purbojo,
R. Cesnjevar, A. Mackensen, D. Dudziak, Evelyn Ullrich
Frankfurt, Germany
W1.03.02 - Neuraminidase-mediated NKp46-dependent immune evasion mechanism of influenza viruses
Yotam Bar-On, O. Mandelboim
Jerusalem, Israel
73
W1.03.03 - NK cells from malignant pleural effusions
are not anergic but produce cytokines and display
strong anti-tumor activity on short-term IL-2 activation
Paola Vacca, S. Martini, L. Moretta, M.C. Mingari
Genoa, Italy
W1.03.04 - Unique CD56bright CD16+ NK cells infiltrate
regional metastatic lymph nodes from stage III melanoma patients
Meriem Messaoudene, G. Fregni, E. FourmentrauxNeves, J. Chanal, M. Avril, A. Caignard
Paris, France
15.10-18.15
BROWN 3
Workshops August 27, 2013
W1.03.05 - NK cells targeting of human and mouse
Cancer Initiating Cells
Rossana Tallerico, S. Di Franco, C. Maccalli, L. Conti,
S. Lanzardo, C. Garofalo, R. Sottile, M. Todaro, G. Stassi,
F. Cavallo
Catanzaro, Italy
Chairs: Carlo Agostini (ITA)
Angus W. Thomson (USA)
W1.03.12 - Defining the lethal hit: Perforin forms
transient pores on the target cell plasma membrane
to facilitate rapid access of granzymes during killer
cell attack
Jamie A. Lopez, O. Susanto, M.R. Jenkins, N. Lukoyanova,
V.R. Sutton, R.H.P. Law, J.C. Whisstock, H.R. Saibil,
J.A. Trapani, I. Voskoboinik
Melbourne, Australia
15.10-16.40
SPACE 1
15.10-18.15
BROWN 3
W6.14.02 - Induction of immune tolerance by antigen
loaded erythrocytes: Innovative therapy for therapeutic protein allergy
Magali Cremel, N. Guerin, W. Berlier, F. Horand,
Y. Godfrin
Lyon, France
W1.03.08 - Human M1 macrophages activate resting
NK cell antitumoral activities through IL-15/IL-15RA
transpresentation
Irene Mattiola, M. Pesant, P. Tentorio, D. Mavilio,
M. Locati
Milan, Italy
W1.03.11 - Innate immunity driving tumor angiogenesis: the role of NK cells in non-small cell lung cancer
Antonino Bruno, F. Chiara, A. Pagani, I. Andrea,
M. Spagnoletti, C. Capella, G. Ferlazzo, L. Mortara,
D. Noonan, A. Albini
Milan, Italy
74
W6.14.01 - Immunological outcomes during 1 year of
treatment with the anti-IL-12/23 p40 monoclonal antibody ustekinumab for psoriasis
Aurore Rozieres, C. Lambert, C. Paul, K. Reich,
M. Brunori, P. Bergmans, E. Martens, E. Rizova, J. Nicolas
Lyon, France
W1.03.07 - Regulation of the activating NKp30 ligand
B7-H6 in tumor cells
Nathalie Fiegler, S. Textor, A. Arnold, A. Rölle, I. Oehme,
K. Breuhahn, G. Moldenhauer, M. Witzens-Harig,
A. Cerwenka
Heidelberg, Germany
W1.03.10 - The viral KSHV chemokine vMIP-II inhibits
the migration of naive and activated human NK cells
by antagonizing two distinct chemokine receptors
Rachel Yamin, N. Stanietsky-Kaynan, A. Glasner,
Y. Bar-On, S. Elias, C. Gur, O. Mandelboim
Jerusalem, Israel
W1.03.14 - Analyzing and modeling the dynamics of
differentiating and adoptively transferred NK cells in
patients undergoing hematopoietic stem cell transplantation
M. Killig, B. Friedrichs, J. Meisig, M. Luetke-Eversloh,
L. Uharek, Chiara Romagnani, C. Ranasinghe
Berlin, Germany
W6.14 - IMMUNOSUPPRESSIVE AND
TOLEROGENIC TREATMENTS
W1.03.06 - Novel mouse models reveal how expression of NKG2D and its ligands on various cell subsets
affects immune responses
Maelig G. Morvan, M. Champsaur, N.L. Johnson, V. Sexl,
L.L. Lanier
San Francisco, USA
W1.03.09 - Natural killer cell distribution and traffikking in normal and neoplastic human tissues
Paolo Carrega, I. Bonaccorsi, E. Di Carlo, M. Mingari,
L. Moretta, G. Ferlazzo
Genoa, Italy
W1.03.13 - Gap Junction intercellular communication
induces NK cell activation and modulates cytotoxic
capacity
Israel J. Guerrero, A. Tittarelli, A. Mendoza-Naranjo,
M. Farías, M. López, B. Chambers, F. Salazar-Onfray
Santiago, Chile
W6.14.03 - Therapeutic role of the novel negative
checkpoint regulator VISTA in murine autoimmune
disease models
Sabrina Ceeraz, I. Le Mercier, P. Sergent, A. Schned,
C. Burns, R. Noelle
Lebanon, USA
W6.14.04 - IL-7 receptor blockade by monoclonal antibody to IL-7R induces islet allograft tolerance and
long-term skin allograft survival through inhibition
of T cell reconstitution
Hoa L. Mai, F. Boeffard, J. Lepourry, R. Danger,
B. Martinet, B. Vanhove, S. Brouard, J.P. Soulillou
Nantes, France
W6.14.05 - Control of autoimmunity by Treg-inducing
liver sinusoidal endothelial cells
Antonella Carambia, B. Freund, D. Schwinge, O.T. Bruns,
S.C. Salmen, H. Ittrich, R. Reimer, M. Heine, J. Heeren,
J. Herkel
Hamburg, Germany
W6.14.06 - Induction of immunosuppression by mesenchymal stem cells
Yufang Shi
Shanghai, China
Workshops August 27, 2013
W5.07 - ANIMAL MODELS OF
AUTOIMMUNITY
W6.12.04 - Soluble FGL2 induces tubular epithelial cells
apoptosis in renal allograft rejection
Zitong Zhao, C. Yang, L. Wang, L. Li, T. Zhao, L. Hu,
R. Rong, M. Xu, T. Zhu
Shanghai, China
IL5.07.01 - Experimental model of autoimmune prostatitis
Clelia Maria Riera, M. Maccioni, R. Motrich, V. Rivero
Cordoba, Argentina
W5.07.02 - Small intestine inflammation in roquinmutant and roquin-deficient mice
J.S. Schaefer, D. Montufar-Solis, N. Vigneswaran,
John R. Klein
Houston, USA
W2.07 - PERIPHERAL TOLERANCE
AND LYMPHOCYTE ANERGY
W5.07.03 - Tolerance induction by hair-specific keratins in murine alopecia areata
Ulrike Erb, P. Freyschmidt-Paul, M. Zoeller
Heidelberg, Germany
Chairs: Bonnie Blomberg (USA)
Sachiko Miyake (JPN)
W5.07.04 - Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel
model of sialoadenitis in wild-type mice
Davide Lucchesi, M. Bombardieri, S. Nayar, G. Proctor,
F. Barone, C.D. Buckley, C. Pitzalis
London, United Kingdom
W2.07.01 - Induction of antigen-specific tolerance
upon infusion of Fc-fusion proteins via the maternofetal interface
Nimesh Gupta, Y. Meslier, S. André, S. Culina, S. Delignat,
B.L. Salomon, R. Mallone, S. Kaveri, S. Lacroix-Desmazes
Paris, France
W5.07.05 - Phenotype conversion from rheumatoid
arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcRIIB-deficient
C57BL/6 mice
Sachiko Hirose, S. Kawano, Q. Lin, H. Amano, T. Kaneko,
K. Nishikawa, H. Tsurui, N. Nishimura, T. Shirai
Tokyo, Japan
W2.07.02 - Ly9 (CD229) cell surface receptor ameliorates autoimmune response
Xavier Romero, J. de Salort, P. Engel
Barcelona, Spain
W5.07.06 - SPARC deficiency promotes lupus like autoimmunity by defective clearance of dead PMN
Caterina Vitali, S. Sangaletti, C. Tripodo, C. Bassani,
M. Parenza, M.P. Colombo
Milan, Italy
W6.12 - ORGAN TRANSPLANTATION
Chairs: Birgit Sawitzki (DEU)
Chiara Romagnani (ITA)
15.10-16.40
SPACE 3
W6.12.05 - Association of splenic CD11c+ B-cell population with long-term graft tolerance in mouse cardiac transplantation model
T. Wang, Tongmin Wang, J. Guo, J. Tao, J. Yang, J. Zhu,
W. Yang
Kunming, China
W6.12.06 - Tolerance induction to immunogenic
grafts via antigen-specific Tregs without the need for
chronic immunosuppression
Matthias Hardtke-Wolenski, N. Seltrecht, N. Mpofu,
R. Taubert, F. Noyan, M.P. Manns, E. Jaeckel
Hannover, Germany
W6.12.01 - Monitoring indirect allorecognition in
renal transplant recipients
Eytan Breman, P.P. van Miert, M.H. Heemskerk,
D. Roelen, F.H. Claas, C. van Kooten
Leiden, Netherlands
W6.12.02 - In vitro and in vivo characterization of IL9 producing alloreactive T cells
Katarina Stanko, J. Schumann, U. Schliesser, C. Appelt,
K. Vogt, B. Sawitzki
Berlin, Germany
W6.12.03 - Experimental chronic lung allograft damage
S. Atanasova, A. Evers, D. Jonigk, K. Petri, A. Zakrzewicz,
M. Obert, J. Schmitz, M. Hirschburger, W. Padberg,
Veronika Grau
Giessen, Germany
15.10-16.40
SPACE 4
15.10-16.40
SPACE 2
W5.07.01 - Effector memory exhausted tissue resident CD8 T cells accumulate during chronic experimental autoimmune uveitis
Joanne Boldison, D. Copland, A.D. Dick, L.B. Nicholson
Bristol, United Kingdom
15.10-16.40
SPACE 3
Chairs: Clelia Maria Riera (ARG)
Costantino Pitzalis (GBR)
W2.07.03 - An agonistic anti-BTLA mAb (3C10) induced generation of IL-10 dependent regulatory CD4+ T
cells and prolongation of murine cardiac allograft
Masateru Uchiyama, X. Jin, Q. Zhang, L. Yu, H. Bashuda,
H. Matsuda, H. Yagita, M. Niimi
Tokyo, Japan
W2.07.04 - Upregulation of inhibitory molecules in T
cells is associated with altered functions of dendritic
cells by HIV-1 and activation of the P38MAPK/STAT3
pathway
Esaki M. Shankar, K.F. Che, M. Larsson
Kuala Lumpur, Malaysia
W2.07.05 - IL-15 reverses age-related CD8+ T cell inactivation with increasing IFN production and improves survival in aged septic mice
Shigeaki Inoue, K. Suzuki-Utsunomiya, Y. Komori,
S. Inokuchi, K. Hozumi, T. Sato
Isehara, Japan
W2.07.06 - Upregulation of glucocorticoid-induced leucine zipper by hepatocyte growth factor promotes tolerogenic dendritic cells and inhibits experimental
autoimmune encephalomyelitis
Mahdia Benkhoucha, N. Molnarfi, M. Santiago-Raber,
G. Schneiter, P. Lalive
Geneva, Switzerland
75
Workshops August 27, 2013
W3.15 - B AND T CELL MEMORY
IL3.15.01 - Regulation of human CD8+ T cell effector
functions
Rene A. Van Lier, K. Hertoghs, F. Vieira Braga,
M. Brouwer, L. Aarden, I. Derks, E. Eldering, M. Nolte,
I. ten Berge, K. van Gisbergen
Amsterdam, Netherlands
W3.15.01 - Disparate individual fates compose robust
CD8+ T cell immunity
Veit R. Buchholz, M. Flossdorf, I. Hensel, L. Kretschmer,
B. Weissbrich, P. Gräf, M. Schiemann, T. Höfer, D.H. Busch
Munich, Germany
15.10-16.40
AMBER 1+2
W6.04.03 - Survivin as a target for therapeutic RNA
interference in experimental arthritis
Sofia E.M. Andersson, M.N.D. Svensson, M.C. Erlandsson,
I. Jonsson, K.M.E. Andersson, M.I. Bokarewa
Gothenburg, Sweden
Rene Van Lier (NLD)
Attilio Bondanza (ITA)
15.10-16.40
AMBER 3+4
Chair:
W3.15.02 - Late IL-2 signals limit effector CD4 T cell
contraction and serve as a checkpoint for transition
to memory
Kai K. McKinstry, T.M. Strutt, A.M. Cooper, S.L. Swain
Worcester, USA
W5.05 - ENVIRONMENTAL FACTORS
IN AUTOIMMUNITY AND ALLERGY
Chairs: Yehuda Schoenfeld (ISR)
Eva Sverremark-Ekstrom (SWE)
W3.15.04 - The transcription factor Zeb2 plays a role
in promoting terminal differentiation of CD8+ T-cells
through repression of the miR-200 family
Claudia X. Dominguez, S.M. Kaech
New Haven, USA
IL5.05.01 - ‘ASIA’ - Autoimmune (Auto-inflammatory)
syndromes induced by adjuvants
Yehuda Shoenfeld
Tel Hashomer, Israel
W3.15.05 - IL-12-mediated STAT4 signaling and T-cell
receptor (TCR) signal strength cooperate in induction
of CD40L in human and mouse CD8+ T cells
Regina Stark, A. Haese, S. Durlanik, K. Hoffmann,
N. Matzmohr, D. Zehn, M. Frentsch, A. Thiel
Lausanne, Switzerland
15.10-16.40
AMBER 3+4
Chairs: Marco Matucci Cerinic (ITA)
Johannes Roth (DEU)
W6.04.01 - Human cathelicidin-derived peptide IG-19
regulates cytokine IL-32-induced inflammation in
human blood mononuclear cells, and provides protection in a murine model of arthritis
Ka-Yee (Grace) Choi, L.N.Y. Chow, M. Bossert,
T. Klonisch, J. Uzonna, N. Mookherjee
Winnipeg, Canada
W6.04.02 - The pro-inflammatory activities of IL-6 are
mediated by the soluble Interleukin-6 receptor via
trans-signalling
Stefan Rose-John
Kiel, Germany
76
IL5.05.02 - Early-life microbial exposures and allergy
development - exploring the role of herpesviruses
Eva Sverremark-Ekstrom
Stockholm, Sweden
15.10-16.40
AMBER 5+6
W6.04 - TREATMENT OF RHEUMATOID
ARTHRITIS AND OTHER
INFLAMMATORY JOINT DISEASES
W6.04.05 - Blockade of CCR6 and CCL20 interaction
ameliorates arthritis and contact hypersensitivity
reaction in mice
Kenzo Muramoto, A. Bender, T. Horizoe, M. Nishimura,
T. Imai
Chuo-ku, Japan
W6.04.06 - The effect of CXCL10 blockade in C protein-induced myositis
Yeong-Wook Song, J. Kim, J. Choi, S. Chang, K. Shin,
S. Park, E. Lee, E. Lee, H. Kawachi, H. Kohsaka
Seoul, Republic of Korea
W3.15.03 - Id2-mediated inhibition of E2A represses
memory CD8 T cell differentiation
Frédérick Masson, M. Minnich, M. Olshansky, A. Kallies,
T.P. Speed, M. Busslinger, S.L. Nutt, G.T. Belz
Parkville, Australia
W3.15.06 - Survival of CD8 memory T cell precursors
depends on NKG2D mediated PI3K signalling and
Mcl-1 induction
Felix M. Wensveen, M. Lenarti , V. Jelen i , N.A.W. Lemmermann, A. ten Brinke, S. Jonji , M. Colonna, B. Poli
Rijeka, Croatia
W6.04.04 - Critical role of all-trans retinoic acid in stabilizing human nTregs under inflammatory
conditions
Songguo Zheng, Z. Liu
Shanghai, China
W5.05.01 - Ectopic lymphoid structures support Epstein-Barr virus persistence and autoreactive plasma
cell infection in Sjogren’s syndrome salivary glands
C. Croia, B. Serafini, N. Sutcliffe, A. Tappuni, F. Aloisi,
C. Pitzalis, Michele Bombardieri
London, United Kingdom
W5.05.02 - A single non-synonymous polymorphism
of TLR2 is sufficient to recapitulate the variability of
experimental multiple sclerosis
Giuseppe Migliara, G. Di Sante, A. Piermattei, C. Nicolò,
M. Valentini, A. Procoli, M. Geloso, M. Corbi, A. Sgambato,
F. Ria
Rome, Italy
W5.05.03 - High salt diet exacerbates autoimmune
disease by induction of pathogenic Th17 cells
Markus Kleinewietfeld, A. Manzel, R.A. Linker,
D.N. Muller, D.A. Hafler
New Haven, USA
W5.05.04 - Impact of infectious agents on trafficking
of effector T cells is mediated by a polymorphic site
of TLR2 and CD44 isoforms expression
Gabriele Di Sante, E. De Paolis, A. Piermattei,
M. Valentini, G. Migliara, C. Nicolò, G. Constantin,
E. Giorda, G. Delogu, F. Ria
Rome, Italy
15.10-16.40
AMBER 5+6
Workshops August 27, 2013
W7.01 - IMAGING OF THE IMMUNE
SYSTEM
W5.05.05 - Aryl hydrocarbon receptor modulates psoriatic skin inflammation
Paola Di Meglio, J.H. Duarte, H. Ahlfors, N.D.L. Owens,
F. Villanova, K. Hirota, M. Gilchrist, F.O. Nestle,
U. Mrowietz, B. Stockinger
London, United Kingdom
Chairs: Matteo Iannacone (ITA)
Jens Stein (CHE)
IL7.01.01 - In vivo imaging of intrahepatic effector
CD8 T cell dynamics
Matteo Iannacone
Milan, Italy
W5.05.06 - IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of
protease allergen-induced allergic airway inflammation
S. Kamijo, Toshiro Takai, M. Hara, A. Matsuda, H. Saito,
S. Nakae, K. Sudo, S. Ichikawa, H. Ogawa, K. Okumura
Tokyo, Japan
IL7.01.02 - Intracellular control of central versus effector memory T cell migration and activation
Jens V. Stein
Bern, Switzerland
W7.01.01 - Lateral distribution of the T cell receptor
and membrane lipid detected by high resolution secondary ion mass spectrometry
Feng Wang, M.M. Lozano, B.F. Lillemeier, S.G. Boxer,
M.M. Davis
Stanford, USA
W4.12 - MICROBIOME, GUT FLORA
AND INFLAMMATION
IL4.12.01 - Adenoma induced reshaping of the gut
microbiome controls host dependent progression of
colon cancer
V.R. Jala, P. Maturu, E. Krishnan, S. Mathis, S.R. Bodduluri,
M. Wang, R. Knight, Haribabu Bodduluri
Louisville, United States
IL4.12.02 - Control of mucosal immune responses by
vitamin A
Reina Mebius, G. Goverse, B. Olivier, R. Molenaar, M.
Knippenberg, M. Greuter, T. Konijn, T. O’Toole, G. Bouma
Amsterdam, Nederland
15.10-16.40
BROWN 1
Chairs: Haribabu Bodduluri (USA)
Reina Mebius (NLD)
W4.12.02 - Dietary fibers downregulate low-grade inflammation systemically in mice
Stine B. Metzdorff, C.H.F. Hansen, A.G. Christensen,
A. Bergström, T.R. Licht, A.K. Hansen, H. Frøkiær
Frederiksberg, Denmark
W7.01.05 - Single cell analysis of molecular networks
involved in T cell activation and signalling.
Ruth Brignall, J. Bagnall, L. Schmidt, D. Spiller,
D.A. Jackson, M. Travis, M.R.H. White, P. Paszek
Manchester, United Kingdom
W4.12.03 - Critical IL-23 based cross regulation of colonic DCs by macrophages protects mice from Citrobacter challenge
Tegest Aychek, A. Mildner, S. Yona, K. Kim, S. Jung
Rehovot, Israel
W7.01.06 - Dynamic expression of co-stimulatory and
co-inhibitory receptors regulates termination of T
cell-DC interaction during CD8 T cell activation
Mario Perro, J. Godec, S. Loughhead, I. Mazo, S. Henrickson, W.N. Haining, A.H. Sharpe, U.H. von Andrian
Boston, USA
W4.12.04 - Fungal communities throughout the intestine and their role in intestinal inflammation
Iliyan D. Iliev, V. Funari, D. Underhill
Los Angeles, USA
W4.12.05 - Diet and gut microbiota play a key role in
autoimmune diabetes
E. Marino, Eliana Marino
Melbourne, Australia
W4.12.06 - Probiotics as immune-regulators in the rat
experimental autoimmune encephalomyelitis and
myasthenia gravis models
Chiara Cordiglieri, R. Marolda, M. Elli, R. Mantegazza,
F. Baggi
Milan, Italy
W7.01.03 - Comprehensive confocal imaging and 3D
computer analysis of blood and lymphatic vascular
channels across entire lymph nodes
Inken Kelch, G. Bogle, A. Phillips, I.J. LeGrice, G.B. Sands,
D.A. Gerneke, C.J. Mansell, P.R. Dunbar
Auckland, New Zealand
W7.01.04 - Skin patrol by tissue-resident CD8+ T cells
Silvia Ariotti, J.B. Beltman, G. Chodaczek, M. Hoekstra,
A.E. van Beek, R. Gomez-Eerland, L. Ritsma, J. van Rheenen, A. Maree, T. Zal
Amsterdam, Netherlands
W1.12 - LECTINS AND
GLYCOIMMUNOLOGY
Chairs: Fu-Tong Liu (USA)
Chitra Mandal (IND)
15.10-16.40
BROWN 2
15.10-16.40
AMBER 7+8
W4.12.01 - The molecular characterization of Helicobacter activated regulatory B cells and their role in
gastric immunopathology
Ayca Sayi Yazgan, M. Karayılan, N. Mansur, A. Müller
Istanbul, Turkey
W7.01.02 - Role of colonic lymphoid patch dendritic
cells in patrolling the colonic lumen, transporting antigen, and imprinting homing of T cells to the colon
Jay A. Berzofsky, A. Dzutsev, A. Hogg, L. Koo, H. Yu,
R. Goldszmid, J. Kabat, Y. Sui, O. Schwartz, G. Trinchieri
Bethesda, USA
IL1.12.01 - Galectins in Inflammation and Immunity
Fu-Tong Liu
Taipei, Taiwan
IL1.12.02 - Molecular interplay between sialic acids
and siglecs in subversion of host innate immune response by Pseudomonas aeruginosa
Chitra Mandal, B. Khatua
Kolkata, India
77
W1.12.01 - C-type lectin MCL is a receptor for mycobacterial cord factor TDM and is critical for Mincle induction
Yasunobu Miyake, K. Toyonaga, D. Mori, S. Kakuta,
Y. Hoshino, Y. Iwakura, S. Yamasaki
Fukuoka, Japan
W6.15.03 - Sub-visible particles in protein therapeutics - are they responsible for the induction of unwanted immune responses?
Christian Lubich, M. Malisauskas, T. Prenninger, C. Lenk,
E. Hopfner, F. Scheiflinger, B.M. Reipert
Vienna, Austria
W1.12.02 - Targeting C-type lectin receptors on dendritic cells for neonatal adjuvant setting
Sebastien Lemoine, B. Jaron, E. Deriaud, C. Leclerc,
R. Lo-Man
Paris, France
W6.15.04 - Assessing immune toxicity of engineered
nanoparticles: modulation of inflammation in a novel
in vitro model based on human primary monocytes
Yang Li, P. Italiani, E. Caslas, V.F. Puntes, D. Boraschi
Pisa, Italy
W1.12.03 - A novel role of beta-glucan in improving
anti-tumor immunity by regulating monocytic myeloid-derived suppressor cells
Jie Tian, K. Ma, H. Guo, J. Chen, H. Xu, S. Wang
Zhenjiang, China
16.40-18.15
SPACE 1
15.10-16.40
BROWN 2
Workshops August 27, 2013
W1.12.04 - Soluble CD52 is a negative regulator in
the innate immune system
Maryam Rashidi, Y. Zhang, E. Bandala-Sanchez,
J.M. Wentworth, J. Vince, L.C. Harrison
Melbourne, Australia
W6.15.06 - Molecular mechanisms associated to a
new combined therapy for multiple sclerosis
Giselle Pentón-Rol, N. Lagumersindez-Denis, M. Cervantes-Llanos M, V. Falcón-Cama, L. Muzio, M. Nazabal-Gálvez, T. Veliz, R. Furlan, A. Mantovani, E. Pentón-Arias
Havana, Cuba
W1.12.05 - Galectin-3 promotes cell-to-cell transmission of HIV-1
S.F. Wang, D.K. Hsu, Y.M.A. Chen, Huan Y. Chen, F.T. Liu
Taipei, Taiwan
W6.05 - PREVENTION AND
INTERVENTION IN ALLERGY
Chairs: Sergio Bonini (ITA)
Revaz Sepiashvili (RUS)
W1.12.06 - Galectin 3 affects DCs:NKT cell interaction
in the development of GalCer-induced hepatitis
Vladislav B. Volarevic, M. Milovanovic, B. Simovic Markovic, S. Bojic, M. Stojanovic, N. Arsenijevic, G. Besra,
M.L. Lukic
Kragujevac, Serbia
IL6.05.01 - Allergy in the CIS-countries
Revaz Sepiashvili, T. Slavyanskaya;
Moscow, Russian Federation
W6.05.01 - Application of HLA-II peptide tetramers
vs. allergen-induced proliferation for identification
of allergen-specific CD4 T cells in the model of mugwort pollen allergy
Beatrice Jahn-Schmid, D. Van Hemelen, V. Mahler, I. Fae,
G. Fischer, B. Bohle
Vienna, Austria
W6.15 - IMMUNOPHARMACOLOGY
16.40-18.15
SPACE 1
IL6.15.02 - Molecular mechanisms associated to a
new combined therapy for multiple sclerosis
Giselle Penton Rol, N. Lagumersindez-Denis,
M. Cervantes-Llanos, V. Falcón-Cama, L. Muzio,
M. Nazabal-Gálvez, T. Veliz, R. Furlan, A. Mantovani,
E. Pentón-Arias
Havana, Cuba
W6.15.01 - L-GILZ forms a complex vith p53 and
mdm2 and suppresses tumor growth through p53 activation
Emira M. Ayroldi, M. Petrillo, A. Bastianelli, S. Ronchetti,
C. Marchetti, G. Nocentini, L. Cannarile, C. Riccardi
Perugia, Italy
W6.15.02 - Bringing together the potential of immune cells and the power of new drugs to target
cancers by nanoparticles
Cinzia Garofalo, L. Izzo, R. Strong, V. Groh, R. Sottile,
R. Tallerico, D. Pappalardo, E. Carbone
Catanzaro, Italy
78
16.40-18.15
SPACE 2
Chairs: Giselle Penton Rol (CUB)
Diana Boraschi (ITA)
IL6.15.01 - Modelling human inflammation in vitro
with human blood monocytes
Diana Boraschi, P. Giungato, Y. Li, P. Italiani
Pisa, Italy
W6.15.05 - Protein kinase C regulates inducible nitric
oxide synthase expression through IRF1
Tiina Leppänen, R. Korhonen, M. Laavola, R. Nieminen,
R.K. Tuominen, E. Moilanen
Tampere, Finland
W6.05.02 - Antibodies specific for the junction of CH4
domain and CmX in membrane-bound IgE are potentially useful for down-regulating mIgE-B lymphocytes
Chien-Jen Lin, N. Chen, J. Chen, Y. Shiung, C. Lu,
A.F. Hung, P.C. Wu, T. Chang
Taipei, Taiwan
W6.05.03 - Mast cell-derived prostaglandin D2 suppresses intestinal mastocytosis in food allergy
Tatsuro Nakamura, S. Matsumoto, K. Aritake, M. Hori,
H. Ozaki, Y. Urade, T. Murata
Tokyo, Japan
W6.05.04 - Robust long-term tolerance in IgE-mediated allergy through transfer of allergen-expressing
bone marrow cells
Ulrike Baranyi, B. Linhart, A.M. Farkas, K. Hock,
T. Rülicke, R. Valenta, T. Wekerle.
Vienna, Austria
W6.05.05 - Sublingual immunotherapy induces regulatory T cells in cervical lymph node of murine allergic
rhinitis model
Hideyuki Kawauchi, T. Yamada, M. Tongu, Q. Infei,
N. Aoi, I. Morikura, T. Fuchiwaki, F. Takaiwa
Izumo, Japan
16.40-18.15
SPACE 2
Workshops August 27, 2013
W6.05.06 - Effective suppression of grass-pollen induced asthma manifestations by subcutaneous and
sublingual immunotherapy in a mouse model
Laura Hesse, M. Nawijn, R. Gras, H. Oude Elberink,
J. Brimnes, A. van Oosterhout
Groningen, Netherlands
W3.10.02 - Transcriptional regulation of human Th17
cell differentiation
Subhash K. Tripathi, Z. Chen, T. Äijö, A. Larjo, V. Salo,
S. Tuomela, H. Lähdesmäki, R. Lahesmaa
Turku, Finland
W3.10.03 - Protein C receptor regulates pathogenic
phenotype of Th17 cells
Yasuhiro Kishi, C. Wang, C. Wu, N. Yosef, A. Regev,
N. Joller, V. Kuchroo
Boston, USA
Chairs: Franco Locatelli (ITA)
Mauricette Michallet (FRA)
W6.13.01 - PI3K-independent signal contributes to
ICOS-mediated T-cell costimulation in acute GVHD in
mice
Jun Li, X. Yu
Changsha, China
16.40-18.15
SPACE 4
W6.13 - BONE MARROW
TRANSPLANTATION AND GRAFT
VERSUS HOST DISEASE
W6.13.04 - Fetal membrane cells for treatment of steroid-refractory acute GVHD
Helen Kaipe, T. Erkers, S. Nava, M. Uzunel, E. Iwarsson,
R. Conrad, M. Westgren, J. Mattsson, O. Ringdén
Stockholm, Sweden
W3.02 - ROLE OF THE STROMA IN
INNATE AND ADAPTIVE IMMUNITY
W6.13.05 - CMV reactivation and kinetics of NK cell
reconstitution in 439 patients after allogeneic hematopoietic stem cell transplantation
H. Moins-Teisserenc, Vissal David Kheav, R. Peffault de
Latour, M. Busson, C. Scieux, G. Maki, A. Xhaard, G. Socié,
A. Toubert, H. Moins-Teisserenc
Paris, France
IL3.02.01 - Role of Lymph node structure in adaptive
immunity to influenza virus
M.C. Woodruff, C.H. Herndon, S.S. Turley,
Michael C. Carroll
Boston, United States
W6.13.06 - CD8+ T-cells expressing the homing receptors CCR7 and CD62L mediate the pathogenesis of
GVHD
A. Kreutzman, Ixaso Sainz Portero, M. Royg, V. Gómez
García Soria, A. Ramirez, C. Muñoz Calleja
Madrid, Spain
W3.10 - Th17 CELLS
Chairs: Megan Levings (CAN)
Pierre Miossec (FRA)
16.40-18.15
SPACE 4
W3.10.05 - Development and stability of human Th17
cells require endogenous NOS2 and cGMPc/GK-dependent NO signalling
N. Obermajer, J. Wong, K. Chen, M. Scott, S. Khader,
J. Kolls, K. Odunsi, R. Edwards, T. Billiar, Pawel Kalinski
Pittsburgh, USA
W3.10.06 - Evidence of a transient nature of the Th17
phenotype of CD4+CD161+ T cells in the synovial fluid
of juvenile idiopathic arthritis patients
Laura Maggi, L. Cosmi, V. Santarlasci, M. Capone,
V. Querci, M. Rossi, F. Liotta, E. Maggi, F. Annunziato,
S. Romagnani
Florence, Italy
W6.13.03 - In vitro-generated myeloid-derived suppressor cells inhibit GVHD while preserving the graftversus-tumor effect
Joanna J. Messmann, M.B. Lutz, F. Leithäuser, K.M. Debatin, G. Strauss
Ulm, Germany
Chairs: Michael C. Carroll (USA)
David Naor (ISR)
16.40-18.15
AMBER 1+2
16.40-18.15
SPACE 3
W6.13.02 - CD11b+ NK cells are the main effector NK
cell subpopulation that impairs GVHD
K. Meinhardt, I. Kroeger, R. Bauer, D. Dudziak, M. Rehli,
A. Mackensen, Evelyn Ullrich
Frankfurt, Germany
W3.10.04 - IL-17A secretion by CD8+ T cells supports
Th17-mediated autoimmune encephalomyelitis
Magdalena Huber, S. Heink, A. Pagenstecher,
K. Reinhard, J. Ritter, A. Visekruna, A. Guralnik, T. Kamradt,
M. Lohoff
Marburg, Germany
IL3.02.02 - Stroma-derived Hyaluronan induces CD44dependent apoptosis in diabetic insulin-secreting
cells
David Naor, N. Assayag-Asherie, E.A. Turley, I. Raz
Jerusalem, Israel
W3.02.01 - Endocytosis and recycling of immune
complexes by follicular dendritic cells enhances B cell
binding and activation
Balthasar A. Heesters, P. Chatterjee, Y. Kim, S.F. Gonzalez, M.P. Kuligowski, T. Kirchhausen, M.C. Carroll
Boston, USA
IL3.10.01 - Contribution of IL-17 to the chronicity of
inflammatory diseases
Pierre Miossec
Lyon, France
W3.02.02 - Dynamics of plasma cell survival niches in
the bone marrow
S. Zehentmeier, K. Roth, Ö. Sercan, H. Chang, Z. Cseresnyes, R. Niesner, A. Radbruch, Anja E. Hauser
Berlin, Germany
W3.10.01 - Phosphorylation status determines the divergent roles of Smad2 and Smad3 as STAT3 cofactors in Th17 differentiation
Jeong-Hwan Yoon, K. Sudo, S. Park, M. Kuroda, S. Nakae,
T. Yamashita, J. Ju, K. Matsuzaki, T. Sumida, M. Mamura
Tokyo, Japan
W3.02.03 - Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in
mouse bone marrow
Julie Tellier, F. Mourcin, C. Breton, P. Narang, L. Chasson,
A. Jorquera, M. Coles, S. Mancini, C. Schiff
Parkville, Australia
79
16.40-18.15
AMBER 1+2
Workshops August 27, 2013
W5.21 - MYELO - AND LYMPHO-PROLIFERATIVE DISORDERS
W3.02.04 - Local complement activation abrogates
the tumor-endothelial barrier and mediates T cell homing and tumor immune attack
Andrea Facciabene, F. De Sanctis, K. Balint, P. Magotti,
J. Lambris, G. Coukos
Philadelphia, USA
Chairs: Vito Pistoia (ITA)
Angelo Vacca (ITA)
IL5.21.01 - Cytokines and B cell lymphoproliferative
disorders
Vito Pistoia, I. Airoldi
Genova, Italy
W3.02.05 - Alterations in stromal cell compartment
during thymus atrophy induced by P. brasiliensis infection
Thiago Alves da Costa, R. Di Gangi, C. Francelin,
R. Thomé, L. Verinaud
Campinas, Brazil
W5.21.01 - Variation in B cell receptor signalling between stereotypic and heterogeneous chronic lymphocytic leukemia
Alice F. Muggen, L.P. Kil, S. Yuvaraj, J.J.M. van Dongen,
R.W. Hendriks, A.W. Langerak
Rotterdam, Netherlands
W3.02.06 - A quasi clone specific mechanism for the
regulation of the size of the primary CD8 T cell response
Richard W. Dutton, T. Zou
Worcester, USA
W5.21.02 - The bone-targeting of IL-27 is mediated
by the poly-glutamic acid motif of its p28 subunit
Aurélie Jeanne Tormo, L. Beaupré, G. Elson, S. Crabé,
J. Gauchat
Montreal, Canada
W5.14 - PSORIASIS AND SKIN
DISEASES
W5.21.03 - MIP-1/CCL3-mediated maintenance of
leukemia initiating cells in the initiation process of
chronic myeloid leukemia
Naofumi Mukaida, T. Baba
Kanazawa, Japan
W5.14.01 - Innate immune activation promotes autoimmune response in generalized pustular psoriasis
Akiko Arakawa, S. Vollmer, B. Summer, Y. Kawakami,
B. Petra, P. Thomas, A. Wollenberg, J. Schauber, T. Ruzicka,
J.C. Prinz.
Munich, Germany.
16.40-18.15
AMBER 3+4
W5.14.02 - PD-1 and other new molecules in the psoriatic infiltrate: an immunohistochemical and confocal laser microscopic study
Daniele Fanoni, B. Vergani, S. Recalcati, S. Tavecchio,
A.V. Marzano, A. Villa, E. Berti
Milan, Italy
W5.14.03 - Inhibition of keratinocyte differentiation
by the synergistic effect of pro-inflammatory cytokines mimics psoriasis
Aina Rabeony, I. Paris, J. Garnier, C. Barrault, N. Pedretti,
K. Guilloteau, V. Huguier, F. Bernard, J. Lecron, F. Morel
Poitiers, France
W5.14.04 - In vivo induction of cutaneous inflammation results in the accumulation extracellular trap forming neutrophils expressing RORt and IL-17, while
IL-17+ROR+ T cells remain absent
R.R.M.C. Keijsers, P.E.J. van Erp, P.C.M. van de Kerkhof,
I. Joosten, Hans J.P.M. Koenen
Nijmegen, Netherlands
W5.14.05 - Skin inflammation in Act1-deficient mice
is T cell intrinsic and due to exaggerated Th17 derived IL-22
Ling Wu, C. Wang, V.K. Kuchroo, W. Ouyang, X. Li
Cleveland, USA
W5.14.06 - Autoreactive T cells in chronic idiopathic
urticaria target the high-affinity IgE receptor I subunit (FcRI)
Priscilla Auyeung, D. Mittag, P. Hodgkin, L. Harrison
Melbourne, Australia
80
16.40-18.15
AMBER 5+6
Chairs: Giampiero Girolomoni (ITA)
Andrea Cavani (ITA)
W5.21.04 - Detection of de novo IGHV mutations by
ultra-deep sequencing from in vitro activated B cell
chronic lymphocytic leukemia cells: Evidence for activation-induced deaminase function
Charles C. Chu, P.E.M. Patten, T. MacCarthy, X.J. Yan,
J.E. Kolitz, S.L. Allen, J.C. Barrientos, K.R. Rai, N. Chiorazzi
Manhasset, USA
W5.21.05 - Early growth response gene 2 and 3 are
essential for the regulation of tumour suppressor
genes, Ikaros, Aiolos and FOXO3
Punamdip K. Bhullar, T. Miao, A.L.J. Symonds, E. Ghaffari, S. Li, P. Wang
Uxbridge, United Kingdom
W5.21.06 - CD27 signalling promotes the proliferation of human acute myeloid leukemia cells
Carsten Riether, C. Schürch, A.F. Ochsenbein
Bern, Switzerland
Workshops August 27, 2013
W1.05 - INNATE LYMPHOCYTES
W5.16.02 - A second generation therapeutic cellular
vaccine for hepatitis C virus
Branka Grubor-Bauk, P. Latour, J. Torresi, W. Yu, S. Roberts, B. Loveland, E. Gowans
Adelaide, Australia
Chair: Paolo Dellabona (ITA)
IL1.05.01 - Functional Education of iNKT Cells by Dendritic Cell Tuning of SHP-1
Paolo Dellabona, A. Napolitano, G. Casorati
Milano, Italy
W5.16.03 - Gender predominance is mediated via testosterone in a mouse model of autoimmune cholangitis
Dorothee Schwinge, A. Carambia, A. Quaas,
C. Wegscheid, G. Tiegs, A.W. Lohse, J. Herkel, C. Schramm
Hamburg, Germany
16.40-18.15
AMBER 7+8
W1.05.01 - TSLP induces corticosteroid resistance of
natural helper cell and evokes severe asthma
Kazuyo Moro, H. Kabata, K. Asano, S. Koyasu
Yokohama, Japan
W1.05.02 - Group 2 innate lymphocytes are critical for
Th2 cell-mediated allergic lung inflammation
T.Y.F. Halim, L. Matha, C.A. Steer, F. Takei, Itziar Martines
Gonzales
Vancouver, Canada
W5.16.04 - CD49a+DX5- NK cells are liver-resident and
confer adaptive immunity in skin-contact inflammation
Zhigang Tian, H. Peng, X. Jiang, Y. Chen, D. Sojka,
H. Wei, R. Sun, W. Yokoyama
Hefei, China
W1.05.03 - Identification of IL-17+RORT+CD34+ as lineage-committed progenitors of IL-22+NCR+RORT+
innate lymphoid cells
Elisa Montaldo, L.G. Teixeira, L. Moretta, M.C. Mingari,
C. Romagnani
Genoa, Italy
W5.16.05 - Phenotypic evaluation of CD28 negative
T cells in primary sclerosing cholangitis
Evaggelia Liaskou, L. Jeffery, S. Suresh, P. Trivedi, T. Bruns,
D.H. Adams, D.M. Sansom, G.M. Hirschfield
Birmingham, United Kingdom
W1.05.05 - Reduced MAIT cell frequency associated
with enhanced cell death in systemic lupus erythematosus
Asako Chiba, N. Tamura, E. Hayashi, R. Matsudaira,
T. Yamamura, Y. Takasaki, S. Miyake
Tokyo, Japan
16.40-18.15
BROWN 1
W1.05.04 - T-bet is required for the development of
NKp46+ innate lymphoid cells via a Notch-dependent
pathway
Lucille C. Rankin
Parkville, Australia
W5.16.06 - Tumor-infiltrating IL-10 producing T cells
are potent suppressors of the local anti-tumor immunity in patients with liver cancer
Alexander Pedroza-Gonzalez, J. Kwekkeboom, E. Vargas-Mendez, C. Verhoef, J. de Jonge, J.N.M. IJzermans,
H.L.A. Janssen, D. Sprengers
Rotterdam, Netherlands
W1.05.06 - The SLAM family receptor Ly9 (CD229) is
a negative regulator of marginal zone B cells response
Marta Cuenca, X. Romero, J. Sintes, P. Engel
Barcelona, Spain
W5.16 - LIVER IMMUNOLOGY
Chairs: Pietro Invernizzi (ITA)
Eli Pikarsky (ISR)
16.40-18.15
BROWN 1
IL5.16.01 - Progress in the genetics and epigenetics
of primary biliary cirrhosis
Pietro Invernizzi, M. Correnti, C. Mascheroni, A. Lleo,
F. Bernuzzi, I. Bianchi
Rozzano (MI), Italy
IL5.16.02 - Constitutive IKK Activation Promotes Hepatocellular Carcinoma via Formation of Inflammatory Micro-niches
Eli Pikarsky, S. Finkin, D. Yuan, I. Stein, K. Taniguchi,
K. Rajewsky, M. Karin, Y. Ben-Neriah, M. Heikenwalder
Jerusalem, Israel
W5.16.01 - IL-17A produced by T cells promotes
tumor growth in hepatocellular carcinoma
S. Ma, Q. Cheng, Y. Cai, Y. Wu, X. Yu, Haiyan Liu
Suzhou, China
81
Posters
Posters Session
Posters - August 23
Panel N°
P1.01 GRANULOCYTES
Session Time: Friday, August 23, 13:20 -15:00
001
P1.01.01 - A defect in granulopoiesis in perforin-deficient mice
Cassio C. Almeida, M.I.C. Gaspar-Elsas, T. Queto, B. Vieira, T. Vieira, D.M. Brito, P.P. Xavier-Elsas;
Rio de Janeiro, Brazil
002
P1.01.02 - Different anti-HSP70 antibodies detect different dynamics of intracellular HSP70 content in heat shocked human
neutrophils
Anna Boyko, O. Shustova, A. Klinkova, A. Sapozhnikov, E. Kovalenko;
Moscow, Russian Federation
003
P1.01.03 - Role of CD63, CD11b and CD14 as potential markers of granule release induced by propionate in bovine neutrophils
Rafael A. Burgos, M.D. Carretta, M.A. Hidalgo;
Valdivia, Chile
004
P1.01.04 - Photoconversion and in vivo imaging reveal a role for neutrophils in regulating adaptive immune responses
H.R. Hampton, J. Bailey, M. Tomura, R. Brink, Tatyana Chtanova;
Darlinghurst (Sydney), Australia
005
P1.01.05 - Different role of nitric oxide on adhesiveness and apoptosis of inflammatory granulocytes after burn injury
Biljana Draskovic-Pavlovic, D. Vucevic, I. Majstorovic, B. Bozic, G. Zunic, M. Colic;
Belgrade, Serbia
006
P1.01.06 - Glucocorticoid-induced leucine zipper (GILZ) promotes apoptosis in vitro in neutrophil-like cells
Marie-Alix Espinasse, P. Piednoir, G. Dufour, P. Montravers, S. Chollet-Martin, M. Pallardy, A. Biola-Vidamment;
Chatenay Malabry, France
007
P1.01.07 - In vivo induction of Neutrophil Extracellular Traps by Mycobacterium tuberculosis
Georgina Filio-Rodriguez, I. Estrada, P. Arce-Paredes, S. Islas-Trujillo, B. Moreno-Altamirano, O. Rojas-Espinosa;
Mexico City, Mexico
008
P1.01.08 - Activation of phagocytosis by a low molecular fraction (below 5 kDa) from cord blood in leukocytes after
hypothermic storage or cryopreservation
Anatoliy N. Goltsev, N.N. Moiseyeva, O.L. Gorina, J.S. Akhatova;
Kharkov, Ukraine
009
P1.01.09 - Chemerin aggravates DSS-induced colitis associated with defective protective innate responses
Rui He, Y. Lin, X. Yang, W. Yue, L. Zou, B. Li;
Shanghai, China
010
P1.01.10 - Neutrophils as potential biomarkers in the differentiation of multiple sclerosis and neuromyelitis optica
Laura Hertwig, N. Borisow, K. Stürner, B. Seeger, C. Infante Duarte, F. Paul;
Berlin, Germany
011
P1.01.11 - Kinase activity profiling of polymorphonuclear cells in critically ill patients
Arie J. Hoogendijk, G.M. Fuhler, L.A. van Vught, M.A. Wiewel, H. Belkasim, M.A.M. Huson, B.P. Scicluna, J. Horn, M.J. Schultz,
T. van der Poll;
Amsterdam, Netherlands
012
P1.01.12 - The role of neutrophils upon infection with the protozoan parasite Leishmania mexicana in C57BL/6 mice
Benjamin Hurrell, S. Schuster, J. Alexander, M. Malissen, F. Tacchini-Cottier;
Epalinges, Switzerland
013
P1.01.13 - Intercellular ROS signaling in granulocyte-mediated tumor cell destruction
Morana Jaganjac, T. Matijevic, G. Bauer, R.J. Schaur, A.A. Latiff, N. Zarkovic;
Doha, Qatar
014
P1.01.14 - Cyclophilin A stimulates recovery of the hematopoietic and the immune system of the organism after radiotherapy
Anastasia Kalinina, N. Kulikova, D. Kazansky, Y. Silaeva, L. Khromykh;
Moscow, Russian Federation
015
P1.01.15 - Effect of colchicine on expression of inflammation-related genes in neutrophils from healthy subjects
and patients with familial Mediterranean fever
Gayane Manukyan, M. Petrek, A. Martirosyan, Z. Navratilova, E. Kriegova;
Yerevan, Armenia
016
P1.01.16 - Cross-talk between neutrophils and Pseudomonas aeruginosa biofilm. Role of MPO-halide system products
Janusz Marcinkiewicz, M. Strus, M. Walczewska, E. Pasich, M. Ciszek-Lenda, A. Machul, D. Mikołajczyk;
Kraków, Poland
017
P1.01.17 - Role of 5-lypoxygenase in the regulation of eosinophilopoiesis
Daniela Masid-de-Brito, P.P. Xavier-Elsas, R.A. Luz, R. Lopes, C. Almeida-Da Silva, K. Pinnola, R. Ferreira, M.C. Gaspar-Elsas;
Rio de Janeiro, Brazil
018
P1.01.18 - The p38-MSK1 signaling cascade influences cytokine production through bZIP transcription factors in human
neutrophils
Patrick P. McDonald, T.Z. Mayer, F.A. Simard, A. Cloutier;
Sherbrooke, Canada
019
P1.01.20 - IL-4 derived from basophil play a pivotal role in cysteine protease-induced natural helper cell-mediated lung
inflammation
Yasutaka Motomura, H. Morita, K. Moro, S. Nakae, S. Koyasu, M. Kubo;
Noda, Japan
83
Posters - August 23
020
P1.01.22 - The Dectin-1 ligand Beta-glucan triggers neutrophil extracellular trap (NET) formation via a signaling pathway
requiring Src-family kinases and Syk
Giorgio Berton
Verona, Italy
021
P1.01.23 - Effects of proton pump inhibitors and H2-antagonists on neutrophil oxidative metabolism in patients with
gastric and duodenal ulcer bleeding
Natalia S. Obraztsova, O.N. Sulaieva, V.Y. Delii, S.O. Zarikov;
Donetsk, Ukraine
022
P1.01.24 - IgE-armed basophils and their skin-infiltration are essential for acquired tick resistance
Takuya Ohta, S. Yoshikawa, K. Ishiwata, K. Horiguchi, L. LI, Y. Kawano, H. Kanuka, N. Watanabe, Y. Minegishi, H. Karasuyama;
Tokyo, Japan
023
P1.01.25 - IL-17A differential effects in murine bone marrow granulopoiesis in presence of GM-CSF or IL-5 in vitro
Lysianne Pinto, T. Queto, D.M. Brito, C.L. Coutinho, B. Luca, B.M. Vieira, J.C. Alves Filho, F.Q. Cunha, M.I.C. Gaspar-Elsas, P.P. XavierElsas;
Rio de Janeiro, Brazil
024
P1.01.26 - Effect of testosterone on the activity of inflammatory cells
Amado Quintar, C. Leimgruber, N. Peinetti, C. Maldonado;
Cordoba, Argentina
025
P1.01.27 - Reveiling the death pathway leading to eosinophil cytolysis
Susanne Radonjic-Hoesli, C. Stoeckle, D. Simon, B. Styp-Rekowska, R. Hlushchuk, S. Yousefi, H. Simon;
Bern, Switzerland
026
P1.01.28 - Basophils control T cell responses and limit disease activity in Experimental Murine Colitis
Manuel Rodriguez Gomez, F. Hermann, K. Claudia, Y. Talke, I. Ketelsen, B. Reich, K. Renner, S. Syed, H. Bruehl, M. Mack;
Regensburg, Germany
027
P1.01.29 - Sympathoadrenergic modulation of human neutrophils
Angela Scanzano, L. Schembri, E. Rasini, R. Bombelli, M. Legnaro, A. Luini, M. Cosentino, F. Marino;
Varese, Italy
028
P1.01.30 - Role of neutrophils in neovessel formation in atherosclerotic lesions: preliminary evidence in patients with carotid
plaque
Laura Schembri, A. Scanzano, M. Tozzi, E. Rasini, M. Legnaro, A. Luini, M. Cosentino, F. Marino;
Varese, Italy
029
P1.01.31 - Blockage of histamine receptor 2 ameliorates the progression of sepsis in NOD diabetic mice
Gabriela T. Scortegagna, P.H. Melo, D. Nascimento, V. Borges, F.O. Souto, D. Carlos, F.Q. Cunha;
Ribeirão Preto, Brazil
030
P1.01.32 - Entry of Staphylococcal Superantigen-Like Protein 11 into neutrophils attenuating their recruitment
Richard P. Sequeira, R.J. Langley, T. Proft, J.D. Fraser;
Auckland, New Zealand
031
P1.01.33 - Effect of exercise on cytokine production by neutrophils
Irina Shvydchenko, E. Bykovskaya, V. Romenskaya, G. Rozhkova, A. Simbirtsev;
Krasnodar, Russian Federation
032
P1.01.34 - Role of nanoparticles in apoptosis and cytoskeleton rearrangement in human leukemia eosinophil like AML
14.3D10 cells
Jean-Christophe Simard, F. Vallières, D. Girard;
Laval, Canada
033
P1.01.35 - Orai1-mediated Ca2+ influx independent of SOCE is essential for LPS and C5a-induced neutrophil migration in
acute inflammation
Georgios Sogkas, T. Vögtle, B. Nieswandt, R. Schmidt, E. Gessner;
Hannover, Germany
034
P1.01.36 - Soluble molecules from Trypanosoma cruzi are able to induce NETosis from human neutrophils in the absence
of classical apoptosis and necrosis signals
L.F.A. Diniz, P.S.S. Souza, M. Thomaz-Tobias, D. Sousa-Rocha, M.F. Costa, Karina A. Toledo;
Assis, Brazil
035
P1.01.37 - Role of PI3K, PKC and ERK on neutrophil extracellular trap release induced by Leishmania amazonensis
Thiago S.S. Vieira, A. Guimarães-Costa, M.T.C. Nascimento, R. Mariante, E.M. Saraiva;
Rio de Janeiro, Brazil
036
P1.01.39 - Critical roles of DOCK2 and DOCK5 in neutrophil chemotaxis, ROS production, and NETs formation
Mayuki Watanabe, A. Nishikimi, M. Terasawa, J. Côté, Y. Fukui;
Fukuoka, Japan
037
P1.01.40 - Untouched isolation of functionally unaffected neutrophils from whole blood within 20 minutes
C. Zyntek, J. Schmitz, Gregor Winkels;
Bergisch Gladbach, Germany
84
Posters - August 23
P1.02 MAST CELLS
Session Time: Friday, August 23, 13:20 -15:00
038
P1.02.01 - Role of mast cells and histamine in local reaction induced by Potamotrygon motoro stingray venom in mice
L.F. Kimura, J.P. Prezotto-Neto, M.M. Antoniazzi, S. Jared, C.F. Teixeira, M.L. Santoro, Katia C. Barbaro;
São Paulo, Brazil
039
P1.02.02 - Cross reactivity of IL-3 between mouse and rat in the induction of mouse bone marrow derived mast cells
J. Lee, K. Shin, C. Kim, K. Joo, Sung-Weon Cho;
Seoul, Korea, Republic of
040
P1.02.03 - OX40L-STIMulated inhibition of mast cell calcium influx
Federica D’Incà, J. Almering, B. Frossi, H. Sandig, M. Freichel, S. Bulfone-Paus, C. Pucillo;
Udine, Italy
041
P1.02.04 - Augmenting the effects of vaccine adjuvants by targeting mast cells
Yu Fang, N. Lycke, Z. Xiang;
Guiyang, China
042
P1.02.05 - Generation of mast cells from murine fetus liver and transcriptome analysis using next generation sequencer;
a comparison of the profiles between bone marrow derived mast cells with fetus liver derived mast cells
Nobuyuki Fukuishi, Y. Igawa, T. Kunimi, N. Matsui, M. Akagi;
Tokushima, Japan
043
P1.02.06 - Mast cells induce invariant Natural Killer T cells to cytokine secretion and proliferation via CD1d: Another path to
asthma?
Nestor Gonzalez Roldan, S. Bulfone-Paus;
Borstel, Germany
044
P1.02.07 - Mast cell CYP27B1 hydroxylase activity is required for 25OH vitamin D3-induced suppression of IgE-mediated
activation
Michele A. Grimbaldeston, K. Yip, C. Yu, N. Kolesnikoff, H. Taing, D. Goltzman, P.H. Anderson, M. Samuel, A. Lopez;
Adelaide, South Australia, Australia
045
P1.02.08 - IgE-mediated allergic responses in human mast cells in humanized NOG mice expressing human IL-3 and GM-CSF
Ryoji Ito, T. Takahashi, I. Katano, K. Kawai, S. Nunomura, C. Ra, A. Mori, S. Aiso, M. Ito;
Kawasaki, Japan
046
P1.02.09 - Roles of basophils and mast cells infiltrating the lung in murine asthmatic responses induced by multiple antigen
challenges
Haruka Kida, A. Takiguchi, H. Wakamori, K. Ishihara, S. Akiba, N. Mizutani, S. Yoshino, D.D. Chaplin, S. Ohya, T. Nabe;
Kyoto, Japan
047
P1.02.10 - Immune suppression following exposure to UV-radiation is associated with increases in mast cell densities in
primary and secondary lymphoid tissues
Lai Fong Kok, C. Beuagie, C. Chan, S. Sarchio, G. Halliday, S. Byrne;
Sydney, Australia
048
P1.02.11 - Intravenous injection of particulate antigens larger than the intracellular gap of endothelial cells can induce
mast cell-mediated systemic anaphylaxis
Lihua Li, S. Yoshikawa, K. Horiguchi, T. Ohta, H. Deki, Y. Kawano, H. Karasuyama;
Tokyo, Japan
049
P1.02.12 - The development of oral tolerance is inhibited by TLR2 agonists but not by IgE-mediated mast cell activation
M. Tunis, I. Haidl, Jean S. Marshall;
Halifax, Canada
050
P1.02.13 - Notch1 signaling confers antigen-presenting functions on mast cells
Nobuhiro Nakano, C. Nishiyama, H. Yagita, K. Okumura, H. Ogawa;
Tokyo, Japan
051
P1.02.15 - Involvement of transcription factors PU.1, GATA1 and GATA2 in the expression and function of human
FcepsilonRI on mast cells
Chiharu Nishiyama, E. Inage, K. Kasakura, T. Yashiro, M. Hara, H. Saito, T. Shimizu, H. Ogawa, K. Okumura;
Tokyo, Japan
052
P1.02.16 - Identification of a molecule critical for degranulation of mast cells and anaphylactic reaction
Kana Ogawa, Y. Tanaka, Y. Fukui;
Fukuoka, Japan
053
P1.02.17 - C. albicans phagocytosis by mast cells via Toll like receptor-2: protection or immune escape?
Karen H. Pinke, H.G. Lima, F.Q. Cunha, V.S. Lara;
Bauru, Brazil
054
P1.02.18 - Deciphering the molecular immunobiology of anaphylactic shock - and the de novo paradigm shift
Peter N. Pushparaj, L.A. Damiati, S.D. Kumar, J. Manikandan, M.H. Al-Qahtani;
Jeddah, Saudi Arabia
055
P1.02.20 - The potential role of mast cells in the C-protein induced myositis model
Kichul Shin, J. Choi, S. Jang, Y. Song;
Seoul, Korea, Republic of
056
P1.02.21 - IgE by itself affects, directly and indirectly, mast cell effector functions
Aleksandra Słodka, E. Bąbolewska, P. Witczak, E. Brzeziłska-Błaszczyk;
Łódź, Poland
85
Posters - August 23
057
P1.02.22 - Mast cells play a crucial role in non-IgE mediated experimental allergic enteropathy
Masako Toda, M. Burggraf, H. Nakajima-Adachi, S. Hachimura, D. Dombrowicz, J. Kirberg, H. Kiyono, G. Hermann-Josef, S. Vieths;
Langen, Germany
058
P1.02.23 - Mast cells support in vitro differentiation of Th17 cells
Aurelia Walczak-Drzewiecka, M. Ratajewski, J. Dastych;
Lodz, Poland
059
P1.02.24 - Maturation of mast cells by Wnt family proteins
Tomoko Yamaguchi, K. Tashiro, H. Mizuguchi, K. Kawabata;
Osaka, Japan
P1.06 MACROPHAGES
Session Time: Friday, August 23, 13:20 -15:00
060
P1.06.01 - T cell derived IL-3 enhances the pro- and anti-inflammatory properties of human macrophages dependent of
the activation status
Ronald M. Allen, N.A. Kittan, S. Mukherjee, A. Dhaliwal, S.L. Kunkel, C.M. Hogaboam;
Ann Arbor, United States
061
P1.06.02 - Dissociation of innate immune responses in microglia infected with Listeria monocytogenes limits activation
and neuronal damage
Carmen Alvarez-Dominguez, E. Rodriguez-Del Rio, M. Lopez-Fanarraga;
Santander, Spain
062
P1.06.03 - Copper nanoparticles inhibit LPS-mediated nitric oxide and IL-12p40 production in macrophages
A. Barrientos, Sergio Arancibia;
Santiago, Chile
063
P1.06.04 - Impact of acute and chronic stress on innate immune system in elderly
Sarra Baëhl, G. Dupuis, D. Lorrain, F. Cabana, I. Viens, A. Svotelis, T. Fülöp;
Sherbrooke, Canada
064
P1.06.05 - Modulation by lipoxin of tumor-associated macrophages profile
Raphael Lourelro Simões, N.M. de Brito, I.M. Fierro
Rio de Janeiro, Brazil
065
P1.06.06 - The tyrosine kinase Abl is a component of macrophage podosomes and is required for podosome formation
and macrophage migration
A. Baruzzi, S. Remelli, Giorgio Berton;
Verona, Italy
066
P1.06.07 - Oncogene-induced senescence in histiocytes: role of BRAFV600E in the pathogenesis of Erdheim-Chester disease
Riccardo Biavasco, M. Cangi, L. Pecciarini, G. Grassini, G. Cavalli, C. Campochiaro, B. Guglielmi, M. Ferrarini, C. Doglioni, L. Dagna;
Milan, Italy
067
P1.06.08 - Jacalin drives macrophage polarization toward an anti-tumor M1-like phenotype
Gabriela S. Bisson, C.D. Polli, T.H. Geraldino, L.C. Veronez, L.P. Ruas, M.C. Roque-Barreira;
Ribeirão Preto, Brazil
068
P1.06.09 - Modulation of NKG2D and NKG2A ligands expression during monocyte differentiation
Giorgio Camilli, F. Paladini, A. Cassotta, R. La Scaleia, S. Battella, M. Fiorillo, G. Palmieri, A. Santoni, R. Sorrentino;
Rome, Italy
069
P1.06.10 - Decoy receptor 3 enhances tumor progression via induction of tumor-associated macrophages
S.K. Tai, Hsin C. Chang, K.L. Lan, C.T. Lee, C.Y. Yang, N.J. Chen, T.Y. Chou, D.C. Tarng, S.L. Hsieh;
Taipei, Taiwan
070
P1.06.11 - PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis
Hui-Hsin Chang, S. Miaw, W. Tseng, Y. Sun, C. Liu, H. Tsao, I. Ho;
Boston, United States
071
P1.06.12 - Triggering receptor expressed on myeloid cells-1 regulates macrophage polarization in an obstruction-induced
nephritis mouse model
T. Luo, K. Tseng, W. Tsao, P. Lee, S. Hsieh, A. Chiu, T. Takai, T. Mak, D. Tarng, Nien-Jung Chen;
Taipei, Taiwan
072
P1.06.13 - Polarized activation phenotypes of spontaneously differentiated human monocyte-derived macrophages: role
of dexamethasone
Andrea Cignarella, A. Toniolo, S. Tedesco, C. Bolego;
Padova, Italy
073
P1.06.14 - Influence of the phagocytizing mononuclear system (PMS) stimulation on liver and kidney regeneration
Irina Danilova, S. Medvedeva, I. Gette;
Ekaterinburg, Russian Federation
074
P1.06.15 - Modulation of macrophage function by growth hormone
Maria D. dos Santos Reis, Y.M.O. dos Santos, L.F.A. Vieira, A.R.A. Brandão, I.M.M.N. Viana, S. Smaniotto;
Rio de Janeiro, Brazil
075
P1.06.16 - The overexpression of glucocorticoid-induced leucine zipper (GILZ) protein in macrophages enhance lifetime in
mouse septic shock model
Mehdi Ellouze, F. Capel, O. Robert, A. Cassard-Doulcier, G. Perlemuter, M. Pallardy, F. Bachelerie, D. Emilie, V. Godot;
Clamart, France
86
Posters - August 23
076
P1.06.17 - CD200R-dependent regulation of monocytes is subset- and tissue specific
Mika A. Falck-Hansen;
London, United Kingdom
077
P1.06.18 - Study of aminoacidic sequences of vitamin D binding proteins involved in macrophage activation
Maria Giulia Fiore, S. Magherini, M. Gulisano, S. Pacini, M. Ruggiero;
Firenze, Italy
078
P1.06.19 - Characterization of the murine CD163 receptor
Lena Fischer-Riepe, K. Barczyk, D. Holzinger, M. Wolf, J. Roth;
Muenster, Germany
079
P1.06.20 - Effects of biodegradable polylactic acid fibers and dexamethasone on classical and alternative activation
pathways in macrophages
Mari Hämäläinen, E.L. Paukkeri, A. Pekurinen, R. Nieminen, M. Kellomäki, T.L.J. Tammela, M. Talja, E. Moilanen;
Tampere, Finland
080
P1.06.22 - Thymic cortical dendritic macrophages (TCDMs); professional scavengers of apoptotic thymocytes in the human
thymus
Atsushi Hayashi, Y. Miki, Y. Gion, K. Takahashi;
Okayama, Japan
081
P1.06.23 - Tissue macrophages arise from fetal liver monocytes during late embryonic development
Guillaume Hoeffel, J. Chen, P. See, D. Low, F. Almeida, D. Hashimoto, M. Merad, M. Poidinger, F. Ginhoux;
Singapore, Singapore
082
P1.06.24 - Fighting chronic inflammation - CD64-specific elimination of M1 macrophages
Dmitrij Hristodorov, R. Mladenov, V. von Felbert, M. Huhn, R. Fischer, S. Barth, T. Thepen;
Aachen, Germany
083
P1.06.25 - The functional fate of human monocytes after engagement of various pattern recognition receptors
Daniela C. Ifrim, J. Quintin, L.A.B. Joosten, N.A.R. Gow, D.L. Williams, J.W.M. van der Meer, M.G. Netea;
Nijmegen, Netherlands
084
P1.06.26 - Intracellular chloride channel protein CLIC1 regulates macrophage functions via modulation of phagosomal
acidification
Lele Jiang, K. Salao, H. Li, J.M. Rybicka, R.M. Yates, D.A. Brown, L.J. Brown, P.M.G. Curmi, S.N. Breit;
Sydney, Australia
085
P1.06.28 - Intestinal epithelial cell-derived Semaphorin 7A negatively regulates development of colitis via αvβ1 integrin
Sujin Kang, A. Kumanogoh;
Suita, Japan
086
P1.06.30 - The effects of silica nanoparticles in macrophage cells
SeungJae Kim, I. Choi;
Seoul, Korea, Republic of
087
P1.06.31 - Alternatively Activated Macrophages - Cause or Consequence in Allergic Airway inflammation?
Frank Kirstein, N. Nieuwenhuizen, F. Brombacher;
Cape Town, South Africa
088
P1.06.32 - MyD88 and Stat3 signaling are fundamental to tumor associated macrophage function
Franz Kratochvill, J.E. Qualls, L. Van De Velde, P. Kovarik, P.J. Murray;
Memphis, United States
089
P1.06.33 - SHP-1/Src protein complex differentially regulates IL-12 and IL-23 cytokines in TLR4-activated signaling
pathways in human macrophages
Ashok Kumar, Y. Konarski, A. Busca, M. Kozlowski;
Ottawa, Canada
090
P1.06.34 - DMXAA, a vascular disruptive agent, is a potent inhibitor of prostaglandin synthesis
Etsushi Kuroda, K. Ohata, K.J. Ishii;
Suita, Japan
091
P1.06.35 - Myeloid cell expressed proprotein convertase Furin attenuates inflammation
Zuzet Martinez Cordova, A. Oksanen, S. Hämäläinen, V. Taverniti, I. Junttila, M. Pesu;
Tampere, Finland
092
P1.06.36 - The marine natural product Honaucin A inhibits innate inflammation
Samantha Mascuch, H. Choi, F. Villa, M. Hensler, J. Olson, V. Nizet, F. Mahdi, D.G. Nagle, W. Gerwick, L. Gerwick;
La Jolla, United States
093
P1.06.37 - Differential effect of cyanobacterium Anabaena sp. lipopolysaccharide (LPS) on rat brain microglia-derived
proinflammatory and anti-inflammatory cytokines and chemokines
Alejandro M. Mayer, D. Macadam, M.L. Hall, D. Feher, P. Williams;
Downers Grove, United States
094
P1.06.38 - Pulmonary surfactant protein A strengthens IL-4-mediated proliferation and alternative activation
of rat alveolar macrophages
Carlos Minutti, B. García-Fojeda, C. Casals;
Madrid, Spain
095
P1.06.39 - Characterization of the innate immune response in human macrophages by Mycobacterium bovis BCG
Gabriela Molina-Olvera, A.I. Castllo-Rodal, Y. López-Vidal;
México, Mexico
87
Posters - August 23
096
P1.06.40 - Regulation of macrophage complement receptor immunoglobulin (CRIg) expression by cytokines
Usma Munawara, A. Quach, N.N. Gorgani, C. Abbott, A. Ferrante;
Adelaide, Australia
097
P1.06.41 - Ubiquitin-like protein MNSFβ covalently binds to Bcl-G and enhances lipopolysaccharide (LPS)/interferon γ
(IFNγ)-induced apoptosis in macrophages
Morihiko Nakamura, M. Nakagawa;
Izumo, Japan
098
P1.06.42 - T CD8+ suppressor lymphocyte-derived exosomes carrying miRNA150 impair macrophage ability to induce
humoral immune response in mice
Katarzyna Nazimek, M. Ptak, W. Ptak, K. Bryniarski;
Krakow, Poland
099
P1.06.43 - The role of MAP kinase phosphatase-2 (MKP-2) in macrophage development and gene expression
Thikryat Neamatallah, J. Schroeder, R. Tate, J. Alexander, R. Plevin;
Glasgow, United Kingdom
100
P1.06.44 - Differential regulation of innate immunity in the lungs of smokers and non-smokers
Johan Öckinger, M. Hagemann-Jensen, S. Kullberg, A. Eklund, J. Grunewald, J. Wahlström;
Stockholm, Sweden
101
P1.06.45 - Notch Signaling Regulates Expression of Mcl-1 and Apoptosis in PPD-treated Macrophages
Tanapat Palaga, S. Ratanabunyong, T. Pattarakankul, Y. Hadae, N. Sangphech, P. Kuenjinda;
Bangkok, Thailand
102
P1.06.46 - Evaluation of the potency of CD137-activated macrophages in inhibiting tumor cell growth
Wan Lu Pang, H. Schwarz;
Singapore, Singapore
103
P1.06.47 - Statins mediate protection against Mycobacterium tuberculosis infection by enhancing phagosomal maturation
and autophagy
Suraj P. Parihar, R. Guler, R. Khutlang, D. Lang, M. Mhlanga, H. Suzuki, D. Marais, F. Brombacher;
Cape Town, South Africa
104
P1.06.48 - Metalloproteinase-9 production by monocytes from cutaneous leishmaniasis patients
Sara Passos, T. Menezes, R. Costa, E.M. Carvalho, L.P. Carvalho;
Salvador, Brazil
105
P1.06.49 - The importance of experimental milieu in regulation of macrophage activation
Michaela Pekarova, A. Lojek, H. Martiskova, A. Klinke, T. Rudolph, M. Maceckova, R. Kuchta, J. Kadlec, Z. Kuchtova, L. Kubala;
Brno, Czech Republic
106
P1.06.50 - The interaction of monocytes from Sjögren Syndrome patients with human salivary gland epithelial cells
promotes an inflammatory microenvironment modulated by VIP
V. Hauk, L. Fraccaroli, E. Grasso, A. Eimon, R. Ramhorst, O. Hubscher, Claudia Perez-Leiros;
Buenos Aires, Argentina
107
P1.06.51 - Contribution of microRNAs to human macrophage polarization processes
Matthieu Pesant, G. Sukubo, M. Locati;
Rozzano, Italy
108
P1.06.53 - Altered Expression of CD200/CD200R1 Immunoinhibitory Proteins is Associated with the Dysregulated
Microglial Response to Ischemic Stroke Injury in Aged Mice
Rodney M. Ritzel, A. Patel, V. Scranton, L. McCullough, F. Liu;
Farmington, United States
109
P1.06.54 - Age-and Location-Related Changes in the Immunoregulatory Status of Microglia
Rodney M. Ritzel, A.R. Patel, F. Liu, L.D. McCullough;
Farmington, United States
110
P1.06.55 - Modulation of FcgammaRs expression in macrophages derived from THP-1 cells (THP-1-MΦ) polarized to
inflammatory, wound-healing and regulatory phenotypes
Ana Diana Rivera Fuentes, E. Ortega Soto;
Mexico, Mexico
111
P1.06.56 - Non-classical circulating monocytes are reduced in patients with systemic lupus erythematous (SLE) and they
show regulatory functions on classical monocytes in healthy controls
C. Burbano-Arciniegas, G. Vasquez-Duque, Mauricio Rojas-Lopez;
Medellín, Colombia
112
P1.06.57 - Isolation of mouse alveolar macrophage using mixed primary culture from lungs
P.M.C. Silva, I.T. Brandão, A.P. Masson, W.M. Rios, R.F. Rodrigues, C.L. Silva, Rogerio S. Rosada;
Ribeirão Preto, Brazil
113
P1.06.58 - Mac-1 controls the pro-inflammatory phenotype of type 1 macrophages
Kim C.M. Santegoets, M.H. Wenink, D.M. Lundvig, L. van Bon, A. Cambi, R.A. Benson, I. McInnes, W.B. van den Berg, F.A. Wagener,
T.R.D.J. Radstake;
Utrecht, Netherlands
114
P1.06.59 - The immunomodulatory effect of propolis and chlorhexidine on cytokine production by human monocytes
Karina B. Santiago, B.J. Conti, E.O. Cardoso, J.M. Sforcin;
Botucatu, Brazil
115
P1.06.60 - Polyporus alveolaris extract (PAE) have the ability to stimulate macrophages against tumor with unique manner
Yasutaka Sasajima, M. Kawamura, T. Aradate, A. Muraguchi, T. Katagiri;
Toyama city, Japan
88
Posters - August 23
116
P1.06.61 - Realtime analysis of monocyte migration in 3D synovial micromass tissue cultures
Clemens Scheinecker, R. Byrne, K. von Dalwigk, A. Hladik, J.S. Smolen, H. Kiener;
Wien, Austria
117
P1.06.62 - The sulfation level of glycosaminoglycans in monocytes and macrophages
Maria Schönberg, U. Obeck, J. Flemmig, J. Arnhold;
Leipzig, Germany
118
P1.06.63 - IRF8 and IRF3 cooperatively regulate rapid interferon-β induction in human blood monocytes
P. Li, J. Wong, C. Sum, Wei-Xiang Sin, K. Chin;
Singapore, Singapore
119
P1.06.64 - Resolving inflammation: M2 macrophages contribute to the resolution of postoperative ileus
Kathy Stein, M. Lysson, S. Wehner, J. Kalff;
Bonn, Germany
120
P1.06.65 - CX3CR1+ monocytes support P. gingivalis survival
Orit Steinmetz, S. Hoch, L. Eli-Berchoier, G. Nussbaum;
Jerusalem, Israel
121
P1.06.66 - Identification of RORC as regulator of polarized inflammation
Laura Strauss, G. Szebeni, S. Morlacchi, M.G. Totaro, A. Bruno, D. Noonan, A. Anselmo, S. Sangaletti, M. Colombo, A. Sica;
Rozzano (MI), Italy
122
P1.06.67 - Role of macrophages reaction in pathogenesis of duodenal ulcer bleeding
Oksana N. Sulaieva;
Donetsk, Ukraine
123
P1.06.68 - Effect of phytoestrogens on helper T cell and macrophage differentiation
Masaya Takamoto;
Matsumoto, Japan
124
P1.06.69 - Immune-modifying particles inhibit inflammatory monocyte migration to the central nervous system and
improve outcomes in experimental autoimmune encephalomyelitis
Rachael L. Terry, D.R. Getts, N.J.C. King, S.D. Miller;
Chicago, United States
125
P1.06.70 - E.coli upregulates CD39 expression in RAW264.7 macrophages
Gábor Tör , B. Koscsó, B. Csóka, L. Virág, G. Haskó;
Debrecen, Hungary
126
P1.06.71 - Pulmonary GM-CSF regulates alveolar macrophage population size and function via a reciprocal feedback
mechanism
Bruce C. Trapnell, T. Suzuki;
Cincinnati, United States
127
P1.06.72 - Effect of CCL1 depletion on the tumoricidal monocyte generation in cultures of peripheral blood monocytes
derived from patients with hepatocellular carcinoma (HCC)
A. Asai, Yusuke Tsuchimoto, H. Ohama, S. Fukunishi, Y. Tsuda, A. Fukuda, M. Kobayashi, K. Higuchi, F. Suzuki;
Takatsuki, Osaka, Japan
128
P1.06.73 - Regulation of complement receptor immunoglobulin (CRIg) expression in human macrophages by protein
kinase Cα
Kanchana Usuwanthim, Y. Ma, N.N. Gorgani, C. Hii, A. Ferrante;
Adelaide, Australia
129
P1.06.74 - Modulation of phagocytosis in Mononuclear Phagocyte Cells by IL-21: Involvement of Spleen Tyrosine Kinase
(Syk)
Francis Vallières, D. Girard;
Laval, Canada
130
P1.06.75 - Characterization of central macrophages in Anemia of Inflammation (AI): African trypanosomiasis as a model
system
Liese Vansintjan, B. Stijlemans, S. Philipsen, P.J.M. Leenen, P. De Baetselier;
Brussels, Belgium
131
P1.06.76 - The immunomodulatory activity of glycerophosphoinositols
Mariangela Vessichelli, P. Italiani, S. Mariggiò, P. Zizza, V. Evangelista, D. Boraschi, D. Corda;
napoli, Italy
132
P1.06.77 - Salmonella autophagy
Tzu-Yuan Wang, C. Chiu;
Taoyuan, Taiwan
133
P1.06.78 - Regulation of myogenesis by differentially activated macrophages during human skeletal muscle regeneration
Houda Yacoub-Youssef, M. Saclier, A. Mackey, L. Arnold, J. Chelly, R. Mounier, M. Kjaer, B. Chazaud;
Paris, France
134
P1.06.79 - The role of a novel DEAD-box protein in LPS-induced NLRP3 inflammasome activation
Chih-Hsiang Yang, S. Hsu, Y. Lai, L. Hsu;
Taipei, Taiwan
135
P1.06.80 - Necrotic cells induce CD14-/CD68+ peritoneal exudate cells to proliferate and differentiate into macrophage-like
cells
Xiaolin Yuan, X. Li, Q. Zhang, C. Zhang, D. Li;
Dalian, China
89
Posters - August 23
136
P1.06.81 - The Effect of Polyporus umbellatus(Chinese medicine)on LPS-induced Viability and Cytokine Expression in
RAW264.7 cells
Xing Zeng;
Guangzhou, China
137
P1.06.82 - Suppression of PTRF inhibits TLR4 signaling: a novel regulator of sepsis
Yijie Zheng, X. Liang, S. Wei, H. Moon, Y. Jin;
Boston, United States
P1.11 TOLL-LIKE AND PATTERN RECOGNITION RECEPTORS
Session Time: Friday, August 23, 13:20 -15:00
138
P1.11.001 - Neuinflam9/Toxo1 regulates the innate immune response after nerve injury and susceptibility to autoimmune
neuroinflammation in rat
Nada Abdelmagid, F. Al Nimer, J. Öckinger, R. Lindblom, X. Zhang, S. K. Bedri, A. Saoudi, G. Fournié, T. Olsson, M. Jagodic, F. Piehl,
M. Diez;
Stockholm, Sweden
139
P1.11.002 - The Toll-IL-1R member Tir8 modulates post-transplant kidney ischemia/reperfusion injury by inhibiting resident
leukocyte expansion
P. Cassis, Sistiana Aiello, N. Azzollini, S. Solini, G. Remuzzi, M. Noris;
Ranica, Italy
140
P1.11.003 - Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived
sepsis
Adam A. Anas, M.H.P. van Lieshout, S. Florquin, B. Hou, A.L. DeFranco, C. van t. Veer, A.F. de Vos, T. van der Poll;
Amsterdam, Netherlands
141
P1.11.004 - Activation and regulation of Toll-like receptors by infestation with Rhipicephalus sanguineus ticks
Elen Anatriello, L.C. Ribeiro, I. Bueno, M.S.L. Nascimento, L.A. Sacramento, C.J. Oliveira, J.S. da Silva, I.K.F.d. Santos, B.R. Ferreira;
University of São Paulo, Ribeirão Preto, Brazil
142
P1.11.006 - Role of TIR8/SIGIRR in regulating TLR and IL-1R like-dependent platelet activation
Achille Anselmo, C. Soldani, C. Soldani, S. Gentile, S. Gentile, M. Bacci, M. Bacci, A. Voza, A. Voza, M. Nebuloni, M. Nebuloni,
L. Mendolicchio, L. Mendolicchio, A. Mantovani, A. Mantovani, F. Riva, F. Riva, C. Garlanda, C. Garlanda;
Rozzano, Italy
143
P1.11.007 - Interaction of Bordetella pertussis filamentous hemagglutinin with human TLR2: identification of the
TLR2-binding domain
Hossein Asgarian-Omran, A. Amirzargar, S. Zeerleder, M. Mahdavi, G. van Mierlo, S. Solati, M. Jeddi-Tehrani, H. Rabbani, L. Aarden,
F. Shokri;
Tehran, Iran, Islamic Republic of
144
P1.11.008 - S100A8 and S100A9 promote hyporesponsiveness of phagocytes in polytrauma and burn patients
Judith Austermann, S. Fassl, B. Petersen, E. Faist, S. Zedler, T. Vogl, J. Roth;
Muenster, Germany
145
P1.11.009 - Extended anti-cancer immunity by liposomes coencapsulating nucleic acid TLR-ligands and antigen
Banu Bayyurt, G. Gucluler, D. Bayik, E. Alpdundar, S. Yildiz, B.H. Horuluoglu, M. Ozcan, M. Gursel, I. Gursel;
Ankara, Turkey
146
P1.11.010 - R848, a Toll-like receptor 7/8 agonist, a potential therapy for allergic rhinitis patients
Ghada Boghdadi, N. Hammad, A. Amer, S. Sammour, S. Sorour;
Zagazig, Egypt
147
P1.11.011 - TLR4-induced activation of human monocyte cell line U937 by sickle patient’s mmLDL. Possible experimental
model for atherosclerosis initial phase
Beatriz E. Brito, M.A. Duarte, E.L. Romano, M.E. Marquez, L. Baute, O. Perez-Bandez, N. Torrez;
Caracas, Venezuela, Bolivarian Republic of
148
P1.11.012 - Fungal stimulated inflammatory response of gestation associated tissues
Aled H. Bryant, R.H. Jones, N. Melo, S.E. Owens, L.B. Davies, G. Morgan, I.M. Sheldon, C.A. Thornton;
Swansea, United Kingdom
149
P1.11.013 - Triggering receptor expressed on myeloid cells (TREM)-1 and -2 in bronchoalveolar lavage fluid in pulmonary
sarcoidosis
Milan Buc, M. Suchankova, M. Bucova, E. Tibenska, E. Tedlova, J. Demian, I. Majer, H. Novosadova, M. Tedla, E. Paulovicova;
Bratislava, Slovakia
150
P1.11.014 - Increased CD4 T cell survival during in vivo OVA-LPS presentation is partly inhibited by indomethacin and
recovered by PGE2 analog
Julia C. Campopiano, J.F. Jacysyn, M. Zenteno, T.B. da Costa, K.R. Bortoluci, G.P. Amarante-Mendes;
São Paulo, Brazil
151
P1.11.015 - Optimal Immune Response Is Mediated by CD8-IFN Gamma Production and Macrophages-iNOS Expression in
trigeminal ganglia, after Interactions of Toll Like Receptors in Herpes Simplex Virus -1 (HSV-1) Infection
G.P. Zolini, G.K. Lima, N. Lucinda, M.G.A. Silva, S.R. Béla, L.R.V. Antonelli, N.L. Pessoa, B.C. Pizziolo, E.G. Kroon, Marco A. Campos;
Belo Horizonte, Brazil
152
P1.11.016 - Monocyte-produced TLR2 and TLR4 but not prolactin are involved in both, late-onset autoimmune diabetes
and type 2 diabetes development
Pavlina Cejkova, V. Slukova, I. Nemeckova, J. Broz, M. Andel, M. Cerna;
Prague 2, Czech Republic
90
Posters - August 23
153
P1.11.017 - Roles of an innate immune regulator TBK1-Associated Protein in Endolysosomes (TAPE) in the RIG-I-like
receptor and DNA sensor pathways
Kuan-Ru Chen, C. Chang, C. Huang, C. Lin, W. Lin, Y. Lo, C. Yang, A. Shiau, T. Tan, P. Ling;
Tainan, Taiwan
154
P1.11.018 - Immunostimulatory activities of CpG-oligodeoxynucleotides in zebrafish
D. Yeh, Y. Liu, Tsung-Hsien Chuang;
Miaoli County, Taiwan
155
P1.11.019 - New molecular tools to investigate LPS recognition
Roberto Cighetti, V. Calabrese, G. Damore, M. Piazza, F. Peri;
Milano, Italy
156
P1.11.020 - The Q705K genetic variant in NLRP3 leads to inflammasome hyperactivation and contributes to invasive
aspergillosis after stem cell transplantation
Cristina Cunha, C. Galosi, M. Puccetti, F. Aversa, L. Romani, A. Carvalho;
Perugia, Italy
157
P1.11.021 - The Role of TLRs in the Dogs Immunized with the Gentamicin-attenuated L. infantum Compared with Dogs
Infected with Wild-type Parasites
Maryam Davarpanah;
Kerman, Iran, Islamic Republic of
158
P1.11.022 - Unbalanced cytokine production in inducible nitric oxide synthase-deficient neonate mice upon in vitro
stimulation with TLR agonists
Cyro A. de Brito, B.S. Shida, N.Z. Pereira, A.J.S. Duarte, M.N. Sato;
Sao Paulo, Brazil
159
P1.11.023 - Myeloid-related protein (Mrp)-8/14 contributes to protective immunity in sepsis caused by Burkholderia
pseudomallei and elevated levels correlate with poor outcome
Hanna K. de Jong, T.A.F. Weehuijzen, A. Achouiti, L.M. Kager, G.C.K.W. Koh, J. Roth, T. Vogl, T. van der Poll, W.J. Wiersinga;
Amsterdam, Netherlands
160
P1.11.024 - Response of human monocyte-derived dendritic cells to the combined effect of TLR3 and TLR7 agonists
Tanja Dzopalic, A. Dragicevic, B. Bozic, I. Rajkovic, M. Colic;
Nis, Serbia
161
P1.11.025 - Association of TLR4-D299G polymorphism with inflammation and overexpression of TLR4-CD14 in obese mexican
patients
C.O. De Loera-Rodriguez, J.E. Segura-Ortega, V. Delgado-Rizo, A. Alvarado-Navarro, Mary Fafutis-Morris;
Guadalajara, Mexico
162
P1.11.026 - Potential role of tlr ligand in aethiopathogenesis of Tunisian endemic pemphigus foliaceus
O. Abida, Raouia Fakhfakh, D. Bouzid, S. Krichen-Makni, N. Kharrat, A. Masmoudi, M. Abdelmoula, M. Ben Ayed, H. Turki,
T. Sellami-Boudawara;
Sfax, Tunisia
163
P1.11.027 - The C-type lectin receptors on dendritic cells participate in the recognition and modulatory effect of high
molecular weight components of Ascaris suum extract
B.C. Favoretto, P.A. Ranéia, J.A. Portes-Junior, J.F. Jacysyn, Eliana L. Faquim-Mauro;
São Paulo, Brazil
164
P1.11.028 - Isolation and characterization of N-linked glycan structures from high molecular weight components of
Ascaris suum extract
Bruna C. Favoretto, J.F. Jacysyn, A. Casabuono, A.S. Couto, E.L. Faquim-Mauro;
São Paulo, Brazil
165
P1.11.029 - Involvement of the nucleic acid recognizing Toll-like receptors TLR7 and TLR9 in the pathogenesis of erosive
arthritis
Anita Fischer, C. Böhm, S. Herman, V. Saferding, E. Goncalves-Alves, M. Koenders, W. van den Berg, G. Steiner;
Vienna, Austria
166
P1.11.030 - Training modifies the innate immune response both in the airways and in blood in horses
Linda Frellstedt, P. Gosset, C. Desmet, D. Pirottin, F. Bureau, I. Waldschmidt, M. Dupuis-Tricaud, P. Lekeux, T. Art;
Liege, Belgium
167
P1.11.031 - The novel TLR7 agonist GS-9620 induces a diverse set of interferon stimulated genes
Christian Frey, A. Palazzo, J. Hesselgesser, T. Cihlar, S. Pflanz;
Foster City, United States
168
P1.11.032 - NOD-like receptor activation stimulates osteoclasts
Sandra Y. Fukada Alves, M.R.F. Holanda, T.M. Taira, F.Q. Cunha;
Ribeirão Preto, Brazil
169
P1.11.033 - Collapse of TLR7/TLR9 balance leads genetical background dependent phenotypes
Ryutaro Fukui, K. Miyake;
Minato-ku, Tokyo, Japan
170
P1.11.034 - Toll-like receptors 2, 4 and CD14 gene polymorphisms in Tunisian kidney transplantation
Yousr Gorgi, H. Krichen, Y. Mechiri, I. Sfar, T. Dhaouadi, R. Bardi, M. Bacha, R. Kheder, E. Abderrahim, T. Ben Abdallah;
Tunis, Tunisia
171
P1.11.035 - Polymorphisms of Toll-like receptor 4 and CD14 genes in systemic lupus erythematosus and rheumatoid arthritis
Yousr Gorgi, T. Dhaouadi, Y. Haouami, I. Sfar, L. Abdelmoula, S. Turki, L. Ben Hassine, R. Zouari, N. Khalfallah, T. Ben Abdallah;
Tunis, Tunisia
91
Posters - August 23
172
P1.11.036 - D type CpG oligonucleotide loaded EG-7 exosomes act as strong vaccine adjuvant and anti-cancer agent
Gozde Gucluler, T. Kahraman, D. Bayik, A. Gursel, M. Gursel, I. Gursel;
Ankara, Turkey
173
P1.11.037 - CpG Oligodeoxynucleotide/cationic peptide nanorings as immunotherapeutic agents
Bilgi Gungor, F.C. Ya cı, I. Gursel, M. Gursel;
Ankara, Turkey
174
P1.11.038 - Mechanisms of MyD88- and TRIF-dependent downregulation of the glucocorticoid induced leucine zipper
(GILZ) in macrophages - mRNA destabilization vs. microRNAs
Nina Hachenthal, T. Stadter, P. Leidinger, F. Grässer, E. Meese, S. Bruscoli, C. Riccardi, A.K. Kiemer, J. Hoppstädter;
Saarbruecken, Germany
175
P1.11.039 - Expression Analysis of Molecular Markers of Inflammation in Human Monocytic THP-1 cells Cultured with
Single Walled Carbon Nanotubes Functionalized with Polyethylene Glycol (PEG-SWNT)
Alireza Haghparast, M. Heidari Kharaji, M. Moghaddam Matin, A. Ahmadpour;
Mashhad, Iran, Islamic Republic of
176
P1.11.040 - Characterization of antibody responses to M13 phage vaccine: MyD88-dependent and T-cell independent IgG
subclass responses
Shuhei Hashiguchi, M. Toyonaga, Y. Shoji, T. Gotanda, K. Sugimura;
Kagoshima, Japan
177
P1.11.041 - Card9 is essential for the CEACAM3 mediated Moraxella catarrhalis induced NF-kappaB activation in human
granulocytes
A. Heinrich, Kerstin A. Heyl, M.M. Müller, S. Bachmann, H. Slevogt;
Jena, Germany
178
P1.11.042 - Immune complexes isolated from malaria patients activate TLR9 and promote caspase-1 activation
Isabella Hirako, C. Gallego, H. Gravina, M. Ataíde, D. Pereira, B. Diamond, L.R. Antonelli, D.T. Golenbock, R.T. Gazzinelli;
Belo Horizonte, Brazil
179
P1.11.043 - Identification of novel innate pattern recognition receptors for mycobacterium tuberculosis
Ei’ichi Iizasa, T. Myamoto, T. Uematsu, T. Ishikawa, S. Yamasaki, G. Matsuzaki, H. Yoshida, H. Hara;
Saga, Japan
180
P1.11.044 - Regulation of autoimmune responses by the innate immune system in response to bacterial infections
Jincy M. Issac, Y. Mohammed, H.T. Nasser, M. Rabah, M.J. Fernandez-Cabezudo, W. Conca, B.K. al-Ramadi;
Al Ain, United Arab Emirates
181
P1.11.045 - The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract
infection
Sebastien Jaillon, F. Moalli, B. Ragnarsdottir, E. Bonavita, M. Nebuloni, A. Markotic, A. Montanelli, C. Svanborg, C. Garlanda, A.
Mantovani;
Rozzano, Italy
182
P1.11.046 - ER stress sensitizes TLR signaling and desensitizes LPS tolerance through IRE1 -mediated activation of GSK-3β
S. Kim, Yeonsoo Joe, J. Shin, S. Ryter, H. Chung;
Ulsan, Korea, Republic of
183
P1.11.047 - Investigation of kinase and inflammatory pathway modulation by I2PP2A inhibition in Prostate Cancer
Progression
Carol Johnson, F.J. Giles, F.J. Sullivan, M. Vitek, S.A. Glynn;
Galway, Ireland
184
P1.11.048 - Toll-like receptor (TLR)-4 and Hepatitis C Virus (HCV): a systematic review
Nazanin A. Kazemi Sefat, G.E. Kazemi Sefat, S. Talebi;
Kerman, Iran, Islamic Republic of
185
P1.11.049 - TLR-signaling induces Type I interferon responses in microglia and astrocytes and regulates leukocyte
infiltration to the CNS
Reza M.H. Khorooshi, T. Holm, C. Tue Berg, R. Truong Dieu, D. Dræby, S. Lienenklaus, T. Owens;
Odense, Denmark
186
P1.11.050 - A reticulon family protein Nogo is an active component of TLR-triggered innate immune responses in
macrophages
Toshifumi Kimura, M. Inui, T. Takai;
Sendai, Japan
187
P1.11.051 - Analysis of the B cell responsiveness to the TLR9 agonist CPG in malaria semi-immune versus malaria naïve
individuals
Younoussou Kone, K. Kassoum, A. Ongoiba, D. Safiatou N, D. Didier, M. Jacqueline, S. Portugal, P. Susan K., D. Ogobara K., C. Peter D.;
Bamako, Mali
188
P1.11.052 - TLR9-mediated synergistic T-bet expression and its implication for antibody production
Dorottya Kovesdi, G. Sarmay;
Budapest, Hungary
189
P1.11.053 - RIG-I dependent cross-priming of CD8+ T-cells
M. Bscheider, Diana Kreppel, J. Fischer, T. Franz, U. Kalinke, J. Ruland, C. Peschel, T. Haas, H. Poeck;
Munich, Germany
190
P1.11.054 - Some features of cellular immunity in patients with chronic spontaneous urticaria inducing reactivation of
chronic EBV infection
E.A. Sorokina, N.K. Akhmatova, E.A. Akhmatov, Olga V. Lebedinskaya;
Perm, Russian Federation
92
Posters - August 23
191
P1.11.055 - Influence of the PAMPs of opportunistic microorganisms on the TLRs expression
N.P. Utkina, E.A. Akhmatov, E.A. Ilinykh, E.V. Sorokina, E.A. Lebedinskaya, E.C. Marakasova, Olga V. Lebedinskaya, E.A. Kurbatova,
N.K. Akhmatova;
Perm, Russian Federation
192
P1.11.056 - Myeloid differentiation protein 2 as the target of curcumin analog in the inhibition of endotoxin LPS-induced
TLR-4 activity
Guang Liang, Y. Wang, L. Jiang, X. Shan;
Wenzhou, China
193
P1.11.057 - Immunomodulatory effects of P-MAPA on TLR2, ROS and nitric oxide of blood mononuclear cells from canine
with visceral leishmaniasis
Valéria M. Lima, L.M. Melo, L.d. Sanches, J. Perosso, K.L.O. Silva;
Araçatuba, Brazil
194
P1.11.058 - Dendritic cells differentiated using GM-CSF/IL-4 or FLT3L respond differently to TLR ligand maturation signals,
affecting the quality of the primed CD8+ T-cell response
Anna Lissina, O. Briceno, E. Martinuzzi, E. Gostick, D.A. Price, R. Mallone, V. Appay;
Paris, France
195
P1.11.059 - Synergy in cytokine production induced by combinatorial TLR activation
Qian Liu, J. Ding;
Singapore, Singapore
196
P1.11.060 - The cationic lipid diC14-amidine and bacterial lipopolysaccharides both activate Toll-like receptor 4 pathways
via different binding regions of TLR4
Caroline Lonez, K. Irvine, M. Gangloff, B. Caroyez, J. Ruysschaert, M. Vandenbranden, C.E. Bryant;
Cambridge, United Kingdom
197
P1.11.061 - Dectin-1 induces efficient T cell immunity and prominent expansion of CD8+ IL-17+ cells in a pulmonary model
of fungal infection
Flávio V. Loures, V.L.G. Calich;
São Paulo, Brazil
198
P1.11.062 - MSK1 and 2 inhibit LPS induced prostaglandin production via an IL-10 feedback loop
Kirsty F. MacKenzie, M.M.W. van den Bosch, S. Naqvi, S.E. Elcombe, V.A. McGuire, A.D. Reith, P.J. Blackshear, J.L.E. Dean, S.C.
Arthur;
Dundee, United Kingdom
199
P1.11.063 - Functions of endogenous TLR4 ligands
Yoshiro Maru;
Tokyo, Japan
200
P1.11.064 - Similarities and differences of innate immune responses elicited by smooth and rough LPS
Roberta Marzi, I. Zanoni, A. Broggi, R. Ostuni, M. Caccia, M. Collini, A. Venkatesh, R. Spreafico, G. Capuano, F. Granucci;
Milano, Italy
201
P1.11.065 - Multi-step regulation of STAT1 phosphorylation in response to double-stranded RNA
Tomoh Matsumiya, J. Dempoya, F. Xing, R. Hayakari, H. Yoshida, T. Imaizumi;
Hirosaki, Japan
202
P1.11.066 - Hepatic TDO2-derived L-kynurenine controls acute inflammatory responses by engaging the Aryl hydrocarbon
Receptor
Giada Mondanelli, M. Gargaro, A. Bessede, D. Matino, M. Pallotta, C. Vacca, H. Funakoshi, U. Grohmann, P. Puccetti, F. Fallarino;
Perugia, Italy
203
P1.11.067 - Expression of TLR2, 3, 9, MYD88 and TRIF in Kawasaki patients before and after IVIG therapy
Hamid R. Mortazavi, S. Aleyasin, M. Babaei, R. Amin, M.H. Karimi;
Shiraz, Iran, Islamic Republic of
204
P1.11.068 - CpG ODN ligation of TLR-9 stimulates IFN- and antinuclear antibody production in SLE patients
Sahar Morteza Gholi, Z. Babaloo, P. Rahimzadeh, M. Ghayedi, H. Namdari, F. Gharibdoost, M. Taghadosi, E. Salehi;
Tabriz, Iran, Islamic Republic of
205
P1.11.069 - Genetic polymorphisms in host innate immune sensor genes and the risk of Nasopharyngeal carcinoma in
North Africa
Khalid Moumad, J. Lascorz, M. Bevier, M. Khyatti, M. Ennaji, S. Huhn, S. Lu, L. Chouchane, M. Corbex, A. Försti;
Heidelberg, Germany
206
P1.11.070 - The self-perpetuating mechanism of antiphospholipid antibody production depends on TLR7 activation and
endosomal superoxide generation
Nadine Müller-Calleja, P. Stein, A. Canisius, C. Orning, M. Radsak, K.J. Lackner;
Mainz, Germany
207
P1.11.071 - Dual regulation of osteopontin production by TLR stimulation in dendritic cells
Tiziana Musso, S. Scutera, V. Salvi, S. Rossi, M. Alessandria, D. Bosisio, S. Sozzani;
Torino, Italy
208
P1.11.072 - Toll-like receptor genetic polymorphism influences susceptibility and severity to tuberculosis in the Indian Population
Neelam Najmi, G. Kaur, S. Sharma, R. Mehra, N. Mehra;
New Delhi, India
209
P1.11.073 - Association study between Toll-like receptor 4 single-nucleotide polymorphisms and bipolar disorder
José Oliveira, W. Boukouaci, M. Bennabi, A. Dargél, B. Etain, C. Henry, F. Bellivier, J. Kahn, M. Leboyer, R. Tamouza;
Créteil, France
93
Posters - August 23
210
P1.11.074 - Schistosome-activated B cell surface toll-like receptor-4 expression correlates with CD23 and IgM expression
Daniel O. Onguru, A.V.O. Ofulla, L. Ganley-Leal, P.N. Mwinzi;
Kisumu, Kenya
211
P1.11.075 - Toll-like receptor -2, -4 and -9 genetic variants in Mexican patients with amoebic liver abscess
Oswaldo Partida-Rodriguez, E.G. Hernandez, C. Maldonado, U. Magaña, O. Valenzuela, M.E. Nieves-Ramirez, E. Gonzalez,
A. Valadez, P. Moran, C. Ximenez;
Mexico City, Mexico
212
P1.11.076 - The role of Damage Associated Molecular Patterns (DAMPs) in the genetic susceptibility towards cigarette
smoke induced neutrophilic airway inflammation
Simon D. Pouwels, I.H. Heijink, L.E. Den Boef, M.H. Boezen, M.C. Nawijn, A.J.M. van Oosterhout;
Groningen, Netherlands
213
P1.11.077 - Friends of our enemy are our enemy: Bacteria modulate cancerous behavior of prostate cancer cell lines via TLR
signaling
Simin Rezania, N. Rashidi, O. Zarei, A. Kalantari, A. Zarnani;
Graz, Austria
214
P1.11.078 - Using recombinant lactococci constructs as a molecular tool to dissect the immunomodulating capacity of
surface piliation in Lactobacillus rhamnosus GG
I. von Ossowski, T.E. Pietilä, Johanna Rintahaka, E. Nummenmaa, V. Mäkinen, J. Reunanen, R. Satokari, W.M. de Vos, I. Palva, A. Palva;
Helsinki, Finland
215
P1.11.079 - LPR mice with TIR8 deficiency are prone to develop B-cell lymphomas
Federica Riva, M. Ponzoni, S. Bertilaccio, N. Polentarutti, A. Anselmo, A. Innocenzi, F. Caligaris-Cappio, A. Mantovani, M. Muzio,
C. Garlanda;
Milano, Italy
216
P1.11.080 - Vav proteins mediate Syk-coupled C-type lectin receptor-induced innate immunity
Susanne Roth, H. Bergmann, K. Neumann, V. Laux, C. Prazeres da Costa, V.L. Tybulewicz, X. Bustelo, J. Ruland;
Munich, Germany
217
P1.11.081 - Cigarette smoke modulates the oral epithelial cell innate immunity
Mahmoud Rouabhia, A. Semlali, M. Alanazi, J. Chakir;
Quebec, Canada
218
P1.11.082 - The role of NF-κB oscillation in inflammatory responses to Salmonella infection
Jiro Sakai, J. Wright, C.E. Bryant;
Cambridge, United Kingdom
219
P1.11.083 - Characterization of SSc5D, a molecule of the Scavenger Receptor Cysteine-Rich Superfamily, as an innate immune
receptor
Rita Santos, C. Bessa-Pereira, C.M. Gonçalves, A.M. Carmo;
Porto, Portugal
220
P1.11.084 - Essential role of IRF3 in microbiota-contributed Tslp induction and protection against intestinal inflammation
Hana Sarashina, H. Negishi, S. Miki, T. Taniguchi;
Tokyo, Japan
221
P1.11.085 - Investigating the deregulation of Toll-like receptors, pro-inflammatory cytokines and cationic peptides
(Human Beta Defensins) in normal and colon cancer tissue
Abdelhabib Semlali, A. AL Amri, H. Saeed, A. Aljebreen, O. Alharbi, M. Almadi, N. Ali Azzam, N. Reddy.P, M. Arafah, M. Rouabhia,
M. Al-Anazi;
Riyadh, Saudi Arabia
222
P1.11.086 - Investigating the expression of Toll-like receptor-2,4 and 6 in normal and ovarian cancer tissue
Y. Al-Anazi1, M. Al-Anazi, M. Al-Mutairi, M. Adar, M. Arafah, A. Warsy, S. Al-Daihan, M. Rouabhia, Abdelhabib Semlali;
Riyadh, Saudi Arabia
223
P1.11.087 - Proteolytic cleavage of human Toll-like receptor 3 by lysosomal proteases is required for receptor activation
Jin-Won Seo, E. Yang, I. Choi;
Seoul, Korea, Republic of
224
P1.11.088 - TLR7 signalling in macrophages activates IRF3 and is dependent on the adaptor TRAM
Enda Shevlin, S.M. Miggin;
Kildare, Ireland
225
P1.11.089 - Inverse Correlation between Histamine Receptor Expression and Toll-like Receptor Activation in Peripheral
Blood Mononuclear Cells from Inflammatory Bowel Disease Patients
Sylwia Smolinska, P. Konieczna, T. Lukienczuk, R. Olewinski, G. Nowak, M. Jutel, L. O’Mahony;
Wroclaw, Poland
226
P1.11.090 - Plasmacytoid dendritic cells play a key role in tumor progression in LPS-stimulated lung tumor-bearing mice
Rosalinda Sorrentino;
Fisciano, Italy
227
P1.11.091 - Pam3CSK4, a TLR2 agonist, induces in vitro osteoclastogenesis RANKL-independently and resorbs calvarial and
alveolar bone in vivo
Keiko Suzuki, T. Arimoto, T. Morohashi, N. Sakai, A. Karakawa, H. Shinoda, S. Yamada;
Tokyo, Japan
228
P1.11.092 - TLR3 recognizes single-stranded RNA with incomplete stem structures
Megumi Tatematsu, F. Nishikawa, T. Seya, M. Matsumoto;
Sapporo, Japan
94
Posters - August 23
229
P1.11.093 - Studies on the full-length human NOD-like receptor family CARD domain containing 5 (NLRC5) protein
J.A. Mótyán, A. Varga, D. Varga, K. Matúz, S. Benk , József Tőzsér;
Debrecen, Hungary
230
P1.11.094 - Activation of innate immunity through the CARD9 pathway is involved in severe influenza pneumonia
Takayuki Uematsu, E. Iizasa, N. Kobayashi, H. Yoshida, H. Hara;
Kitamoto City, Saitama, Japan
231
P1.11.095 - TLR3 as an Exacerbating Factor for Radiation-Induced Gastrointestinal Syndrome
Satoshi Uematsu, N. Takemura, S. Akira;
Minato-ku, Tokyo, Japan
232
P1.11.096 - AGE-BSA induces self- and cross-tolerance in the monocytic Mono Mac 6 cell line
Florian Uhle, I. Magel, M.A. Weigand;
Giessen, Germany
233
P1.11.097 - Role of the TLR7, 8 and 9 polymorphisms in the susceptibility to HIV-1 infection in southern Brazilian patients
Jacqueline Valverde, B. dos Santos, V. Mattevi, R. Lazzaretti, E. Sprinz, R. Kuhmmer, J. Chies;
Porto Alegre, Brazil
234
P1.11.098 - TLR9 enhances bacterial clearance and limits lung consolidation in murine MRSA pneumonia
Anne J. van der Meer, A. Achouiti, S.S. Zeerleder, A.F. de Vos, T. van der Poll;
Amsterdam, Netherlands
235
P1.11.099 - A TLR9/TRIF pathway induces tolerance via TGF-β and tryptophan catabolism in plasmacytoid dendritic cells
Gloria Castellano Gonzalez, F. Fallarino, U. Grohmann, P. Puccetti;
Perugia, Italy
236
P1.11.100 - Mannan-binding lectin inhibits Candida albicans-induced cellular responses of human THP-1 cells through
toll-like receptor 2 and toll-like receptor 4
Mingyong Wang;
Xinxiang, China
237
P1.11.101 - Rab7 GTPase negatively regulate inflammatory cytokine and type I interferon expression in LPS-stimulated
macrophages via GTP-binding dependent manner
Yuzhen Wang, J. Xie, X. Yun, W. Zhang, S. Dong, Y. Zheng, Y. Wan, J. Liu, P. Gong, S. Zhao, H. Kang;
Hohhot, China
238
P1.11.102 - Both Toll-like receptor-2 and -4 contribute to signalling of Burkholderia pseudomallei’s lipopolysaccharide
W. Joost Wiersinga, T. van der Vaart, L. Kager, S. Ngugi, J. Prior, T. van der Poll;
Amsterdam, Netherlands
239
P1.11.103 - Toll-like receptor-5 contributes to protective immunity in Gram-negative sepsis caused by Burkholderia
pseudomallei, independent of flagella presence
W. Joost Wiersinga, M. van Lieshout, J. Roelofs, T. Schuijt, T. van der Poll;
Amsterdam, Netherlands
240
P1.11.104 - A comparison of Pattern Recognition Receptor requirement for human and horse strains of Streptococcus
pneumoniae
Hannah Williams, G. Paterson, C. Bryant;
Cambridge, United Kingdom
241
P1.11.105 - Molecular mechanisms regulating the synergism between IL-32γ and NOD ligands for the induction of
adhesion molecules, cytokines and chemokines of eosinophils in allergic inflammation
C K. Wong, J. Dong, C.W.K. Lam;
Shatin, NT, Hong Kong
242
P1.11.106 - Up-regualtion of HuR was critical for TLR9 signaling induced repression of tumor suppressor miR-7 in human
lung cancer cells
Y. Li, Z. Liao, S. Zhu, Y. Hu, C. Chen, J. Luo, Lin Xu;
Zunyi, China
243
P1.11.107 - Choreography and molecular strategy of dendritic cell-mediated NK cell activation in lipopolysaccharide-mediated inflammatory conditions
Ivan Zanoni, R. Spreafico, C. Bodio, M. Di Gioia, C. Cigni, A. Broggi, T. Gorletta, M.P. Colombo, N. Garbi, F. Granucci;
Milan, Italy
244
P1.11.108 - Lithium attenuates IFN-β production and antiviral response via inhibition of TBK1/IKK-ε kinase activity
Wei Zhao, L. Wang, L. Zhang, C. Gao;
Jinan, China
245
P1.11.109 - Mutated class II transactivator activates the IL-33-upregulated Th2 differentiation via the Nod2-involved NLR
signal pathway
Z.Q. Yang, P. Gu, Z.Q. Li, Y. Zhou, L.M. Lu, G- Y. Zhou;
Shanghai, China
246
P1.11.110 - Involvement of toll like receptor 2/3/4 and 9 polymorphisms in the occurrence of cervical cancer in Tunisian
women
Sabrina ZIDI, H. Verdi, Y. Yilmaz-Yalcin, Y. Suer, E. Gazouani, A. Mezlini, F. Atac, B. Yacoubli-Loueslati;
Manar I tunis, Tunisia
95
Posters - August 23
P1.13 FC AND FC-LIKE RECEPTORS
Session Time: Friday, August 23, 13:20 -15:00
247
P1.13.01 - CD16 aggregation induced by therapeutic antibody-opsonised targets impairs cytotoxic responses in human NK
cells
Cristina Capuano, M. Romanelli, C. Pighi, R. Molfetta, R. Paolini, A. Santoni, R. Galandrini;
Rome, Italy
248
P1.13.02 - Streptococcus pneumoniae triggers platelet activation and platelet-leukocyte complex formation in a strain
dependent and Toll-like receptor 2 independent manner
Sacha F. de Stoppelaar, M.C.L. Schaap, T. van der Poll, R. Nieuwland, C. van ‘t Veer;
Amsterdam, Netherlands
249
P1.13.03 - Association of FCRL3 genotypes with susceptibility of Iranian patients to rheumatoid arthritis
Hossein Golmoghaddam, Z. Amirghofran, E. Aflaki, E. Kamali-Sarvestani, M. Shabani, Z. Esmaeilbeig, M. Rajabi;
Shiraz, Iran, Islamic Republic of
250
P1.13.04 - Fca/mR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock
Shin-ichiro Honda, K. Satoh, Y. Matsuoka, T. Matsushita, M. Fujimoto, A. Shibuya;
Tsukuba city, Japan
251
P1.13.05 - Association of FCγRIIA(CD32) polymorphism with susceptibility to brucellosis
Zahra Hosseini Khah, A. Rafiei;
Sari, Iran, Islamic Republic of
252
P1.13.06 - The role of Prohibitin (PHB) in the initial reaction of the IgE Fc receptor signal from lipid raft
Takahiro Ichii, T. Aradate, Y. Mitsuhashi, M. Hachiya, N. Tani, Y. Yamanoi, M. Kanamori, A. Muraguchi, T. Katagiri;
Toyama city, Japan
253
P1.13.07 - Engagement of the IgM Fc receptor (FcµR) with its ligand occurs in cis rather than trans
K. Honjo, Y. Kubagawa, J.F. Kearney, Hiromi Kubagawa;
Birmingham, United States
254
P1.13.08 - Selective immunotherapy of lupus prone mice by biologically active peptides and simultaneous engagement of
BCR and inhibitory B-cell receptors
Nikolina M. Mihaylova, K. Nikolova-Ganeva, M. Nikolova, T. Todorov, A. Tchorbanov;
Sofia, Bulgaria
255
P1.13.09 - FcγRIIa (CD32) polymorphism and anti-malarial IgG subclass pattern among Fulani and sympatric ethnic groups
living in eastern Sudan
Amre Nasr, N.C. Iriemenam, H.A. Giha, H.A. Balogun, R.F. Anders, M. Troye-Blomberg, G. ElGhazali, K. Berzins;
Khartoum, Sudan
256
P1.13.10 - Greater number of activated T cells and enlarged germinal centers in the spleen of bovine FcRn transgenic mice
in the background of the enhanced immune response
Zita Schneider, A. Végh, J. Cervenak, P. Balogh, I. Kacskovics;
Budapest, Hungary
257
P1.13.11 - Intravenous immunoglobulin treatment suppresses dendritic cell function in humans by stimulation of the
IL-33-Th2 pathway
Rogier van Gent, A.S.W. Tjon, H. Jadaar, M. van Hagen, L.J.W. van der Laan, P.A.W. te Boekhorst, H.J. Metselaar, J. Kwekkeboom;
Rotterdam, Netherlands
258
P1.13.12 - FcgammaRIIA and FcgammaRIIIB polymorphisms in Brazilian systemic lupus erythematosus patients and
associations with clinical manifestations
Cleni Mara Marzocchi-Machado, J.E.T. Toller-Kawahisa, J.A.T. Pancoto, C.T. Mendes-Junior, E.Z. Martinez, E.A. Donadi, P. LouzadaJúnior, J.E.C. Del Lama;
Ribeirão Preto, Brazil
P1.17 ALLERGIC MEDIATORS
Session Time: Friday, August 23, 13:20 -15:00
259
P1.17.01 - Parvalbumin: as a fish-allergen
Syed H. Arif;
Jazan, Saudi Arabia
260
P1.17.02 - Clock genes and eosinophil-specific mediators are expressed in a circadian manner in human eosinophils
Anja Baumann, O. Froy, S.C. Bischoff, A. Lorentz;
Stuttgart, Germany
261
P1.17.04 - Regulation of allergen-specific IgA and IL-17 responses by intestinal epithelial cell IKKβ reshapes allergic
inflammation at distant sites
A. Bonnegarde-Bernard, J. Jee, M.J. Fial, F. Aeffner, E. Cormet-Boyaka, I.C. Davis, M. Lin, D. Tomé, M. Karin, Prosper N. Boyaka;
Columbus, United States
262
P1.17.05 - Regulation of human skin mast cell histamine release by PDE inhibitors
Nahid Eskandari, R. Bastan, P. Peachell;
Isfahan, Iran, Islamic Republic of
263
P1.17.06 - Interferon-α antagonizes IL-3-mediated immunoregulatory functions of human basophils
Björn Hagmann, A. Odermatt, A. Eggel, C.A. Dahinden, M. Fux;
Bern, Switzerland
96
Posters - August 23
264
P1.17.07 - Serum IgE and Eosinophil level in patients Infected with giardiasis
Morteza Hosseinzadeh, A. Khosravi, E. Sabbagh, K. Sayemiri;
Tehran, Iran, Islamic Republic of
265
P1.17.08 - Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation
Fumitaka Kamachi, M. Hara, N. Harada, Y. Katsura, Y. Kojima, K. Izawa, C. Nishiyama, K. Okumura, H. Akiba;
Tokyo, Japan
266
P1.17.09 - Role of IL-6 in the development of dendritic cell-induced allergic inflammation
Yen-Lin Lin, J. Wang;
Tainan, Taiwan
267
P1.17.10 - Role of the CC-chemokine receptor CCR9 as a modulator of the inflammatory process during allergic airway inflammation
Cynthia P. Lopez-Pacheco, G. Du Pont, G. Soldevila, E.A. García-Zepeda;
Mexico, Mexico
268
P1.17.11 - Multiplex immunoassay for allergens using oligonucleotide tethering
Robert S. Matson;
Irvine, United States
269
P1.17.12 - Microfibrillar-associated protein 4 deficiency attenuates experimental allergic airway inflammation
Bartosz Pilecki, A.T. Holm, A. Schlosser, H. Wulf-Johansson, J.B. Møller, J. Vestbo, C. Stevenson, U. Holmskov, G.L. Sorensen;
Odense, Denmark
270
P1.17.13 - S1P/SphK signalling in mast cells: relevance to airway inflammation, asthma and anaphylaxis
Peter N. Pushparaj, J. Manikandan, S.D. Kumar, L.A. Damiati, K. Gauthaman, M.H. Al-Qahtani;
Jeddah, Saudi Arabia
271
P1.17.14 - Identification of a novel quantitative trait locus and candidate genes for airway hyperresponsiveness
C. Kanagaratham, R. Marino, P. Camateros, R. Sladek, S. Vidal, Danuta Radzioch;
Montreal, Canada
272
P1.17.15 - Circulating human basophils lack the features of professional antigen presenting cells
Meenu Sharma, P. Hegde, V. Aimanianda, R. Beau, H. Sénéchal, P. Poncet, S.V. Kaveri, J. Bayry;
Paris, France
273
P1.17.16 - Intratracheally administration Asian sand dust activates NF-kappaB in immune cells
Yuan Song, T. Ichinose, T. Kanazawa, Y. Yoshida;
Kitakyushu, Japan
274
P1.17.17 - Receptor for advanced glycation end products (RAGE) - a central mediator of allergic sensitization
Md. A. Ullah, Z. Loh, W.J. Gan, V. Zhang, J.M. Hughes, C.L. Armour, S. Phipps, M.B. Sukkar;
Sydney, Australia
P2.01 LEUKOCYTE SIGNALLING
Session Time: Friday, August 23, 13:20 -15:00
275
P2.01.01 - Hydrophobic amino acid cluster in the cytoplasmic tail of interleukin-2 receptor β chain acts as a sorting signal
for lysosome
Yuji Amano, K. Kojima, K. Yoshino, T. Takeshita;
Matsumoto, Nagano, Japan
276
P2.01.02 - Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal
transduction through ERK1/2 pathway
F.M. Juliana, H. Nara, T. Onoda, M. Rahman, A. Araki, L. Jin, H. Fujii, N. Tanaka, T. Hoshino, Hironobu Asao;
Yamagata, Japan
277
P2.01.03 - Notch receptors and ligands expression in human T cell development
Luciana Bento-de-Souza, J. R. Victor, J.B. Oliveira Filho, A.C. Rangel-Santos, E. Pereira-Costa, L.C. Bento-de-Souza, M. Arrais-Santos,
E. Raniero-Fernandes, M.I. Seixas-Duarte, A.J. da Silva Duarte;
Sao Paulo, Brazil
278
P2.01.05 - Site-wide quantitative phosphoproteomics reveal non-redundant pathways regulated by IL-7 and IL-15 in
memory CD8+ T cells
Marlene J. Carrasco-Alfonso, S. Ficarro, Y. Zhang, W. Jiang, J. Marto, J. Luckey;
Boston, United States
279
P2.01.06 - Quantifying differential T cell responses using tuneable material surfaces
Susan N. Christo, B.R. Coad, G.T. Sarvestani, H.J. Griesser, K. Vasilev, R. Nordon, C.K. Fraser, M.P. Brown, K.R. Diener, J.D. Hayball;
Adelaide, Australia
280
P2.01.07 - Levodopa-induced neutropenia in Parkinson’s disease
Christian Cordano, B. Parodi, A. Uccelli, A. Schenone, L. Schembri, F. Marino, M. Cosentino;
Genova, Italy
281
P2.01.08 - Correlation between low tyrosine phosphatase activity of inhibitory SHP-1 and high proliferation in chronic
lymphocytic leukemia (CLL) B-cells
P. Delfani, Z. El-Schich, A. Rosén, Anette Gjörloff Wingren;
Malmö, Sweden
282
P2.01.09 - Functional regions in the Ankyrin Repeat Domain 54/ Liar protein which regulate nucleocytoplasmic shuttling
of Bruton’s Tyrosine Kinase (Btk) through a novel SH3-dependent interaction
Manuela O. Gustafsson, A. Hussain, D.K. Mohammad, A.J. Mohamed, C. Smith, B.F. Nore;
Huddinge, Sweden
97
Posters - August 23
283
P2.01.10 - Role of the long-chain fatty acids receptor GPR40 in bovine neutrophils activation
Maria A. Hidalgo, J. Mena, C. Manosalva, D. Carroza, R.A. Burgos;
Valdivia, Chile
284
P2.01.11 - Role of SLP-76, ADAP and Pyk2 on chemokine-stimulated T cell adhesion mediated by the integrin Alpha4-Beta1
Soledad Isern de Val, A. Dios-Esponera, J. Teixidó;
Madrid, Spain
285
P2.01.12 - Regulation of apoptosis by CD45 in T cells
Bruno Johnson, G. Dupéré-Minier, D. Bernier, J. Bernier;
Montreal, Canada
286
P2.01.13 - The SNARE protein VAMP7 controls T cell activation by regulating recruitment and phosphorylation of
Lat subsynaptic vesicles to the TCR activation sites
Paola Larghi, D.J. Williamson, J. Carpier, S. Dogniaux, K. Chemin, A. Bohineust, L. Danglot, K. Gaus, T. Galli, C. Hivroz;
Paris, France
287
P2.01.14 - Dual phosphorylation of Btk induced by Akt/PKB kinase regulating shuttling and attenuating signaling in B cells
Dara K. Mohammad, B.F. Nore, M.O. Gustafsson, A. Hussain, A.J. Mohamed, C. Smith;
Stockholm, Sweden
288
P2.01.15 - Role of SRC family kinases in the activation of ITK-SYK
Abdulrahman J. Mohammed Hamasy, A. Hussain, D.K. Mohammad, M.O. Gustafsson, B.F. Nore, A.J. Mohamed, C. Smith;
Stockholm, Sweden
289
P2.01.16 - CD137 Costimulation may compromise cytotoxic mediators of Natural Killer Cells
Shadi Navabi, A. Hosseini, M. Jaberipour, M. Doroudchi, M. Habibagahi;
Shiraz, Iran, Islamic Republic of
290
P2.01.17 - NFkB alternative pathway is activated in IgE class switching
Hitomi Sakamoto, K. Tanabe, S. Inui;
Kumamoto, Japan
291
P2.01.18 - Level of CD44 expression and its function distinguishes TH17 from TH1 cells
Julia Schumann, K. Stanko, C. Appelt, B. Sawitzki;
Berlin, Germany
292
P2.01.19 - CD28 and NKG2D-mediated costimulation regulates CD8+ T cell chemotaxis through different signaling pathways
Esther Serrano-Pertierra, E. Cernuda-Morollón, C. López-Larrea;
Oviedo, Spain
293
P2.01.20 - Inhibition of T cell receptor signaling by CD147
Verena Supper, H.B. Schiller, W. Paster, F. Forster, H. Stockinger;
Vienna, Austria
294
P2.01.21 - IL4-induced IgE class switching is regulated by NFkB alternative pathway
Kano Tanabe, H. Sakamoto, S. Inui;
Kumamoto, Japan
295
P2.01.22 - During human T cell activation ERK binds to a panel of promoters and regulates the transcription of target genes
Ubaid Ullah, N.C. Sahoo, P. Tripathi, R. Lahesmaa, K.V.S. Rao;
Turku, Finland
296
P2.01.23 - Paracrine ATP signalling between T lymphocytes
Chiuhui Mary M. Wang, F. Anselmi, J. Cibella, A. Viola;
Rozzano (MI), Italy
297
P2.01.25 - The Rho Family Guanine Nucleotide Exchange Factor, FARP1 negatively regulates T cell response
Yuji Yoshida, S. Kang, A. Kumanogoh;
Osaka, Japan
298
P2.01.26 - Interaction between Siglec-9 and prohibitins down-regulates T cell receptor signaling
Hajime Yurugi, H. Nakada;
Kyoto, Japan
299
P2.01.27 - PD-1 - PD-L1 interaction does not affect the ability of dendritic-like cells to activate human lymphocytes in vitro
Michał Zarzycki, K. Bocian, G. Korczak-Kowalska;
Warsaw, Poland
P2.10 AUTOPHAGY AND CELL DEATH IN THE IMMUNE SYSTEM
Session Time: Friday, August 23, 13:20 -15:00
300
P2.10.01 - Elucidating the role of UVRAG in T cell biology
Samia Afzal, H. Zhenyue, D. Brenner, T. Mak;
Toronto, Canada
301
P2.10.02 - Galectin-1 is a novel component of cytotoxic granules and contributes to in vivo CTL killing
Gustavo P. Amarante-Mendes, T.C. Machado, N.J. Vieira, M.J. Dominguez, T. Zorn, M. Dias-Baruffi, M.M. Rodrigues, S.J. Martin;
São Paulo, Brazil
302
P2.10.03 - Autocrine and paracrine interferon- directly enhances CD8 T cell motility and contact-dependent cytotoxicity
Purnima Bhat, G. Leggatt, N. Waterhouse, I. Frazer;
Buranda, Australia
98
Posters - August 23
303
P2.10.04 - SLAMF-1 is a signaling receptor modulating autophagy in a subset of chronic lymphocytic leukemia patients
with a good prognosis
Cinzia Bologna, R. Buonincontri, S. Serra, T. Vaisitti, V. Audrito, D. Brusa, S. Deaglio;
Turin, Italy
304
P2.10.05 - LPS induces intrinsic apoptosis of 6-sulfo LacNAc+ dendritic cells (slanDCs)
Deseada Camuesco, F. Calzetti, M. Cassatella;
Verona, Italy
305
P2.10.06 - Autophagy as a link between immunity and inflammation in idiopathic inflammatory myopathies
Cristina Cappelletti, G.N.A. Vattemi, P. Tonin, F. Salerno, L. Maggi, L. Morandi, M. Mora, G. Tomelleri, R. Mantegazza, P. Bernasconi;
Milan, Italy
306
P2.10.07 - O-linked N-acetylglucosaminyl transferase (Ogt) promotes the survival of mature B cells
Ming-Feng Chiang, C. Wu, K. Lin;
Taipei, Taiwan
307
P2.10.08 - Selective MHCII-mediated cell death as a potential mechanism for reversing inflammation in a
chemically-induced mouse model of colitis
Giuseppina F. Dusio, R.P. Tobin, L. Dao, S. Henderson, W. Cromer, H. Papacostantinou, M.K. Newell;
Temple, United States
308
P2.10.09 - Low-density lipoprotein receptor-related protein-1 (LRP-1) mediates autophagy and apoptosis caused by
Helicobacter pylori VacA
Toshiya Hirayama, K. Yahiro, M. Nakano, M. Noda, J. Moss;
Nagasaki, Japan
309
P2.10.10 - Suppression of Mcl-1 via RNA interference sensitizes human U937cells towards apoptosis induction
Mahdi Jafarlou, B. Baradaran, D. Shanehbandi, F. Othman;
Serdang, Malaysia
310
P2.10.11 - Bcl-2 antagonist as an immunomodulatory drug for transplantation
Andrew M. Lew, E.M. Carrington, I.B. Vikstrom, D.M. Tarlinton;
Parkville, Australia
311
P2.10.12 - CD95 (Fas) and CD178 (Fasl) induce apoptosis in CD4+ and CD8+ cells from peripheral blood and spleen in dogs
naturally infected by Leishmania spp
Valéria M. Lima, B.B. Oliveira, L.M. Melo, J. Perosso, K.L.O. Silva;
Araçatuba, Brazil
312
P2.10.14 - The effect of Z36 on Human T-cell Leukemia
Tsukasa Nakanishi, Y. Song, J. Tsukada, T. Kanazawa, Y. Yoshida;
Kitakyushu, Japan
313
P2.10.15 - An innovative method for assessing autophagy using the FlowSight imaging flow cytometer
Haley R. Pugsley, R. Kong, S.L. Friend, B.E. Hall, D.A. Basiji, P. Morrissey;
Seattle, United States
314
P2.10.16 - Accumulation of autophagic adaptor protein, p62/sequestosome 1, in the brains of Alzheimer’s disease
Kunikazu Tanji, T. Matsumiya, A. Maruyama, S. Odagiri, F. Mori, K. Itoh, A. Kakita, H. Takahashi, K. Wakabayashi;
Hirosaki, Japan
315
P2.10.17 - Interference of modified vaccinia virus Ankara with autophagy: implications for innate and adaptive immunity
Kim A. Tappe, M.V. Stankov, T. Frenz, U. Kalinke, G.M.N. Behrens;
Hannover, Germany
316
P2.10.18 - Mechanisms of cytotoxic effects of different monoclonal antibody to tumor-associated ganglioside GD2
Polina Vishnyakova, I. Kholodenko, I. Molotkovskaya, R. Kholodenko;
Moscow, Russian Federation
317
P2.10.19 - Transcriptional control of FAS-ligand regulates the differential activation induced cell death of human Thelper
cells
Elisabetta Volpe, G. Ruocco, S. Santini, M. Cencioni, G. Borsellino, M. De Bardi, D. Barilà, L. Battistini;
Rome, Italy
318
P2.10.20 - BCL3, induced by Tax and HTLV-1, inhibits NF-κB activation and promotes autophagy
Hui Wang, J. Wang, Z. Niu, C. Gao, J. Han, X. Zhu, X. Song;
Xinxiang, China
319
P2.10.21 - A protective role of autophagy as an anti-oxidant system in human primary T cells: a potential therapeutic
strategy for autoimmune diseases
Ryu Watanabe, H. Fujii, T. Shirai, S. Saito, T. Ishii, H. Harigae;
Sendai, Miyagi, Japan
320
P2.10.22 - Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent
cell death
S. Hong, I. Hwang, S. Park, Je-Wook Yu;
Seoul, Korea, Republic of
321
P2.10.24 - Rapid Dynamic Exchange of LC3 in Intracellular Protein Aggregates but not in Autophagosomes
L. Wang, Zhihong Zhang;
Wuhan, China
99
Posters - August 23
P3.01 LYMPHOID ORGANOGENESIS AND LINEAGE COMMITMENT
Session Time: Friday, August 23, 13:20 -15:00
322
P3.01.01 - The role of ADAM10 in B cell biology
Natalia Chaimowitz, R. Martin, L. Dean, D. Conrad;
Richmond, United States
323
P3.01.02 - Roles of Polycomb group proteins in the maintenance of T cell fate
Tomokatsu Ikawa, H. Koseki, H. Kawamoto;
Yokohama, Japan
324
P3.01.03 - The repression of myeloid genes by Bach family restricts common lymphoid progenitors fate to B cell lineage
Ari Itoh-Nakadai, R. Hikota, M. Matsui-Watanabe, M. Kobayashi, A. Muto, K. Igarashi;
Miyagi, Japan
325
P3.01.04 - FoxN1 is a Direct Transcriptional Regulator of Delta-like 4 in Thymic Stromal Cells
Korosh Kianizad, H. Naik, D.K. Shah, M. Mohtashami, J.C. Zuniga-Pflucker;
Toronto, Canada
326
P3.01.05 - Features of colony-forming cells-fibroblast precursors circulating in biological fluids
Olga V. Lebedinskaya;
Perm, Russian Federation
327
P3.01.06 - Protein kinase CK2beta is an essential regulator of peripheral B cell development
Fortunato Zaffino, S. Manni, E. Mandato, L. Quotti Tubi, A. Brancalion, N. Compagno, B. Boldyreff, O. Filhol-Cochet, G. Semenzato,
F. Piazza;
Padova, Italy
328
P3.01.07 - Poly(ADP-ribose)polymerase-1 (PARP-1) negatively controls regulatory T cell differentiation
F. Novelli, E. Bennici, F. Laudisi, M. Sambucci, Claudio Pioli;
Rome, Italy
329
P3.01.08 - The critical role of NADPH oxidase on inducible bronchus-associated lymphoid tissue formation in newborn mice
Ting-Jing Shen, Y. Lin, C. Shieh;
Tainan, Taiwan
330
P3.01.09 - Plasticity of antigen-specific Th17 and Regulatory T Cells in response to environmental cues
Gabriela P. Tejón, V. Manríquez, J.R. Mora, M.R. Bono, M. Rosemblatt;
Santiago, Chile
P3.03 THYMIC SELECTION AND T CELL DEVELOPMENT
Session Time: Friday, August 23, 13:20 -15:00
331
P3.03.01 - Role of sonic hedgehog in T cell development
Amal Al-Shammary;
London, United Kingdom
332
P3.03.02 - Analysing the role of E2F7 and E2F8 in peripheral T cells and during T cell development
Jane Beil, R. Sapkota, A. Sledzinska, A. de Bruin, T. Buch;
Munich, Germany
333
P3.03.03 - CCL2 chemokine in central tolerance
Oriane Cédile, M. Løbner, H. Toft-Hansen, I. Frank, M. Irla, T. Owens;
Odense, Denmark
334
P3.03.04 - Does citrullination occur in medullary thymic epithelial cells?
Robby Engelmann, A. Biemelt, A. Johl, B. Müller-Hilke;
Rostock, Germany
335
P3.03.05 - Significant involvement of NF-κB-inducing Kinase in shaping mature T cell repertoire
Koji Eshima, N. Shinohara, K. Iwabuchi;
Sagamihara, Kanagawa, Japan
336
P3.03.06 - Homeostatic properties and phenotypic maturation of murine CD4+ pre-thymic emigrants in the thymus
Qing Ge, X. Xu, J. Dong;
Beijing, China
337
P3.03.07 - Transcriptional modification induced in a human epithelial cell line by transfected AIRE
Carolina Guitart, F. Reyes, I. Alvarez, S. Boltaña, D. Jaraquemada;
Bellaterra, Barcelona, Spain
338
P3.03.08 - SOCS1 deficiency results in fatal inflammatory disease in the absence of thymic T cells
Hiromi Honda, T. Ohkawara, M. Fujimoto, S. Lee, T. Kishimoto, T. Naka;
Ibaraki, Osaka, Japan
339
P3.03.09 - Regulation of CD8 T cell function by the small GTPase Arl4d
Julita Kaczmarek, L. Diehl;
Bonn, Germany
340
P3.03.10 - Signal integration in thymocytes is crucial for thymic selection
Sahamoddin Khailaie, A. Toker, J. Hühn, M. Meyer-Hermann;
Braunschweig, Germany
100
Posters - August 23
341
P3.03.11 - Vascular Endothelial Growth Factor and Semaphorin 3A influence murine thymocyte migration in vitro
Ekaterina P. Kisseleva, I.V. Lyamina;
St.Petersburg, Russian Federation
342
P3.03.12 - Shaping of epitope-specific CTL precursor populations by thymic selection
J. Guan, W. Kan, S.J. Turner, Nicole L. La Gruta;
Parkville, Australia
343
P3.03.13 - CD8aa TCRab intraepithelial lymphocytes MHC restriction
S. Mayans, D. Stepniak, S. Palida, A. Larange, H. Cheroutre, Florence Lambolez;
La Jolla, United States
344
P3.03.14 - The role of WW domain-containing oxidoreductase in lymphocyte development
Jui-Yen Lo, L. Hsu;
Tainan, Taiwan
345
P3.03.15 - The investigation of the expression of P2Y1 and P2Y2 nucleotide receptors on thymocytes using monoclonal
antibodies
Milda Naciute, R. Kvietkauskaite, N. Gerasimcik, J. Jursenaite, M. Mauricas, I. Girkontaite;
Vilnius, Lithuania
346
P3.03.16 - Role of Miz-1 (Myc-Interacting Zinc-finger protein-1) as a regulator of p53 dependent pathways during pre TCR
selection
Marissa Rashkovan, C. Kosan, T. Möröy;
Montreal, Canada
347
P3.03.17 - Thymic nurse cells play an important role in MHC restriction and express progenitor markers associated with
epithelial maintenance
Michael D. Samms;
New York, United States
348
P3.03.18 - TCRβ but not the TCRδ enhancer exerts transcriptional control on the TCR locus during development
Ravindra M. Sapkota, A. Sledzinska, C. Uthoff-Hachenberg, B. Becher, T. Buch;
Zurich, Switzerland
349
P3.03.19 - Pharmacological inhibition of glycogen synthase kinase 3 regulates T cell development in vitro
Jan-Hendrik Schroeder, L. Bell, M. Janas, M. Turner;
London, United Kingdom
350
P3.03.20 - Role of conserved MHC residues for interaction with T cell antigen receptors
Daniel Silberman, P. Marrack, J.W. Kappler;
Denver, United States
351
P3.03.21 - Generation of a conditional knock-out mouse for SATB1 to study its importance for CD4+ T cells
Daniel Sommer, A. Peters, T. Wirtz, M. Mai, Y. Thabet, J. Degen, J.L. Schultze, M. Beyer;
Bonn, Germany
352
P3.03.22 - Themis CABIT domains exert distinct functions in thymocyte positive selection
Harumi Suzuki, T. Okada, T. Nitta, K. Kaji, H. Oda, M.S. Ppatrick;
Ichikawa-shi, Chiba, Japan
353
P3.03.23 - Background of Primary Immunodeficiencies in Patients with Severe Atopic Dermatitis
Babak Torabi Sagvand, A. Aghamohammadi, Z. Gholizadeh Moghaddam, B. Mirminachi, H. Abolhassani, Z. Hallaji, H. Mortazavi,
H. Mortazavi, P. Mohammadinejad;
Tehran, Iran, Islamic Republic of
354
P3.03.24 - A single cell approach to investigating the role of asymmetric cell division in fate determination of CD8+ T cells
Mohammed Yassin, R. Shimoni, K. Pham, J. Oliaro, M. Ludford-Menting, S. Russell;
Melbourne, Australia
355
P3.03.25 - Thymectomy in early childhood: decrease of naive CD4+ T cells and diminished immune response after vaccination
Manuela Zlamy, C. Gögele, R. Würzner, R. Geiger, L.B. Zimmerhackl, M. Prelog;
Innsbruck, Austria
P4.13 IMMUNE REGULATION AT BARRIER SITES
Session Time: Friday, August 23, 2013 1:20:00 PM - 3:00:00 PM
356
P4.13.01 - Host defense peptide CRAMP acts as a potent mast cell chemoattractant and mediator release stimulus
Edyta Bolewska, P. Witczak, A. Słodka, A. Pietrzak, E. Brzezi ska-Błaszczyk;
Łód , Poland
357
P4.13.02 - Chemerin is an antimicrobial agent in human epithelium
Magdalena Banas, K. Zabieglo, M. Kapinska-Mrowiecka, J. Drukala, K. Murzyn, B.A. Zabel, E.C. Butcher, J.M. Schroeder, A. Schmidtchen,
J. Cichy;
Cracow, Poland
358
P4.13.03 - Bcl3 expression is increased in Irritable Bowel Syndrome (IBS) patients independently of IL-10
Caroll J. Beltrán, A.M. Madrid, C. Defilippi, K. Nally, S. Melgar, J.F. Cryan, T.G. Dinan, E.M. Quigley;
Santiago, Chile
359
P4.13.04 - Soluble factor produced by Staphylococcus aureus modulates the cell cycle of eukaryotic cells
Nadia Nadejda Berkova, E. Ladier, L. Alexseeva, M. Deplanche, S. Almeida, V. Azevedo, S. Even, F. Taieb, Y. Arlot-Bonnemains,
Y. Le Loir;
Rennes, France
101
Posters - August 23
360
P4.13.05 - Characterization of a lymphocyte inhibitor from Aedes aegypti saliva
Bruna Bizzarro, M.S. Barros, A.D. Ramos, J. Campopiano, D.I. Gueroni, G.P. Amarante-Mendes, E. Calvo, J.M. Ribeiro, M.L. Capurro,
A. Sá-Nunes;
São Paulo, Brazil
361
P4.13.06 - Expression and regulation of TSLP in human oral mucosa and cultured oral keratinocytes
Louise Bjerkan, O. Schreurs, L. Farkas, F. Jahnsen, E. Baekkevold, I. Blix, K. Schenck;
Oslo, Norway
362
P4.13.07 - Induction of Interleukin-10 expression by the commensal microbiota in intestinal regulatory T-cells
Julia Bollrath, M. Barnes, A. Johnson, M. Asquith, H. Waldmann, R. Flavell, S. Hori, K. Maloy, F. Powrie;
Oxford, United Kingdom
363
P4.13.08 - Helicobacter pylori HP0175 promotes the production of IL-23, IL-6, IL-1β and TGF-β
Chiara Della Bella, A. Amedei, F. Munari, E. Niccolai, M. Benagiano, G. Zanotti, M. de Bernard, M. Kundu, M.M. D’Elios;
Florence, Italy
364
P4.13.09 - Mechanistic insights into Helicobacter pylori pathogenesis and host response
Bow Ho;
National University of Singapore, Singapore
365
P4.13.10 - Intestinal mucosal barrier in experimentally induced septic shock and gut inflammation
Michaela Hornova, Z. Zakostelska, K. Klimesova, J. Hrdy, H. Tlaskalova - Hogenova, M. Kverka;
Prague, Czech Republic
366
P4.13.11 - Homeostatic proliferation of naïve CD4+ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells
Takeshi Kawabe, S. Sun, A. Asao, T. Takahashi, T. So, N. Ishii;
Sendai, Japan
367
P4.13.13 - The flagellin sensor NLRC4 mediates protection against a mucosal pathogen
Sofia Nordlander, K.J. Maloy;
Oxford, United Kingdom
368
P4.13.14 - Brucella abortus 2308 induce downregulation of the activation markers in murine B cells
Maricela Ramírez-Saldaña, V. Paredes- Cervantes, M. Aguilar-Santelises, J.M. Hernández- Dominguez, M.C. Moreno-Lafont, R. LópezSantiago;
México D.F., Mexico
369
P4.13.15 - Transcription factor Spi-B-dependent and -independent pathways for the development of Peyer’s patch M cells
Shintaro Sato, S. Kaneto, H. Kiyono;
Tokyo, Japan
370
P4.13.16 - Influenza virus infection induces long-term and compartmentalised derangement of airway and lung dendritic
cell subsets
Philip A. Stumbles, C. von Garnier, M. Smith, V. Fear, E. Bozanich, C. Berry, D. Strickland, P. Holt;
Perth, Australia
371
P4.13.17 - Translation of Tollip is inhibited in the small but not large intestinal epithelial cells
Yutaka Sugi, K. Takahashi, T. Kobayakawa, A. Hosono, S. Kaminogawa;
Fujisawa-shi Kanagawa, Japan
372
P4.13.18 - Monoclonal intestinal IgAs are poly-reactive against commensal bacteria but recognize a single protein
expressed by multiple bacteria
Fumihito Usui, S. Okai, M. Hasegawa, R. Shinkura;
Nagahama, Japan
373
P4.13.19 - Density of FOXP3+ T cells and CD11c+ dendritic cells in small bowel mucosa in children with atopic dermatitis,
celiac disease and functional gastrointestinal disorders
Tamara Vorobjova, K. Ress, K. Lepik, K. Luts, O. Uibo, R. Uibo;
Tartu, Estonia
374
P4.13.20 - Foxp3+ regulatory T cells promote a protective Th17 cell response against intestinal infection with Citrobacter
rodentium
Zuobai Wang, S. Cording, S.C. Pohl, C. Friedrich, G. Eberl, T. Sparwasser, M. Lochner;
Hannover, Germany
375
P4.13.21 - Toward prediction of immune signatures of health
Nicholas P. West, P.L. Horn, D.B. Pyne, L. Lee, S. Asad, S.J. Lahtinen, M. Lehtinen, P.A. Fricker, B. Fazekas de St Groth, A.W. Cripps;
Gold Coast, Australia
P5.01 CYTOKINE REGULATION IN DISEASE
Session Time: Friday, August 23, 13:20 -15:00
376
P5.01.01 - Study of IL-23 expression level in liver transplanted patients
Afsoon Afshari, R. Yaghoobi, M. Karimi, M. Darbouy;
Shiraz, Iran, Islamic Republic of
377
P5.01.02 - Effects of dexamethasone on IL-6 and IL-8 expression induced by TGF-β1 in colon cancer cells
Omair Al Shahrani, M. Alanazi, A. Semlali;
Riyadh, Saudi Arabia
378
P5.01.03 - Antitumor effect of a hydroalcoholic extract of Uncaria tomentosa in a murine C57BL/6- B16 melanoma model
Yubell P. Alvarez Valdivia, I. Lozada-Requena, C. Núñez, S. Dávila, T. Ysmodes, A. Vaisberg, C. Acuña, J.L. Aguilar;
Lima, Peru
102
Posters - August 23
379
P5.01.04 - Modulation of Oxido-Nitrosative Stress Induced Neuro-Inflammatory Cascade & Monoaminergic Pathway By
Resveratrol In Reserpine Induced Pain Depression Dyad In Rats
Vipin Arora, K. Chopra;
Chandigarh, India
380
P5.01.05 - Maternal cytokine production patterns in women with pre-eclampsia
Fawaz Azizieh, R. Raghupathy, M. Makhseed;
Kuwait, Kuwait
381
P5.01.06 - Suppressive Role of IL-27 against Pro-inflammatory Role of IL-17A in Patients with Multiple Sclerosis
Zohreh Babaloo, R. Kh. Yeganeh, M. farhoodi, B. Baradaran, M. Boniadi;
Tabriz, Iran, Islamic Republic of
382
P5.01.07 - Immune mechanisms in periodontitis - effect of IL-4 gene polymorphisms on cytokine production
Jirina Bartova, P. Borilova Linhartova, S. Podzimek, K. Svobodova, T. Janatova, A. Fassmann, J. Duskova, L. Izakovicova-Holla;
Prague, Czech Republic
383
P5.01.08 - Concentration Levels of IL -10 and TNF-α Cytokines in Patients with HPV DNA Positive and Negative Cervical Lesions
Husham Y.M. Bayazed;
Zakho, Iraq
384
P5.01.09 - The inflammatory cytokine TNFalpha cooperates with hyper-activated Ras in promoting metastasis and turns
WT-Ras into an oncogenic entity
T. Leibovich-Rivkin, Y. Liubomirski, T. Meshel, A. Abahidze, A. Abahidze, D. Brisker, H. Solomon, V. Rotter, M. Weil, Adit Ben-Baruch;
Tel Aviv, Israel
385
P5.01.10 - Cytokines, depression, and anxiety in patients with colorectal cancer
D.O. Miranda, L.R. Azevedo, T.A.S. Lima, O. Feres, J.J.R. Rocha, Gabriela S. Bisson;
Ribeirão Preto, Brazil
386
P5.01.11 - IL-17 protects T cells from apoptosis and contributes to development of ALPS-like pictures
Elena Boggio, N. Clemente, U. Ramenghi, U. Dianzani, A. Chiocchetti;
novara, Italy
387
P5.01.12 - Haplotype analysis of interleukin-8 gene polymorphisms in chronic and aggressive periodontitis
Petra Borilova Linhartova, J. Vokurka, H. Poskerova, A. Fassmann, L. Izakovicova Holla;
Brno, Czech Republic
388
P5.01.13 - Analysis of Th17 cells and IL-17, IL-23 cytokines in peripheral blood from children with autoimmune thyroid
disease
Artur A. Bossowski, M. Moniuszko, M. Dabrowska, M. Jeznach, A. Bossowska, M. Rusak, A. Bo ena-Lukaszyk;
Bialystok, Poland
389
P5.01.14 - Cryoglobulins are involved in pathomechanisms of altered immune response associated with schizophrenia and
ischemic stroke
Anna Boyajyan, A. Chavushyan, M. Hovsepyan, M. Hovhannisyan;
Yerevan, Armenia
390
P5.01.15 - IL-17 plays a critical pathogenic role in lung cancer
Seon Hee Chang, S. Mirabolfathinejad, A. Cumpian, C. Ochoa, L. Gong, S. Moghaddam, C. Dong;
Houston, United States
391
P5.01.16 - Effects of imiquimod treatment on TNF expression in two-step skin carcinogenesis model in mice
Anna A. Chashchina, S.V. Bozrova, R.V. Zvartsev, T. Kammertoens, V.A. Levitsky, S.A. Nedospasov, M.S. Drutskaya;
Moscow, Russian Federation
392
P5.01.17 - Interferon gamma supresses collagen-induced arthritis through regulation of IL-17 : possible role of
indoleamine 2,3 deoxygenase
Mi-La Cho, J. Jhun, M. Lim, J. Lee, J. Lee, S. Park;
Seoul, Korea, Republic of
393
P5.01.18 - GLK controls Th17-mediated autoimmunity and NF-κΒ signaling by activating PKC-θ in T cells
Huai-Chia Chuang, J. Lan, D. Chen, T. Tan;
Zhunan Miaoli County, Taiwan
394
P5.01.19 - Immune response to a mixture of bacterial lysates in a rat model
Dagoberto Cid Guerrero, J. Martinez Castillo, I. Vargas Rodriguez, S. Sanchez Rodriguez, R. Ramirez Santoyo, E. Lopez Robles;
Zacatecas, Mexico
395
P5.01.20 - Regulation of lymphoma B cell proliferation by IL-31 and its receptor
E. Ferretti, G. Pagnan, C. Guarnotta, G. Fraternali-Orcioni, S. Zupo, C. Tripodo, V. Pistoia, Anna Corcione;
Genova, Italy
396
P5.01.21 - Evaluation of potential serum biomarkers for periodontal disease in type 1 diabetes mellitus children
Cristiane Duque, M.F. Dib, F.S. Mariano, G.A.C.G. Camargo, N.H. Colombo, R.O. Mattos-Graner;
Araçatuba, Brazil
397
P5.01.22 - Influence of TLR2 in the cytokine profile after S. schenckii infection
Cristiane Duque, T.d. Negrini, L.S. Ferreira, P. Alegranci, M.C.P. Placeres, R.A. Arthur, L.C. Spolidorio, I.Z. Carlos;
Araçatuba, Brazil
398
P5.01.23 - Lack of correlation between IL-21 and type I IFN signature suggests different roads to pathogenesis in
Rheumatoid Arthritis
Rachel Ettinger, J.L. Karnell, C.A. Morehouse, E. Grant, D. Taylor, M. Wilson, R. Goldbach-Mansky, Y. Yao, R. Herbst, L. Carter;
Gaithersburg, United States
103
Posters - August 23
399
P5.01.25 - Expression of cytokine and Chemokine receptors on benign and malignant ovarian tissues
Abbas Ghaderi, S. Rezaeifard, M. Razmkhah, M. Robati, M. Momtahan;
Shiraz, Iran, Islamic Republic of
400
P5.01.26 - Role of transcription factor and chromatin remodeler interplay in the regulation of TNFα induced MHC-I gene expression
Sadashib Ghosh, E. Sen;
Gurgaon, India
401
P5.01.27 - BET bromodomain inhibition by JQ1 suppresses interleukin-6 secretion in myeloma cells
Rohit R. Ghurye, H.J.S. Stewart, T.J. Chevassut;
Brighton, United Kingdom
402
P5.01.28 - Dynamics of IL-1ά, IL-4 and IFN-γ in children with atopic asthma in therapy Leukinferon
Naila M. Gulieva;
Baku, Azerbaijan
403
P5.01.29 - Cellular responses to Staphylococcus aureus alpha-toxin in chronic rhinosinnusitis with nasal polyps
Takenori Haruna, M. Okano, S. Kariya, T. Koyama, K. Nishizaki;
Okayama, Japan
404
P5.01.30 - Imbalance of homeostatic cytokines in APECED
Nelli Heikkilä, S.M. Laakso, H. Jarva, T.P. Arstila;
Helsinki, Finland
405
P5.01.31 - Substantially elevated plasma IL-1β levels and hyporeactivity to IL-1β in APECED
Iivo Hetemäki, V. Veckman, H. Jarva, S. Matikainen, T.P. Arstila;
Helsinki, Finland
406
P5.01.32 - Effects of Siegesbeckia orientalis ethanol extract on systemic and local inflammatory reactions
Yong-Han Hong, J. Houng;
Kaohsiung, Taiwan
407
P5.01.33 - Metformin modulates inflammatory response through AMPK-NF-κB signaling and restores atherogenic effects
Bobae Hyun, S. Shin, A. Lee, S. Lee, Y. Song, K. Cho, K. Kim;
Seoul, Korea, Republic of
408
P5.01.34 - Immunomodulatory effects of N-(2-hydroxy phenyl) acetamide on pro-inflammatory cytokines and ROS in
adjuvant-induced arthritic rats
Huma Jawed, S. Jamall, S.U. Simjee;
Karachi, Pakistan
409
P5.01.35 - Redox balance of mouse medullary CD4 single positive thymocytes
Rong Jin;
Beijing, China
410
P5.01.36 - Low level of TNF-alpa in cystic fluid is accompanied with low number of macrophages in cystic wall of
odontogenic tumor
Vladimir Jurisic, T. Terzic, M. Jurisic;
Kragujevac, Serbia
411
P5.01.37 - Effect of immunoglobulin E on plasmacytoid dendritic cells in systemic lupus erythematosus pathogenesis
through interferon-alpha downregulation
Liliane Khoryati, I. Douchet, C. Contin-Bordes, P. Blanco, C. Richez;
Bordeaux, France
412
P5.01.38 - Correlation of some Inflammation related cytokines and biochemical markers amongst individuals with high,
medium and normal serum FBS levels
Afra Khosravi, F. Nasiri, K. Sayemiri;
Ilam, Iran, Islamic Republic of
413
P5.01.39 - Critical roles of oncostatin M receptor signaling on the polarization of macrophage phenotypes, adipose tissue
inflammation, and the development of insulin resistance
Tadasuke Komori, M. Tanaka, E. Senba, A. Miyajima, Y. Morikawa;
Wakayama, Japan
414
P5.01.40 - Serum soluble IFNAR2 levels in autoimmune diseases suggest that chronic IFN signaling leads to elevated levels of
sIFNAR2
T. Fatakdawala, M. Skawinski, T. Stauffer, J. Ferriera, Thomas B. Lavoie;
Piscataway, United States
415
P5.01.41 - IL-4: a key cytokine in acutely rejected neo-antigen specific skin grafts
Victoria M. Leb-Reichl, S. Kitzmueller, D. Peckl-Schmid, M. Ettinger, H. Hintner, J.W. Bauer;
Salzburg, Austria
416
P5.01.42 - Aryl hydrocarbon receptor negatively regulates type I interferon production in murine lupus
Soyoung Lee, R. Barry, I. Chinen, D. Millrine, T. Kishimoto;
Osaka, Japan
417
P5.01.43 - Proinflammatory cytokines in patients with chronic traumatic encephalopathy
Yevgeniya Lekomtseva, G. Gubina-Vakulik;
Kharkiv, Ukraine
418
P5.01.44 - Effect of lithium carbonate treatment in mRNA levels of pro- and anti-inflammatory cytokines and expression
of Wnt/beta-catenin pathway genes in PBMC of bipolar patients
Maria C.A. Luque, T.M. Ali, C. Moreira, B. Lafer, J. Kalil, E. Cunha-Neto;
São Paulo, Brazil
104
Posters - August 23
419
P5.01.48 - Anti-inflammatory effects of high-dose IgG on TNF-α-, but not IL-1β-activated human coronary artery
endothelial cells
Akio Matsuda, H. Morita, H. Unno, K. Motomura, H. Saito, K. Matsumoto, J. Abe;
Tokyo, Japan
420
P5.01.49 - Association of modulatory cytokine gene polymorphisms in resistance and susceptibility to polyparasitism
infection in Zimbabwe
Takafira Mduluza, N. Midzi, P. Chitongo, E. Gori, T. Ruwona, G. Mlambo, S.L. Mutambu, N. Kumar;
Harare, Zimbabwe
421
P5.01.50 - Interleukin-17A involvement in host defense against Echinococcus granulosus infection
Dalila Mezioug, C. Touil-Boukoffa;
El-Alia, Algeria
422
P5.01.51 - Interleukin-17A involvement in host defense against Echinococcus granulosus infection
Dalila Mezioug, C. Touil-Boukoffa;
Algiers, Algeria
423
P5.01.52 - EBI3 functions as an intracellular molecule to regulate the development of colitis in naive CD4+CD25- T cells
Izuru Mizoguchi, K. Mitobe, R. Tsunoda, K. Higuchi, J. Mizuguchi, T. Yoshimoto;
Tokyo, Japan
424
P5.01.53 - Prostaglandin D2 represents contradicting roles in dermatitis
H. Sarashina, Y. Tsubosaka, K. Aritake, T. Nakagawa, M. Hori, H. Ozaki, Y. Urade, Takahisa Murata;
Tokyo, Japan
425
P5.01.54 - ST2/IL-33 signaling worsens immune-mediated hepatitis from drug haptens
S. Goodman, J. Cho, L. Kim, M. Haham, Dolores Njoku;
Baltimore, United States
426
P5.01.55 - Lack of TNF-Rp55 delays thrombus resolution in a stasis-induced DVT model through reduced MMPs and uPA
expression
Mizuho Nosaka, Y. Ishida, A. Kimura, Y. Kuninaka, N. Mukaida, T. Kondo;
Wakayama, Japan
427
P5.01.56 - Impaired production of IL-10 in response to Staphylococcus aureus alpha-toxin is closely associated with
pathophysiology and postoperative outcome in chronic rhinosinusitis with nasal polyps
Mitsuhiro Okano;
Okayama, Japan
428
P5.01.57 - IL6 trans-signaling promotes functional recovery of hypofunctional phagocytes through STAT3 activation during
peritonitis
Tsuyoshi Onogawa, T. Saito-Taki, H. Yamamoto, T. Wada;
Hachioji, Tokyo, Japan
429
P5.01.58 - Cytokines as molecular biomarkers for cancer cachexia
Claudia Penafuerte, J. Sirois, M.L. Tremblay, B. Gagnon;
Montreal, Canada
430
P5.01.59 - Cytokine profile changes following exposure to Hemiscorpius lepturus scorpion venom under experimental conditions
Mohammad Hassan Pipelzadeh, A. Khodadadi, Y. Heike, M. Assarehzadegan, M. Assarehzadegan, B. Vazirianzadeh;
Ahvaz, Iran, Islamic Republic of
431
P5.01.60 - The knock-out of TWEAK receptor/Fn14 ameliorates lupus nephritis in MRL/lpr mice
Y. Xia, L. Herlitz, L. Burkly, R. Pawar, S. Gindea, P. Wu, J. Michaelson, Chaim Putterman;
Bronx, United States
432
P5.01.61 - Inhibiting TWEAK (TNF-like weak inducer of apoptosis) signaling ameliorates neuropsychiatric disease in MRL/lpr mice
Chaim Putterman;
Bronx, United States
433
P5.01.63 - Serum level of immunoglobulins in patients with respiratory allergic diseases
Badrossadat Rahnama, B. Hazhirkarzar, H. Ghaffari, M. Zamanlu;
tabriz, Iran, Islamic Republic of
434
P5.01.64 - The electromagnetic fields affect T-helper balance in rats
Badrossadat Rahnama, M. Zamanlu, B. Hajir Karzar, M. Bonyadi, A. Khaki;
Tabriz, Iran, Islamic Republic of
435
P5.01.65 - TWEAK Affects Keratinocyte G2/M Growth Arrest and Induces Apoptosis through the Translocation of the AIF
Protein to the nucleus
Sanaa Sabour Alaoui;
El Jadida, Morocco
436
P5.01.66 - PI3K/PTEN axis in APCs is regulating Th17-dependent autoimmune pathology
Emine Sahin, V. Saferding, J. Brunner, J. Kral, N. Neuwinger, I. Kollmann, K. Thell, S. Blüml, G. Schabbauer;
Vienna, Austria
437
P5.01.67 - Cytokine patterns during high-risk human papillomavirus and HIV co-infection in cervical cancer patients and
controls in Kwazulu-Natal (South Africa)
Devamani Sebastian, A.G. Assounga;
Durban, South Africa
438
P5.01.68 - Mechanisms of immunosuppression and interleukin 2 in complex treatment of severe acute pancreatitis
Mariya Shavarova, S. Chooklin;
Lviv, Ukraine
105
Posters - August 23
439
P5.01.69 - Tuberculosis infection diagnosis by Quantiferon TB Gold In-Tube Test assessment in Namibian patients
Jacob A. Sheehama, J.J. Nelongo, E.E. Nepolo, S.N. Iipinge;
Windhoek, Namibia
440
P5.01.70 - Antiplatelets drugs reduces the immunoinflammatory response in a rat model of periodontal disease
Luís Carlos Spolidorio, J. Steffens, M. Nicolas Muscará, C. Rossa Jr, D. Graves, L. Santana Coimbra;
Araraquara, Brazil
441
P5.01.71 - Vitamin D and Interferon-beta act synergistically at physiological levels to modulate cytokine expression in
vitro in peripheral blood mononuclear cells
Niall J. Stewart, S. Simpson Jr., B. Taylor;
Hobart, Australia
442
P5.01.72 - Carbon monoxide (CO) as a novel approach for treatment of islet-directed autoimmunity
Stanislava Stosic-Grujicic, I. Nikolic, M. Vujicic, T. Saksida, F. Nicoletti, I. Stojanovic;
Belgrade, Serbia
443
P5.01.73 - IL-2 induces robust inflammatory responses in the lung that synergize with influenza virus to exacerbate
immunopathology
Tara M. Strutt, K.K. McKinstry, S.L. Swain;
Worcester, United States
444
P5.01.74 - Lnk/Sh2b3, an intracellular adaptor associated with celiac disease and autoimmune diabetes, regulates
accumulation of inflammatory T cells and prevents intestinal villous atrophy
T. Mori, H. Katayama, Y. Iwasaki, Y. Seki, M. Iseki, M. Ikutani, N. Yoshida, K. Takatsu, Satoshi Takaki;
Ichikawa, Chiba, Japan
445
P5.01.76 - Role of TNF-α, their receptors and gene‘s polymorphism in patients with coronary atherosclerosis
Ekaterina Turmova, A. Silaev, E. Shkorik, E. Markelova, R. Cromovoy;
Vladivostol, Russian Federation
446
P5.01.78 - Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell
responsiveness and dendritic cell activity
Yufeng Yin, Y. Li, L. Zhao, S. Qian, L. Tong, D. Ba, W. He, X. Cao, X. Zhang, P. Lipsky;
Beijing, China
447
P5.01.79 - BAFF induces IL-6 production in human monocytes through signaling pathways that involve NF-kB and PI3 kinase
Keiko Yoshimoto, M. Tanaka, M. Kojima, H. Ogata, K. Suzuki, H. Kameda, T. Abe, T. Takeuchi;
Tokyo, Japan
448
P5.01.80 - Increased levels of IL-6, TNF-a, MIF, IL-8, and MCP-1 in schizophrenia
Roksana Zakharyan, S. Atshemyan, A. Boyajyan;
Yerevan, Armenia
449
P5.01.81 - Assay of IL-22/IL-25 in serum, whole blood and peripheral blood mononuclear cells cultures of patients with
severe asthma
Alireza Zamani, E. Nadi, M. Arjipour, S. Sharifi;
Hamadan, Iran, Islamic Republic of
450
P5.01.82 - Status of cytokine line and morphological changes in endocrine glands of rats with tentative thyrotoxicosis
Victoria Zdor (Lazanovich), E. Markelova, Y. Tikhonov;
Vladivostok, Russian Federation
451
P5.01.83 - Lithium treatment reduced microglia activation and inflammation after irradiation to the immature brain
Changlian Zhu, K. Zhou, C. Xie, K. Blomgren;
Göteborg, Sweden
P5.02 CHRONIC INFLAMMATION AND FIBROSIS
Session Time: Friday, August 23, 13:20 -15:00
452
P5.02.01 - IL-17 and IFNγ decrease in the gut of rats with experimental fibrosis. “Possible association with bacterial translocation”
Miriam R. Bueno Topete, E. Sánchez, S. Zepeda Morales, E. Rodríguez, S. del Toro Arreola, L. García Benavides, M. Fafutis Morris,
A. Domínguez, F. Muñoz Valle;
Guadalajara, Mexico
453
P5.02.02 - Experimenrtal cholestasis is associated with increased IL-17 and IFN-γ expression
S.M. Zepeda Morales, S. del Toro Arreola, M. Fafutis Morris, E. Bastidas Ramírez, V. Delgado Rizo, Miriam R. Bueno Topete;
Guadalajara, Mexico
454
P5.02.03 - ITF2357 inhibits corneal fibrosis and inflammation via JAK/STAT3 signaling pathway
Shyam S. Chaurasia, A. Tan, R. Lim, Y. Liu, J.S. Mehta;
Singapore, Singapore
455
P5.02.04 - Osteopenia and inflammation in postmenopausal women
L. Ginaldi, Fedra Ciccarelli, M. De Martinis;
L’Aquila, Italy
456
P5.02.05 - Type 2 Innate Lymphoid Cells (ILC2) are present in mouse models of lung and skin fibrosis and their numbers
correlate with disease severity
Preeta Dasgupta, T. Burwell, R. Johnson, J. Bakken, R. Herbst, J. Connor, R. Lemaire;
Gaithersburg, United States
457
P5.02.06 - Prevalence of skin sensitivity to aeroallergens in Iranian patients with nasal polyposis
Mohammad Fereidouni, M. Bakhsahee, S. Nourani hasan kiadeh;
Birjand, Iran, Islamic Republic of
106
Posters - August 23
458
P5.02.07 - Crucial role of basal p53 in attenuation of inflammation and fibrosis in hereditary glomerular nephritis,
Alport syndrome
Ryosuke Fukuda, K. Koyama, T. Koga, Y. Kai, K. Omachi, K. Motomura, M.A. Suico, T. Shuto, H. Kai;
Kumamoto, Japan
459
P5.02.08 - Intramuscular administration of MMP-8 adenoviral vector reduces inflammation up-grade induced by vector
delivery and allows prevention of liver fibrosis
Jesus García-Bañuelos, E. Oceguera-Contreras, D. Gordillo-Bastidas, A. Sandoval-Rodríguez, B. Bastidas-Ramírez, J. González-Cuevas,
J. Macias-Barragan, B. Gómez-Meda, J. Armendariz-Borunda;
Guadalajara, Mexico
460
P5.02.09 - Mac-3 positive and enlarged foamy macrophage as an effector in radiation-induced pulmonary fibrosis
H. Park, Sung-Kee Jo, U. Jung;
Jeongeup-si, Korea, Republic of
461
P5.02.10 - Mild electrical stimulation with heat shock ameliorates nephritis and proteinuria in mouse model of X-linked alport
syndrome
Yukari Kai, T. Koga, R. Fukuda, S. Morino-Koga, M.A. Suico, K. Koyama, T. Sato, T. Shuto, H. Kai;
Kumamoto, Japan
462
P5.02.11 - Interleukin-17 isoforms are differentially expressed in the skin of Systemic Sclerosis and Morphea patients
compared to healthy skin
Paola Adele Lonati, N. Brembilla, L. Fontao, E. Laffitte, G. Kaya, P. Meroni, C. Chizzolini;
Milan, Italy
463
P5.02.12 - IL-33 precursor drives inflammation without engaging T1/ST2 or Th2
Irina G. Luzina, V. Lockatell, N.W. Todd, S.P. Atamas;
Baltimore, United States
464
P5.02.13 - 5-methyl-1-phenyl-2-(1H)-pyridone reveals immunomodulatory anti-fibrotic effects associated to antioxidant
system activation in primary culture of human Hepatic Stellate Cells
Jose Macias-Barragan, A. Caligiuri, E. Novo, M. Parola, J. Vera-Cruz, J. García-Bañuelos, S. Lucano-Landeros, M. Pinzani,
J. Armendáriz-Borunda;
Ameca, Mexico
465
P5.02.14 - Phenotypical characterization of the peripheral blood T cells in celiac disease patients
Mohsen Masjedi, H. Hossein Nataj Arab, M. Emami, F. AlSahebfosoul, M. Mokhtari;
Isfahan, Iran, Islamic Republic of
466
P5.02.15 - GSK-3: a key mediator of the balance between matrix-metalloproteinases (MMPs) and their tissue inhibitors
(TIMPs) in bleomycin (BLM) - induced pulmonary fibrosis
Barbara Montini, F. Cinetto, M. Gnoato, N. Compagno, C. Gattazzo, F. Piazza, F. Lunardi, F. Calabrese, G. Semenzato, C. Agostini;
Padova, Italy
467
P5.02.16 - Genes affecting MMP expression are down-regulated in patients with COPD and bronchial asthma
Zdenka Navratilova, T. Krsjakova, E. Novosadova, J. Zatloukal, V. Kolek, M. Petrek;
Olomouc, Czech Republic
468
P5.02.17 - Altered response of tympanosclerotic fibroblasts to interacting mast cells: implication for tissue remodeling
Tadeusz K. Pawelczyk, M. Sakowicz-Burkiewicz, J. Kuczkowski;
Gdansk, Poland
469
P5.02.18 - The crosstalk of kinin receptors on Experimental Focal and Segmental Glomerulosclerosis
Rafael L. Pereira, R. Felizardo, M. Cenedeze, M. Hiyane, R.C. Silva, C.F. Aguiar, J.B. Pesquero, R.C. Araújo, A.P. Silva, N.O.S. Câmara;
São Paulo, Brazil
470
P5.02.19 - M2 muscarinic acetylcholine receptor modulates rat airway smooth muscle cell Proliferation
Fabiola A. Placeres-Uray;
Caracas, Venezuela, Bolivarian Republic of
471
P5.02.20 - Periostin modulates the course of IL-13 dependent chronic inflammation and liver fibrosis
Thirumalai R. Ramalingam, A. Talley, M.M. Mentink-Kane, T.A. Wynn;
Bethesda, United States
472
P5.02.21 - In vivo multi-photon molecular imaging technique visualizes immune and inflammatory cell cross-talks in
metabolic diseases
Nishimura Satoshi, M. Nagasaki;
Tokyo, Japan
473
P5.02.22 - Metformin modulates lipolysis and inflammation through the modulation of T cell priming in obese-induced
Type II diabetic mice
Seulmee Shin, B. Hyun, A. Lee, S. Lee, H. Kong, S. Han, Y. Song, K. Kim;
Seoul, Korea, Republic of
474
P5.02.24 - High-mobility group box 1, actively secreted by cardiac fibroblasts, might be a novel culprit of myocardial
contractility dysfunction and cardiac collagen deposition
Zhaoliang Su, J. Yin, R. Ma, T. Wang, F. Kong, H. Shen, H. Xu;
Zhenjiang, China
475
P5.02.25 - Knee injury with concomitant osteochondral fracture is associated with increased synovial fluid concentrations
of SPARC, IL-8 and TNF-α
Per Swärd, A. Struglics, M. Englund, H. Roos, R. Frobell;
Lund, Sweden
107
Posters - August 23
476
P5.02.26 - Implication of antigen-driven mechanisms in the pathogenesis of interstitial pneumonia associated with
polymyositis
Akira Takeda, Y. Fukushima, T. Matsutani, Y. Haji, R. Rokutanda, Y. Suyama, M. Kishimoto, K. Yamaguchi, M. Okada;
Nasushiobara, Japan
477
P5.02.27 - Intrinsic epithelial activation in Primary Sjogren’s syndrome: Evidence of significantly reduced constitutive
expression of PPAR-gamma in cultured non-neoplastic salivary gland epithelial cell lines
Aigli G. Vakrakou, A. Kapogiannatou, V. Gourzi, E.K. Kapsogeorgou, M.N. Manoussakis;
Athens, Greece
478
P5.02.28 - IL28B polymorphisms may be associated with Chlamydia pneumoniae infection in patients with cardiac disease
Antonio C. Vallinoto, B. Brasil Santana, N. Almeida, R. Bezerra Hermes, R. Ishak, M.O.G. Ishak;
Belem, Brazil
479
P5.02.29 - Accumulation of tolerogenic cells at the site of granulomatous foreign-body reaction
Dragana Vucevic, S. Vasilijic, J. Djokic, B. Bozic, I. Majstorovic, S. Tomic, M. Vasiljevska, B. Draskovic-Pavlovic, M. Colic;
Belgrade, Serbia
480
P5.02.30 - EBP-1 specific T cell responses correlate with liver damage in chronic hepatitis B
Li Wang, l. Jiang, X. Chen, X. Chen, Y. Wu;
Chongqing, China
481
P5.02.31 - Human kidney proximal tubule epithelial cells (PTEC) modulate autologous immune responses by contact
dependent mechanisms
Ray Wilkinson, S. Sampangi, A. Kassianos, X. Wang, H. Healy;
Brisbane, Australia
482
P5.02.32 - Systemic inflammation in patients with end-stage renal disease (ESRD) receiving different types of renal replacement
therapy
L.V. Solomatina, Iuliia Zhuravleva, E. Panshina, E. Gusev;
Ekaterinburg, Russian Federation
P5.08 ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASES
Session Time: Friday, August 23, 13:20 -15:00
483
P5.08.01 - Elevated vascular adhesion protein-1 (VAP-1) levels in cardiovascular disease events
Kristiina Aalto, M. Maksimow, S. Jalkanen, V. Salomaa, M. Salmi;
Turku, Finland
484
P5.08.02 - ROS and RNS signaling in cardiovascular diseases: Could antioxidants be useful?
Igor B. Afanas’ev;
Porto, Portugal
485
P5.08.03 - Serum amyloid A stimulates macrophage foam cell formation via formyl peptide receptor 2
Yoe-Sik Bae, H. Lee, S. Kim, S. Baek, J. Choi, K. Cho, E. Cho, B.A. Zabel;
Suwon, Korea, Republic of
486
P5.08.05 - Elevated CD14++CD16- monocytes predict cardiovascular events
K.E. Berg, I. Ljungcrantz, L. Andersson, C. Bryngelsson, B. Hedblad, G.N. Fredrikson, J. Nilsson, Harry Björkbacka;
Malmö, Sweden
487
P5.08.06 - T-helper 2 immunity is associated with reduced risk of myocardial infarction and stroke
L. Andersson, D. Engelbertsen, I. Ljungcrantz, M. Wigren, B. Hedblad, J. Nilsson, Harry Björkbacka;
Malmö, Sweden
488
P5.08.07 - Identification of NOD like receptors (NLRs) in human atheroma lesions
R.T.D. Oliveira, M.F. Mineiro, R.M. Silva, M.R. Paiao, R.L. Mamoni, F.H. Menezes, Maria H.S.L. Blotta;
Campinas, Brazil
489
P5.08.08 - Oral anti-CD3 antibody treatment ameliorates mHSP65-induced atherosclerosis
C. Grundtman, Maja A. Buszko, H. Dietrich, G. Wick;
Innsbruck, Austria
490
P5.08.09 - Study of endothelial progenitor cells as a non-invasive strategy to detect endothelial alterations in patients
with idiopathic thromboembolism
Francesca Calcaterra, S. Rambaldini, C. Lodigiani, D. Mavilio, S. Della Bella;
Rozzano, Italy
491
P5.08.10 - A murine model of atherosclerosis, frequency and phenotype of the B cell subsets involved
Diana Castaño, H. Rincón-Arévalo, J. Villa-Pulgarín, J.R. Ramírez-Pineda, G. Vásquez, L.M. Yassín;
Medellin, Colombia
492
P5.08.11 - Specific oligoclonal T-cell recruitment within epicardial adipose tissue of patients with acute coronary
syndrome: evidence for a local, immune-mediated, pathogenetic mechanism
Gabriele Di Sante, G. Liuzzo, A. Severino, V. Pazzano, D. Pedicino, S. Tziopulos, N. Luciani, F. Glieca, F. Ria, F. Crea;
Rome, Italy
493
P5.08.12 - Kinins promote aortic aneurysm through stimulation of neutrophil activation via the B2 receptor
Tammy Dougan, C.S. Moran, C. Rush, R. Jose, L. Woodward, J. Golledge;
Townsville, Australia
494
P5.08.13 - Increased levels of MDA-modified collagen type IV in symptomatic lesions - a possible marker of unstable lesions
Pontus Dunér, H. Grufman, A. Edsfeldt, F. To, J. Nilsson, I. Goncalves, E. Bengtsson;
Malmö, Sweden
108
Posters - August 23
495
P5.08.14 - Myd88 signalling in CD4+ T cells promotes atherosclerosis and Th17 responses
Daniel Engelbertsen, M. Wigren, H. Björkbacka, J. Nilsson, E. Bengtsson;
Malmö, Sweden
496
P5.08.15 - Loss of B-cell function in MRas- knock-out mouse and reduced macrophage infiltration in atherosclerotic
plaques at the aortic root
Jennifer Freyer, M. Behrensen, Z. Aherrahrou, J.F.P. Berbèe, H. Schunkert, J. Erdmann;
Lübeck, Germany
497
P5.08.16 - Human carotid atherosclerotic plaques with high Interleukin 16 mRNA levels are associated with less clinical
symptoms
Caitríona Grönberg, M. Nitulescu, L. Hollender, A. Persson, M. Nilsson, G. Nordin Fredrikson, J. Nilsson, H. Björkacka;
Malmö, Sweden
498
P5.08.18 - IgE and eosinophilia levels in peripheral blood of patients with cardiovascular disease
Morteza Hosseinzadeh, A. Khosravi, A. Delpisheh, S. Safari, R. Kafashi;
Tehran, Iran, Islamic Republic of
499
P5.08.19 - Immunotherapy with tolerogenic Apolipoprotein B-100-loaded dendritic cells inhibits progression of
atherosclerosis in hypercholesterolemic mice
Daniel K. Johansson, D. Ketelhuth, A. Hermansson, M. Josefa Forteza de los Reyes, A. Ismail, K. Lindner, G.K. Hansson;
Stockholm, Sweden
500
P5.08.20 - Apolipoprotein B100 danger-associated signal 1 (ApoBDS-1) is a potent platelet agonist that triggers
procoagulant and proinflammatory responses
A. Assinger, Y. Wang, L.M. Butler, G.K. Hansson, Z. Yan, C. Söderberg-Nauclér, Daniel F.J. Ketelhuth;
Stockholm, Sweden
501
P5.08.21 - Study the correlation of haptoglobin phenotypes in acute heart attack patients
Hossein A. Khazaei;
Zahedan, Iran, Islamic Republic of
502
P5.08.22 - Sublingual vaccination with Porphyromonas gingivalis GroEL elicits protective immunity against atherosclerosis
M. Hagiwara, Tomoko Kurita-Ochiai, R. Kobayashi, T. Hashizume-Takizawa, M. Yamamoto;
Matsudo, Chiba, Japan
503
P5.08.23 - IL-25 treatment inhibits atherosclerosis development in ApoE deficient mice
Polyxeni T. Mantani, P. Dunér, E. Bengtsson, R. Alm, I. Söderberg, L. Sundius, F. To, J. Nilsson, H. Björkbacka, G. Nordin Fredrikson;
Malmö, Sweden
504
P5.08.24 - Soluble Fc RIIIaMφ levels in plasma correlate with stenosis rate in patients examined with carotid ultrasonography
Midori Masuda, K. Kouno, N. Nishimura, H. Masaki, T. Yokoi, Y. Komiyama, T. Iwasaka, H. Takahashi;
Osaka, Japan
505
P5.08.25 - Atherosclerosis in rats after immunization with human native low-density lipoproteins
Igor Menshikov, K. Fomina, L. Beduleva;
Izhevsk, Russian Federation
506
P5.08.26 - Susceptibility to ischemic stroke and HPA4/Annexin5 polymorphisms
Imen Mezni, M. Jeljeli, T. Dhaouadi, S. Younes, N. Benali, I. Bannour, I. Sfar, A. Boughammoura, A. Bahloul, M. Makhlouf;
Tunis, Tunisia
507
P5.08.27 - Inhibition of IL-27 attenuates atherosclerosis by inducing regulatory T cells
Ornelia H. Ramos, P.J. van Santbrink, I. Bot, M. Bot, R. van der Sluis, M. ter Borg, S.C. de Jager, J. Kuiper;
Leiden, Netherlands
508
P5.08.28 - Splenectomy increases atherosclerotic lesions in apolipoprotein E deficient mice
Alice B. Rezende, N.N. Neto, L.R. Fernandes, A.C. Ribeiro, J.I. Alvarez-Leite, H.C. Teixeira;
Juiz de Fora, Brazil
509
P5.08.29 - IL-22 deficiency induces vascular remodeling and alterations in immune cell populations after carotid injury
Sara Rattik, G. Roos, I. Söderberg, H. Björkbacka, G. Nordin-Fredrikson, A. Hultgårdh-Nilsson, J. Nilsson;
Malmö, Sweden
510
P5.08.30 - The role of anti-apolipoprotein A1 autoantibodies in cardiovascular risk stratification
Priscila C. Teixeira, P. Ferber, A. Ducret, S. Pagano, H. Gaertner, O. Hartley, H. Langen, N. Vuilleumier, P. Cutler;
Basel, Switzerland
511
P5.08.31 - Platelet-derived microparticles may contribute to the thrombotic tendency in systemic lupus erythematosus by
both procoagulant and immune-mediated mechanisms
Konstantinos Tselios, P. Klonizakis, S. Gerou, D. Bougiouklis, A. Sarantopoulos, I. Gkougkourelas, P. Boura;
Thessaloniki, Greece
512
P5.08.32 - GDF-15, ST-2 and Galectin-3 plasma levels and their potential relations in patients with coronary artery disease
Elena Vianello, G. Dogliotti, E. Dozio, M.M. Corsi Romanelli;
Milan, Italy
513
P5.08.33 - Aggravation of atherosclerosis by MHC class II antigen deficiency is associated with a loss of regulatory T cells
but is independent on IL-10
Maria Wigren, S. Rattik, H. Björkbacka, G. Nordin Fredrikson, J. Nilsson;
Malmö, Sweden
109
Posters - August 23
P5.12 RHEUMATOID ARTHRITIS AND OTHER INFLAMMATORY JOINT DISEASES
Session Time: Friday, August 23, 13:20 -15:00
514
P5.12.01 - The investigation of Anti Centromer Antibodies in Autoimmune Diseases
B. Karaayak Uzun, A. Sener, E. Tarhan, Ilhan Afsar, S. Kaya;
Izmir, Turkey
515
P5.12.02 - Oxidative stress or NK cells: The combination is getting deadlier for rheumatoid arthritis
Ashish Aggarwal, A. Sharma, A. Bhatnagar;
Chandigarh, India
516
P5.12.03 - B-cell activating factor versus biopsy in lupus nephritis among Egyptians systemic lupus patients
Shereen Algergawy, E. Abd Algwad, r. zakaria;
Benha, Egypt
517
P5.12.05 - Anti-Interleukin-6 and anti-TNF-alpha treatment do not have a negative impact on the immune response against
CMV, but disease status influences the balance and the cytokine profile in juvenile idiopathic arthritis patients (JIA)
Giovanni Almanzar, R. Trippen, K. Sustal, K. Höfner, M. Prelog;
Würzburg, Germany
518
P5.12.06 - IL-1β membrane-bound receptors in health and in rheumatoid arthritis
Alina Alshevskaya, F. Vasiliev, J. Lopatnikova, N. Shkaruba, O. Chumasova, A. Sizikov, S. Sennikov;
Novosibirsk, Russian Federation
519
P5.12.08 - Performance of anti-CCP3 IgG/IgA (CCP3.1) test compared to anti-CCP2 IgG test
Mounira Benidir, H. Amroun, S.S. Salah, G. Hamadi, O. Rendja, N. Attal, M.C. Abbadi;
Algiers, Algeria
520
P5.12.09 - Rheumatoid arthritis: early thymic involution or increased proliferation rate?
Elena A. Blinova, V.S. Kozhevnikov, A.E. Sizikov, V.A. Kozlov;
Novosibirsk, Russian Federation
521
P5.12.10 - TNF receptor function is dispensable for generation of CD23+ CD21-high B cells in inflamed nodes
I. Kuzin, E. Schwarz, Andrea Bottaro;
Camden, United States
522
P5.12.11 - Biomarker of inflammation in juvenile idiopathic Arthritis (JIA)
Juergen Brunner, T. Giner, G. Weiss, D. Fuchs;
Innsbruck, Austria
523
P5.12.12 - APRIL, a TNF family member, can be a predictor of resistance to antigen-induced arthritis in mice
Adriana Carvalho, R. Vasconcellos, C.E.C. Pinto, M. Hahne, W. Savino, D.M.S. Villa-Verde;
Rio de Janero, Brazil
524
P5.12.13 - Optimization of “in vitro” culture conditions for human arthritis rheumatoid synovial fibroblasts
Claudia Casnici, D. Lattuada, K. Crotta, O. Marelli;
Milan, Italy
525
P5.12.14 - S100A8 plays an anti-inflammatory role in collagen-induced arthritis
Annabelle Cesaro, N. Pagé, M.R. Tardif, A. Al-Shami, T. Oravecz, P.A. Tessier;
Quebec, Canada
526
P5.12.15 - ERAP1 gene polymorphisms influence the risk of Spondyloarthritis in HLA-B27 positive Romanians
M. Cherciu, L.O. Popa, M. Bojinca, M.I. Dutescu, V. Bojinca, R. Caisan, C. Bara, Olivia M. Popa;
Bucharest, Romania
527
P5.12.16 - TWEAK Promotes Osteoclastogenesis in Rheumatoid Arthritis
Mi-La Cho, J. Park, M. Lim, S. Kwok, J. Jhun, S. Park;
Seoul, Korea, Republic of
528
P5.12.17 - CD8+ T cell reactivity against apoptotic self-epitopes in rheumatoid arthritis patients treated with etanercept
Alessandra Citro, R. Scrivo, H. Martini, S. Piconese, F. Miranda, V. Barnaba, G. Valesini;
Rome, Italy
529
P5.12.18 - The effect of the Slc11a1 gene on pristane-induced arthritis chronic phase
Mara A. Correa, T. Canhamero, J.L. Guerra, A. Borrego, J.R. Jensen, W.H. Cabrera, N. Starobinas, O.G. Ribeiro, O.C. Ibanez,
M. De Franco;
São Paulo, Brazil
530
P5.12.19 - Role of the expression CCR7+CCR5+ CX3CR1+ CD95 +/- in the peripheral blood lymphocytes in systemic lupus
erythematous patients
Laila A. Damiati, A.M. Al-Dahlawi, M.F. El-Shal, S.M. Bahlas;
Jeddah, Saudi Arabia
531
P5.12.20 - Role of CCRL2 in the pathogenesis of mouse experimental arthritis
Annalisa Del Prete, S. Gonzalvo-Feo, L. Wang, C. Mazzon, E. Scanziani, A. Vecchi, S. Sozzani;
Rozzano (MI), Italy
532
P5.12.21 - Collagen-specific TCR Repertoire usage in RA and cytokine secretion
Gabriele Di Sante, A. Fedele, B. Tolusso, C. Nicolò, A. Carbonella, S. Bosello, E. Gremese, S. Canestri, F. Ria, G. Ferraccioli;
Rome, Italy
533
P5.12.22 - Clinical and immunological characteristics of Senegalese patients with rheumatoid arthritis (RA)diagnosed
according to American College of Rhumatology criteria of 1987
Mamadou L. Diokh, M. Sylla Niang, B. Mbengue, A.C. Ndao Mbengue, F. Sow Faye, S. Ndongo, T.N. Dièye, A. Dièye;
Dakar, Senegal
110
Posters - August 23
534
P5.12.23 - T676G polymorphims of the TNF receptor type II is associated with ankylosing spondylitis
Ma D.J. Durán-Avelar, J. Gutiérrez-Franco, N. Vibanco-Pérez, F.D. Trejo-Ramírez, S. Peña-Virgen, J.F. Zambrano-Zaragoza;
Tepic, Mexico
535
P5.12.24 - Cytokines in relation to autoantibodies before onset of symptoms in systemic lupus erythematosus (SLE)
Catharina Eriksson, S. Rantapää Dahlqvist;
Umeå, Sweden
536
P5.12.25 - Identification of myeloid dendritic cells and plasmacytoid dendritic cells in the peripheral blood of rheumatoid
arthritis
Svetlana A. Falaleeva, V. Kurilin, N. Shkaruba, O. Chumasova, A. Sizikov, S. Sennikov;
Novosibirsk, Russian Federation
537
P5.12.26 - Extended characterization of human chondrocytes for establishment of co-culture systems with synovial
fibroblasts under different culture conditions in the context of Rheumatoid Arthritis
S. Möller, P. Kern, H. Joos, R. Brenner, Jens A.A. Fischer;
Penzberg, Germany
538
P5.12.27 - Interplay of myeloid cells and synovial fibroblast boosts the inflammatory response
P. Kern, B. Schwarz, M. Galm, L. Pradel, Jens A.A. Fischer;
Penzberg, Germany
539
P5.12.28 - The candidate rheumatoid arthritis autoantigen aggrecan enhance IL-9 response in peripheral blood of
Rheumatoid Arthritis’ patients
Giuseppina Giardina;
Palermo, Italy
540
P5.12.29 - Certolizumab Pegol in Rheumatoid Arthritis. Follow-up in latinoamerican experience
Renato Antonio Guzman Moreno, G. Roa Montes, J. Cordoba, W. Rodriguez, W. Otero;
Bogota, Colombia
541
P5.12.30 - Chondrocytes as mediators of citrullination and humoral immunity to citrullinated type II collagen in Rheumatoid
Arthritis
Sabrina Haag, N. Schneider, D.E. Mason, J. Tuncel, I.E. Andersson, E.C. Peters, H. Burkhardt, R. Holmdahl;
Stockholm, Sweden
542
P5.12.31 - TNF-alpha and IL1-beta contribute to the increased severity of serum-induced arthritis in NOX2 deficient mice
Ya-Fang Huang, P.A. Nigrovic, C. Shieh;
Tainan, Taiwan
543
P5.12.32 - TNFα-induced adipose-related protein (TIARP) functions as a negative regulator of inflammatory process in arthritis
Asuka Inoue, I. Matsumoto, N. Umeda, Y. Tanaka, C. Takai, S. Takahashi, T. Sumida;
Tsukuba, Ibaraki, Japan
544
P5.12.33 - Increase of PADI4 in the joints and anti-CCP antibody in the sera of a murine model for rheumatoid arthritis
before the clinical onset of arthritis
Katsuhiko Ishihara, A. Yahagi, T. Saika, H. Igarashi;
Kurashiki, Japan
545
P5.12.34 - Promoter polymorphisms of the TNFα (-308 G/A) and IL-6 (-174G/C) genes predict therapeutic response to
etanercept
Ivan R. Jancic, N. Arsenovic -Ranin, M. Sefik-Bukilica, S. Zivojinovic , N. Damjanov, V. Spasovski, S. Srzenti , B. Stankovic, S. Pavlovic ;
Belgrade, Serbia
546
P5.12.36 - Dendritic Cell ImmunoReceptor (DCIR) is a negative regulator in balancing bone metabolism
Tomonori Kaifu, T. Maruhashi, G. Ma, R. Yabe, A. Seno, Y. Iwakura;
Noda, Japan
547
P5.12.37 - Immunomodulatory role of Fasiola gigantica derived somatic antigens
Yasir A. Khan, S. Umar, M.A.H. Khan, P.A.A. Shareef, R. Ullah, A. Rehman, S.M.A. Abidi;
Aligarh, India
548
P5.12.38 - Fibrinogen induced inhibition of osteoclastogenesis is reversed by citrullination of fibrinogen by peptidylarginine
deiminase
Ji S. Kim, M.K. Choi, J.Y. Choi, J.Y. Kim, J.S. Song, H.J. Kim, K.H. Park-Min, L.B. Ivashkiv, Y.W. Song, E.Y. Lee;
Seoul, Korea, Korea, Republic of
549
P5.12.39 - Caspase-5 inhibition suppresses inflammatory responses in fibroblast-like synoviocytes with rheumatoid arthritis
Yong-Jin Kwon, J. Song, Y. Park, S. Lee, M. Park;
Seoul, Korea, Republic of
550
P5.12.40 - Significant reduction of the Cia25/Pia42 interval, a new arthritis severity and joint damage locus that regulates
the invasive properties of synovial fibroblasts. Cia25/Pia42
M. Brenner, Teresina Laragione, P.S. Gulko;
Manhasset, United States
551
P5.12.41 - The arthritis severity locus Cia4 is an early regulator of IL-6, IL-1b and genes implicated in NFkB activation in
synovial tissues of rats with pristane-induced arthritis
M. Brenner, Teresina Laragione, P.S. Gulko;
Manhasset, United States
552
P5.12.43 - TRPV2 is new suppressor of arthritis severity and joint damage
Teresina Laragione, C. Beeton, P.S. Gulko;
Manhasset, United States
111
Posters - August 23
553
P5.12.42 - The nuclear receptor NR1D1 suppresses the invasive properties of synovial fibroblasts from rheumatoid arthritis
Teresina Laragione, M. Brenner, P.S. Gulko;
Manhasset, United States
554
P5.12.44 - Decreased heart rate variability in patients with Behcet’s disease
JoungWook Lee;
Busan, Korea, Republic of
555
P5.12.46 - Antibodies against TIF1gamma in cancer associated myositis precede cancer symptoms and persist after cancer removal
Ingrid E. Lundberg, L. Dani, M. Dastmalchi, N. Martínez, M. Labrador-Horrillo, A. Selva O’Callaghan;
Stockholm, Sweden
556
P5.12.47 - Anti-Saccharomyces cerevisiae antibodies in rheumatoid arthritis patients
W. Sakly, A. Mankai, W. Manoubi, Ibtsem Ghedira;
Tunis, Tunisia
557
P5.12.48 - Anti-Saccharomyces cerevisiae antibodies in patients with systemic lupus erythematosus
A. Mankai, W. Sakly, Y. Thabet, A. Achour, W. Manoubi, Ibtsem Ghedira;
Tunis, Tunisia
558
P5.12.49 - MiRNA expression profile of peripheral blood mononuclear cells from RA patients and their relationship with
anti-TNF therapy
Pier Luigi Meroni, M. Raimondo, M. Borghi, M. Mirolo, F. Pregnolato, F. Ambrogi, E. Biganzoli, M. Locati;
Milan, Italy
559
P5.12.50 - Podoplanin is upregulated at the Th17-mediated inflammation in SKG arthritic mice
Yoshiaki Miyamoto, H. Uga, M. Kadowaki, M. Ikeda, H. Kurata;
Kobe, Japan
560
P5.12.51 - Allelic expression of 89G/A, 90T/C and 92G/C PADI4 polymorphisms in rheumatoid arthritis
Salvador Muñoz-Barrios, L.I. Angel-Chávez, C.A. Palafox-Sánchez, E. Oregón-Romero, I. Parra-Rojas, Z. Reyes-Castillo,
M. Vázquez-Villamar, J.F. Muñoz-Valle;
Guadalajara, Jalisco, Mexico
561
P5.12.52 - Evaluation of anti-PADI4 antibodies in rheumatoid arthritis: Association with clinical parameters
Salvador Muñoz-Barrios, Z. Reyes-Castillo, M. Vázquez-Villamar, C.A. Palafox-Sánchez, E. Oregón-Romero, I. Parra-Rojas,
L.I. Angel-Chávez, M.O. Guzmán-Ornelas, R.E. Navarro-Hernández, J.F. Muñoz-Valle;
Guadalajara, Jalisco, Mexico
562
P5.12.53 - Study of IGA1 O-Glycosylation in a multi-ethnic population of IGA Nephropathy patients in Kwazulu Natal,
South Africa
Prishani Nansook, A.G. Assounga;
Durban, South Africa
563
P5.12.54 - The mesenchymal stem cell supernatant therapy improves symptoms of collagen-induced arthritis in rats
Maryam Nezafat Firizi, T. Mousavi, E. Entezami;
Tehran, Iran, Islamic Republic of
564
P5.12.55 - A monoclonal CCP-antibody derived from RA patients binds to several citrullinated antigens in the human
cellular components
Tatsuhiko Ozawa, R. Tuda, E. Kobayashi, H. Hounoki, K. Shinoda, H. Taki, K. Tobe, H. Kishi, A. Muraguchi;
Toyama, Japan
565
P5.12.56 - Complement Regulatory Protein MCP; CD46 in Rheumatoid Arthritis
Roma Pahwa, U. Kumar, N. Das;
New Delhi, India
566
P5.12.57 - Halofuginone ameliorates autoimmune arthritis by regulation the balance between Th17 and Tregs and the
inhibition of osteoclastogenesis
Sung-Hwan Park, M. Park, E. Park, D. Lee, S. Baek, E. Yang, J. Woo, S. Kwok, H. Kim, M. Cho;
Seoul, Korea, Republic of
567
P5.12.58 - Number of activated cytotoxic T-lymphocytes and natural killers in children with juvenile arthritis.
Irina A. Pashnina;
Ekaterinburg, Russian Federation
568
P5.12.59 - Antibodies to citrullinated peptide in children with juvenile arthritis
Irina A. Pashnina, I.M. Krivolapova;
Ekaterinburg, Russian Federation
569
P5.12.60 - The number of B-cells subpopulations and level of autoantibodies in children with juvenile arthritis
Irina A. Pashnina, I.M. Krivolapova;
Ekaterinburg, Russian Federation
570
P5.12.61 - IL12B gene haplotype influences the risk of ankylosing spondylitis in Romanians
Olivia Mihaela Popa, E. Kriegova, L. Popa, M. Cherciu, M.I. Dutescu, M. Bojinca, V. Bojinca, P. Schneiderova, C. Bara, M. Petrek;
Bucharest, Romania
571
P5.12.63 - Angiogenic T cell depletion in Rheumatoid Arthritis patients
Javier Rodriguez-Carrio, M. Alperi-López, P. López, S. Alonso-Castro, F.J. Ballina-García, A. Suárez;
Oviedo, Spain
572
P5.12.64 - The +1858C>T/-1123G>C PTPN22 gen haplotypes and linkage disequilibrium in rheumatoid arthritis patients from
Western Mexico
Yeniley Ruiz-Noa, J.R. Padilla-Gutierrez, C.A. Palafox-Sánchez, Y. Valle, E. Oregón-Romero, G.E. Martínez-Bonilla, J.F. Muñoz-Valle;
Guadalajara, Jalisco, Mexico
112
Posters - August 23
573
P5.12.65 - Anti-TNF treatment limits the prothrombotic features of platelets and neutrophils in rheumatoid arthritis
M. Baldini, N. Maugeri, P. Rovere-Querini, E. Baldissera, G. Peretti, Maria G. Sabbadini, A.A. Manfredi;
Milan, Italy
574
P5.12.66 - Comparative significance of YKL-40 in different types of arthritis
M. Kazakova, A. Batalov, N. Mateva, Z. Kolarov, Victoria Sarafian;
Plovdiv, Bulgaria
575
P5.12.67 - A positive feedback mechanism of IL-6 through phosphorylated and unphosphorylated STAT3 in inflammatory
arthritis
Mamdouh A.K. Sedhom, A.G. Pratt, A. Anderson, C. Routledge, J. Chay, J. Isaacs, R. Thomas;
Woolloongabba, QLD, Australia
576
P5.12.68 - Anti-mutated citrullinated vimentin antibodies of IgA isotype during rheumatoid arthritis
H. Ben Hassine, O. Khalifa, H. Ben Fraj, H. Zaglaoui, E. Bouajina, Rim Sghiri;
Sousse, Tunisia
577
P5.12.69 - Genetic susceptibility to rheumatoid arthritis in the Tunisian population: case of PADI4 and REL genes
H. Ben Hassine, R. Zemni, O. Khalifa, H. Zaglaoui, E. Bouajina, F. Slama, J. Boukadida, Rim Sghiri;
Sousse, Tunisia
578
P5.12.07 - Anti-C1q antibodies and systemic lupus erythematosus in the Tunisian population
Hana Ben Hassine, B. Trad, M. Khalifa, N. Idriss, F. Slama, J. Boukadida, R. Sghiri;
Sousse, Tunisia
579
P5.12.70 - The development of antibodies specific for carbamylated protein precedes disease onset in mice with collagen
induced arthritis
Jeroen N. Stoop, B. Liu, J. Shi, D.T.S.L. Jansen, T.W.J. Huizinga, L.A. Trouw, R.E.M. Toes;
Leiden, Netherlands
580
P5.12.71 - Aryl hydrocarbon receptor genetic polymorphisms are associated with Rheumatoid Arthritis
Jhimmy Talbot, R.S. Peres, R.D.R. Oliveira, J.R. Silva, B. Ryffel, T.M. Cunha, J.C. Alves-Filho, E.Y. Liew, P. Louzada-Junior, F.Q. Cunha;
Ribeirao Preto, Brazil
581
P5.12.72 - Premolis semirufa caterpillar-bristles toxic components induce intense cellular and humoral immune responses
I.M. Villas-Boas, R.M. Gonçalves de Andrade, C.C. Squaiella-Baptistão, O.A. Sant’Anna, Denise V. Tambourgi;
São Paulo, Brazil
582
P5.12.73 - Association of the 22 genotype of enhancer HS1,2A of the Ig heavy 3 regulatory region (IgH3 RR-1) with non
response to DMARDS and response to Rituximab in rheumatoid arthritis patients
Barbara Tolusso, E. Gremese, A. Fedele, E. Serone, D. Frezza, M. Gigante, M. Nowik, S. Canestri, C. Di Mario, G. Ferraccioli;
Rome, Italy
583
P5.12.74 - TRAF-6 dependent signaling pathway is essential for TNF-related apoptosis-inducing ligand (TRAIL) induces
osteoclast differentiation
Hwei-Fang Tsai, H. Liao, P. Hsu;
Taipei, Taiwan
584
P5.12.75 - Prevalence of hyperprolactinaemia in antiphospholipid syndrome
Christina Tsigalou, T.G. Konstantinidis, E. Konstantinidou, T. Gioka, N. Galanopoulos, A. Tsirogianni, G. Kampouromiti;
Alexandroupolis, Greece
585
P5.12.76 - Deficiency of prostaglandin D2 receptor CRTH2 deteriorates adjuvant-induced arthritis
Yoshiki Tsubosaka, S. Matsumoto, H. Hirai, M. Hori, M. Nakamura, H. Ozaki, T. Murata;
Bunkyo-ku, Tokyo, Japan
586
P5.12.77 - Association of PD1.1 and PD1.6 polymorphisms with ankylosing spondylitis
Norberto Vibanco-Pérez, J. Gutiérrez-Franco, M.D.J. Durán-Avelar, J.M. Agraz-Cirbian, M.A. Jiménez-Alvarez, S. Peña-Virgen,
J.F. Zambrano-Zaragoza;
Tepic, Mexico
587
P5.12.78 - IL-6R blockade enhances CD39+ efficient regulatory T cells in Rheumatoid Arthritis Patients
Rita Vicente, Y. Pers, P. Portales, J. Quentin, J. Eliaou, C. Jorgensen, P. Louis-Plence;
Montpellier, France
588
P5.12.79 - Prediction rheumatoid arthritis outcome in patients with unclassified arthritis considering enzymatic serum
activity
Marharyta Volkava, A. Kundzer;
Vitebsk, Belarus
589
P5.12.80 - Nuclease IgG activity toward different DNA substrates in patients with rheumatoid arthritis
Marharyta Volkava, A. Kundzer, I. Generalov;
Vitebsk, Belarus
590
P5.12.81 - Reactive arthritis of Yersinia etiology: diagnostics and immunological analysis
Olga P. Vostrikova, O. Portnyagina, A. Dubikov, O.D. Novikova;
Vladivostok, Russian Federation
591
P5.12.82 - The protective role of intracellular reactive oxygen species in autoimmune arthritis
Susann Winter, F. Laulund, M. Hultqvist, R. Holmdahl;
Stockholm, Sweden
592
P5.12.84 - Association of the +49-A/G polymorphism of CTLA-4 in mexican patients with ankylosing spondylitis
Jose F. Zambrano-Zaragoza, J. Gutiérrez-Franco, M.D.J. Durán-Avelar, B.V. de León-Amaral, S. Peña-Virgen, N. Vibanco-Pérez;
Tepic, Mexico
113
Posters - August 23
593
P5.12.85 - Implication for the detection of the joint lesion associated factors and EBV infection in patients with rheumatoid
arthritis
Dong Q. Zhang, X. Chen, R. Xu;
Shanghai, China
594
P5.12.86 - A CD19/CD3 bispecific TandAb, AFM11, facilitates safe and potent killing of CD19+ cells mediated by T-cells
Eugene Zhukovsky, U. Reusch, C. Burkhardt, S. Knackmuss, M. Eser, I. Fucek, K. Ellwanger, F. McAleese, M. Little;
Heidelberg, Germany
P5.17 AUTOINFLAMMATORY DISEASES
Session Time: Friday, August 23, 13:20 -15:00
595
P5.17.01 - The proliferative response to PHA and SEB stimulation of peripheral blood mononuclear cells from oral lichen
planus patients
Tatiana F.A. Almeida, A.M. Mesquita, G.E.B. Alvim-Melo, E. Rocha-Vieira;
Diamantina, Brazil
596
P5.17.03 - Endogenous IFN-γ prevents escalation of normal immunity into a Th17-driven inflammation reminiscent of
systemic juvenile idiopathic arthritis
Anneleen Avau, T. Mitera, S. Put, K. Put, E. Brisse, A. Liston, G. Leclercq, A.D. Billiau, C.H. Wouters, P. Matthys;
Leuven, Belgium
597
P5.17.04 - Risk factors of asthma in preschool children
L. Aghebati Maleki, Behzad Baradaran, j. Majidi, A. Aghebati Maleki, F. Zare Shahneh, F. Zamani;
Tabriz, Iran, Islamic Republic of
598
P5.17.05 - Pertussis toxin- driven IL-1β production is required for highly encephalitogenic GM-CSF+ T cell generation in
EAE pathogenesis
Camilla Basso, F. Ronchi, S. Preite, A. Reboldi, A. Lanzavecchia, F. Sallusto;
Bellinzona, Switzerland
599
P5.17.06 - Expression of Suppressor of Cytokine Signalling (SOCS) 1 and 3 in Behçet’s Disease
Lesley A. Bergmeier, M. Hamedi, E. Hagi-Pavli, G. Warnes, F. Fortune;
London, United Kingdom
600
P5.17.07 - Analysis of neutrophil function in severe and moderately affected Chronic Fatigue Syndrome subjects
S.L. Hardcastle, Ekua W. Brenu, D. Staines, S. Marshall-Gradisnik;
Gold Coast, Australia
601
P5.17.08 - To investigate the roles of IL-12 family cytokines on islet graft rejection and tolerance
Heng Yi Chen, F. Chou, H. Sytwu;
Taipei, Taiwan
602
P5.17.09 - Characterization of tonsil infiltration and gene expression profile of innate sensors in PFAPA Syndrome
Sabrina Chiesa, R. Caorsi, F. Penco, A. Bertoni, S. Borghini, A. Omenetti, A. Sementa, F. Bellora, A. Martini, M. Gattorno;
Genova, Italy
603
P5.17.10 - Autoantibodies characteristics of patients with autoimmune liver disease in Uygur people
Luo De Mei, Z. Jian Mei, S. Gulinaer;
Urumqi, China
604
P5.17.11 - BAFF, κ and λ free light chains, C4d and IgG in serum and relations with peripheral blood lymphocyte
populations in patients with primary Sjögren’s syndrome
Irena Dumalakiene, A. Siaurys, D. Mieliauskaite, I. Butrimiene, D. Characiejus, M. Mauricas, G. Sudzius;
Vilnius, Lithuania
605
P5.17.12 - Antinuclear antibodies without identified antigenic target: what is their diagnostic value?
Sawsan Feki, F. Frikha, Y. Ben Haj Hmida, M. Ben Ayed, O. Abida, Z. Bahloul, H. Masmoudi;
Sfax, Tunisia
606
P5.17.13 - Cyclophosfamide plus Rituximab treatment in a case of plurirefractory cutaneous sarcoidosis with large vessels
vasculitis
Valeria Ferri, N. Compagno, R. Scarpa, M. Gazzola, P. Tartaro, C. Agostini;
Padova, Italy
607
P5.17.14 - CD8+ T cells in the pathogenesis of Systemic Sclerosis
Patrizia Fuschiotti, A. Larregina, J. Ho, C. Feghali-Bostwick, T. Medsger Jr.;
Pittsburgh, United States
608
P5.17.15 - Anti-BPI (bactericidal permeability increasing) in autoimmune vasculitis
Sabiha N. Gadiri, H. Meriche, S. Brougui, A. Guermaz, M. Abbadi;
Annaba, Algeria
609
P5.17.16 - Association of enhanced Tim-3 expression on monocytes with disease activity in systemic lupus erythematosus
B. Liu, X. Liang, C. Ma, Lifen Gao;
Jinan, China
610
P5.17.17 - Effects of Vitamin D on regulatory T cells in lupus patients
Mohsen Ghoryani, H. Reihani, M. Rastin, M. Mahmoudi, M. Sahebari, F. Lavi, F. Faraji, N. Tabasi, S. Zamani, M. Khazaee;
Mashhad, Iran, Islamic Republic of
611
P5.17.18 - Oral changes in Wegener granulomatosis(WG)
Josipa Sanja Gruden Pokupec;
Zagreb, Croatia
114
Posters - August 23
612
P5.17.20 - Dense fine speckled patterned antinuclear antibody in patients with fibromyalgia
Hyun-Sook Kim;
Seoul, Korea, Republic of
613
P5.17.21 - Expression and function of the NLRP3 inflammasome in Behçet’s disease
En Hyung Kim;
Seoul, Korea, Republic of
614
P5.17.22 - The cytokine production of peripheral blood mononuclear cells reflects the autoantibody profile of patients
suffering from type 1 diabetes
Jana Labiková, J. Vceláková, S. Kolousková, K. Stechová;
Prague, Czech Republic
615
P5.17.24 - Accelerated spontaneous apoptosis of neutrophils in patients with familial Mediterranean fever
Gayane Manukyan, A. Martirosyan, G. Hagobyan, R. Aminov, T. Davtyan;
Yerevan, Armenia
616
P5.17.26 - The prevalence of wheezing and its relationship with some environmental factors in children aged 6-7 in Yazd
Mojtaba Mirzaei, M. Mirzaei;
Tehran, Iran, Islamic Republic of
617
P5.17.27 - Psychoneuroimmunologycal study in Cuban in patients with systemic lupus erythematosus
E. Noris- Garcia, M. Lánigan, N. Diaz, I. Corrales, A. Brito, N. Fresneda, D. Barberia, R. Rodríguez, S. Arce, Giselle Penton Rol;
La Havana, Cuba
618
P5.17.28 - CAPS monocytes are highly susceptible to oxidative stress: effects on cytokine secretion, reversal by antioxidants
Patrizia Piccioli, S. Carta, L. Delfino, F. Penco, A. Martini, M. Gattorno, A. Rubartelli;
Genoa, Italy
619
P5.17.29 - Loci associated with N-glycosylation of human IgG show pleiotropy with autoimmune diseases and haematological
cancers
Maja Pucic Bakovic, G. Lauc, J. Huffman, J. Wilson, M. Wuhrer, A. Wright, P. Rudd, C. Hayward, H. Campbell, I. Rudan;
Zagreb, Croatia
620
P5.17.30 - B-cell depletion in neuropsychiatric disease in MRL/lpr mice
Chaim Putterman;
Bronx, United States
621
P5.17.31 - Induction of immunoglobulin G Fc-sialylation is associated with disease remission in CIDP
Isaak Quast, F. Cueni, M.A. Maurer, F. Nimmerjahn, M. Dalakas, J.D. Lünemann;
Zürich, Switzerland
622
P5.17.33 - Antibody profile and their relationship with clinical manifestations in patients with Systemic Lupus Erythematosus
Maryam Rastin, M. Mahmoudi, N. Tabasi, S. Zamani, M. Khazaee, M. Ghoriani, H. Reihani, F. Faraji, F. Lavi;
Mashhad, Iran, Islamic Republic of
623
P5.17.34 - 1,25 Dihydroxy vitamin D modulatory effects in patients with systemic lupus erythematosus
Maryam Rastin, M. Mahmoudi, M. Sahebari, N. Tabasi, S. Zamani, D. Haghmorad, R. Nosratabadi;
Mashhad, Iran, Islamic Republic of
624
P5.17.35 - Effects of Vit D on Th17 cells and related cytokines in lupus erythematosus patients
Hadi Reihani, M. ghoryani, M. Rastin, M. Mahmoudi, M. Sahebari, R. Nosratabadi, F. Faraji, F. Lavi, N. Tabasi, S. Zamani;
Mashhad, Iran, Islamic Republic of
625
P5.17.36 - Disease modeling and drug discovery using induced pluripotent stem cells from CINCA syndrome patients
Megumu Saito;
Kyoto, Japan
626
P5.17.37 - Distribution of peripheral blood lymphocyte populations in patients with primary Sjögren’s syndrome
Gintaras Sudzius, D. Characiejus, D. Mieliauskaite, A. Siaurys, I. Butrimiene, I. Dumalakiene;
Vilnius, Lithuania
627
P5.17.38 - Protease activation receptors - A new link between IgE mediated and non-IgE mediated inflammatory reactions
Shanshan Sun, G. Mackay, A. Lopata;
Townsville, Australia
628
P5.17.39 - Identification of a novel cold-associated autoantigen, heterogeneous nuclear RNP-K, in patients with secondary
Raynaud’s phenomenon by proteomic approach.
Ohkawara Tomoharu, L. Yang, H. Honda, S. Serada, M. Fujimoto, T. Naka;
Osaka, Japan
629
P5.17.40 - Increased levels of IL-17F but not IL-17A in patients with immunosuppressive therapy for autoimmune hepatitis
(AIH).
P. Thomas-Dupont, L.A. Sanchez-Vargas, I.Y. Izaguirre-Hernandez, M. Maldonado-Renteria, A. Torre-Delgadillo, J.M. Remes-Troche,
E. Bravo-Sarmiento, Hector Vivanco-Cid;
Veracruz, Veracruz, Mexico
630
P5.17.41 - Amplification of T cell autoreactivity by OX40/OX40L functional complex on peripheral CD4+ T cells in Graves’
disease and clinical significance
Qin Wang, X. Zhang, Y. Ma, X. Zhang;
Suzhou, China
631
P5.17.42 - Increased frequency of Th17 cells in patients with dermatomyositis
X. Tang, J. Tian, J. Chen, Y. Liu, Shengjun Wang;
Zhenjiang, China
115
Posters - August 23
632
P5.17.43 - Plasma microparticles and LL-37 levels regulate Behcet’s Disease severity
T. Kahraman, Fuat Cem Yagci, I. Gursel;
Ankara, Turkey
6.03 PATHOGENESIS AND IMMUNOINTERVENTION IN DIABETES
Session Time: Friday, August 23, 13:20 -15:00
633
P6.03.01 - B-1 cells produce a insulin-like factor and regulate blood glucose levels in STZ-induced diabetic mice
Anuska M. Alvares, M.C.T. Novo, J.T. Maricato, A. Popi, M. Mariano;
São Paulo, Brazil
634
P6.03.02 - Regulation of inflammasome activation and its implication in diabetes-induced microangiopathies
Babak Baban, F. Lamoke, L. Di Renzo, J. Liu, A. Alvari, M. Bartoli;
Augusta, United States
635
P6.03.03 - Autoimmune Anti-prothrombin Antibodies in Type 1 Diabetes Mellitus
Filiz Bakar, U. Ünlütürk, N. Ba kal, S. Nebio lu;
Ankara, Turkey
636
P6.03.04 - Ursolic acid effect on proinflammatory cytokines in response to diet-induced obesity in rats
Blanca E. Bastidas-Ramírez, A.S. González-Ballesteros, A. López-Vázquez, J.J. García-Bañuelos, A.S. Sandoval-Rodríguez,
J.F. Muñoz-Valle, M.R. Bueno-Topete, S. Del Toro-Arreola, R. Del Angel-Meza, J.S. Armendáriz-Borunda;
Guadalajara, Mexico
637
P6.03.06 - Differential expression of microRNAs in type 1, type 2 and gestational diabetes pinpointed miR-142-5p as
potential biomarker for diabetes mellitus
C.V.A. Collares, A.F. Evangelista, D.J. Xavier, D.M. Rassi, M.C. Foss-Freitas, M.C. Foss, E.T. Sakamoto-Hojo, G.A. Passos, Eduardo A.
Donadi;
RIbeirao Preto, Brazil
638
P6.03.07 - TCRγδ T cells in human type 1 diabetes: evidence or clue?
Gian Maria Giamporcaro, A. Valle, A. Stabilini, M. Battaglia;
Milan, Italy
639
P6.03.08 - Resistance of Diabetes in Aged NOD Mice is Mediated by CD4+CD25+Foxp3+ Regulatory T Cells
Zhiguang Guo, B. Liu, L. Tian, B. Tian, A. Ansarullah, Y. Lu, M. Holstein, B. Deruyter;
Sioux Falls, United States
640
P6.03.09 - The effect of induced hyperglycemia on the expression levels of TLR2 and TLR4 genes in the hippocampus of
male Wistar rats during a time course induction of diabetes type 1
Alireza Haghparast, A. Dehghani Firoozabadi, S. Shojaei, M. Behnam Rasouli, N. Mahdavi Shahri;
Mashhad, Iran, Islamic Republic of
641
P6.03.10 - Appearance of beta cell autoantigen primed CD4+ T cells is synchronous to circulating islet autoantibodies in
early pre-type 1 diabetes
Denise Kuehn, A. Heninger, C. Wilhelm, A. Eugster, S. Dietz, A.G. Ziegler, E. Bonifacio;
Dresden, Germany
642
P6.03.11 - Relationship between BKCa channel and the apoptosis of NIT-1 cells induced by IFN-γ/IL-1β treatment
T. Yu, J. He, S. Huang, H. Zhu, G. Shen, F. Gong, Ping Lei;
Wuhan, China
643
P6.03.12 - Anti-inflammatory and anti-diabetic activities of the methanolic fraction of Centratherum anthelminticum seed
in STZ-nicotinamide-induced type 2 diabetic rat
Chung Yeng Looi, A. Arya, M. Mustafa;
Kuala Lumpur, Malaysia
644
P6.03.13 - Can dietary intervention with whole grain decrease risk of type 2 diabetes by reducing inflammasome assembly and IL1β secretion by circulating human neutrophils?
Rasmus B. Maerkedahl, S.B. Metzdorff, C.B. Nielsen, M. Stenbæk, R.J. Gøbel, M. Kristensen, L. Lauritzen, H. Frøkiær;
Frederiksberg, Denmark
645
P6.03.14 - Carbon monoxide-releasing molecule CORM-A1 attenuates the development of autoimmune diabetes in mice
induced by multiple low doses of streptozotocin
Ivana Nikolic, T. Saksida, I. Stojanovic, F. Nicoletti, S. Stosic-Grujicic;
Belgrade, Serbia
646
P6.03.15 - Activation of Natural Killer T Cells Promotes Th2 Immune Response in Adipose Tissue of Obese Galectin-3
Deficient Mice and Improves Systemic Glucose Homeostasis
Jelena Pantic, N. Pejnovic, I. Jovanovic, G. Radosavljevic, G. Besra, N. Arsenijevic, M. Lukic;
Kragujevac, Serbia
647
P6.03.16 - IL-2 and rapamycin in immunotherapy of type 1 diabetes: friends or foes?
Louis Pérol, A. Baeyens, G. Fourcade, N. Cagnard, W. Carpentier, J. Woytschak, O. Boyman, A. Hartemann, E. Piaggio;
PARIS, France
648
P6.03.17 - Treg CD39+ and Th17 cells in Type 2 Diabetes Mellitus Patients
N. Cortez-Espinosa, S.E. Medellin-Garibay, J.D. Cortes-Garcia, A. Nuñez-Ruiz, R. González-Amaro, Diana P. Portales-Pérez;
San Luis Potosí, Mexico
649
P6.03.18 - Immunohistochemical study of the pancreas of patients with long termed diabetes mellitus type 1
A. Proshchina, Yulia Krivova, V. Barabanov, S. Saveliev;
Moscow, Russian Federation
116
Posters - August 23
650
P6.03.19 - ST2 deficiency enhances diet-induced inflammation in visceral adipose tissue and obesity in mice
Gordana Radosavljevic, N. Pejnovic, J. Pantic, I. Jovanovic, I. Jeftic, N. Jovicic, N. Arsenijevic, M. Lukic;
Kragujevac, Serbia
651
P6.03.20 - Oral administration of L. Lactis secreting hGAD65370-575 and hIL-10 can revert diabetes in recent-onset NOD
mice when combined with low-dose anti-CD3
Sofie Robert, T. Takiishi, k. Van Huynegem, L. Steidler, H. Korf, C. Gysemans, T. Van Belle, P. Rottiers, C. Mathieu;
Leuven, Belgium
652
P6.03.21 - Transfer of type 1 diabetes by bone marrow transplantation
Eleonora Tresoldi, P. Monti, P. Piatti, B. Mfarrej, F. Onida, E. Bosi, M. Battaglia;
Milan, Italy
653
P6.03.22 - Characterization of monoclonal ZnT8-specific antibody
Julia Ustinova, D. Belitskin, E. Juronen, E. Zusinaite, M. Utt, R. Uibo;
Tartu, Estonia
654
P6.03.23 - Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signaling in retinal endothelial cells is enhanced in diabetic
retinopathy
Katrien Van Raemdonck, M.I. Nawaz, M. Gouwy, G. Mohammad, D. Kangave, J. Van Damme, A.M. Abu El-Asrar, S. Struyf;
Leuven, Belgium
655
P6.03.24 - Protein S attenuates streptozotocin-induced diabetes mellitus
Taro Yasuma, C. Gabazza, T. Matsumoto, A. Yasukawa, Y. Matsushima, L. C.G.Ayshwarya, Z. Roeen, M. Toda, Y. Yano, E. Gabazza;
Tsu-city, Japan
656
P6.03.25 - Effects of OPN and its cleavage products on human monocyte differentiation and survival
Maximilian Zeyda, K. Schuch, T.M. Stulnig;
Vienna, Austria
117
Posters - August 24
Panel N°
1.10 INNATE SENSORS
Session Time: Saturday, August 24, 13:20 - 15:00
001
P1.10.01 - TLR4 and DC-SIGN receptors recognized Mycobacterium scrofulaceum promoting semi-activated phenotype on
Bone Marrow Dendritic Cells
M. Cruz, Antonia I. Castillo-Rodal, A. Schcolnik, L. Bonifaz, Y. López-Vidal;
México, Mexico
002
P1.10.02 - NOD2 signaling promotes the Treg/Th17 imbalance and contributes to type 1 diabetes pathogenesis
Frederico R.C. Costa, M.C.S. Françozo, J.S. Silva, D.C. Sartori;
Ribeirão Preto, Brazil
003
P1.10.03 - Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy
I. Stroo, A. Tammaro, F. Blank, L. Butter, N. Claessen, T. Takai, M. Colonna, J. Leemans, S. Florquin, Mark Dessing;
Amsterdam, Netherlands
004
P1.10.04 - A shortcut mechanism of innate immune defense by a solitary PRR
Jeak L. Ding, B. Ho;
Singapore, Singapore
005
P1.10.05 - Orchestration of tissue repair by the humoral pattern recognition molecule PTX3: linking microbe and matrix
recognition
Andrea Doni, M. Sironi, T. Musso, C. Castagnoli, M. Gobbi, S. Valentino, S. Tartari, B. Bottazzi, C. Garlanda, A. Mantovani;
Rozzano, Italy
006
P1.10.06 - Dectin-1 exerts opposing roles in the activation of macrophages from resistant and susceptible mice to
Paracoccidioides brasiliensis infection
Claudia Feriotti, V.L.G. Calich;
São Paulo, Brazil
007
P1.10.07 - Induction of antimicrobial peptides in primary cultures from diabetic foot ulcers with 1,25-dihydroxyvitamin D3
and L-isoleucine
Irma E. Gonzalez, V. Trujillo, A. Montoya, A. Enciso, K. Rincon, E. Avila, B. Rivas, B. Rivas-Santiago;
Zacatecas, Mexico
008
P1.10.08 - Deficient antiviral responses to influenza in primary bronchial epithelial cells of chronic obstructive pulmonary
disease
Alan Hsu, K. Parsons, I. Barr, P. Hansbro, P. Wark;
Newcastle, Australia
009
P1.10.09 - Zinc-Finger Antiviral Protein Mediates RIG-I-Like Receptor-Independent Antiviral Response to Murine Leukemia
Virus
Hanna Lee, J. Komano, T. Saitoh, S. Akira;
Osaka, Japan
010
P1.10.10 - Potential role of caveolin-1 in regulation of immune cell activation
Michaela Maceckova, M. Pekarova;
Brno, Czech Republic
011
P1.10.11 - Unbiased screen to identify novel host factors involved in the innate immune recognition of Streptococcus
pneumoniae
Barbara Maier, H. Stöckl, S. Knapp;
Vienna, Austria
012
P1.10.12 - C-type lectin receptor Mincle recognizes amphiphilic acylglucoside derived from Helicobacter pylori
Masahiro Nagata, M. Shimamura, E. Ishikawa, T. Nabeshima, S. Yamasaki;
Fukuoka, Japan
013
P1.10.13 - Natural IgG is not non-reactive: it plays a vital role in innate immune response
Saswati Panda, J.L. Ding;
Singapore, Singapore
014
P1.10.14 - Antibodies against dengue NS1 and prM proteins increase the sensitivity of dengue diagnosis and differentiate
Japanese encephalitis infection
Gowri Sankar S, S. John Vennison, R. Paramasivan, K. Dhananjeyan, V. Thenmozhi, B. Tyagi;
Tiruchirappalli, India
015
P1.10.15 - Cloning and characterization of cytosolic DNA in tumors
Yujia Shen, S. Gasser;
Singapore, Singapore
016
P1.10.16 - Expression and role of the long pentraxin PTX3 in lymphatic endothelial cells
Marina Sironi, A. Doni, F. Pasqualini, S. Valentino, I. Laface, M. Nebuloni, C. Garlanda, B. Bottazzi, A. Vecchi, A. Mantovani;
Rozzano, Italy
017
P1.10.17 - Inhibition of interferon expression with small interference RNA increases adenoviruses-GFP transduction and
transgene expression in Huh7 cells
Ana A. Sobrevilla Navarro, A.S. Sandoval Rodríguez, J.J. García Bañuelos, P. Sanchez Hernández, L.D. Hernández Ortega,
J. Gaona Bernal, J. Armendáriz Borunda, A.M. Salazar Montes;
Guadalajara Jalisco, Mexico
018
P1.10.18 - ApoH an innate immune sensor and hunter that captures and scavenges infectious pathogens
S. Tigrett, G. Dubois, E. Lucarz, I. Stefas, Francisco Veas;
Montpellier, France
118
Posters - August 24
019
P1.10.19 - DAI (DLM-1/ZBP1) promotes lupus nephritis by activating calcium pathway
Sidong Xiong, W. Zhang, W. Xu;
Suzhou, Jiangsu Province, China
020
P1.10.20 - Functional Analyses of Recombinant Mouse hepcidin-1 in Cell Culture and Animal Model
Yazdani Yaghoub, N. Keyhanvar;
Gorgan, Iran, Islamic Republic of
P1.15 INFLAMMASOME
Session Time: Saturday, August 24, 13:20 - 15:00
021
P1.15.02 - Molecular differences of NLRP3 inflammasome activation in LPS-activated human monocyte-derived macrophage
subtypes
M.M. Budai, J. Danis, Á. Becsei, A. Varga, L. Csernoch, J. T zsér, Szilvia Benkő;
Debrecen, Hungary
022
P1.15.04 - The impact of Butyrate on the NOD-like receptor pyrin domain-containing protein 6 (NLRP6)-inflammasome in
humans
Katja Brunner, M. Enea, S. Holly, K. Nigel, B. Mona;
London, United Kingdom
023
P1.15.05 - Activation of the NLRP3 inflammasome promotes the pathogenic Th1/Th17 responses in type 1 diabetes murine
model
Daniela Carlos, J.N.U. Yaochite, F.R.C. Costa, S.G. Ramos, F.Q. Cunha, D.S. Zamboni, N.O. Camara, J.S. Silva;
Ribeirão Preto, Brazil
024
P1.15.06 - Caspase-1 and MyD88 are involved in adaptive immune response induced by cytosolic flagellin
Thaís B. da Costa, C.L. Freitas, V.M. Gonçalves, K.R. Bortoluci;
São Paulo, Brazil
025
P1.15.07 - A novel, Cyclosporine A (CyA)-sensitive P2RX7 SNP haplotype linked to survival of immature antigen
presenting cells (APC) in autoinflammation
Sarah Dagenbach, A. Altmann, M. Lorenz, H. Hohmann, K. Foehr, E.M. Schneider;
University Hospital Ulm, Germany
026
P1.15.08 - Deregulation of NLRP3 inflammasome is involved in progression of hepatocellular carcinoma
Lihui Han, Q. Wei, K. Mu, T. Li, Y. Zhang, W. Huai, X. Jia;
Jinan, China
027
P1.15.09 - Mistletoe lectin-mediated mmunostimulatory effect implicates the activation of NLRP3 inflammasome
Pushpa Hedge, A. Friboulet, J. Bayry, S.V. Kaveri;
Paris, France
028
P1.15.10 - Fine mapping of the mouse Irm1 locus controlling interleukin-1beta production
J.R. Jensen, A. Galvan, W.H.K. Cabrera, O.G. Ribeiro, M. De Franco, N. Starobinas, R. Piazza, M. Dugo, T.A. Dragani, Olga M. Ibañez;
São Paulo, Brazil
029
P1.15.11 - ASC inflammassome mediates IL-1β production and host resistance to Paracoccidioides brasiliensis
Natalia Ketelut-Carneiro, F.A. Rocha, G.K. Silva, D.S. Zamboni, J.S. Silva;
Ribeirao Preto, Brazil
030
P1.15.12 - ATP-mediated inflammasome activation is efficiently inhibited by acetylcholine
Mira Kuellmar, A. Hecker, S. Wilker, S. Atanasova, A. Zakrzewicz, M. Meixner, A. Kaufmann, W. Kummer, W. Padberg, V. Grau;
Giessen, Germany
031
P1.15.13 - Activation of NLRP3 inflammasome is associated with the progression of Alzheimer’s disease
Francesca La Rosa, M. Saresella, E. Calabrese, I. Marventano, F. Piancone, D. Trabattoni, M. Biasin, M. Clerici;
Milan, Italy
032
P1.15.14 - Cytosolic flagellin induces caspase-1/11-independent lysosomal cathepsins-mediated cell death that correlates
to the control of S. typhimurium
Silvia L. Lage, C.B. Lima, E.P. Amaral, K.C. Matteucci, M.M. Rodrigues, M.R. D’Império-Lima, G.P. Amarante-Mendes, K.R. Bortoluci;
São Paulo, Brazil
033
P1.15.15 - Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein
Ming-Zong Lai, Y. Lo, Y. Huang, Y. Wu, C. Tsai, S. Jiang, H. Shih;
Taipei, Taiwan
034
P1.15.16 - Caspase-1-dependent iNOS activation require NF-κB and acts as a non-redundant effector mechanism agaisnt
S. typhimurium
Carina B. Lima, S.L. Lage, G.P.A. Mendes, K.R. Bortoluci;
São Paulo, Brazil
035
P1.15.17 - NLRP3 inflammasome controls the cellular response to DNA damage during oxidative and genotoxic stress
G. Licandro, H.L. Khor, O. Beretta, J. Lai, H. Derks, P. Ricciardi-Castagnoli, Alessandra Mortellaro;
Singapore, Singapore
036
P1.15.18 - Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation
Ida Paciello, A. Silipo, L. Lembo-Fazio, G. Noel, V. Ciancarella, A. Zychlinsky, A. Molinaro, M. Bernardini;
Rome, Italy
037
P1.15.19 - Molecular mechanisms of caspase-11-mediated NLRP3 inflammasome activation
Vijay Rathinam, S. Kailasan Vanaja, L. Waggoner, A. Sokolovska, C. Becker, L. Stuart, J. Leong, K. Fitzgerald;
Worcester, United States
119
Posters - August 24
038
P1.15.20 - NLRP3-driven IL-1 production by Cryptococcus neoformans infection
Pedro H.V. Saavedra, K.G. Magalhães, M. Capparelli, D.S. Zamboni, A.H. Tavares, A. Casadevall, A.L. Bocca;
Brasilia, Brazil
039
P1.15.21 - Inflammation triggered by oncogene KRas in pancreatic tumor cells
Imran Siddiqui, F. Marchesi, S. Pesce, M. Erreni, A. Mantovani, H.M. Kocher, P. Allavena;
Milan, Italy
040
P1.15.22 - Uric acid-induced NLRP3 inflammasome contribute to diabetic kidney injury
Kim Su-Mi, K. Jeong, S. Lee, T. Lee, C. Ihm, S. Lim, J. Moon;
Seoul, Korea, Republic of
041
P1.15.23 - Transcriptional regulation of the anti-inflammatory NLRP12/Monarch-1 by NF-kB
Sinem Tuncer, C. Camperio, G. Camilli, N. Porciello, E. Piccolella, M. Fiorillo, R. Sorrentino;
Rome, Italy
042
P1.15.24 - The role of autophagy in macrophage-derived foam cells after Salmonella enterica serovar Typhimurium infection
Tzu-Yuan Wang;
Taoyuan, Taiwan
P2.02 NUCLEAR RECEPTORS
Session Time: Saturday, August 24, 13:20 - 15:00
043
P2.02.01 - A comparison of the biological features of prostate cancer with (PSA+,PSMA+) profile according to RKIP
A. B. Jemaa, Y. Bouraoui, S. Sallami, Y. Nouira, R. Oueslati, Mouna Ben Azaiz;
Bizerte, Tunisia
044
P2.02.02 - Matrix metalloproteinase 3 activates NFκB in cell nucleus during Dengue virus infection
Jianfeng Dai;
Suzhou, China
045
P2.02.03 - Tumor inflammatory environment modulates expression of PPAR-γ, inflammasome activation and triggers
prostate cancer cell death in vitro
Rafaela S. Fontenele, N.M. Vasconcelos, B.C. Guido, K.G. Magalhães, J.R. Corrêa;
Brasilia, Brazil
046
P2.02.04 - Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice
Manabu Kinoshita, H. Miyazaki, H. Nakashima, M. Ikarashi, S. Seki;
Tokorozawa, Japan
P2.03 EPIGENETIC CONTROL OF IMMUNE RESPONSES
Session Time: Saturday, August 24, 13:20 - 15:00
047
P2.03.01 - Polycomb repressive complex-1 is critical for peripheral B cell differentiation and germinal center responses
Federica Alberghini, L. D’Artista, F. Mainoldi, F. Pisati, C. Carrisi, H. Koseki, M. Vidal, S. Casola;
Milano, Italy
048
P2.03.02 - The rheumatoid factor in idiotypic regulation of autoimmunity
Liubov Beduleva, I. Menshikov, E. Stolyarova, O. Lobanova;
Izhevsk, Russian Federation
049
P2.03.03 - Interleukin-10 suppresses CXCL8 gene transcription in LPS-stimulated monocytes via modulation of histone
deacetylases (HDACs) recruitment
Monica Castellucci, M. Rossato, N. Tamassia, S. Gasperini, F. Bazzoni;
Verona, Italy
050
P2.03.05 - Methylation patterns near and inside of the TSLP promoter in an african descendent population of Colombia
Luis Fang, A.J. Manrique, J.J. Builes, L. Hernandez, D.P. Aguirre, C. Muñoz, B. Martínez, J. Marrugo;
Cartagena, Colombia
051
P2.03.06 - Tumor Necrosis Factor Gene Polymorphisms in Tunisian Patients with Non -Small Cell Lung Cancer
Safa Kaabachi W.A.K. Fayçal Haj Sassi;
Tunis, Tunisia
052
P2.03.07 - Locus-specific biochemical epigenetics / chromatin biochemistry by insertional chromatin immnoprecipitation
(iChIP)
Toshitsugu Fujita, H. Fujii;
Suita, Osaka, Japan
053
P2.03.08 - The Research on IFN-γ,IL-4 Gene Methylation of Uighurs and Han Patients with Allergic Rhinitis in Xinjiang of China
Li Gao, X.f. Jiang, Q. Yang, Q.Q. Zhang, N.R. Mu, F.T. Liu, Z.Z. Lou;
Urumqi, China
054
P2.03.09 - Pronounced co-localization of immunoglobulin genes and their enhancers in transcription factories at the nuclear
periphery in plasma cells
S. Park, Y. Xiang, William T. Garrard;
Dallas, United States
055
P2.03.10 - Testing the resource-reallocation hypothesis: influence of maternal testosterone on immune system of
Japanese quail (Coturnix japonica) chicks
Zuzana Kanková, M. Okuliarová, M. Zeman;
Bratislava 4, Slovakia
120
Posters - August 24
056
P2.03.11 - Heterogeneity of Polycomb repressive complexes and long-noncoding RNA dictate the regulation network of
thymic T cell development
Masamoto Kanno, Y. Guo, K. Weng-Sheng, A. Nobukiyo, H. Inoue;
Hiroshima, Japan
057
P2.03.12 - Epigenetic regulation of T cell Ig mucin 3 expression in Th1 cells reveals a novel control of adaptive immunity
Chih-Chi Kuo, F. Chou, Y. Lin, H. Sytwu;
Taipei, Taiwan
058
P2.03.13 - DNA methylation changes in allergic patients correlate with symptom severity and reflect altered CD4+ T-cell
population structure
Antonio Lentini, C.E. Nestor, M. Gustafsson, H. Wang, H. Zhang, S. Bruhn, F. Barrenäs, M. Benson;
Linköping, Sweden
059
P2.03.14 - Targeted disruption of Calcium/NFAT signaling reveals a left-right determination disorder in the pharyngeal
arch artery
Yukihisa Miyachi;
Suita, Japan
060
P2.03.15 - Activation of Aryl hydrocarbon receptor (AhR) triggers epigenetic and microRNA modulation and consequent
differential regulation of Tregs and Th17 cells and amelioration of Experimental Autoimmune Encephalomyelitis (EAE)
Mitzi Nagarkatti, N.P. Singh, P. Nagarkatti;
Columbia, United States
061
P2.03.16 - Epigenetic regulation of cytokine production in sepsis and endotoxin tolerance
Claudia Reschke, D. Ibrahim, J. Hecht, H. Volk, G. Grütz;
Berlin, Germany
062
P2.03.17 - Impact of Wnt pathway activation in liver infiltrating T lymphocytes
Valeria Schinzari, C. Martire, M. Rossi, S. Brozzetti, V. Barnaba;
Rome, Italy
063
P2.03.18 - Evidence for in vivo DNA demethylation at Interferon-γ promoter site CpG island during human endotoxemia
Brendon P. Scicluna, M. Wevel, H. Belkasim, A. van der Meer, R. Lutter, T. van der Poll;
Amsterdam, Netherlands
064
P2.03.19 - Differential effects of histone-deacetylase inhibition during lipopolysaccharide-induced lung inflammation in
mice
Anne J. van der Meer, S.S. Zeerleder, C. van ‘t Veer, T. van der Poll;
Amsterdam, Netherlands
P2.04 MICRORNAS IN IMMUNE REGULATION
Session Time: Saturday, August 24, 13:20 - 15:00
065
P2.04.01 - miR-146, miR-21, and miR-31 expression in patients with active tuberculosis and subjects with latent tuberculosis
infection
E. Alijani, A. Poorfatholah, B. Sharifi Mood, A. Ahmad Zavaran Hosseini, Soheila Ajdary;
Tehran, Iran, Islamic Republic of
066
P2.04.02 - MicroRNA-mediated regulation of the pattern recognition receptor PTX3
Elisa Barbati, L. Mori, L. Zammataro, M. Rubino, A. Mantovani, C. Garlanda, M. Locati;
Rozzano, Milano, Italy
067
P2.04.03 - MiR-217 is an oncogene that enhances the germinal center reaction
Nahikari Bartolomé-Izquierdo, V. G de Yébenes, R. Nogales-Cadenas, P. Pérez-Durán, D. F Robbiani, M. Cañamero,
A. Pascual-Montano, A. R Ramiro;
Madrid, Spain
068
P2.04.04 - The effect of tumor cell derived exosomes on mesenchymal stem cells
A. Marton, M. Harmati, R. Katona, E. Gyukity-Sebestyén, I. Nagy, B. Horváth, C. Vizler, E. Duda, A. Borsodi, Krisztina Buzas;
Szeged, Hungary
069
P2.04.05 - MicroRNA modulations in plasmacytoid dendritic cell hyperactivity in systemic lupus erythematosus
Vera S. Chan, S. Yan, R.C.Y. Tam, N. Shen, C.S. Lau;
Pokfulam, Hong Kong
070
P2.04.06 - MicroRNA profiling in giant cell arteritis: diagnostic and prognostic potential
Stefania Croci, A. Zerbini, G. Pazzola, D. Nicoli, E. Farnetti, B. Casali, A. Cavazza, L. Boiardi, M. Parmeggiani, C. Salvarani;
Reggio Emilia, Italy
071
P2.04.07 - MicroRNAs dysregulation in human Chagas cardiomyopathy
Ludmila R.P. Ferreira, R.H. Santos, M.A. Baron, I. Navarro, P.C. Teixeira, N.A. Stolf, E. Bocchi, A. Fiorelli, J. Kalil, E. Cunha-Neto;
São Paulo, Brazil
072
P2.04.08 - Does HCMV employ miRNA mediated regulation to counter the antiviral mechanisms to maintain long latency
periods in Humans? An in silico study
Sunil B. Gosipatala, S. Saxena;
Lucknow, India
073
P2.04.09 - Anti-microRNA-378 Enhances Wound Healing Process by Up-regulating Vimentin and Integrin beta-3
Haoran Li, B. Yang;
Toronto, Canada
121
Posters - August 24
074
P2.04.10 - Global effect of IL-10-induced modulation of miRNAs expression on cytokine production by LPS-stimulated
human monocytes
Barbara Mariotti, M. Rossato, M. Castellucci, S. Gasperini, F. Bazzoni;
Verona, Italy
075
P2.04.11 - TNF influences microRNA expression during T cell activation
Viktor Molnár, B. Molnár-Érsek, E. Buzás, A. Falus, G. Nagy;
Budapest, Hungary
076
P2.04.12 - The miR-17-92 cluster is regulating naive T cell homeostasis as well as effector and memory differentiation
Gwennaelle C. Monnot, J.C. Dudda, B. Salaun, D. Utzschneider, D. Zehn, P. Romero;
Epalinges, Switzerland
077
P2.04.13 - Double stimuli by TLR7 and CD11c+ may change microRNA expression in murine plasmacytoids dendritic cells
Everton Padilha, T. Malardo, I.C. Fontoura, J.C.C. Lorenzi, B.P. Moreira, C.L. Silva, A.A.M. Coelho-Castelo;
Ribeirao Preto, Brazil
078
P2.04.14 - Anti-inflammatory function of miR-146a in human primary keratinocytes and atopic dermatitis
Ana Rebane, T. Runnel, A. Aab, B. Rückert, J. Maslovskaja, M. Zimmermann, M. Plaas, L. Kemeny, K. Kingo, C.A. Akdis;
Davos, Switzerland
079
P2.04.15 - Negative regulation of Toll-like receptor 4 signaling by the IL-10-dependent miR-146b
Tiziana A. Renzi, G. Curtale, M. Mirolo, M. Locati;
Rozzano, Italy
080
P2.04.16 - The role of microRNA 155 in innate immunity and arthritis
Victoria Saferding, E. Goncalves-Alves, A. Puchner, J. Smolen, K. Redlich, S. Blüml;
Vienna, Austria
081
P2.04.17 - Association of microRNA-146a target gene IRAK-1 polymorphism with enthesitis related arthritis category of
juvenile idiopathic arthritis
Sushma Singh, A. Aggarwal;
Lucknow, India
082
P2.04.18 - Regulated expression of microRNA-21 is involved in memory T-cell survival
Katarzyna Smigielska-Czepiel, A. van den Berg, P.G. Jellema, H. Maat, R.J. van der Lei, E. Brouwer, A.M.H. Boots, B.J. Kroesen;
Groningen, Netherlands
083
P2.04.19 - Aged T cell subsets are characterized by a distinct microRNA signature
Nato Teteloshvili, A. van den Berg, N. van der Geest, R.J. van der Lei, P. Jellema, E. Brouwer, A.M.H. Boots, B.J. Kroesen;
Groningen, Netherlands
084
P2.04.20 - MicroRNA-mediated regulation of TLR4 by immunosuppressive agent increases susceptibility to bacterial
infections
Emilie Tourneur, C. Chassin;
Paris cedex 18, France
085
P2.04.21 - Genome-wide identification of differentially expressed microRNAs in human plasma cell differentiation revealed
crucial microRNAs involved
Dong-Yan Tsai, S. Wu, C. Chung, A.C. Shih, K. Lin;
Taipei, Taiwan
086
P2.04.22 - Evaluation of expression pattern of miRNA146a in Pakistani rheumatoid Arthritis Patients
Sami Ullah, P. John, A. Bhatti;
Islamabad, Pakistan
087
P2.04.23 - Functional analysis for microRNA involving in arthritis
Tomo Yonezawa;
Chiba, Japan
088
P2.04.24 - Mir-34a promotes the development of Plasmacytoid dendritic cell
Jinping Zhang;
Suzhou, China
P3.07 B CELL DEVELOPMENT AND PLASMA CELL DIFFERENTIATION
Session Time: Saturday, August 24, 13:20 - 15:00
089
P3.07.01 - Differential expression of CD21 in different species
Marek Šinkora, J. Šinkorová;
Nový Hrádek, Czech Republic
090
P3.07.02 - Immunologic Alterations in Long-Term Divers
Hassan Abolhassani, A. Aghamohammadi, N. Rezaei, K. Ghorban, B. Dormanesh;
Tehran, Iran, Islamic Republic of
091
P3.07.03 - Class Switch Recombination Process in Common Variable Immunodeficiency
Asghar Aghamohammadi, H. Abolhassani, S. Moazzeni, A. Salek Farrokhi, P. Mohammadinejad, B. Mirminachi;
Tehran, Iran, Islamic Republic of
092
P3.07.04 - Class Switch Recombination Process in Common Variable Immunodeficiency
Asghar Aghamohammadi, H. Abolhassani, P. Mohammadinejad, A. Salek Farrokhi, S. Moazzeni, B. Mirminachi;
Tehran, Iran, Islamic Republic of
122
Posters - August 24
093
P3.07.05 - Allelically included B cells with two specificities are eliminated in the periphery
Leen Baudewijn, S. Gjoerup Saekmose, C. Dellgren, T. Barington;
Odense, Denmark
094
P3.07.06 - High-throughput mutant mouse characterisation is a powerful tool to identify novel immune phenotypes
Emma L. Cambridge, A.O. Speak, S. Clare, T. Sanger Mouse Genetics Project, R. Ramirez-Solis, D.J. Adams, G. Dougan, J.K. White;
Cambridge, United Kingdom
095
P3.07.07 - Functional analysis of synaptobrevin family members in secretion of antibodies by human plasma cells
L. Gómez-Jaramillo, L. Delgado-Pérez, F. Mora-López, R. Romero-García, G. Jiménez-Gómez, A. García-Poley, J.A. Brieva,
Antonio Campos-Caro;
Cádiz, Spain
096
P3.07.08 - B cell responses toward bacterial pathogens in human tonsils
Elisa Faenzi, F. Buricchi, E. Viciani, G. Santoro, F. Bagnoli, M. Barocchi, F. Castellino, G. Del Giudice, A. Manetti, O. Finco;
Siena, Italy
097
P3.07.09 - Ectonuclotidase activity in class switch recombination of murine B cells
Caterina E. Faliti, R. Rigoni, M. Proietti, E. Traggiai, F. Grassi;
Bellinzona, Switzerland
098
P3.07.10 - Primary Antibody Deficient Patients and ENT Complication
Alireza Ghajar, A. Aghamohammadi, A. Kouhi, M. Tavakol, M. Afarideh, H. Abolhassani;
Tehran, Iran, Islamic Republic of
099
P3.07.11 - IL-4 promotes B cell maturation in synergy with BAFF and confers resistance to cell death in negative selection
checkpoints
Alessandra Granato, B. Baptista, M. Bellio, A. Nóbrega, E. Hayashi;
Rio de Janeiro, Brazil
100
P3.07.12 - The hierarchical process of differentiation of long-lived antibody-secreting cells is dependent on integrated signals
derived from antigen and IL-17A
Lidiane Z. Grund, M. Lopes-Ferreira, C. Lima;
São Paulo, Brazil
101
P3.07.13 - Granzyme B-secreting B cells: suicidal or lethal?
Magdalena Hagn, D. Brasacchio, A. Brennan, J. Lopez, K. Thia, V. Sutton, J.A. Trapani;
Melbourne, Australia
102
P3.07.14 - Participation of arginine methyltransferase 1 in B cell development and differentiation
Kikumi Hata, N. Yanase, E. Takada, J. Mizuguchi;
Tokyo, Japan
103
P3.07.15 - Distinct processing of the pre-B cell receptor and the B cell receptor
J. Haimovich, S. Cohen, M. Toren, Nurit Hollander;
Tel Aviv, Israel
104
P3.07.16 - A functional BCR in human IgA and IgM plasma cells
D. Pinto, E. Montani, F. Sallusto, A. Lanzavecchia, David Jarrossay;
Bellinzona, Switzerland
105
P3.07.17 - The surrogate light chain selects Mu heavy chain based on its DH CDR-H3 sequence
Mohamed A. Khass, L. Watkins, Y. Zhuang, E. Capriotti, P.D. Burrows, H.W. Schroeder Jr.;
Birmingham, United States
106
P3.07.18 - Therapeutic effects of anti-APRIL blocking antibody on murine IgA nephropathy
Yang Gyun Kim, Y. Suzuki, H. Bertrand, H. Suzuki, M. Maikuma, M. Muto, S. Izui, S. Hirose, Y. Tomino;
Seoul, Korea, Republic of
107
P3.07.19 - SLAM-dependent and independent mechanism of IgE induction
Akihiko Kitoh, N. Kusuba, Y. Miyachi, S. Sakaguchi, Y. Yanagi, K. Kabashima;
Kyoto, Japan
108
P3.07.20 - Differences between IgG4+ and IgG1+ B cells provide insight into regulation of the IgG4 response
Laura C. Lighaam, E. Vermeulen, E.L. Culver, K.J. Meijlink, T.H. den Bleker, P. Ooijevaar-de Heer, E. Barnes, R.C. Aalberse, S.M. van Ham,
T. Rispens;
Amsterdam, Netherlands
109
P3.07.21 - The role of the histone demethylase Jmjd3 in B-cell lymphopoiesis
Rahmat Mahshid, T. Burgold, B. Khoramian, M. Caganova, F. Mainoldi, M. Reth, G. Natoli, G. Testa, S. Casola;
Milano, Italy
110
P3.07.22 - Protease-activated receptor (PAR)1 and PAR2 have opposing effects on B-lymphocyte function during different
stages of maturation
Kelly J. McKelvey, Y. Chan, C.J. Jackson, M. Xue;
St Leonards, Australia
111
P3.07.23 - Ataxia Telangiectasia Patients Presented by Class Switch Recombination Defect: Elevated Serum Levels of IgM
Babak Mirminachi, A. Aghamohammadi, H. Abolhassani, S. Ghosh, A. Borkhardt;
Tehran, Iran, Islamic Republic of
112
P3.07.24 - B cell development undergoes profound changes during pregnancy
Damián O. Muzzio, A.C. Zenclussen, F. Jensen;
Magdeburg, Germany
123
Posters - August 24
113
P3.07.25 - Influence of Wnt5a treatment on B-1 cells viability in vitro
Lika Osugui, M.C.T. Novo, M.F.L. Laurindo, A.F. Popi;
Sao Paulo, Brazil
114
P3.07.26 - Effects of Ouabain on B and T lymphocytes at mice
R.P.S. Barbosa, T.A.G. Vianna, J.M.C. Silva, K.M. Costa, F.B. Do Canto, V.R. Cabral, R. Fucs, Luciana S. Paiva;
Niterói/RJ, Brazil
115
P3.07.27 - Combination effect of LPS and MDP on antibody production by mouse B cells
S. Lee, Y. Yoo, J. Lee, P. Kim, G. Seo, Seok-Rae Park;
Daejeon, Korea, Republic of
116
P3.07.28 - Immunization of Common Variable Immunodeficiency (CVID) patients with Influenza induces increase in
switched memory B cells and plasmablasts
Maíra Pedreschi, A.K.B. Oliveira, M.T. Barros, A. Cohon, J. Kalil, C.M. Kokron;
Sao Paulo, Brazil
117
P3.07.29 - CD38 ligation promotes proliferation and ERK phosphorylation of bone marrow B-cell precursors in mice
Hector Romero-Ramirez, M. Morales-Guadarrama, R. Pelayo-Camacho, R. Lopez-Santiago, L. Santos-Argumedo;
Mexico, Mexico
118
P3.07.30 - Patients with X-linked Agammaglobulinemia Survival Rate : Mortality and Morbidity
A. Aghamohammadi, H. Abolhassani, F. Sefatgol, F. Shahriari, S. Sefatgol, Masoud Sefatgol;
Tehran, Iran, Islamic Republic of
119
P3.07.31 - Retinoic acid acts as a selective human IgA switch factor
Goo-Young Seo, S. Park, J. Kim, Y. Jang, J. Lee, H. Han, S. Kang, S. Kim, B. Jin, S. An, J. Choe, P. Kim;
Chuncheon, Korea, Republic of
120
P3.07.32 - Adaptor protein Swiprosin2/EFhd1 during early B cell development
Merle Stein, S. Dütting, S. Brachs, W. Schuh, A. Turqueti-Neves, D. Vöhringer, H. Jäck, D. Mielenz;
Erlangen, Germany
121
P3.07.33 - Serine/threonine phosphatase PP4 is required for pro-B cell development by promoting Ig VDJ recombination
Yu-wen Su, T. Tan;
Zhunan, Miaoli County, Taiwan
122
P3.07.34 - Y-Chromosome-linked B- and NK-cell deficiency in mice
Shu-lan Sun, A. Asao, T. Takahashi, T. So, M. Kondo, N. Ishii;
Sendai, Japan
123
P3.07.35 - ACKR3 (CXCR7) expression on late germinal center B cells
Marcus Thelen;
Bellinzona, Switzerland
124
P3.07.36 - Inhibition of germinal center formation and humoral immune responses by EB virus protein LMP1
Chiau-Yuang Tsai, T. Yasui, T. Minamitani, K. Morita, S. Sakakibara, H. Kikutani;
Osaka, Japan
125
P3.07.38 - B cell-intrinsic role of DOCK2 in T cell-dependent humoral immunity
Miho Ushijima, A. Nishikimi, Y. Fukui;
Fukuoka, Japan
126
P3.07.39 - Impact of genetic deficiencies in the TLR signaling pathways on human IgM+IgD+CD27+ B cells
Sandra Weller, S. Storck, L. Israel, S. Zhang, A. Puel, J.L. Casanova, C. Picard, J.C. Weill, C.A. Reynaud;
Paris, France
127
P3.07.40 - Follicular dendritic cells induce a new class of myeloid cells with unique B cell stimulating activities: specific
dependence on IL-34/CSF-1R signaling pathway
Fumihiro Yamane, K. Matsui, H. Tanimoto, E. Iwasaki, M. Asakura, H. Tokumitsu, Y. Nishikawa, N. Kanayama, M. Magari, H. Ohmori;
Okayama, Japan
128
P3.07.41 - The Non-Canonical function of UNG in AID induced Antibody Gene Diversification
Ashraf S. Yousif, N.A. Begum, T. Honjo;
Kyoto, Japan
P3.11 GAMMA-DELTA T CELLS
Session Time: Saturday, August 24, 13:20 - 15:00
129
P3.11.01 - CD2 expression determines two lineages of γδ T cells in swine
Marek Sinkora, K. Stepánová;
Nový Hrádek, Czech Republic
130
P3.11.02 - IL-17-producing gamma-delta T cells are crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice
Aoi Akitsu, H. Ishigame, S. Kakuta, S. Saijo, Y. Iwakura;
Chiba, Japan
131
P3.11.03 - Changes in Granzyme B expression in gamma delta T-cell in (HTLV-1)-associated myelopathy/tropical spastic
paraparesis patients
Raquel C. Albuquerque, O. Espindola, M.A. Lima, A.C.C. Leite, M.J. Andrada-Serpa, J. Echevarria-Lima;
Rio de Janeiro, Brazil
124
Posters - August 24
132
P3.11.04 - Involvement of γδ-T cells in the pathogenesis of autoimmune skin disorder: Pemphigus vulgaris
Vivek Anand, A. Raju, D. Das, S. Khandpur, V. Sharma, A. Sharma;
New Delhi, India
133
P3.11.05 - Exploiting NKG2D and lymphoid stress surveillance response in seronegative spondyloarthritis
Elisa Binda, A. Manzo, B. Vitolo, S. Bugatti, C. Montecucco;
Pavia, Italy
134
P3.11.06 - T Cell Dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
Ekua W. Brenu, S.L. Hardcastle, T.K. Huth, L. Cosgrave, D.R. Staines, S.M. Marshall-Gradisnik;
Gold Coast, Australia
135
P3.11.07 - In vivo IFN-alpha/ribavirin treatment modulates Vγ9Vδ2 T-cell function during chronic HCV infection
Eleonora Cimini, C. Bonnafous, H. Sicard, C. Vlassi, G. D’Offizi, M. Capobianchi, F. Martini, C. Agrati;
Rome, Italy
136
P3.11.08 - γδ T cells are required for the development of autoimmune anti myeloperoxidase glomerulonephritis
Poh-Yi Gan, J.D. Ooi, S.A. Summers, D. Odobasic, A.R. Kitching, S.R. Holdsworth;
Melbourne, Australia
137
P3.11.09 - Differentiation of human peripheral blood Vδ1 T cells expressing Natural Cytotoxicity Receptors: implications
for immunotherapies and the understanding of γδ T cell function
Kelly Hudspeth, D.V. Correia, M. Fogli, M. Gomes da Silva, J. Mikulak, A. Roberto, S. Della Bella, B. Silva-Santos, D. Mavilio;
Rozzano, Italy
138
P3.11.10 - Mycobacterium tuberculosis antigen specific changes of CDR3 length distribution of Vδ2 chain of human γδ T
lymphocytes
Baiqing Li, F. Ma, Y. Ding, Z. Wang, S. Guo, D. Xu, Y. Chen, J. Tang;
Bengbu, China
139
P3.11.11 - Respiratory syncytial virus infection influences FasL-mediated apoptosis of γδ T cells in a murine model of
allergen sensitization
Beixing Liu, S. Zeng, J. Liu, F. Qi;
Shenyang, China
140
P3.11.12 - Sensing cellular stress by γδ TCR
Romain Marlin, H. Kaminski, S. Netzer, V. Pitard, C. Harly, E. Scotet, J. Moreau, J. Dechanet-Merville;
Bordeaux, France
141
P3.11.14 - Understanding the crosstalk between γδ T cells and osteoclasts in patients with breast cancer
Swati P. Phalke, V. Parmar, R. Badwe, S. Chiplunkar;
Navi Mumbai, India
142
P3.11.15 - Toll-like receptor 2 ligand enhances effector function but not antigen presentation properties of gamma-delta T
cells
Desmond Poo, W. Wang, M. Teo, H. Toh;
Singapore, Singapore
143
P3.11.16 - Phenotypic characterisation of Human Vγ9Vδ2 T-cells
Paul L. Ryan, L.A. Bergmeier, D.J. Pennington;
London, United Kingdom
144
P3.11.17 - Human peripheral Vδ1+ γδ T cells can develop into αβ T cells
H. Ziegler, J. Haarer, M. Sterk, H. Rammensee, R. Handgretinger, Karin Schilbach;
Tübingen, Germany
145
P3.11.18 - The regulatory role of TCR Vδ1+ ΝΚT cells in systemic sclerosis patients with interstitial pneumonia
Segawa Seiji, D. Goto, M. Horikoshi, I. Matsumoto, T. Sumida;
Ibaraki, Japan
146
P3.11.19 - γδ T cells react against the murine cytomegalovirus
Sabrina Sell, M. Dietz, A. Schneider, M. Mach, T. Winkler;
Erlangen, Germany
147
P3.11.20 - TCR requirements for γδ T cell development
Nital Sumaria, D.J. Pang, J.F. Neves, K.V. Stoenchev, B. Silva-Santos, D.J. Pennington;
Whitechapel, United Kingdom
148
P3.11.21 - CD30L/CD30 signaling plays a critical role in maintenance and activation of IL-17A-producing γδ T cells in
mucosa-associated tissues in mice
Xun Sun, E.R. Podack, Y. Yoshikai, C. Lu;
Shenyang, China
149
P3.11.22 - Developing a protocol for large scale generation of antigen-pulsed gamma-delta T cells for cancer immunotherapy
Who-Whong Wang, K. Poo, M. Teo, H. Toh;
Singapore, Singapore
150
P3.11.23 - The role of phosphoantigen-expanded human γδ-T cells in the control of Epstein-Barr virus infection
Zheng Xiang, J. Zheng, Y. Liu, G. Qin, Y. Liu, J. Guan, K. Lam, Y. Lau, W. Tu;
Hong Kong, Hong Kong
151
P3.11.24 - Assessment of immune dysfunction in IgA-nephropathy patients
Mariya Yurkevich, H. Ivanchik, S. Bagatka, K. Komissarov, V. Pilotovich, M. Zafranskay;
Minsk, Belarus
125
Posters - August 24
P3.12 FOLLICULAR HELPER T CELLS
Session Time: Saturday, August 24, 13:20 - 15:00
152
P3.12.01 - MyD88 activated Monocyte-derived CD11b+ dendritic cells enhance Follicular Helper T cell differentiation
Svetoslav Chakarov, N. Fazilleau;
Toulouse, France
153
P3.12.02 - Regulation and B-cell help mediated by distinct subsets of IL-10-producing T-cells
Federica Facciotti, B. Haeringer, N. Gagliani, M. Paroni, P. Gruarin, L. Pignataro, R. Flavell, S. Abrignani, J. Geginat;
Milan, Italy
154
P3.12.03 - Role of Notch signal in the generation of follicular helper T cells (TFH) and memory T cell
Yohsuke Harada, K. Tokoyoda, K. Miyauchi, Y. Harada, A. Hanazawa, S. Ohno, Y. Yanagi, T. Takemori, M. Kubo;
Noda, Japan
155
P3.12.04 - Role of BCL6 and PD-1 in CD4 memory T cell development
Kristin Hollister, H. Wu, A. Dent;
Indianapolis, United States
156
P3.12.05 - B cell antigen presentation induces Tfh-differentiation from Th2 cells in vitro
Shu Horiuchi, H. Takebuchi, S. Konishi, K. Haniuda, T. Moutai, S. Takatsuka, D. Kitamura;
Noda-City, Chiba, Japan
157
P3.12.06 - ICOS is critical for maintenance of the T follicular helper phenotype
R.K. Franke, J.P. Weber, F. Fuhrmann, M. Al Baz, D. Vu Van, H.W. Mages, R.A. Kroczek, Andreas Hutloff;
Berlin, Germany
158
P3.12.07 - A positive feedback loop between splenic long-lived plasma cells and follicular helper T cells
Eunkyeong Jang, W. Chp, J. Youn;
Seoul, Korea, Republic of
159
P3.12.08 - Roles of follicular helper T (TFH) cells in antibody based protective immunity in influenza virus vaccination
Masato Kubo, K. Miyauchi, A. Sugimoto-Ishige, T. Kaji, Y. Takahashi, T. Takemori;
Yokohama, Japan
160
P3.12.09 - Costimulation through GITR increases follicular helper T cell formation and leads to control of a chronic viral
infection
M.F. Pascutti, C. Brandao, R.W. van Olffen, T. Poplonski, R.A.W. van Lier, Martijn A. Nolte;
Amsterdam, Netherlands
161
P3.12.10 - The implications of skin epidermal and dermal antigen-presenting cells in T follicular helper cell polarization
Charles Nuttens, L. Chonco, O. Bonduelle, S. Munier, B. Verrier, B. Combadiere;
Paris, France
162
P3.12.11 - Regulation of follicular helper T cells in Peyer’s patches by endoluminal ATP
Andrea Romagnani;
Bellinzona, Switzerland
163
P3.12.12 - TLR9 signaling acts on multiple elements of the germinal center to enhance antibody responses
Derek Rookhuizen, A.L. DeFranco;
San Francisco, United States
164
P3.12.13 - Antibody production and T forlicular helper response in mice immunized with modified HIV-1 envelope gp120
H. Yu, D. Tian, J. Wang, X. Wang, C. Guo, Y. Li, Min Zhuang, H. Ling;
Harbin, China
P3.14 B CELLS IN AUTOIMMUNITY AND REGULATORY B CELLS
Session Time: Saturday, August 24, 13:20 - 15:00
165
P3.14.01 - Immunoglobulins, Zn and NO in newly diagnosed children with type 1 diabetes
Mourad Aribi, I. Benghalem, K. Labadi, L. Hamouda, W. Meziane, M. Lammani;
Tlemcen, Algeria
166
P3.14.03 - FcγRIIb modulates IL-10 secretion by regulatory B cells: Implications for systemic sclerosis
A. Ferrier, O. Aravena, K. Pino-Lagos, J. Aguillón, L. Soto, Diego F. Catalan;
Santiago, Chile
167
P3.14.04 - Effects of fingolimod therapy on B cell biology in multiple sclerosis
Nele Claes, J. Fraussen, B. Van Wijmeersch, P. Stinissen, R. Hupperts, V. Somers;
Diepenbeek, Belgium
168
P3.14.05 - Altered lymphoid organogenesis yet normal development of T-cell mediated autoimmunity in mice with
skewed B-cell differentiation
Emanuela Colombo, P. Tentorio, S. Musio, K. Rajewsky, R. Pedotti, S. Casola, C. Farina;
Milan, Italy
169
P3.14.06 - Accumulation of circulating autoreactive naïve B cells reveal defects of early B cell tolerance checkpoints in
patients with Sjögren’s syndrome
Elisa Corsiero, N. Sutcliffe, H. Wardemann, C. Pitzalis, M. Bombardieri;
London, United Kingdom
170
P3.14.07 - Characterization of regulatory B cells in rodent model, able to transfer allograft tolerance via the TGFbeta pathway
Justine Durand, C. Usal, E. Merieau, M. Heslan, E. Chiffoleau;
Nantes, France
126
Posters - August 24
171
P3.14.08 - Protection from autoimmune nephritis in mice transgenic for BAFF, but lacking CD19
Kirsten A. Fairfax, F. MacKay-Fisson;
Melbourne, Australia
172
P3.14.09 - BAFF polymorphisms in Tunisian systemic lupus erythematosus patients
Yousr Gorgi, I. Sfar, T. Dhaouadi, N. Laamiri, S. Turki, L. Ben Hassine, T. Ben Abdallah;
Tunis, Tunisia
173
P3.14.10 - Direct PD-1-mediated suppression of autoreactive B cells by regulatory T cells
Janine Gotot, C. Gottschalk, P.A. Knolle, H. Yagita, C. Kurts, I. Ludwig-Portugall;
Bonn, Germany
174
P3.14.11 - Zap70+ b cells and plasmablasts as markers of disease activity and remission in systemic lupus erythematosus renal
involvement
Elisa Gremese, M. Nowik, L. Petricca, M. Gigante, L. Messutti, S. Canestri, C. Di Mario, G. Marino, B. Tolusso, G. Ferraccioli;
Rome, Italy
175
P3.14.12 - The precursor BCR suppresses T cell-dependent autoimmune responses
Ola Grimsholm, W. Ren, A.I. Bernardi, N. Höök, B. Bergmann, A. Stern, N. Cavallini, A. De Riva, I. Gjertsson, I. Mårtensson;
Gothenburg, Sweden
176
P3.14.13 - Functional properties of resident B cells in arterial walls of human atherosclerotic patients
Moustafa Hamze, C. Desmetz, C. Guzman, P. Roger, M. Berthe, N. Boulle, P. Branchereau, E. Picard, C. Tolza, P. Guglielmi;
Montpellier, France
177
P3.14.14 - Epigenetic manipulation of protective and pathogenic antibody responses with histone deacetylase inhibitors
Edwin D. Hawkins, M. Waibel, A. Frew, M. Hibbs, J. Shortt, R. Tothill, D. Tarlinton, R. Johnstone;
London, United Kingdom
178
P3.14.15 - Systemic immunoglobulin G to human dentin fractions decreases during orthodontic treatment
Eiko N. Itano, C.E.O. Lima, L.A. Nagashima, M.S. Kaminami, F.A. Nakanishi-Ito, E.T. Carlotto, E.O. Tanaka, T.T.M.P. Costa;
Londrina, PR, Brazil
179
P3.14.16 - Inhibition of formation of IgA1-containing immune complexes in IgA1 nephropathy
Alena Kasperova, H. Ueda, M. Stuchlova-Horynova, B. Julian, J. Novak, M. Raska;
Olomouc, Czech Republic
180
P3.14.17 - Can B cells induce the generation of regulatory T cells?
H.H. Mohammed Ali, Anna Kowalik, E. Kiernozek, E. Kozlowska, N. Drela;
Warsaw, Poland
181
P3.14.18 - IL-7 modulates B cells survival and activation by inducing BAFF and CD70 expression in T cells
Rebecka Lantto, S. Sammicheli, N. Ruffin, N. Vivar, F. Chiodi, B. Rethi;
Stockholm, Sweden
182
P3.14.19 - Bendamustine increases interleukin-10 secretion from B cells
Lu Le, A. Morita, K. Yoshimoto, H. Kameda, T. Takeuchi;
Tokyo, Japan
183
P3.14.20 - B-1 lymphocytes modify global gene expression by murine melanoma cells
P. Xander, R.R. Novaes e Brito, E.C. Pérez, J.M. Pozzibon, C.F. Souza, R. Pelegrino, V. Bernardo, M.G. Jasulionis, M. Mariano,
José D. Lopes;
São Paulo, Brazil
184
P3.14.21 - A novel flow-cytometry-based method to evaluate autoreactivity enables the study of B cell tolerance
checkpoints in mice
Emiliano Marasco, N. Manjarrez-Orduño, T. Hopkins, A. Athanassiou, J. Kiridly, P. Gregersen, B. Diamond;
Manhasset, United States
185
P3.14.22 - Strain-specific positive and negative regulatory roles for TLR9 in a mouse model of SLE
Robyn E. Mills, V. Lam, A. Weiss, M.L. Hermiston;
San Francisco, United States
186
P3.14.23 - Mast cells contribute to the expansion and differentiation of IL-10-producing B cells
Francesca Mion, F. D’Incà, L. Danelli, B. Frossi, C. Guarnotta, A. Burocchi, C. Tripodo, M.P. Colombo, G. Vitale, C.E. Pucillo;
Udine, Italy
187
P3.14.24 - Abnormal distribution of B-cells populations associated with impaired regulatory functions in the Chronic
Humoral Rejection
Alexandre Nouël, I. Segalen, A. Grall, J.O. Pers, Y. Le Meur, S. Hillion;
Brest, France
188
P3.14.25 - The autoantibodies to GM-CSF found in pulmonary alveolar proteinosis are generated through somatic mutations
Luca Piccoli, D. Corti, I. Campo, M. Luisetti, L. Varani, F. Sallusto, A. Lanzavecchia;
Bellinzona, Switzerland
189
P3.14.26 - CD38 and splenic B lymphocytes involvement in autoimmune disease using a murine model for systemic lupus
erythematosus
H. Romero Ramirez, M. Dominguez Pantoja, A. Dominguez Rívas, L. Santos Argumedo, Juan C. Rodríguez Alba;
Xalapa, Veracruz, Mexico
190
P3.14.27 - Generation of autoreactive and poly-reactive antibody producing cells during gamma-herpesvirus infection
Shuhei Sakakibara, T. Yasui, T. Minamitani, H. Jinzai, H. Kikutani;
Suita, Osaka, Japan
127
Posters - August 24
191
P3.14.28 - B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice
Patrizia Scapini, C. Lamagna, M.A. Cassatella, A.L. DeFranco, C.A. Lowell;
Verona, Italy
192
P3.14.29 - B-cell delivery of tolerogenic fusion proteins via anti-CD20 targeting
A. Zhang, David W. Scott;
Bethesda, United States
193
P3.14.30 - CD19 expression on B cells controls type 1 diabetes (T1D)
Robyn M. Slattery;
Melbourne, Australia
194
P3.14.31 - Limited somatic hypermutation in IgA of transglutaminase 2 specific as well as gluten specific plasma cells of
celiac disease intestinal lesions
Øyvind Steinsbø, C. Dunand, L. Mesin, M. Huang, M. Ferrer, K. Lundin, J. Jahnsen, P. Wilson, L. Sollid;
Oslo, Norway
195
P3.14.32 - Hydrodynamic DNA vaccination for induction of mouse monoclonal antibodies specifically reacting with
N-acetylgalactosaminide 2,6-sialyltransferase II (ST6GalNAc II)
M. Stuchlova Horynova, Alena Kasperova, Z. Smrzova, E. Weigl, H. Suzuki, J. Novak, M. Raska;
Olomouc, Czech Republic
196
P3.14.33 - B cell extrinsic MyD88 and FcR common gamma chain control contraction of the autoreactive extrafollicular B cell
response
Rebecca A. Sweet, J.L. Cullen, M.J. Shlomchik;
New Haven, United States
197
P3.14.34 - Renal Transplant Recipients lack circulating CD19+CD24hiCD38hi Interleukin-10 producing Regulatory
B-Lymphocytes
Bastian Tebbe, J. Wang, S. Dolff, A. Kribben, P. Hoyer, O. Witzke, A. Hoerning;
Essen, Germany
198
P3.14.35 - Endosomal TLR triggering hyperactivates B cells, induces plasma cells differentiation, class switch and
immunoglobulin production in Sjögren’s syndrome
S. Brauner, M. Kvarnström, L. Folkersen, S. Görgen, K. Brokstad, R. Jonsson, C. Trollmo, V. Malmström, G. Nordmark,
Marie Wahren-Herlenius;
Stockholm, Sweden
199
P3.14.36 - The role of B cells as antigen presenting cells in allergic inflammation
Tomasz Wypych;
Bellinzona, Switzerland
200
P3.14.37 - Anti-thrombin antibodies induced by dengue virus with both anti-thrombotic and pro-fibrinolytic activities
Trai Ming Yeh;
Tainan, Taiwan
P4.02 LIVER VIRAL INFECTIONS
Session Time: Saturday, August 24, 13:20 - 15:00
201
P4.02.01 - A deficient translocation of CD3ζ, ZAP-70 and Grb2 to lipid raft, as a hallmark of defective adaptive immune
response during chronic hepatitis B infection
Luisa Barboza, S. Salmen, G. Teran-Angel, D.L. Peterson, L. Berrueta;
Mérida, Venezuela, Bolivarian Republic of
202
P4.02.02 - HCV genotype 3 infected patients: Resistant and the relapsers
R.S.A. Khan, Qudsia Bashir, H. Bashir, I.A. Khawar, M.A. Rathore, A. Younis, S. Razak;
Islamabad, Pakistan
203
P4.02.03 - Possible routes of transmission among HCV infected Pakistani subjects
Qudsia Bashir, R.S.A. Khan, H. Bashir, I.A. Khawar, A. Younis, S. Razak;
Islamabad, Pakistan
204
P4.02.04 - Surface receptors and cytokines in CD4+ T cells upon HCV core transduction
Cecilia Matilde Fernández Ponce, M. Dominguez-Villar, J. Muñoz-Miranda, M. Duran, E. Aguado, F. Garcia-Cozar;
Cadiz, Spain
205
P4.02.05 - Cytokine profiles are modulated through the STAT family and define distinct clinical courses during hepatitis A
virus infection
F.P. Castro-Garcia, G. Escobedo-Melendez, K. Corral, M.A. Sandoval-Hernandez, M. Realpe, S. Roman, Y. Rosenstein, A. Panduro,
Nora A. Fierro;
Guadalajara, Mexico
206
P4.02.06 - Transcriptome profile of HCV-specific CD8 cells in early HCV infection
Paola Fisicaro, V. Barili, B. Montanini, A. Orlandini, E. Negri, F. Bianchi, G. Missale, S. Ottonello, C. Ferrari;
Parma, Italy
207
P4.02.07 - The role of Foxp3+ regulatory T cells in the inhibition of an adaptive immune response in a persistent HBV mouse
model
Yvonne A. Gäbel, L. Huang, N. Garbi, U. Protzer, P. Knolle;
Bonn, Germany
208
P4.02.08 - Monoclonal antibodies to various epitopes of HBs antigen inhibit HBV replication
Forough Golsaz Shirazi, H. Mohammadi, M. Amiri, K. Singethan, Y. Xia, A. Bayat, M. Bahadori, M. Jeddi –Tehrani, U. Protzer, F. Shokri;
Tehran, Iran, Islamic Republic of
128
Posters - August 24
209
P4.02.09 - Impact of cytokines and apoptosis genes polymorphisms on the outcome of hepatitis C virus infection
in Tunisian hemodialysed patients
Yousr Gorgi, L. Ksiaa Cheikh Rouhou, H. Aouadi, S. Jendoubi Ayed, I. Sfar, T. Ben Abdallah, K. Ayed;
Tunis, Tunisia
210
P4.02.10 - Immunogenetic factors of chronic hepatitis C and hepatocellular carcinoma development observed in atomicbomb survivors
Tomonori Hayashi, W. Ohishi, K. Imai, K. Yoshida, I. Hayashi, Y. Hu, J. Kajimura, S. Kyoizumi, Y. Kusunoki, K. Nakachi;
Hiroshima, Japan
211
P4.02.11 - Prevalence of GBV-C/HGV and HCV among HIV infected populations in South Iran
Mohammad Jafari, M. Mohsenzadeh, M.r. Fathi, A. Pirouzi;
Shiraz, Iran, Islamic Republic of
212
P4.02.12 - Serum IP-10 profiles over time in treatment-experienced hepatitis C patients treated with a HCV NS3/4A protease
inhibitor in combination with peginterferon and ribavirin
Susanne Johansson, L. Vijgen, W. Talloen, M. Beumont-Mauviel, M. Peeters, O. Lenz, J. Aerssens;
Beerse, Belgium
213
P4.02.13 - Infectious diseases: Viral infections prevalence among gastroenterology patients
Iftikhar A. Khawar, R.S.A. Khan, H. Bashir, Q. Bashir, A. Younis, S. Razak;
Kampala, Uganda
214
P4.02.14 - TLR-2 promotes both mouse hepatitis virus (MHV) replication and inflammatory responses in hepatocytes
leading to fulminant hepatitis
C. Bleau, M. Burnette, A. Jacques, M. Samson, C. Piquet-Pellorce, Lucie Lamontagne;
Montréal, Canada
215
P4.02.15 - The altered phenotype of CD4+CXCR5+ T cells and B cells is associated with the chronic hepatitis B virus infection
Yu Lei, T. Hu, X. Song, M. Chen, Z. Zhou, D. Zhang, H. Hu, P. Hu, H. Ren;
Chongqing, China
216
P4.02.16 - Interleukin-6, tumor necrosis factor- and interleukin -10 polymorphisms are associated with the cytokines
serum levels of hepatitis C virus infection in Brazilian Population
A.M. Tarragô, A.G. da Costa, J.P.D. Pimentel, S. Gomes, P. Lalwani, A.S. de Araújo, R.A. Marie, A.C. Vallinoto, A. Sadahiro, Adriana
Malheiro;
Manaus, Brazil
217
P4.02.17 - HHV-8 and hepatitis infections in pemphigus
Kaouthar Mejri, M. Kallel Sellami, I. Zarraa, L. Laadhar, W. Tombari, M. Mokni, I. Mokhtar, B. Fazaa, M. Zitouni, S. Makni;
Tunis, Tunisia
218
P4.02.18 - Epitope mapping and identification of mutated hepatitis B surface antigens by mouse monoclonal antibodies
Hamed Mohammadi, F. Golsaz-Shirazi, A. Roohi, M. Amiri, A. Bayat, J. Mahmoudian, M. Jeddi-Tehrani, F. Shokri;
Tehran, Iran, Islamic Republic of
219
P4.02.19 - The diverse roles of necroptosis and inflammatory signaling during chronic overwhelming infections
Simon P. Preston, G. Ebert, J.P. Cooney, M. Pellegrini;
Melbourne, Australia
220
P4.02.21 - Polarized effector function of NK cells in chronic hepatitis C is partially dependent on the IL28B genotype
Magdalena Rogalska-Taranta, A.A. Markova, S. Westhaus, S. Lunemann, A. Taranta, V. Schlaphoff, M.P. Manns, M. Cornberg,
S. Ciesek, H. Wedemeyer;
Hannover, Germany
221
P4.02.22 - Programmed hepatocytes cell death associated with FLIP dowregulation and Bid activation in response to
extracellular PreS1/2
Siham Salmen, M.D. Rojas, D.L. Peterson, L. Berrueta;
Merida, Venezuela, Bolivarian Republic of
222
P4.02.23 - Detection of hepatitis B virus variants in Tunisian patients
Latifa Satouri;
Tunis, Tunisia
223
P4.02.24 - The Cytotoxic T Lymphocyte Response to HLA-Cw08-restricted Envelope Epitope in Resolved Hepatitis B Infection
Pimpayao Sodsai, A.T. Tan, N. Kirankarn, A. Bertoletti;
Bangkok, Thailand
224
P4.02.25 - Association of MICA variants and hepatitis B virus induced hepatocellular carcinoma
Hoang V. Tong, N.L. Toan, L.H. Song, T. Bock, P.G. Kremsner, V. TP;
Tuebingen, Germany
225
P4.02.26 - Enhancement of anti-HCV T cell immunity by immunization with an adenoviral vector encoding a TLR4-targeted
NS3 protein
Lorea Villanueva, F. Aranda, A. Pereboev, L. Silva, D. Llopiz, A. Zabaleta, L. Arribillaga, J. Prieto, J.J. Lasarte, P. Sarobe;
Pamplona, Spain
226
P4.02.27 - Fulminant hepatitis caused by virus infection was controlled by BTLA signaling
Yuzhang Wu, Y. Chen, C. Yang, S. Wu;
Chongqing, China
227
P4.02.28 - P300, but not PCAF, collaborates with IRF-1 in stimulating TRIM22 expression, that is independent on its histone
acetyltransferase activity
Sidong Xiong, B. Gao, W. Xu;
Suzhou, Jiangsu Province, China
129
Posters - August 24
228
P4.02.29 - Intrahepatic CXCR3-associated chemokines and circulating autoantibody profiles in patients chronically infected
with hepatitis C virus
Andy Q. Yu, M. Ghabril, Z. Meng, S. Hu, T. Amet, D. Byrd, J. Lan, N. Chalasani;
Indianapolis, United States
P4.04 IMMUNITY TO BACTERIAL INFECTION (EXCLUDING MYCOBACTERIA)
Session Time: Saturday, August 24, 13:20 - 15:00
229
P4.04.01 - Mice oral immunization against Vibrio cholera: Zot and Ace recombinant proteins used as a subunit vaccine
Shaghayegh Anvari, S. Najar Peerayeh, A. Memarian, M. Behmanesh, S.D. Siadat;
Gorgan, Iran, Islamic Republic of
230
P4.04.02 - Antibodies against outer membrane proteins of Moraxella catarrhalis and nontypeable Haemophilus influenzae
cross-react with various pathogens of human respiratory tract
Daria Augustyniak, J. Bonarowska, P. Mackiewicz, Z. Drulis-Kawa;
Wroclaw, Poland
231
P4.04.03 - Functionality of cross-reactive antibodies against Moraxella catarrhalis
Daria Augustyniak, M. Piekut, G. Majkowska-Skrobek;
Wroclaw, Poland
232
P4.04.04 - Secondary bacterial pneumonia following flu infection: Pathogenesis and protective immunity
Mariana E. Bernui, H. Shen;
Phladelphia, United States
233
P4.04.05 - Induction of Mast Cell Extracellular Traps by intracellular bacteria
Marcia Campillo-Navarro, J. Serafín-López, I. Estrada-García, M. González-jimenez, A. Cerbulo-Vazquez, K. Leyva-Paredes,
B. García-Pérez, L. Donis-Maturano, S. Estrada-Parra, R. Chacon-Salinas;
Mexico city, Mexico
234
P4.04.06 - Plasmin Cleaves Human complement C3b and C5 Proteins in the Presence of Leptospira interrogans Proteins:
A New Role of LigA and LigB for complement Immune Evasion
Mónica M. Castiblanco-Valencia, T.R. Fraga, L.B. Silva, D. Monaris, P.A.E. Abreu, A.S. Barbosa, L. Isaac;
São Paulo, Brazil
235
P4.04.07 - A murine air pouch model to study group A streptococcal pathogenesis and protective immunity
Nico Chiappini, A. Seubert, P. Fontani, J.L. Telford, D. Serruto, G. Grandi, I.M. Y Ros, R. Janulczyk;
Siena, Italy
236
P4.04.08 - Investigation of innate immunity genes on the japanese oak silkworm, Anthereae yamamai
Kwangho Choi, S. Kim, S. Kim, S. Kang, T. Goo;
Suwon, Korea, Republic of
237
P4.04.09 - An inhibitor of sirtuin 1 and sirtuin 2, cambinol, impairs MAPK signaling, inhibits inflammatory and innate immune
responses and protects from septic shock
Eleonora Ciarlo, J. Lugrin, A. Santos, G. Grandmaison, I. Dos Santos Pinheiro, D. Le Roy, T. Roger;
Lausanne, Switzerland
238
P4.04.10 - Study of the impact of Sirtuin 2 knockout on innate immune responses and sepsis
Eleonora Ciarlo, J. Lugrin, I. Dos Santos Pinheiro, D. Le Roy, N. Moulan, H. Yamamoto, H. Acha-Orbea, T. Calandra, J. Auwerx,
T. Roger;
Lausanne, Switzerland
239
P4.04.11 - Immune-response in lesional skin of secondary syphilis
Marco Cusini, V. Merlo, L. Corti, R. Gianotti, L. Venegoni, E. Berti;
Milan, Italy
240
P4.04.12 - The role of neutrophil extracellular traps (NETs) in the host defense against Gram-negative sepsis (melioidosis)
Hanna K. de Jong, G.C.K.W. Koh, T.A.F. Weehuizen, A. Achouiti, F. Stephan, N.P.J. Day, S.J. Peacock, S. Zeerleder, T. van der Poll,
W.J. Wiersinga;
Amsterdam, Netherlands
241
P4.04.13 - Protease Activated Receptor 4 contributes to host defense in Streptococcus pneumoniae induced pneumonia
Sacha F. de Stoppelaar, C. van ‘t Veer, F.E. van den Boogaard, R. Nieuwland, A.J. Hoogendijk, O.J. de Boer, J.J.T.H. Roelofs,
T. van der Poll;
Amsterdam, Netherlands
242
P4.04.14 - Streptococcus pneumoniae serine protease HtrA, but not SFP or PrtA, is a major virulence factor in pneumonia
Sacha F. de Stoppelaar, H. Bootsma, A. Zomer, J.J.T.H. Roelofs, P.W. Hermans, C. van ‘t Veer, T. van der Poll;
Amsterdam, Netherlands
243
P4.04.15 - Th9 and Th22 cytokines profiles expressed by TCD4+ lymphocytes activated with different Aggregatibacter
actinomycetemcomitans-serotypes
Jaime Díaz-Zúñiga, S. Melgar-Rodríguez, C. Alvarez, R. Vernal;
Santiago, Chile
244
P4.04.16 - Undernutrition and birth season influence the antibody response to B. pertussis in children of Northern Senegal
Lobna Gaayeb;
Saint-Louis, Senegal
245
P4.04.17 - Immuno-microbiological aspects of chronic apical periodontitis
L.A. Mozgovaya, I.I. Zadorina, L.P. Bykova, Anatoliy P. Godovalov;
Perm, Russian Federation
130
Posters - August 24
246
P4.04.18 - Thrombospondin 1 expression in THP-1 cells stimulated with periodontopathic bacteria
Misa Gokyu, H. Kobayashi, H. Nanbara, Y. Changchang, Y. Izumi;
Tokyo, Japan
247
P4.04.19 - Development of an in vitro infection model for the evaluation of viable, macrophage-engulfed Pseudomonas
aeruginosa
Laura K. Green, A.C. La Flamme, D.F. Ackerley;
Wellington, New Zealand
248
P4.04.20 - Protective immunity of intranasally infected mice with Brucella Melitensis
Delphine Hanot Mambres, E. Muraille, J. Letesson;
Namur, Belgium
249
P4.04.21 - DAP12 impairs host defense in pneumococcal pneumonia
Tijmen J. Hommes, A.A. Anas, M.C. Dessing, C. van ‘t Veer, A. de Vos, T. van der Poll;
Amsterdam, Netherlands
250
P4.04.22 - TREM-1 improves host defense in pneumococcal pneumonia
Tijmen J. Hommes, M.C. Dessing, M. Colonna, C. van ‘t Veer, A. de Vos, T. van der Poll;
Amsterdam, Netherlands
251
P4.04.23 - Immune Evasion by Staphylococcal Superantigen-Like Protein 10
Weilin Hou, D. Patel, R.J. Langley, J.D. Fraser;
Auckland, New Zealand
252
P4.04.24 - State of cellular immunity in children with Recurrent Respiratory Tract Infections before and after vaccination
Pneumo23 and Influvac
Rasima R. Isayeva;
Baku, Azerbaijan
253
P4.04.25 - Long-term protective immunity of multi-antigen outer-membrane protein vaccine against Orientia tsutsugamushi
WoonHee Jeung, S. Park, H. Chu, I. Cheon, B. Shim, S. Han, C. Yun;
Seoul, Korea, Republic of
254
P4.04.26 - Evaluation of antimicrobial effects of Silver, Zinc and Copper nanoparticles on different Bacillus species spores
and vegetative cells
Roya Khosravi Eghbal, A. Khanafari, A. Akhavan Sepahy;
Tehran, Iran, Islamic Republic of
255
P4.04.27 - Differential immune cell responses of infected lung tissues in mice strains with different susceptibility to
Legionella pneumophila
Seung Min Kim, Y. Yoon, J. Sohn, M. Kim;
Seoul, Korea, Republic of
256
P4.04.28 - Poly(I:C) sensitization induces a cytokine imprinting mechanism in dendritic cells and aggravates septic peritonitis
Magdalena Kocur, J. Bauer, S. Kropp, S. Scheu;
Duesseldorf, Germany
257
P4.04.29 - Cathepsin X inhibitor decrease the production of cytokines and monocyte microparticles on
THP-1 macrophage-like cells stimulated with Helicobacter pylori
Andreja N. Kopitar, S. Jeverica, J. Kos, A. Ihan;
Ljubljana, Slovenia
258
P4.04.30 - Mechanisms underlying bacteria-infected macrophage cell death-mediated IFN-γ production by innate
lymphocytes
Koichi Kubota;
Sagamihara, Japan
259
P4.04.31 - Mechanisms of NK cell-macrophage Bacillus anthracis crosstalk: a balance between stimulation by spores and
differential disruption by toxins
Mathieu Le Gars, M. Klezovich-Bénard, J. Corre, H. Jusforgues-Salkani, D. Fiole, N. Burjek, J. Tournier, P. Goossens;
Paris, France
260
P4.04.32 - Autophagy and cell death pathways in Shigella-infected MoDCs: a difficult choice
Luigi Lembo Fazio, A. Hermansson, V. Ciancarella, E. Mileti, G. Fimia, M. Rescigno, M. Bernardini;
Rome, Italy
261
P4.04.33 - Group B Streptococcus and Streptococcus suis differently modulate bacterial interactions with dendritic cells and
natural killer cells
Paul Lemire, D. Roy, M. Segura;
St-Hyacinthe, Canada
262
P4.04.34 - Immunoregulative mechanism of the Leydig cell in the infection by expression of IL-1, IL-6, TGF-β, Fas and FasL
mRNA
Weiyi Li, Y. XI, G. Chen;
Shanghai, China
263
P4.04.35 - Differential inflammasome activation in human macrophages between Salmonella Typhimurium and
Salmonella Typhi
Hsin-Hung Lin, C. Chiu;
Taoyuan,, Taiwan
264
P4.04.36 - Oral infection with Brucella abortus 2308 induces systemic activation of B cells, but a downregulation of CD86 in
intestine B cells
K.E. Pineda-Benito, O. Rodríguez-Cortés, A. Gutiérrez-Hoya, D. Sandoval-Borrego, Rubén López-Santiago;
Mexico DF, Mexico
131
Posters - August 24
265
P4.04.37 - The mechanism behind insufficient Streptococcus pyogenes clearance by autophagy in endothelial cells
compared to epithelial cells
ShiouLing Lu, Y. Lin, T. Yoshimori;
NCKU, Tainan, Taiwan; Osaka University, Osaka, Japan
266
P4.04.38 - Detailed antibody-profile of Helicobacter pylori infected individuals revealed by peptide array screening
Samuel B. Lundin, K. Thorell, I. Nookaew, T. Perkins;
Gothenburg, Sweden
267
P4.04.39 - Mechanism of interleukin (IL)-17A-mediated enhancement of protective immunity against Listeria
monocytogenes infection
Goro Matsuzaki, Y. Okita, T. Shiono, S. Hamada, M. Umemura;
Nishihara, Okinawa, Japan
268
P4.04.40 - PKF, a secreted serine protease, allows Acinetobacter baumannii to evade innate immune responses
Larry S. McDaniel, L.B. King;
Jackson, United States
269
P4.04.41 - Effect of the stimulation with different serotypes Aggregatibacter actinomycetemcomitans in the activity of
the lymphocytes TCD4+
Samanta Melgar-Rodríguez, J. Díaz-Zúñiga, C. Álvarez, R. Vernal;
Santiago, Chile
270
P4.04.42 - A neutrophil elastase inhibitor improves LPS-induced acute lung injury in burn-injured mice
Hiromi Miyazaki, S. Ono, M. Kinoshita, R. Takahata, A. Kimura, D. Saitoh;
Tokorozawa, Japan
271
P4.04.43 - Citrullination and proteolytic processing of chemokines by Porphyromonas gingivalis
Eva A.V. Moelants, G. Loozen, A. Mortier, J. Van Damme, W. Teughels, P. Proost;
Leuven, Belgium
272
P4.04.44 - Intracellular crosstalk in Wnt5a expression by LPS
Hiromi Nanbara, Y. Yoshida, N. Wara-aswapati, T. Nagasawa, H. Kobayashi, Y. Izumi;
Tokyo, Japan
273
P4.04.45 - The transformation of subpopulations CD64+CD16-CD32+CD11b+, CD64+CD16+CD32+CD11b+, CD64-CD16+
CD32+CD11b+ of monocytes in premature newborn with congenital pneumonia
Irina V. Nesterova, G.A. Chudilova, L.V. Lomtatidze, O. Sapun, R.I. Sepiashvili;
Moscow, Krasnodar, Russian Federation
274
P4.04.46 - Gestational hypothyroidism and its effects on the offspring immune response against infection: Evaluation in a
murine model of pneumococcal pneumonia
Pamela A. Nieto, F.J. Salazar, H.F. Peñaloza, B.M. Schultz, A.M. Kalergis, C.A. Riedel, S.M. Bueno;
Santiago, Chile
275
P4.04.47 - Specific pulse-width mild electrical stimulation induces p53 activation via p38 MAPK and ameliorates
LPS-induced inflammatory cytokine response
R. Fukuda, Kohei Omachi, M.A. Suico, K. Koyama, Y. Kai, S. Matsuyama, K. Mitsutake, S. Morino-Koga, T. Shuto, H. Kai;
Kumamoto-si, Japan
276
P4.04.48 - Legionella pneumophila thymidine auxotroph mutant promote a protective immunity dependent on the
bacterial Dot/Icm secretion system and Myd88 signaling pathway against Legionella pneumophila flaAMarcelo Pereira, D.S. Zamboni;
Ribeirão Preto, Brazil
277
P4.04.49 - A critical role for Interferon-gamma but not IL-17 in staphylococcal superantigen-mediated toxic shock syndrome
A. Scheid, A. Tilahun, V. Chowdhary, Govindarajan Rajagopalan;
Rochester, United States
278
P4.04.50 - Evaluation of the immune response against Brucella abortus in splenectomized mice
Alice B. Rezende, N.N. Neto, O.H.M. Assis, C.S. Miranda, M. Mota, G.C. Macedo, H.C. Teixeira;
Juiz de Fora, Brazil
279
P4.04.51 - Physiological significance of the sodium/proline transporter putP of Helicobacter pylori
Araceli Rivera-Ordaz, S. Imrich, H. Jung;
Martinsried, Germany
280
P4.04.52 - Protection from severe bacterial infection by injections of cytokine-gene transfected cells
Tatsuo Saito-Taki, T. Onogawa, H. Kitasato;
Sagamihara, Japan
281
P4.04.53 - The scavenger receptor CD36 downmodulates the early inflammatory response while enhancing bacterial
phagocytosis during pneumococcal pneumonia
Simona Saluzzo, O. Sharif, U. Matt, K. Lakovitz, S. Knapp;
Vienna, Austria
282
P4.04.54 - Identification of functional polymorphisms of the macrophage migration inhibitory factor (MIF) gene associated
with morbidity and mortality in pneumococcal meningitis and sepsis
Athina Savva, M.C. Brouwer, T. Roger, P. Bochud, D. Le Roy, A. van der Ende, D. van de Beek, T. Calandra;
Lausanne, Switzerland
283
P4.04.55 - Phagocytic activity in antibiotic and bacteriophage therapy of peritonitis caused by Escherichia coli
Ganna Siritsa, O. Kosilova, H. Khidwrbagi;
Kharkov, Ukraine
132
Posters - August 24
284
P4.04.56 - Infection with invasive bacterial pathogens triggers distinct Nod-dependent autophagy and cytokine responses
Matthew Sorbara, S. Girardin, D. Philpott;
Toronto, Canada
285
P4.04.57 - Selective criteria and important features of protective monoclonal antibodies to tetanus toxin
Ivana D. Stojicevic, E.M. Marinkovic, I.P. Zivkovic, V.Z. Petrusic, L.A. Dimitrijevic, M.M. Stojanovic;
Belgrade, Serbia
286
P4.04.58 - Th1-Th17 cells mediate pelvic pain induced by uropathogenic Escherichia coli
Praveen Thumbikat, L. Wong, M. Quick, J.D. Done, A.J. Schaeffer;
Chicago, United States
287
P4.04.59 - Anti-alpha toxin mAb promotes both innate and adaptive immune response in a CA-MRSA USA300 mouse
dermonecrosis model
Christine Tkaczyk, X.P. Yang, M. Hamilton, V. Datta, J. Suzich, C.K. Stover, B.R. Sellman;
Gaithersburg, United States
288
P4.04.60 - A novel polarized ex-vivo organ culture model to study gut inflammation and response to probiotics
Aikaterini Tsilingiri, M. Rescigno;
Milano, Italy
289
P4.04.61 - Study of the development of actinomycetoma during Nocardia brasiliensis infection in mice with partial genetic
blockade of eNOS
Anna Velia Vázquez-Marmolejo, M. Salinas-Carmona, L. Pérez-Rivera, A. Atilano-Díaz, D. Domínguez-Armendariz,
H. Garza-Esquivel, J. López-Ulloa, L. Fernández-Carrizales;
Monterrey, Nuevo Leon, Mexico
290
P4.04.62 - Neutrophilic granulocyte subtype recruitment in human peritonitis
Sibylle von Vietinghoff, L. Wang, S. Ge, M. Hiss, H. Haller;
Hannover, Germany
291
P4.04.64 - Protective immunity against invasive Streptococcus pneumoniae infections by tissue-specific memory Th17 cells
Yan Wang, B. Jiang, J.N. Weiser, H. Shen;
Philadelphia, United States
292
P4.04.65 - Differential inflammasome activation by Salmonella strains expressing mutant forms of the NLRC4 ligands FliC and PrgJ
John A. Wright, S. Man, G. Frazer, C.E. Bryant;
Cambridge, United Kingdom
293
P4.04.66 - The effect of dietary oils on citrobacter rodentium induced colitis
Xiujuan Wu, A. Hekmatdoost, V. Morampudi, S.M. Innis, K. Jacosbon;
Vancouver, Canada
294
P4.04.67 - A mouse model of shigellosis by intraperitoneal infection
Jin-Young Yang, S. Lee, M. Kweon;
Seoul, Korea, Republic of
295
P4.04.68 - Production and characterization of neutralizing monoclonal antibodies directed against tetanus toxin fragment C
Mehdi Yousefi, F. Tahmasebi, V. Younesi, A. Razavi, J. Khoshnoodi, A. Bayat, E. Abbasi, H. Rabbani, M. Jeddi-Tehrani, F. Shokri;
Tehran, Iran, Islamic Republic of
296
P4.04.69 - Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production via
PI3K/Akt/GSK3β pathway
Yuejuan Zheng, Y. Yang, Y. Li, L. Xu, Y. Wang, H. Song, G. Ji, Y. Yu;
Shanghai, China
297
P4.04.70 - Anaphylatoxin C5a promotes kidney infection caused by uropathogenic E. coli
K. Li, N. Choudhry, Q. Peng, N. Wang, B. Lu, S. Sacks, Wuding Zhou;
London, United Kingdom
P4.05 IMMUNITY TO MYCOBACTERIAL INFECTION
Session Time: Saturday, August 24, 13:20 - 15:00
298
P4.05.02 - Regulation of granuloma formation in response to infection with Mycobacterium tuberculosis
Neha Agrawal, U. Ullah, K.V.S. Rao;
New Delhi, India
299
P4.05.03 - Role of Oxidative stress associated anemic prevalence among Leprosy Patients
Abdul Azeez M. Ahamed, A.M. Pradeep, N. Vetrivel;
Madurai, India
300
P4.05.04 - Immunotherapeutic effects of recombinant adenovirus encoding granulocyte-macrophage stimulating-colony
factor in experimental pulmonary tuberculosis
Francisco-Cruz Alejandro, M. Dulce, X. Zhou, H. Rogelio;
Mexico, Mexico
301
P4.05.05 - Clinical isolates of Mycobacterium tuberculosis in Argentina differentially induces respiratory burst via TLR2 and
dectin-1 in neutrophils as possible mechanism of immune escape
M. Romero, J.I. Basile, B. Lopez, V. Ritacco, L. Barrera, M.C. Sasiain, Mercedes Aleman;
Buenos Aires, Argentina
133
Posters - August 24
302
P4.05.06 - P2X7 receptor activation by ATP released from necrotic cells is crucial to severity of tuberculosis caused by
hypervirulent mycobacteria
Eduardo P. Amaral, M.R.M. Andrade, S.C.M. Ribeiro, V.R. Lanes, F.M. Almeida, E.M. Salles, K.R. Bortoluci, J.M.M. Alvarez, E. Lasunskaia,
M.R. D’Império-Lima;
Sao Paulo, Brazil
303
P4.05.07 - Mixed DC /macrophage lineage phenotypes in activated lepromatous lesions during reverse reaction
Priscila R. Andrade, T.P. Amadeu, A. Miranda, R.O. Pinheiro, J. Nery, E.N. Sarno;
Rio de Janeiro, Brazil
304
P4.05.08 - In vitro TLR2 and CD14 gene silencing effect in the control of Mycobacterium tuberculosis infection
Alma Y. Arce-Mendoza, F. Hernandez-Cabrera, A.G. Rosas-Taraco;
Monterrey, Mexico
305
P4.05.09 - Pilot study: cytokine pattern in children under eight years with pulmonary tuberculosis
Mónica Adriana Asturizaga Mallea, D. Correa, A. Escobar-Gutiérrez, Y. Flores-García, L. Pérez-Fernández, F. Cuevas-Schacht;
Mexico, Mexico
306
P4.05.10 - Dynamics of the immune response to DosR and Rpf antigens of Mycobacterium tuberculosis in house hold
contacts of tuberculosis patients
L. Arroyo, B. Ortiz, M. Rojas, L.F. García, T. Ottenhoff, Luis F. Barrera;
Medellin, Colombia
307
P4.05.11 - Functional modulation by Cortisol and/or Dehydroepiandrosterone on THP1-derived macrophages infected
with Mycobacterium tuberculosis
B. Bongiovanni, D. Mata Espinosa, R. Marquez Velasco, O.A. Bottasso, R. Hernandez Pando, María L. Bay;
Rosario, Argentina
308
P4.05.12 - Assessment the activity of blood phagocytes at tuberculosis of lungs
Olga V. Berdugina, S.N. Skornyakov, I.D. Medvinsky, A.V. Ershova, K.A. Berdugin;
Ekaterinburg, Russian Federation
309
P4.05.13 - Immunological assessment of inflammatory reaction at patients with different forms of tuberculosis of lungs
Olga V. Berdugina, S.N. Skornyakov, I.D. Medvinsky, A.V. Ershova, K.A. Berdugin;
Ekaterinburg, Russian Federation
310
P4.05.14 - Mycobacterium tuberculosis antigen-specific immune responses among tuberculosis lymphadenitis patients
Kidist Bobosha, L. Wassie, M. Habtamu, M. Zewdie, J. Hussien, L. Yamuah, A. Aseffa;
Addis Ababa, Ethiopia
311
P4.05.15 - Integrin alpha2 beta1 modulates MMP-1 expression in Tuberculosis
Sara Brilha, J.C. Porter, H. Zecchini, J.S. Friedland;
London, United Kingdom
312
P4.05.16 - Degradation of cholesterol is essential for the pathogenicity of Mycobacterium tuberculosis
Marta Brzezinska, I. Szulc, M. Klink, A. Brzostek, M. Kielbik, Z. Sulowska, J. Dziadek;
Lodz, Poland
313
P4.05.17 - Granzyme A is an additional marker for tuberculosis (TB) to discriminate between patients with active disease
and subjects with latent infection
Nadia Caccamo, V. Orlando, M. La Manna, D. Di Liberto, S. Cutrera, F. Dieli, V. Vanini, E. Petruccioli, D. Goletti;
Palermo, Italy
314
P4.05.18 - Mycobacterium tuberculosis Beijing induces a tolerogenic phenotype in dendritic cells
J. Reyes-Martínez, Alma D Chávez-Blanco, T. Santos-Mendoza, J. Serafín-López, C. Sandoval-Montes, L. Flores-Romo,
S. Estrada-Parra, I. Estrada-García, R. Chacón-Salinas;
Mexico City, Mexico
315
P4.05.19 - Macrophage exposure to crystalline silica promotes growth of Mycobacterium tuberculosis by deregulating cell
death pathways
Leslie Chávez-Galán, L. Torre-Bouscoulet, R. Pérez-Padilla, A. Ramírez-Venegas, I. Sada-Ovalle;
Distrito Federal, Mexico
316
P4.05.20 - Mycobacterium tuberculosis impairs autophagic flux in human dendritic cells by ESX-1
M. Etna, A. Romagnoli, E. Giacomini, M. Pardini, M. Corazzari, R. Simeone, R. Brosch, G. Fimia, Eliana M. Coccia;
Rome, Italy
317
P4.05.21 - Virulence, immunopathology and transmissibility of selected strains of M. tuberculosis from epidemiological
studies in Colombia evaluated in a murine model
María F. Cornejo, J. Robledo, D. Mata, B. Marquina, J. Barrios, L.F. García;
Mexico City, Mexico
318
P4.05.22 - Induction of Transcription Factors involved in T lymphocyte differentiation in BCG vaccinated subjects and pulmonary Tuberculosis patients with antituberculosis therapy
Nancy E. Corral-Fernandez, N. Cortez-Espinosa, M. Salgado-Bustamante, S. Romano-Moreno, S.E. Medellín-Garibay,
B. Hernández-Castro, J.J. Macias-Mendoza, R. González-Amaro, D.P. Portales-Perez;
San Luis Potosí, Mexico
319
P4.05.23 - A partly normalization in the immune-endocrine circulating profile of tuberculosis patients undergoing specific
treatment
A. Diaz, B. Bongiovanni, L. D’Attilio, N. Santucci, G. Dídoli, S. Radcliffe, N. Brandan, L. Nannini, O.A. Bottasso, Maria Luisa Bay;
Rosario, Argentina
320
P4.05.24 - Mycobacterium bovis culture filtrate proteins induces expression of autocrine prolactin loop enhancing
inflammatory response in monocytes THP1
Ciro Estrada, G. López, A. Pereira;
Guadalajara, Mexico
134
Posters - August 24
321
P4.05.25 - Immunogenicity assessment of live TB vaccine candidates in human primary dendritic cells
Marilena P. Etna, E. Giacomini, M. Pardini, M. Severa, D. Bottai, R. Brosch, E.M. Coccia;
Rome, Italy
322
P4.05.26 - B cells are important to modulate the immune response against Mycobacterium tuberculosis (Mtb) in mice
Isabela C. Fontoura, A. Gembre, É. Padilha, T. Malardo, A.A.M. Coelho-Castelo;
Ribeirão Preto, Brazil
323
P4.05.27 - Mycobacterium leprae DNA and cytokine profile of household contacts resident in Governador Valadares, MG,
Brazil
R.S. Gama, P. Marçal, R. Cypriano, A. Castelo Branco, E.N. Sarno, M.O. Moraes, Lucia A.O. Fraga;
Governador Valadares , Minas Gerais, Brazil
324
P4.05.28 - Apoptotic body like liposomes carrying phosphatidic acid enhance antimicrobial and anti-inflammatory innate
immune response
E. Greco, M.B. Santucci, F. Taus, A. Serafino, A. Ciccaglione, N. Caccamo, R. Nisini, F. Dieli, T.H. Ottenhoff, Maurizio Fraziano;
Rome, Italy
325
P4.05.29 - Proteomics reveals dynamic phagosomal environment during Mycobacterium -HIV co-infection
Rakesh Ganji, S. Dhali, A. Rizvi, S. Rapole, S. Banerjee;
Hyderabad, India
326
P4.05.31 - CD4+ and CD8+ T cells producing IL-17 specific-ESAT-6 or CFP10 M.tuberculosis antigens correlate with therapy
successful in MDR-TB patients
Yolanda Gonzalez, M.A. Vega Popotla, M. Muñoz-Torrico, M. Salazar Lezama, M. Torres;
Mexico City, Mexico
327
P4.05.32 - Attenuation of BCG Delays Cell-to-Cell Spread in the Lung and Promotes its Clearance by T cells
Patricia Grace, J. Ernst;
New York, United States
328
P4.05.33 - IFN-α adjuvant effect in BCG-vaccinated mice against mycobacterial infections
M. Godinez Flores, O. Rojas-Espinoza, S. Giovana, R. Hernandez Pando, L. Gabriele, Gloria G. Guerrero;
Zacatecas, Mexico
329
P4.05.34 - Analysis of polymorphisms in TLRs and FcgRs in susceptibility to tuberculosis in a Mexican population
Sujhey Hernández Bazán, B. Sánchez, E. Ortega;
D. F., Mexico
330
P4.05.35 - Cathepsin S at the crossroads between innate and adaptive immunity to TB infection
A. Lau, V. Singh, A. Talal, Zakaria Hmama;
Vancouver, Canada
331
P4.05.36 - Prime-boost Mycobacterium smegmatis recombinant vaccination improves protection in mice infected with
Mycobacterium tuberculosis by enhancing humoral and cellular specific immune responses
Ana Paula Junqueira-Kipnis, F.M. Oliveira, M.M. Trentini, J.A. de Araújo Fliho, A. Kipnis;
Goiania, Brazil
332
P4.05.37 - Blockade of PD-1 signal pathway causes exacerbation of Mycobacterium tuberculosis infection via excessive
IFN-γ production by antigen-specific Th1 type CD4+ T cells
Ikuo Kawamura, M. Mitsuyama;
Kyoto, Japan
333
P4.05.38 - Anti-Interferon-Gamma Autoantibodies in Adults with Disseminated Nontuberculous Mycobacterial Infections
are Associated with HLA-DRB1*16:02 and DQB1*05:02 and the Reactivation of Latent Varicella-Zoster Virus Infection
C. Chi, C. Chu, C. Lin, J. Liu, Cheng- L. Ku;
Taoyuan, Taiwan
334
P4.05.39 - Mycobacterium tuberculosis Dos Regulon Gene Rv0079 Encodes a Putative, ‘Dormancy Associated Translation
Inhibitor (DATIN)’ and Induce Proinflammatory Responses
Ashutosh Kumar, M. Majid, A. Lewin, I.A. Qureshi, N. Ahmed;
Hyderabad, India
335
P4.05.40 - Protection evaluation following vaccination with a Mycobacterium abscessus virulence factor in a pulmonary
infection cftr-/- mice model
Vincent Le Moigne, C. Goulard, B. Barteau, M. Rottman, A. Roux, B. Pitard, J. Herrmann, J. Gaillard;
Montigny-le-Bretonneux, France
336
P4.05.41 - Association between DC-SIGN genetic variants and pulmonary tuberculosis in Chinese Uighurs
Dan Liu, L. Zhang, C. Peng, Y. Min, H. Wang, H. Wang;
Shanghai, China
337
P4.05.42 - Mycobacterium bovis culture filtrate proteins induces expression of autocrine prolactin loop enhancing
inflammatory response in monocytes THP1
Gonzalo López, C. Estrada, A. Pereira;
Guadalajara, Mexico
338
P4.05.43 - Suppression of immune regulation in a murine model of progressive pulmonary tuberculosis
Vasti Lozano Ordaz, M.M.B. Moreno Altamirano, R. Hernandez Pando;
México,DF, Mexico
339
P4.05.44 - Reduced frequency of BCG-specific IFN-γ Producing T Cells in Ugandan infants when Bacillus Calmette-Guerin
vaccination is delayed from birth to 6 Weeks Of Age
Fredrick Lutwama, B.M. Kagina, C. Day, A. Wajja, S. Kirimunda, M. Joloba, P. Musoke, T. Scriba, H. Mayanja-Kizza, W. Hanekom;
Cape Town, South Africa
135
Posters - August 24
340
P4.05.45 - Effects of multi-drug therapy (MDT) on cellular immunity in patients with leprosy
Patrick Marcinek, T. Engleitner, V. Thirumalaisamy Palanichamy;
Tübingen, Germany
341
P4.05.46 - The role of CD137 ligand (CD137L) signaling pathway during M. tuberculosis infection
Julia M. Martinez Gomez, V. Koh, W. Lin, M. Ang, Z. Zainul Rahim, H. Schwarz, S. Alonso;
Singapore, Singapore
342
P4.05.47 - Prolactin modulate proinflammatory inmune response induced by culture filtrate protein from Mycobacterium
bovis in THP1 cells through different signaling pathways
Priscila A. Martinez-Neri, G. Lopez-Rincon, J.F. Muñoz-Valle, E.I. Lopez-Pulido, C. Estrada-Chavez, A.L. Pereira-Suarez;
Guadalajara, Mexico
343
P4.05.48 - Human memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic
islands and are found in a CXCR3+CCR6+ Th1 subset
Federico Mele, C. Lindestam Arlehamn, B. Peters, A. Lanzavecchia, A. Sette, F. Sallusto;
Bellinzona, Switzerland
344
P4.05.49 - Plasma cytokines and chemokines differentiate between active disease and non-active tuberculosis infection
Adane Mihret, Y. Bekele, K. Bobosha, M. Kidd, A. Aseffa, R. Howe, G. Walzl;
Addis Ababa, Ethiopia
345
P4.05.50 - Knockdown of suppressor of cytokine signalling 3 mediates killing of Mycobacterium tuberculosis in THP1
derived macrophages
Mradul Mohan, A. Misra;
Lucknow, India
346
P4.05.51 - Association of SLC11A1 gene polymorphisms with susceptibility to Lepromatous Leprosy
Margarita Montoya-Buelna, J. Becerra-Contreras, M. Fafutis-Morris, E. Ochoa-Martínez, T. Reddy, L. Sandoval-Ramírez;
Guadalajara, Mexico
347
P4.05.52 - Mycobacterium tuberculosis P27 protein targets host cell mitochondria
María M. Bertha M.B. Moreno-Altamirano, C. Espitia, I. Paredes-Gonzalez;
Mexico, City, Mexico
348
P4.05.54 - The accumulation of highly differentiated Mtb-specific CD4 T cells is associated with lung tissue destruction
during pulmonary tuberculosis
Irina Y. Nikitina, A.V. Panteleev, R.B. Amansahedov, V.V. Ganusov, I.A. Vasilyeva, I.V. Lyadova;
Moscow, Russian Federation
349
P4.05.55 - Mycobacterium tuberculosis adapts its immune-evasion mechanisms in dependence of the antigen presenting
cell and shifting to dormancy
Roberto Nisini, M. Pardini, M. Gagliardi, F. Giannoni, F. Lozupone, R. Teloni, M. Fraziano, S. Meschini, S. Mariotti;
Rome, Italy
350
P4.05.56 - A novel therapeutic vaccine against tuberculosis using the cynomolgus monkey model and mice
Masaji Okada, Y. Kita, S. Hashimoto, H. Nakatani, S. Nishimatsu, Y. Kioka, T. Nakajima, Y. Kaneda, M. Cang, D. McMurray;
Sakai, Japan
351
P4.05.57 - Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients
Ariane L. Oliveira, T.P. Amadeu, A.C.d. Gomes, V.M. Menezes, J.A.d. Nery, R.O. Pinheiro, E.N. Sarno;
Rio de Janeiro, Brazil
352
P4.05.59 - M2-like polarization of Mycobacterium tuberculosis infected human macrophages by extracellular AMP
Laetitia Petit-Jentreau, N. Dubois-Colas, L.B. Barreiro, S. Durand, G. Soubigou, K. Rezaï, F. Lokiec, J. Coppée, B. Gicquel, L. Tailleux;
Paris, France
353
P4.05.60 - Differences in the levels of host markers detected in saliva and serum and their potential for diagnosing TB
disease
Khutso G. Phalane, M. Kriel, A.G. Loxton, A. Menezes, K. Stanley, G.D. van der Spuy, G. Walzl, N.N. Chegou;
Cape Town, South Africa
354
P4.05.61 - Different immunosuppressive mechanisms in multi-drug-resistant tuberculosis and non-tuberculous mycobacteria
patients
Roberta O. Pinheiro, E.B. Oliveira, G. dos Santos, G.M. Sperandio da Silva, B.J.A. Silva, A. Milagres, E.N. Sarno, M.P. Dalcolmo,
E.P. Sampaio;
Rio de Janeiro, Brazil
355
P4.05.62 - Increase of Reactive Oxygen Species in Natural Killer cells from Pulmonary Tuberculosis patients
D. Silva, M. Abreu, M. Ferreira-Teixeira, P. Couceiro, I. Ladeira, F. Viveiros, R. Duarte, H. Sá, Paulo Rodrigues-Santos;
Coimbra, Portugal
356
P4.05.63 - Fatty acid, cytokines and chemokines profile in exhaled breath condensates (EBCs) of patients with Tuberculosis
S. Mosquera-Restrepo, A. Caro-Zapata, C. Peláez-Jaramillo, Mauricio Rojas-Lopez;
Medellín, Colombia
357
P4.05.64 - Profiles of fatty acids released during the differentiation of mononuclear phagocytes in the presence of
mycobacterium tuberculosis - stearic acid effect on Differentiation
A. Caro-Zapata, S. Mosquera-Restrepo, C. Pelaez-Jaramillo, Mauricio Rojas-Lopez;
Medellín, Colombia
358
P4.05.65 - The combined use of M. tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active
tuberculosis
Virginie Rozot, S. Viganò, J. Mazza-Stalder, C. Day, C. Lazor-Blanchet, W. Hanekom, D. Goletti, L. Nicod, G. Pantaleo, A. Harari;
Lausanne, Switzerland
136
Posters - August 24
359
P4.05.66 - Functional and phenotypic characterization of Mycobacterium tuberculosis specific CD4+T cells in peripheral
blood and at the site of infection
Karima Sahmoudi, P. Ndishimye, M. Chair, A. El Habazi, J. Benamour, J. Bourkadi, K. Sadki, O. Lahlou, F. Seghrouchni, R. El Aouad;
Rabat, Morocco
360
P4.05.67 - NOD2 triggers an IL-32 dependent human dendritic cell program in leprosy
Mirjam Schenk, R.L. Modlin;
Los Angeles, United States
361
P4.05.68 - The role of follicular helper T cells in mycobacterial infection
Yoko Shimohakamada, T. Tamura, M. Makino, S.L. Nutt;
Higashimurayamashi, Japan
362
P4.05.69 - Specific TCD8+IL-10+ and TCD8+TGF-beta+ cells in active tuberculosis patients
Bruna Daniella S. Silva, M.M. Trentini, A.C. Costa, A.O. Costa-Júnior, A. Kipnis, A. Junqueira-Kipnis;
Goiânia, Brazil
363
P4.05.70 - Deciphering Dendritic Cell Function during Mycobacterium tuberculosis Infection by RNA Interference
Jhalak Singhal, K. Natarajan;
Delhi, India
364
P4.05.71 - Clinical isolates of Mycobacterium tuberculosis exacerbate pulmonary inflammation in mice
Elyara M. Soares, A. Secatto, C. Peres-Buzalaf, E.G. Soares, M. Palaci, C.L. Silva, L.H. Faccioli;
Ribeirão Preto, Brazil
365
P4.05.72 - Role of Slc11a1 gene in macrophage activation during BCG infection
P. Aguilar-Ramirez, W.H.K. Cabrera, J.R. Jensen, D. Rodriguez, L.C.C. Leite, O.G. Ribeiro, M. De Franco, O.C.M. Ibañez,
Nancy Starobinas;
São Paulo, Brazil
366
P4.05.73 - Development of a new point-of-care test for leprosy
L.P.V. Cardoso, A.A. Freitas, E.M. Hungria, R.M. Oliveira, R.F. Dias, M. Collovati, S.G. Reed, M.S. Duthie, Mariane M. Stefani;
Goiania, Brazil
367
P4.05.74 - The involvement of proteins of DNA double-strand breaks repair systems of Mycobacterium tuberculosis
in the infection of human macrophages
Izabela Szulc, M. Brzezinska, M. Klink, A. Brzostek, M. Kielbik, Z. Sulowska, J. Dziadek;
Lodz, Poland
368
P4.05.75 - The role of Mycobacterium tuberculosis secreted protein in the induction of Th1 immune response
Toshiki Tamura, Y. Shimohakamada, M. Makino;
Higashimurayama, Japan
369
P4.05.77 - The interaction of CD43 with Mycobacterium tuberculosis Cpn60.2 modulates cytokines production
Alvaro Torres Huerta, C. Espitia, M.E. Cruz Muñoz, G. Pedraza Alva, Y. Rosenstein;
Cuernavaca, Mexico
370
P4.05.78 - Combined detection of IFNγ, TGFα and IL-6 c n discriminate between active TB disease and latent infection
Elena Vasilyeva, V. Verbov, I. Nikitina, I. Lyadova, A. Totolian;
Saint-Petersburg, Russian Federation
371
P4.05.79 - Modelling human granuloma to study the mechanisms by which isoniazid inhibits Mycobacterium tuberculosis
growth
Lívia H. Yamashiro, N.M. de Souza, M.D. Garcia, C. Eto, A. Báfica;
Florianópolis, Brazil
372
P4.05.80 - Aptamer against an immunosuppressive epitope-ManLAM inhibits virulent Mycobacterium tuberculosis
infection in mice and rhesus monkeys
Xiao-Lian Zhang, Q. Wang, Q. Pan, X. Xia, F. Luo;
Wuhan, China
P5.09 NEUROIMMUNOLOGY
Session Time: Saturday, August 24, 13:20 - 15:00
373
P5.09.01 - Nanotherapy for drug addiction
Ravikumar Aalinkeel, J. Reynolds, B. Nair, D. Sykes, W. Law, P. Prasad, S. Schwartz, S. Mahajan;
Buffalo, United States
374
P5.09.02 - Immunofluorescence patterns in mouse cerebellum and kidney tissues revealed by seric antibodies of patients
with various neuroinflammatory diseases
D.L. De la Cruz-Aguilera, J.E. Pablo-Gopar, J.J. Flores-Rivera, T. Corona, A. González-Aguilar, Maria L. Aguirre-Cruz;
México D. F., Mexico
375
P5.09.03 - Importance of the vagus nerve in immunodepression following stroke
Levent Akyüz, C. Dames, O. Engel, K. Winek, H.D. Volk, C. Meisel, A. Meisel;
Berlin, Germany
376
P5.09.04 - Expression of cytokines during the innate immune response in a model of hepatic amoebiasis in sympatectomized
hamsters
Manuel E. Avila-Blanco, M. Campos-Esparza, M.H. Muñoz-Ortega, A. Quintanar-Stephano, J. Ventura-Juarez;
Aguascalientes, Mexico
137
Posters - August 24
377
P5.09.05 - Detection of ANCA (Anti Neutrophil Cytoplasmic Antibodies) by indirect immunofluorescence / ELISA and related
neurological diseases: preliminary results on a Moroccan series
Siham Aziz, N. Tahiri Jouti, R. Ibn Moufti, H. Fellah, A. Naya, I. Slassi, S. Zamiati;
Casablanca, Morocco
378
P5.09.06 - Expression of the galanin system in immune cells: hypothetical key players of the immune response
Rodolfo Bianchini, A. Koller, A. Lang, B. Brodowicz, E. Müller, B. Kofler;
Salzburg, Austria
379
P5.09.07 - Blocking Glutamate Carboxypeptidase II Inhibited Glutamate Excitotoxicity and Regulated Immune Responses
in Experimental Autoimmune Encephalomyelitis
So Jin Bing, D. Ha, G. Ahn, J. Kim, J. Cho, S. Ahn Jo, Y. Jee;
Jeju, Korea, Republic of
380
P5.09.08 - A new concept to address inflammatory immune activation in neurological disorders
Patricia Bolaños, M. Schneider, K. Bechter, P. Walther, H. Raventós;
San José, Costa Rica
381
P5.09.09 - Astrocytes play a key role in EAE pathophysiology by facilitating CNS immune cell infiltration and suppressing
remyelination
Roberta Brambilla, J. Jopek Ashbaugh, P. Morton, S. Karmally, K.L. Lambertsen, J.R. Bethea;
Miami, United States
382
P5.09.10 - A single dose of Pirfenidone attenuates neuronal cell death after excitotoxic kainic acid-induced in rat hippocampus through inhibition of microglial activation, but not TNF-ɑ and IL-1β production
Rubén D. Castro Torres, V. Chaparro Huerta, M.E. Flores Soto, J. Armendáriz Borunda, C. Beas Zárate;
Guadalajara, Mexico
383
P5.09.11 - Increased expression of Toll-like receptors 7 and 9 in Epstein-Barr virus-infected myasthenia gravis thymus
Paola Cavalcante, S. Marcuzzo, S. Franzi, L. Maggi, C. Antozzi, F. Baggi, S. Berrih-Aknin, R. Mantegazza, P. Bernasconi;
Milan, Italy
384
P5.09.12 - Contact Hypersensitivity To Oxazolone Provokes Vulvar Mechanical Hyperalgesia In Mice
Devavani Chatterjea, T. Martinov, R. Glenn-Finer, E. Balsells;
Saint Paul, United States
385
P5.09.13 - Expression of dopamine receptor D3 on CD4+ T-cells favors Th1-mediated immunity
Francisco Contreras, C. Prado, H. González, D. Franz, D. Elgueta, R. Pacheco;
Santiago, Chile
386
P5.09.14 - Prolactin is dispensable for the development of experimental autoimmune encephalomyelitis
Massimo Costanza, S. Musio, N. Binart, M. Abou-Hamdan, R. Pedotti;
Milano, Italy
387
P5.09.15 - The immunogenicity of amyloid beta oligomers
Indre Dalgediene, R. Lasickiene, R. Budvytyte, G. Valincius, R. Morkuniene, V. Borutaite, A. Zvirbliene;
Vilnius, Lithuania
388
P5.09.16 - Enhanced susceptibility to pulmonary infections after experimental stroke
Claudia Dames, L. Akyüz, O. Engel, K. Winek, H. Volk, A. Meisel, C. Meisel;
Berlin, Germany
389
P5.09.17 - Regulatory T cells delay disease progression in a murine model of Alzheimer’s disease
Cira Dansokho, C. Toly-Ndour, S. Aïd, T. Chaigneau, M. Holzenberger, P. Aucouturier, G. Dorothee;
Paris, France
390
P5.09.18 - Possible role of nerve-glial antigen 2(NG2) in the development of experimental autoimmune encephalomyelitis
Giovanni Ferrara, S. Morando, F. Girolamo, M. Errede, N. Kerlero de Rosbo, R. Perris, R. Furlan, C. Bendotti, D. Virgintino, A. Uccelli;
Genoa, Italy
391
P5.09.19 - Dopamine regulates the induction of Cytotoxic T-Lymphocyte by stimulation of dopamine receptor D3
expressed on CD8+ T-cells and on dendritic cells
Claudio A. Figueroa, F. Contreras, G. Fuentealba, C. Prado, R. Pacheco;
Santiago, Chile
392
P5.09.20 - ATP-mediated interaction between astrocytes and T cells
Fabia Filipello;
Milan, Italy
393
P5.09.21 - Experimental studies of narcolepsy immunopathogenesis in HLA-DQB1*0602 transgenic mice
Tobias L. Freitag, K. Zitting, A. Kipar, I. Julkunen, T. Hökfelt, T. Stenberg, S. Meri;
University of Helsinki, Finland
394
P5.09.22 - Schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene
Hovsep Ghazaryan, A. Boyajyan, R. Zakharyan, A. Melkonyan, Z. Navratilaova, P. Klevcova, M. Petrek;
Yerevan, Armenia
395
P5.09.23 - Schizophrenia is not associated with changes in blood expression levels of complement factors B, H and I
Hovsep Ghazaryan, A. Boyajyan, R. Zakharyan, A. Melkonyan, Z. Navratilaova, P. Klevcova, M. Petrek;
Yerevan, Armenia
396
P5.09.24 - IL-18 and IL-18BP in Amyotrophic Lateral Sclerosis
P. Giungato, P. Italiani, P. Migliorini, G. Siciliano, B. Borroni, P. Bossù, Diana Boraschi;
Pisa, Italy
138
Posters - August 24
397
P5.09.25 - Using the sodium salt of native DNA as an immunomodulator in the treatment of different diseases
Anatoliy P. Godovalov, T.Y. Danielyan, N.A. Danielyan, A.A. Danielyan;
Perm, Russian Federation
398
P5.09.26 - Prevalence and evolution of Autoimmune Diseases in patients with Cushing’s Syndrome compared to other
Pituitary Tumors: a Multicenter Italian Study
Federica Guaraldi, M. De Martin, C. Scaroni, M. Zilio, F. Pecori Giraldi, I. Karamouzis, S. Grottoli, L. Ghizzoni, E. Ghigo, E. Arvat;
Turin, Italy
399
P5.09.27 - Measuring cerebrospinal fluid (CSF) immunoglobulins in neurological conditions
Yael Hacohen, V. Forsyth, G. Swana, M. Absoud, M. Lim;
Oxford, United Kingdom
400
P5.09.28 - Expression of selected Th1/Th2 transcription factors and immune-response genes in cerebral ischemia and
senescence
Anahit Hakobjanyan, A. Boyajyan, L. Hovsepyan, Z. Navratilova, P. Klevcova, M. Petrek;
Yerevan, Armenia
401
P5.09.31 - Regulation of microglia activation mechanisms following chemical or mechanical stimulation
Maria Kalognomou, C. Simitzi, I. Athanassakis;
Heraklion, Greece
402
P5.09.32 - Macrophage migration inhibitory factor has an essential role in age-related hearing loss
Shin Kariya, M. Okano, Y. Maeda, Y. Noyama, T. Haruna, T. Koyama, K. Nishizaki;
Okayama, Japan
403
P5.09.33 - Evaluation of multiple sclerosis (MS) based on Antibody to Aquaporine-4(AQP-4) in urine and serum compared
to total IgG antibody
Afra Khosravi, M. Mohamad-Rashidi;
Ilam, Iran, Islamic Republic of
404
P5.09.34 - The inner ear findings in macrophage migration inhibitory factor knockout mice
Takahisa Koyama, S. Kariya, M. Okano, Y. Maeda, T. Haruna, Y. Noyama, K. Nishizaki;
Okayama, Japan
405
P5.09.35 - Participation of cold sensitive TRPM8 ion channel in modulation of metabolism and immune response
Tamara V. Kozyreva;
Novosibirsk, Russian Federation
406
P5.09.36 - Chronic co-administration of risperidone (RIS) and fluoxetine (FLU) modulates behavior of mice in forced
swimming test (FST) and cytokine production by splenocytes
Justyna Kusmierczyk, E. Klimek, A. Roman, Z. Rogoz, I. Nalepa;
Krakow, Poland
407
P5.09.37 - High prevalence of anti-neuronal antibodies in Tunisian psychiatric inpatients
Lilia Laadhar, O. Sidhom, M. Zitouni, N. Sassi, M. Kallel-Sellami, Z. El Hechimi, S. Makni;
Tunis, Tunisia
408
P5.09.38 - Usefulness of pituitary antibodies in the management non-tumoral pituitary diseases in Tunisian adults
Lilia Laadhar, M. Chihaoui, M. Kallel-Sellami, N. Sassi, B. Ftouhi, H. Lahmar, F. Kanoun, H. Slimane, S. Makni;
Tunis, Tunisia
409
P5.09.39 - Idiopathic hypertrophic cranial pachymeningitis: a rare inflammatory cause of chronic daily headache and
progressive cranial neuropathies: a case report
Mary Grace B. Laguerta, E.A. Esposo, B. Mariano, M. Martinez;
Quezon city, Philippines
410
P5.09.40 - Immune signatures to predict the development and progression of Alzheimer’s disease: lymphocyte profiles
Aurélie Y. Le Page, E.H. Frost, G. Dupuis, T. Fülöp;
Sherbrooke, Canada
411
P5.09.41 - Patients with febrile infection-related epilepsy and other syndromes and microtubule-associated tau protein data
Yevgeniya Lekomtseva, G. Gubina-Vakulik, T. Gorbach;
Kharkiv, Ukraine
412
P5.09.43 - Activation of exploratory behavior in senescence accelerated OXYS rats by stimulation of cell-mediated
immune response with BCG vaccine
Evgeniya V. Markova, N.G. Kolosova, V.A. Kozlov;
Novosibirsk, Russian Federation
413
P5.09.44 - Effects of transplantation of the immune cells treated with psycho modulators on the nervous system
functional activity of recipients
Evgeniya V. Markova, M.A. Knyazheva, V.A. Kozlov;
Novosibirsk, Russian Federation
414
P5.09.45 - Characterization and role of the humoral response after transplantation of porcine neuroblasts in the rat brain
Elodie Mathieux, V. Nerriere-Daguin, X. Leveque, S. Menoret, I. Anegon, I. Neveu, P. Naveilhan;
Nantes, France
415
P5.09.46 - Neuronal toll-like receptor-4 signalling induces brain endothelial cell activation and neutrophil transmigration
Samaneh Maysami, S. Leow-Dyke, C. Allen, A. Danes, O. Nilsson, A. Bowie, N. Rothwell, E. Pinteaux;
Manchester, United Kingdom
416
P5.09.47 - TLR-2 but not TLR-9 is up-regulated in the Central Nervous System and Lymphoid Organs during Canine Visceral
Leishmaniasis
Guilherme D. Melo, F.G. Grano, J.E.S. Silva, A. Schweigert, J.R. Peiró, V.M.F. Lima, G.F. Machado;
Araçatuba, Brazil
139
Posters - August 24
417
P5.09.48 - Impact of neurturin on allergic airway inflammation in mice
M. Mauffray, O. Domingues, J. Zimmer, F. Hentges, D. Hanau, Tatiana Michel;
Luxembourg, Luxembourg
418
P5.09.49 - Novel magnetic resonance imaging approaches for monitoring neuroinflammation
Jason M. Millward, M. Taupitz, J. Schnorr, S. Wagner, J.T. Wuerfel, K. Riek, J. Braun, F. Paul, I. Sack, C. Infante-Duarte;
Berlin, Germany
419
P5.09.50 - A forebrain-immune cell pathway for the maintenance of CNS immune tolerance
Mohammad G. Mohammad, V.W.W. Tsai, H. Li, M.G. Hassanpour, S.N. Breit, P.H. Hart, P.E. Sawchenko, D.A. Brown;
Sydney, Australia
420
P5.09.51 - Immunomodulatory effects of Interleukin-27 on active experimental autoimmune encephalomyelitis
Mohammad S. Mojadadi Mehrabadi, M. Ebtekar, M. Golkar, H. Khan Ahmad;
Sabzevar, Iran, Islamic Republic of
421
P5.09.52 - Synaptic deficits in sepsis: Role of glial cells
Carolina A. Moraes, G. Santos, J. D’Avila, P. Perdigao, C. Benjamin, F. Bozza, F. Gomes;
Rio de Janeiro, Brazil
422
P5.09.53 - Day and Night Alterations of serum melatonin, MIP-1α, MCP-1 and IL-17A levels in multiple sclerosis
Ugur Musabak, G. Genc, S. Demirkaya, R.S. Ilikci, O. Kartal, M. Gulec, O. Sener;
Etlik, Turkey
423
P5.09.54 - Identifying Biomarkers Associated with Pain in Swine using an In Vitro Inflammation Model
C.M. Deaver, E. Kenyon, S.M. Peters, M. Prescott, H.L. Swaim, K. Tanke, H.F. Yancy, Michael J. Myers;
Laurel, United States
424
P5.09.55 - Dopamine receptor D3 expressed on CD4+ T-cells favours neurodegeneration of dopaminergic neurons during
Parkinson’s disease
Rodrigo Pacheco, H. González, F. Contreras, C. Prado, D. Elgueta, D. Franz;
Santiago, Chile
425
P5.09.56 - Clinical cases of immune-mediated partial epilepsy
Tetiana Pertseva;
Kharkiv, Ukraine
426
P5.09.57 - NMR Metabolomics: a Diagnostic Tool for Multiple Sclerosis
T. Gebregiworgis, C. Massilamany, A. Gangaplara, H. Nielssen, M. Werth, D. Steffen, R. Zabad, Z. Illes, R. Powers, Jay Reddy;
Lincoln, United States
427
P5.09.58 - Influence of LRRK2 G2019 mutation on peripheral B cells from Parkinson’s disease patients
Gustavo R. Rossi, M. Kubo, M. Gonçalves, P. Rodrigues-Santos, C. Januário, F. Obata, R. de Carvalho, M. Souto-Carneiro;
Curitiba, Brazil
428
P5.09.59 - Anti-ganglioside antibodies in Pandemrix®-induced narcolepsy
Anna-Helena Saariaho, O. Vaarala, M. Partinen, S. Meri;
Helsinki, Finland
429
P5.09.60 - Effects of vagotomy during inflammation and cytokine production in hamster amebic liver abscess
Esperanza Sánchez Alemán, A. Quintanar-Stephano, M. Campos-Esparza, J. Ventura-Juarez;
Aguascalientes, Ags., Mexico
430
P5.09.61 - Steroids hormones on neurofibromas development
Alessandra Santos, M. Geller, S.G. Mezitis, M. Ribeiro, L. Oliveira, K. Cunha, A. Fonseca, R.S. Batista, A.P. Gomes, G. Darrigo;
Rio de Janeiro, Brazil
431
P5.09.62 - Cocaine exposure, abstinence and relapse differentially affect dopaminergic, mu-opioid and CB2 receptors
expression on immune cells
Raquel Santos-Toscano, A. Higuera-Matas, M. Ucha, D. Roura-Martínez, J. Fernández-Ruiz, M. Miguéns, E. Ambrosio, M.A. Assis;
Madrid, Spain
432
P5.09.64 - Immune response in dorsal root ganglion of mice infected with Herpes Simplex-1 (HSV-1) leads to the
development of hyperalgesic behaviour
Jaqueline R. Silva, A.H.P. Lopes, J. Talbot, R.F.O. França, B.A.L. Fonseca, T.M. Cunha, F.Q. Cunha;
Ribeirão Preto, Brazil
433
P5.09.65 - IFN-ɣ is protective in EAE by activating CNS-resident microglia to phagocytose neurotoxic myelin debris
Rebecca A. Sosa, A.E. Cardona, T.G. Forsthuber;
San Antonio, United States
434
P5.09.66 - Influenza split vaccine in regulation of autoimmune processes in experimental autoimmune encephalomyelitis
Aleksandra Stojkovic, D. Kosanovic, N. Vukov, K. Jovanova-Nesic;
Belgrade, Serbia
435
P5.09.67 - Evaluation of Tumor necrosis factor (TNF-α) cascade in the brain of rat model of collagen-induced arthritis (CIA)
Roba M. Talaat, A.S. Abo-Elatta;
Sadat city, Egypt
436
437
140
P5.09.68 - Microglia induced Foxp3+CD4+Treg through PD-L1 in experimental autoimmune encephalomyelitis
J. Hu, H. He, G. Zhu, W. Song, B. Bai, Hua Tang;
Taian, China
P5.09.69 - Gene expression upregulation of TNF superfamily members in temporal lobe epilepsy-associated hippocampal
sclerosis
Marcelo A. Teocchi, L. D’Souza-Li;
Campinas, Brazil
Posters - August 24
438
P5.09.71 - The effect of exogenously administered charged microparticles on the acute phase response
Shiqing Wang, Y. Couch, G. Bort, B. Davis, D. Anthony;
Oxfordshire, United Kingdom
439
P5.09.73 - The function of TREM2 mutants
Yoshinori Yamanishi, M. Colonna;
St. Louis, United States
440
P5.09.74 - Induction of upregulated expression of histamine receptors and increased release of inflammatory mediators
from microglia by histamine
Shu Zhang, X. Zeng, S. He;
Nanjing, China
P5.10 MULTIPLE SCLEROSIS
Session Time: Saturday, August 24, 13:20 - 15:00
441
P5.10.01 - The prokineticin system in experimental autoimmune encephalomyelitis: possible novel targets for immune
intervention
Mhamad Abou-Hamdan, M. Costanza, E. Fontana, M. Di Dario, S. Musio, L. Negri, P. Poliani, C. Farina, G. Balboni, R. Pedotti;
Milan, Italy
442
P5.10.02 - Immunopathological patterns in relapsing-remitting and chronic models of experimental autoimmune
enchephalomyelitis and the therapeitc effect of glatiramer acetate
Rina Aharoni, R. Eilam, R. Arnon;
Rehovot, Israel
443
P5.10.03 - Association of SNP rs6897932 in CD127 gene in Relapsing Remitting Multiple Sclerosis (RRMS) patients
compared to control group
Fereshteh Alesahebfosoul, R. Salehi, A. Zavaran Hosseini, M. Etemadifar, M. Kazemi, M. Tajedin, B. Zarkeshfard;
Tehran, Iran, Islamic Republic of
444
P5.10.04 - Frequency of null allele of HLA-G Locus in East Azarbayjan patients with recurrent miscarriage
Nazila Alizadeh Gharamaleki;
Tabriz, Iran, Islamic Republic of
445
P5.10.05 - Th1/Th17 imbalance in clinical subtypes of Multiple Sclerosis: association with disability and unresponsiveness
to IFN-β therapy in relapsing-remitting disease
Gabriel Arellano, E. Acuña, L. Reyes, F. Vergara, R. Uribe, E. Ciampi, C. Cárcamo, R. Naves;
Santiago, Chile
446
P5.10.06 - The role of STI-571 in the treatment of EAE
Gholamreza Azizi, A. Mirshafiey;
karaj, Iran, Islamic Republic of
447
P5.10.07 - Interleukin-17A and Interleukin-17F mRNA Expressions in Peripheral Blood Mononuclear Cells of Patients with
Multiple Sclerosis
Farhad Babaei, Z. Babaloo, M. Farhoodi;
Tabriz, Iran, Islamic Republic of
448
P5.10.08 - Inflammatory stimuli and oxidative stress alter mitochondrial transport in neurons
Elena Bros, R. Niesner, F. Paul, C. Infante Duarte;
Berlin, Germany
449
P5.10.09 - A systems biology approach to identify biomarkers and therapeutic targets in peripheral monocytes of multiple
sclerosis patients
Ilaria Burba, S. Baldassarri, A. Torri, S. Fumagalli, C. Ripamonti, D. Caputo, M. Rovaris, M. Foti;
Milan, Italy
450
P5.10.10 - Micro/nanoparticles platforms for “inverse vaccination” in Experimental Autoimmune Encephalomyelitis (EAE)
Giuseppe Cappellano, A. Demeke Woldetsadik, Y. Shivakumar, M. Rizzi, F. Carniato, E. Orilieri, A. Chiocchetti, F. Renò, U. Dianzani;
Novara, Italy
451
P5.10.11 - In-vitro up-regulation of Regulatory T cells markers with IFN-beta and c-Phycocyanin: pertinence of a combined
treatment for Multiple Sclerosis
Majel Cervantes-Llanos, R. Alonso-Ramírez, G. Martínez-Sánchez, J. Cabrera-Gómez, C. Valenzuela-Silva, A. Llópiz-Arzuaga,
A. Milian-Jordan, E. De Armas, P. López-Saura, G. Pentón-Rol;
La Habana, Cuba
452
P5.10.12 - Complex changes in invariant natural killer T (iNKT) cells in patients with different clinical forms and treatments
of multiple sclerosis
Sara De Biasi, M. Nasi, A. Simone, D. Ferraro, F. Vitetta, L. Gibellini, M. Pinti, C. Del Giovane, P. Sola, A. Cossarizza;
Modena, Italy
453
P5.10.13 - MBP85-99 specific TCR repertoire in DRB1*15 patients affected by Multiple Sclerosis
Gabriele Di Sante, S. Rolla, A. Patanella, G. Migliara, A. Piermattei, M. Valentini, A. Batocchi, M. Mirabella, F. Novelli, F. Ria;
Rome, Italy
454
455
P5.10.14 - Frequency of Myelin Oligodendrocyte Glycoprotein (MOG) specific B cells in the blood and the CSF of patients
with Multiple Sclerosis (MS)
Annie Elong Ngono, F. Guillot, A. Garcia, A. Genty, M. Salou, N. Degauque, A. Nicot, S. Brouard, D. Laplaud, J. Soulillou;
Nantes, France
P5.10.15 - Effector T cell depolarization after glucocorticoid treatment impairs migration and APC conjugate formation
Henrike J. Fischer, N. Müller, H.M. Reichardt;
Göttingen, Germany
141
Posters - August 24
456
P5.10.16 - The atypical antipsychotic agents, clozapine and risperidone, reduce disease severity in the animal model of
multiple sclerosis
Laura K. Green, M. Kharkrang, D. O’Sullivan, B. Conner, A.C. La Flamme;
Wellington, New Zealand
457
P5.10.17 - Development and assessment of multifunctional gold nanoparticle system for dendritic cell targeting in the
treatment of EAE
D Haghmorad, M.B. Mahmoudi, M. Hosseini, N. Tabasi, S. Zamani, M. Rastin, M. Mahmoudi;
Mashhad, Iran, Islamic Republic of
458
P5.10.18 - 1, 25-dihydroxyvitamin D3 ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice
D Haghmorad, M.B. Mahmoudi, A. Amini, N. Tabasi, S. Zamani, M. Rastin, M. Mahmoudi;
Mashhad, Iran, Islamic Republic of
459
P5.10.19 - miR-132 suppresses autoimmune encephalomyelitis by inducing cholinergic anti-inflammation: a novel Ahr-based
exploration
Hamza Hanieh, A. Alzahrani;
Alhasa, Saudi Arabia
460
P5.10.20 - Study of the frequency of different CD8+ T cell subsets in patients with Multiple Sclerosis
Maryam Izad, Z. Salehi, M. Sahraian, E. Janzamin, R. Doosti, P. Khosravani;
Tehran, Iran, Islamic Republic of
461
P5.10.21 - Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis
and its correlation with severity of symptoms
Azam Jamshidian, M. Gharagozloo, V. Shaygannejad, A. Pourazar, S. Zarkesh;
Isfahan, Iran, Islamic Republic of
462
P5.10.22 - Vav1 influences susceptibility to central nervous system autoimmunity
Sahar Kassem, C. Colacios, A. Dejean, G. J Fournié, B. Malissen, A. Saoudi;
Toulouse, France
463
P5.10.23 - Microglia are potent producers of IFNβ in the context of autoimmunity and microbial stimulation
Magdalena Kocur, R. Schneider, A. Pulm, J. Bauer, S. Kropp, J. Alferink, T. Prozorovski, O. Aktas, S. Scheu;
Duesseldorf, Germany
464
P5.10.24 - Month of Birth, Vitamin D and Risk of Immune Mediated Disease
Elham Zare
465
P5.10.25 - NK cells are functionally defective in multiple sclerosis
Alice Laroni, R. Gandhi, E. Armentani, I. Gandoglia, F. Ivaldi, G.L. Mancardi, H.L. Weiner, A. Uccelli;
Genoa, Italy
466
P5.10.26 - Multiple sclerosis mesenchymal stromal cells exhibit a distinct gene profile and decreased immunosuppressive
properties in relation to healthy control cells
Gislane Lelis Vilela de Oliveirra, K.C.R. Malmegrim, K.W.A. Lima, D.G. Ribeiro, A. Colombini, D.T. Covas, J.C. Voltarelli, E.A. Donadi;
Ribeirão Preto, Brazil
467
P5.10.27 - The regulation synthesis and hydrolysis of cGMP in brain cortex rats during the course of experimental
autoimmune encephalomyelitis (EAE)
Natalia Lubina-D browska, G. Sulkowski, K. Turska, J. Langfort, A. St pie , M. Chalimoniuk;
Warsaw, Poland
468
P5.10.28 - Natural killer cells in early multiple sclerosis
Helena Mareckova, L. Skacikova, Z. Hruskova, D. Horakova, E. Havrdova;
Prague 2, Czech Republic
469
P5.10.29 - Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling
Aram Mokarizadeh;
Sanandaj, Iran, Islamic Republic of
470
P5.10.30 - The association of Epstein-Barr virus infection with multiple sclerosis
Adeleh Najafipoor, R. Roghanian;
Isfahan, Iran, Islamic Republic of
471
P5.10.31 - Monomethyl fumarate induces a switch of activated microglia from a pro-inflammatory to a neuroprotective
phenotype
Benedetta Parodi, C. Cordano, D. Giunti, C. Usai, N. Kerlero De Rosbo, R.H. Scannevin, A. Uccelli;
Genoa, Italy
472
P5.10.32 - Deficiency of CD8 effector memory T cells impairs response to Epstein-Barr virus in multiple sclerosis
Michael P. Pender, P.A. Csurhes, C.M.M. Pfluger, S.R. Burrows;
Brisbane, Australia
473
P5.10.33 - Investigating the causes of A20 down-regulation in Multiple Sclerosis: genetic mechanisms and hormonal modulations
Simona Perga, S. Martire, N.D. Navone, F. Montarolo, P. Berchialla, A. Bertolotto;
Orbassano, Italy
474
P5.10.34 - Increased CD8+ T Cell Response to Epstein-Barr Virus Lytic Antigens in the Active Phase of Multiple Sclerosis
Eleonora Piras, B. Serafini, C. Gasperini, R. Mechelli, M. Salvetti, D. Centonze, G. Borsellino, F. Aloisi, L. Battistini, D. Angelini;
Rome, Italy
475
P5.10.35 - Dysfunction of gene expression in B cells from patients with multiple sclerosis
Claudia Policano, V. Annibali, R. Umeton, A. Annese, A. Palermo, R. Mechelli, M. Buscarinu, G. Mattei, G. Ristori, M. Salvetti;
Rome, Italy
142
Posters - August 24
476
P5.10.36 - The role of Chlamydia pneumonia in Multiple Sclerosis
Maryam Rahimi, R. Roghanian;
Isfahan, Iran, Islamic Republic of
477
P5.10.37 - T cell repertoire analyses and comparison between blood, CSF and CNS lesions in patients with Multiple Sclerosis
M. Salou, A. Gainche-Salmon, L. Michel, D. Loussouarn, A. Garcia, S. Wiertlewski, J. Soulillou, S. Brouard, N. Degauque, D. Laplaud,
Hoa Mai Le;
Nantes, France
478
P5.10.38 - Expression of Th1/Th17-related genes in IFN-β-treated relapsing-remitting multiple sclerosis patients
Emina Savic, M. Markovic, J. Drulovic, I. Dujmovic Basuroski, S. Mesaros, V. Pravica, D. Popadic, M. Mostarica Stojkovic;
Belgrade, Serbia
479
P5.10.39 - The vitamin D and expression of IL-10 and NF-KB genes in Iranian multiple sclerosis patients
Zeinab Shirvani Farsani, M. Behmanesh, M. Sahraian, R. Doosti;
Tehran, Iran, Islamic Republic of
480
P5.10.40 - Alpha-melanocyte-stimulating hormone (α-MSH) inhibits the development and progression of autoimmune
encephalomyelitis by generating functional regulatory T cells
Nadine Sucker, L. Klenner, S. Laggies, C. Bürger, T. Luger, K. Loser;
Münster, Germany
481
P5.10.41 - Regulatory T-cells in relapsing-remitting multiple sclerosis patients: Effect of disease activity and treatment
regimens
N. Dimisianos, M. Rodi, D. Kalavrizioti, A. Lastic, P. Sakellaraki, Anthi Tapeinou, T. Tselios, J. Matsoukas, P. Papathanasopoulos,
A. Mouzaki;
Patras, Greece
482
P5.10.42 - Plasma biomarkers can discriminate among multiple sclerosis clinical forms
Marta Tejera-Alhambra, A. Casrouge, C. de Andrés, A. Seyfferth, R. Ramos-Medina, B. Alonso, J. Vega, M. Albert,
S. Sánchez-Ramón;
Madrid, Spain
483
P5.10.43 - Low DPP4 expression and activity in multiple sclerosis patients
Marta Tejera-Alhambra, A. Casrouge, C. de Andrés, R. Ramos-Medina, B. Alonso, J. Vega, M. Albert, S. Sánchez-Ramón;
Madrid, Spain
484
P5.10.44 - Andrographolide suppresses chronic and relapsing-remitting experimental autoimmune encephalomyelitis
Juan E. Tichauer, E. Molina, E. Acuña, R. Burgos, J. Hancke, C. Cárcamo, R. Naves;
Santiago, Chile
485
P5.10.45 - CD28 individual signals amplify pro-inflammatory cytokine production in relapse-remitting multiple sclerosis
T lymphocytes
Loretta Tuosto, C. Camperio, M. Muscolini, E. Volpe, R. Mechelli, S. Ruggieri, E. Piccolella, M. Salvetti, C. Gasperini, L. Battistini;
Rome, Italy
486
P5.10.46 - Antigen-presenting cells in the central nervous system in EAE
Agnieszka Wlodarczyk, M. Løbner, O. Cédile, T. Owens;
Odense, Denmark
487
P5.10.47 - Transforming growth factor beta and interleukin-10 in multiple sclerosis patients after intravenous infusion
of autologous mesenchymal stem cells
Marina Zafranskaya, H. Ivanchik, D. Nizheharodava, M. Yurkevich, Y. Motuzova, E. Selezneva, A. Borisov;
Minsk, Belarus
488
P5.10.48 - Characterization of immune cell infiltrates in the lesions of multiple sclerosis patients
Stephanie E.J. Zandee, M.D. Leech, A. Williams, S.M. Anderton;
Edinburgh, United Kingdom
489
P5.10.49 - Activated natural killer T cells recruit myeloid-derived suppressor cells to the central nervous system to
suppress multiple sclerosis-like disease
Daniel F. Zegarra Ruiz, V.V. Parekh, L. Van Kaer;
Lima, Peru
P5.22 PRIMARY IMMUNODEFICIENCIES
Session Time: Saturday, August 24, 13:20 -15:00
490
P5.22.01 - Identification of B-cell defects using age-defined reference ranges for in-vivo and in-vitro B-cell differentiation
Daan J. aan de Kerk, M.H. Jansen, I.J.M. ten Berge, E.M.M. van Leeuwen, T.W. Kuijpers;
Amsterdam, Netherlands
491
P5.22.02 - Autoimmune lymphoproliferative syndrome in a patient with homozygous mutation associated
to normal Fas expression
Nourhen Agrebi, I. Ben Mustapha, M. Medhaffar, M. Ben Ali, B. Larguèche, R. Barbouche;
Tunis, Tunisia
492
P5.22.03 - Evaluation of CD4+CD25+FOXP3+ regulatory T cells function in patients with common variable immunodeficiency
Nargess Arandi, A. Mirshafiey, M. Jeddi-Tehrani, H. Abolhassani, B. Sadeghi, M. Shaghaghi, A. Aghamohammadi;
Tehran, Iran, Islamic Republic of
493
P5.22.04 - AK2 deficiency in zebrafish recapitulates human reticular dysgenesis
A. Rissone, J. Jagadeesh, K. Bishop, T. Blake, R. Sood, Fabio Candotti;
Bethesda, United States
143
Posters - August 24
494
P5.22.05 - Monoclonal T proliferation associated with a diffuse and invalidant Sezary-like skin-infiltration in a patient
with Hyper-IgM syndrome
Speranza Antonia Di Maggio, A. Parolo, M. Gazzola, N. Compagno, V. Ferri, R. Scarpa, F. Cinetto, M. Putti, M. Alaibac, C. Agostini;
Padova, Italy
495
P5.22.06 - Investigation of ITGB2 gene in 9 Iranian patients with LAD-1 with two new mutations
Behnaz Esmaeili, M. Ghadami, M. Fazlollahi, M. Badalzadeh, Z. Alizadeh, L. Atarod, Z. Chavoshzadeh, S. Niroomanesh, Z. Moradi,
Z. Pourpak;
Tehran, Iran, Islamic Republic of
496
P5.22.07 - Adenosine deaminase deficient severe combined immunodeficiency: evidence from three case reports
Ferah Genel, E. Özbek, S. Keskin Gözmen, N. Gülez, O. Tascı, M. Hershfield;
Izmir, Turkey
497
P5.22.08 - Plasmablasts in peripheral blood after antigen challenge serve as a diagnostic marker for assessing response to
vaccination in CVID patients
Ewelina Grywalska, J. Rolinski, A. Surdacka, A. Grafka;
Lublin, Poland
498
P5.22.09 - Clinical features and immunological immunophenotyping in Hyper IgE syndrome patients
Lucrezia Guadrini, M. Giacomelli, D. Moratto, S. Negri, A. Prandini, R. Kumar, O. Scomodon, A. Plebani, R. Badolato;
Brescia, Italy
499
P5.22.10 - Long survival of a patient with IPEX syndrome (Immunodysregulation, Polyendocrinopathy, Enteropathy, X-linked)
C. Felice, A. Papa, R. Bacchetta, A. Armuzzi, M. Marzo, G. Andrisani, D. Pugliese, I. De Vitis, G. Rapaccini, Luisa Guidi;
Rome, Italy
500
P5.22.11 - Clinical features and immunological abnormalities of GATA2 deficiency in Japan
Kenichi Honma, K. Imai, T. Kato, C. Kamae, S. Nonoyama;
Tokorozawa, Japan
501
P5.22.12 - GATA 2 transcription factor deficiency predisposing to severe disseminated Coccidioidomycosis
Tasnim F. Imran, C. Chongwei;
Newark, United States
502
P5.22.13 - Common variable immunodeficiency classification by quantifying T-cell receptor and immunoglobulin κ-deleting
recombination excision circles
Chikako Kamae, N. Nakagawa, H. Sato, K. Honma, N. Mitsuiki, O. Ohara, H. Kanegane, T. Morio, K. Imai, S. Nonoyama;
Tokorozawa, Japan
503
P5.22.14 - Candida antibiotic resistance in Primary Immunodeficiency Disease
Samineh Kamali Sabzevari, Z. Pourpak, S. Roodbar Mohammadi, N. Fakhr Mousavi;
Tehran, Iran, Islamic Republic of
504
P5.22.15 - Subgroup of Common Variable Immunodeficiency patients with distinct clinical and biological features revealed
by B-cell immunophenotyping
Veronika Kanderova, E. Fronkova, J. Stuchly, M. Vlkova, I. Hermanova, L. Krol, O. Hrusak, A. Sediva, J. Litzman, T. Kalina;
Prague, Czech Republic
505
P5.22.16 - Hax-1 deficiency in Turkish children
Sara Sebnem Kilic, O. Gozukmez, D. Hafizoglu, C.Y. Aydogmus, F. Cipe, T. Yakut;
Bursa, Turkey
506
P5.22.17 - Investigation on frequency of mutation in the gene segments of immunoglobulin in CD40 knockout mice
Yuka Kodera, M. Matsushima, H. Ogiso, N. Ogasawara, K. Takemura, H. Nose, T. Yamaguchi, M. Shiga, T. Kawabe;
Nagoya, Japan
507
P5.22.18 - Frequency of lymphomas in a cohort of Common Variable Immunodeficiency (CVID) patients
B.C. Sini, Cristina M. Kokron, D. Levy, J. Pereira, A.K.B.B. Marinho, A. Cohon, J. Kalil, S. Bydlowski, M.T. Barros;
São Paulo, Brazil
508
P5.22.19 - Genetic analysis of the TNFRSF13B gene in a numerous Italian CVID population
Vassilios Lougaris, M. Vitali, M. Baronio, G. Tampella, A. Bergbreiter, U. Salzer, A. Soresina, R. Badolato, A. Plebani;
Brescia, Italy
509
P5.22.20 - Hypomorphic mutation in RAG2 gene affects dendritic cell distribution and migration
Virginia Maina, V. Marrella, S. Mantero, B. Cassani, E. Fontana, A. Anselmo, A. Del Prete, S. Sozzani, L. Poliani, A. Villa;
Milan, Italy
510
P5.22.21 - 8 patients of ataxia-telangiectasia in Azerbaijan
Vafa R. Mammadova;
Baku, Azerbaijan
511
P5.22.22 - Good’s syndrome: First case report in Algeria
Nesrine Messaoudani, R. Djidjik, L. Baough, A. Nekhla, F. Benserai, M. Boubrit, F. Asselah, N. Zidouni, M. Ghaffor;
Algiers, Algeria
512
P5.22.23 - Influence of genetic alterations in the WASP gene on the maturation of the B cell compartment
D. Moratto, Gaetana Lanzi, L. Gazzurelli, C. Mazza, L.D. Notarangelo, S. Giliani;
Brescia, Italy
513
P5.22.24 - A normal T cell receptor beta CDR3 length distribution in patients with APECED
Heikki J. Niemi, T. Koivula, S.M. Laakso, P. Arstila, A. Tuulasvaara;
Helsinki, Finland
144
Posters - August 24
514
P5.22.25 - Clinical and laboratory evaluation of patients with common variable immunodeficiency before and after
immunization with polysaccharide and protein antigens
Ana K.B. Oliveira, M. Pedreschi, A. Cohon, G.S. Brito, L.M. Fonseca, J. Kalil, M.T. Barros, C.M. Kokron;
São Paulo, Brazil
515
P5.22.26 - Skin sarcoid-like lesions in CVID with poor outcome
Roberto Paganelli, M.C. Turi, M. D’Urbano, E. Celletti;
Chieti scalo, Italy
516
P5.22.27 - Severe combined deficiency of innate and acquired immunity caused by an IKBKB mutation
Ulrich Pannicke, B. Baumann, S. Fuchs, P. Henneke, A. Rensing-Ehl, H. Schrezenmeier, T. Wirth, S. Ehl, M. Schroeder, K. Schwarz;
Ulm, Germany
517
P5.22.28 - Reduced NK cell activity and abnormal expression of CCR7 and CXCR1 by NK cells analysis in patients with
DOCK8 deficiency
Silvia Parolini, G. Tabellini, S. Caracciolo, O. Patrizi, M. Benassi, S. Negri, M. Giacomelli, V. Lougaris, A. Plebani, R. Badolato;
Brescia, Italy
518
P5.22.29 - Establishment of newborn screening for SCID / severe T lymphocytopenia in São Paulo
Marilia Pyles Patto Kanegae, A. Miyashiro Nunes dos Santos, B. Tavares Costa Carvalho, I. Rugue Genov, A.L. Acquesta;
Sao Paulo, Brazil
519
P5.22.30 - Targeted detection of chronic immunodeficiencies by flow cytometry
Ulrich Sack, S. Borte, M. Borte, F. Kahlenberg, A. Boldt;
Leipzig, Germany
520
P5.22.31 - A New Mutation associated to Bruton Amammaglobulinemia
F.R. Mora, R. de la Varga, E. Garcia Moreno, C. Rodriguez, Almudena Sampalo;
Cadiz, Spain
521
P5.22.32 - Clinical and Genetic heterogeneity of Chronic Mucocutaneus Candidiasis Disease in four Patients with
Heterozygous STAT1 mutations
Omar Scomodon, D. Vairo, M. Giacomelli, L. Tassone, G. Maggiore, A. Soresina, V. Lougaris, D. Dinwiddie, S. Kingsmore, R. Badolato;
Brescia, Italy
522
P5.22.33 - T regulatory cells and Helios expression in patients with diGeorge syndrome
Anna Sediva, K. Sismova, A. Klocperk, J. Grecova, A. Skalicka, R. Zachova;
Prague, Czech Republic
523
P5.22.34 - B cell dysregulation in autoimmune lymphoproliferative syndrome
Svetlana Sharapova, O. Pashchenko, A. Migas, I. Gyryanova, A. Nevmerzhitskaya, I.V. Kondratenko, M. Belevtsev;
Minsk region, Belarus
524
P5.22.35 - Prevalence of Tuberculosis among HIV/AIDS Patients In Obafemi Awolowo University Teaching Hospital
Complex (OAUTHC). ILE -IFE
Olarinde N. Olaniran
525
P5.22.36 - Antibody deficiency in Ataxia Telangiectasia is caused by disturbed B and T cell homeostasis and reduced immune
repertoire diversity
G.J.A. Driessen, H. IJspeert, C.M.R. Weemaes, Á. Haraldsson, A. Warris, N. Wulfraat, M. Taylor, J.J.M. Van Dongen, M. van Deuren,
Mirjam van der Burg;
Rotterdam, Netherlands
526
P5.22.37 - Expression of Bruton’s tyrosine kinase gene and endoplasmic reticulum stress markers in X-linked
agammaglobulinemia
V.D. Ramalho, M.A. Teocchi, B.M. Abramczuk, T.N. Mazzola, Maria M.S. Vilela;
Campinas, Brazil
527
P5.22.38 - Up-regulation of LY6E expression on monocytes attenuates innate immunity by down-regulating CD14
and is associated with HIV disease progression
Jianqing Xu, X. Zhang;
Jinshan, Shanghai, China
528
P5.22.39 - Lymphoid Intestitial Pneumonia in CVID -oligoclonal expansion of lymphocytes with preferential CMV-specific
immune response and lymphorpoliferative disease promotion. Successful rituximab therapy
Przemyslaw Zdziarski, A. Lange, D. Dlubek, K. Suchnicki;
Wroclaw-46, Poland
P6.01 IMMUNOMODULATION BY NUTRIENTS AND VITAMINS
Session Time: Saturday, August 24, 13:20 - 15:00
529
P6.01.01 - Vitamin D deficiency increases macrophage polarization and inflammatory infiltrates in epicardial adipose
tissue of atherosclerotic swine
Devendra K. Agrawal;
Omaha, United States
530
P6.01.02 - Impact of zinc supplementation on the production of IL-17 in perinatal stages
Ana E. Aguilar, M.T.C. Sanchez, B. Muñoz, R. Pastelin;
Mexico DF, Mexico
531
P6.01.03 - Uncaria tomentosa Willd. DC (Cat’s claw) immunostimulatory activity in splenic B lymphocytes
D.F. Zegarra Ruiz, Jose L. Aguilar;
Lima, Peru
145
Posters - August 24
532
P6.01.04 - Leucocytes and Oxidative Stress by Non-Thermal Plasma
Sander Bekeschus, J. Kolata, K. Masur, K. Weltmann, B.M. Bröker;
Greifswald, Germany
533
P6.01.05 - The sensitivity to different types of milk in patients with Ulcerative colitis
Irina Besu, A. Konic-Ristic, N. Jojic, D. Popovic, Z. Juranic;
Belgrade, Serbia
534
P6.01.06 - New therapeutic strategies using xCELLigence system in colon cancer
Lorelei I. Brasoveanu, D. Hotnog, I. Iancu, C. Hotnog, A. Botezatu, M. Bostan, M. Mihaila, G. Anton;
Bucharest, Romania
535
P6.01.07 - Beta-glucans Uptake by Human Dendritic Cells via a Variety of Endocytotic Mechanisms
Jiamin Cao, G.C.F. Chan;
Pokfulam, Hong Kong
536
P6.01.08 - Nourishment and its relation with immunitary response and oxidative stress
Edelis Catellanos;
La Habana, Cuba
537
P6.01.09 - Inflammatory pattern, vitamin D level and cognitive performance in adults and older adults
Hala Darwish, S.J. Khoury;
Beirut, Lebanon
538
P6.01.10 - Comparative study of the antiinflammatory effect of Inca Inchi oils (Plukenetia volubilis and Plukenetia
huayllabambana)
Silvia R. Dávila Paico, C. Pitot, D. Zegarra Ruiz, M.A. Cabello Napurí, F. Saldaña Morales, T. Ysmodes Nastasi, Y. Álvarez Valdivia,
C. Ocampo Acuña, I. Lozada Requena, J. Aguilar Olano;
Lima, Peru
539
P6.01.11 - Iron overload can suppress IL-23 expression from human monocyte-derived dendritic cells and subsequent
downstream Th17 expansion
C M.A. Dee, K.W. Cheung, J. Shen, G.C.F. Chan;
Pokfulam, Hong Kong
540
P6.01.12 - Antioxidant compounds suppress activity of diamine oxidase (DAO)
Johanna M. Gostner, K. Becker, F. Überall, D. Fuchs;
Innsbruck, Austria
541
P6.01.13 - Ayurvedic myrobalane extracts inhibit LPS-induced tryptophan breakdown in THP-1 cells
K. Becker, Johanna M. Gostner, A. Klein, S. Schröcksnadel, B. Magnus, M. Jenny, D. Fuchs, F. Überall;
Innsbruck, Austria
542
P6.01.14 - Resveratrol enhances TNF-α production of human monocytes upon TLR-stimulation
Guido Gualdoni, J. Kovarik, D. Doberer, F. Dose, P. Steinberger, M. Wolzt, G.J. Zlabinger;
Vienna, Austria
543
P6.01.15 - Inhibition of matrix metalloproteinase-9 activity in a leukemic cell line by Mentha spicata extract in vitro
Fatemeh Hajighasemi;
Tehran, Iran, Islamic Republic of
544
P6.01.16 - Labdane-type diterpene, constituent from myoga which are traditional Japanese food inhibit enzyme activity
and gene expression of indoleamine 2,3-dioxygenase 1
Shinjiro Imai, R. Yamamoto, Y. Yamamoto, M. Abe, Y. Ozawa, Y. Katayanagi, T. Nakayama, K. Saito;
Suruga-ku, Shizuoka, Japan
545
P6.01.17 - HemoHIM, a novel composition of medicinal herbs, restores the lasting imbalance of Th1- and Th2-related
immune response in gamma-irradiated mice and in aged mice
Sung-Kee Jo, H. Park, U. Jung;
Jeongeup-si, Korea, Republic of
546
P6.01.18 - Implications of the O-GlcNAc modification in the regulation of nuclear apoptosis in T cells
Bruno Johnson, J. Bernier;
Laval, Canada
547
P6.01.19 - Alliin diminished pro-inflammatory cytokines in supernatants of an in vitro model of adipose tissue
Rocio I. Lopez-Roa, S.M. Quintero-Fabian, T.M. Garcia-Iglesias, J.M. Viveros-Paredes, D. Ortuño-Sahagun;
Guadalajara, Mexico
548
P6.01.20 - The activity of autoreactive IgG antibodies may be blocked by human serum and breast milk immunoglobulins
Iliyan Manoylov, I. Djoumerska-Alexieva, J. Dimitrov, A. Tchrobanov;
Sofia, Bulgaria
549
P6.01.21 - Difference in reaction patterns of M1 and M2 macrophages induced by quercetin
Miyoko Matsushima, A. Oomura, K. Mori, N. Ogasawara, K. Takemura, H. Nose, T. Yamaguchi, Y. Kodera, M. Shiga, T. Kawabe;
Nagoya, Japan
550
P6.01.22 - Expression of cytokines that regulate immune responses in alpaca (Vicugna pacos) blood leukocytes stimulated
by clostridial antigens and retinoic acid
Juan More Bayona, A. Manchego, K. Chiok, R. Lázaro, N. Sandoval, H. Rivera, M. Ramírez;
Lima, Peru
551
P6.01.23 - Expression of humoral and cellular immune response cytokines in alpacas (Vicugna pacos) treated orally with a
combination of clostridial antigens and retinoic acid
Juan More Bayona, A. Manchego, K. Chiok, D. Pezo, N. Sandoval, H. Rivera, M. Ramírez;
Lima, Peru
146
Posters - August 24
552
P6.01.24 - Immune-modulatory properties of cinnamaldehyde are associated with the induction of apoptosis in immune cells
Anna Moskovskich, C. Gomez-Casado, A. Willensdorfer, J. Singer, H.C. Fuchs, F. Roth-Walter, E. Jensen-Jarolim;
Vienna, Austria
553
P6.01.25 - The effect of quercetin on the activated alveolar macrophages
Haruka Nose, M. Matsushima, A. Oomura, K. Mori, N. Ogasawara, K. Takemura, T. Yamaguchi, Y. Kodera, M. Shiga, T. Kawabe;
Nagoya, Japan
554
P6.01.26 - Cucumis sativus aqueous extract protects against different metabolic syndrome- associated pathologies
Gabriela Rosas, P. Nuñez, A. Arteaga, M. Martínez, C. Trejo, A. Zamilpa, J. Tortoriello, G. Arrelín, E. Jimenez, G. Fragoso;
Mexico, Mexico
555
P6.01.27 - Cytoprotective activity of Georgian Red Grapes Extract in mitogen-activated Jurkat cells
Tamara Sanikidze, G. Sharashenidze, L. Ratiani;
Tbilisi, Georgia
556
P6.01.28 - Chrysin regulates mast cell activation via HO-1-independent pathway
Marika Shiga, M. Matsushima, A. Teranishi, H. Nose, N. Ogasawara, K. Takemura, T. Yamaguchi, Y. Kodera, T. Kawabe;
Nagoya, Japan
557
P6.01.29 - Methanol extract of Origanum vulgare ameliorates autoimmune diabetes in mice
Ivana D. Stojanovic, M. Vujicic, I. Nikolic, V. Kontogianni, P. Charisiadis, A.G. Tzakos, S. Stosic-Grujicic;
Belgrade, Serbia
558
P6.01.30 - Evaluation of of crude extracts of sea cucumbers Holothuria lecospilota Genus in persion gulf effects on COX-2
and VEGF genes expression and PGE2, VEGF secretion levels in comparison with celecoxib on colorectal cancer cell line
Maryam Taghdiri, A. Khodadadi, M. Assarehzadegan, N. Adibpour;
Ahvaz, Iran, Islamic Republic of
559
P6.01.31 - In vitro immunomodulatory and cytoprotective effects of Origanum vulgare methanol extract
Milica Vujicic, I. Stojanovic, I. Nikolic, V. Kontogianni, P. Charisiadis, A.G. Tzakos, S. Stosic-Grujicic;
Belgrade, Serbia
P6.02 METABOLISM AND IMMUNITY INTERFACES
Session Time: Saturday, August 24, 13:20 - 15:00
560
P6.02.01 - Evaluation of the relationship between obesity and pro- and anti-inflammatory cytokines in postmenopausal
breast cancer patients
Rodrigo Andrade, H.C. do Nascimento, A.B. Santana, M.S.C. Gurgel, F.L.P. Costa, S. de Barros-Mazon;
Campinas, Brazil
561
P6.02.02 - Arginine depletion during ocular autoimmune responses: in vitro study on bovine explants
Houda Belguendouz, K. Lahmar-Belguendouz, L.M. Ahmedi, D. Messaoudene, Z. Djeraba, O.S. Lahlou-Boukoffa, C. Touil-Boukoffa;
Algiers, Algeria
562
P6.02.03 - Respiratory complex III (CIII) or Adenin-Nucloeotide Transporter (ANT) inhibition diminishes human monocyte
inflammatory capacity
Esteban D. Cerezo, L.A. Flores-Mejía, F.J. Sánchez-García, C.R. López-Macías, A. Isibasi, L.A. Arriaga-Pizano;
Mexico City, Mexico
563
P6.02.04 - The human intermediate monocyte subset can be further subdivided on the basis of HLA-DR expression
revealing a distinct abnormality in obesity and diabetes
M. C. Dennedy, E. Connaughton, S. Slevin, S.A. Hanley, T. O’Brien, R. Ceredig, M.D. Griffin;
Galway, Ireland
564
P6.02.05 - Clinical-immunological assessment of therapy effect of the neuro-sensory-motor integration program of reflex
patterns in airway chronic inflammatory diseases
S.K. Masgutova, N.K. Akhmatova, Olga V. Lebedinskaya;
Perm, Russian Federation
565
P6.02.06 - Diet enriched with small carbohydrate and saturated fat is able to alter immunological parameters in C57BL/6
mice
M.C.G. Miranda, J.L. Goncalves, T.G. Moreira, L.G. Teixeira, A.L. Souza, D.C. Cara, Tatiani U. Maioli, A.C. Faria;
Belo Horizonte, Brazil
566
P6.02.07 - Macrophages, but not adipocytes, express TNFa in diet induced visceral obesity
Marcia F. McInerney, L.A. Ebke, B. Slotterbeck, A.L. Nestor-Kalinoski, A.G. Al Dieri, S. Ghosh, S.M. Najjar, H. von Grafenstein;
Toledo, United States
567
P6.02.08 - Activation markers show greater expression on adipose tissue resident T-lymphocytes with increased adiposity
R. Travers, Alexandre C. Motta, J. Betts, D. Thompson;
Vlaardingen, Netherlands
568
P6.02.09 - Galectin-3 deficiency accelerates high-fat diet induced obesity and diabetes by amplifying metaflammation
Nada Pejnovic, J. Pantic, I. Jovanovic, G. Radosavljevic, M. Milovanovic, I. Nikolic, N. Zdravkovic, A. Djukic, N. Arsenijevic, M. Lukic;
Kragujevac, Serbia
569
P6.02.10 - P2X7 receptor expression and potential role in T cells in Type 1 Diabetes
Lisa Perruzza, F. Grassi;
Bellinzona, Switzerland
570
P6.02.11 - Insulin resistant obese individuals have increased frequency of CD14++CD16+ monocytes, what is modulated
by a bout of aerobic exercise
Etel Rocha-Vieira, M. Matos, T. Duarte, V. Ottone, K. Costa, G. Brito-Melo, F. Amorim;
Diamantina, Brazil
147
Posters - August 24
571
P6.02.12 - The regulatory role of amino acids in the immune response
Nataliya Salyha;
Lviv, Ukraine
572
P6.02.13 - The peptide hormone Insulin-like growth factor-1 affects the immune system during physiological and
pathological inflammatory responses
Susanne Sattler, B. Johannesson, J. Tonkin, E. Gallego-Colon, D. Bilbao, E. Semenova, N. Rosenthal;
London, United Kingdom
573
P6.02.14 - Unsuspected relationship between Ferritin Heavy Chain and NK cells tumor susceptibility
Rosa Sottile, F. Santoro, C.M. Faniello, C. Garofalo, R. Tallerico, F.S. Costanzo, E. Carbone;
Catanzaro, Italy
574
P6.02.15 - Modulation of lipid metabolism and colon cancer cell growth by Cyclosporin A
Miriam B.F. Werneck, M.C. Augustin, J.P.B. Viola, P.T. Bozza;
Rio de Janeiro, Brazil
575
P6.02.16 - Enhanced glycogen synthase kinase 3beta phosphorylation modulates leukocyte Toll-like receptor-mediated
cytokine secretion in obesity
Chia-Liang Yen, C. Chang, C. Wu, C. Shieh;
Tainan, Taiwan
P6.06 CANCER IMMUNOTHERAPY AND ANTI-TUMOR VACCINES
Session Time: Saturday, August 24, 13:20 - 15:00
576
P6.06.001 - Inhibitory effects of single chain fragment variable (scFv) antibodies against prostate stem cell antigen (PSCA)
on prostate and pancreatic cancer cell lines
Soghra Abdi, F. Nejatollahi;
Ilam, Iran, Islamic Republic of
577
P6.06.003 - GMP-production of an allogenic DC-based cancer vaccine (COMBIG-DC) for treatment of patients with
metastatic renal cancer using the ELUTRA Platform
Lars Adamson, R. Kiessling, B. Andersson, B. Näsman-Glaser, A. Karlsson-Parra;
Stockholm, Sweden
578
P6.06.004 - Breast cancer immunopathology to immunotherapy in Northern Emirates of the United Arab Emirates
Mohamad Alhomssi, A. Mohamad, H. Hamdy;
Sharjah, United Arab Emirates
579
P6.06.005 - Generation and characterization of a new chimeric antibody against Her2
Mohammad M. Amiri, M. Jeddi-Tehrani, M. Bahadori, M. Hojjat-Farsangi, J. Khoshnoodi, H. Rabbani, F. Shokri;
Tehran, Iran, Islamic Republic of
580
P6.06.006 - Annexin A2 is a Glioma Damage-Associated Molecular Pattern Enriched in Physiologic Oxygen
Brian M. Andersen, M.R. Olin, C.E. Seiler, X. Junzhe, A.L. Epstein, W. Chen, B.R. Blazar, J.R. Ohlfest;
Minneapolis, United States
581
P6.06.007 - MHC I multimer assay: Optimized double staining for improved sensitivity in detection of low affine
CD8+ antigen-specific T cells by flow cytometry
Stig Henrik Andersen, K. Jacobsen, L. Brix, H. Pedersen;
Copenhagen, Denmark
582
P6.06.008 - Increased efficacy of dendritic cells by protein components compared to total extract of Listeria monocytogenes
in experimental tumor Immunotherapy
Samaneh Arab, M. Motamedi, J. Hadjati;
Tehran, Iran, Islamic Republic of
583
P6.06.009 - Green tea polyphenols modulate certain indices of nonspecific anticancer resistance
Anna B. Artamonova, S.P. Zaletok, O.V. Karnaushenko, A.V. Verbinenko;
Kyiv, Ukraine
584
P6.06.010 - Polysaccharides of the Lentinus edodes modulate certain indices of specific anticancer resistance
Anna B. Artamonova, V.O. Shlyakhovenko;
Kyiv, Ukraine
585
P6.06.011 - Anti-Metastatic Effect of Anti-HER2 scFv Antibodies on Breast Cancer Cells
Mahdi Asgharpour, F. Nejatollahi;
Shiraz, Iran, Islamic Republic of
586
P6.06.012 - ImmTACs: bi-specific TCR-anti-CD3 fusions for potent re-directed killing of cancer cells
Rebecca Ashfield, G. Bossi, D. Baker, J. Harper, J. Dukes, N. Liddy, Y. McGrath, A. Vuidepot, N. Hassan, B. Jakobsen;
Abingdon, Oxfordshire, United Kingdom
587
P6.06.013 - Oroxylin A affects frequency and function of myeloid-derived suppressor cells in experimental model of cancer
Mahboubeh Ashourpour, A. Namdar, J. Hadjati;
Tehran, Iran, Islamic Republic of
588
P6.06.014 - T cell tolerance as function of tumor progression
Meir Azulay, E. Tzehoval, E. Vadai, L. Eisenbach;
Rehovot, Israel
589
P6.06.015 - TLR3/BATF3 axis in CD8α+DC induces anti-tumor CTLs by dsRNA
Masahiro Azuma, M. Matsumoto, T. Seya;
Sapporo, Japan
148
Posters - August 24
590
P6.06.016 - Anti-tumor effects of heat shock proteins, Bacillus Calmette-Guérin, angiogenesis inhibitor, Bifidobacterium
and Immuno-Modulator Drug on fibrosarcoma in mice
Behzad Baradaran, J. Majidi, T. Kazemi, L. Aghebati, M. Orangi;
Tabriz, Iran, Islamic Republic of
591
P6.06.017 - Maternal immunization: transfer of a protective anti-tumor immunity from mothers to the offspring; a first
evidence
Giuseppina Barutello, M. Arigoni, C. Curcio, M. Spadaro, R. Clynes, R. Trovato, E. Bolli, F. Riccardo, F. Ria, F. Cavallo;
Torino, Italy
592
P6.06.018 - The peripheral blood compartment of patients with Diffuse Large B Cell Lymphoma (DLBCL) at diagnosis is
characterized by distinct phenotypic and functional Immunological alterations
Simone Battella, S. Pelliccia, R. La Scaleia, A. Di Napoli, A. Porzia, L. Ruco, F. Mainiero, A. Santoni, M.C. Cox, G. Palmieri;
Rome, Italy
593
P6.06.019 - Adenosine receptor blockade potently suppresses the metastasis of CD73+ tumours
Paul A. Beavis, U. Divisekera, C. Paget, M.T. Chow, L.B. John, J. Stagg, M.J. Smyth, P.K. Darcy;
Melbourne, Australia
594
P6.06.020 - Development of a DC-based therapeutic vaccine for AML patients: characterization of GMP-grade TLR-agonist
matured 3-day DCs expressing the leukemia-associated antigens WT1 and PRAME
Barbara Beck, C. Geiger, I. Bigalke, F.S. Lichtenegger, G. Kvalheim, M. Subklewe, D.J. Schendel;
Munich, Germany
595
P6.06.021 - Development of new therapeutic antibodies formats directed against the folate receptor alpha
Davide Bernareggi, E. Luison, A. Satta, B. Frigerio, M. Colombo, S. Canevari, M. Figini;
Milan, Italy
596
P6.06.022 - Toxoplasma gondii protein fractions for the generation of dendritic cell based cancer vaccine
Roobina Boghozian, A. Saei, R. Mirzaei, J. Hajati;
Tehran, Iran, Islamic Republic of
597
P6.06.023 - Comparison of DNA-based vaccine and non-pathogenic live vaccine strategies using the mini-chaperones for
the prevention of HPV16 E7-overexpressing cancers
Azam Bolhassani, S. Hosseinzadeh, A. Daemi;
Tehran, Iran, Islamic Republic of
598
P6.06.024 - Antitumor potential of novel betulin derivative on human A375 melanoma cells
Mirna Bulatovic, M. Mojic, G. Kaluderovic , D. Miljkovic , S. Stosic -Grujicic , R. Paschke, S. Mijatovic , D. Maksimovic -Ivanic ;
Belgrade, Serbia
599
P6.06.025 - Early growth response gene 2 acts as an intrinsic negative regulator of DC immunogenicity
M.A. Miah, Se Eun E. Byeon, Y.S. Bae;
Suwon, Gyeonggi-do, Korea, Republic of
600
P6.06.026 - ENO1-DNA vaccine significantly delays pancreatic tumor progression by eliciting complement-dependent cytotoxicity
Paola Cappello, S. Rolla, R. Curto, E. Tonoli, M. Principe, H. Carnevale, M. Giovarelli, F. Novelli;
Torino, Italy
601
P6.06.027 - Enrichment of KIR+CD57+ highly cytotoxic NK cells in sentinel lymph nodes of melanoma patients
Ennio Carbone, T. Hassan Ali, S. Pisanti, E. Ciaglia, R. Mortarini, A. Anichini, M. Santinami, E. Gulletta, C. Ietto, M. Galgani;
Catanzaro, Italy
602
P6.06.028 - Multiple Myeloma cells in Vk*MYC mice are highly susceptible to WT1 and MAGE-A specific cytotoxic
T lymphocytes
Elena Cattaneo, A. Calcinotto, M. Grioni, A. Gasparri, M. Bianco, S. Bertilaccio, M. Chesi, L. Bergsagel, A. Corti, M. Bellone;
Milan, Italy
603
P6.06.029 - Vaccination with human CSPG4 DNA induces an anti-tumor antibody response and prolongs survival in dogs
with oral malignant melanoma
F. Riccardo, S. Lorda Mayayo, S. Prestigio, S. Iussich, G. La Rosa, R. De Maria, S. Ferrone, P. Buracco, Federica Cavallo;
Torino, Italy
604
P6.06.030 - Correlation between the high expression of cancer testis antigens and the prognosis in patients with
esophageal carcinoma in China
Xin-Feng Chen, J. Liu, M. Wang, Y. Zhang;
Zheng Zhou, China
605
P6.06.031 - CD38 immunotherapy: killing two birds with one stone
Antonella Chillemi, V. Quarona, G. Zaccarello, M. Ferracin, C. Ghimenti, A. Zito, M. Massaia, A.L. Horenstein, F. Malavasi;
Torino, Italy
606
P6.06.032 - Combination immunotherapy with tumor-specific CD4+ and CD8+ T cells decreases CD8+ T cell exhaustion and
augments therapeutic efficacy
Sarah E. Church, S.M. Jensen, B.A. Fox;
Portland, United States
607
P6.06.033 - A new pathway of tumor antigen loading of human dendritic cells via intercellular communication
Mariarosa Ciranna, L. Morelli, C. Pozzi, G. Penna, M. Rescigno;
Milan, Italy
608
P6.06.034 - A phase Ib clinical trial of cisplatin and pemetrexed in combination with the CD40 activating antibody CP-870,893
A. McDonnell, Alistair Cook, B.W.S. Robinson, R.A. Lake, J. Creaney, A. Hasani, M. Millward, A.K. Nowak;
Perth, Australia
149
Posters - August 24
609
P6.06.035 - Optimising regulatory T cell (Treg) depletion in combination with chemotherapy for enhanced anti-tumour
immunity
Alistair Cook, B. Robinson, A. McDonnell, M. Millward, R.A. Lake, A.K. Nowak;
Perth, Australia
610
P6.06.036 - Radiation therapy plus IL-2 in patients with metastatic melanoma is associated with release of danger associated
molecular patterns when compared to IL-2 alone but not an increase in circulating inflammatory cytokines
Marka R. Crittenden, M. Gough, B. Fox, S. Seung, B. Cottam, J. Walker, W. Urba, B. Curti;
Portland, United States
611
P6.06.037 - RIL-21 combined with CD4-T cell depletion reprograms CD4+ T cells from an immune regulatory to an
anti-tumor phenotype in syngeneic neuroblastoma
Michela Croce, A. Brizzolara, V. Rigo, A. Orengo, B. Carlini, M. Corrias, S. Ferrini;
Genoa, Italy
612
P6.06.038 - Pre-clinical development of an agonistic CD40 antibody (ADC-1013) for local immunotherapy of cancer
Eva Dahlén, C. Furebring, S. Broos, T. Berggård, P. Norlén, M. Lindstedt, T. Tötterman, S. Mangsbo, P. Ellmark;
Lund, Sweden
613
P6.06.039 - Th1/Th2/Th17 profile and T cell phenotype of an in vitro antigen presentation system in response to DC
functionality, IL-2 and IGF-1 presence
Anne-Lise de Lastic, M. Rodi, A. Mouzaki;
Patras, Greece
614
P6.06.040 - The predictive role of αβ-double negative T cells in clinical outcome of patients with lymphoma: preliminary
data
Giacoma De Tullio, C. Minoia, S. Serratì, F. Merchionne, G. Loseto, A. La Pietra, A. Rana, A. Iacobazzi, P. Iacopino, A. Guarini;
Bari, Italy
615
P6.06.041 - Deciphering adaptive anti-tumor immunity induced by anti-CD20 mAb treatment
Claire Deligne, A. Metidji, J. Teillaud;
Paris, France
616
P6.06.042 - The tumor microenvironment can vary with anatomical site to affect responses to therapy
Christel Devaud, J.A. Westwood, L.B. John, J.K. Flynn, S. Paquet-Fifield, M.J. Smyth, P.K. Darcy, M.H. Kershaw;
East Melbourne (VIC), Australia
617
P6.06.043 - Antitumor activity of PEGylated Fab-fragments of GD2-specific antibody
Igor I. Doronin, I. Kholodenko, I. Molotkovskaya, R. Kholodenko;
Moscow, Russian Federation
618
P6.06.045 - Chimeric protein of IL-2 linked to light chain of anti-IL-2 mAb S4B6 that structurally mimics IL-2/S4B6
immunocomplexes: design and production
Barbora Dvorakova, J. Tomala, J. Kovarova, M. Kabesova, P. Votavova, H. Chmelova, B. Rihova, M. Kovar;
Prague, Czech Republic
619
P6.06.046 - Enhanced efficacy of a cancer vaccine by blocking TGF-β-dependent induction of regulatory T cells with a
retinoic acid receptor-α antagonist
Lydia Dyck, K.C. Galvin, K.H.G. Mills;
Dublin, Ireland
620
P6.06.047 - Lymphocyte imprinting with melanoma antigens acquired by trogocytosis facilitates identification of
tumor-reactive T cells
Galit Eisenberg, R. Uzana, A. Pato, S. Frankenburg, S. Merims, E. Yefenof, S. Ferrone, T. Peretz, M. Lotem, A. Machlenkin;
Jerusalem, Israel
621
P6.06.048 - Inhibition of intercellular communication between prostate cancer cells by anti-STEAP-1 single chain antibody
Alireza Esmaili, F. Nejatollahi;
Shiraz, Iran, Islamic Republic of
622
P6.06.049 - Soluble MICA serum levels as predictive biomarkers of anti-CTLA-4 melanoma immunotherapy
Joana Felix, R. Porcher, C. Pages, I. Sidina, V. Kheav, G. Maki, M. Viguier, A. Toubert, C. Lebbe, H. Moins-Teisserenc;
Paris, France
623
P6.06.050 - Bispecific single-chain diabodies for T cell retargeting to solid tumors
Sina Fellermeier, R.E. Kontermann;
Stuttgart, Germany
624
P6.06.051 - Natural Killer adoptive cell transfer targeting bladder cancer stem cells: preliminary results for fine-tuning
strategy
Margarida Ferreira-Teixeira, B. Parada, F. Reis, C. Gomes, P. Rodrigues-Santos;
Coimbra, Portugal
625
P6.06.052 - A Dendritic Cell (DC) microRNA signature predicts clinical outcome in Melanoma Patients treated with
DC vaccine
Laura Fiammenghi, E. Bandini, F. Fanini, M. Petrini, E. Pancisi, A.M. Granato, V. Ancarani, L. Ridolfi, M. Guidoboni, M. Fabbri;
Meldola, Italy
626
P6.06.053 - Anti folate receptor Ab conjugated iron-oxide nanoparticles for tumor localization in an ovarian cancer
models
Mariangela Figini;
Milan, Italy
627
P6.06.054 - Combining prime-boost anti-tumour vaccination with debulking surgery for the treatment of solid tumours
Scott A. Fisher, A. Cleaver, A. Khong, T. Connor, B. Wylie, D. Lakhiani, C. Boylen, B.W.S. Robinson, R.A. Lake;
Perth, Australia
150
Posters - August 24
628
P6.06.055 - Anti-PSMA scFv as theranostic tool for prostate cancer
Barbara Frigerio, E. Luison, A. Satta, D. Bernareggi, F. Caroli, E. Bombardieri, G. Fracasso, S. Canevari, M. Figini;
Milan, Italy
629
P6.06.056 - Generation of EBV/CMV bi-specific T cells using retroviral T cell receptor (TCR) gene transduction for adoptive
immunotherapy
Ahmed Z. Gad, X. Liang, A. Moosmann;
Munich, Germany
630
P6.06.057 - Sub-lethal irradiation of human colorectal carcinoma cells imparts enhanced and sustained expression of
important modulators of effector CTL activity
Charlie Garnett-Benson, A. Kumari;
Atlanta, United States
631
P6.06.058 - Differential regulation of B-cell proliferation by IL21 in different subsets of chronic lymphocytic leukemia
Ghasem Ghalamfarsa, F. Jadidi-Niaragh, M. Hojjat-Farsangi, M. Yousefi, S. Razavi, A. Saboor-Yaraghi, H. Rabbani, M. Jeddi-Tehrani,
F. Shokri;
Tehran, Iran, Islamic Republic of
632
P6.06.059 - Lysis-on-chip of single cells after programmed interaction with cytotoxic T-lymphocytes (CTLs) or natural killer
(NK) cells on a dielectrophoresis (DEP) based array
M. Abonnenc, M. Borgatti, F. Destro, N. Manaresi, G. Medoro, E. Lo Monaco, Patrizio Giacomini, R. Guerrieri, R. Gambari;
Rome, Italy
633
P6.06.060 - Anticancerogenic and immunotropic properties of GA-40 preparation
Alexsidze Giorgi;
Tbilisi, Georgia
634
P6.06.061 - Chronic exhaustion of tumor-specific CD4+ T cells leads to recurrence of melanoma
Stephen R. Goding, K.A. Wilson, K.M. Harris, P.A. Antony;
Baltimore, United States
635
P6.06.062 - Effect of polychemotherapy on leukocytes under acute lymphoblast leukosis in children
O.V. Lebedinskaya, N.B. Merzlova, Anatoliy P. Godovalov, I.A. Baranova, A.V. Proskuryakov;
Perm, Russian Federation
636
P6.06.063 - Identification and validation of hypoxia-specific tumor associated antigens in prostate cancer
T. Ma, A. Elkhattouti, S. Vuk-Pavlovi , Christian R. Gomez;
Jackson, United States
637
P6.06.064 - A melanoma cell lysate induces CCR7 expression on human dendritic cells and its in vivo migration to draining
lymph nodes
Fermín González;
Santiago, Chile
638
P6.06.065 - Low-dose conventional chemotherapeutics synergizes with dendritic cell - based immunotherapy in antitumor
activity
Alexander I. Gorbach, N.M. Khranovska, V.K. Pozur, O.V. Skachkova, N.M. Svergun, R.I. Sydor, V.V. Nikulina;
Kyiv, Ukraine
639
P6.06.066 - Targeting effector CD8 T cells to the tumor using high dose radiation therapy in mice
Michael Gough, K. Young, B. Cottam, T. Savage, P. Newell, K. Bahjat, M. Crittenden;
Portland, United States
640
P6.06.067 - Vaccination with autologous glioma lysate induces tumor-reactive IgG antibody response and increases
survival in dogs with glioma
Michelle R. Goulart, B.M. Andersen, C.E. Seiler, M.A. Hunt, M.G. O’Sullivan, C. Johnson, Z. Zhang, J.R. Ohlfest, G.E. Pluhar;
St. Paul, United States
641
P6.06.068 - “First AID” for T cell adoptive transfer: TCR affinity maturation by somatic hypermutation
Yosi M. Gozlan, E. Tzehoval, L. Eisenbach;
Rehovot, Israel
642
P6.06.069 - HPV-derived T-helper epitopes for therapeutic HPV vaccine design
Agnieszka K. Grabowska, S. Hoppe, R. Blatnik, A.B. Riemer;
Heidelberg, Germany
643
P6.06.070 - CpG-activated pDCs contribute as APCs in the generation of Th17 cells that control tumor growth
Leslie Guery, J. Dubrot, C. Lippens, D. Brighouse, M. Irla, W. Reith, J. Waldburger, S. Hugues;
Geneva, Switzerland
644
P6.06.071 - Role of B cells in anti-tumour immunity
Thomas V. Guy, A.J. Buckley, J. Holst, R. Brink, B. Fazekas de St Groth, E. Shklovskaya;
Sydney, Australia
645
P6.06.072 - Comparison of monocyte derived dendritic cells versus leukemic blasts derived dendritic cells for
immunotherapy of AML
Jamshid Hadjati, F. Masoumi, M. Nourizadeh, R. Mirzaei;
Tehran, Iran, Islamic Republic of
646
P6.06.073 - IMCgp100: a novel bi-specific biologic for the treatment of malignant melanoma
Namir J. Hassan, G. Bossi, K. Adams, J. Harper, D. Baker, N. Steven, J. Evans, M. Middleton, Y. McGrath, B. Jakobsen;
Abingdon, United Kingdom
151
Posters - August 24
647
P6.06.074 - RNActive - A novel mRNA-based vaccination technology induces strong T- and B-cell responses in phase I/IIa
trials in non-small-cell lung cancer and prostate carcinoma patients
Regina Heidenreich, M. Sebastian, B. Scheel, S.D. Koch, H. Kübler, A. Stenzl, A. Zippelius, W. Schultze-Seemann, A. Knuth,
K. Kallen;
Tübingen, Germany
648
P6.06.075 - Limitation of systemic exposure to transgenic interleukin-12 upon local treatment with armed oncolytic
adenoviruses
M. Bunuales, J. Quetglas, E. Garcia-Aragoncillo, R. Casado, S. Bortolanza, J. Prieto, Ruben Hernandez-Alcoceba;
Pamplona, Spain
649
P6.06.076 - Isolation of T cell receptors specific for validated cancer epitopes for cancer immunotherapy
Linda Hibbert, L.U. Wiegand, S. Paston, D.E. Baker, J.D. Dukes, J.V. Harper, G. Bossi, F.H. Grand, T.M. Mahon, B.K. Jakobsen;
Abingdon, United Kingdom
650
P6.06.077 - Dichloromethane fractions of Scrophularia oxysepala induce apoptosis in MCF-7 human breast cancer cells
Behnaz Sadat Hosseini, B. Baradaran, J. Majidiz Zolbanin, A. Pasdaran, T. Kazemi, M. Orangi, L. Mohamadnejad;
Tabriz, Iran, Islamic Republic of
651
P6.06.078 - Targeted multivalent scTRAIL fusion proteins for tumor therapy
Meike Hutt, M. Siegemund, O. Seifert, K. Pfizenmaier, R.E. Kontermann;
Stuttgart, Germany
652
P6.06.079 - Long-term CTL induction and therapeutic tumor suppression by antigen- and adjuvant-carrying polymer
nanoparticles
Petr Ilyinskii, C. Roy, C. O’Neil, D. Altreuter, K. Kishimoto;
Watertown, United States
653
P6.06.080 - Antitumor activity of Her2 liposomes
M. Yazdani, A. Badiee, S. Jalali, Mahmoud R. Jaafari;
Mashhad, Iran, Islamic Republic of
654
P6.06.081 - Antitumor activity of HER2-MPL Liposomes
S. Shariat, S. Mortazavi, A. Badiee, S. Jalali, Mahmoud R. Jaafari;
Mashhad, Iran, Islamic Republic of
655
P6.06.082 - Antitumor activity of Her2/CpG liposomes
M. Mansourian, A. Badiee, S. Jalali, Mahmoud R. Jaafari;
Mashhad, Iran, Islamic Republic of
656
P6.06.083 - Apoptosis induction in head and neck squamous cell line with combined drug therapy
N. Cruz de Victo, D. Pinto Junior, G. Amarante-Mendes, Jacqueline Jacysyn;
São Paulo, Brazil
657
P6.06.084 - Murine CTL response using rHER2/neu-petide
S. Jalali, H. Ghaffari –Nazari, S. Tahaghoghi-ghorbani, Arash Jafari, M.R. Jaafari;
Mashhad, Iran, Islamic Republic of
658
P6.06.085 - Synergistic effect of combined local irradiation and dendritic cell vaccine in murine fibrosarcoma tumor
Arezoo Jamali, A. Amari, A. Pourgholaminejad, A. Saei, R. Boghozian, Z. Gheflati, N. Sepanlou, J. Hadjati;
Tehran, Iran, Islamic Republic of
659
P6.06.086 - Molecular diagnosis of human papilloma virus (HPV) infection in Tunisian women with various types of cervical
lesions
Mouna Jendoubi;
Tunis, Tunisia
660
P6.06.088 - Immunostimulatory properties and antitumor activity of short double-stranded RNA against hepatocarcinoma
G29 and melanoma B16
Tatyana O. Kabilova, L.V. Kovtonyuk, E.I. Ryabchikova, E.V. Zonov, N.A. Popova, V.P. Nikolin, M.A. Zenkova, V.V. Vlassov, E.L. Chernolovskaya;
Novosibirsk, Russian Federation
661
P6.06.089 - EXOLIGOS: a CpG oligonucleotide loaded exosome nanovesicle delivery platform suitable for effective
immune modulation
Tamer Kahraman, G. Gucluler, D. Bayik, A. Gursel, I. Gursel;
Ankara, Turkey
662
P6.06.090 - In vitro treatment of colon cancer cells with non-toxic concentration of 5-fluorouracil enhances
the effectiveness of tumor RNA-transfected DC vaccine
C.A. Araujo, J.C.L. Frederico, G.G. Romagnoli, M.B. Magalhães, J.P. Araujo Jr., Ramon Kaneno;
Botucatu, Brazil
663
P6.06.092 - Harnessing the IgA Fc RI receptor for antibody therapy
William Kelton, N. Mehta, T. Kang, J. Lee, T. Kojima, O. Lungu, M. Donkor, G. Georgiou;
Austin, United States
664
P6.06.093 - A new method for in vitro expansion of cytotoxic Natural Killer cells in gastro intestinal cancer
Ali Khodadadi, A. Asadirad, A. Talaiezadeh, A. Ghadiri, H. Galehdari, S. Mohaghegh hazrati, M. Oraki, G. Dinarvand, Y. Heike, A. Sheikhi;
Ahvaz, Iran, Islamic Republic of
665
P6.06.094 - KLF6-SV1 is overexpressed in T-cells from patients with chronic lymphocytic leukemia
Parviz Kokhaei, E. Mikaelsson, F. Mozaffari, A. Mosfegh, M. Hojat Farsangi, F. Pak, A. Österborg, H. Mellstedt;
Stockholm, Sweden
152
Posters - August 24
666
P6.06.095 - ImMucin, anti-MUC1 therapeutic Vaccine: Interim analysis from a phase I/II study in myeloma patients
Riva Kovjazin, O. Moran, I. Avivi, M.Y. Shapira, L. Carmon;
Nes-Ziona, Israel
667
P6.06.096 - Enhanced tumor antigen specific T cells in prostate cancer patients received in situ gene therapy of repeated
HSV-tk injection and ganciclovir administration
Makoto Kubo, T. Satoh, K. Tabata, K. Matsumoto, N. Yanagisawa, M. Saegusa, I. Okayasu, M. Iwamura, S. Baba, F. Obata;
Sagamihara, Japan
668
P6.06.097 - Development of the approach based on dendritic cells transfected with polyepitope DNA-construction for
stimulation of antitumor cytotoxic response in colorectal cancer
Ekaterina Kulikova, V. Kurilin, I. Obleuhova, Y. Shevchenko, V. Yakushenko, A. Sokolov, S. Sennikov;
Novosibirsk, Russian Federation
669
P6.06.098 - Receiving mature dendritic cells in vitro in patients with tumors of different localization
Vasily V. Kurilin, I.A. Obleuchova, E.V. Kulikova, J.N. Khantakova, J.A. Shevchenko, V.K. Yakuchenko, A.V. Sokolov, S.V. Sennikov;
Novosibirsk, Russian Federation
670
P6.06.099 - Recombinant lipidated HPV E7 induces a Th-1-biased immune response and protective immunity against
cervical cancer in a mouse model
C. Huang, J.J. Chen, K. Shen, L. Chang, Y. Yeh, Y. Chen, P. Chong, S. Liu, Chih-Hsiang Leng;
Zhunan Town, Miaoli,, Taiwan
671
P6.06.100 - In-vivo testing of PSMA-targeted T-cell immunotherapy for prostate cancer
Zhe Liu, S. Papa, J. Morris, J. Maher;
London, United Kingdom
672
P6.06.101 - Effects on apoptosis and cell cycle arrest contribute to the antitumor responses of interleukin-27
Lihua Liu, S. Baoen;
Shijiazhuang, China
673
P6.06.102 - Anti-tumor effect of folate-conjugated chitosan nanoparticles containing the IP-10 gene in mice with
hepatocellular carcinoma
X. Yu, Y. Xie, C. Lai, J. He, Y. Peng, S. Zhou, X. Xie, G. Luo, N. Zhou, Y. Zhao, Xiaoling Lu;
Nanning, China
674
P6.06.103 - Rapid and massive localization of multiple lymphocyte subsets to specific tissues following administration of
Interleukin-15
Enrico Lugli, H. Welles, K. Song, B.R. Bryant, C.K. Goldman, S. Rao, K.C. Conlon, T.A. Waldmann, M. Roederer;
Rozzano, Italy
675
P6.06.104 - Enhancing the effector functions of tumor-infiltrating lymphocytes with a combination of new genetic adjuvants
Alon Margalit, A. Pato, H. Weinstein-Marom, N. Levin, T. Peretz, A. Machlenkin, M. Lotem, G. Gross;
Kiryat Shmona, Israel
676
P6.06.105 - Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral
immune responses
Vanesa G. Martinez, R. Fenutría, I. Simões, V. Gil, J. Sintes, C. Raman, P. Engel, M. Ramos-Casals, G. Soldevila, F. Lozano;
Barcelona, Spain
677
P6.06.106 - T cell costimulation in cancer immunotherapy with anti-CD137 monoclonal antibodies is mediated by
K63-polyubiquitin-dependent signals from endosomes
Ivan Martinez-Forero, A. Arantza, B. Elixabeth, E. Nistal-Villan, A. Palazon, A. Teijeira, A. Morales-Kastresana, G. Perez-Chacon,
J. Zapata, I. Melero;
Pamplona, Spain
678
P6.06.107 - Chemokine-receptor modified Adoptive T cell Therapy (ACT)
S. Garetto, A. Trovato, Elisa Martini, R. Angioni, C. Soldani, M. Kallikourdis;
Rozzano, Italy
679
P6.06.108 - Competent dendrite cell maturation by cocktails containing TLR7/8 agonist for cancer immunotherapy
Farimah Masoumi, M. Nourizadeh, A. Memarian, R. Mirzaei, J. Hadjati;
Tehran, Iran, Islamic Republic of
680
P6.06.109 - Therapeutic effect of anti- pan HLA-class II mAb 4713 on human lymphoma cells, including Hodgkin lymphoma
and Adult T cell leukemia cell lines
Shuji Matsuoka, Y. Ishii, A. Nakao, H. Yagita, M. Abe, N. Mizutani, O. Naomi, K. Terashima, O. Hino;
Tokyo, Japan
681
P6.06.110 - Identification of unique colorectal cancer T-cell antigens by next generation sequencing of somatically
mutated genes
Daniele Mennonna, C. Maccalli, M. Romano, R. Bordoni, G. De Bellis, E. Orsenigo, L. Albarello, G. Casorati, G. Parmiani, P. Dellabona;
Milan, Italy
682
P6.06.111 - Examination of an immunoregulator in a syngeneic animal model
Giovanna Merchand-Reyes, M.A. Becerril-García, I. Gracia-Mora, S. Estrada-Parra, I. Estrada-Garcia, S.M. Perez-Tapia, C. SandovalMontes;
Mexico City, Mexico
683
P6.06.112 - Evaluation of anti-proliferative activity of ruthenium (III) compounds on human cancer cell lines using
RTCA - xCELLigence System
Mirela A. Mihaila, M. Bostan, G.G. Matei, V. Uivarosi, L.I. Brasoveanu;
Bucharest, Romania
684
P6.06.113 - Competent maturation of human dendritic cells by protein fractions of listeria monocytogenes
Reza Mirzaei, A. Saei, R. Boghozian, B. Vaziri, J. Hadjati;
Tehran, Iran, Islamic Republic of
153
Posters - August 24
685
P6.06.114 - Cloning and expression of human L- Asparaginase and study of its anti growth effect on leukemia cell lines
Leila Mohammadnejad, B. Baradaran, D. Shanehbandi, M. Pourhassan Moghaddam, S. Sadreddini;
Tabriz, Iran, Islamic Republic of
686
P6.06.115 - Exosomes displaying high expression of CD24 and HSP90 induced cellular and humoral immune response
“in vivo”
Claudia Mongini, J. De Toro, P. Di Sciullo, F. Menay, M. Gravisaco, A. Vendrell, C. Waldner, L. Hershlik;
Buenos Aires, Argentina
687
P6.06.116 - Imiquimod enhances anti-lymphoma response in a tumor cell lysate vaccine and inhibits tumor cells growth
Claudia Mongini, J. De Toro, L. Hershlik, M. Gravisaco, C. Waldner, P. Di Sciullo;
Buenos Aires, Argentina
688
P6.06.117 - Therapeutic activity of a combination of immunostimulatory monoclonal antibodies (anti-B7-H1, CD137 and
OX40) on a c-myc-driven spontaneous transgenic model of hepatocellular carcinoma
Aizea Morales-Kastresana, M.F. Sanmamed, I. Rodriguez, A. Palazon, I. Martinez-Forero, S. Labiano, S. Hervas-Stubbs, B. Sangro,
C. Ochoa, A. Azpilikueta;
Pamplona/Iruña, Spain
689
P6.06.118 - Establishment of human cancer stem-like cell targeting immunotherapy
Rena Morita, Y. Hirohashi, T. Torigoe, A. Takahashi, T. Terui, Y. Tamura, S. Hashino, A. Taketomi, S. Todo, N. Sato;
Sapporo, Japan
690
P6.06.119 - Schedule-dependent anticancer therapy by targeting TNF-alpha to tumor vessels in combination with melphalan
and gemcitabine
Lorenzo Mortara, P. Orecchia, P. Castellani, L. Borsi, B. Carnemolla, E. Balza;
Varese, Italy
691
P6.06.120 - High-level expression of IGFBP-3 by recombinant vaccinia virus leads to its incorporation into IMV and affects
virus replication and immunogenicity
Jan Musil, L. Kutinova, K. Zurkova, P. Hainz, K. Babiarova, J. Krystofova;
Prague, Czech Republic
692
P6.06.121 - Syntesis of matrix and matrix metalloproteases in 2D and 3D cultures of pancreatic cells
Ekaterina V. Myrsikova, E.N. Kaliberda, E.V. Svirshchevskaya;
Moscow, Russian Federation
693
P6.06.122 - Selective killing of activated B-cells and inhibition of antibody production with bispecific CD20 x CD95 antibodies
Kristina Nalivaiko, M. Hofmann, L. Grosse-Hovest, P.H. Krammer, H. Rammensee, G. Jung;
Tübingen, Germany
694
P6.06.123 - Modulating effects of different doses of 5-flurouracil (5-FU) on the maturation and function of dendritic cells (DC)
in vitro
Afshin Namdar, M. Hafezi, N. Khosravianfar, A. Rezaei, J. Hadjati;
Isfahan, Iran, Islamic Republic of
695
P6.06.124 - Outer membrane proteins and vesicle proteins targeted as new vaccine strategies for pathogenic gram negative
bacteria through particulate delivery system
Bismita Nayak, P.R. Rauta;
Rourkela, India
696
P6.06.125 - Down-regulation of pro-angiogenic and pro-metastatic genes in scFvs treated breast cancer cells
Foroogh Nejatollahi, V. Younesi, M. Asgharpour;
Shiraz, Iran, Islamic Republic of
697
P6.06.126 - Down-regulation of Epidermal Growth Factor in a breast cancer cell line treated with anti-HER2 single chain
antibodies
Foroogh Nejatollahi, M. Asgharpour, V. Younesi;
Shiraz, Iran, Islamic Republic of
698
P6.06.127 - IL-12 immunotherapy: characterization of a CD4+ effector population
Megan E. Nelles, C.L. Furlonger, J.A. Medin, C.J. Paige;
Toronto, Canada
699
P6.06.128 - EBV-transformed Lymphoblastoid Cell Lines as Vaccines against Cancer Testis Antigen-positive Tumors
Frank Neumann, D. Kaddu-Mulindwa, T. Widmann, K.D. Preuss, G. Held, C. Zwick, K. Roemer, M. Pfreundschuh, B. Kubuschok;
Homburg, Germany
700
P6.06.129 - ENO1-specific Tregs frustrate Th1/Th17 effector cells isolated from pancreatic cancer patients
Elena Niccolai, P. Cappello, C. della Bella, M. Benagiano, F. Cianchi, L. Bencini, F. Novelli, M. D’Elios, A. Amedei;
Florence, Italy
701
P6.06.130 - IgE as a new player in tumor surveillance
Elisa Agnese Nigro, V. Yenagi, E. Soprana, A.T. Brini, A.G. Siccardi, L. Vangelista;
Milan, Italy
702
P6.06.131 - First exploration of clinical value of telomerase expression in triple-negative breast cancer tissues
Malyshev Nikolay, E. Gross, R. Napieralski, H. Jansen, F. Yang, M. Kiechle, M. Aubele, M. Schmitt;
Munich, Germany
703
P6.06.132 - Tumor-associated antigen-specific CD4+ T-cell immunity augmented by CTL-epitopes vaccination in patients
with malignant tumor
Y. Tomita, A. Yuno, H. Tsukamoto, Y. Yoshitake, T. Tsunoda, Y. Nakamura, M. Shinohara, Yasuharu Nishimura;
Kumamoto, Japan
154
Posters - August 24
704
P6.06.133 - Effect of mature dendritic cells primed with autologous tumor antigens, patients with epithelial ovarian cancer
to stimulate the cytotoxic activity of mononuclear cells in vitro
Irina Obleuhova, V. Kurilin, M. Goncharov, A. Tarkhov, S. Krasilnikov, S. Sennikov;
Novosibirsk, Russian Federation
705
P6.06.134 - Immunotherapeutic and toxic effects of a triple fusion protein encompassing apolipoprotein A-I,
interleukin-15 and the interleukin-15 receptor sushi domain
Maria C. Ochoa, J. Fioravanti, R. Inmaculada, S. Hervas-Stubbs, A. Azpilicueta, G. Mazzolini, A. Gurpide, J. Prieto, P. Berraondo, I. Melero;
Pamplona, Spain
706
P6.06.135 - Cytotoxic effect of methanolic fractions of Scrophularia oxysepala on MCF-7 human breast cancer cell line
Mona Orangi, B. Baradaran, T. Kazemi, A. Pasdaran, J. Majidi Zolbanin, B. Hosseini, L. Mohammadnejad;
Tabriz, Iran, Islamic Republic of
707
P6.06.136 - Discovery of chemotherapy induced ovarian cancer antigens by interrogating memory T cells
Fabio Palombo, M. Paroli, F. Bellati, M. Videtta, T. Donato, C. Mancone, D. Accapezzato, S. Piconese, P. Benedetti Panici, V. Barnaba;
Rome, Italy
708
P6.06.137 - G1-4A, a polysaccharide from T. Cordifolia induces killer phenotype and increases dendritic cell immunogenicity
in murine lymphoma model
Vipul K. Pandey, B. Shankar, K.B. Sainis;
Mumbai, India
709
P6.06.138 - Bivalent CD28 agonistic aptamer: a novel adjuvant-vaccine for lymphoma
Fernando Pastor, M.M. Soldevilla, H. Villanueva, S. Inoges, A.L. de Cerio, M. Bendandi;
Pamplona, Spain
710
P6.06.139 - Abrogation of tumor-associated immunosuppression by targeting tumor-infiltrating regulatory T-cell function can
restore impaired T cell responses in patients with liver cancer
Alexander Pedroza Gonzalez, J. Kwekkeboom, S.P. Singh, E. Tjwa, W.G. Polak, D.J. Grünhagen, K. Biermann, J.N.M. Ijzermans,
H.L.A. Janssen, D. Sprengers;
Rotterdam, Netherlands
711
P6.06.140 - Cancer from hell: Devil Facial Tumour Disease
Terry Pinfold, G. Brown, A. Kreiss, G. Woods;
Hobart, Australia
712
P6.06.141 - Expression patterns of cancer/testis antigens constitute a stable patient-specific fingerprint in multiple recurrent
lesions of evolving metastatic melanoma
Zoltan Pos, J.R. Wunderlich, D.F. Stroncek, J.A. Malek, P.F. Robbins, L. Rivoltini, M. Maio, L. Chouchane, E. Wang, F.M. Marincola;
Budapest, Hungary
713
P6.06.142 - Targeting Th17-associated cytokines with a bi-specific antibody improves anti-myeloma responses
Rao H. Prabhala, M. Fulciniti, J. Bae, A. Nigroiu, S. Lee, J.F. Daley, M. Marelli, K. Grabstein, K.C. Anderson, N.C. Munshi;
Boston, United States
714
P6.06.143 - Anti-tumor activities of human Vγ9Vδ2 T cells in combination with zoledronic acid in a pre-clinical model
of neuroblastoma
E. Di Carlo, P. Bocca, L. Emionite, M. Cilli, G. Cipollone, F. Morandi, L. Raffaghello, V. Pistoia, Ignazia Prigione;
Genoa, Italy
715
P6.06.144 - Analysis of IL-10 serum levels in epithelial ovarian carcinoma in comparison to Ovarian benign Cyst
S. Rezaeifard, Shahrzad Rahimifar, M. Razmkhah;
Shiraz, Iran, Islamic Republic of
716
P6.06.145 - Equipotent antagonism towards both ligands and excellent anti-tumor efficacy with a peptide inhibitor
of PD-1 immune check point pathway
P.G. Sasikumar, R.K. Shrimali, L.K. Satyam, S. Adurthi, R. Ramachandra, S. Vadlamani, K.A. Reddy, D.S. Samiulla, K. Sunilkumar,
Murali Ramachandra;
Bangalore, India
717
P6.06.146 - Development of a monoclonal antibody against the canine CCR2 as a new targeted anticancer therapy in the
scope of comparative oncology
Teresa P. Raposo, D.J. Argyle, B.C.B. Beirao, I. Pires, F.L. Queiroga;
Vila Real, Portugal
718
P6.06.147 - Anti EGFR monoclonal antibody inhibits prostate cancer PC3 cells growth
Alireza Rezaiemanesh, J. Majidi, B. Baradaran, A. Movasaghpour, A. Nakhlband, J. Barar, Y. Omidi;
Tehran, Iran, Islamic Republic of
719
P6.06.148 - Characterization of a genetic mouse model of lung cancer: a promise to identify oncoantigens associated with
different stages of NSCLC progression
Federica Riccardo, M. Arigoni, M. Iezzi, D.L. Longo, M. Carrara, A. Fiore, G. Forni, R.A. Calogero, E. Quaglino, F. Cavallo;
Torino, Italy
720
P6.06.149 - Tumour vaccine for oral cancer: prospects and challenges
Gabriel Rodrigues;
Manipal, India
721
P6.06.150 - Multifaceted immunotherapeutic effects of vitamin D-binding protein-derived macrophage activating factor
(GcMAF) on human breast cancer and neuroblastoma cells
Marco Ruggiero, S. Pacini, G. Morucci, J.J.V. Branca, E. Ward, R.J. Smith, L. Thyer, M. Gulisano;
Firenze, Italy
722
P6.06.151 - In vitro cytotoxic effects of dichloromethane extract of Scrophularia atropatana on WEHI-164 cells
Elham Safarzadeh, B. Baradaran, A. Delazar, T. Kazemi, M. Orangi, D. Shanehbandi, S. Esnaashari;
Tabriz, Iran, Islamic Republic of
155
Posters - August 24
723
P6.06.152 - Tumour cell lysate loaded-Dendritic Cell vaccine induces biochemical and memory immune response in
castration-resistant prostate cancer patients
D. Reyes, C. Pereda, E. Castellón, R. Valdenevito, M. López, Flavio Salazar-Onfray;
Santiago, Chile
724
P6.06.153 - Evaluation of anti-FoxP3 vaccine efficacy following DNA-protein prime-boost immunization in mice
Morteza Samadi, A. Memarnejadian, R. Vahabpour, S. Sadat, M. Aghasadeghi, J. Hadjati;
Yazd, Iran, Islamic Republic of
725
P6.06.154 - The relevance of heat shock protein 90 and its role in cancer treatment
Alessandra Santos, B. Campostrini, M. Geller, A. Abrahão, L. Oliveira, K. Cunha, A. Fonseca, M. Ribeiro, M. Romero, E. Naliato;
Rio de Janeiro, Brazil
726
P6.06.155 - Pseudo-exhaustion of CD8+ T cells in acute myeloid leukemia (AML)
Frauke M. Schnorfeil, K. Emmerig, J. Neitz, F.S. Lichtenegger, R. Draenert, W. Hiddemann, M. Subklewe;
Munich, Germany
727
P6.06.156 - Functionalized polyethyleneimine-based nanoparticles improve antigen cross-presentation of murine bone
marrow derived macrophages and dendritic cells depending on size and zeta potential
Matthias Schröder, A. Schallon, M. Wagner, M. Gottschaldt, U. Schubert, P. Knolle;
Bonn, Germany
728
P6.06.157 - Immunopharmacodynamic response to blinatumomab in patients with relapsed/refractory B-precursor acute
lymphoblastic leukaemia (ALL)
Andrea Schub, V. Nägele, G. Zugmaier, C. Brandl, Y. Hijazi, M.S. Topp, P. Kufer, A. Wolf, M. Klinger;
Munich, Germany
729
P6.06.158 - Role of the transcription factor forkhead box P3 in breast cancer and metastasis
Lucia Sfondrini, A. Cataldo, V. Uva, T. Triulzi, P. Casalini, E. Tagliabue, A. Balsari;
Milan, Italy
730
P6.06.159 - Production of lacZ inducible T cell hybridoma specific for human and mouse gp10025-33 peptides
Adi Sharbi-Yunger;
Rehovot, Israel
731
P6.06.160 - Dendritic cells transfected with allel-specific polyepitope DNA-constructs stimulate cytotoxic response
mononuclear cells of breast cancer patients in vitro
Yulia A. Shevchenko, S. Sennikov, Y.N. Khantakova, V.V. Kurilin, Y.A. Lopatnikova, S.V. Sidorov, A.Z. Maksyutov, R.A. Maksyutov, E.V.
Gavrilova, S.A. Zaytsev;
Novosibirsk, Russian Federation
732
P6.06.161 - Supportive involvement of tumor-associated myeloid cells in RNA adjuvant therapy for cancer
Hiroaki Shime, M. Matsumoto, T. Seya;
Sapporo, Japan
733
P6.06.162 - The cross-talk between plasmacytoid DC and conventional DCs shapes the anti-tumor memory CD8+T cells
Kanako Shimizu, S. Fujii;
Yokohama, Japan
734
P6.06.163 - Immunization against tumor-associated macrophages - enhancement of DNA vaccine potency against legumain
Michal Smahel, M. Duskova, I. Polakova, J. Musil, M. Petrackova;
Prague, Czech Republic
735
P6.06.164 - New role for Toll-like receptor 9 agonists, CpG-ODN as cancer cell “chemosensitizer”
Michele Sommariva, L. Sfondrini, L. De Cecco, E. Wang, E. Tagliabue, A. Balsari;
Milan, Italy
736
P6.06.166 - Dual targeting by TCR-redirected T cells enables remission from autochthonous mouse prostate cancer and
long-term disease-free survival
T. Manzo, Tabea Sturmheit, V. Basso, R. Hess Michelini, I. Olvera Gomez, T. Schumacher, M. Bellone, A. Mondino;
Milan, Italy
737
P6.06.167 - Targeting the self-antigen nucleolin for antibody immunotherapy of breast and other cancers
Natalie Sutkowski, W. Sun, D. Fernandes, S. Rubinchik;
Charleston, United States
738
P6.06.168 - Low dose radiation-mediated enhanced effector function regulated by the ERK1/2 pathway in human T cells
Zsuzsanna Tabi, L.K. Spary, S. Al-Taei, J. Salimu, A. Clayton, J. Staffurth, M.D. Mason;
Cardiff, United Kingdom
739
P6.06.169 - Enhancement of antigen-specific CTL inducing ability in the leukemic plasmacytoid dendritic cell line (PMDC11)
by lentiviral vector-mediated transduction of caTLR4 gene
Masuhiro Takahashi, M. Iwafuchi, A. Yamahira, N. Satoh, T. Uchiyama, S. Hashimoto, A. Bonehill, E. Faure-Kumar, N. Kasahara, M. Narita;
Niigata, Japan
740
P6.06.170 - TAPCells based vaccination induce specific anti NY-ESO1 immune response in melanoma patients
F. Tempio, P. Guerrero, F. Falcon-Beas, I. Flores, C. Falcon-Beas, J. Gatica, F. Salazar-Onfray, Mercedes N. Lopez;
Santiago, Chile
741
P6.06.171 - HSV-1 activated plasmacytoid dendritic cells inhibit melanoma cell growth
Sabrina Thomann, J.B. Boscheinen, B. Schuler-Thurner, S. Groß, B. Schmidt;
Erlangen, Germany
742
P6.06.172 - Polysaccharide nanocomplexes harboring split vaccine and TLR ligands are potent vaccine carriers against influenza
Gizem Tincer, C. Coban, K. Ishii, I. Gursel;
Ankara, Turkey
156
Posters - August 24
743
P6.06.173 - Protein chimera of IL-2-S4B6 mAb exerts similar or even higher biological activity as IL-2/S4B6 mAb
immunocomplexes in vivo
Jakub Tomala, J. Kovarova, M. Kabesova, P. Votavova, H. Chmelova, B. Dvorakova, B. Rihova, M. Kovar;
Prague, Czech Republic
744
P6.06.174 - Search for an association between JC virus (JCV) and colorectal cancer in Tunisian patients
Wafa Toumi, A. Ripalti, L. Ricciardiello, A. Cherif, J. Kharrat, M. Jendoubi, F. Ghoul, L. Satouri, M. Zili, R. Khelifa;
Tunis, Tunisia
745
P6.06.175 - Chemotherapy can enhance trastuzumab-mediated ADCC
Tiziana Triulzi, L. Sfondrini, S. Varchetta, V. Regondi, M. Sasso, P. Casalini, G. Bianchi, G. Mariani, A. Balsari, E. Tagliabue;
Milan, Italy
746
P6.06.176 - Osteosarcoma antigen PBF-derived peptides could elicit immunological response in patients with refractory
osteosarcoma
Tomohide Tsukahara, M. Emori, A. Takahashi, T. Torigoe, T. Yamashita, N. Sato, T. Wada;
Sapporo, Japan
747
P6.06.177 - Tattoo delivery of Semliki Forest virus-based immunization strategies against cervical cancer
Stephanie van de Wall, T. Daemen;
Groningen, Netherlands
748
P6.06.178 - A new identified CD20-spliced protein as potential target for T cell-based immunotherapy in B-cell
lymphoma/leukemia patients
Charline Vauchy, C. Gamonet, E. Daguindau, C. Henry, P. Rohrlich, O. Adotevi, C. Borg, C. Ferrand, Y. Godet;
Besançon, France
749
P6.06.179 - Immunotherapy for the liver metastases prevention with a vaccine strain of an attenuated Salmonella Typhi
Alejandrina Vendrell, A. Tesone, J. De Toro, L. Herschlik, M. Gravisaco, J. Goin, G. Larotonda, C. Mongini, C. Waldner;
Buenos Aires, Argentina
750
P6.06.180 - Antitumor activity of a Salmonella Typhi vaccine strain in a mouse model of T-cell lymphoma
Alejandrina Vendrell, A. Tesone, J. De Toro, L. Herschlik, M.J. Gravisaco, J.C. Goin, G. Larotonda, C. Mongini, C.I. Waldner;
Buenos Aires, Argentina
751
P6.06.181 - Lcn2 secreted from DCs induces CD8+ T-cell apoptosis, it is involved in T-cell priming, and upon DCs vaccination
trigger a Th1 phenotype
M. Floderer, M. Prchal, J. Warszawska, S. Knapp, T. Felzmann, Caterina Vizzardelli;
Vienna, Austria
752
P6.06.182 - Allogeneic dendritic cells induce potent antitumor immunity by activating KLRG1+CD8 T cells
Chao Wang, Z. Zhu, Y. Wu, X. Liu, Y. Wang, Z. Li, D. Peng, Z. Chang, X. Cao, M. Zhang;
Beijing, China
753
P6.06.183 - Expression of cancer testis antigens (CTAs) and its correlation with clinical parameters in Chinese hepatocellular
carcinoma
Meng Wang, J. Li, Y. Zhao, D. Li, Z. Fan, Y. Sun, Z. Tang, Z. Li, S. Wu, Y. Zhang;
Zhengzhou, China
754
P6.06.184 - Cell surface delivery of TRAIL strongly augments the tumoricidal activity of T-cells
Valerie R. Wiersma, M. de Bruyn, D.F. Samplonius, W. Helfrich, E. Bremer;
Groningen, Netherlands
755
P6.06.185 - NK depletion enhances the rejection of established melanoma by tumor-specific CD4+ T cells
Kyle A. Wilson, S.R. Goding, K.M. Harris, H.R. Neeley, P.A. Antony;
Baltimore, United States
756
P6.06.186 - IL-17A promotes immune cell recruitment in human esophageal cancers
Jian-chuan Xia, L. Lv, K. Pan;
Guangzhou, China
757
P6.06.187 - The effects of esomeprazole combined with classical cancer drugs on lung cancer cells and peripheral blood
mononuclear cells
Arzu Yılmaztepe Oral, &. Korkmaz, F. Budak, G. Özkaya, E. Ulukaya, H. Oral;
Bursa, Turkey
758
P6.06.188 - Establishment of a lymphoblastoid cell line with B1 cell characteristics derived from a chronic lymphocytic
leukemia patient by in vitro EBV transformation
Vahid Younesi, H. Nikzamir, M. Hojjat-Farsangi, S. Razavi, F. Shokri;
Shiraz, Iran, Islamic Republic of
759
P6.06.189 - Identification of surface molecules with enzymatic and signaling proprieties as targets for mAb-immunotherapy
of human prostate cancers
Gianluca Zaccarello, A. Zitella, V. Quarona, L. Daniele, G. Chiorino, M. Bellò, A. Tizzani, A.L. Horenstein, G. Bisi, F. Malavasi;
Torino, Italy
760
P6.06.190 - Modulation of tumor microenvironment associated with tumor regression in melanoma patients receiving
adoptive cell transfer therapy
Juhua Zhou, B. Xiao, J. Sun, Z. Liu, Y. Zhong, G. Zhang, X. Chi, Q. Huang;
Yantai, China
761
P6.06.191 - A tumor vaccine against chronic lymphocytic leukemia
Fang Zhu, R. Gorczynski, D.E. Spaner;
Toronto, Canada
157
Posters - August 24
762
P6.06.192 - Construction and functional activity of shRNA targeting Wnt-1 gene hyperexpressed by Wnt-1 breast tumors
in mice
Dmitrii A. Zubkov, A.A. Lysenko, E.V. Smirnova, A.A. Zubareva, E.V. Svirshchevskaya;
Moscow, Russian Federation
P6.16 BIOMARKERS AND CLINICAL PROFILING OF HUMAN IMMUNE RESPONSES
Session Time: Saturday, August 24, 13:20 - 15:00
763
P6.16.01 - Slceroderma: from clinical classification to autoantibodies profile
R. Assandri M. A. Montanelli;
Rozzano, Italy
764
P6.16.02 - Biomarkers associated with treatment failure in Kawasaki disease
Jun Abe, S. Fukuda, H. Masuda, N. Sakamoto, S. Oana, H. Kato;
Tokyo, Japan
765
P6.16.03 - Is Basophil Activation Test as a Safe Diagnostic Tool for Immediate Drug Hypersensitivity to Proton-Pump Inhibitors?
Nilgun Akdeniz, L. Pur Ozyigit, B. Ertek, B. Aydin, D. Unal, M. Demirturk, A. Gelincik, S. Buyukozturk, B. Colakoglu, G. Deniz;
Istambul, Turkey
766
P6.16.04 - HLA-G 14-bp Deletion/Insertion, 3003C/T, 3010C/G and 3027A/C polymorphisms in HTLV-1 infection
Daiani C.C. Alves, M. Rocha-Júnior, R. Haddad, W. Virginia, O. Takayanagui, D. Covas, S. Kashima, E.A. Donadi;
Ribeirão Preto, Brazil
767
P6.16.05 - Different In vitro profiles of biologicals in human PBMC lymphocytes activation assay
Filippo Andreetta, E. Vicentini, F. Zanderigo, E. Zambello, J. Chappell;
Verona, Italy
768
P6.16.06 - Standardization of ELISPOT counts for accurate assessment of human T cell responses performed by 10 different
laboratories
Tameem Ansari, A.Y. Karulin, P.V. Lehmann, S. Sundararaman;
Shaker Heights, United States
769
P6.16.07 - A novel mechanism for recognition of a small molecule carbohydarte immunotherapeutic by human myeloid cells:
Potential for modulation of efficacy in the clinic
Mary A. Antonysamy, M.I. Nelson, R. Walsh, N.R. Ottoson, B. Rathmann, W. Grossman;
Eagan, United States
770
P6.16.08 - Surface Plasmon Resonance Imagery-based strategy to study hnRNPA2/B1 peptides as specific biomarkers in
systemic lupus erythematosus, rheumatoid arthritis and autoimmune hepatitis
E. Beleoken, H. Leh, Eleonora De Martin, C. Johanet, D. Samuel, J. Duclos-Vallée, M. Buckle, E. Ballot;
Villejuif, France
771
P6.16.09 - A novel cell-based assay for measuring neutralizing autoantibodies against type I interferons in patients with
autoimmune polyendocrine syndrome type 1
Lars Breivik, E. Bratland, A. Hellesen, B. Oftedal, A.S. Bøe Wolff, E.S. Husebye;
Bergen, Norway
772
P6.16.10 - Increased circulating levels of leukocytes, lymphocytes and atypical lymphocytes in patients with dengue hemorrhagic fever
A.I.V. Fernandes, F.J. Rolim, L.H. Simões, Lucio R. Castellano;
João Pessoa Paraíba, Brazil
773
P6.16.11 - Cancer Testis Antigens Expression: Sex and Multiple Myeloma
Maurizio Chiriva-Internati, L. Mirandola, Y. Yu, M. Jenkins, J.A. Figueroa, E. Cobos;
Lubbock, United States
774
P6.16.12 - Cancer treatment and diagnosis using cancer testis antigens for multiple myeloma
Maurizio Chiriva-Internati, L. Mirandola, Y. Yu, F. Hardwicke, N. D’Cunha, L. Tijani, D.D. Nguyen, J.A. Figueroa, E. Cobos;
Lubbock, United States
775
P6.16.13 - The cancer/testis antigens, SP17, AKAP4, and PTTG1 are expressed in non-small cell lung cancer: new biomarkers
and vaccine targets
Maurizio Chiriva-Internati, L. Mirandola, Y. Yu, C. Jumper, R. Alalawi, J.A. Figueroa, E. Cobos;
Lubbock, United States
776
P6.16.14 - Proteomic analysis of aqueous humor from uveitis patients
Pitipol Choopong, N. Tesavibul, V. Thongboonkerd;
Bangkok, Thailand
777
P6.16.15 - Intracellular modulation, extracellular disposal and serum circulating increase of miR-150 upon lymphocyte
activation
Paola de Candia, A. Torri, T. Gorletta, E. Bulgheroni, M. Fedeli, L. Romanò, S. Esposito, G. Casorati, M. Pagani, S. Abrignani;
Milan, Italy
778
P6.16.16 - Identification of biomarkers associated with treatment for latent tuberculosis by microarray
Eleane de Oyarzabal, T. Herrera, L. Orozco, C. Rangel-Escareño, L. Ferreyra-Reyes, P. Cruz-Hebert, L. Garcia-Garcia, R.J. Wilkinson,
E. Sada, M. Torres;
Mexico, Mexico
779
P6.16.17 - Novel monoclonal antibodies against human Carbonic Anhydrase XII, a potential biomarker of tumor cells
Dovile Dekaminaviciute, R. Lasickiene, M. Zilnyte, V. Jogaite, V. Michailoviene, S. Parkkila, D. Matulis, A. Zvirbliene;
Vilnius, Lithuania
158
Posters - August 24
780
P6.16.18 - Tertiary lymphoid structures have features of an ongoing humoral immunity with a benefit for lung cancer
patients
Marie-Caroline Dieu-Nosjean, F. Tamzalit, C. Germain, A. Lepelley, R. Remark, A. Lupo, D. Damotte, P. Validire, W. Fridman,
C. Sautès-Fridman;
Paris, France
781
P6.16.19 - Assessment the immune responses in the microenvironment of breast cancer tissues
Rahil Eftekhari, H. Shirzad, R. Esmaeili, K. Majidzadeh, J. Hadjati;
Tehran, Iran, Islamic Republic of
782
P6.16.20 - Molecular allergology : Component resolved diagnostics for managing cow’s milk allergy in West Algeria
Kamel Eddine El Mecherfi, W. Hachelaf, G. Boudraa, H. Rabesona, Y. Choiset, J. Chobert, O. Kheroua, M. Touhami, T. Haertlé,
D. Saidi;
Oran, Algeria
783
P6.16.21 - Timing of blood sampling for CD4 T-cell count influences HAART decisions
Yonas B. Feyissa;
Addis Ababa, Ethiopia
784
P6.16.22 - ACTC1, CCR5, TNF/LTA, CCL2, IL12B, IL10, MAL/TIRAP genes are associated to the development of Chronic Chagas
disease cardiomyopathy
Amanda F. Frade-Barros, P.C. Teixeira, M. Baron, B. Ianni, A.C. Pereira, C.W. Pissetti, V. Rodrigues, J. Kalil, C. Chevillard,
E. Cunha-Neto;
Sao Paulo, Brazil
785
P6.16.23 - Serological proteome analysis (SERPA) as a tool for the identification of tumor antigens capable of eliciting
immune responses in chronic lymphocytic leukemia (CLL)
Valentina Griggio, G. Mandili, C. Vitale, M. Capello, F. Novelli, M. Boccadoro, M. Massaia, M. Coscia;
Torino, Italy
786
P6.16.24 - Impact of excipients and pH on the in vitro hemolysis by IgG solutions
Andrea Heger, A. Zöchling, G. Kohla, T. Svae, J. Römisch;
Vienna, Austria
787
P6.16.25 - Exhausted CD8 T cells in peripheral blood of breast cancer patients
Joselin Hernandez-Ruiz, C. Lara-Gutierrez, H. Miranda-Hernandez, E. Gutierrez-Reyes;
Mexico, Mexico
788
P6.16.26 - The impact of polymorphisms in the host immune response genes on the severity of chronic hepatitis C
Xuan S. Hoang, M. Thelu, E.J. Marche, N. Sturm, V. Leroy, J.P. Zarski, P. Marche;
Grenoble, France
789
P6.16.27 - Peptide Microarrays with Near Zero background enable high quality and massive data production from
seroscreening of autoimmune diseases
Mo Huang, Y. Lu, C. Liu, Z. Li, X. Liu, H. Ma;
Suzhou, China
790
P6.16.28 - Chronic myeloid leukemia patients in prolonged remission after interferon monotherapy have constantly
active NK-cells
Mette M. Ilander, A. Kreutzman, P. Rohon, T. Melo, E. Faber, K. Porkka, J. Vakkila, S. Mustjoki;
Helsinki, Finland
791
P6.16.29 - Neutrophil gelatinase-associated lipocalin in chronic heart failure
Nilgun Isiksacan, M. Koser, M. Erturk, I. Akturk, S. Yazan, M. Yildirim, V. Ornek Diker, I. Bakir;
Istanbul, Turkey
792
P6.16.30 - Post-traumatic Immunosuppression and its Reversal
Nahidul Islam, M. Whitehouse, S. Mehandale, M. Hall, A. Blom, G. Bannister, J. Hinde, R. Ceredig, B. Bradley;
GALWAY, Ireland
793
P6.16.31 - Monocyte surface antigen expression in severe sepsis
Joel Jamsa, V. Huotari, E. Savolainen, H. Syrjala, T. Ala-Kokko;
Oulu, Finland
794
P6.16.32 - Change in immune cells population following exposure to the venom from Hemiscorpius lepturus scorpion
venom
Ali Khodadadi, M. Pipelzadeh, Y. Heike, M. Assarehzadegan, B. Vazirianzadeh;
Ahvaz, Iran, Islamic Republic of
795
P6.16.33 - Clinical utility of interferon-γ releases assay (IGRAs) in new and retreated cases of Pott’s disease at a tertiary care
hospital
Manoj Kumar, R. Kumar, A.K. Srivastava, V.L. Nag, N. Krishnani, A.K. Maurya, T.N. Dhole, S.G. Babu;
Lucknow, India
796
P6.16.34 - Collagen Triple Helix Repeat Containing 1 (CTHRC1) Acts via ERK-Dependent Induction of MMP9 to Promote
Invasion of Colorectal Cancer Cells
J. Kim, Y. Choe, B. Kim, K. Kim, J. Kim, S. Lee, Hee Gu Lee;
Daejeon, Korea, Republic of
797
P6.16.35 - High expression of prolactin receptor is associated with cell survival of cervical cancer cells
Edgar I. López-Pulido, R. Ascencio-Cedillo, J.F. Muñoz-Valle, S. Del Toro-Arreola, C. Estrada-Chávez, A.L. Pereira-Suárez;
Guadalajara, Mexico
798
P6.16.36 - A standardized long-term culture assay to measure antigen-specific memory T cells
Franco Lori, G. Cugia, C. Pisano, D. De Forni, T. Bitai, S.A. Calarota, J. Lisziewicz;
Alghero, SS, Italy
159
Posters - August 24
799
P6.16.37 - Development of the MeDALL allergy-chip, an allergen micro-array comprising 176 components for sensitive
detection of allergen-specific antibodies
Christian Lupinek, E. Wollmann, J. Bousquet, J.M. Anto, C. Harwanegg, R. Valenta;
Vienna, Austria
800
P6.16.38 - Association between reduction of plasma adiponectin levels and risk of bacterial infection after gastric cancer
surgery
Kazuhisa Maeda, H. Yamamoto, Y. Uji, H. Tsuchihashi, T. Shimizu, Y. Endo, A. Kadota, K. Miura, T. Ito, T. Tani;
Suita, Osaka, Japan
801
P6.16.39 - Mitral valve proteomic analysis: novel insights into rheumatic heart disease mechanisms
Carlo O. Martins, K.S. Santos, F.M. Ferreira, E. Cunha-Neto, J. Kalil, L. Guilherme;
São Paulo, Brazil
802
P6.16.40 - Transient alteration in cytokine patterns following influenza vaccination detected by Ki-67 expression and
automated multiparameter analysis of flow cytometry
Tim R. Mosmann, D. Roumanes, I. Naim, A. Rosenberg, J. Weaver, Y. Qi, A.M. Livingstone, G. Sharma;
Rochester, United States
803
P6.16.41 - Recurrent ulcerative stomatitis and its correlation with psychological factors
Mohammad Naghavi - Behzad, A. Naghavi-Behzad, M. Ghojazadeh, R. Piri, F. Pournaghi Azar;
Tabriz, Iran, Islamic Republic of
804
P6.16.43 - Serum hepcidin levels in patients with Brucellosis
E. Yılmaz, A. Oguz Ayarcı, D. Sıgırlı, M. Öner Torlar, F. Budak, G. Göral, Haluk B. Oral;
Bursa, Turkey
805
P6.16.44 - A unique endotoxin tolerance profile strongly predominates during clinical sepsis
Olga M. Pena, D.G. Hancock, J. Xia, C.D. Fjell, R.E.W. Hancock;
Vancouver, Canada
806
P6.16.45 - Changes in IgA and IgM in saliva and serum of newborns during the first 30 days of life
Sandra Pineda-Martínez, J. Hernández-Islas, B. Tecuatl-Herrada, D. Correa;
Mexico City, Mexico
807
P6.16.46 - Lipid profile analysis in spinal trauma patients shows severe distortion of AA/DHA after injury
Danuta Radzioch, J.B. De Sanctis, G. Wojewodka, M. Radhakrishna, I. Makriyianni, S. Parent, J. Ouellet, S. David;
Montreal, Canada
808
P6.16.47 - Kinetics of inflammatory markers following traumatic injuries to the spinal cord
Danuta Radzioch, G. Wojewodka, S. David, I. Makriyianni, M. Radhakrishna, S. Parent, J. Ouellet;
Montreal, Canada
809
P6.16.48 - Circulating IL-12 and response to therapy in HCV-infected patients: Potential biomarker for a non-favorable
outcome?
F.A. Pereira, L.A.O. Pereira, T.M.A. Carmo, R. Paraná, A.T. Carvalho, O.A. Martins-Filho, J. Hagan, E.A.G. Reis, Mitermayer G. Reis;
Salvador/Ba- Brazil, Brazil
810
P6.16.49 - Association of IL28B (rs12979860) and IL-12B (rs3212227) polymorphisms with response to HCV-therapy inpatients
with a mixed genetic background
F.A. Pereira, L.A.O. Silva, T.M.A. Carmo, J. Hagan, R. Paraná, Mitermayer G. Reis;
Salvador/Ba- Brazil, Brazil
811
P6.16.50 - HLA-G expression is an independent predictor for survival in high grade ovarian carcinomas
Marianne J. Rutten, D. Meijer, M.R. Buist, M.J. Van de Vijver, G.G. Kenter, E.S. Jordanova;
Amsterdam, Netherlands
812
P6.16.51 - Phenotypic signature of B cell subsets as a tool for the investigation of immunogenicity
William J. Sanderson, E.C. Jury, J. Manson, C. Mauri;
London, United Kingdom
813
P6.16.52 - Role of the immunity in the aggressive forms of breast cancer seen in Western Kenya
Rispah T. Sawe;
Eldoret, Kenya
814
P6.16.53 - Gastrointestinal autoimmunity to tryptophan hydroxylase in Autoimmune Polyendocrine Syndrome type 1 (APS-1)
Riccardo Scarpa, R. Alaggio, L. Norberto, B. Smith, M. Plebani, F. De Luca, M. Salerno, L. Ghizzoni, C. Betterle;
Padova, Italy
815
P6.16.54 - Blood pulmonary tuberculosis biomarkers on diabetic individuals
Carmen J. Serrano, R.A. González, L. Enciso, N. Macías, J.A. Enciso;
Zacatecas, Mexico
816
P6.16.55 - Anti-carbamylated protein antibodies (Anti-CarP) precede the onset of Rheumatoid Arthritis
Jing Shi, L.A. van de Stadt, E.W.N. Levarht, T.W.J. Huizinga, D. Hamann, D. van Schaardenburg, R.E.M. Toes, L.A. Trouw;
Leiden, Netherlands
817
P6.16.56 - An innovative method to identify autoantigens expressed on the cell surface: SARF
T. Shirai, Hiroshi Fujii, M. Ono, R. Watanabe, Y. Shirota, S. Saito, T. Ishii, H. Harigae;
Sendai, Japan
818
P6.16.57 - Significant cancer-associated autoantibody signatures for early diagnosis and prognosis of gastric cancer
Karina Silina, P. Zayakin, G. Ancans, Z. Kalnina, I. Meistere, A. Pismennaya, M. Leja, A. Line;
Riga, Latvia
160
Posters - August 24
819
P6.16.58 - Rates of Persistent Positivity for Anti-Cardiolipin and Anti-Beta-2-Glycoprotein I Antibodies in Routine Clinical
Practice
Melissa R. Snyder, M.W. Ettore;
Rochester, United States
820
P6.16.59 - The effect of dipeptidyl peptidase-IV inhibitor sitagliptin on the immune functions in patients with
type 2 diabetes
Lucie Sromova, P. Bušek, H. Mareckova, M. Andel, A. Sedo;
Prague 2, Czech Republic
821
P6.16.60 - Tonsils of patients with IgA nephropathy contain cells producing aberrantly glycosylated IgA1 and anti-glycan
antibodies: implications for tonsillectomy
Hitoshi Suzuki, Y. Suzuki, H. Yanagawa, Y. Makita, J. Novak, Y. Tomino;
Tokyo, Japan
822
P6.16.61 - Distribution of prostate specific antigen (PSA) among senegalese men with immunoenzymatic sandwich
method
Maguette D. Sylla Niang, B. Mbengue, N. Dramé, M. Jalloh, I. Labou, L. Niang, G. Woto Gaye, T.N. Dièye, S. Guèye, A. Dièye;
Dakar, Senegal
823
P6.16.62 - A Peptide based approach for the serological diagnosis of Chikungunya fever
Priyanka Verma, D.N. Rao;
New Delhi, India
824
P6.16.63 - Kinetics of expression of CD62L and CXCR3 on CD8+ T cells during treatment of hepatocellular carcinoma with
TACE
Yanjun Wang, J. Zheng, B. Sun, D. Liu, L. Yan;
Beijing, China
825
P6.16.64 - Cord blood graft composition and its impact on clinical outcome after allogeneic stem cell transplantation
Helena Wikell, J. Gertow, M. Uhlin, J. Mattsson;
Stockholm, Sweden
826
P6.16.65 - Characterising the effect of remote ischaemic preconditioning on the immune response in healthy volunteers
Jenni M. Williams, J. Pilcher, R. Beasley, A.C. La Flamme;
Wellington, New Zealand
827
P6.16.66 - Validation of in vitro human PBMC assay to determine Lymphocytes activation of new Biotherapeutics
Erika Zambello, E. Vicentini, F. Andreetta, F. Zanderigo, J. Chappell;
Verona, Italy
161
Posters - August 25
Panel N°
P1.07 EFFECTOR FUNCTIONS OF PHAGOCYTES
Session Time: Sunday, August 25, 13:20 - 15:00
001
P1.07.01 - Diverse role of Plasmodium falciparum haemozoin towards anti-malarial innate response
Selorme Adukpo, A.F. Feßer, T. Velavan;
Tubingen, Germany
002
P1.07.02 - Modulation of Moraxella catarrhalis and nontypeable Haemophilus influenzae phagocytosis by neuropeptides
NPY and CGRP
Daria Augustyniak, J. Nowak, A. Jankowski;
Wroclaw, Poland
003
P1.07.03 - Understanding innate immune functions of peripheral blood monocytes
Dominic H. Banda, K.C. Jambo, D.G. Russell, R.S. Heyderman, H.C. Mwandumba;
Blantyre, Malawi
004
P1.07.04 - Downregulation of dendritic cells functions by Neutrophil Extracellular Traps
Lorena S. Barrientos, V. Marin-Esteban, L. de Chaisemartin, C. Sandré, R. Gorges, C. Gueguen, L. Mascarell, S. Kerdine-Römer,
M. Pallardy, S. Chollet-Martin;
Chatenay-Malabry, France
005
P1.07.05 - Immunological prognosing of complications of locomotors trauma
Olga V. Berdugina, K.A. Berdugin;
Ekaterinburg, Russian Federation
006
P1.07.06 - Monocyte subsets and immunopathology in Leishmania braziliensis infection
R. Costa, S. Passos, E.M. Carvalho, Lucas P. Carvalho;
Salvador, Brazil
007
P1.07.07 - Modulation of Chitinases and CLPs during Macrophage Differentiation and Polarization
M. Di Rosa, Michelino Di Rosa, M. Malaguarnera, C. De Gregorio, G. Malaguarnera, L. Malaguarnera;
Catania, Italy
008
P1.07.09 - Effects of aging on phagocytic activity and nitric oxide production of peritoneal macrophages from elderly mice
in response to Candida albicans
Taiane P. Gardizani, K.H. Pinke, H.G. Lima, V.S. Lara;
Bauru, Brazil
009
P1.07.10 - Functional analyses and cytochemical staining of leucocytes from lumpsucker (Cyclopterus lumpus L.), including
IgM+ cells
Gyri T. Haugland, A. Rønneseth, K. Ulven, N. Vestvik, H.I. Wergeland;
Bergen, Norway
010
P1.07.11 - The differences in innate immune responses of Atlantic salmon, Atlantic cod and lumpsucker
Gyri T. Haugland, A. Rønneseth, H. Wergeland;
Bergen, Norway
011
P1.07.12 - The effects of anabolic steroids on dendritic cells
L.M. Cosgrave, E.W. Brenu, Teilah K. Huth, B. Gray, S.M. Marshall-Gradisnik;
Gold Coast, Australia
012
P1.07.13 - Inflammation driven functional differentiation of human macrophages in vitro
Paola Italiani, E.M.C. Mazza, S. Bicciato, C. Gemelli, A. Grande, I. Cifola, C.M. Battaglia, P. Giungato, D. Boraschi;
Pisa, Italy
013
P1.07.14 - Alveolar macrophage innate immune function in HIV-infected African adults
Kondwani C. Jambo, D.H. Banda, D.G. Russell, R.S. Heyderman, H.C. Mwandumba;
Blantyre, Malawi
014
P1.07.15 - The influence of T4 phage preparations on the activation of human monocytes in vitro
Grazyna Korczak-Kowalska, P. Wierzbicki, K. Bocian, D. Kłosowska, M. Zarzycki, J. Borysowski, M. Pacek, B. Weber-Dąbrowska,
A. Górski;
Warsaw, Poland
015
P1.07.16 - 12/15-lipoxygenase mediates GC-induced anti-inflammatory mechanisms in monocytes
Yvonne Kusche, L. Klotz, H. Wiendl, J. Roth, K. Barczyk;
Münster, Germany
016
P1.07.17 - Synthetic immunomodulatory peptides IDR-HH2, IDR-1002 and IDR-1018 regulate neutrophil functions
Francois Niyonsaba, L. Madera, K. Okumura, H. Ogawa, R.E.W. Hancock;
Tokyo, Japan
017
P1.07.18 - Role of Circadian Rhythm in cell metabolism and macrophage function
Jacqueline Oliva, B. Pineda Olvera, O. Rojas Espinosa, F. Sánchez García;
Mexico, Mexico
018
P1.07.19 - Respiratory Syncytial Virus Fusion protein stimulates neutrophil extracellular traps formation
Bárbara N. Porto, R.S. Czepielewski, A.P.D. Souza, C.B.C. Bonorino, R.T. Stein;
Porto Alegre, Brazil
019
P1.07.20 - An inactive chromatin configuration at the IL-10 locus in human neutrophils
Nicola Tamassia, M. Zimmermann, F. Bazzoni, G. Natoli, M.A. Cassatella;
Verona, Italy
162
Posters - August 25
020
P1.07.21 - Ouabain affects human monocyte activation and function
Mariana P.C. Teixeira, V.M. Rumjanek;
Rio de Janeiro, Brazil
021
P1.07.22 - Test-system for observing heat shock protein 70kDa (Hsp70) effect on reactive oxygen species production by
immune cells
Natalia Troyanova, R. Mirzoev, A. Sapozhnikov;
Moscow, Russian Federation
P1.08 DENDRITIC CELL SUBSETS
Session Time: Sunday, August 25, 13:20 - 15:00
022
P1.08.01 - Functional limitations of plasmacytoid dendritic cells limit type I interferon, T cell responses and virus control in
early life
Elodie Belnoue, P. Fontannaz, C. Tougne, A. Rochat, A. Bergthaler, P. Lambert, D. Pinschewer, C. Siegrist;
Geneva, Switzerland
023
P1.08.02 - The role of Dendritic Cells and Monocytes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
Ekua W. Brenu, T.K. Huth, S.K. Hardcastle, L. Cosgrave, D.R. Staines, S.M. Marshall-Gradisnik;
Gold Coast, Australia
024
P1.08.03 - Lag-3 expression and role in human plasmacytoid dendritic cells biology
C. Camisaschi, A. De Filippo, V. Beretta, F. Rini, M. Tazzari, F. Arienti, F. Triebel, L. Rivoltini, Chiara Castelli;
Milano, Italy
025
P1.08.04 - Distinct modulation of human myeloid and plasmacytoid dendritic cells by anandamide in multiple sclerosis
Valerio Chiurchiu, M. Cencioni, E. Bisicchia, M. De Bardi, C. Gasperini, G. Borsellino, D. Centonze, L. Battistini, M. Maccarrone;
Rome, Italy
026
P1.08.05 - NF-kB/RelA subunit plays the critical roles on the functions of plasmacytoid dendritic cells to thymus
Takahiro Doi, S. Mise, T. Fukazawa;
Tsukuba, Japan
027
P1.08.06 - Diminished Memory T-cell Expansion due to Delayed Kinetics of Antigen Expression by Lentivectors
Karina Furmanov, A. Hovav;
Jerusalem, Israel
028
P1.08.07 - Migratory behavior of dendritic cells during the development of lupus
María A. Gleisner, N. Crisóstomo, C. Fuentes, P. Reyes, M. Rosemblatt, M.R. Bono;
Santiago, Chile
029
P1.08.08 - Differentially activated respiratory plasmacytoid and CD11b-high dendritic cells accumulate during sublethal
Klebsiella pneumonia infection
Holger Hackstein, S. Kranz, A. Wachtendorf, G. Michel, J. Lohmeyer, G. Bein, N. Baal, S. Herold;
Giessen, Germany
030
P1.08.09 - Analysis of the characterization of bone marrow derived dendritic subsets
Kahoko Hashimoto, T. Kawasaki, T. Yamamoto, K. Takahashi, M. Kojima;
Narashino City, Chiba, Japan
031
P1.08.10 - Increased tubulointerstitial recruitment of human CD141hi CLEC9A+ and CD1c+ myeloid dendritic cells in fibrotic
kidney disease
Andrew J. Kassianos, X. Wang, S. Sampangi, K. Muczynski, H. Healy, R. Wilkinson;
Brisbane, Australia
032
P1.08.11 - Human dendritic cell subpopulations show distinct behavior in their interaction with the pathogenic mould
Aspergillus fumigatus
Jasmin Kungl, T. Breitschopf, S. Krappmann, H. Einsele, J. Loeffler;
Wuerzburg, Germany
033
P1.08.12 - CCR2+ monocyte-derived antigen-presenting cells from the genital tract promote Th1 and Th17 immunity after
HSV-2 infection
Su Hyun Lee, H. Yang, M. Kweon;
Seoul, Korea, Republic of
034
P1.08.13 - Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells
and is strongly induced by retinoic acid
Jérôme C. Martin, G. Bériou, M. Heslan, C. Chauvin, L. Utrianen, A. Aumenier, C. Scott, A. Mowat, V. Cerovic, S. Houston,
M. Leboeuf, F. Hubert, C. Hémont, M. Merad, S. Milling, R. Josien;
Nantes, France
035
P1.08.14 - Human 6-sulfo LacNAc+/CD16+ dendritic cells are distinct from Tie-2+ monocytes
Alessandra Micheletti, C. Costantini, F. Calzetti, W. Vermi, M.A. Cassatella;
Verona, Italy
036
P1.08.15 - Distinct subsets of dendritic cells regulate the outcome of colonic inflammation
A.R.B.M. Muzaki, Christiane Ruedl;
Singapore, Singapore
037
P1.08.16 - Analysis of the expression of the inhibitory receptor ILT4 on dendritic cells from systemic lupus erythematosus
(SLE) patients
Adriana E. Monsivais Urenda, P. Guerra de Blas, E. Zárate Hernández;
San Luis Potosí, Mexico
163
Posters - August 25
038
P1.08.17 - Human conventional CD1c+ Dendritic Cells produce IL-12 and induce potent CD8+ T cell priming
Giulia Nizzoli;
Milan, Italy
039
P1.08.18 - Tumor cell-derived Ag cross-presentation in human DC induced by NK cells: Mechanisms and specialization of
the BDCA-3+ DC subset
Vincent Ollion, F. Deauvieau, A. Doffin, E. Verronese, I. Durand, J. Marvel, H. Vie, C. Caux, J. Valladeau-Guilemond;
Lyon, France
040
P1.08.19 - IL-21 promotes plasmacytoid dendritic cell-NK cell cooperation through the production of granzyme B
Valentina Salvi, W. Vermi, A. Cavani, S. Lonardi, T. Carbone, P. Seeger, D. Bosisio, F. Facchetti, S. Sozzani;
Brescia, Italy
041
P1.08.20 - Intestinal Aldh1a2+CD103+CD8a+ DCs preferentially induce Th1 cells but not Tregs
Bo-Gie Yang, E. Lee, J. Kim, M. Jang, C. Hong, M. Song, A. Kumanogoh, Y. Sung, C.D. Surh, M. Jang;
Pohang, Korea, Republic of
042
P1.08.21 - Independence of ICOS-L expression on IL-10 production by DC and its impact on T cell subsets in respiratory tract
infection
Xiaoling Gao, J. Yang, X. Yang;
Winnipeg, Canada
P1.14 CYTOKINES AND OTHER REGULATORY MEDIATORS OF INFLAMMATION
Session Time: Sunday, August 25, 13:20 - 15:00
043
P1.14.01 - Can Serial Quantification of IL-1 in human peripheral blood predict Outcome of fracture healing?
Sabir Ali, A. Singh, A.A. Mehdi, R.N. Srivastava;
Lucknow, India
044
P1.14.02 - IL-1β, IL-6 and TNF-α gene’s expressions and receptor’s mutations in ovarian cancer tissues
Maha M. Arafah, M. Al-Mutairi, S. Al-Daihan, Y. Al-Anazi, M. Al-Anazi, M. Adar, A. Warsy, A. Warsy, M. Rouabhia, A. Semlali;
Riyadh, Saudi Arabia
045
P1.14.03 - Relationship between selenium intake and inflammatory markers in newly-diagnosed patients with
B-cell non-Hodgkin lymphoma
Mourad Aribi, M. Zahzeh;
Tlemcen, Algeria
046
P1.14.04 - Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of acute inflammation
Makoto Arita;
Tokyo, Japan
047
P1.14.05 - Fragmented but not integral collagen IV induces IL-10 in human monocytes
Lourdes Andrea Arriaga-Pizano, L. Martínez-Sánchez, I. Mancilla-Herrera, A. Jiménez-Uribe, C. López-Macías, A. Isibasi;
Mexico City, Mexico
048
P1.14.06 - Analysis of c reactive protein levels after an eccentric exercise
Victor Barros Costa;
Brasilia, Brazil
049
P1.14.07 - Immunomodulatory properties of bifidobacteria strains
Jirina Bartova, A. Salakova, J. Drbohlav, P. Roubal, O. Sveda, I. Lisová;
Prague, Czech Republic
050
P1.14.08 - Higher baseline tumor necrosis factor [TNF]-α and early postoperative interleukin [IL]-10 level are associated
with postoperative sepsis in cardiac surgery: A preliminary study
Mouna Ben Azaiz, R. Arbi, C. Romdhani, W. Ghothban, S. Haddad, I. Labbane, C. Kdous, S. Shnik, F. Mustapha, E. Ghazouani;
Tunis, Tunisia
051
P1.14.09 - Early diagnostics of the slowed down bone consolidation
Olga V. Berdugina, K.A. Berdugin;
Ekaterinburg, Russian Federation
052
P1.14.10 - Laboratory monitoring at hip arthroplasty
Olga V. Berdugina, K.A. Berdugin;
Ekaterinburg, Russian Federation
053
P1.14.11 - Effect of human recombinant interleukin-33 on collagen mRNA expression in lung fibroblasts
Alexander Bocharov, N. Filimonova, N. Sheveleva;
Kharkov, Ukraine
054
P1.14.12 - Pro and anti-inflammatory cytokines from periferal blood mononuclear cells in elderly
José Burgos, K.H. Pinke, B. Calzavara, P. Freitas-Faria, M.P.P. Nascimento, J. Venturini, V.S. Lara;
Bauru, Brazil
055
P1.14.13 - Acute inflammation and anemia: hepcidin and innate immunity
Maria Carrabba, M. Zarantonello, L. Duca, N. Campostrini, G. Fabio;
Milan, Italy
056
P1.14.14 - SNARE proteins in the synaptic secretion of IL-12 and in tumor-induced immunosuppression of dendritic cells
Giulia Chiaruttini, I. Soncin, P. Larghi, T. Galli, F. Benvenuti;
Trieste, Italy
164
Posters - August 25
057
P1.14.15 - EMF Exposure Facilitates Wound Healing Events Modulating Cytokines Expression
Erica Costantini, G. Vianale, C. D’Angelo, R. Muraro, M. Reale;
Chieti, Italy
058
P1.14.16 - Interleukin-1β micro-environment promotes viability and proliferation of malignant glioma cell U87MG
Nandakumar D Nanjaiah, H. Fathima K, P. Ramaswamy;
Bengaluru, India
059
P1.14.17 - Clinical relevance of Cytokines Gene Polymorphism (CGP) in recovery of hemorrhagic shock patients
Dablu L.G. D.L.G, D.N.R. D.N.Rao, S.K.B. Dr.Sanjeev;
New Delhi, India
060
P1.14.19 - Acute inflammation loci influence tissue repair in mice
T. Canhamero, M. Correa, J.G. Fernandes, A. Borrego, J.R. Jensen, W.H.K. Cabrera, O.G. Ribeiro, N. Starobinas, O.M. Ibañez,
Marcelo De Franco;
Sao Paulo, Brazil
061
P1.14.20 - Content of IL-15 in patients with myalgic encephalomyelitis / chronic fatigue syndrome
Nikolay Didkovski, I. Malashenkova, I. Zuykov, O. Gurskaya, J. Sarsania, G. Kazanova, N. Hailov, D. Ogurtzov;
Moscow, Russian Federation
062
P1.14.21 - Phagocytosis of apoptotic or necrotic cells differentially regulates the expression of IL-12 and IL-35 subunits
in human dendritic cells
Karen O. Dixon, J. O`Flynn, S. van der Kooij, C. van Kooten;
Leiden, Netherlands
063
P1.14.22 - Immunoproperties of hypothalamic proline-rich polypeptides for antibacaterial immune response
Andranik Durgaryan, M. Matevosyan, A. Galoyan;
Yerevan, Armenia
064
P1.14.23 - Targeting NO-driven Inflammation in Human Melanoma via IL-1s and CXCL-10
Suhendan Ekmekcioglu, K. Tanese, Y. Qin, E.A. Grimm;
Houston, United States
065
P1.14.24 - Interleukin 6 and interleukin 8 in maternal serum as markers of bacterial infection and preterm delivery
Želimir P. Eri , V. Jerant Pati , M. Bogavac, A. Pati ;
Banjaluka, Bosnia and Herzegovina
066
P1.14.25 - Constitutive STAT-3 activation with maintained responsiveness to IL-6 in peripheral lymphocytes of obese
women
D.H. Rhodes, V. Nguyen, M.E. Sullivan, S.L. Gomez, C. Braunschweig, Giamila Fantuzzi;
Chicago, United States
067
P1.14.26 - Evaluation of the immunological reactivity of blood cells in early pregnancy for predicting of pregnancy
outcomes
Irina Gazieva;
Yekaterinburg, Russian Federation
068
P1.14.27 - Cytokine’s concentrations and monocyte HLA DR expression as markers defining the therapeutic strategy in
contemporary behavior in patients with acute pancreatitis
Minkov Georgi, Y. Yovtchev, A. Petrov, S. Nikolov, T. Vlaykova, K. Halacheva;
Stara Zagora, Bulgaria
069
P1.14.28 - Macrophage migration inhibitory factor as a regulator of neonatal innate immune responses
Eric Giannoni, M. Weier, L. Guignard, F.C.G.J. Sweep, T. Calandra, T. Roger;
Lausanne, Switzerland
070
P1.14.29 - TNF-alpha, IL-4 and IL-10 cytokines induces changes in HO-1 and HDC expression in cervical cancer cells
Paulina Gomez-Lomeli, P.C. Ortiz-Lazareno, A. Bravo-Cuellar, G. Hernandez-Flores, J.R. Dominguez-Rodriguez, L.F. Jave-Suarez,
A. Aguilar-Lemarroy;
Guadalajara, Mexico
071
P1.14.30 - To study the contribution of activated CD4+ and CD8+T cells arisen from B-T constructs of F1 and V antigens
of Yersinia pestis for the antibacterial activity as an improved vaccine
Geetanjali Gupta, D. Rao;
Jodhpur, India
072
P1.14.31 - Resiniferatoxin exhibits anti-inflammatory property by inhibits pro-inflammatory mediators in endotoxin-challenged
mice
Oscar Gutierrez-Coronado, J. Viveros-Paredes, M. Miranda-Beltran, M. Perez-Vega, C. Soria-Fregozo, P. Villalobos Gutierrez;
Lagos de Moreno, Mexico
073
P1.14.32 - Biomarkers of cardiovascular risk in psychiatric disorders
Angelos Halaris;
Maywood, United States
074
P1.14.33 - miRNAs in Sera of Tunisian Patients discriminate between inflammatory Breast Cancer and non-inflammatory
Breast Cancer
K. Hamdi, D. Goerlitz, M. Islam, B. Neili, F. Ben ayed, S. Chivi, C. Loffredo, I. Jilson, A. Benammar Elgaaied, J. Blancato, R. Marrakchi,
Raja Triki;
Tunis, Tunisia
075
P1.14.34 - Identification, function and mechanism of novel potential cytokines and membrane molecules of immune cells
Wenling Han, P. Wang, D. Ma;
Beijing, China
165
Posters - August 25
076
P1.14.35 - The effect of type I and III interferons on the adrenal cortex in the context of autoimmune Addison’s disease
Alexander Hellesen, L. Breivik, K. Edvardsen, E. Husebye, E. Bratland;
Bergen, Norway
077
P1.14.36 - Immune Senescence in an Innate Immunity Drosophila model
Ana M. Hernandez, M. Tatar;
Providence, United States
078
P1.14.37 - Inverse susceptibility to liver and lung carcinogenesis in mouse lines genetically selected for acute inflammatory
response
L.R. Carvalho, W.H.K. Cabrera, A. Borrego, A.M. Santos, O.G. Ribeiro, J.R. Jensen, N. Starobinas, M. De Franco, Olga M. Ibañez;
São Paulo, Brazil
079
P1.14.38 - Platelet-activating factor enhances tumor metastasis via the reactive oxygen species-dependent protein kinase
CK2-mediated NF-kB activation
Suhn-Young Im, K. Kim, K. Cho, H. Kim, H. Lee, K. Jang, H. Kim;
Gwangju, Korea, Republic of
080
P1.14.39 - Pathophysiological roles of the CX3CL1-CX3CR1 axis in chemical-induced skin carcinogenesis
Yuko Ishida, M. Nosaka, A. Kimura, Y. Kuninaka, M. Kawaguchi, N. Mukaida, T. Kondo;
Wakayama, Japan
081
P1.14.40 - Inflammatory and cytotoxic effect of silver nanoparticles on human endothelial cells
Jiyoung Jang, I. Choi;
Seoul, Korea, Republic of
082
P1.14.41 - Involvement of collagen receptor DDR2 in cytokine production by dendritic cells
Dae-Ki Kim, B. Poudel, Y. Lee;
Jeonju-city, Korea, Republic of
083
P1.14.42 - The prenylated flavonoids and 2-arylbenzofurans from the root barks of Morus alba inhibit airway inflammation
Hyun Pyo Kim, H. Lim, J. Lee, H. Jin, E. Woo, S. Lee;
Chunchon, Korea, Republic of
084
P1.14.43 - Dynamic cross-talk model of innate immune response to double-stranded RNA: order emerging from noisy cell
responses
R. Bertolusso, B. Tian, Y. Zhao, L. Vergara, A. Sabree, M. Iwanaszko, T. Lipniacki, A.R. Brasier, Marek Kimmel;
Houston, United States
085
P1.14.44 - Interleukin-33 promotes proliferation of primary human lung fibroblasts
A. Bocharov, Olga Kornilova;
Kharkov, Ukraine
086
P1.14.45 - Features of the allergic drug reactions in Russian patients: perspectives of a DNA bank development
Ilya Kukes, T. Borisova;
Moscow, Russian Federation
087
P1.14.46 - HMGB1 in an experimental model of acute lung injury
Cilmery S. Kurokawa, J.R. Fioretto, J.P. Araújo Junior, R.B. Pires, M.A. Moraes, R.C. Bonatto, M.F. Carpi;
Botucatu, Brazil
088
P1.14.47 - Prone positioning attenuates TNF-alpha production in rabbits with lung injury under protective conventional
mechanical ventilation (CMV).
Cilmery S. Kurokawa, R.B. Pires, J.R. Fioretto, S.O. Klefens, J.P. Araújo, M.A. Moraes, A.M. Lousada, R.C. Bonatto, M.F. Carpi;
Botucatu, Brazil
089
P1.14.48 - A potential role for the X chromosome in the CD99 expression and proinflammatory cytokine secretion in
response to TLR ligands
Nicolas Lefèvre, F. Corazza, J. Duchâteau, A. Delbaere, G. Casimir;
Brussels, Belgium
090
P1.14.49 - Study of immunosenescence through the production of cytokines by blood monocytes
Heliton G. Lima, P. Freitas-Faria, K.H. Pinke, M.P.P. Nascimento, N.A. Vieira, V.C. Porto, V.S. Lara;
Bauru, Brazil
091
P1.14.50 - Roles of IL-22 in the innate immune of chronic hepatitis B
Y. Zheng, Zipei Liu, M. Li, J. Zhang, Q. Jing, K. Feng, J. Zhang;
Beijing, China
092
P1.14.51 - TNF, autoantibodies and soluble receptors to TNF in health and rheumatoid arthritis
Julia A. Lopatnikova, E.A. Golikova, N.S. Shkaruba, A.E. Sizikov, S.V. Sennikov;
Novosibirsk, Russian Federation
093
P1.14.52 - Markers of cellular damage, inflammation and apoptosis in a model of endotoxic shock
J. Martinez Castillo, D. Cid Guerrero, I. Vargas Rodriguez, S.H. Sanchez Rodriguez, R.M. Ramirez Santoyo, G.G. Guerrero M,
Erendira E. Lopez Robles;
Zacatecas, Mexico
094
P1.14.53 - Human acidic mammalian chitinase (AMCase); molecular cloning, protein expression, and production of
monoclonal antibody
Kanokwan Lowhalidanon, P. Meekrathok, S. Thongsom, W. Suginta, P. Khunkaewla;
NakhonRatchasima, Thailand
095
P1.14.54 - CTRP4 Plays an Important Role in Endotoxin Shock
Yang Luo, W. Tan, Z. Ma, L. Wang, D. Na, X. Wu, Y. Chen, Y. Zhang, D. Ma, L. Wang;
Beijing, China
166
Posters - August 25
096
P1.14.55 - Endothelial cells enhances chemokines and reduces inflammatory cytokines release by human monocyte in
vitro
Ismael Mancilla-Herrera, J. Alvarado-Moreno, S. Estrada-Parra, C. López-Macías, A. Isibasi, L. Arriaga-Pizano;
Mexico City, Mexico
097
P1.14.56 - Pro-inflammatory cytokines analysis in HPV-positive cancer cells
Giorgio Mangino, S.M. Zangrillo, V.M. Chiantore, M. Iuliano, M. Severa, G. Fiorucci, E.M. Coccia, G. Romeo;
Latina, Italy
098
P1.14.57 - IL-6, IL-6sr, TNF-α, IL-10 and IL-8 levels in patients with chronic periodontitis after periodontal therapy
Patrizzia Mastromatteo-Alberga, M. Correnti, L. Escalona;
Caracas, Venezuela, Bolivarian Republic of
099
P1.14.58 - Deficiency of IL-10/IL-12 cytokine exacerbate systemic inflammatory responses in renal injury induced by
ischemia and reperfusion
Vanessa Nunes de Paiva, R. M. M. Monteiro, R. Assumpção Larocca, P. Semedo, M. A. dos Reis, A. Pacheco-Silva, N. O. S. Câmara;
Sao Paulo, Brazil
100
P1.14.59 - HMG-CoA reductase inhibitor simvastatin improves organ dysfunction, inflammatory profile, bacterial clearance
and cognitive damage after onset of sepsis
Flora M.J. Oliveira, C.F. Gonçalves-de-Albuquerque, I.M. Medeiros-de-Moraes, P.A. Reis, P.T. Bozza, F.A. Bozza, A.R. Silva, H.C. CastroFaria-Neto;
Rio de Janeiro, Brazil
101
P1.14.60 - Human mesenchymal stem cell adherence and invasivity in vitro after transfection with CD29 specific siRNA
Carmen Panaitescu, L. Marusciac, F. Bojin, V. Paunescu;
Timisoara, Romania
102
P1.14.61 - In vitro effect of Interleukin-33 on gastric adenocarcinoma cell line (AGS) and intestinal epithelial cancer cell line
(Caco-2)
Laura F. Pisani, L. Pastorelli, N. Munizio, M. Vecchi;
Milan, Italy
103
P1.14.62 - In silico design of cytokine-trap peptides for modulation of the IL-13 signalling pathway in asthma
Nicola J. Purdy, W. Walker, J.G.L. Mullins;
Swansea, United Kingdom
104
P1.14.63 - Chemokines and biomarkers of endothelial dysfunction in chronic urticaria
Ilaria Puxeddu, F. Panza, F. Pratesi, D. Bartaloni, V. Rocchi, I. Del Corso, P. Migliorini;
Pisa, Italy
105
P1.14.64 - Role of Cytokine Response in Disease Progression and Severe Clinical Outcomes in Leptospirosis
E.A.G. Reis, J. Hagan, G.S. Ribeiro, A.T. Carvalho, O.A. Martins-Filho, R.R. Montgomery, A.C. Shaw, A.I. Ko, Mitermayer G. Reis;
Salvador/Ba- Brazil, Brazil
106
P1.14.65 - IL-33 signaling modulates the development of adriamycin-nephropathy
Vanessa O. Reis, J. Nogueira-Neto, B.C. Vivanco, A.C. Keller;
São Paulo, Brazil
107
P1.14.67 - Nitric Oxide tightly regulates Dendritic Cells life cycle and cytokines release under inflammatory conditions
Chiara Ripamonti, S. Baldassarri, C. Storini, D. Miglietta, M. Foti;
Milano, Italy
108
P1.14.68 - Correlation of magnesium levels with inflammatory markers in thiazide induced hypomagnesemic rats
Sarah Sadiq, A. Naveed, T. Ahmed, S. Khan;
Islamabad, Pakistan
109
P1.14.69 - Anti-inflammatory, immunostimulatory and antiviral effects of Coffee fruit (Coffea arabica)
Fátima B. Saldaña Morales, I.A. Lozada Requena, D.F. Zegarra Ruiz, S.R. Dávila Paico, M.A. Cabello Napuri, J.L. Aguilar Olano;
Lima, Peru
110
P1.14.70 - Proinflammatory Effect of the P2X7 Receptor during Sepsis
Patricia T. Santana, C.F. Benjamim, C. Takiya, C. Caruso-Neves, R. Coutinho-Silva;
Rio de Janeiro, Brazil
111
P1.14.71 - Role and correlation of inflammatory cytokines, angiogenic markers and insulin growth factors in
post treatment (neoadjuvant chemoradiation) disease mapping in advanced stage carcinoma of uterine cervix
Manoj Sharma, R. Khan, M. Aggarwal, A. Sharma;
New Delhi, India
112
P1.14.72 - S100A8 and S100A9 induce the expression of cytokines and regulate the NLRP-3 inflammasome via
ROS-dependent activation of NF-κB
Jean-Christophe C. Simard, A. Cesaro, M. Tardif, F. Antoine, P.A. Tessier, D. Girard;
laval, Canada
113
P1.14.73 - Mice selected for maximal inflammatory response display a higher lung inflammation induced by Tityus
serrulatus scorpion venom
P.G. Lara, T.R. Narcizo, A.F. Machado, V.D. Aiello, L.A. Benvenuti, F.C.V. Portaro, O.A. Sant Anna, N. Starobinas, O.G. Ribeiro, Monica
Spadafora-Ferreira;
São Paulo, Brazil
114
P1.14.74 - Melaleuca alternifolia and its main component, terpinen-4-ol, inhibit the production of IL-1β, IL-6, IL-4 and IL-10
by activated monocytes
Denise P. Spolidorio, M.N. Nogueira, T. Bedran, M.F. Correia, L. Barbosa, C. Rossa Junior;
Araraquara, Brazil
167
Posters - August 25
115
P1.14.75 - Inflammatory responses to low volume high load and high volume medium load protocols during dynamic leg
press exercise
Johanna K. Stenholm, S. Walker, G. Paulsen, K. Häkkinen, W.J. Kraemer, M. Hämäläinen, K. Vuolteenaho, E. Moilanen, A.A. Mero;
Jyväskylä, Finland
116
P1.14.76 - Cytokines profile in a social defeat animal model of depression and effects of a novel anti-asthenic drug ladasten
Anna V. Tallerova, L. Kovalenko, O. Kuznetsova, A. Durnev, S. Seredenin;
Moscow, Russian Federation
117
P1.14.77 - sICAM-1 and sUPAR as Immune Markers for Treatment Response in Ethiopian TB-Patients with and without HIV
Co-Infection
Wegene Tamene, D. Kassa, Y. Alemayehu, G. Gebremicheal, A. Alemu, T. Messele;
Addis Ababa, Ethiopia
118
P1.14.78 - State of adaptive mucosal immunity among immunocompromised patients with allergic rhinosinusitis
Nataly Tataurshchikova;
Moscow, Russian Federation
119
P1.14.79 - High sensitivity C-reactive protein and insulin levels in obese and non-obese patients with polycystic ovarian syndrome
Sadaf S. Uppal, A. Naveed, A. Majeed;
Islamabad, Pakistan
120
P1.14.80 - HMGB1 is a major mediator of pathology in mice surviving sepsis
Sergio I. Valdes-Ferrer, M. Rosas-Ballina, B. Lu, P.S. Olofsson, J. Roth, D.J. Antoine, U. Andersson, K.J. Tracey;
Manhasset, United States
121
P1.14.81 - Association of polymorphism of TNF-alpha receptors genes with expression levels of membrane-bound
receptors and serum levels of soluble receptors
Filipp F. Vasilyev, S.V. Sennikov, J.A. Lopatnikova, A.N. Silkov;
Novosibirsk, Russian Federation
122
P1.14.82 - Comparison of cytokine production in human lymphocytes and human tissue culture THP 1 stimulated by metallic ions
Zora Venclikova, J. Bartova, J. Belacek;
Prague, Czech Republic
123
P1.14.83 - TNF and IL-10 in a bitter-sweet battle in taste buds
P. Feng, J. Chai, L. Huang, Hong Wang;
Philadelphia, United States
124
P1.14.84 - The role of Notch signaling in IL-12 production in murine macrophages
Wipawee Wongchana, B.A. Osborne, N. Boonyatecha, N. Sangphech, T. Palaga;
Bangkok, Thailand
125
P1.14.85 - Cortex Magnolia Officinalis extract prevents gastric ulcer by stimulating CB2 gene expression and reducing IL-6
and TNF-alpha productions in stomach tissue
Mei-Li Wu, H. Chaung, M. Hsieh, C. Chen, H. Chiu;
Pingtung, Taiwan
126
P1.14.86 - An essential role for eosinophils in neutrophil accumulation in response to eotaxin
Pedro P. Xavier-Elsas, R.A. Luz, L.C.G. Arcanjo, A.C. Faria, M.C. Gaspar-Elsas;
Rio de Janeiro, Brazil
127
P1.14.87 - Interleukin-1 signaling prevents bacteremia in enteric infection with Citrobacter rodentium
H. Yang, Mi-Na Kweon;
Seoul, Korea, Republic of
128
P1.14.88 - IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages
Y. Sato, H. Hara, S. Suzuki, T. Kaisho, Hiroki Yoshida;
Saga, Japan
P1.16 COMPLEMENT SYSTEM
Session Time: Sunday, August 25, 13:20 - 15:00
129
P1.16.01 - Transcript levels of complement regulatory proteins (CD35 and CD59) in rheumatoid arthritis patients and their
relationship with disease activity and prognosis
Devyani Anand, U. Kumar, M. Kanjilal, S. Kaur, N. Das;
New Delhi, India
130
P1.16.02 - Anti-mitochondria antibodies type 2 and neurological manifestations: Report of 5 cases
Imen Ayadi, L. Laadhar, M. Kallel Sellami;
Tunis, Tunisia
131
P1.16.03 - Immunotoxicity of work environment exposure in some welders: implications for occupational health
Bosun Banjoko;
Ile-Ife, Nigeria
132
P1.16.04 - Hereditary C1 esterase inhibitor deficiency in Tunisia: a seven years laboratory experience
Ahlem Ben Hmid, H. Jouini, Y. Zerzeri, J. Sassi, L. Laadhar, M. Sallemi, S. Makni;
Tunis, Tunisia
133
P1.16.05 - Humoral Immunity in the healthy population of the central region of Cuba
L.C. Bequer Mendoza, T. Gómez Hernández, L. Salazar Torres, L. Perez de Alejo Rodriguez, V. Hernández Moreno, L. Molina Hernández,
Oliver Perez;
Santa Clara. Villa Clara, Cuba
168
Posters - August 25
134
P1.16.06 - Whole exome sequencing in a Finnish family with hereditary angioedema with normal C1 inhibitor
Laura J. Bouchard, H. Jarva, A. Laukkanen, M.J. Savolainen, S. Meri;
Helsinki, Finland
135
P1.16.07 - Effect of immune complex and cytokines on expression and modulation of neutrophil complement regulatory proteins
in SLE
Nibhriti Das, B. Biswas, U. Kumar, V. Arora, A. Kumar;
New Delhi, India
136
P1.16.08 - Contribution of C5a measurement to explain some clinical biological discrepancies in monitoring of lupus
Kamel Djenouhat, A. Tahiat, M. Boucelma;
Algiers, Algeria
137
P1.16.09 - Complement activation in patients with systemic lupus erythematosus without nephritis
A. Tahiat, Kamel Djenouhat, M. Boucelma, M.C. Abbadi;
Algiers, Algeria
138
P1.16.10 - MASP2 and MBL: Dynamics and Intrathecal synthesis
Alberto J. Dorta-Contreras, B. Padilla Docal, A. Arias Morales, O. Pérez, H. Reiber, J.C. Jensenius;
Havana, Cuba
139
P1.16.11 - Human skin-derived mast cells express complement C3 and C5
Yoshihiro Fukuoka, M. Hite, A. Dellinger, L.B. Schwartz;
Richmond, United States
140
P1.16.12 - Probiotic spores: a missing link between innate immunity and nutritional health
E. Saball, M. Salvarrey, J. Moreno, N. Abraham, Roberto R. Grau;
Rosario, Argentina
141
P1.16.13 - Hereditary complement C8 deficiency in a Turkish family found in a girl with recurrent meningitis and
her asymptomatic sister
Nesrin Gulez, F. Genel, L. Skattum, L. Truedsson;
Izmir, Turkey
142
P1.16.14 - Complement component C3 variant (R102G) and the risk of neovascular age realated macular degeneration
in a Tunisian population
Imen Habibi, I. Sfar, A. Chebil, F. kort, R. Bouraoui, R. Limaiem, S. Ayed, T. Ben Abdallah, L. El Matri, Y. Gorgi;
Tunis, Tunisia
143
P1.16.15 - The Yersinia pestis Outer Membrane Protein Ail Recruits C4b-Binding Protein Leading to Factor I-Mediated
Inactivation of Covalently and Non-covalently Bound C4b
Derek K. Ho, M. Skurnik, A. Blom, S. Meri;
Helsinki, Finland
144
P1.16.16 - Neutralizing complement resistance improves cell-mediated killing (CDCC) of HER2 positive breast cancer cells
by Trastuzumab and Pertuzumab
S. Mamidi, S. Höne, Michael Kirschfink;
Heidelberg, Germany
145
P1.16.17 - Dissecting the modular nature of properdin using recombinant thrombospondin repeats TSR4 and TSR5
Lubna Kouser, M. Abdul-Aziz, R.B. Sim, A.G. Tsolaki, U. Kishore;
London, United Kingdom
146
P1.16.18 - Comparison of C3 and C4 with CH50 in North West of Iran
Behzad Mansoori, A. Osali;
Tabriz, Iran, Islamic Republic of
147
P1.16.19 - Myeloperoxidase directly interacts with properdin and induces alternative pathway complement activation
Joseph O`Flynn, K. Dixon, M.C. Faber Krol, M.R. Daha, C. van Kooten;
Leiden, Netherlands
148
P1.16.20 - Marine algae Bostrychia tenella fractions and extracts from associated endophytic microorganisms modulate
the complement system
J.C. Pereira, C.G. Nogueira-Santos, T.M.C. Ogasawara, R. de Felício, H.M. Debonsi, Luciana S. Pereira-Crott;
Ribeirão Preto, Brazil
149
P1.16.21 - Developmental programming of low levels of C3 and C4 complement factors by gestational chronodisruption
Jose M. Sarmiento, N. Mendez, H. Galdames, C. Spichiger, M. Seron-Ferre, H. Folch, C. Torres-Farfan, H. Richter;
Valdivia, Chile
150
P1.16.22 - Dietary restriction and fasting downregulate complement activity via MBL-pathway
Shushimita Shushimita, P. van der Pol, R. W. F. de Bruin, J. N. M. IJzermans, C. van Kooten, F. J. M. F. Dor;
Rotterdam, Netherlands
P2.06 LEUKOCYTE TRAFFICKING
Session Time: Sunday, August 25, 13:20 - 15:00
151
P2.06.01 - CCL17 deficiency is associated with beneficial CNS immune responses and prevents cognitive decline in a
mouse model of Alzheimer’s disease
K. Neitzert, Ö. Albayram, R. Göhrs, I. Karaca, A. Ramirez, J. Walter, F. Jessen, W. Maier, A. Zimmer, Judith Alferink;
Bonn, Germany
169
Posters - August 25
152
P2.06.02 - T-cell immunoglobulin- and mucin-domain-containing molecule (Tim)-1 is a novel physiological ligand
for P-selectin controlling activated T cell trafficking under inflammatory conditions
Stefano Angiari, T. Donnarumma, B. Rossi, G. Piacentino, S. Dusi, S. Xiao, V.K. Kuchroo, P.D. Rennert, G. Constantin;
Verona, Italy
153
P2.06.03 - Expression and function of selectins during human development in utero
Kaisa Auvinen, S. Jalkanen, M. Salmi;
Turku, Finland
154
P2.06.04 - Susceptibility of Mycobacterium tuberculosis-infected CCR4 deficient mice is associated with a balance between
lymphocytes and Foxp3+ regulatory cells
Thaís B. Bertolini, A.R. Piñeros, R.Q. Prado, A.F. Gembre, J.C. Alves Filho, V.L. Bonato;
Ribeirão Preto, Brazil
155
P2.06.05 - Pivotal role of Ccr1 in murine lupus nephritis
Alexandre Bignon, F. Gaudin, P. Hémon, H. Tharinger, P. Loetscher, M. Peuchmaur, D. Berrebi, K. Balabanian;
Clamart, France
156
P2.06.06 - Local and systemic effects of chronic peritonitis induced by pristane in the absence of galectin-3
Camila Brand, F.L. Oliveira, T.P. Costa, F.E.P.L. Abreu, R. Borojevic, R. Chammas, M.C. El-Cheikh;
Rio de Janeiro, Brazil
157
P2.06.07 - CCR5-dependent T cell migration contribute to squamous cell carcinoma development
C.E. Oliveira, T.H. Gasparoto, C.R. Pinheiro, K.A. Cavassani, G.P. Garlet, J.S. Silva, Ana P. Campanelli;
Bauru, Brazil
158
P2.06.08 - The absence of chemokine signalling via CCR5 impairs sepsis outcome
Fernanda V.S. Castanheira, F. Sonego, A. Kanashiro, P.G. Czaikoski, T.M. Cunha, J. Alves-Filho, F.Q. Cunha;
Ribeirão Preto, Brazil
159
P2.06.09 - Melatonin regulates the migration of granulocytes into mouse peritoneal cavity via MT2 receptor
Vitalij Cernysiov, M. Mauricas, I. Girkontaite;
Vilnius, Lithuania
160
P2.06.10 - CLEVER-1 as a cell trafficking molecule
Johannes Dunkel, P. Rantakari, M. Karikoski, O. Schulz, O. Pabst, S. Jalkanen;
Turku, Finland
161
P2.06.12 - Phenotypic characterization of CLEVER-1 knock-out mice
Kati Elima, M. Karikoski, P. Rantakari, M. Salmi, S. Jalkanen;
Turku, Finland
162
P2.06.13 - Studies on the human primary amine oxidase/sialic acid binding Ig-like lectin -9 and -10 interactions
Heli Elovaara, V. Parkash, R. Fair-Mäkelä, E. Bligt-Lindén, T.A. Salminen, S. Jalkanen;
Turku, Finland
163
P2.06.14 - A novel role for GIRK channels in the immune system
Erez S. Garty, A. Kaminitz, A. Ben-Nun, E. Reuveny;
Rehovot, Israel
164
P2.06.15 - Integrin alpha 4 differentially affect the homing of effector and regulatory T cell subsets
Simon Glatigny, R. Duhen, C. Arbelaez, S. Kumari, M. Oukka, E. Bettelli;
Seattle, United States
165
P2.06.16 - Contribution of L-selectin to activated CD4 and CD8 T cell migration into dermal inflammation
Thomas B. Issekutz;
Halifax, Canada
166
P2.06.17 - Podoplanin (Aggrus)-bound CCL21 regulates adhesive migration of T lymphocytes on the cell surfaces
of lymphatic endothelium
Caname Iwata;
Tokyo, Japan
167
P2.06.18 - TCR-Induced Activation of LFA-1 Involves Signaling through Tiam1
Farhana A. Jahan, M. Grönholm, C.G. Gahmberg;
Helsinki, Finland
168
P2.06.19 - 17-parameter flow cytometry: immunophenotyping cellular infiltration during flavivirus encephalitis in the mouse
T.M. Ashhurst, C. van Vreden, M. Karimi Azardaryany, K. Lundsten, S. Allen, S. Dervish, F. Kao, A. Smith, Nicholas Jonathan Cole
King;
Sydney, Australia
169
P2.06.20 - CD69 expression and leukocyte distribution in CD69-BAC transgenic mice
Teresa Laguna, L. Notario, P. Lauzurica;
Majadahonda, Spain
170
P2.06.21 - Induction of cytosolic phospholipase A2α is required for adipose neutrophil infiltration and hepatic insulin
resistance early in the course of high fat feeding
Rachel Levy, N. Hadad, O. Burgazliev, V. Elgazar carmon, A. Rudich;
beer-Sheva, Israel
171
P2.06.22 - Deficiency of the leukocyte integrin inhibitor, Del-1 exacerbates experimental autoimmune encephalomyelitis
through increased Th17 cells infiltration
Jong-Hyung Lim;
Dresden, Germany
170
Posters - August 25
172
P2.06.23 - Possible role of Myo1g in vesicular traffic of different molecules of B lymphocytes
Orestes López-Ortega, J. Maravillas-Montero, G. Patiño-López, S. Shaw, L. Santos-Argumedo;
México DF, Mexico
173
P2.06.24 - AChR-specific T cell trafficking in the thymus of chronic Experimental Autoimmune Myasthenia Gravis
Roberta Marolda, C. Cordiglieri, P. Cavalcante, P. Bernasconi, R. Mantegazza, F. Baggi;
Milan, Italy
174
P2.06.25 - Role of CD38 in regulating the migration of B cells in Chronic Lymphocytic Leukemia
Silvia Mele, S. Devereux, A. Ridley;
London, United Kingdom
175
P2.06.26 - The autotaxin/lysophosphatidic acid is a regulator of lymphocyte extravasation at the high endothelial venules
of lymph nodes
Masayuki Miyasaka, E. Umemoto, A. Takeda, Z. Bai, L. Cai, E. Hata, K. Tohya, Y. Komai, P. Veeraveedu, Y. Sugiura;
Suita, Japan
176
P2.06.27 - Langerhans cell penetration through the epidermal- dermal barrier
Christine Moussion, M. Sixt;
Klosterneuburg, Austria
177
P2.06.28 - Identification and Characterization of a Monocyte CXCL4 Receptor
J.M. Fox, F. Kausar, A. Day, M. Osbourne, A. Mueller, T. Tsuchiya, S. Kanegasaki, James E. Pease;
London, United Kingdom
178
P2.06.29 - Involvement of CXCR3 and CXCR4 in natural killer cell trafficking into bone marrow during multiple myeloma
growth
Andrea Ponzetta, G. Benigni, F. Antonangeli, G. Sciumè, G. Bernardini, A. Santoni;
Rome, Italy
179
P2.06.30 - Natural posttranslational modification of CXC chemokines modifies their in vitro and in vivo activity
Paul Proost, A. Mortier, E. Moelants, T. Loos, M. Gouwy, S. Struyf, G. Opdenakker, J. Van Damme;
Leuven, Belgium
180
P2.06.31 - Non-hematopoietic endothelial LSP1 orchestrates CXCL2-sensitive motile neutrophil functions in vivo
Syed M. Qadri, M. Hossain, N. Xu, L. Liu;
Saskatoon, Canada
181
P2.06.32 - Sphingosine-1-phosfate receptors are involved in cell migration in T-cell acute lymphoblastic leukemia
and lymphoma
Carolina V.M. Rachid, J.P. Lemos, W. Savino, D.A. Mendes-da-Cruz;
Rio de Janeiro, Brazil
182
P2.06.33 - A new mTOR-dependent, Akt-independent pathway differentiates the migratory behavior of regulatory
and conventional T cells
Giorgio Raimondi, L.C. Chen, B.R. Rosborough, A.W. Thomson;
Baltimore, United States
183
P2.06.34 - Role of oxysterol EBI2 ligand pathway in inflammation
Andrea Reboldi, T. Yi, J.G. Cyster;
San Francisco, United States
184
P2.06.35 - CR3 and CR4 differently mediate the adherence to fibrinogen of human dendritic cells
Noémi Sándor, C. Kriston, A. Erdei, Z. Bajtay;
Budapest, Hungary
185
P2.06.36 - Angiotensin II-induced vascular dysfunction depends on aortic infiltration and mutual activation of NK cells
and monocytes
Melanie Schwenk, S. Kossmann, M. Hausding, M. Knorr, M.I. Schmidgen, S.H. Karbach, A. Daiber, T. Münzel, P. Wenzel, C. Becker;
Mainz, Germany
186
P2.06.37 - Morphometric analysis of the distribution of decidua NK cells and macrophages in the neighborhood
of the trophoblast invasion front
Peter Sedlmayr;
Graz, Austria
187
P2.06.38 - Endothelial- specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo
Ruth Seelige, C. Natsch, S. März, D. Jing, M. Frye, S. Butz, D. Vestweber;
Muenster, Germany
188
P2.06.39 - PI3Kgamma confers resistance against Trypanosoma cruzi infection due to its important role in microbicidal
activity of macrophages
Maria C. Silva, R. Sesti, F.C. Dias, T.S. Medina, G.K. Silva, J.C.A. Filho, F.Q. Cunha, J.S. Silva, T.M. Cunha;
Ribeirão Preto, Brazil
189
P2.06.40 - Nr4a1-dependent Ly6Clow monocytes monitor endothelial cells and orchestrate their disposal in the presence
of nucleic acids
L.M. Carlin, Efstathios Stamatiades, C. Auffray, R.N. Hanna, L. Glover, G. Vizcay-Barrena, C.C. Hedrick, H.T. Cook, S. Diebold,
F. Geissmann;
London, United Kingdom
190
P2.06.41 - Simultaneous analysis of multiple fluorescent proteins and fluorochromes by a novel spectral flow cytomete
Micho Tomura, K. Futamura, M. Furuki;
Kyoto-city, Japan
171
Posters - August 25
191
P2.06.42 - The atypical chemokine receptor D6 is mobilized from recycling endosome for adaptive up-regulation and
chemokine degradation through a β-arrestin1/myosinVb-dependent mechanism
Alessandro Vacchini, E.M. Borroni, C. Cancellieri, A. Mantovani, M. Locati, R. Bonecchi;
Rozzano, Italy
192
P2.06.43 - LFA-1 is critical for T-cell mediated protective immunity elicited by heterologous prime-boost vaccination strategy
against a systemic parasitic infection
F. Virgilio, M. Mariana R. Dominguez, A. V. Machado, O. Bruna–Romero, R. Ricardo T. Gazzinelli, M. M. Rodrigues,
José Ronnie C. Vasconcelos;
São Paulo, Brazil
193
P2.06.44 - TNFR2 induces IRF-1 dependent IFNβ autocrine signaling in endothelial cells to promote monocyte recruitment
Deepak Venkatesh, T. Ernandez, F. Rosetti, I. Batal, X. Cullere, F. Luscinskas, Y. Zhang, G. Stavraki, G. García-Cardeña, B. Horwitz,
T. N Mayadas;
Boston, United States
194
P2.06.45 - Role of CBAP in chemokine-induced zap70-mediated T-cell trafficking
Y. Chiang, K. Ho, K. Ho, C. Sun, J. Chiu, F. Lee, F. Liao, H. Yang-Yen, Jeffrey J. Yen;
Taipei, Taiwan
P2.09 MHC AND OTHER POLYMORPHIC GENES IN HEALTH AND DISEASE
Session Time: Sunday, August 25, 13:20 - 15:00
195
P2.09.01 - New genetic variants of the CCR5 gene in the Omani population
Ali A. Al-Jabri, S.H. Al-Mahroqi;
Muscat, Oman
196
P2.09.03 - Possible involvement of polymorphisms in OAS2, OAS3, and CD209 genes, associated with severe forms
of tick-borne encephalitis, in predisposition to hepatitis C in Russian population
Andrey Barkhash, G. Kochneva, E. Chub, S. Mikhaikova, A. Romaschenko;
Novosibirsk, Russian Federation
197
P2.09.04 - Role of paired immunoglobulin-like receptor B (PirB) and T CD8 lymphocytes during axonal regeneration following
peripheral axotomy
André L. Bombeiro, S.L.O. Nunes, B.M. Moreira, A.L.R. Oliveira;
Campinas, Brazil
198
P2.09.05 - Possible roles of MICA and NKG2D and their interaction in the pathogenesis of autoimmune Addison’s disease
Eirik Bratland, A. Hellesen, K. Edvardsen, E.S. Husebye;
Bergen, Norway
199
P2.09.06 - Cross-presentation in renal transplant recipients
Eytan Breman, P.P. van Miert, D. Roelen, F.H. Claas, C. van Kooten;
Leiden, Netherlands
200
P2.09.07 - MHC Class I expression in hematopoietic and non-hematopoietic cells regulates NK cell licensing and viral control
Michael G. Brown, H. Wei;
Charlottesville, United States
201
P2.09.08 - KIR-HLA interactions during pregnancy impact their population frequencies
Jorg J.A. Calis, C. Kesmir;
Utrecht, Netherlands
202
P2.09.09 - HLA-B*46:01 associated with oncogenic HPV persistence
Hui-Chi Chen, Y. Chen, M. Pan, C. Lin, S. You, C. Chen;
Taipei, Taiwan
203
P2.09.10 - Haplotypes of the HLA-G gene are associated TD1
R. S. de Albuquerque, N. Lucena-Silva, C.L. Silva, E. Castelli, Eduardo Donadi, C. Mendes-Junior;
Ribeirao Preto, Brazil
204
P2.09.11 - Regulation of MHC class II expression in cancer cell lines involves the RNA binding protein EBP1
L. Pisapia, A. Cortese, P. Barba, Giovanna Del Pozzo;
Naples, Italy
205
P2.09.12 - Major Histocompatibility Complex related LEI0258 allelic segregation in chicken
Atefeh Esmailnejad, G. Nikbakht, F. Amini, N. Khazeni Oskoui;
Tehran, Iran, Islamic Republic of
206
P2.09.13 - Motifs of the naturally processed peptides presented by HLA-A*24:07
Marsia Gustiananda, D. Cox, C. McMurtrey, K.W. Jackson, D. Mojsilovic, W. Bardet, S. Cate, J. Yaciuk, S. Kaabinejadian,
W.H. Hildebrand;
Jakarta, Indonesia
207
P2.09.14 - Superior detection of antigen specific CD4+ T-cells using pMHC-II tetramers with altered C-terminal peptide
flanking residues
Christopher J. Holland, G. Dalton, D.K. Cole, A. Godkin;
Cardiff, United Kingdom
208
P2.09.15 - Genetic variants of suppressor molecule BTLA in susceptibility to prostate cancer
Lidia Karabon, A. Szczepanska, K. Tupikowski, A. Partyka, A. Tomkiewicz, A. Wojciechowski, E. Pawlak, J. Dembowski, R. Zdrojowy,
I. Frydecka;
Wroclaw, Poland
172
Posters - August 25
209
P2.09.16 - Association of HLA-G polymorphisms with gastric adenocarcinoma risk and clinical outcome
Samaneh Khorrami, R. Malekzadeh, H. Poustchi, R. Rahimi, A. Zavaran Hosseini;
Tehran, Iran, Islamic Republic of
210
P2.09.17 - Frequencies of insertion/deletion polymorphism in HLA-G gene in non-small cell lung cancer patients and healthy
controls in a Polish population sample
Piotr Kusnierczyk, A. Wisniewski, R. Jankowska, A. Kowal, I. Porebska;
Wroclaw, Poland
211
P2.09.18 - Association study among HLA, KIR, MICA, PARK2, and cytokine genes in patients with leprosy from Southern
Brazil
Priscila S. Mazini, D.S.A. Franceschi, C.C.C. Rudnick, P.G. Reis, M.T. Mira, A.M. Sell, V.M. Fava, J.E.L. Visentainer;
Maringá, Brazil
212
P2.09.19 - Association of MICA gene with the development of chronic chagasic cardiopathy
P.G. Reis, C.M. Ayo, C.F. Oliveira, Priscila S. Mazini, A.M. Sell, M.M.O. Dalalio, J.E.L. Visentainer;
Maringá, Brazil
213
P2.09.20 - MIC and NKG2D genes polymorphism in Mexican population
Miriam E. Nieves-Ramirez, E. Bravo-Flores, P.E. Alegre-Crespo, M. Tapia-Lugo, M.E. Perez-Rodriguez;
Mexico City, Mexico
214
P2.09.21 - Association between the HLA-G molecule and lymph node metastasis in papillary thyroid cancer
Larissa M. Nunes;
El Paso, United States
215
P2.09.22 - MHC class I chain related gene A polymorphism and gastroduodenal lesions in Mexican population infected
by Helicobacter pylori
Oswaldo Partida-Rodriguez, M.E. Nieves-Ramirez, L. Flores, E. Lazcano, J. Torres, M.E. Perez-Rodriguez;
Mexico City, Mexico
216
P2.09.23 - CTLA-4 and CD28 gene polymorphisms in renal cancer in the Polish population
Anna M. Partyka, K. Tupikowski, L. Karabon, A. Kolodziej, R. Zdrojowy, A. Tomkiewicz, I. Frydecka;
Wroclaw, Poland
217
P2.09.24 - Optimization of T-cell antigens for vaccine development
Johanne Pentier, G.M. Dolton, J. Ekeruche, M. Clement, D.K. Cole, J.J. Miles, D.M. Lewinsohn, D.A. Price, L. Wooldridge,
A.K. Sewell;
Cardiff, United Kingdom
218
P2.09.25 - The HLA-DRB1*01 allele confers genetic susceptibility to lepromatous leprosy in Mexicans
Rosalio Ramos-Payan, M. Escamilla-Tilch, N.M. Torres-Carrillo, M. Aguilar-Medina, M.I. Salazar, M. Fafutis-Morris, R. ArenasGuzmán, S. Estrada-Parra, I. Estrada-García, J. Granados;
Culiacan, Sinaloa, Mexico
219
P2.09.27 - HLA-DRB1*11 is associated with Papillon-Lefevre Syndrome in Mexican patients carrying a novel cathepsin C
mutation
Jose G. Romero-Quintana, M. Aguilar-Medina, L.O. Frías-Castro, J.E. Dueñas-Arias, E. Arámbula-Meraz, J.G. Romero-Navarro,
R. Ramos-Payán;
Culiacan, Sinaloa, Mexico
220
P2.09.28 - Influence of TIM-1 haplotypes on CD4 counts in HIV seroprevalent North Indians
Gaurav Sharma, G. Kaur, A. Kimura, T. Nakajima, H. Ohtani, T. Naruse, S.K. Sharma, M. Vajpayee, N.K. Mehra;
New Delhi, India
221
P2.09.29 - Association studies of functional ICOS gene polymorphisms with schizophrenia disease in the Polish population
Anna M. Tomkiewicz, L. Karabon, A.M. Partyka, D. Frydecka, A. Kiejna, A. Beszlej, I. Frydecka;
Wroclaw, Poland
222
P2.09.30 - Change of C/A at the SNP −592 of human IL-10 gene increase serum IL-10 levels in patients with cervical lesions
and cervical cancer
Kirvis J. Torres Poveda, M. Bahena Román, A. Lagunas Martínez, K. Delgado Romero, D. Cantú, A. García Carrancá, V. Madrid Marina;
Cuernavaca, Mexico
223
224
P2.09.31 - Comparison of the distribution of two promoter single nucleotide polymorphisms, -725C>G>T and -716T>G,
in non-small cell lung cancer and healthy population sample
Andrzej Wisniewski, R. Jankowska, A. Kowal, I. Porebska, M. Wagner, P. Kusnierczyk;
Wroclaw, Poland
P2.09.32 - Associations of IFN-alpha genetic variation with the functional phenotype of T subsets
Jou-Hui Yu, H. Chang, Y. Li, M. Wu, W. Chung, H. Chaung;
Pingtung, Taiwan
P3.04 GENETIC REARRANGEMENTS OF LYMPHOCYTE RECEPTORS
Session Time: Sunday, August 25, 13:20 - 15:00
225
P3.04.01 - Construction and functional activity of fibronectin scaffold containing different chains of hypervariable
complementarity determining regions of mouse antibody against human IgG4
Gregory V. Brovman, L.E. Petrovskaya, T.A. Yagudin, E.V. Svirshchevskaya;
Moscow, Russian Federation
226
P3.04.02 - Bi-polarized function of the 3’ regulatory region at the immunoglobulin heavy chain locus
F. Braikia, D. Haddad, A. Khamlichi, Caroline Conte;
Toulouse, France
173
Posters - August 25
227
P3.04.03 - Specification of the Vκ gene repertoire at the mouse Ig gene locus
Y. Xiang, S. Park, William T. Garrard;
Dallas, United States
228
P3.04.04 - Reassessing HLA-DRB3, DRB4 and DRB5 expression in different cell types
Europa A. Gonzalez-Navarro, R. Faner, E. Rigol-Monzó, X. Coll, E. Garcia, N. De Moner, L. Carretero, D. Archila, M. Juan;
Barcelona, Spain
229
P3.04.05 - Intrinsic bias and public rearrangements in the human immunoglobulin VLambda light chain repertoire
Kam Hon Hoi, G. Ippolito, G. Georgiou;
Austin, United States
230
P3.04.06 - Defects in VDJ recombination and thymocyte development induced by T cell-specific deletion of protein
phosphatase 4/PP4
E. Hsing, F. Liao, W. Hsou, Y. Lin, Y. Jhou, Ching-yu Huang;
Zhunan, Miaoli County, Taiwan
231
P3.04.07 - XLF is required for the generation of junctional diversity by TdT
Hanna IJspeert, I. Jerchel, R. Leite, N.S. Verkaik, J.J.M. van Dongen, D.C. van Gent, M. van der Burg;
Rotterdam, Netherlands
232
P3.04.08 - High throughput sequencing data reveals the shape of the immunoglobulin repertoire
Katherine J.L. Jackson, A.M. Collins;
Sydney, Australia
233
P3.04.09 - Identifying factors responsible for maintenance of immunoglobulin class switch recombination
Michael X. Le, S. Ramachandran, R.M. Nepal, A. Chopra, T. Ketela, J. Moffat, A. Martin;
Toronto, Canada
234
P3.04.10 - Detection Of Interferon Alpha Receptor 2 in Interferon Resistant HCV Patients
Suhail R. Marazi, A. Rashid, Q. Bashir;
Rawalpindi, Pakistan
235
P3.04.11 - In vivo analysis of Aicda gene regulation: critical balance between upstream enhancer and intronic repressor
for the appropriate expression
L. Huong, M. Kobayashi, M. Nakata, G. Shioi, H. Miyachi, T. Honjo, Hitoshi Nagaoka;
Gifu, Japan
236
P3.04.12 - T-cell receptor (TCR) profiling by next-generation sequencing
Tal Oron, L. Marchand, Q. Li, C. Polychronakos;
Montreal, Canada
237
P3.04.13 - AID expression in pancreas promotes an inflammatory response
Arantxa Pérez-García, P. Pérez-Durán, F. X Real, A. Ramiro;
Madrid, Spain
238
P3.04.15 - T cell receptor repertoire plasticity in peripheral CD8 T cells
Paul G. Thomas, G. Wang, J.L. McClaren, M.Y. Morris, P.C. Doherty, P. Dash;
Memphis, United States
P3.05 ANTIGEN PROCESSING AND PRESENTATION
Session Time: Sunday, August 25, 13:20 - 15:00
239
P3.05.01 - Hypoxia directly enhances dendritic cell antigen presentation
Sistiana Aiello, F. Rocchetta, N. Azzollini, P. Cassis, S. Solini, M. Mister, G. Remuzzi, M. Noris;
Ranica, Italy
240
P3.05.02 - Synthetic immunoactive fragments of Survivin: selection and application for monomer and dimer detection
Elena V. Akhidova, M.V. Kalintseva, T.D. Volkova, I.Y. Yakupov, D.O. Koroev, L.E. Zavalishina, O.M. Volpina;
Moscow, Russian Federation
241
P3.05.03 - The impact of sub-cellular localization, dose, and expression pattern of tumour antigen on cross-presentation
efficiency
Chidozie Anyaegbu, S. Fisher, R.A. Lake, B.W.S. Robinson;
Perth, Australia
242
P3.05.04 - High resolution mass spectrometry reveals unanticipated depth and diversity of HLA peptidomes
Michal Bassani-Sternberg, M. Mann;
Martinsried, Germany
243
P3.05.05 - Tumor associated MUC1 carried by microvesicles is cross-processed by Dendritic cells generating immunogenic
MUC1 glycoepitopes and is cross-presented to CD8+T cells
Federico Battisti, H. Rahimi, F. Belleudi, C. Napoletano, I. Zizzari, M. Antonilli, V. Visconti, F. Bellati, M. Nuti, A. Rughetti;
Rome, Italy
244
P3.05.06 - Differential antigen-dependency of CD4+ and CD8+ T cells
Anne C. Behrendt, H. Rabenstein, J. Ellwart, M. Horsch, J. Beckers, R. Obst;
Munich, Germany
245
P3.05.07 - Immunoproteasome induction and MHC class I molecules presentation in motor neurons
of a familial Amyotrophic Lateral Ssclerosis mouse model
G. Nardo, R. Iennaco, M. Trolese, Caterina Bendotti;
Milan, Italy
174
Posters - August 25
246
P3.05.08 - In vitro study of Thyroglobulin peptides associated to HLA-DR3 under thyroid antigen presentation conditions
Teresa Ciudad, A. Kim, J. Alonso, E.A. James, W.W. Kwok, S. Sadegh-Nasseri, D. Jaraquemada;
Cerdanyola del Valles, Spain
247
P3.05.09 - Epitopes of 21-hydroxylase targeted by autoreactive T cells in patients with autoimmune Addison’s disease are
also targeted by T cells in mice immunized with 21-hydroxylase protein
Kine Edvardsen, E. Bratland, A. Hellesen, E.S. Husebye;
Bergen, Norway
248
P3.05.10 - Sub-optimal antigen presentation of CD8+ T cell epitopes by dendritic cells infected with Trypanosoma cruzi
Jonatan Ersching, K.R. Bortoluci, M.M. Rodrigues;
São Paulo, Brazil
249
P3.05.11 - Bone marrow endothelial cells of patients with multiple myeloma: antigen presenting functions
and T cell regulation
Arianna Ferrucci, P. Leone, R. Ria, V. Racanelli, A. Vacca;
Bari, Italy
250
P3.05.12 - Inhibition of ERAP1 function promotes human NK cell immune responses against tumors: an innovative
strategy of anticancer immunotherapy
L. Cifaldi, P. Romania, D. Pende, F. Locatelli, Doriana Fruci;
Rome, Italy
251
P3.05.13 - Human mesenchymal stromal cells derived from cervical neoplasisas down-regulate the expression of HLA class I
molecules on cervical cancer cells
Rosario García-Rocha, J.J. Montesinos, M.L. Mora-García, M.C. Moreno-Lafont, M.E. Castro-Manreza, B. Weiss-Steider,
A. Monroy-García;
México, Mexico
252
P3.05.14 - Effect of MBA on therapeutic protein immunogenicity
Tal Gefen, J. Vaya, S. Khatib, D. Heller, E. Aizenstein, J. Pitcovski;
Kiryat Shmona, Israel
253
P3.05.15 - Identification of gliadin peptides restricted by the HLA Class I B8 encoded by B*0801 allele in linkage with the
celiac disease-associated DR3-DQ2 haplotype
S. Picascia, J. Sidney, A. Camarca, G. Mazzarella, A. Sada, G. Iaquinto, S. Auricchio, A. Sette, R. Troncone, Carmen Gianfrani;
Avellino, Italy
254
P3.05.16 - Identification of inducible lymphoid structures in the skin: a key site to elicit contact hypersensitivity responses
Y. Natsuaki, G. Egawa, S. Nakamizo, S. Hanakawa, T. Hashimoto, Y. Miyachi, Kenji Kabashima;
Kyoto, Japan
255
P3.05.17 - Novel antigenic MHC class I peptides are generated and presented in the absence of tapasin
Takayuki Kanaseki, K. Camfield, N. Shastri, N. Sato;
Sapporo, Japan
256
P3.05.18 - On the role of heparan sulfates in antigen cross-presentation
Delphine Knittel, A. Savatier, J. Boulain, M. Léonetti;
Gif-sur-Yvette, France
257
P3.05.19 - Porcine leukocyte antigen-derived peptides that are presented by human MHC molecules
Chong-Kil Lee, C. Park, K. Kim, S. Im;
Cheongju, Korea, Republic of
258
P3.05.20 - A new a high throughput method to assess quantitative and qualitative differences in the antibody response
Alessandra Mariani, F. Buricchi, G. Volpini, S. Budroni, A. Di Domenico, F. Castellino, G. Del Giudice, D. Medini, O. Finco;
Siena, Italy
259
P3.05.22 - Citrullination of myelin antigens increases binding to Multiple Sclerosis associated MHC class II molecules
and enhances T cell responses
Patrick C. Merky, M. Khademi, N. Abdelmagid, E.A. James, S. Haag, T. Olsson;
Stockholm, Sweden
260
P3.05.23 - Thromboxane A2 controls primary T cell - DC interactions in vivo
Federica Moalli, P. Halbherr, M. Pieczyk, S. Narumiya, J. Stein;
Bern, Switzerland
261
P3.05.24 - Independent transport of MHC class II and H2-DM to processing compartments and convergence with molecules
of distinct trafficking pathways
Jonathan Cortés Alvarez, G. Pérez-Montesinos, C. Sánchez, L.C. Bonifaz, J. Moreno;
Cuernavaca, Mexico
262
P3.05.25 - Ultrastructure of human autologous macrophage lymphocyte rosettes in Chagas disease
Ivon T.C. Novak, A.D. Orquera;
Cordoba, Argentina
263
P3.05.26 - The non-classical class II genes of the chicken, DMA and DMB, are similar to those of mammals, but a second
DMB gene (DMB1) is differentially expressed with unusual regulatory and structural features
Aimée Parker, K. Staines, C. Butter, J. Kaufman;
Cambridge, United Kingdom
264
P3.05.28 - The wild-type hemochromatosis protein HFE inhibits MHC I antigen presentation
Alexandre Reuben, M. Phénix, M.M. Santos, R. Lapointe;
Montréal, Canada
175
Posters - August 25
265
P3.05.29 - Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic
cells to T cells
V. Tardif, Sebastián A. Riquelme, S. Remy, L.J. Carreño, T. Simon, C.A. Riedel, P. Blancou, S. Bueno, I. Anegon, A.M. Kalergis;
Santiago, Chile
266
P3.05.31 - Stable antigen is most effective for eliciting CD8+ T cell responses after DNA vaccination and infection
with recombinant vaccinia virus in vivo
Christopher Schliehe, A. Bitzer, M. van den Broek, M. Groettrup;
Vienna, Austria
267
P3.05.32 - The Mer Receptor Tyrosine Kinase promotes B-cell antigen processing through the IgD B-cell Receptor
Wen-Hai Shao, Y. Zhen, F. Finkelman, P. Cohen;
Philadelphia, United States
268
P3.05.33 - Genetic Regulation of the Bovine Immune System and Implications for Health
Kathleen Thompson-Crispi, R. Ventura, F. Schenkel, F. Miglior, B. Mallard;
Guelph, Canada
269
P3.05.34 - The influence of MHCII haplotypes on T cell priming and disease development in a chronic model of rheumatoid
arthritis
Jonatan Tuncel, S. Haag, D.E. Mason, S. Thordardottir, A.C.Y. Yau, E.C. Peters, R. Holmdahl;
Stockholm, Sweden
270
P3.05.35 - Stem-cell transplantation restores CD8 T-cell immunity and corrects MHC class I deficiency
Anthony P. Williams, Y. Gao, R. Carter, A. Cazaly, S.I. Khakoo, A. Mant, A.J. Cant, S. Gadola, P.D. Arkwright, T.J. Elliott;
Southampton, United Kingdom
271
P3.05.36 - Systematic analysis of the antigen processing machinery in HPV-positive cell lines
Jan Winter, A. Steinbach, K.M. Grabowska, A.K. Grabowska, A.B. Riemer;
Heidelberg, Germany
P3.08 TH1 AND TH2 CELLS
Session Time: Sunday, August 25, 13:20 - 15:00
272
P3.08.01 - Chemokine receptor (CKR) expression on memory CD4+ Th2 cells in mice during an allergen-mediated
exacerbation of allergic asthma
Berislav Bosnjak, M.M. Epstein;
Vienna, Austria
273
P3.08.02 - The role of CD244 in regulating M. tuberculosis antigen-specific CD4+ T cell function
Xiaoxing Cheng, B. Yang, J. Jiang, X. Wang;
Beijing, China
274
P3.08.03 - Dose-dependent differential effects of thrombin in allergic bronchial asthma
Corina D’Alessandro-Gabazza, Y. Matsushima, A.L. Chelakkot Govindalayathil, Z. Roeen, T. Takagi, T. Yazuma, T. Kobayashi,
M. Toda, E.C. Gabazza;
Tsu, Japan
275
P3.08.04 - Serine protease inhibitor characteristics of human T helper 2 cells
Sanna M. Edelman, T. Äijö, I. Koho, H. Kallionpää, S. Tuomela, R. Lahesmaa;
Turku, Finland
276
P3.08.05 - New column-free procedure for the enrichment of human Th1(CD4+CXCR3+) cells from peripheral blood
Maureen Fairhurst, J. Yu, S. de Jong, T. Thomas;
Vancouver, Canada
277
P3.08.06 - Identification and characterization of the secreted form of TMEM98 that promotes Th1 cell differentiation both
in vitro and in vivo
Weiwei Fu, Y. Zhang, Y. Cheng, P. Wang, T. Li, W. Pan, D. Ma, W. Han;
Beijing, China
278
P3.08.07 - NFκB attenuates IL-5 production and upregulates T-box transcription factors in Th2-like T cells
Masaaki Hashiguchi, A. Kobayashi, Y. Kashiwakura, H. Kojima, Y. Kanno, T. Kobata;
Tochigi, Japan
279
P3.08.08 - T-lymphocytes effectors/memory cells detection by intracellular cytokines staining in children
of different age and adults
Julia G. Lagereva, J.B. Beykin;
Ekaterinburg, Russian Federation
280
P3.08.09 - Generation of mutants forms of mite allergen Der p 5 with reduce IgE binding
Sadjia Lahiani, S. Khemili, A. Bouaziz, I. Bitam, D. Gilis, M.E. Dumez, M. Galleni;
Liège, Belgium
281
P3.08.10 - The role of neuronal adhesion molecule AMIGO2 in T cell function and inflammatory diseases
Zhilin Li, J. Kuja-Panula, H. Rauvala, L. Tian;
Helsinki, Finland
282
P3.08.11 - IL-27 regulates Th1 lymphocytes and induces Th17-dependent protection against experimental Trypanosoma cruzi
infection
Tiago Medina, G.K. Silva, D. Fonseca, R. Sesti, M.C. Silva, J.S. Silva;
Ribeirao Preto, Brazil
176
Posters - August 25
283
P3.08.12 - IL-4 receptor alpha signalling on dendritic cells is required for optimal Th2 responses in house dust mite
induced allergic airway disease and schistosomiasis
Natalie E. Nieuwenhuizen, H.H. Ndlovu, F. Kirstein, R. Hurdayal, F. Brombacher;
Berlin, Germany
284
P3.08.13 - Differential mechanisms of contact hypersensitivity development to dinitrochlorobenzene (DNCB) in rats
Aleksandra Popov Aleksandrov, I. Mirkov, J. Djokic, M. Ninkov, D. Miljkovic, D. Kataranovski, M. Kataranovski;
Belgrade, Serbia
285
P3.08.14 - A novel strategy for integrating gene expression profiles derived from multiple publicly available datasets
highlights novel hub genes and pathways in mouse models of allergic asthma
MIchela Riba, J.M. Garcia-Manteiga, B. Bosnjak, M.M. Epstein, E. Stupka;
Milan, Italy
286
P3.08.15 - Expression of cytokines and transcription factors in CD4+ T cell in myasthenia gravis
V. Yilmaz, P. Oflazer, F. Aysal, Y.G. Parman, F. Deymeer, Güher Saruhan-Direskeneli;
Istanbul, Turkey
287
P3.08.16 - MiRNA expression and function in CD4 T cells from asthmatic airways
Laura J. Simpson, G. Seumois, P. Vijayanand, P. Woodruff, M. Ansel;
San Francisco, United States
288
P3.08.17 - Differences in the polarization of the inflammatory response of patients with chronic obstructive pulmonary
disease (COPD) secondary to smoking and to biomass smoke exposure
Helena Solleiro-Villavicencio, M.I. Vargas-Rojas, A. Ramírez- Venegas, R.H. Sansores-Martínez, M. Velázquez-Uncal, O. Pérez-Bautista,
R. Quintana, R. Falfán-Valencia, I. Pupko-Sissa;
Mexico City, Mexico
289
P3.08.18 - Transgenic Expression of Survivin Compensates the OX40-Deficiency in Driving Th2 Development and Allergic
Inflammation
Jim Song, D. Lei, R. Haque;
Hershey, United States
290
P3.08.19 - Resistin, Tumor Necrosis Factor-α and Insulin Resistance in Normal Pregnancy
Abdolreza Sotoodeh Jahromi, F. Mehdizadeh;
Jahrom, Iran, Islamic Republic of
291
P3.08.20 - Identifying the T helper cell population involved in class-switching to IgE
Sharrada Subramaniam, J. He, L. Jones, M. Curotto de Lafaille;
Singapore, Singapore
292
P3.08.21 - Retrogenic expression of human TCR in HLA-DR4 transgenic NOG mice
Takeshi Takahashi, I. Katano, R. Ito, M. Ito;
Kawasaki, Japan
293
P3.08.22 - The effect of toll-like receptor 4 on the development of acquired immunity against Salmonella infection
Panagiotis Tourlomousis, P. Mastroeni, K.A. Fitzgerald, D.J. Maskell, C.E. Bryant;
Cambridge, United Kingdom
294
P3.08.23 - Formation of the utero-(pre) placental blood flow in pregnant women with threatened abortion
in early pregnancy due to impaired immune-hormonal homeostasis
Iryna I. Voronova, T.N. Demina;
Donetsk, Ukraine
295
P3.08.24 - Myofibroblast Apoptosis, Removal from the Lungs and Attenuation of Fibrosis by FasL+ Immune Cells
Shulamit B. Wallach-Dayan, L. Elkayam, R. Golan-Gerstl, R. Breuer;
Jerusalem, Israel
296
P3.08.25 - Impact of immunosuppressive drugs on killing capacity and cytokine production of BKV-specific T cells
Benjamin J.D. Weist;
Berlin, Germany
297
P3.08.26 - Bromodomain-Containing-Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation
in Human CD4+ T Cells
Joe, poh sheng Yeong, W. Zhang, P. Celine, C. Sum, N. Thiessen, S. Jones, S. Pettersson, S. Knapp, H. Yang, K. Chin;
Singapore, Singapore - Moved to August 26 in P2.12: Signaling in immune cells in pag. 205
298
P3.08.27 - Effect of extremely low frequency electromagnetic field (ELF-EMF) on some cytokines production of rats
Alireza Zamani, I. Salehi, K. Ghazikhanlou Sani;
Hamadan, Iran, Islamic Republic of
P3.13 REGULATORY T CELLS: BASIC ASPECTS
Session Time: Sunday, August 25, 13:20 - 15:00
299
P3.13.01 - Increased CD8+ regulatory T cells in breast cancer
F. Riazi-Rad, Z. Saraf, R. Omranipour, M. Alimohammadian, Soheila Ajdary;
Tehran, Iran, Islamic Republic of
300
P3.13.02 - Regulatory T cells during tumor development in the APCmin/+ mouse model of colon cancer
Paulina Akeus, V. Langenes, A. von Mentzer, S. Raghavan, M. Quiding-Järbrink;
Gothenburg, Sweden
177
Posters - August 25
301
P3.13.03 - Asymptomatic Leishmania major-infected individuals exhibit lower frequency of regulatory T cells compared to
the healed individuals
Mohammad Hossein Alimohammadian, F. Bahrami, H. Darabi, F. Riazi-Rad, V. Khaze, S. Ajdary;
Tehran, Iran, Islamic Republic of
302
P3.13.04 - Analysis of the Treg cell proteome by differential quantitative mass spectrometry
Melanie Barra, D. Richards, J. Hansson, M. Delacher, J. Krijgsveld, M. Feuerer;
Heidelberg, Germany
303
P3.13.05 - Association between SNP rs 2234711 and tuberculosis
Behnoush Beiranvand, S. abediankenari, M. Rezaei, E. beiranvand;
Ahvaz, Iran, Islamic Republic of
304
P3.13.06 - Prolactin Effect in Cd4+Cd25hicd127low/- Regulatory T Cell Function in Human
Francisco Blanco-Favela, V. Legorreta-Haquet, K. Chávez-Rueda, E. Montoya-Diaz, L. Chavez-Sanchez, L. Arriaga-Pizano, E. ZentenoGalindo;
México City, Mexico
305
P3.13.07 - Regulatory T-cells of mouse display distinctive surface glycosylation patterns and enhanced responsiveness to
lectin-induced proliferation
Joana Cabral, S. Hanley, J. Gerlach, L. Lokesh, T. Ritter, R. Ceredig, M.D. Griffin;
Galway, Ireland
306
P3.13.08 - Immunological consequences of HIV co-infection with M. Leprae
Karina I. Carvalho, F.R. Bruno, J. Tomimori, L. Nogueira, E. Moreira, E. Cunha-Neto, M.B. Xavier, J. Kalil, D. Nixon, E.G. Kallas;
São Paulo, Brazil
307
P3.13.09 - PDCD5 negatively regulates autoimmunity by upregulating FOXP3+ regulatory T cells
and suppressing Th17 and Th1 responses
J. Xiao, C. Liu, G. Li, J. Hu, Y. Zhang, D. Ma, Yingyu Chen;
Beijing, China
308
P3.13.10 - The endocannabinoid 2-Arachidonoylglycerol potentiates Foxp3 expression and Regulatory T cell functions
through its metabolism
Valerio Chiurchiu, M. Lanuti, M. De Bardi, N. Battista, E. Bisicchia, G. Borsellino, M. Maccarrone, L. Battistini;
Rome, Italy
309
P3.13.11 - Altered expression of miR-146a and miR-155 in Th2 and IgG expressing B cells in the autoimmune disease
pemphigus foliaceus
Gabriel A. Cipolla, M. Petzl-Erler;
Curitiba, Brazil
310
P3.13.12 - DX5+ CD4+ T cells modulate CD4+ T-cell response via inhibition of IL-12 production by DCs
Hanane el Bannoudi, W.G. Han, J.N. Stoop, P. Louis-Plence, T.W.J. Huizinga, R.E.M. Toes;
Leiden, Netherlands
311
P3.13.13 - T regulatory cells in cancer
Eyad Elkord;
Al Ain, United Arab Emirates
312
P3.13.14 - Regulatory T cells in acute lymphoblastic leukemia
Mariana H. Garcia Hernandez, S. Godina Gonzalez, M.N. Medina Rosales;
Zacatecas, Mexico
313
P3.13.15 - T Lymphocyte-mediated suppression of murine granulopoiesis by oral allergen pretreatment
of sensitized/challenged mice
Maria Gaspar-Elsas, T. Queto, B. de Luca, B. Vieira, C.L.C.A. Silva, R.A. Luz, R. Ferreira, P.P. Xavier-Elsas, D. Masid-de-Brito;
Rio de Janeiro, Brazil
314
P3.13.16 - Augmented levels of CD4+CD25high Treg cells in peripheral blood of patients with acute
and chronic brucellosis
Hadi Ghazanfari, N. Hassannejad, A. Bahador, A. Bahador, J. Hajati;
Isfahan, Iran, Islamic Republic of
315
P3.13.17 - Association of circulating regulatory T cell number with the incidence and prognosis
of diffuse large B cell lymphoma
Magdalena Głowala-Kosi ska, A. Chwieduk, J. Nieckula, M. Sadu -Wojciechowska, S. Grosicki, A. Rusin, E. Nowara, S. Giebel;
Gliwice, Poland
316
P3.13.18 - Maintenance of memory regulatory T cells in peripheral tissues
Iris K. Gratz, M.D. Rosenblum, H. Truong, M.M. Maurano, A.K. Abbas;
San Francisco, United States
317
P3.13.19 - Beta2 adrenergic receptor signaling in CD4+ Foxp3+ regulatory T cells enhances their suppressive function in vitro
Marcia G. Guereschi, L.P. Araujo, J.T. Maricato, M.C. Takenaka, V.M. Nascimento, B.C. Vivanco, V.O. Reis, A.C. Keller, A.S. Basso;
São Paulo, Brazil
318
P3.13.20 - Role of cutatneous regulatory T cells in regulation of immune homeostasis and contact hypersensitivity reaction in
the skin
Sho Hanakawa, A. Kitoh, Y. Miyachi, K. Kabashima;
Kyoto, Japan
319
P3.13.21 - Genome-wide DNA methylation profiling identifies hypomethylated genes with the Forkhead-binding motif in
human regulatory T cells
Y. Zhang, J. Maksimovic, G. Naselli, J. Qian, M.E. Blewitt, A. Oshlack, Leonard C. Harrison;
Melbourne, Australia
178
Posters - August 25
320
P3.13.22 - Identification of PLAU as a critical gene for the suppressive function of memory-like CD4+ regulatory T cells
Feng He, H. Chen, M. Probst-Kepper, R. Geffers, S. Eifes, A. del Sol, K. Schughart, A. Zeng, R. Balling;
Esch-Belval, Luxembourg
321
P3.13.23 - CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied
by downregulation of Bim
Yuji Kashiwakura, D. Sakurai, Y. Kanno, M. Hashiguchi, A. Kobayashi, A. Kurosu, S. Tokudome, T. Kobata, H. Kojima;
Mibu, Shimotsuga, Tochigi, Japan
322
P3.13.24 - Diurnal changes in trafficking receptor expression on thymus-deriving natural regulatory T cells
Ewelina Kiernozek, A. Kowalik, K. Niedzielska, M. Markowska, N. Drela;
Warsaw, Poland
323
P3.13.25 - Dexamethasone dose-dependent effect on nTreg generation in vitro in thymocytes co-cultures with JAWSII cells
Anna Kowalik, K. Gugala, E. Kiernozek, E. Kozlowska, N. Drela;
Warsaw, Poland
324
P3.13.26 - Donor-specific regulatory t cells generated on donor b cells are superior to CD4+CD25high cells in controlling
alloimmune responses in humanized mice
Young-Seon Lee, F. Noyan, M. Hardtke-Wolenski, A. Knoefel, R. Taubert, U. Baron, M.P. Manns, E. Jaeckel;
Hannover, Germany
325
P3.13.27 - TIP60 Positively Regulates ThPOK-Mediated Repression of Eomesodermin in Human CD4+ T Cells
Bin Li, Y. Li;
Shanghai, China
326
P3.13.28 - The effects of 5-azacytidine on the enhancement of CD4+CD25highFOXP3+ T cells from the cultures of human
CD4+CD25- T cells
Chun-Hao Lu, C. Wu, M. Kuo;
Taoyuan, Taiwan
327
P3.13.29 - Ctirical roles of the transcriptional regulator IκB-ζ in regulatory T cells
Takashi Maruyama, T. Muta;
Sendai, Japan
328
P3.13.30 - Differential sialylation dictates the fate of regulatory T cells
Santiago P. Mendez Huergo, T. D´Alotto Moreno, M. Toscano, J.P. Cerliani, D.O. Croci, K. Mariño, G.A. Rabinovich;
Buenos Aires, Argentina
329
P3.13.31 - Thymic precursors of T regulatory cells are resistant to caspase/granzyme B mediated degradation of Linker for
activation of T cells
M. Klossowicz, B. Scirka, K. Marek-Bukowiec, P. Kisielow, Arkadiusz Miazek;
Wroclaw, Poland
330
P3.13.32 - Effect of gestational age and mode of delivery on CD4+ T cells and regulatory T cells (Treg) in neonatal cord
blood
Dhriti Mukhopadhyay, L. Weaver, R. Tobin, D. Jupiter, M.K. Newell-Rogers, L. Perger;
Temple, United States
331
P3.13.33 - Adenosine production through CD39 and CD73 mediates development of sepsis-induced immunossupression
via A2a receptor
Daniele C.B. Nascimento, P.H. Melo, R.G. Ferreira, R.S. Peres, D.S. Zamboni, F.Q. Cunha, J.F. Alves-Filho;
Ribeirão Preto, Brazil
332
P3.13.34 - CD4+ regulatory T lymphocytes in preeclamptic women and in their newborns: preliminary results
David Felipe Navarro Barquín, L. Daza Benitez, S. López Briones, A. Macías Rocha, P. González;
León de los Aldamas, Mexico
333
P3.13.35 - The influence of regulatory T cells on the response to the measles and DTP vaccines in Gambian infants
Jorjoh Ndure, F. Noho-Konteh, J. Adetifa, S. Rowland-Jones, E. Clarke, J. Sutherland, H. Whittle, M. Plebanski, M. Ota, K. Flanagan;
Banjul, Gambia
334
P3.13.36 - Homeostatic competition of regulatory T cells in the peripheral compartment of syngeneic and semi-allogeneic
hosts
Jeane S. Nogueira, C.F.C.G. Nunes, F.B. Canto, P.H.O. Vianna, M.M.C. Ferreira, A. Nóbrega, M. Bellio, R. Fucs;
Rio de Janeiro, Brazil
335
P3.13.37 - Regulatory T cells are preferentially preserved over non-Tregs within neonatal-derived T cells present in adult
mice
Caroline F. Nunes, J.S. Nogueira, F.B. Canto, P. Vianna, M. Martins, M. Bellio, A. Nóbrega, J. Mengel, R. Fucs;
Rio de Janeiro, Brazil
336
P3.13.38 - Identification of an endogenous subpopulation of regulatory CD8+ T cells specific for a tissue-restricted tumor
associated antigen in tumor-bearing TRAMP mice
Sara Martina Parigi, N. Rigamonti, E. Degl’Innocenti, E. Jachetti, M. Grioni, M. Bellone;
Milan, Italy
337
P3.13.39 - CD39 is highly involved in mediating the suppressive activity of tumor-infiltrating CD8+ T regulatory lymphocytes
Alessia Parodi, F. Battaglia, F. Kalli, F. Ferrera, G. Conteduca, G. Borgonovo, P. Traverso, G. Carmignani, D. Fenoglio, G. Filaci;
Genova, Italy
338
P3.13.40 - The hunt for a natural regulatory T cell ligand
Matt Phillips, J. Scott-Browne, J. Kappler, P. Marrack;
Denver, United States
179
Posters - August 25
339
P3.13.41 - CD8+ regulatory T cells recognize donor MHC class II-derived immunomodulatory epitopes
in an allotransplantation model
E. Picarda, S. Bézie, A. Delhumeau, K. Renaudin, E. Mérieau, I. Anegon, Carole Guillonneau;
Nantes, France
340
P3.13.42 - Interferon-alpha plays complex roles in human regulatory T cell deprogramming into Th1-like cells
Silvia Piconese, Y. Pacella, E. Timperi, D. Accapezzato, G. Labbadia, V. Barnaba;
Rome, Italy
341
P3.13.43 - Inducible IL-10 secreting CD49b+Treg cells as cell based-therapy for rheumatoid arthritis
Julie Quentin, R. Vicente, D. Martire, A. Mausset-Bonnefont, C. Jorgensen, P. Louis-Plence;
Montpellier, France
342
P3.13.44 - Systems analysis of innate activation reveals IL-1 family members as key modulators of T cells susceptibility to
regulation and novel targets for therapeutic intervention
Giorgio Raimondi, Y.T. Nicholson, C. Ziraldo, R. Starzl, S. Schneeberger, A.W. Thomson, G. Brandacher, Y. Vodovotz;
Baltimore, United States
343
P3.13.45 - CD39 expression on Treg cells is genetically determined and can be further modulated upon activation
Anne Rissiek, A. Cuapio, I. Baumann, A. Dodge-Khatami, P.C. Arck, F. Koch-Nolte, F. Haag, E. Tolosa;
Hamburg, Germany
344
P3.13.46 - ART2 blockade during cell preparation preserves the vitality and function of Tregs and iNKT cells
Björn Rissiek, W. Danquah, F. Haag, F. Koch-Nolte;
Hamburg, Germany
345
P3.13.47 - miR-21 transfection can differentiate human naïve T cells to regulatory phenotype
Eisa Salehi, H. Namdari, M. Ghayedi, P. Rahimzadeh, S. Mortezagholi, Z. Gheflati, J. Hajati, B. Dolatshah Earaghi;
Tehran, Iran, Islamic Republic of
346
P3.13.48 - Nr4a nuclear orphan receptors are essential for thymic regulatory T cell development and immune homeostasis
Takashi Sekiya, A. Yoshimura;
Tokyo, Japan
347
P3.13.49 - CD8+CD122+CD49d- regulatory T cells maintain immune homeostasis by Fas/FasL pathway-mediated killing
of activated T cells
Haruhiko Suzuki, K. Akane, K. Isobe;
Nagoya, Japan
348
P3.13.50 - Regulatory T cells in peripheral blood and tissue of active generalized vitiligo
Manoj K. Tembhre, V.K. Sharma, A. Sharma, P. Chattopadhyay, S. Gupta;
New Delhi, India
349
P3.13.51 - Characterization of the role of hydroxyprostaglandin dehydrogenase in regulatory T cells
Yasser Thabet, E. Schönfeld, M. Mai, T. Sadlon, K. Subbaramaiah, A.J. Dannenberg, T. Sparwasser, S.C. Barry, J.L. Schultze, M. Beyer;
Bonn, Germany
350
P3.13.52 - Regulatory T cell plasticity in HCV-related liver inflammation and tumor
Eleonora Timperi, Y. Pacella, M. Rossi, G. Grazi, S. Brozzetti, V. Barnaba, S. Piconese;
Roma, Italy
351
P3.13.53 - Application of novel Brilliant Violet™ fluorophores for multicolor flow cytometric analysis: phenotyping
of regulatory T cells and conventional T cell subsets by surface and intracellular staining
Carsten Wiethe, E. Tolosa, D. Nguyen, J. Ransom, C. Monell, X. Xiang, N. Jiang, G. Lay;
San Diego, United States
352
P3.13.54 - PPAR-alpha deficiency modulates Treg cell functions and contributes to inhibit tumor growth in mice
Akadiri Yessoufou, A. Hichami, F. Salvadori, K. Moutairou, W. Wahli, N.A. Khan;
Cotonou, Benin
P4.01 IMMUNITY TO VIRUS INFECTION
Session Time: Sunday, August 25, 13:20 - 15:00
353
P4.01.001 - T-and B-cell responses to human rhinovirus infection
Alar Aab, W. van de Veen, S. Söllner, O. Wirz, B. Stanic, M. Akdis, C. Akdis;
Davos Platz, Switzerland
354
P4.01.002 - Tax-1-mediated HTLV-1 replication and NF-kB activation is inhibited by the MHC-II transactivator CIITA
R. Abdallah, G. Forlani, Roberto S. Accolla, G. Tosi;
Varese, Italy
355
P4.01.003 - Detection of the autoimmunity in primary Epstein-Barr virus infection by indirect immunofluorescence
A. Sener, Ilhan Afsar, H. Er, B. Karaayak Uzun, S. Kaya;
Izmir, Turkey
356
P4.01.004 - Human cytomegalovirus UL141 targets the TRAIL death receptors to inhibit host NK cell responses
Rebecca J. Aicheler, P. Tomasec, W. Smith, E.C.Y. Wang, R.J. Stanton, C.A. Benedict, G.W. Wilkinson;
Cardiff, United Kingdom
357
P4.01.005 - ERAP deficiency leads to absence of anti-influenza immune response to known immunodominant HLA-B27
peptide
Ali Akram, R. Inman;
Toronto, Canada
180
Posters - August 25
358
P4.01.006 - NF-kappaB1 is required for virus-specific CD8+ T cell responses, and prevents excessive inflammation and
lethality during chronic infection
Cody C. Allison, R. Gugasyan, S.P. Preston, J.P. Cooney, J.G. Toe, G. Ebert, M. Pellegrini;
Melbourne, Australia
359
P4.01.007 - CD56+CD3+ T cells in relation to CMV infection in normal subjects and kidney transplant patients
Mazen M. Almehmadi, S. Christams, B. Flangan, S. Heyworth, A. Hammad;
Liverpool, United Kingdom
360
P4.01.008 - Involvement of NK cells in the acute lung injury of H1N1 influenza infection
X. Zhang, W. Deng, L. Bao, M. Wen, B. Cao, C. Wang, Yunqing An;
Beijing, China
361
P4.01.009 - Human cytomegalovirus viral IL-10 polarizes monocytes towards a deactivated M2c phenotype to repress host
immune responses
Selmir Avdic, J.Z. Cao, B.P. MsSharry, L.E. Clancy, R. Brown, M. Steain, D.J. Gottlieb, A. Abendroth, B. Slobedman;
Sydney, Australia
362
P4.01.010 - Quantitation of mRNA cytokine levels in ferrets following influenza infection
L.A. Carolan, J. Butler, S. Rockman, A.C. Hurt, A. Kelso, Ian G. Barr, K.L. Laurie;
North Melbourne, Australia
363
P4.01.011 - Reproducibility of Pentamer and Streptamer staining of CMV-specific CD8+ T-cells: defining the optimal
multimer concentration and incubation conditions
Lorea Beloki, N. Ramirez, M. Ciaurriz, C. Mansilla, A. Zabalza, E. Bandres, M. Rodriguez-Calvillo, E. Olavarria;
Pamplona, Spain
364
P4.01.012 - KIR2DL2 overexpression influences NK cell response to CpG
Daria Bortolotti, A. Rotola, D. Di Luca, R. Rizzo;
Ferrara, Italy
365
P4.01.013 - HLA-G influences nasal polyp relapse in HPV positive patients
R. Rizzo, Daria Bortolotti, N. Malagutti, V. Gentili, A. Rotola, T. Pezzolo, C. Fabbri, C. Aimoni, S. Pelucchi, D. Di Luca;
Ferrara, Italy
366
P4.01.014 - Beta-amyloidogenic peptides protect against Herpes Simplex Virus-1 (HSV-1) infections
Karine Bourgade-Navarro, G. Giroux, C. Bocti, A. Le Page, G. Dupuis, E.H. Frost, T. Fülöp;
Sherbrooke, Canada
367
P4.01.015 - HSV-1 infection causes reduced surface expression of MHCII and co-stimulatory molecules on infected DC
and suppressed T cell activation in vitro
Ramachandramouli Budida, M.V. Stankov, K. Doehner, A. Buch, B. Sodeik, G.M.N. Behrens;
Hannover, Germany
368
P4.01.016 - Lethal immune mediated-disease after LCMV infection in STAT1 KO mice requires interferon regulatory factor
7 and is driven by type I interferon
Iain L. Campbell, W. Li, M.J. Hofer;
Sydney, Australia
369
P4.01.017 - Influenza vaccination leads to dramatic redistribution of lymph node resident dendritic cells into inter-follicular
regions
M.C. Woodruff, S. Turley, Michael C. Carroll;
Boston, United States
370
P4.01.019 - Rapid T cell activation following Epstein-Barr virus transformed lymphoblastoid cell line co-culture with
peripheral blood mononuclear cells from cytomegalovirus positive but Epstein-Barr virus naïve children
Claudia Carvalho-Queiroz, S. Saghafian-Hedengren, N. Nagy, C. Nilsson, E. Sverremark-Ekström;
Stockholm, Sweden
371
P4.01.020 - Seroprevalence against pandemic influenza virus A/H1N1/2009 in pregnant women
Arturo Cérbulo-Vázquez, G. Cruz-Cureño, I. Garate-Bosco, C. López Macías, A. Isibasi, L. Arriaga-Pizano, J. Mancilla;
Mexico City, Mexico
372
P4.01.021 - Role of CD48 in regulation of T-cell mediated immunity in HTLV-1 infection
Chioma E. Chibueze, Y. White, M. Yoshimitsu, K. Uozumi, N. Arima;
Kagoshima, Japan
373
P4.01.022 - Identification of Antiviral-related Genes Up-regulated in Response to Bombyx mori Nucleopolyhedrovirus
T. Goo, S. Kim, Kwangho Choi, S. Kim, S. Park, S. Kang, E. Yun;
Suwon, Korea, Republic of
374
P4.01.024 - Cross-reactive antibodies to swine influenza viruses in adults after vaccination with trivalent inactivated
influenza vaccine in Korea
Jang-Hoon Choi, N. Lee, K. Shin, C. Kang;
Osong-eup, Korea, Republic of
375
P4.01.025 - Pentamers and streptamers for the monitoring of CMV-specific CD8+ T-cell immune reconstitution after
allogeneic stem cell transplantation: a comparative analysis
Miriam Ciaurriz, N. Ramirez, L. Beloki, C. Mansilla, A. Zabalza, E. Bandres, M. Rodriguez, E. Olavarria;
Pamplona, Spain
376
P4.01.026 - Targeted PGE2 inhibition enhances anti-influenza immunity through induction of type I IFN in Macrophages
Maziar Divangahi, F. Coulombe, J. Jaworska, M. Verway, F. Tzalepis, G. Kobinger, P. Joubert, J.H. Fritz, Z. Xing, W.S. Powell;
Montreal, Canada
181
Posters - August 25
377
P4.01.027 - Serological survey of BTV in Morocco
Kamar Drif, O. Fassi Fihri, C. Loutfi, G. Sebbar, M. Moulay Ennaji, M. Elharrak;
Rabat, Morocco
378
P4.01.028 - Prevalence of human papillomavirus subtypes in breast cancer in Moroccan woman
Amal Elamrani, M. Ennaji, M. Benhassou, M. Attaleb, M. Mzibri, M. Corbex, M. Tomassino, T. Gheit, M. Khyatti;
Casablanca, Morocco
379
P4.01.029 - Lung CD8+ T cell impairment during acute viral respiratory infection is associated with a unique gene expression
profile
John J. Erickson, P. Lu, P. Gilchuk, S. Joyce, Y. Shyr, J.V. Williams;
Nashville, United States
380
P4.01.030 - The complement system has a critical role in the inflammatory reaction that follows influenza virus infection
Santiago F. Gonzalez, C. Herndon, J. Ortin, M. Carroll;
Bellinzona, Switzerland
381
P4.01.031 - Human cytomegalovirus directly supress CD4 T-lymfocyte activation and proliferation
Olesja Fornara, J. Odeberg, Z. Khan, G. Stragliotto, I. Peredo, L. Butler, C. Söderberg Nauclér;
Stockholm, Sweden
382
P4.01.032 - Narrowing of influenza A virus specific T-cell receptor alpha and beta repertoire with increasing age
A. Gil, M.B. Yassai, Y.N. Naumov, Liisa K. Selin;
Worcester, United States
383
P4.01.033 - Study of humoral immune response in patients with tick-borne encephalitis against the background of virus
circulation
Anatoliy P. Godovalov, L.P. Bykova;
Perm, Russian Federation
384
P4.01.034 - Some liquorogic features of meningeal form of tick-borne encephalitis
Anatoliy P. Godovalov, L.P. Bykova;
Perm, Russian Federation
385
P4.01.035 - EBV infection leads to activation of chronic lymphocytic leukemia (CLL) cells and worsen clinical prognosis
in CLL patients
J. Rolinski, Ewelina Grywalska, A. Bojarska-Junak, P. Grabarczyk;
Lublin, Poland
386
P4.01.036 - Activation of type III interferon response by human paramyxovirus infection
Maria Guerrero-Plata, R. Banos-Lara, L. Harvey, A. Mendoza;
Baton Rouge, United States
387
P4.01.037 - Influenza virus NS1 protein counteracts ZAPS function to evade RIG-I-mediated antiviral defence
Sumio Hayakawa, T. Kameyama, T. Yamada, A. Takaoka;
Sapporo, Japan
388
P4.01.038 - Virus-associated activation of innate immunity induces rapid disruption of Peyer’s patches in mice
Simon Heidegger, D. Anz, N. Stephan, B. Bohn, T. Herbst, K. Eisenächer, C. Hotz, S. Endres, C. Bourquin;
Munich, Germany
389
P4.01.039 - Aged-related changes in the immune response to influenza infection
Esteban A. Hernandez-Vargas, T. Ebensen, S. Binder, C. Guzman, M. Meyer-Hermann;
Braunschweig, Germany
390
P4.01.040 - Myeloid derived supressor cells restrain Natural Killer cell activity in CVB3 myocarditis
Lisa M. Holz, M. Sauter, N. Ettischer, R. Kandolf, K. Klingel;
Tuebingen, Germany
391
P4.01.041 - Influenza-specific B cell response in the human challenge model for influenza A virus
Arthur K.Y. Huang, C. Li, C. Chui, T. Wilkinson, R. Lambkin-Williams, A. Gilbert, J. Oxford, A.J. McMichael, X. Xu;
Taoyuan, Taiwan
392
P4.01.042 - Inhibition of monocyte differentiation into dendritic cells by HTLV-I-infected breast milk macrophages
Shinichiro Inagaki, M. Takahashi, Y. Fukunaga, H. Takahashi;
Tokyo, Japan
393
P4.01.043 - Dengue and other flavi virus specific T cell specific responses in healthy individuals in Sri Lanka
Kamal C. Jeewandara, G.N. Malavige, T.N. Adikari, M. Salimi, M.H.J.D. Ariyaratne, M. Peellawate, V. Jayasuriya, G.S. Ogg;
Nugegoda, Sri Lanka
394
P4.01.045 - Release of interleukin-1alpha from herpes simplex virus 1 infected keratinocytes provides a functional danger
signal
K.A. Milora, Liselotte E. Jensen;
Philadelphia, United States
395
P4.01.046 - Elevated plasma soluble Sema4D/CD100 level in patients with hemorrhagic fever with renal syndrome: positive
correlation with disease severity
Boquan Jin, B. Liu, Y. Ma, J. Yi, Z. Xu, Y. Zhang, C. Zhang, R. Zhuang, J. Wang, Y. Zhang;
Xi’an, China
396
P4.01.047 - Evaluation of the immune response of live attenuated mumps vaccines (RS-12 strain) produced with different
stabilizers in guinea pigs
Razieh Kamali Jamil, Z. Sadigh, M. Taqavian, M. Shahkarami, F. Esna-Ashari;
Karaj, Iran, Islamic Republic of
182
Posters - August 25
397
P4.01.048 - A NK complex-linked locus restricts the spread of Herpes simplex virus type 1 (HSV-1) in the central nervous
system (CNS) of C57BL/6 mice
Lorne F. Kastrukoff, A.S. Lau, F. Takei, A.A. Scalzo, F.R. Carbone;
Vancouver, Canada
398
P4.01.049 - The importance of cross-strain protective human TCR signatures for universal immunity against influenza
S. Valkenburg, S. Quinones Parra, L. Loh, S. Gras, L. Kedzierski, J. Rossjohn, P.C. Doherty, S. Turner, P.G. Thomas, Katherine Kedzierska;
Parkville, Australia
399
P4.01.050 - T cell mediated mortality in neonatal mice upon LCMV infection
Laurie L. Kenney, E.P. Carter, L.K. Selin;
Worcester, United States
400
P4.01.051 - Association between IL-28B(rs12979860) polymorphisms of interferon-λ (IFN- λ) family with Hepatitis C virus
infection outcome
Rezvan Khajavi, A. Rafiei;
Sari, Iran, Islamic Republic of
401
P4.01.052 - Regulatory T cells in persistently virus infected hosts influenced immune responses against superinfection
with unrelated viruses
J. Duppach, S. Francois, T. Sparwasser, U. Dittmer, Anke R.M. Kraft;
Hannover, Germany
402
P4.01.053 - Granzyme B mediated T-cell immunity against small DNA viruses
Arun Kumar, A. Kantele, L. Hedman, K. Hedman, R. Franssila;
Helsinki, Finland
403
P4.01.054 - TLRs expression dynamics in patients with herpes-associated erythema multiforme due to immunotherapy
E.A. Sorokina, N.K. Akhmatova, S. Skhodova, Olga V. Lebedinskaya;
Perm, Russian Federation
404
P4.01.055 - Interferon-γ regulates contraction of the influenza-specific CD8 T cell response and limits the size of the memory
population
N. Prabhu, Debbie C.P. Lee, A.W. Ho, K.H.S. Wong, P.E. Hutchinson, Y. Chua, S. Baalasubramanian, D.M. Kemeny;
Singapore, Singapore
405
P4.01.056 - Regulation of inducible expression of syncytin-1 following influenza A/WSN/33 virus infection
Fang Li, C. Nellåker, A. Johansson, B. Owe-Larsson, S. Sabunciyan, H. Karlsson;
Stockholm, Sweden
406
P4.01.057 - Profile of NAb responses in HIV-1-infected individuals in China and epitope analysis of viral envelope from
broad neutralizers
C. Ren, S. Liu, Y. Li, H. Yu, J. Wang, Z. Chen, F. Sun, W. Liu, S. Liang, P. Zhong, M. Zhuang, Hong Ling;
Harbin, China
407
P4.01.058 - Delivery of human EV71 receptor by adeno-associated virus increase EV71 infection in adult mice
Shih-Jen Liu, H. Shiao, A. Chou, S. Lin, I. Chen, P. Chong, M. Tao;
Miaoli County, Taiwan
408
P4.01.059 - Double-stranded RNA (dsRNA)-induced IP-10/CXCL-10 production is augmented by Fas activation
Caitriona Lyons, R. Moran, A. Houston, E. Brint;
Cork, Ireland
409
P4.01.060 - Contribution of Hantaan virus-specific CD4+ T cells to anti-viral T-cell response in humans
Ying Ma, B. Yuan, Y. Zhang, Y. Zhang, B. Liu, C. Zhang, R. Zhuang, B. Jin;
Xi’an, China
410
P4.01.061 - CD200R1 is required for sustained HSV-1 infection and for HSV-induced and TLR2-dependent response
Christopher R. MacKay, E. Kurt-Jones;
Worcester, United States
411
P4.01.062 - α-defensin-induced MxA expression in healthy human periodontal tissue
Rangsini Mahanonda, N. Sa-Ard-Iam, P. Rerkyen, A. Thitithanyanont, K. Subbalekha, S. Pichyangkul;
Bangkok, Thailand
412
P4.01.063 - Immflammation in Influenza A H1N1 pandemic virus
Pamela Martinez-Orellana, R. Almansa, B. Bidana, L. Cordoba, J. Martínez, J. Bermejo-Martin, M. Montoya;
Barcelona, Spain
413
P4.01.064 - Strategies eliciting cross-reactive CD8+ T cell immunity by increasing cross presentation of nonreplicating viral
immunogens
Carmela Martire, B. Garulli, G. Di Mario, M.R. Castrucci, V. Barnaba, D. Accapezzato;
Rome, Italy
414
P4.01.065 - mTOR-dependent regulation of mucosal CD8 T cell immunity
R.T. Sowell, M. Rogozinska, C.E. Nelson, V. Vezys, Amanda L. Marzo;
Chicago, United States
415
P4.01.066 - mTOR regulates protection against a lethal H5N1 influenza infection by modulating the antibody response
Maureen A. McGargill, R. Keating, T. Hertz, M. Wehenkel, T.L. Harris, B.A. Edwards, J.L. McClaren, S.A. Brown, P.C. Doherty, P. Thomas;
Memphis, United States
416
P4.01.067 - Influence of the factors OCT3/4, SOX2, KLF4 or c-Myc on cell transformation promoted by the oncoprotein tax
from HTLV-I
Gustavo E.A.B. Melo, K.T. Jeang, L. Zane, E.R. Vieira;
Diamantina, Brazil
183
Posters - August 25
417
P4.01.069 - Immune deficiency in newborns and infants with cytomegalovirus infections
Nushaba O. Mollayeva;
Baku, Azerbaijan
418
P4.01.070 - APOBEC3 deaminases induce hypermutation in human papillomavirus 16 viral genomic DNA upon
interferon-β stimulation
Masamichi Muramatsu, Z. Wang, K. Wakae, K. Kitamura, M. Nakamura, S. Kyo, I. Kukimoto;
Kanazawa, Japan
419
P4.01.071 - Rapid method to screen for CMV, EBV, and AdV specific T cells in multiple samples
Michaela Niemöller, K. Lange, S. Weber-Lohmann, S. Höher-Peters, M. Assenmacher, A. Richter;
Bergisch Gladbach, Germany
420
P4.01.072 - Polyfunctional T cells are generated concurrent with the establishment of immunodominance hierarchy during
the evolution of the T cell responses to Epstein-Barr virus
Jia Ning, K.H. Chan, A.K.S. Chiang;
Hong Kong, China
421
P4.01.073 - Neuroimmunological characterization of children suffering from psychomotor retardation due to Cytomegalovirus
infection
E. Noris- Garcia, M. Interian, D. Padron, E. Aguero, M. Gonzalez, Giselle Penton Rol;
La Havana, Cuba
422
P4.01.074 - Role of the FCGR2A Polymorphism in Susceptibility to Dengue in a Venezuelan Population
Violeta Ogando, A. Guadarrama, E.V. Salazar, M.T. Fernandez-Mestre;
Caracas, Venezuela, Bolivarian Republic of
423
P4.01.075 - Poly-γ-glutamic acid, a polypeptide secreted by Bacillus sp., induces CD14-dependent type I interferon responses
through the TLR4-MD2 complex
W. Lee, H. Cho, Jong-Won Oh;
Seoul, Korea, Republic of
424
P4.01.076 - Phosphorylation dependent 14-3-3 protein interactions in innate immune response
Tiina Öhman, S. Söderholm, P. Hintsanen, E. Välimäki, N. Lietzén, T. Aittokallio, S. Matikainen, T.A. Nyman;
Helsinki, Finland
425
P4.01.078 - Expression of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) in the human term placenta
A. Jabło ska, P. Suski, M. Studzi ska, J. Kalinka, Edyta Paradowska;
Łód , Poland
426
P4.01.079 - Immune response to Apeu virus (orthobunyavirus) infection in murine model
Paulo C. Peregrino Ferreira, A.T. Chaves, A. Bozzi, J.G. Oliveira, F.C. Costa, J.R. Santos, O.A. Martins-Filho, E.G. Kroon, R. Correa-Oliveira;
Belo Horizonte, Brazil
427
P4.01.080 - Vaccinia and Apeu virus activation of human double-negative T cells stimulated in vitro
Paulo C. Peregrino Ferreira, F.N.A. Villani, T.E. Silva, E.G. Kroon, J.G. Oliveira, O.A. Martins-Filho, R. Correa-Oliveira;
Belo Horizonte, Brazil
428
P4.01.081 - Mkk4 is not essential for negative selection but is required for optimal T cell activation and function during
acute but not chronic infection
Simon P. Preston, J.P. Cooney, M. Pellegrini;
Melbourne, Australia
429
P4.01.082 - Human APOBEC3 cytidine deaminases: not simply antiviral defense?
Ann-Mareen Räthe, T. Kehl, M. Löchelt;
Heidelberg, Germany
430
P4.01.083 - An evidence for the pathogenic role for virus-specific T cells in the mouse model of coxsackievirus B3-induced
myocarditis
A. Gangaplara, C. Massilamany, D. Steffen, A. Pattnaik, S. Huber, Jay Reddy;
Lincoln, United States
431
P4.01.084 - Effects of inoculum size on memory T cell inflation during cytomegalovirus infection
Anke Redeker, S.P.M. Welten, R. Arens;
Leiden, Netherlands
432
P4.01.085 - Investigation of ELISA and PCR for diagnosis of Infectious Mononucleosis
R.T.S.S. Roghanian, R.T.S.S. Roghanian, Rasoul T.S.S. Roghanian;
Isfahan, Iran, Islamic Republic of
433
P4.01.086 - Virus detection within leucocytes of Atlantic salmon (Salmo salar L.) by flow cytometry
Anita Rønneseth, G.T. Haugland, H.I. Wergeland;
Bergen, Norway
434
P4.01.087 - Human papillomavirus-associated induction of human β-defensins in cervical intraepithelial lesions
Cristina D. Rusanu, I. Iancu, A. Botezatu, I. Huica, G. Anton;
Bucharest, Romania
435
P4.01.088 - PD-1 induces anti-viral T cell motility paralysis: the immunological synapse perspective.
Catarina Sacristan, M. Cammer, B.H. Zinselmeyer, S. Heydari, D. Nayak, J. Herz, X. Cheng, S.J. Davis, M.L. Dustin, D.B. McGavern;
New York, United States
436
P4.01.089 - Immunologic response among adults infected by different HIV-1 Subtypes who on anti-retroviral drugs in
Northern Tanzania
Elichilia R.P.N. Shao, B.M.R. Nyombi, J.B. Sabuni;
Moshi, Tanzania, United Republic of
184
Posters - August 25
437
P4.01.090 - Development of a new generation smallpox vaccines
Sergei N. Shchelkunov, R. Maksyutov, I. Kolosova, S. Yakubitskiy, E. Gavrilova, G. Shchelkunova;
Koltsovo, Russian Federation
438
P4.01.091 - Plasticity of uterine Natural Killer cells during maternal cytomegalovirus infection
N. Jabrane-Ferrat, Johan Siewiera;
Toulouse, France
439
P4.01.093 - Severe tuberculosis is associated with a mixed (Th1, Th2, Th17) defective cytokine response to
Mycobacterium.tuberculosis antigens in children
M. Armand, V. Chhor, A. de Lauzanne, V. Guérin-El Khourouj, B. Pédron, P. Gressens, A. Faye, Ghislaine Sterkers;
Paris, France
440
P4.01.095 - Expression profiles of Toll-like receptors 1-10 in human placenta during viral infection
Patrycja Suski, J. Kalinka, M. Studzi ska, A. Jabło ska, Z. Le nikowski, E. Paradowska;
Łód , Poland
441
P4.01.096 - Blimp-1 as a major transcription factor for the generation and function of cytotoxic CD4 effector T cells (ThCTL)
Susan L. Swain, N.B. Marshall, M.D. Brauner, K. Kuang, L. Berg;
Worcester, United States
442
P4.01.097 - Chronic exposure to IFNα reduces T helper-dependent antiviral CD8+ T cell responses
Kahina Taleb, P. Villefroy, A. Hosmalin, A. Le Bon;
Paris, France
443
P4.01.098 - Differential cytokine and chemokine signatures produced by human innate immune cells after in vitro
infection with West Nile virus isolates
Andrea Teixeira-Carvalho, L.M. Espina-Gomez, C. Chancey, A. Grinev, K. Bernard, L.D. Kramer, M. Rios;
Bethesda, United States
444
P4.01.099 - Pro-apoptotic BH3-only proteins Noxa and Bim co-operate to negatively regulate CD8+ T cells during chronic
active infection
Jesse G. Toe, S.P. Preston, J.P. Cooney, H.W. Scott, G. Ebert, C.C. Allison, M. Pellegrini;
Melbourne, Australia
445
P4.01.100 - Differential Responses of Immune Cells to Type I Interferon Contribute to Host Resistance to Viral Infection
T. Baranek, T. Vu Manh, Y. Alexandre, M. Maqbool, J. Cabeza, Elena Tomasello, K. Crozat, G. Bessou, M. Dalod;
Marseille, France
446
P4.01.102 - CytoDiffTM panel allowing monitoring effectiveness of the highly active antiretroviral therapy on HIV infected
patients
Vadim E. Tseylikman, I. Reshetnikov, G. Bouvier, S. Kvyatkovskaya, S. Kvyatkovskaya, D. Faye, &. Mirkina, E. Gautherot, &. Shatirko,
E. Sukhacheva;
Chelyabinsk, Russian Federation
447
P4.01.103 - Universal influenza vaccine requires CD4 T cells for heterosubtypic protection
Sophie A. Valkenburg, O.T.W. Li, L.L.M. Poon;
Pokfulam, Hong Kong
448
P4.01.104 - BCG restores antiviral immune response in patients with recurrent respiratory papillomatosis by affecting
dendritic cell differentiation
Evelina Vetskova, T. Avramov, M. Muhtarova, T. Stefanova, M. Nikolova;
Sofia, Bulgaria
449
P4.01.105 - The influence of antibodies on the immune response to respiratory syncytial virus infection
Marloes Vissers, I. Schreurs, M.I. de Jonge, R. de Groot, G. Ferwerda;
Nijmegen, Netherlands
450
P4.01.106 - Lipopolysaccharide stimulation inhibits viral infection of human macrophages with two distinct mechanisms
Marloes Vissers, K.R. Short, P.W.M. Hermans, D.A. Diavatopoulos, G. Ferwerda;
Nijmegen, Netherlands
451
P4.01.107 - A novel RSV genetic vaccine based on chimpanzee Adenovirus and MVA vectors is safe and highly
immunogenic in animal model and fully protects cotton rats and newborn calves from RSV challenge
Alessandra Vitelli, A. Pierantoni, S. Capone, S. Colloca, A. Folgori, E. Scarselli, G. Taylor, M. Thom, R. Cortese, A. Nicosia;
Rome, Italy
452
P4.01.108 - Molecular characterization of rotavirus detected in diarrhoeic children less than five years of age in
Kano State, Nigeria
Aminu Wada-Kura, O.S. Olonitola, S. Mijatovic-Rustempasic, M.D. Esona, A.G. Abubakar, M.D. Bowen, M. Aminu;
Abuja, Nigeria
453
P4.01.109 - A Critical Role of IL-17 in Modulating B Cell Response During H5N1 Influenza Virus Infection
Xiaohui Wang, L. Lu;
Hong Kong, China
454
P4.01.110 - Early growth response genes (Egr) -2 and -3 are essential for the activation of naïve B and T cell and primary
response against virus infection
Ping Wang;
London, United Kingdom
455
P4.01.111 - Peripheral blood monocytes in acute and stable copd have impaired responses to respiratory viruses
Peter Wark, H.V. See, J. Simpson, P. Hansbro;
New Lambton, Australia
185
Posters - August 25
456
P4.01.112 - Distinct immunity between pandemic H1N1 and seasonal H3N2 influenza infections in humans
Chi-Chen Wei, L. Wang, P. Huang, K.D. Yang;
ChangHua, Taiwan
457
P4.01.113 - Role of host and viral factors in negative antibody response of seronegative occult hepatitis B virus infection
Ratna S. Wijaya, S.I. Ie, Y. A, T. Turyadi, K.E. El-Khobar, A.R. Harahap, D.H. Muljono;
Tangerang, Indonesia
458
P4.01.114 - Viral dsRNA and ssRNA analogues directly activate mast cells to cysteinyl leukotriene generation and modulate
their IgE-dependent releasability
Piotr Witczak, K. Wódz, E. B bolewska, A. Słodka, E. Brzezi ska-Błaszczyk;
Łód , Poland
459
P4.01.115 - Secondary Streptococcus pnuemoniae infection impairs the immunity to influenza virus by down-regulating the
adaptive immune response
Yuet Wu, K.H. Chow, P.L. Ho, W. Tu, Y.L. Lau;
Hong Kong, Hong Kong
460
P4.01.116 - Irreversibly skewed development of B cells towards terminal stages during HIV-1 infection and resulted in
their functional impairment
J. Yan, C. Qiu, L. Li, C. Qiu, J. Sun, J. Xu, Xiaoyan Zhang;
Shanghai, China
461
P4.01.117 - Immunological pressure by monoclonal antibodies targeting glycoproteins of the 2009 pandemic influenza
A(H1N1) virus drives quasi-species with increased virulence in mice
Hwajung Yi, M. Lee, C. Kang;
Chungcheongbuk-do, Korea, Republic of
462
P4.01.118 - Adaptive Immunity Restricts Replication of Novel Murine Astroviruses
Christine C. Yokoyama, J. Loh, G. Zhao, T.S. Stappenbeck, D. Wang, H.V. Huang, H.W. Virgin, L.B. Thackray;
Saint Louis, United States
463
P4.01.119 - Hepatitis C virus-infected cells induce down-regulation of natural killer cell activating receptors through
modulation of receptor traffic
Joo Chun Yoon, D. Choi, J. Park, J. Lee;
Seoul, Korea, Republic of
464
P4.01.120 - The roles of Interferon regulatory factor members in virus infection sensitized IDO immunomodulation
Ren-In You, S. Lo, C. Yang, M. Dai, T. Chao, Ching-Liang Chu;
Hualien, Taiwan
465
P4.01.121 - Immunogenicity of two measles-mumps-rubella vaccines in Iranian pre-school children, a randomized
controlled trial
Saeed Zarei, M. Jeddi-Tehrani, H. Zeraati, F. Pourheidari, A.A. Ferydonfar, J. Nasernia, B. Tavangar, Y. Vojgani, M.M. Akhondi, F. Shokri;
Tehran, Iran, Islamic Republic of
466
P4.01.122 - HCV-specific CD8+ T-cells are abundant in HCV-seronegatives but show private TCR repertoires
Shihong Zhang, R.K. Bakshi, P. Fytili, R. Jacobs, M.P. Manns, H. Wedemeyer, A. Kraft, M. Cornberg, V. Schlaphoff;
Hannover, Germany
467
P4.01.123 - MAP kinase phosphatase 5 targets IRF3 to regulate type I interferon production in response to influenza
infection
Yongliang Zhang, S.J. James, H. Teh, H. Takahshi;
Singapore, Singapore
468
P4.01.124 - 2009 H1N1 infection primes for strong immunological memory in human nasal-associated lymphoid tissue that
offers cross-reactive immunity to H1N1 and avian H5N1 viruses
W. Mahallawi, A. Kasbekar, M. McCormick, K. Hoschler, N. Temperton, S.C. Leong, H. Beer, F. Ferrara, P.S. McNamara, Qibo Zhang;
Liverpool, United Kingdom
469
P4.01.125 - Impact of vaccination route and chosen adjuvant on immune responses and host-pathogen interplay during
influenza infection
Vanessa Zurli, M. Taccone, M. Brazzoli, S. Gallorini, C. Galeone, A. Bonci, D. Casini, B. Baudner, S. Bertholet, A. Seubert;
Siena, Italy
P4.03 HIV PATHOGENESIS AND IMMUNITY
Session Time: Sunday, August 25, 13:20 - 15:00
470
P4.03.01 - The MHC class II transactivator CIITA inhibits HIV-1 replication in monocytic cells
G. Forlani, E. Vicenzi, S. Ghezzi, G. Poli, Roberto S. Accolla, G. Tosi;
Varese, Italy
471
P4.03.02 - Antinuclear antibodies in HIV infected Turkish patients
Ilhan Afsar, H.H. Er, A. Sener, S. Kaya;
Karabaglar/Izmir, Turkey
472
P4.03.03 - HLA-A68 and HLA-B15 Alleles are Correlated with Poor Immune Response to Highly Active Antiretroviral
Therapy among Omani AIDS Patients
Ali A. Al-Jabri, M. El-Beeli;
Muscat, Oman
473
P4.03.04 - HIV infection is associated with altered monocyte subset proportion and responsiveness to LPS stimulation
Thomas A. Angelovich, A. Maisa, J. Zhou, S.M. Crowe, P.M. Smooker, A.C. Hearps, A. Jaworowski;
Melbourne, Australia
186
Posters - August 25
474
P4.03.05 - Poor handling of bacterial antigens relate to functionally defective myeloid dendritic cells in advanced stage of
HIV infection
Sunil K. Arora, M. Sachdeva, A. Sharma;
Chandigarh, India
475
P4.03.06 - No association between TNF-α genetic variants and lipodystrophy in a population of HIV-infected patients
from South of Spain
María J. Bravo, J.D. Colmenero, M. Delgado, F. Orihuela, P. Morata, A. Alonso, A. Caballero, N. Fernández;
Málaga, Spain
476
P4.03.07 - Increased immune activation and susceptibility to HIV-1 of CD4+ T cells in children born to HIV-1 infected
women
Madeleine J. Bunders, J.L. van Hamme, M.H. Jansen, K. Boer, N.A. Kootstra, T.W. Kuijpers;
Amsterdam, Netherlands
477
P4.03.08 - Phenotypic and functional characterization of CD4 stem-cell like memory cells in rhesus macaques
Emily Cartwright, C. McGary, M. Paiardini, A. Chahroudi, G. Silvestri;
Atlanta, United States
478
P4.03.09 - Association of DC-SIGNR genotypes with dendritic cells in HIV-1 infection
Omkar Chaudhary, M. Bala, J. Singh, A. Hazarika, R. Kumar, K. Luthra;
New Delhi, India
479
P4.03.10 - Systems methodologies for understanding the pathogenesis of HIV infection
Valery A. Chereshnev;
Yekaterinburg, Russian Federation
480
P4.03.11 - Antiphospholipid antibodies in perinatally HIV infected children
Liudmyla Chernyshova, Y. Stepanovskiy, B. Dons’koi, V. Chernyshov;
Kiev, Ukraine
481
P4.03.12 - Mother-to-child anti-Nef antibody passage may protect HIV-1 vertically-infected children from AIDS disease
Guillermo Corró, S.A. Marino, C.A. Rocco;
Buenos Aires, Argentina
482
P4.03.13 - Inflammatory status in residual immunodeficiency under cART in HIV-infected patients
Rebeca S. de Pablo-Bernal, E. Ruiz-Mateos, J. Delgado, R. de la Rosa, M. Leal, S. Ferrando-Martinez;
Sevilla, Spain
483
P4.03.14 - Evaluation of Monocytes and Natural Killer cells activation, inflammatory parameters in Virologically Suppressed HIV infected Maraviroc treated patients
Chiara Dentone, A. Di Biagio, A. De Maria, G. Cenderello, P. Fraccaro, A. Parodi, A. Signori, F. Bozzano, G. Filaci, D. Fenoglio;
Genoa, Italy
484
P4.03.15 - Analysis of NKG2D ligand expression and release during HIV-1 infection: implication for NKG2D-mediated
immunosurveillance
G. Matusali, L. Vassena, E. Giuliani, Margherita Doria;
Rome, Italy
485
P4.03.16 - Presence of HIV-1 broadly neutralizing antibodies during pregnancy in relation to mother-to-child transmission
blocking
Sheron Dzoro, K. Bedi, S. Mpoloka, A. Chaillon, R. Musonda, S. Gaseitsiwe, V. Novitsky, M. Essex, F. Barin, T. Mduluza;
Gaborone, Botswana
486
P4.03.17 - A more pro-inflammatory environment is generated in nervous cells cultures in the simultaneous presence of
HIV-1 and Toxoplasma gondii, even with lower parasite replication
Edwin E. Escobar, M.A. Alfonzo;
Caracas, Venezuela, Bolivarian Republic of
487
P4.03.18 - Enhancement of NK polyfunctional cells upon TLR-7/8 activation is dependent of CD62L expression in HIV-1
exposed non-infected individuals
Josenilson Feitosa Lima, L. Mara Silva Oliveira, G. Eimi Mitsunari, A. José Silva Duarte, M. Notomi Sato;
São Paulo, Brazil
488
P4.03.19 - Diminished immune response of M1 and M2 macrophages derived from HIV+ patients
L.J. Galvão-Lima, M.S. Espindola, L.S. Soares, M.C. Cacemiro, F.A. Zambuzi, C. Fontanari, S.K. Haddad, V.R. Bollela, Fabiani G. Frantz;
Ribeirao Preto, Brazil
489
P4.03.20 - NetFCM: A tool for Automated Flow Cytometric Data Analysis
Juliet Frederiksen, M. Buggert, J. Tauriainen, A. Karlsson, O. Lund;
Lyngby, Denmark
490
P4.03.21 - Divergent immunological and virological profile between HCV viremic HIV-1-infected injection drug users and
former blood donors in China
Wenqing Geng, H. Cui, H. Sun, H. Shang;
Shenyang, China
491
P4.03.22 - Immunomodulatory effects of HIV-1 gp120 on human dendritic cells: role of STAT3/IL-6 axis
M. Del Cornò, G. Donninelli, B. Varano, A. Masotti, L. Da Sacco, Sandra Gessani;
Rome, Italy
492
P4.03.23 - Early appearance of an age-related, activated monocyte phenotype in young HIV+ individuals
Anna C. Hearps, T.A. Angelovich, A. Maisa, G.F. Lichtfuss, C. Palmer, A.L. Landay, A. Jaworowski, S.M. Crowe;
Melbourne, Australia
187
Posters - August 25
493
P4.03.24 - Lymphocytes TCD4+ and viral load in patient with premiere of aids that receive antirretroviral treatment
Dayme D. Hernandez Requejo, J.J. Perez Avila;
Habana, Cuba
494
P4.03.25 - Expression of CX3CR1 drives pro-inflammatory M-DC8+ (“slan-DC”) monocyte and NK cell accumulation into
HIV-1-infected patient spleens
S. Degrelle, C. Dutertre, S. Amraoui, J. Jourdain, K. Schaekel, B. Fabiani, L. Garderet, R. Cheynier, Y. RIchard, Anne Hosmalin;
Paris, France
495
P4.03.26 - Change of cellular immunity in patients with HIV infection and tuberculosis
Shalala H. Ibrahimova;
Baku, Azerbaijan
496
P4.03.27 - Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo
Andrea Introini, C. Vanpouille, A. Lisco, J. Grivel, L. Margolis;
Bethesda, United States
497
P4.03.28 - Cytokines found to be elevated in HIV elite controllers reduce HIV replication in vitro
Evan S. Jacobs, S.M. Keating, K. Anastos, H. Crystal, R.M. Greenblatt, A.L. Landay, E.T. Golub, J.N. Martin, S. Deeks, P.J. Norris;
San Francisco, United States
498
P4.03.29 - DRB1*01:01 gene mutation study in the second exon in patients with HIV/AIDS
Diana Kasjko, V. Jasinskis, J. Eglite, E. Dobele, L. Kovalchuka, G. Sture, L. Viksna, A. Sochnevs;
Riga, Latvia
499
P4.03.30 - Effect of HAART on reconstitution of memory versus naive T cells during tuberculosis treatment in HIV/active
pulmonary tuberculosis individuals
Sophie N. Kiyingi;
Kampala, Uganda
500
P4.03.31 - The Human Leukocyte Antigen-G 3’UTR 14-bp deletion is associated with increased CD4 T-cell recovery during
HAART in European HIV-infected women
Margit H. Larsen, L.W. Thørner, C. Erikstrup, L.H. Harritshøj, G. Kronborg, C. Pedersen, C.S. Larsen, G. Pedersen, J. Gerstoft, N. Obel;
Copenhagen, Denmark
501
P4.03.32 - Incomplete immune recovery of naïve CD4 T-cell subsets after antiretroviral treatment in HIV-1 infection
I-Na Lu, F. Ahmad, N.T. Baerlecken, R. Jacobs, R.E. Schmidt, D. Meyer-Olson;
Hannover, Germany
502
P4.03.33 - Dissociation of the nuclear pore complex during viral infection
Kazuhiko Maeda, S.A. Almofty, S.K. Singh, M.M.A. Eid, M. Shimoda, N. Sakaguchi;
Kumamoto City, Japan
503
P4.03.34 - The origin of emerged HIV after terminating anti-retroviral therapy (ART)
Jiro Matsumura, M. Shimizu, E. Shinya, S. Oka, H. Takahashi;
Tokyo, Japan
504
P4.03.35 - Viral load impact in HIV cellular immune response from children and adolescents
Tais N. Mazzola, J. Bernachi, E. Anjos, A. Longhini, R. Lemos, S. Saad, S. Costa, M. Da Silva, M. Vilela;
Campinas, Brazil
505
P4.03.36 - CCR5 expression reduces T-tropic HIV-1 strain infection by forming CD4/CXCR4/CCR5 oligomers
L. Martínez-Muñoz, R. Barroso, S.Y. Dyrhaug, G. Navarro, B. Vega, P. Lucas, S.F. Soriano, J. Rodríguez-Frade, R. Franco, Mario Mellado;
Madrid, Spain
506
P4.03.37 - T-lymphocyte/macrophage activation and HIV production upon toll-like receptor (TLRs) stimulation in naive
and HAART-treated HIV+ patients according to CD4 lymphopenia
Esther Merlini, C. Tincati, G.M. Bellistri, J. Sanchez-Martinez, G. Ancona, A. d’Arminio Monforte, G. Marchetti;
Milan, Italy
507
P4.03.38 - Platelet activation and activation of cell death pathways in platelets isolated from HIV/AIDS patients
Emersom C. Mesquita, E.D. Hottz, R.T. Amâncio, A.M. Japiassú, D.M. Medeiros, B.G.J. Grinsztejn, P.T. Bozza, F.A. Bozza;
Rio de Janeiro, Brazil
508
P4.03.39 - Differential capacity of CCR5- and CXCR4-dependent HIV-1 strains to replicate in primary cord blood CD4+ T
cells. A transcriptome analysis
Mohammad Ali Moni, S. Mariani, E. Vicenzi, G. Poli, P. Liò;
Cambridge, United Kingdom
509
P4.03.41 - Chemokine and chemokine receptor expression in HIV-infected individuals with tuberculosis on ATT and ART
Kaustuv Nayak, L. Hanna, S. Subramanyam, S. Anbalagan, S. Swaminathan;
New Delhi, India
510
P4.03.42 - DNA sensing and innate immune activation during HIV infection
Sara K. Nissen, J.F. Højen, R.K. Berg, S.R. Paludan, M. Tolstrup, M.R. Jacobsen, T.H. Mogensen;
Aarhus N, Denmark
511
P4.03.43 - Characterization of HIV-specific lymphocytes as a tool for patient management
Valentina Orlando, S. Meraviglia, E. Lo Presti, P. Di Carlo, N. Caccamo, L. Titone, F. Dieli;
Palermo, Italy
512
P4.03.45 - Development of a new multi-epitope HIV-1 tat/env/pol/gag vaccine candidate: a preliminary study
on immunogenicity
Roghaye Rahimi, M. Ebtekar, N. Arabi, M. Mahdavi;
Tehran, Iran, Islamic Republic of
188
Posters - August 25
513
P4.03.46 - Sub-optimal CD4 T-cell recovery in HIV-1 subtype C patients on antiretroviral therapy: A search for predictive
biomarkers and baseline characteristics
Gaone Retshabile, E.R. Kisanga, S. Gaseitsiwe, S. Moyo, H. Bussmann, J. Makhema, M. Essex, R. Marlink, R. Musonda;
Gaborone, Botswana
514
P4.03.47 - CD4+ T cells lacking SAMHD1 expression are highly proliferative in vivo and decrease during HIV-1 infection
Nicolas Ruffin, V. Brezar, D. Ayinde, O. Schwartz, J. Lelievre, Y. Levy, N. Seddiki;
Créteil, France
515
P4.03.48 - The HIV Tat protein favors the activation of CD8 T cells thus contributing to HIV-related immune dysfunctions
Fabio Sforza, F. Nicoli, V. Finessi, E. Gallerani, A. Caputo, R. Gavioli;
Ferrara, Italy
516
P4.03.49 - HIV-1 Nef downregulates CD1a lipid-antigen presentation in dendritic cells via hemopoietic cell kinase (HCK)
and p21 activated kinase 2 (PAK2)
Eiji Shinya, M. Shimizu, A. Owaki, L. Mori, G. De Libero, H. Takahashi;
Tokyo, Japan
517
P4.03.50 - Correlation between c-reactive protein and CD4+ cell count in HIV-infected and HIV/PTB co-infected patients at
the University of Maiduguri Teaching Hospital (UMTH), Maiduguri, Nigeria
Abdulrahman Tahir, H. Yusuph, B. Bakki, Y.B. Jibrin;
Bauchi, Nigeria
518
P4.03.51 - Manipulation of rapid apoptosis for HIV-1 gp160-specific murine CD8+ CTLs by free antigenic peptide in vivo
Hidemi Takahashi, M. Shimizu, Y. Norose, S. Takaku, M. Takahashi, Y. Nakagawa;
Tokyo, Japan
519
P4.03.52 - Immunological, hematological and biochemical parameters are changed in asymptomatic HIV-infected patients,
treated or not with antiretroviral drugs
Karen I. Tasca, C.C. de Camargo, M. Gatto, M.B. Mendes, L.R. de Souza;
Botucatu, Brazil
520
P4.03.53 - Can cytokine profiles in HIV patients be useful in clinical practice?
Karen I. Tasca, M. Gatto, C.C. Camargo, S.A. Calvi, A. Sartori, L.R. de Souza;
Botucatu, Brazil
521
P4.03.54 - Nef-HIV-1 dimerization domain plays a key role in p22-phox association and ROS modulation
Guillermo Teran-Angel, J.C. Valencia-Molina, L. Barboza, D.L. Peterson, L. Berrueta, S. Salmen;
Merida, Venezuela, Bolivarian Republic of
522
P4.03.55 - Genital epithelial cells interferon-alpha production is associated with HIV-1 infection in Beninese female
commercial sex workers
Valérie Thibodeau, A. Labbé, M. Alary, J. Poudrier, M. Roger;
Montreal, Canada
523
P4.03.56 - Membrane-binding domain from NEF-HIV-1 increases FOXP3 transcription factor expression
on human monocytes
Juan C. Valencia-Molina, G. Teran-Angel, L. Barboza, L. Berrueta, D.L. Peterson, S. Salmen;
Merida, Venezuela, Bolivarian Republic of
524
P4.03.57 - The role of immunological tolerance in humoral responses to the 2F5 epitope of HIV-1
Guang Yang, T.M. Holl, Y. Liu, T. Nojima, L. Verkoczy, J.L. VandeBerg, D. Kitamura, B. Haynes, G. Kelsoe;
Durham, United States
525
P4.03.58 - Differences in the profile of antiviral response in mothers infected by HIV-1 and newborns
Nátalli Zanete Pereira, E.C. Cardoso, G.E. Mitsunari, R.M.S.A. Ruocco, M. Zugaib, J.B. Oliveira-Filho, A.J.S. Duarte, M.N. Sato;
São Paulo, Brazil
P5.03 GENETICS OF AUTOIMMUNITY
Session Time: Sunday, August 25, 13:20 - 15:00
526
P5.03.01 - Contribution of Lewis blood group types and their genes to genetic susceptibility and autoimmune response
in Grave’s disease
Khedhir H. Ali;
Baghdad, Iraq
527
P5.03.03 - Association of LGALS3 gene polymorphism and Rheumatoid arthritis in Zahedan, southeast Iran
Mahdi Atabaki, M. Hashemi, H. Daneshvar, Z. Zakeri;
zahedan, Iran, Islamic Republic of
528
P5.03.04 - Molecular Analysis of Interleukin-17A Gene Polymorphisms in Patients with Multiple Sclerosis
Zohreh Babaloo, R. Kh. Yeganeh, E. Sakhinia, M. Farhoodi, B. Baradaran;
Tabriz, Iran, Islamic Republic of
529
P5.03.05 - Role of the GULP gene in renalglomerular macrophage phagocytosis in the autoimmune disorder Systemic
Lupus
Erythromatosus (SLE) model mice MRL/LPR mesangial cells
Hirendra N. Banerjee, A. Alikhan, C. Krauss, C. Reilly;
Kolkata, India
530
P5.03.06 - HLA DRB1-genotype in families with T1DM patients
Margarita N. Boldyreva, L. Zilberman, T. Yankevic, L. Alexeev, I. Dedov;
Moscow, Russian Federation
189
Posters - August 25
531
P5.03.07 - Epigenetic regulation of HLA class II genes and their role in autoimmune diseases
Marie Cerná, P. Cepek, M. Zajacová, A. Kotrbova-Kozak;
Prague, Czech Republic
532
P5.03.08 - Pristane-induced arthritis loci interact with Slc11a1 gene to determine susceptibility in mice selected
for high inflammation
Marcelo De Franco, M. Correa, A. Borrego, J.R. Jensen, W.H.C. Cabrera, N. Starobinas, O.G. Ribeiro, A. Galvan, T.A. Dragani,
O.M. Ibañez;
Sao Paulo, Brazil
533
P5.03.09 - Clinical relevance of typing HLA-DR7-DQ2 haplotype in celiac disease
Juan Francisco Delgado de la Poza, M. Amengual Guedán, A. Veraguas Imbernon, E. Rodríguez Sánchez, M. De los Santos de Pelegrín,
M. Guallarte Alias;
Sabadell, Spain
534
P5.03.10 - Association of BANK-1 and Cytokine gene polymorphisms with Type 1 diabetes: A family-based
and case-control study
F. Zouidi, Mouna Dkhil, H. Fourati, O. Abida, J. Costa, M. Ben Ayed, T. Kammoun, M. Hachicha, C. Penha-Gonçalves, H. Masmoudi;
Sfax, Tunisia
535
P5.03.11 - Causes of Multiple Sclerosis: a functional genomics approach
Margaret A. Jordan, J. Field, G. Foo, L. Johnson, L. Laverick, M. Gresle, T. Spelman, H. Butzkeuven, A. Baxter;
Townsville, Australia
536
P5.03.12 - Significance of single framework mutations for DNA-binding and hydrolyzing activity of antibodies from mice
with autoimmune disorders
Arina V. Kozyr, A.V. Kolesnikov, G.A. Savchenko, A.E. Khlyntseva, A.G. Bogun, I.G. Shemyakin, A.G. Gabibov;
Obolensk, Russian Federation
537
P5.03.13 - CTLA4 +49G allele in combination with HLA-DR3 associates with type 1 diabetes as well as its onset
in North Indians
Neeraj Kumar, G. Kaur, U. Kanga, N. Tandon, S.C. Zucman, N.K. Mehra;
New Delhi, India
538
P5.03.14 - TRIM39R, but not TRIM39B regulates type I interferon
Riho Kurata, A. Tajima, T. Yonezawa, H. Inoko;
Chiba, Japan
539
P5.03.15 - A “candidate-interactome” analysis of genome-wide association data in multiple sclerosis
Rosella Mechelli, R. Umeton, C. Policano, V. Annibali, G. Coarelli, V.A.G. Ricigliano, A. Fornasiero, -. IMSGC WTCCC2, G. Ristori,
M. Salvetti;
Rome, Italy
540
P5.03.16 - Immunological relations between autoimmune diseases in Thyroid Screening with Vitiligo
Vinit Mehrotra, G. Awasthi, A. Hamidy;
Dehradun, India
541
P5.03.17 - Alteration of promiscuous gene expression in the thymus is associated to susceptibility to autoimmune type 1
diabetes mellitus in mice
Ernna H. Oliveira, C. Collares, C. Macedo, E. Sakamoto-Hojo, E. Donadi, G. Passos;
Ribeirão Preto, Brazil
542
P5.03.18 - Analysis of B-cell activating factor (BAFF) gene polymorphisms (-2841 T/C, -2704 T/C, -2701 T/A, -871 C/T)
and soluble BAFF levels in primary Sjögren´s syndrome
B.A. Treviño-Talavera, C.A. Palafox-Sánchez, J.F. Muñoz-Valle, M. Vázquez-Villamar, R.E. Navarro-Hernández, G. Orozco-Barocio,
M. Vázquez-Del Mercado, Edith Oregon-Romero;
Guadalajara, Mexico
543
P5.03.19 - Interleukin-10 gene polymorphisms (-1082 A/G, -819 C/T, -592 C/A) in primary Sjögren’s syndrome
M. Vázquez-Villamar, Edith Oregon-Romero, D.C. Salazar-Camarena, B.A. Treviño-Talavera, G. Orozco-Barocio, J.F. Muñoz-Valle,
Y. Valle, C.A. Palafox-Sánchez;
Guadalajara, Mexico
544
P5.03.20 - Association between cytokine genes’ polymorphism and susceptibility to and severity of mixed connective
tissue disease (MCTD)
Agnieszka Paradowska-Gorycka, A. Felis-Giemza, M. Jurkowska, M. Olesinska;
Warsaw, Poland
545
P5.03.21 - Dysfunction of ABIN1 as genetic basis for lupus nephritis
D. Caster, E. Korte, K. McLeish, P. Gaffney, I. Adrianto, S. Nanda, P. Cohen, David Powell;
Louisville, United States
546
P5.03.22 - Neurotransmitter GABA-A MAY regulate immune system functions as detected by gene networks of peripheral
blood TCD4+, TCD8+ and CD14+ cells of recently diagnosed Type 1 Diabetes Mellitus
D.M. Rassi, A.F. Evangelista, G. Martelli-Pallomino, J.O. Crispim, I.J. Wastowski, M. Foss-Freitas, M.C. Foss, E.T. Sakamoto-Hojo,
G.A. Passos, Eduardo Antonio Donadi;
Ribeirao Preto, Brazil
547
P5.03.23 - The PRL -1149 G/T polymorphism is associated with rheumatoid arthritis and anti-CCP antibodies in Mexican population
Zyanya Reyes-Castillo, A.L. Pereira-Suárez, C.A. Palafox-Sánchez, E. Oregón-Romero, J.F. Muñoz-Valle;
Guadalajara, Jalisco, Mexico
548
P5.03.24 - Combinatorial control of Th17 and Th1 cell function by genetic variation at genes associated with the IL-23 signaling pathway in spondyloarthritis
Magda Rybczynska, M. Coffre, M. Roumier, E. Sechet, H. Law, L. Gossec, M. Dougados, E. Bianchi, L. Rogge;
Paris, France
190
Posters - August 25
549
P5.03.25 - Increased systemic autoimmunity in men with sex chromosome aneuploidy (47,XXY) reveals a X-chromosome
dosage effect
Ram R. Singh, R. Okorogu, P. Surampudi, I. Valera, C. Okereke, C. Wang, R. Swerdloff, R. Halder;
Los Angeles, United States
550
P5.03.26 - Study of programmed cell death 1 (PDCD1) genepolymorphims in Iranian patients with Ankylosing Spondylitis
Narjes Soleimanifar;
Tehran, Iran, Islamic Republic of
551
P5.03.27 - Endocrine orgam-specific autoimmunity in myasthenia gravis with thymoma related to defective function of
the autoimmune regulator (AIRE)
Anette S.B. Wolff, K. Kisand, J. Owe, N. Gilhus, M.M. Erichsen, B.E.V. Oftedal, N. Willcox, E.S. Husebye;
Bergen, Norway
552
P5.03.28 - Behçet’s Syndrome in Iranian Azari People
Fatemeh Zare Shahneh, B. Baradaran, S. Moradi, F. Hamzavi, B. Bayazi;
Tabriz, Iran, Islamic Republic of
P5.06 REGULATORY T CELLS IN AUTOIMMUNITY AND ALLERGY
Session Time: Sunday, August 25, 13:20 - 15:00
553
P5.06.01 - CD4+ T cells limit their own-pathogenicity by activating regulatory T cells by different mechanisms in different
inflammatory conditions
Audrey Baeyens, D. Saadoun, F. Billiard, Y. Grinberg-Bleyer, S. Gregoire, E. Piaggio, K. Loser, B.L. Salomon;
Paris, France
554
P5.06.02 - Role of Follicular Regulatory T cells in Multiple Sclerosis
Tessa Dhaeze, B. Broux, B. Van Wijmeersch, P. Stinissen, N. Hellings;
Diepenbeek, Belgium
555
P5.06.03 - Monocytes drive the induction of CD8+FOXP3+ regulatory T cells via the production of membrane TNF-alpha
Shawn D.P. Ellis, M.R. Ehrenstein, C.A. Notley;
London, United Kingdom
556
P5.06.04 - Diverse T-cell profiles in children with type 1 diabetes and/or celiac disease
Maria Faresjö, K. Åkesson, A. Kivling, A. Rydén;
Jönköping, Sweden
557
P5.06.05 - + Foxp3 + Treg and its ICOS + Subsets in Patients with Myocardial Infarction
Samira Ghorbani;
Isfahan, Iran, Islamic Republic of
558
P5.06.06 - Association between T cell immunoglobulin domain and mucin domain-1 gene polymorphisms with Allergic
Rhinitis patients
Hadi Hassannia, F. Hosseini, S. Abedian;
Tehran, Iran, Islamic Republic of
559
P5.06.07 - Glycogen synthase kinase-3 regulates IL-10 production in Th1 cells
Elaine V. Hill, T.H.S. Ng, D.C. Wraith;
Bristol, United Kingdom
560
P5.06.08 - Enhanced regulatory T cell function and attenuated DSS-induced colitis in the mice deficient with GPx1
and catalase
Hyung-ran Kim, H. Kim, J. Seoh;
Seoul, Korea, Republic of
561
P5.06.09 - The extrinsic factors blocking regulatory T cell function in the pathogenesis of SLE
Hyung-ran Kim, H. Kim, J. Seoh;
Seoul, Korea, Republic of
562
P5.06.10 - Targeting PAI-1 signaling results in the enhancement of iTreg and reduction of mortality in a mouse model
of septic shock
Hong H. Mu, M. Nourian, H. Jiang;
Salt Lake City, United States
563
P5.06.11 - General control nonrepressed 2 (GCN2) kinase participation in the remission phase of experimental
autoimmune encephalomyelitis (EAE) in mice
Heloisa Orsini, L. Pires, J. Maricato, B.A. Castilho, M. Mariano, A.S. Basso;
São Paulo, Brazil
564
P5.06.12 - Effect of fetal therapy on T-regulatory cells during development of experimental allergic encephalomyelitis
Ievgeniia A. Porozhan, N.N. Babenko, M.V. Ostankov, A.N. Goltsev;
Kharkov, Ukraine
565
P5.06.14 - IL-10 and NOx are associated with CD4(+)FoxP3(+) regulatory T-cell subsets in the Systemic Lupus Erythematosus
patients
Andrea A. Silva, A.L.B. Santos, N.F. Rosário, A.C.A. Pires, C. Gagliardi;
Niteroi, Brazil
566
P5.06.15 - Activin-A-induced human regulatory T cells: novel controllers of allergic asthma
Sofia Tousa, M. Semitekolou, I. Morianos, A. Banos, M. Kapasa, K. Samitas, M. Gaga, G. Paraskevopoulos, C. Hawrylowicz, G. Xanthou;
Athens, Greece
191
Posters - August 25
567
P5.06.16 - Immune regulation in lupus nephritis: role of CD4+CD25high FOXP3+ T regulatory cells and related cytokines
(IL-6, IL-10, TGFβ)
Konstantinos Tselios, A. Georgiadou, P. Klonizakis, A. Sarantopoulos, I. Gkougkourelas, M. Pantoura, P. Boura;
Thessaloniki, Greece
568
P5.06.17 - Intravenous immunoglobulin selectively enhances CD4+CD25+FOXP3+ Treg function in patients
Rogier van Gent, A.S.W. Tjon, T. Tha-In, H.J. Metselaar, L.J.W. van der Laan, Z.M.A. Groothuismink, P.A.W. te Boekhorst, M. van Hagen,
J. Kwekkeboom;
Rotterdam, Netherlands
569
P5.06.18 - Deficient differentiation of Treg cells in a murine model of Sjögren’s syndrome
Akiko Yamada, R. Arakaki, M. Kurosawa, T. Kondo, K. Yamada, Y. Kudo, Y. Hayashi, N. Ishimaru;
Tokushima, Japan
P6.07 CELL-BASED THERAPY
Session Time: Sunday, August 25, 13:20 - 15:00
570
P6.07.01 - Repeated intra-muscular injections of allogeneic mesenchymal stem cells (MSC) promote donor-specific T-cell
hypo-responsiveness but also induce allo-antibody
Senthilkumar Alagesan, M. Creane, T. O’Brien, R. Ceredig, T. Ritter, M.D. Griffin;
Galway, Ireland
571
P6.07.02 - Generation of tolerogenic monocyte-derived dendritic cells from patients with primary Sjögren’s syndrome that
suppress Ro/La specific T cell responses
R. Volchenkov, J.G. Brun, R. Jonsson, Silke Appel;
Bergen, Norway
572
P6.07.03 - Mesenchymal stem cells (MSC) modulate the expression of adhesion molecules involved in activated T-lymphocyte extravasation into the central nervous system (CNS): contribution to the therapeutic effect of MSC in inflammatory CNS
diseases?
Federica Benvenuto, L. Vergani, F. Gualandi, N. Kerlero De Rosbo, A. Uccelli;
Genoa, Italy
573
P6.07.04 - Umbilical cord blood T cells cultured with IL-7 in addition to IL-2 exhibit a higher degree of polyfunctionality
and superior proliferation potential
Sofia Berglund, J. Gertow, I. Magalhaes, J. Mattsson, M. Uhlin;
Stockholm, Sweden
574
P6.07.05 - A simple and quick method for isolation of mononuclear cells from peripheral blood and buffy coat
Sudhir Bhatia;
Duisburg, Germany
575
P6.07.06 - Altered B cell development and fuctions in Adenosine Deaminase deficient patients
Immacolata Brigida, A.V. Sauer, F. Ferrua, S. Giannelli, S. Scaramuzza, M.P. Cicalese, M. Casiraghi, E. Traggiai, M. Van der Burg, A. Aiuti;
Milan, Italy
576
P6.07.07 - The effector function of antiviral T cells in stem cell donors is strongly impaired by G-CSF mobilization
Carola Bunse, S. Borchers, S. Tischer, N. Moraw, C. Figueiredo, U. Köhl, A. Ganser, R. Blasczyk, E. Mischak-Weissinger, B. Eiz-Vesper;
Hannover, Germany
577
P6.07.09 - Overexpression of galectin-9 in islets prolongs grafts survival via downregulation of Th1 responses
Feng-Cheng Chou, C. Kuo, Y. Wang, H. Sytwu;
Taipei, Taiwan
578
P6.07.10 - T and B cell restricted MOG expression through retroviral transduction of bone marrow stem cells mediates
protection against EAE induction
Jie Y. Chung, Z. Nasa, A. Joglekar, F. Mackay, F. Alderuccio;
Melbourne, Australia
579
P6.07.11 - Intrathecal transplantation of neural stem/precursor cells hampers the CNS-confined immune response
of experimental autoimmune encephalomyelitis
Donatella De Feo, A. Merlini, C. Laterza, B. Elena, F. Ruffini, G. Martino;
Milan, Italy
580
P6.07.12 - Exploring the immunogenicity and efficacy of bone marrow-derived allogeneic cell therapy in vivo using
a humanised mouse model
Gang Feng, S. Menzies, A. Boyers, M. Rigby, A. Gutteridge, H. Fox, V. Owenson, O. Stevens, R. Deans, P. Whiting;
Cambridge UK, United Kingdom
581
P6.07.13 - Performance characterization of a novel cell processing sorter: microchip sorting without aerosols in a closed
system
J. Lee, L. Pietrzyk, E. Rodriguez-Mesa, John Foster;
Santa Barbara, United States
582
P6.07.14 - Purifying Tregs with a new closed sorter
L. Pietrzyk, J. Dunne, John Foster;
Santa Barbara, United States
583
P6.07.15 - Quality controls of Cell-Based therapies: Assessment of conditioned Dendritic Cells phenotypes by Global Gene
Expression Profiles
Maria Foti, C. Ripamonti, S. Baldassarri, J. Michalek;
Milan, Italy
192
Posters - August 25
584
P6.07.16 - Improved monitoring and generation of HAdV-specific T cells by a newly identified A*02 MHC class I multimer
and short-term in vitro expansion
René Geyeregger;
Vienna, Austria
585
P6.07.17 - Effect of myeloid-derived suppressor cells on dendritic cells maturation and function
Najmeh Khosravianfar, A. Namdar, M. Hafezi, A. Razavi, J. Hadjati;
Tehran, Iran, Islamic Republic of
586
P6.07.18 - Cloning of human antigen-specific TCRs can confer the candidates for cancer gene therapy
Eiji Kobayashi, E. Mizukoshi, H. Kishi, H. Hamana, T. Nagai, T. Ozawa, H. Nakagawa, A. Jin, S. Kaneko, A. Muraguchi;
Toyama-shi, Japan
587
P6.07.19 - A novel methodology of immune regulation using pluripotent stem cells
H. Kudo, H. Sasaki, H. Wada, S. Kojo, T. Chikaraishi, Ken-ichiro Seino;
Kawasaki Kanagawa, Japan
588
P6.07.20 - The application of in vitro expanded CD4 Th1 cells in adoptive cell therapies
Kunyu Li, F. Ronchese, M. Thorn, C. Jackson, S. Young;
Dunedin, New Zealand
589
P6.07.21 - Chondrogenic differentiation of mesenchymal stem cells alters cellular immunogenicity in vitro and in vivo
A.E. Ryan, Paul Lohan, L. O’Flynn, O. Treacy, C. Coleman, G. Shaw, M. Murphy, R. Ceredig, M.D. Griffin, T. Ritter;
Galway, Ireland
590
P6.07.22 - Migration of human mesenchymal stem cells towards inflammatory lesions after transfection
with CD29 specific siRNA
Laura Marusciac, C. Panaitescu, F. Bojin, V. Paunescu;
Timisoara, Romania
591
P6.07.23 - Treatment with EBV-Cytotoxic T-Lymphocytes of pediatric liver transplant recipients affected by EBV-related
Post-transplantation lymphoproliferative disease in early phase
Monica Miele, M. Sciveres, M. Di Bella, S. Riva, G. Amico, R. Liotta, A. Sonzogni, P. Grossi, P. Conaldi;
Palermo, Italy
592
P6.07.24 - Immune system modulation during cytokine induced killer cells adoptive therapy in hematologic patients
S. Coin, I. Cavattoni, V. Artusi, A. Pievani, I. Pusceddu, E. Tagliafico, S. Cortelazzo, A. Rambaldi, M. Introna, Vladia Monsurro;
Verona, Italy
593
P6.07.25 - Toxicity evaluation of CD44v6-specific T cells in a xenograft model that fully recapitulates human hematopoietic
development
Margherita Norelli, M. Casucci, B. Camisa, L. Falcone, G. Oliveira, A. Saudemont, C. Bordignon, F. Ciceri, C. Bonini, A. Bondanza;
Milan, Italy
594
P6.07.26 - TLR7/8 Ligand Is Necessary to Generate Potent Blast-Derived Dendritic Cells in Acute Myeloid Leukemia
Maryam Nourizadeh, F. Masoumi, A. Memarian, K. Alimoghaddam, S. Moazzeni, J. Hadjati;
Tehran, Iran, Islamic Republic of
595
P6.07.27 - Mannose-α(1→2)-Mannose derivative for dendritic cell targeted delivery
Juan S. Pappalardo, T.S. Levchenko, S. Salmaso, C.A. Langellotti, M. Vermeulen, M. Toniutti, T. Musacchio, V.P. Torchilin;
Hurlingham, BA, Argentina
596
P6.07.28 - Therapeutic effect of bone marrow-derived clonal mesenchymal stem cells in DSS-induced colitis model
J. Park, J. Kim, T. Yi, S. Song, Seok Hee Park;
Suwoan, Korea, Republic of
597
P6.07.29 - Update on IPEX syndrome: new diagnostic biomarkers and therapeutic perspectives
Laura Passerini, F. Barzaghi, E. Rossi Mel, C. Sartirana, V. Lampasona, E. Bosi, G. Fousteri, L. Naldini, M.G. Roncarolo, R. Bacchetta;
Milan, Italy
598
P6.07.30 - Investigation of mouse bone marrow Lin¯ cells regenerative properties in vitro and in vivo
Giedre Ramanauskaite, D. Zalalyte, A. Vaitkuviene, V. Kaseta, G. Biziuleviciene;
Vilnius, Lithuania
599
P6.07.31 - Promotion of corneal graft survival by donor bone marrow derived dendritic cells is mediated by creating
an intragraft immunoregulatory milieu
L. O’Flynn, O. Treacy, A.E. Ryan, M. Morcos, L. Joshi, J. Gerlach, M. Cregg, M. Nosov, Thomas Ritter;
Galway, Ireland
600
P6.07.32 - Ex vivo generation and expansion of polyclonal human Treg
E. Candia, C. Covian, F. Rodriguez, J. Morales, Mario Rosemblatt, J. Fierro;
Santiago, Chile
601
P6.07.33 - Generation of highly effective and stable murine alloreactive Tregs by combined anti-CD4 mAb, TGF-β
and RA treatment
Ulrike Schliesser, M. Chopra, A. Beilhack, S. Vogel, J. Schumann, K. Wood, H. Volk, B. Sawitzki;
Berlin, Germany
602
P6.07.34 - Generation and Characterization of WT1-specific T cells derived from healthy donors for adoptive tumor therapy
S. Schmied, Anne Richter, M. Assenmacher;
Bergisch-Gladbach, Germany
603
P6.07.35 - Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction
Michiko Shimoda, A. Bolduc, M. Takezaki, Y. Ametani, A.L. Mellor, M. Kamanaka, R.A. Flavell, T. Tsubata, P.A. Koni;
Augusta, United States
193
Posters - August 25
604
P6.07.36 - Cell therapy of cancer with alloreactive intentionally mismatched IL-2 activated donor lymphocytes targeting
anti-cancer killer NK & T cells using monoclonal and bispecific antibodies
Shimon Slavin, C. Brodie;
Tel Aviv, Israel
605
P6.07.37 - Distribution of the lymphoid cells of various functional activity after transplantation
Anastasia O. Solovieva, A.F. Poveshchenko, K.E. Zubareva, O.V. Povesh henko, V.I. Konenkov;
Novosibirsk, Russian Federation
606
P6.07.38 - Tumor associated fibroblasts are endowed with increased ability to support tumor development
Marius Toma, R.A. Lazarovicz, O. Gavriliuc, C.A. Tatu, A. Gruia, C. Tatu, G. Tanasie, C. Panaitescu, F. Bojin, V. Paunescu;
Timisoara, Romania
607
P6.07.39 - Mesenchymal stromal cell therapy prolongs corneal allograft survival in rats
Oliver Treacy, L. O’Flynn, A. Ryan, M. Morcos, M. Wilk, S. Schu, M. Cregg, M. Griffin, M. Nosov, T. Ritter;
Galway, Ireland
608
P6.07.40 - TLR5 signaling enhances the proliferation of human allogeneic CD40-activated-B-cell-induced regulatory CD4 T cells
P. Chan, J. Zheng, Y. Liu, Z. Xiang, Wenwei Tu;
Hong Kong, Hong Kong
609
P6.07.41 - Adoptive T cell therapy in patients with prostate cancer
Katerina Vavrova, K. Zurkova, R. Horvath, J. Bartunkova;
Prague, Czech Republic
610
P6.07.42 - Changes in T lymphocyte subsets accompany the clinical response to Mesenchymal Stem Cell (MSC)
therapy - first experience in irradiation-induced colitis
Jan Voswinkel, J. Lataillade, S. Francois, M. Mohty, N. Gorin, M. Benderitter, A. Chapel;
Paris, France
611
P6.07.43 - Genetically modified T cells expressing an affinity enhanced NYESO-1 T Cell Receptor in cancer therapy
Daniel D. Williams, A.P. Rapoport, E.A. Stadtmauer, G.K. Binder-Scholl, J.E. Brewer, A.D. Bennett, M. Kalos, B.L. Levine, C.H. June,
B.K. Jakobsen;
Abingdon, United Kingdom
612
P6.07.44 - Exploring leukemia- and virus-reactive CD8+ T lymphocytes with stem-cell-like and central memory properties for
effective immunotherapy in humanized mice
Yan Xu, A. Mades, S.A. Khan, M. Theobald, U.F. Hartwig;
Mainz, Germany
613
P6.07.45 - Intrapancreatic transplantation of allogeneic mesenchymal stromal cells (MSCs) decreases blood glucose levels in
experimental type 1 diabetes
Juliana N.U. Yaochite, L.S. Neto, C. Caliári-Oliveira, M.M. da Matta, K.C. Malmegrin, C.C.B.O. Menezes, D.T. Covas, J.C. Voltarelli,
E.A. Donadi;
Ribeirão Preto, Brazil
614
P6.07.46 - Generation of gene engineered mesenchymal stem cells and its efficacy against human breast cancer
Fei Ling Yap, S. Cheong, R. Ammu, C. Leong;
Bukit Jalil, Kuala Lumpur, Malaysia
615
P6.07.47 - Endothelial cells: new targets for MSCs-mediated immunomodulation in mouse
Lucia Zanotti, C. Soldani, C. Ploia, F. Moalli, E. Dander, G. D’Amico, A. Sarukhan, A. Viola;
Rozzano, Milan, Italy
616
P6.07.48 - Treatment of autoimmune hepatitis by inhibiting CD8+T cells using hepatic stroma-induced regulatory DCs
Q. Wang, D. Chen, H. He, H. Tang, W. Song, Minghui Zhang;
Beijing, China
617
P6.07.49 - Spatial distribution of transplanted bone marrow-derived mesenchymal stem cells in recipient’s organs in the B16
melanoma model
Kristina E. Zubareva, A.O. Solovieva, A.F. Povesh henko, O.B. Gritsyk, E.A. Nechaeva, V.I. Konenkov;
Novosibirsk, Russian Federation
P6.08 STEM CELLS IN IMMUNITY
Session Time: Sunday, August 25, 13:20 - 15:00
618
P6.08.01 - Comparison of immunoregulatory properties of stem cells from human exfoliated deciduous teeth and bone
marrow-derived mesenchymal stem cells
Khadijeh-minoo Adib, R. Alipour, B. Hashemi Beni;
Isfahan, Iran, Islamic Republic of
619
P6.08.02 - Production and characterization of murine monoclonal antibodies against human synthetic peptide of CD34
Leili Aghebati Maleki, J. Majidi, B. Baradaran, J. Abdolalizadeh, A. Movassaghpour;
Tabriz, Iran, Islamic Republic of
620
P6.08.03 - The effect of TNF-α in differential gene expression pattern of CXCR4 on human marrow-derived mesenchymal
stem cells
Maryam Banoo Ayatollahi, R. Ziaei, R. Yaghobi, Z. Sahraeian, B. Geramizadeh;
Shiraz, Iran, Islamic Republic of
621
P6.08.04 - Association between T Reg marker polymorphism and tuberculosis
Elham Beiranvand, S. Abediankenari, B. Beiranvand;
Tehran, Iran, Islamic Republic of
194
Posters - August 25
622
P6.08.05 - Developmental endothelial locus-1 (Del-1) is a negative regulator of GCSF-dependent hematopoietic stem cell
mobilization
Lan-Sun Chen, I. Mitroulis, N. Mende, G. Siegert, C. Waskow, G. Hajishengallis, T. Chavakis;
Dresden, Germany
623
P6.08.06 - Differential efficacy of human mesenchymal stem cells on disease in murine lupus based on source of origin
E.L. Collins, F. Gu, O. Naga, Gary Gilkeson;
Charleston, United States
624
P6.08.07 - LT-beta receptor signaling promotes progression of chronic myeloid leukemia in mice
Sabine Hoepner, C. Riether, C. Schürch, A.F. Ochsenbein;
University of Bern, Switzerland
625
P6.08.08 - In vivo imaging approach for continuous monitoring of transplanted cells
Zaruhi Karabekian, A. Popratiloff, N. Sarvazyan;
Washington, United States
626
P6.08.09 - Preparation of a high affinity monoclonal antibody against morphine showing no cross reactivity with heroin
Susan Kashanian;
Tehran, Iran, Islamic Republic of
627
P6.08.10 - Recombinant human Cyclophilin A supports differentiation of granulocytes
Ludmila M. Khromykh, N.L. Kulikova, L.Y. Grivtsova, M.A. Frenkel, N.N. . Tupitsyn, A.A. Kalinina, D.B. Kazansky;
Moscow, Russian Federation
628
P6.08.11 - Susceptibility of human cardiac progenitor cells to natural killer cell lysis
Laura Lauden, W. Boukouaci, N. Dam, N. Jabrane-Ferrat, D. Charron, R. Tamouza, R. Al-Daccak;
Paris, France
629
P6.08.12 - Properties of TiCaPCON-based nanostructured coating as bioimplant constituent
A.N. Kopilov, N.Y. Anisimova, Olga V. Lebedinskaya, D.V. Shtansky, M.V. Kiselevsky;
Perm, Russian Federation
630
P6.08.13 - Mass-production and characterization of anti-human CD34 monoclonal antibody in peritoneum of BALB/c mice
Jafar Majidi, B. Baradaran, l. Aghebati Maleki, J. Abdolalizadeh, A. Movassaghpour;
Tabriz, Iran, Islamic Republic of
631
P6.08.14 - Cell Cycle Analysis of Human Colorectal Cancer Stem Cells Reveals their Quiescent Nature
Hamid Reza R. Mirzaei, H. Mirzaei, J. Jalili, M. Eghbali, N. Bagherpour;
Tehran, Iran, Islamic Republic of
632
P6.08.15 - NF-kB rela-deficient macrophages fail to support bone formation and maintain the microenvironment
for hematopoiesis after X-ray irradiation and HSC transplanatation
Setsuko Mise-Omata, T. Fukazawa, Y. Obata, T.S. Doi;
Tsukuba, Japan
633
P6.08.16 - The effect of the Immunomodulatory functions of adipose derived mesenchymal stem cells
on the expression of major transcription factors in CD4 T cell subsets
Adel Mohammadzadeh, A. Pourfatolah, M. Soleymani, S. Moradi;
Tehran, Iran, Islamic Republic of
634
P6.08.17 - The effect of DiD on the immunosuppressive function and differentiation potency of Mesenchymal stem cells
Maryam S. Mohtasebi, F. Nasri, E. Kamali Sarvestani;
Shiraz, Iran, Islamic Republic of
635
P6.08.18 - Human mesenchymal stem cells modulation of alveolar macrophage polarization in vivo and in vitro
A.D. Krasnodembskaya, Thomas Morrison, D. McAuley, M.A. Matthay;
Belfast, United Kingdom
636
P6.08.19 - The characteristic of minor cell populations in multiple sclerosis patients after cell therapy
Darya Nizheharodava, A. Borisov, E. Nazarova, E. Rudakovskaya, M. Zafranskaya;
Minsk, Belarus
637
P6.08.20 - Immunoregulatory activity of Decidual/Endometrial Stromal Cells in humans
Carolina Reyes-Perdomo, K. Torres, M. López, P. Silva, E. García-Olivares, O. Blanco Muñoz;
Floridablanca, Colombia
638
P6.08.21 - Adipose Derived Stem Cells Isolated from Omentum: a Novel Source of Chemokines for Ovarian Cancer Growth
Somayeh Rezaeifard, M. Razmkhah, M. Robati, M. Momtahan, A. Ghaderi;
Shiraz, Iran, Islamic Republic of
639
P6.08.22 - Isolation and Characterization of Mesanchaymal Stem Cells from Mouse Decidua
Bizhan Sadighimoghadam, S. Moazzeni;
Tehran, Iran, Islamic Republic of
640
P6.08.23 - The role of p15Paf oncogene in hematopoiesis
Miloje Savic, L.K. Denzin;
New Brunswick, United States
641
P6.08.24 - Cytotoxic CD8+ T cells regulate myelopoiesis by cytokine signals to bone marrow stromal cells
Christian Schürch, C. Riether, A.F. Ochsenbein;
Bern, Switzerland
642
P6.08.25 - Large zinc finger transcrition factor Schnurri-3 functions in the osteochondroprogenitor cell to regulate bone mass
Anju Singh, C. Lester, L.H. Glimcher, D. Jones;
Rockville, United States
195
Posters - August 25
P7.02 Systems and theoretical immunology
Session Time: Sunday, August 25, 13:20 - 15:00
643
P7.02.01 - Emergence of tissue-level NF-kappaB dynamics during inflammation
Christopher R. Boddington, J. Bagnall, L. Schmidt, D.G. Spiller, D.A. Jackson, M.R.H. White, P. Paszek;
Manchester, United Kingdom
644
P7.02.02 - Cytokines prophyle in Gaucher disease type I patients with bone metabolic changes
Alexandra M. Craciun, P. Grigorescu-Sido, A. Zimmermann;
Cluj-Napoca, Romania
645
P7.02.03 - Clostridium difficile infected human signaling pathways: An integrated model
Rajat K. De, N. Tomar;
Kolkata, India
646
P7.02.04 - Systems Biology Approaches for Predicting and Controlling the Reactivity of Tumor Infiltrating Lymphocytes
Moran Hod-Marco, K. Oved, M. Besser, Y. Reiter;
Haifa, Israel
647
P7.02.05 - Utilizing next-generation sequencing of the humoral repertoire for monoclonal antibody discovery
Tarik A. Khan, A. Mirsky, S.T. Reddy;
Basel, Switzerland
648
P7.02.06 - Therapeutic Potential of Inhibition of Complement Activity for Alleviating Degenerative Eye Diseases
K. Valter, D. Garnett, J. Zhou, Girish J. Kotwal;
Camps, Saint Kitts and Nevis
649
P7.02.07 - Hgshs
Nisha Patel;
Manchester, United Kingdom
650
P7.02.08 - A new model for estimation of cell proliferation dynamics using Carboxyfluorescein succinimidyl ester (CFSE) data
Cristina Peligero, J.M. Argilaguet, W.C. Thompson, H.T. Banks, A. Meyerhans;
Barcelona, Spain
651
P7.02.09 - High-throughput antibody repertoire analysis in S. pneumoniae immunized mice
U. Haessler, M. Tamborrini, S. Cook, G. Pluschke, Sai T. Reddy;
Basel, Switzerland
652
P7.02.10 - Development of a bioinformatic framework for the study of high-throughput antibody repertoire data
S. Cook, V. Greiff, A. Mirsky, Sai T. Reddy;
Basel, Switzerland
653
P7.02.11 - Heterogenous differentiation patterns in individual CD8+ T lymphocytes
Jan C. Rohr, C. Gerlach, L. Perie, N. van Rooij, J.W.J. van Heijst, A. Velds, J. Urbanus, S.H. Naik, J.B. Beltman, H. Jacobs, R. de Boer,
T.N.M. Schumacher;
Amsterdam, Netherlands
654
P7.02.12 - Thorough characterization of TCR-pMHC binding free energy estimated by string model and Miyazawa-Jernigan matrix
Hiromichi Tsurui, S. Hirose;
Tokyo, Japan
P7.03 STRUCTURAL BIOLOGY IN IMMUNOLOGY
Session Time: Sunday, August 25, 13:20 - 15:00
655
P7.03.01 - Polyclonal T-cell Receptors recognise an unusually long tumour antigenic peptide complexed to HLA-B7
Kok-Fei Chan, S. Gras, L. Nielsen, J. McCluskey, J. Rossjohn, W. Chen;
Melbourne, Australia
656
P7.03.02 - Use of The Alcoholic Extract of Alfalfa Root Instead of SLO for ASO Diagnostic Test
Hamid Chegni, M. Oshaghi, B. Gharegozlou, B. Gharegozlou, B. Gharegozlou;
Mashhad, Iran, Islamic Republic of
657
P7.03.03 - Mapping the N- and O-glycome of mouse Peyer’s patches
Chu-Wen Cheng, S. Yu, K. Khoo;
Taipei, Taiwan
658
P7.03.04 - Disintegrin-like molecule isolated from snake venom induces endothelial cell migration and inhibits adhesion on
extracellular matrix components
I.C. Lima, J.C. Silva-Santos, M.S. Della-Casa, I.L. Santos, A. Moura-da-Silva, Patricia B. Clissa;
São Paulo, Brazil
659
P7.03.05 - Pathological Characteristic of Experimental Colorectal Cancer Model in Three Rat Strains
Shouzhi Gu, Z. Liu;
Hamamatsu, Japan
660
P7.03.06 - Ubiquitin ligase MARCH I involves peptide discrimination for MHC II complex
Yuko Kozono, R. Tanizawa, Y.C. Sasaki, S. Ishido, O. Kanagawa, H. Kozono;
Noda, Japan
661
P7.03.07 - Structural analysis of the class II HLA molecule, DP5, in complex with the Cry j 1 antigen of Japanese cedar pollen
Seisuke Kusano, M. Shirouzu, K. Yamamoto, T. Sasazuki, S. Yokoyama;
Yokohama-city, Kanagawa, Japan
196
Posters - August 25
662
P7.03.08 - Structures of the Pore-Forming Toxin Monalysin solved by X-ray crystallography and electron microscopy
Philippe Leone, C. Bebeacua, C. Kellenberger, O. Opota, B. Lemaitre, A. Roussel;
Marseille, France
663
P7.03.09 - Homology modeling of the extracellular region of the B cell protein CD19
Mark Maloney, N. Nordgren, W. Nasir, P. Nyholm;
Atlanta, United States
664
P7.03.10 - Assessing changes expression and presentation of NKG2D under the influence of serum factors in breast cancer
patients
Reyhaneh Roshani, a. khodadadi, m. Ghaforian Borujerdnia, a. Talezadeh;
ahvaz, Iran, Islamic Republic of
665
P7.03.11 - How T cells engage an EBV-associated cancer epitope
Andrea J.A. Schauenburg, J.J. Miles, E. Gostick, D.K. Cole, L. Wooldridge, S.R. Burrows, P.J. Rizkallah, A.K. Sewell, D. Prize;
Cardiff, United Kingdom
666
P7.03.12 - Human milk immunoglobulins contain various combinations of antigen-binding sites resulting
in binding polyspecificity and catalytic polyreactivity
Sergey Sedyh, V. Buneva, G. Nevinsky;
Novosibirsk, Russian Federation
667
P7.03.13 - Synergistic inhibition of Her2 overexpressing tumor cells by a combination of anti Her2 monoclonal antibodies
Fathollah Tahmasebi;
Tehran, Iran, Islamic Republic of
668
P7.03.14 - Nicotinic receptors in nervous and immune systems:identification and functional roles
Victor I. Tsetlin, I.V. Shelukhina, I.E. Kasheverov, Y.N. Utkin, M.V. Skok;
Moscow, Russian Federation
669
P7.03.15 - Rules that govern high TCR-CD3 cell surface expression
Marleen M. van Loenen, R. de Boer, R.S. Hagedoorn, E.H.M. van Egmond, M. Griffioen, J. Falkenburg, M.H.M. Heemskerk;
Leiden, Netherlands
197
Posters - August 26
Panel N°
P1.04 NKT CELLS
Session Time: Monday, August 26, 13:20 - 15:00
001
P1.04.01 - CD2/CD3/CD28 stimulation augments Granzyme B-dependent tumor clearance of Ph+ B-Acute Lymphoblastic
Leukemia by ex-vivo expanded human iNKT cells
Claudia A. Alves de Araujo, W. Luszczek, C. Calabrese, G. Neale, A. Seth, A. Pillai;
Memphis, United States
002
P1.04.02 - Interaction between iNKT and B-1 cells after P.acnes adjuvant stimulus
Liane Butin, M. Gambero, M.E. Ishimura, D. Teixeira, A.C. Keller, I.M. Longo-Maugeri;
São Paulo, Brazil
003
P1.04.03 - Phenotypic and functional dynamics of invariant Natural Killer T (CD3+6B11+iNKT) cells in patients
with tobacco-related oral carcinoma
A.K. Singh, N.K. Shukla, Satya N. Das;
New Delhi, India
004
P1.04.04 - Role of excessive thymic differentiation of RORgt+NKT17 cells in the pathogenesis of autoimmune diabetes
Caterina Di Pietro, A. Rezzonico, M. Fedeli, G. Casorati, M. Falcone;
Milan, Italy
005
P1.04.05 - Interleukin-7 Receptor α-dependent thymopoiesis regulates thymic invariant natural killer T cell retention
Michael B. Drennan, F. Pattyn, S. Govindarajan, K. De Wilde, S. Schlenner, C. Ware, S. Nedospasov, H. Rodewald, D. Elewaut;
Ghent, Belgium
006
P1.04.06 - Difluoro substituted CD1d ligands as optimal adjuvants for the priming of multifunctional CD4 T cells
Yifang Gao, B. Linclau, S. Gadola, T. Elliott, A. Williams;
Southampton, United Kingdom
007
P1.04.07 - Dynamics of iNKT cell-mediated provision of B cell help for antibody production
Yasmeen G. Ghnewa, G.S. Zeng, V.G. Lyons, D.G. Doherty;
Dublin, Ireland
008
P1.04.08 - iNKT cells can promote differentiation of B cells into cells with regulatory B cell phenotypes
Yasmeen G. Ghnewa, G.S. Zeng, V.P. O’Reilly, D.G. Doherty;
Dublin, Ireland
009
P1.04.09 - Effective stimulation of invariant natural killer T cells by oligomannose-coated liposomes
Mariko Ishii, N. Kokima;
Hiratsuka, Japan
010
P1.04.10 - Sterol carrier protein 2 is required for the maturation of iNKT cells and their stimulation by endogenous lipids
Lucia Mori, F. Facciotti, G.S. Ramanjaneyulu, R.B. Chan, M.R. Wenk, U. Seedorf, G. De Libero;
Singapore, Singapore
011
P1.04.11 - Octaarginine-modified liposomes enhance α-galactosylceramide based antitumor therapy
Takashi Nakamura, D. Yamazaki, J. Yamauchi, H. Harashima;
Sapporo, Japan
012
P1.04.12 - Roles of NKT cells in human gastric cancer
Carolina H. Ribeiro, F. Cristi, G. Pérez, K. Kramm, M. Bustamante, F. Gálvez, M. Garrido-Tapia, C.J. Hernández, J.C. Aguillón,
M.C. Molina;
Santiago, Chile
013
P1.04.13 - CD1d-restricted invariant natural killer T (iNKT) cells mediate airway inflammation through IL-25 and IL-18
Hiroshi Watarai;
Yokohama, Japan
014
P1.04.14 - Signal control of iNKT development and effector lineage differentiation
Xiaoping Zhong, S. Wang, J. Shin, J. Wu;
Durham, United States
P1.09 DENDRITIC CELL DIFFERENTIATION AND FUNCTION
Session Time: Monday, August 26, 13:20 - 15:00
015
P1.09.01 - House dust mite-sensitized myeloid dendritic cells induce reduction of allergen-specific murine airway
inflammation
Luciana Aragão-França, F. Costa, D. Athanazio, N. Alcântara Neves, L. Pontes de Carvalho;
Salvador, Brazil
016
P1.09.02 - E-cadherin contribution for Langerhans cell differentiation
Hideko Azuma, N. Mayumi, E. Watanabe, Y. Norose, E. Watari, S. Kawahara, T.B.H. Geijtenbeek, H. Takahashi;
Tokyo, Japan
017
P1.09.03 - Novel inducible immortalized dendritic cell line with entire properties of primary cells
Joanna Bandola, C. Richter, S. Thieme, M. Laugsch, K. Anastassiadis, S. Brenner;
Dresden, Germany
018
P1.09.04 - Age-associated shift in rat dendritic cell T-helper polarizing capacity
Biljana Bufan, Z. Stojic -Vukanic , N. Arsenovic -Ranin, D. Kosec, I. Pilipovic, M. Perisic , J. Ðikic , G. Leposavic ;
Belgrade, Serbia
198
Posters - August 26
019
P1.09.05 - Junctional Adhesion Molecules and Dendritic Cell Migration
S. Roh, Se Eun Byeon, C. Yoon, Y. Bae;
Suwon, Gyeonggi-do, Korea, Republic of
020
P1.09.06 - CD300 molecules as regulators of dendritic cell responses
Georgina J. Clark, R. Gasiorowski, P. Fromm, D.N.J. Hart;
Sydney, Australia
021
P1.09.07 - Human monocyte-derived dendritic cells required direct contact with natural killer cells to induce a Th1 profile
of response
Maria A. Clavijo Salomón, R.N. Ramos, G.G. Romagnoli, B. Zelante, J.A.M. Barbuto;
Sao Paulo, Brazil
022
P1.09.08 - Cytokine production by human dendritic cells treated with Brazilian propolis
Bruno J. Conti, K.B. Santiago, E.O. Cardoso, J.M. Sforcin;
Botucatu, Brazil
023
P1.09.11 - CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice
Marco Di Gioia, I. Zanoni, R. Ostuni, S. Barresi, A. Broggi, B. Costa, R. Marzi, F. Granucci;
Milan, Italy
024
P1.09.12 - Role of the Hypoxia-Inducible Factor-1alpha and Akt on hypoxia-induced migratory program in dendritic cells
Irene Filippi, C. Aldinucci, A. Pucci, S. Sozzani, F. Carraro, A. Naldini;
Siena, Italy
025
P1.09.13 - Ceramide formation is involved in Lactobacillus acidophilus-induced IFN-β response in dendritic cell
Eva Fuglsang, L. Henningsen, H. Frøkiær;
Copenhagen, Denmark
026
P1.09.15 - T300A variant of autophagy ATG16L1 gene is associated with decreased antigen sampling and processing by
dendritic cells in paediatric Crohn’s disease
C. Strisciuglio, E. Miele, M.E. Wildenberg, A. Camarca, M. Barone, A. Staiano, R. Troncone, Carmen Gianfrani;
Avellino, Italy
027
P1.09.16 - CD137 ligand generated dendritic cells are more potent than classical dendritic cells in inducing
an antigen-specific T cell response
Zulkarnain Harfuddin;
Singapore, Singapore
028
P1.09.17 - Inflammation in the periphery and dendritic cell progenitors in the bone marrow
Prue H. Hart, R.L.X. Ng, N.M. Scott, D.H. Strickland;
Perth, Australia
029
P1.09.18 - Immune dysregulation in sickle cell disease
Borys Hrinczenko, H. Mahtani, H. Rogers, R. Cleveland, L. Kass, P. Triozzi;
East Lansing, United States
030
P1.09.19 - Characterization of Monocyte-Derived Dendritic Cells able to induce an E6/E7-specific, HLA I-restricted, cytotoxic
activity
Marco Iuliano, G. Mangino, S.M. Zangrillo, V.M. Chiantore, G. Fiorucci, G. Romeo;
Latina, Italy
031
P1.09.20 - Inhibition of nitric oxide production and pro-inflammatory cytokines by several medicinal plants
Fathollah Kalantar, Z. Amirghofran, S. Malek-Hossein, H. Golmoghaddam, M. Shabani;
Shiraz, Iran, Islamic Republic of
032
P1.09.21 - Soluble TNFRp75 regulation of TNF-TNFRp55 dependent dendritic cell activation controls protective immunity
against Mycobacterium tuberculosis
Roanne S. Keeton, N. Allie, N. Hsu, P. Randall, M. Jacobs;
Cape Town, South Africa
033
P1.09.22 - SHIP-1 Expression maybe involved in the endocytic functions of early bone marrow-derived dendritic cells but
not myeloid derived suppressor cells
Ying Ying Kong, M. Fuchsberger, S. Xiang, M. Hibbs, V. Apostolopoulos, M. Plebanski;
Melbourne, Australia
034
P1.09.23 - Tofacitinib, a JAK inhibitor, induces tolerogenic phenotype in human dendritic cells
Satoshi Kubo, K. Yamaoka, S. Iwata, M. Kondo, Y. Tanaka;
Fukuoka, Japan
035
P1.09.24 - Estrogen receptor signaling and X-chromosome complement both independently contribute to the enhanced
TLR-7-mediated responses of woman plasmacytoid dendritic cells
Sophie Laffont, N. Rouquié, C. Seillet, J. Plumas, C. Aspord, J. Guéry;
Toulouse, France
036
P1.09.25 - Bovine lactoferrin induces CCL1 production in myeloid cells
Daniela Latorre, P. Puddu, P. Valenti, S. Gessani;
Bellinzona, Switzerland
037
P1.09.26 - Baicalin from Scutellaria baicalensis impairs Th1 polarization through the inhibition of dendritic cell maturation
M. Kim, Jun Sik Lee;
Gwangju, Korea, Republic of
038
P1.09.28 - LAMP-2, a novel endocytic receptor on human monocytes derived dendritic cells (MDDC).
Dario Leone;
Vienna, Austria
199
Posters - August 26
039
P1.09.29 - Role of muscarinic activation in regulation of human dendritic cells maturation process
María G. Lombardi, G. Salamone, P. Martinez Pulido, M.S. Gori, L. Ariolfo, J. Pimentel, M.E. Sales;
CABA, Argentina
040
P1.09.30 - Growth phase-dependent immune response to Staphylococcus aureus
Lisbeth D. Lund, Y. Souwer, H. Frokiar, E.C. de Jong;
Frederiksberg C, Denmark
041
P1.09.31 - ESAT-6 and HspX improve the effectiveness of Bacille Calmette-Guérin to induce human Dendritic
Cells-dependent T cells and Natural Killer cells activation
Laura Marongiu, M. Donini, L. Toffali, E. Zenaro, S. Dusi;
Verona, Italy
042
P1.09.32 - Dendritic cell CCAAT/ enhancer binding protein delta modulates Th17/Treg responses in an IL-10 dependent manner
Mohammad G. Mohammad, V.W.W. Tsai, S.N. Breit, P.E. Sawchenko, D.A. Brown;
Sydney, Australia
043
P1.09.33 - Study of leukemic cell products and IL-1β as modulators of human dendritic cells
Juliana M. Motta, A. Sperandio, M.T.L. Castelo-Branco, V.M. Rumjanek;
Rio de Janeiro, Brazil
044
P1.09.34 - Evaluation of the effect of the 14kDa protein isolated from aged garlic extract on dendritic cells
Hasan Namdar Ahmadabad, M. Zuhair, M. Nezafat Firizi;
Tehran, Iran, Islamic Republic of
045
P1.09.35 - IL-1 and IL-1 Receptor Antagonist Genes Polymorphism in ACPA Positive Rheumatoid Arthritis Patients
Nardjess Ouikhlef, I. Allam, N. Raaf, A. Abdessamed, N. Bahaz, A. Tahiat, K. Cherguelaine, A. Ladjouze, R. DjiDjik, M. Ghaffor;
Algiers, Algeria
046
P1.09.37 - Dendritic cell reprogramming by endogenously produced lactic acid
A. Nasi, T. Fekete, A. Krishnamurthy, S. Snowden, É. Rajnavölgyi, A.G. Rothfuchs, A.I. Catrina, C.E. Wheelock, N. Vivar, Bence Rethi;
Stockholm, Sweden
047
P1.09.38 - CD1c+ DCs are superior at stimulating Th2 cytokine production upon grass pollen stimulation compared
to circulating basophils and pDCs
Frida Rydnert, K. Lundberg, L. Greiff, M. Lindstedt;
Lund, Sweden
048
P1.09.39 - Absence of Estrogen Receptor Alpha Reduces the Number and Function of Bone Marrow derived PDCA1+ cells
in Lupus Prone Mice
Jennifer L. Scott, G.S. Gilkeson, M. Cunningham, O. Naga;
Charleston, United States
049
P1.09.40 - Endogenous production of activin A acts as negative regulator of NK-DC functional interactions
Pascal Seeger, D. Bosisio, S. Parolini, R. Badolato, A. Gismondi, A. Santoni, S. Sozzani;
Brescia, Italy
050
P1.09.41 - CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3 and Batf3
Cyril Seillet, J.T. Jackson, K.A. Markey, G.R. Hill, K.P.A. MacDonald, S.L. Nutt, G.T. Belz;
Melbourne, Australia
051
P1.09.42 - β2 adrenergic receptor-mediated IL12p70 suppression in LPS-activated dendritic cells is IL-10and PKA-independent
Maisa C.S. Takenaka, J.T. Maricato, V.M. Nascimento, M.G. Guereschi, L.P. Araujo, A.S. Basso;
São Paulo, Brazil
052
P1.09.43 - Monocyte-derived dendritic cells pre-treated with TLR-3 and TLR-7 agonists express functional stability
and Th17 polarization capacity in response to tumor conditioned media from colorectal cancer patients
Sasa Vasilijic, D. Vucevic, I. Rajkovic, Z. Kostic, S. Jankovic, D. Mikic, M. Colic;
Belgrade, Serbia
053
P1.09.44 - Agonistic anti-4-1BB mAb promotes the maturation and activation of hypoxic dendritic cells
Qun Wang, C. Liu, Z. Dong, C. Guo, L. Zhang;
Jinan, China
054
P1.09.45 - The equivalents of human blood and spleen DC subtypes can be generated in vitro from human CD34+ stem
cells in the presence of Flt3L and TPO
Li Wu, A. Proietto, D. Mittag;
Beijing, China
055
P1.09.46 - Stat6 in dendritic cells negatively regulate IL-10 production and enhance arthritis
Kunihiro Yamaoka, S. Kubo, M. Kondo, K. Maeshima, K. Nakano, K. Oshita, Y. Tanaka;
Kitakyushu, Japan
056
P1.09.47 - PU.1 regulates CCR7 expression in dendritic cells
Takuya Yashiro, M. Hara, K. Okumura, C. Nishiyama;
Bunkyo-ku, Tokyo, Japan
057
P1.09.48 - Specialized role of skin dendritic cell subsets in induction of antigen-specific cellular and humoral immunity
following intradermal vaccination
Marija Zaric, O. Lyubomska, C. Scott, R. Donnelly, A. Kissenpfennig;
Belfast, United Kingdom
058
P1.09.49 - Unique features of sublingual mucosal dendritic cells after antigen application
Chenyang Zhang, T. Ohno, M. Azuma;
Tokyo, Japan
200
Posters - August 26
P2.05 IMMUNE RESPONSES IN AGING
Session Time: Monday, August 26, 13:20 - 15:00
059
P2.05.01 - How M. leprae Hsp65 influences the immune response in genetically selected aged mice?
Estevam J. Baldon, E.B. Marengo, V. Bueno, M. De Franco, O.A. Sant’Anna;
São Paulo, Brazil
060
P2.05.02 - Interferon signaling pathway: Intrahepatic expression of STAT 1 and interferon resistance in HCV patients
Qudsia Bashir, A. Rashid, A. Naveed, R.S.A. Khan, S. Razak;
Islamabad, Pakistan
061
P2.05.03 - Impact of Cytomegalovirus seropositivity on the lymphocytes counts in middle age individuals: increase of
CD4+CD62L-CD28- lymphocytes in a sub-group of CMV+ individuals
P. Apoil, B. Puissant-Lubrano, N. Congy-Jolivet, M. Peres, D. Bloom, F. Roubinet, Antoine Blancher;
Toulouse, France
062
P2.05.04 - Reduced naïve CD8+ T-cell priming capacity in elderly and HIV infected individuals
Olivia Y. Briceño, A. Lissina, G. Afonso, E. Gostick, D. Price, C. Katlama, U. Karrer, R. Mallone, D. Sauce, V. Appay;
Paris, France
063
P2.05.05 - Is angiotensin-I converting enzyme (ACE) associated with immunosenescence?
M.E. Ishimura, B. Viniauskas, D. Teixeira, J. Chagas, I.M. Longo-Maugeri, Valquiria Bueno;
São Paulo, Brazil
064
P2.05.06 - SRC homology 2 domain-containing phosphatase-1 (SHP-1) is a negative T cell regulator of T lymphocyte
responses associated with aging
Tamas Fulop, A. Le Page, H. Garneau, N. Allard, K. Tsvetkova, A. Larbi, C. Fortin, G. Dupuis;
Sherbrooke, Canada
065
P2.05.07 - MF59-induced ATP-signaling pathway is not impaired by immunosenescence thereby contributing to an efficient
adjuvant activity in the elderly
Marilena Gallotta, M. Taccone, M. Tortoli, M. Vono, A. Bonci, D. Casini, S. Bertholet, E. De Gregorio, D.T. O’Hagan, A. Seubert;
Siena, Italy
066
P2.05.08 - The significance of thymic involution and the function of re-entryed T cells in thymus
Yanan Gao, X. Pei, Y. Zhang;
Beijing, China
067
P2.05.09 - Targeting macrophages rescues age-related immune deficiencies in geriatric mice
Connie Jackaman, H.G. Radley-Crabb, Z. Soffe, T. Shavlakadze, M.D. Grounds, D.J. Nelson;
Bentley, Australia
068
P2.05.11 - Crucial role of Menin in the regulation of CD4 T cell immunosenescence
Makoto Kuwahara, T. Nakayama, M. Yamashita;
Kisarazu-shi, Japan
069
P2.05.12 - Gender specific immune status differences in children and adults
Julia Lagereva, S. Belyaeva;
Ekaterinburg, Russian Federation
070
P2.05.13 - Lipid laden multilocular cells in the aging thymus are phenotypically heterogeneous
Larissa G.P. Langhi, L.R. Andrade, M.K. Shimabukuro, D.D. Taub, R. Borojevic, V. de Mello-Coelho;
Rio de Janeiro, Brazil
071
P2.05.14 - Ageing impairs macrophage phagocytosis: impact of altered cellular microenvironment?
Eimear Linehan, D.C. Fitzgerald;
Belfast, United Kingdom
072
P2.05.15 - The effect of anti-CMV response differs in nonagenarians and young controls: a transcriptomic analysis
Saara Marttila, J. Jylhävä, M. Jylhä, A. Hervonen, M. Hurme;
Tampere, Finland
073
P2.05.16 - Fetal microchimerism induces positive effects on the immune system of elderly individuals
Tapio Nevalainen, J. Jylhävä, S. Marttila, T. Kuparinen, M. Jylhä, A. Hervonen, M. Hurme;
Tampere, Finland
074
P2.05.17 - Bone marrow T cells from the femur are similar to iliac crest derived cells in old age and represent a useful tool
for studying the aged immune system
Theresa Pritz, K. Landgraf-Rauf, D. Herndler-Brandstetter, R. Rauf, J. Lair, R. Gassner, B. Weinberger, M. Krismer,
B. Grubeck-Loebenstein;
Innsbruck, Austria
075
P2.05.18 - Association analysis between CTLA-4 polymorphisms and bipolar disorder
Alireza Rafiei, Z. Hosseini Khah, M. Taheri, S. Hosseini, M. Vesali;
Sari, Iran, Islamic Republic of
076
P2.05.19 - Survival, proapoptotic proteins and TNFR induced in senil cataract
Atzin Robles-Contreras, M. Arredondo-Flores, J.L. Oliva-Ramirez, C. Palacio-Pastrana, L.L. Arroyo, O. Guerrero-Berguer,
H.J. Perez-Cano;
Mexico city, Mexico
077
P2.05.20 - CMV infection associates to the expansion of polyfunctional CD8+CD57+ T cells in young individuals
A. Pera, C. Campos, B. Sanchez-Correa, C. Alonso, R. Tarazona, Rafael Solana;
Cordoba, Spain
201
Posters - August 26
078
P2.05.21 - Association between early development of cellular immunity to cytomegalovirus and Graft-Versus Leukemia
effect in pediatric transplantation
V. Guérin-El Khourouj, R. Porcher, S. Leveillé, J. LeGoff, B. Pédron, A. Baruchel, J. Dalle, Ghislaine Sterkers;
Paris, France
079
P2.05.22 - Age influences the systemic inflammatory response in patients with community-acquired pneumonia
Lonneke A. van Vught, H. Endeman, S.C.A. Meijvis, B.P. Scicluna, A.H. Zwinderman, D.H. Biesma, T. van der Poll;
Amsterdam, Netherlands
080
P2.05.23 - Age-related changes in cell surface markers of BALB/C mice: A flow cytometric analysis
Emine Yavuz, S. Hasgur, E.U. Bagriacik;
Ankara, Turkey
081
P2.05.24 - irradiation indeces immune modification in splenocytes
Yasuhiro Yoshida, Y. Song, R. Okazaki, T. Kanazawa;
Kitakyushu, Japan
082
P2.05.25 - Cytomegalovirus infection impacts the development of CD4 memory T cells in young individuals
Zdenek Zadrazil, A. Larbi, A. Vasudev;
Singapore, Singapore
P2.08 ANTIGEN RECEPTOR SIGNALING
Session Time: Monday, August 26, 13:20 - 15:00
083
P2.08.01 - Functional relevance of NTAL adaptor cleavage
M.M. Arbulo-Echeverria, F.J. Garcia-Cozar, Enrique Aguado;
Cadiz, Spain
084
P2.08.02 - Analysis of TCR-Vβ repertoire in lung and blood lymphocytes of pulmonary sarcoidosis patients reveals presence
of CD4+ and CD8+ T cell expansions
Kerstin M. Ahlgren, T. Ruckdeschel, A. Eklund, J. Wahlström, J. Grunewald;
Stockholm, Sweden
085
P2.08.03 - The contribution of ligand affinity of the inhibitory coreceptor ILT2 to differential patterning of TCR at the immune
synapse
Mina O. Aletrari, K. Sabaratnam, R. Zhang, S. Dyball, S. Seyedmohammad, M. Purbhoo;
London, United Kingdom
086
P2.08.04 - Tollip-induced down-regulation of MARCH1
Marie-Claude Bourgeois-Daigneault, A. Pezeshki, T. Galbas, M. Houde, M. Baril, K. Früh, A. Amrani, S. Ishido, D. Lamarre,
J. Thibodeau;
Montreal, Canada
087
P2.08.05 - Intrinsic binding of V genes to autoantigens may contribute to BCR repertoire
A.Q. Maranhão, B.W. Costa, P.M.M. Vieira, L. Guedes, M.E.T. Walter, T. Raiol, Marcelo M. Brigido;
Brasilia, Brazil
088
P2.08.06 - PAG (Cbp) as a positive reulator of mast cell signaling
Viktor Bugajev, L. Dráberová, M. Machyna, P. Dráber;
Prague 4, Czech Republic
089
P2.08.07 - The phosphatase JKAP inhibits T-cell receptor signaling and autoimmunity by inactivating Lck
Huai-Chia Chuang, J. Li, J. Lan, D. Chen, C. Yang, J.W. Belmont, T. Tan;
Zhunan Miaoli County, Taiwan
090
P2.08.09 - Higher sensitivity of restored human CD8 T-cells to virus- and tumor-derived antigens
Julia Fischer, S. Stevanovic, G. Grigoleit, T. Hünig;
Würzburg, Germany
091
P2.08.10 - Regulation of AP-1 activation in T cells by EGR-2
Emma L.M. Ghaffari, T. Miao, A.L.J. Symonds, P.K. Bhullar, S. Li, P. Wang;
London, United Kingdom
092
P2.08.11 - VAV1 controls inflammation in Experimental Autoimmune Encephalomyelitis (EAE)
Andre O. Guerreiro-Cacais, M. N’Diaye, R. Berglund, A.D. Beyeen, M. Jagodic, T. Olsson;
Stockholm, Sweden
093
P2.08.12 - Phage mini-antibodies and their use for detection of microbial cells by using electro-optical sensor
Olga I. Guliy, l. Dykman, S. Staroverov, V. Bunin, O. Ignatov;
Saratov, Russian Federation
094
P2.08.13 - Cdc42 controls cytokine secretion at the immune synapse
Claire Hivroz, A. Bohineust, K. Chemin, S. Dogniaux, S. Guegan;
Paris, France
095
P2.08.14 - OCILRP2 costimulates T cell activation by activating MAPK signaling pathway
Yanzhong Hu;
Kaifeng, Henan, China
096
P2.08.15 - Generation of LYPLA1 knockout Jurkat T cells by transcription activator-like effector nuclease (TALEN) technology
D. Biedenweg, U. Jehmlich, A. Alahmad, Matthias Hundt;
Greifswald, Germany
202
Posters - August 26
097
P2.08.18 - A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction
of lysosomal-associated protein transmembrane 5
Yohei Kawano, R. Ouchida, J. Wang, S. Yoshikawa, D. Kitamura, H. Karasuyama;
Tokyo, Japan
098
P2.08.19 - Detection of antigen-stimulated cytokine-secretion in human T-cells at single cell levels on a live cell chip
Hiroyuki Kishi, A. Jin, H. Hamana, K. Tajiri, S. Hatakeyama, E. Kobayashi, T. Ozawa, T. Nagai, A. Muraguchi;
Toyama, Japan
099
P2.08.20 - Recombinant P. aeruginosa outer membrane proteins and immune response
A.V. Soldatenkova, L.A. Geiderova, E.A. Akhmatov, N.A. Mikhailova, N.K. Akhmatova, Olga V. Lebedinskaya;
Perm, Russian Federation
100
P2.08.21 - Lck Mediates Signal Transmission from CD59 to the TCR/CD3 Pathway in Jurkat T Cells
Anna M. Lipp, K. Juhasz, C. Paar, C. Ogris, P. Eckerstorfer, R. Thuenauer, J. Hesse, H. Stockinger, G.J. Schütz, U. Bodenhofer, Z. Balogi,
A. Sonnleitner;
Linz, Austria
101
P2.08.22 - The initiation of B cell receptor signaling is sensitive to the stiffness properties of the substrate presenting the
antigens
Wanli Liu, Z. Wan;
Beijing, China
102
P2.08.23 - C-type lectin related protein OCILRP2 enhances development and functional differentiation of mouse bone
marrow-derived dendritic cells
Yuanfang Ma;
Kaifeng, Henan China, China
103
P2.08.24 - Inhibition of PI3K/Akt pathway in antigen-stimulated B-lymphocytes and hybridoma cells induces their apoptotic
death
Yana Malyutina, Y. Makarova, A. Kabakov;
Obninsk, Russian Federation
104
P2.08.25 - The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling
Pieta K. Mattila, C. Feest, D. Depoil, B. Treanor, B. Montaner, K.L. Otipoby, R. Carter, L.B. Justement, A. Bruckbauer, F.D. Batista;
Turku, Finland
105
P2.08.26 - CD22 ligand-binding and signalling domains reciprocally regulate B-cell Ca2+ signalling
Jennifer Müller, I. Obermeier, M. Wöhner, C. Brandl, S. Mrotzek, P. Maity, M. Reth, L. Nitschke;
Erlangen, Germany
106
P2.08.27 - Germline TSC1 mutations are permissive for T lymphocyte development and homeostasis in Tuberous Sclerosis
individuals
Karolina Pilipow, V. Basso, N. Migone, A. Mondino;
Milan, Italy
107
P2.08.28 - Ligation of human Fc receptor like-2 (FCRL2) by specific monoclonal antibodies downregulates B cell receptor
mediated signaling
Mahdi Shabani, A.A. Bayat, M. Jeddi-Tehrani, H. Rabbani, C. Ulivieri, Z. Amirghofran, C.T. Baldari, F. Shokri;
Tehran, Iran, Islamic Republic of
108
P2.08.29 - Cell membrane permeable phosphopeptides of Gab1 inhibit signaling in B cells by interacting with SHP-2
phosphatase
Eszter Szarka, Á. Kertész, J. Varga, Á.S. Garai, G. Gógl, A. Reményi, T. Janáky, G. Váradi, G. Tóth, G. Sármay;
Budapest, Hungary
109
P2.08.30 - Perturbing human TCR signaling pathway through superantigen from Staphylococcus aureus: Multi objective
optimization under FBA
Namrata Tomar, R.K. De;
Kolkata, India
110
P2.08.31 - Suppression of T cells proliferation by A novel generated monoclonal antibody, COS3A
Siriwan Wansook, S. Pata, K. Mahasongkram, W. Kasinrerk, P. Khunkaewla;
Nakhonratchasima, Thailand
P2.12 SIGNALLING IN IMMUNE CELLS
Session Time: Monday, August 26, 13:20 - 15:00
111
P2.12.01 - Symmetry breaking in reconstituted actin cortices
Enas Abu Shah, K. Keren;
Haifa, Israel
112
P2.12.03 - Identification of signalling cascades during the inflammatory activation of phagocytes induced by S100A8
and S100A9
Selina Fassl, J. Austermann, M. Riemenschneider, A. Witten, M. Stoll, J. Roth, T. Vogl;
Muenster, Germany
113
P2.12.04 - Type-1 serine/threonine phosphatases and PI3K signaling contribute for the TLR antagonist effect of Natterins
Marcio José Ferreira, C. Lima, M. Lopes-Ferreira;
São Paulo, Brazil
114
P2.12.05 - T cell proliferation defect of DiGeorge syndrome patients is associated with impaired CrKL signaling
Mauro Giacomelli, R. Kumar, A. Prandini, A. Soresina, D. Moratto, S. Negri, O. Scomodon, A. Plebani, R. Badolato;
Brescia, Italy
203
Posters - August 26
115
P2.12.06 - CD38/CD203a/CD73 runs in human T lymphocytes a novel adenosinergic loop independent from CD39
Alberto L. Horenstein, A. Chillemi, G. Zaccarello, V. Quarona, A. Zito, F. Malavasi;
Turin, Italy
116
P2.12.07 - Genetically engineered chimeric molecules targeting Influenza A viral antigen
Iva I. Ivanova, N. Mihaylova, N. Kerekov, A. Erdei, J. Prechl, A. Tchorbanov;
Sofia, Bulgaria
117
P2.12.08 - Experimental and computational study of ROS and RNS in endothelial and leukocyte interactions
Mahendra Kavdia, J. Chen, S. Kar;
Detroit, United States
118
P2.12.09 - Arhgap12 as a novel binding partner of GULP regulates Rac1 activity during Stablin-2-mediated cell corpse engulfment
Sang-Yeob Kim, D. Bae, S. Kim, H. Choi, J. Pyo, S. Park, I. Kim;
Seoul, Korea, Republic of
119
P2.12.10 - Acetylation modulates Interleukin-2 receptor signaling
Taku Kuwabara, M. Kondo;
Ota-ku, Tokyo, Japan
120
P2.12.11 - Galphai2 and Galphai3 differentially regulate arrest and chemotaxis in neutrophils
Yoshihiro Kuwano, M. Adler, H. Zhang, A. Groisman, K. Ley;
Tokyo, Japan
121
P2.12.12 - RUNX transcription factors regulate the transcriptional activity of CD69
Teresa Laguna, L. Notario, P. Lauzurica;
Majadahonda, Spain
122
P2.12.14 - The late endosomal transporter CD222 spatially regulates the distribution of proximal T cell signaling molecules
Vladimir Leksa, K. Pfisterer, F. Forster, W. Paster, V. Supper, P. Eckerstorfer, C. Donner, H. Stockinger;
Vienna, Austria
123
P2.12.15 - The activation and co-stimulatory functions of Fc receptor like 1 protein (FcRL1) in human B cells depend on
phosphatidylinositol 3-kinase
Chuen-Miin Leu, Y. Chen, T. Hsieh, G.R.A.A. Ehrhardt, M.D. Cooper;
Taipei City, Taiwan
124
P2.12.16 - Sterile alpha motif (SAM) and individual H5 alpha helix mediates SLP-76 oligomer formation for microclusters
and T-cell activation
Hebin Liu, Y. Thaker, L. Stagg, H. Schneider, J. Ladbury, C.E. Rudd;
SuZhou, China
125
P2.12.17 - Functionally Relevant phoshorylatable Serine Clusters targeted by Casein Kinase 2 on the Cytoplasmic region of
the human CD6 Lymphocyte Surface Receptor
L. Bonet, M. Farnós, M. Martínez-Florensa, V.G. Martinez, Francisco Lozano;
Barcelona, Spain
126
P2.12.18 - Targeted mitochondrial antioxidant SkQ has anti-inflammatory properties in vitro and in vivo
Alexander Lukashev, M. Skulachev;
Moscow, Russian Federation
127
P2.12.19 - SAP-mediated inhibition of Diacylglycerol kinase alpha regulates TCR-induced diacylglycerol signaling
and restimulation induced cell death in XLP patients
G. Baldanzi, E. Ruffo, Valeria Malacarne, K.E. Nichols, L. Patrussi, C.T. Baldari, A. Snow, A. Graziani;
Novara, Italy
128
P2.12.21 - The influence of calpain-calpastatin system in human lymphocyte - assessment of lymphocyte signaling process
of centenarians and elderly people
Anna Mikosik, A. Jasiulewicz, J. Frackowiak, J. Foerster, D. Schetz, J.M. Witkowski;
Gdansk, Poland
129
P2.12.22 - CD157-extracellular matrix proteins interactions enhance integrin-mediated signalling cascade in monocytes
Simona Morone, A. Giacomino, R. Parrotta, N. Lo Buono, M. Cuccioloni, E. Ortolan, A. Funaro;
Torino, Italy
130
P2.12.23 - IL-21 isoform is a membrane-bound ligand and activates directly interacted cells
Hidetoshi Nara, M. Rahman, A. Araki, L. Jin, Y. Takeda, H. Asao;
Yamagata City, Japan
131
P2.12.24 - Differential TLR1/2 pro-inflammatory signaling during the first 9 months of life
Elisa Nemes, M. Shey, W. Whatney, C. Riou, T. Scriba, W. Hanekom;
Cape Town, South Africa
132
P2.12.25 - Dasatinib leads to a reduced number of B cells in mice and promotes apoptosis of human CD19+ peripheral blood
B cells
Morten P. Oksvold, C.B.F. Thien, S.A. Dagger, L. Forfang, J.H. Myklebust, E.B. Smeland, W.Y. Langdon;
Oslo, Norway
133
P2.12.26 - Regulation of TCR trafficking and immune synapse assembly by Rab29
Anna Onnis, S. Spanò, F. Finetti, L. Patrussi, J.E. Galan, C.T. Baldari;
Siena, Italy
134
P2.12.27 - A mutation in the moesin gene induces an alteration of T lymphocyte adhesion/migration process in a new
combined immunodeficiency syndrome
Farid Ouchani, C. Lagresle, S. Luce, K. Jacobs, C. Picard, A. Fischer, G. De Saint Basile, N. Jabado, M. Cavazzana-Calvo, I. André-Schmutz;
Paris, France
204
Posters - August 26
135
P2.12.28 - Characterization of THEMIS as a novel attenuator of TCR signalling
Wolfgang Paster, A. Bruger, C. Brockmeyer, G. Fu, A. Kabat, C. Wuelfing, N.R.J. Gascoigne, O. Acuto;
Oxford, United Kingdom
136
P2.12.30 - Platelets and leukocytes reactivity in patients with ischemic stroke
Iryna Prylutska, E. Barinov, O. Sulaieva, A. Kit;
Donetsk, Ukraine
137
P2.12.31 - The chicken IFN- λ Receptor Complex
Andreas Rohringer, K. Goossens, A. Ward, A. Bean;
Geelong, Australia
138
P2.12.32 - A novel tool to isolate and analyze lipid rafts
Philipp Schatzlmaier, J. Huppa, H. Stockinger;
Vienna, Austria
139
P2.12.34 - IL-10 receptor and endoplasmic reticulum stress impairs STAT3 activation in type 1 diabetes patients and their
healthy first degree relatives
Mamdouh A.K. Sedhom, A. Cotterill, K. Irvine, R. Thomas;
Woolloongabba, Brisbane, QLD, Australia
140
P2.12.35 - Enhanced expression of adenosine-producing ectonucleotidases in activated and memory T cells
Ivan Shevchenko, A.V. Bazhin, V. Umansky;
Heidelberg, Germany
141
P2.12.36 - Phenotypical analysis of transgenic mice expressing soluble human CD6 supports an immunomodulatory role
for this protein
Inês T. Simões, V.G. Martinez, R. Fenutría, J. Alberola-Ila, F. Lozano;
Barcelona, Spain
142
P2.12.37 - Understanding signalling requirements of LTi cells in vivo and in vitro
J. Wagner, Gleb Turchinovich, D. Finke;
Basel, Switzerland
143
P2.12.38 - Elucidation of IL-17 signaling pathways
Evgeny Varfolomeev, D. Vucic;
South San Francisco, United States
144
P2.12.39 - Biological evaluation of human PBMC and Th17 cells using MILLIPLEX® MAP cell signaling and cytokine panels
J. Hwang, T. Warmke, R. Keith, Rick Wiese;
St Charles, United States
145
P3.08.26 - Bromodomain-Containing-Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation
in Human CD4+ T Cells
Joe, poh sheng Yeong, W. Zhang, P. Celine, C. Sum, N. Thiessen, S. Jones, S. Pettersson, S. Knapp, H. Yang, K. Chin;
Singapore, Singapore
P3.06 COSTIMULATION
Session Time: Monday, August 26, 13:20 - 15:00
146
P3.06.01 - The effect of a high intensity interval exercise on the proliferative response of lymphocytes
R. Tossige-Gomes, Karine Beatriz Costa, S.M. Magalhães, V.O. Ottone, F.C. Magalhães, F.T. Amorim, E. Rocha-Vieira;
Diamantina, Brazil
147
P3.06.02 - Regulatory T cells control Th1 priming by inhibiting the CD70/CD27 pathway
Maxime Dhainaut, C. Coquerelle, S. Uzureau, V. Acolty, J. Denoeud, G. Oldenhove, E. Pays, M. Moser;
Gosselies, Belgium
148
P3.06.03 - XCR1 promotes the activation of CD8+ T lymphocytes by optimizing their interaction with CD8a+ dendritic cells
Sonia Ghilas, K. Crozat, M. Dalod;
Marseille, France
149
P3.06.04 - The Inducible Costimulator (ICOS) facilitates interleukin-4 synthesis through phosphoinositide 3-kinase signaling
Mathieu Gigoux, A. Lovato, J. Leung, J. Leconte, N. Sonenberg, W. Suh;
Montréal, Canada
150
P3.06.05 - Discovery of a novel immune checkpoint regulator of the B7 family that negatively modulates T cell activation
Iris Hecht, J.R. Podojil, K. McNamee, I. Vaknin, A. Oren, A. Toporik, G. Cojocaru, G. Rotman, R. Williams, S.D. Miller;
Tel Aviv, Israel
151
P3.06.06 - Nucleic acid-mediated T cell activation through a novel sensing mechanism induces Th2 responses
Takayuki Imanishi, S. Akira, T. Saito;
Yokohama, Japan
152
P3.06.07 - Semaphorin 4A regulates activation of CD8+ T cells
Daisuke Ito, S. Nojima, A. Kumanogoh;
Suita city, Japan
153
P3.06.08 - CD28 costimulates the CD4+ T cell tolerogenic response to exogenous antigen in vivo
A. Jaekel, E. Mettke, Nele Reeg, Y. Yang, A. Hutloff, H. Mages, S. Gurka, R. Kroczek;
Berlin, Germany
154
P3.06.09 - TIM-3 does not act as a receptor for galectin-9
Judith Leitner, K. Grabmeier-Pfistershammer, A. Rieger, W.F. Pickl, G. Zlabinger, P. Steinberger;
Vienna, Austria
205
Posters - August 26
155
P3.06.10 - Endothelial-lymphocyte interaction causes proliferation and transient Foxp3 enrichment of CD4+ T lymphocytes
Wen Chean Lim, E. Healy, T.M. Millar;
Southampton, United Kingdom
156
P3.06.11 - Setting an intrinsic brake on T cell division number: Roles for TCR affinity and IL-2 concentration
Julia M. Marchingo, S. Heinzel, C.J. Wellard, M.R. Dowling, P.D. Hodgkin;
Melbourne, Australia
157
P3.06.12 - Role of metalloprotease ADAM17 in regulating ICOSL-mediated humoral immune response
Joanna Marczynska, A. Ozga, A. Włodarczyk, D. Michalczyk, M. Bana , M. Kwitniewski, A. Hutloff, J. Scheller, S. Rose-John, J. Cichy;
Kraków, Poland
158
P3.06.13 - IL-35 is induced in human T cells upon co-stimulation via CD43 and PD-1
Madhura Modak, M. Seyerl, R. Aigner, O. Majdic, D. Olive, G. Zlabinger, J. Stöckl;
Vienna, Austria
159
P3.06.14 - High throughput generation of antibody secreting B-cell clones from peripheral blood of rabbits
Sonja Offner, F. Ros, I. Thorey, G. Tiefenthaler, K. Kaluza, V. Lifke, J.A.A. Fischer, S. Klostermann, J. Endl, E. Kopetzki, A. Pashine, B.
Kaluza, J. Platzer, S. Seeber;
Penzberg, Germany
160
P3.06.15 - Co-stimulatory effects of PD-1 in sublingual mucosa-mediated CD4+ T cell responses
Tatsukuni Ohno, C. Zhang, H. Yagita, M. Azuma;
Tokyo, Japan
161
P3.06.16 - Combining molecular adjuvant or a sub-immunizing dose of inactivated Foot and Mouth Disease Virus (FMDV)
with plasmids encoding P12A3C or VP1 protein enhances DNA vaccine potency
Erica Pereyra, V. Gnazzo, I. Soria, C. Langellotti, C. Bellusci, A. D´Antuono, M. Nora, V. Quattrocchi, P. Zamorano, C. Mongini;
Buenos Aires, Argentina
162
P3.06.17 - The impact of CD27 signaling on Wnt-mediated T cell expansion
Carla Ruckstuhl, C. Schürch, C. Riether, A. Ochsenbein;
Bern, Switzerland
163
P3.06.18 - Constitutively active STAT3 acts as a tolerogenic factor in human CD4+ T-cells
Klaus G. Schmetterer, A. Neunkirchner, D. Wojta-Stremayr, J. Leitner, P. Steinberger, W.F. Pickl;
Vienna, Austria
164
P3.06.19 - Adapters TRIM and LAX regulate transport and surface expression of CTLA-4 via Rab8 vesicles
Helga Schneider, M.C. Banton, K.L. Inder, E. Valk, C.E. Rudd;
Cambridge, United Kingdom
165
P3.06.20 - Signaling through Flt3 on activated splenic B-cells drives plasma cell differentiation
Mattias N.D. Svensson, K. Månsson, K.M.E. Andersson, M. Bemark, M. Brisslert, M. Bokarewa;
Gothenburg, Sweden
166
P3.06.21 - PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model
Horng-Tay Tzeng, P. Chen, P. Hsu;
Taipei, Taiwan
167
P3.06.22 - Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells
Ei Wakamatsu, R. Abe, D. Mathis, C. Benoist;
Noda, Japan
168
P3.06.23 - The immunomodulatory potency of interleukin 2 applied as ‘natural adjuvant’ bound to virus-like nanoparticles
is critically influenced by its membrane-anchor characteristics
Daniela Wojta-Stremayr, A. Neunkirchner, K.G. Schmetterer, W.F. Pickl;
Vienna, Austria
P4.06 IMMUNITY TO FUNGAL INFECTION
Session Time: Monday, August 26, 13:20 - 15:00
169
P4.06.01 - Anti-aspergillus fumigatus IgY antibodies and their protective efficacy in immunocompromised BALB/c mice
K. Kissoyan, N. Al-Akl, Alexander Abdelnoor;
Beirut, Lebanon
170
P4.06.02 - HeNe laser increases the pro-inflammatory cytokines production and the in vitro phagocytosis of P. brasiliensis
by macrophages
Thiago Alves da Costa, R. Thomé, R. Di Gangi, C. Francelin, L. Verinaud;
Campinas, Brazil
171
P4.06.03 - Cryptococcus gattii infection inhibits the induction of Th1 immune responses
Pornpimon Angkasekwinai, M. Chayakulkeeree;
Pathumthani, Thailand
172
P4.06.04 - Disentangling immunity and tolerance in candidiasis
Antonella De Luca, A. Carvalho, C. Cunha, G. Giovannini, L. Bartolommei, S. Moretti, C. Massi-Benedetti, M. Puccetti, R.G. Iannitti,
L. Romani;
Perugia, Italy
173
P4.06.05 - Paracoccidioides brasiliensis induces neutrophil extracellular traps in vitro
Tatiana F. Bachiega, R.K. Fernandes, D.R. Rodrigues, H.A. Balderramas, L.A. Dias-Melicio, Â.M.V.C. Soares;
Botucatu, Brazil
206
Posters - August 26
174
P4.06.06 - Characterization of Regulatory T Cells in Pulmonary Paracoccidioidomycosis Using Foxp3-GFP Transgenic Mice
Silvia Boschi Bazan, T. Costa, V. Calich;
São Paulo, Brazil
175
P4.06.07 - Deciphering the class and specificity of the T cell response to C. albicans
Simone Becattini, F. Mele, G. Gyuelveszi, L. Perez, A. Sette, A. Lanzavecchia, F. Sallusto;
Bellinzona, Switzerland
176
P4.06.08 - Variability in autologous/heterologous binder serum activity anti-Candida albicans and relationship with oral
presence of the yeast, in patients with risk factors
Daniela Brito, N. Semprún- Hernández1, J. Puentes, S. Azuero;
maracaibo, Venezuela, Bolivarian Republic of
177
P4.06.09 - Granulomas developed in paracoccidioidomycosis in oral lesions of patients and in experimentally infected mice
present similar patterns
Eva Burger, M. Miyazawa, D.T. Oliveira, A.A.C. Pereira, M.L. deCarli, I. Felipe, J.A.C. Hanemann;
Alfenas, Brazil
178
P4.06.10 - Cutaneous candidiasis in BALB/c mice
Tacito G. Campois, A.Z. Zucoloto, G.F.S. Quirino, L.A. Custodio, I.C. Costa, E.E.J. Araújo, T.I.E. Svidzinski, I. Felipe;
Londrina, Brazil
179
P4.06.11 - Immune response investigation in a murine model of sporotrichosis
L. Souza Ferreira, L. Carolina de Abreu Ribeiro, D. Cardoso Geraldo Maia, T. de Cássia Negrini, P. Alegranci, D. Cordeiro de Matos,
M. Bassi Quiles, M. Campos Polesi Placeres, Iracilda Zeppone Carlos;
Araraquara, Brazil
180
P4.06.12 - Identification of NETs (neutrophil extracellular traps) in tegumentary lesions of patients with paracoccidioidomycosis
Amanda M.D. Coletta, T.F. Bachiega, J.C.Q. Silva, B.R.S. Silva, S.A. Marques, M.E.A. Marques, J. Defaveri, A.M.V.C. Soares,
L.A. Dias-Melicio;
Botucatu, Brazil
181
P4.06.13 - High-throughput miRNA sequencing of human monocyte-derived dendritic cells confronted
with Aspergillus fumigatus
Kristin Czakai, I. Leonhardt, M. Walter, M. Bonin, O. Kurzai, H. Einsele, J. Loeffler;
Wuerzburg, Germany
182
P4.06.14 - Involvment of Notch-TLR signaling in experimental paracoccidioidomycosis
Lavínia M. Dal’Mas Romera, S.R. de Almeida;
São Paulo, Brazil
183
P4.06.15 - Thymic alterations during Paracoccidioides brasiliensis infection
Rosaria Di Gangi, T. Alves da Costa, C. Francelin, R. Thomé, L. Verinaud;
Campinas, Brazil
184
P4.06.16 - Anti-DEC-205 receptor carrying P10 induces protective response in experimental Paracoccidioidomycosis
Suelen S. Dos Santos, E. Rampazzo, K.S. Ferreira, C.P. Taborda, S.B. Boscardin, S.R. Almeida;
Sao Paulo, Brazil
185
P4.06.17 - Concanavalin-A induces IL-17 production during the course of Candida albicans infection
Ionice Felipe, P.G.C. de Carvalho, L.A. Custodio, I. Conchon-Costa, C.G.T.J. Andrade, G.F.S. Quirino, E. Burger, R.S. Almeida;
Londrina, Brazil
186
P4.06.18 - Inhibition of PGE2 and LTB4 production by dendritic cells induced by Paracoccidioides brasiliensis is associated
with the non maturation of these cells
Reginaldo K. Fernandes, T.F. Bachiega, D.R. Rodrigues, M.A. Golim, L.A. Dias-Melicio, H.A. Balderramas, R. Kaneno, Â.M.V.C. Soares;
Botucatu, Brazil
187
P4.06.19 - Therapy with scFv transfected-dendritic cells induce a decrease levels of specific IgG2b upon Paracoccidioides
brasiliesnsis infection
G.P.J. Jannuzzi, J.R.F.A. Almeida, S.R.A. Almeida, Karen S.F. Ferreira;
Diadema, Brazil
188
P4.06.20 - In pulmonary paracoccidioidomycosis, IDO exerts a protective effect to susceptible mice but a deleterious effect
to resistant mice
Eliseu Frank de Araujo, V.L.G. Calich;
São Paulo, Brazil
189
P4.06.21 - Evaluation of infiltration with important acquired immune cells in kidney and spleen of mouse model in groups
affected by systemic candidiasis, treated by etanolic extract of Zataria multiflora Boiss. in comparison to control groups
Hadi Ghazanfari, N. Hassannejad, M. Bayat, P. Dehghan, S. Hejazi, S. Ghanadian;
Isfahan, Iran, Islamic Republic of
190
P4.06.23 - Differential immune reactivity of Paracoccidioides brasiliensis phylogenetic species S1, PS2 and P. lutzii antigens
by paracoccidioidomycosis patients` sera
Eiko N. Itano, A. Lenhard-Vidal, J.P. Assolini, A. Sano, C.S.O. Bredt, M.A. Ono;
Londrina, PR, Brazil
191
P4.06.25 - Protein-based Mycosis Vaccines: Mechanism and Prospects for Future Human Use
Markus Kalkum, D. Diaz-Arevalo, J. Champer, T.B. Hong, K. Vega, J.I. Ito;
Duarte, United States
192
P4.06.26 - Preliminary evaluation of antigens from Paracoccidioides brasiliensis responsible for protective immune
response induced in P. brasiliensis-infected mice by treatment with complete Freund’s adjuvant
Taise N. Landgraf, F.F. Fernandes, G. Peron, A.A.M. Coelho-Castelo, A. Panunto-Castelo;
Ribeirão Preto, Brazil
207
Posters - August 26
193
P4.06.27 - CD5 modulates the inflammatory response to fungal cell wall components
Marc Orta, E. Carreras, R. Fenutría, I. Simões, C. Raman, F. Lozano;
Barcelona, Spain
194
P4.06.28 - Host parasite interaction in Drosophila melanogaster
Francesco Paparazzo, S. Hutter, A. Tellier, W. Stephan;
Martinsried, Germany
195
P4.06.29 - Inhibition of neutrophil extracellular traps (NETs) by Cryptococcus neoformans: involvement of the capsular
polysaccharide Glucuronoxylomannan (GXM)
Juliana D.B. Rocha, M.M.T.C. Nascimento, M.P. Nunes, D. Decote-Ricardo, G.A. DosReis, E.M. Saraiva, C.G. Freire-de-Lima;
Rio de Janeiro, Brazil
196
P4.06.30 - The resistance to infection by Paracoccidioides brasiliensis requires production of IL-6, IL-17 and IL-23
Fernanda A. Rocha, N. Ketelut-Carneiro, J.S. Silva;
Ribeirão Preto, Brazil
197
P4.06.31 - In situ expression of regulatory cytokines in oral paracoccidioidomycosis lesions
Denise B.R. Rodrigues, M.S. Araujo, P.M. Alves, S.A.L. Pereira, L.M.B. Lima, M.F. Silva, V. Rodrigues;
Uberaba, Brazil
198
P4.06.32 - Interferon-gamma production by human neutrophils upon challenge with Paracoccidioides brasiliensis
Daniela R. Rodrigues, R.K. Fernandes, H.A. Balderramas, T.F. Bachiega, S.A. Calvi, L.A. Dias-Melicio, M. Penitenti, M.R.V. Ikoma,
A.M.V.C. Soares;
Botucatu, Brazil
199
P4.06.33 - Interaction between monocyte-derived dendritic cells from active and cured paracoccidioidomycosis patients
and Paracoccidioides brasiliensis antigens: differences on phenotype, cytokines release and lymphoproliferation
Paula K. Sato, T.M. Oshiro, É.C. Passos, C.L. Diogo, C.A. Fonseca, M.A. Shikanai-Yasuda;
São Paulo, Brazil
200
P4.06.34 - Frequencies of Heterologous Serum Agglutination (FHSA) Heterologous Representativeness Index (HRI)
and Autologous Reactivity as indicators of variability in binder activity anti-Candida albicans - Evaluation in age groups
of healthy individuals carriers of the yeast in oral cavity
Neomar Semprún Hernández, A. Bohórquez Visier, M. Ribas, R. Colmenares, S. Azuero;
Cabimas, Venezuela, Bolivarian Republic of
201
P4.06.35 - IL-18 does not modulate dectin-1 expression on human monocytes challenged with Paracoccidioides brasiliensis
M.B. Cestari, T.F. Bachiega, R.K. Fernades, Juliana C.Q. Silva, M.A. Golim, A.M.V.C. Soares, L.A. Dias-Melicio;
Botucatu, Brazil
202
P4.06.36 - Dectin-1 plays a prominent role in the immune response against the dermatophyte “Trichophyton rubrum” in
murine model
Fábio S.Y. Yoshikawa, S.R. de Almeida;
São Paulo, Brazil
203
P4.06.37 - The role of IL-6 and IL-8 in vulvovaginal candidiasis in adolescent Girls
Uktam K. Ziyadullaev;
Tashkent, Uzbekistan
P4.07 IMMUNITY TO HELMINTH INFECTION
Session Time: Monday, August 26, 13:20 - 15:00
204
P4.07.01 - Involvement of Treg and alternatively activated macrophages in evasion strategies during hydatidosis
Manel Amri, C. Touil-Boukoffa;
Algiers, Algeria
205
P4.07.02 - Galectin-like molecule in parasite inhibits remission of experimental autoimmune encephalomyelitis
by enhancing auto-reactive B cells
So Jin Bing, D. Ha, S. Lee, J. Cho, S. Park, H. Yu, Y. Jee*;
Jeju, Korea, Republic of
206
P4.07.03 - Anisakis simplex allergens remain biologically active after canning and simulated gastric fluid treatment
of parasitized fish
Noelia Carballeda-Sangiao, A. Rodríguez-Mahíllo, F. Olivares Ponce, M. Tejada, M. Careche, I. Moneo, M. Gonzalez-Muñoz;
Madrid, Spain
207
P4.07.04 - Immunomodulatory effect of Toll-like receptor 7/8-agonist (imidazoquinoline Resiquimod) in experimental
secondary hydatidosis infection
Margherita Conchedda, V. Seu, A. Caddori, A. Caredda, F. Gabriele;
Monserrato (Cagliari), Italy
208
P4.07.05 - Immunomodulation by TLR-7-agonist, IL-27 or IL-25 in Hymenolepis diminuta infection in rats
Margherita Conchedda, V. Seu, S. Capra, A. Caredda, F. Gabriele;
Monserrato (Cagliari), Italy
209
P4.07.06 - An essential role of galectin-1 in driving Th2-polarized responses during helminth infection
Sebastian Dergan Dylon, J. Ilarregui, L. Rutitzky, M. Stadecker, G. Rabinovich;
Buenos Aires, Argentina
210
P4.07.07 - The change of CD4+CD25+ regulatory T cells and related cytokines in mice infected
with Echinococcus multilocular
Jian-Bing Ding, X. Ma, H. Zhao, Y. Zhu, F. Zhang, H. Wen;
Urumqi,Xinjiang, China
208
Posters - August 26
211
P4.07.08 - Heligmosomoides polygyrus L4 stage from inflammatory milieu effects on dendritic precursor JAWSII cells
K. Donskow-Lysoniewska, K. Brodaczewska, Maria Doligalska;
Warsaw, Poland
212
P4.07.09 - Chitosan stimulates lymphocyte proliferation during muscle phase of Trichinella spiralis infection in mice
K. Brodaczewska, N. Wolaniuk, K. Donskow-Lysoniewska, Maria Doligalska;
Warsaw, Poland
213
P4.07.10 - The role of TLR3 in the development of a protective immune response against Plasmodium
Marion Draheim, J. Roland, S. Pied;
Lille, France
214
P4.07.11 - Oral Fluids: utility in parasitic infections diagnosis
Yousr Galaï, M. Benabid, F. Amri, K. Aoun, A. Bouratbine;
Belvedere Tunis, Tunisia
215
P4.07.12 - Schistosomiasis vaccine discovery using high throughput schistosome tegument proteins microarray recognition
Soraya T. Gaze Jangola, P. Driguez, J. Bethony, D. MacManus, D. Doolan, R. Correa-Oliveira, P. Felgner, A. Loukas;
Belo Horizonte, Brazil
216
P4.07.14 - Differential expression of ovine TLR2 and TLR4 in peripheral blood mononuclear cells cultured
with hydatid cyst derived antigens
Alireza Haghparast, N. Soleymani, H. Borji, A. Naghibi, F. Taran, J. Mehrzad, M. Nazem Shirazi, M. Torabi;
Mashhad, Iran, Islamic Republic of
217
P4.07.15 - Induction of regulatory T cells by Opisthorchis viverrini
Chamraj Kaewraemruaen, R.W. Sermswan, S. Wongratanacheewin;
Khon Kaen, Thailand
218
P4.07.16 - Down regulation of NKG2D and Fc gamma receptor I in peripheral blood mononuclear cells induced
by excretory-secretory antigens from the third stage Gnathostoma spinigerum larvae (L3)
Yaowapa Maneerat, S. Benjathammaraksa, Y. Eshita, R. Kumsiri, K. Wetchabut, S. Nuamtanong, T. Kalambaheti, J. Waikagul;
BKK, Thailand
219
P4.07.17 - Swiprosin-1/EFhd2 limits autoantibody and IgE levels by restricting co-stimulation dependent B cell activation
S. Brachs, A. Turqueti-Neves, C. Lang, B. Brachvogel, M. Bösl, T. Winkler, D. Voehringer, H. Jäck, Dirk Mielenz;
Erlangen, Germany
220
P4.07.18 - Regulation of intestinal immune response by selective removal of the anterior, posterior, or entire pituitary
gland in Trichinella spiralis infected golden hamsters
R. Hernández-Cervantes, A. Quintanar-Stephano, V. López-Salazar, L. López-Griego, R. Hernández-Bello, J.C. Carrero,
K.E. Nava-Castro, Jorge Morales-Montor;
México, D.F., Mexico
221
P4.07.19 - The effects of astaxanthin in improving age associated declines of Th2 immune responses
Motoko Morimoto, S. Abe, N. Azuma, S. Kamei, K. Dewa;
Sendai City, Miyagi, Japan
222
P4.07.20 - Dendritic cell capture and transfer of HIV-1 to CD4+ T lymphocytes is inhibited by helminth parasite antigens
Emily E.I.M. Mouser, H.H. Smits, M. Yazdanbakhsh, E.C. de Jong, G. Pollakis, W.A. Paxton;
Amsterdam, Netherlands
223
P4.07.21 - Helminth infection alters mood and short-term memory as well as neurotransmitter and cytokine levels in the
mouse hippocampus
Karen E. Nava-Castro, J. Morales-Montor, O. Picazo, H. Besedovsky, R. Hernández-Bello, L. López-Griego, E. Becerril, J. Moreno,
L. Pavón, I. Camacho-Arroyo;
México, D.F., Mexico
224
P4.07.22 - CD28 is required for protection against Nippostrongylus brasiliensis secondary infection and recall of memory
responses in inducible CD28 deleting mice
Hlumani H. Ndlovu, M. Darby, M. Froelich, W. Horsnell, F. Ludher, T. Hunig, F. Brombacher;
Cape Town, South Africa
225
P4.07.23 - Analysis of Schistosoma mansoni candidate antigens as diagnostic targets for schistosomiasis
P. O. Ogongo, A.R. Wilson, Thomas M. Kariuki;
Nairobi, Kenya
226
P4.07.24 - Leukocyte adhesion to mesenteric endothelial cells mediated by P2Y1 receptor activation during schistosomiasis
Suellen D.S. Oliveira, N.F. Oliveira, R. Coutinho-Silva, C.L.M. Silva;
Rio de Janeiro, Brazil
227
P4.07.25 - Purinergic signaling in mesenteric endothelial cells and peritoneal macrophages in chronic inflammation
Suellen D.S. Oliveira, N.F. Oliveira, J.R. Meyer-Fernandes, C.L.M. Silva, R. Coutinho-Silva;
Rio de Janeiro, Brazil
228
P4.07.26 - Atopic responses among pre-school children in a schistosomiasis endermic community in Zimbabwe
Noah H. Paul, N. Rujeni, F. Chidzwondo, N. Midzi, F. Mutapi, T. Mduluza, T. Mduluza, T. Mduluza, T. Mduluza, T. Mduluza, T. Mduluza;
Harare, Zimbabwe
229
P4.07.27 - Impaired CXCR4/CXCL12 chemokine receptor/ligand axis limits filarial infection
Nicolas Pionnier, E. Brotin, G. Karadjian, N. Vallarino-Lhermitte, A. Nieguitsila, P. Hémon, M. Aknin, F. Bachelerie, C. Martin;
Paris, France
230
P4.07.28 - Opisthorchis viverrini induces Th17 cytokine responses in hamsters
Supavadee Polyiam, Y. Huang, R. Anderson, S. Wongratanacheewin, R.W. Sermswan;
Khon Kaen, Thailand
209
Posters - August 26
231
P4.07.29 - Study of nitric oxide metabolites(NOx) production during human hydatidosis: Relationship with cyst fertility
Zeghir-Bouteldja Razika, T. Chafia;
Algeria, Algeria
232
P4.07.30 - Evaluation of CCA urine test for diagnosis of Schistosoma mansoni infection in Brazil
Alda M.S. Silveira, C. Caffrey, M.H. Hsieh, D. Ray, B. Suzuki, L.A.O. Fraga;
Governador Valadares, Minas Gerais, Brazil
233
P4.07.31 - High IL-4 production related to granuloma development in high-tolerogenic mice infected with Schistosoma mansoni
Daniel A. Tavares, A.C. da Silva, A.M.L. Xavier;
Rio de Janeiro, Brazil
234
P4.07.32 - Reduction of B lymphocytes production in mice genetically selected for humoral response and infected with
Schistosoma mansoni
Aurelizia M.L. Xavier, M.F.S. da Silva, E. Hayashi, A.C. da Silva, D.A.G. Tavares;
Niteroi, Brazil
235
P4.07.33 - Ultrastructural alterations in adult Schistosoma mansoni harbored in low-inflammatory mice
Aurelizia M.L. Xavier, M.F.S. da Silva, E.V. Guimarães, A.C. da Silva, A.H.A. Moraes Neto, D.A.G. Tavares;
Niteroi, Brazil
236
P4.07.34 - Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in Strongyloides
venezuelensis-infected mice
Koubun Yasuda, T. Muto, M. Matsumoto, Y. Sasaki, K. Matsushita, T. Yoshimoto, K. Nakanishi;
Nishinomiya, Japan
P4.08 IMMUNITY TO PROTOZOAN PARASITE INFECTION
Session Time: Monday, August 26, 13:20 - 15:00
237
P4.08.01 - CCL3, CCL4 and CXCL8 chemokines mRNA expression in human neutrophils in response to Leishmania infantum
A. Hematzadeh, S. Pakzad, T. Naji, Soheila Ajdary;
Tehran, Iran, Islamic Republic of
238
P4.08.02 - Trypanosoma cruzi oral/intragastric infection in murine model: infection and immune response features of the host
Juliana B. Albuquerque, D.S. Santos, L.R. Berbert, C.E. Carvalho-Pinto, A.R. Pérez, O. Botasso, E. Roggero, R. Manarin, W. Savino,
J. de Meis;
Rio de Janeiro, Brazil
239
P4.08.03 - Congenital infection with Trypanosoma cruzi primes cord blood Vδ2 T cells to proliferate in response
to isopentenyl pyrophosphate
Cristina Alonso-Vega;
Cochabamba, Bolivia, Plurinational State of
240
P4.08.04 - Phenotypic and functional analysis of CD4+FoxP3+ regulatory T cells (TREG) in the early phase
of murine infection with Trypanosoma cruzi
B. Villas-Bôas, R.S. do Nascimento, M. D’Império-Lima, José M. Alvarez;
São Paulo, Brazil
241
P4.08.05 - Phagocyte-derived from cells B1 (B1CDP) facilitate Leishmania major infection in vitro via IL-10 and PGE-2 secretion
Angélica F. Arcanjo, I.F. La Roque de Freitas, J.D.B. Rocha, M.P. Nunes, A. Popi, M. Mariano, C. Bandeira-de-Melo, G.A. DosReis,
D. Decote-Ricardo, C.G. Freire-de-Lima;
Rio de Janeiro, Brazil
242
P4.08.06 - Analysis of Metalloproteinases and their Inhbitors in Chronic Chagas’Cardiomyopathy
Monique A. Baron, P.C. Teixeira, R.H. Santos, E.C. Mairena, I.C. Navarro, N.A. Stolf, A. Fiorelli, J. Kalil, L.R.P. Ferreira, E.C. Neto;
São Paulo, Brazil
243
P4.08.07 - Role of IL-9 in the intestinal inflammation induced after Toxoplasma gondii infection
Luciana Benevides, M.S. Dias, M. Souza, D.M. Fonseca, J.S. Silva;
Ribeirão Preto, Brazil
244
P4.08.08 - Splenic phagocytes shape the immunity to Plasmodium infection in distinct but complementary ways
Henrique Borges Da Silva, P.J. Spence, S. Reece, J. Thompson, N. Van Rooijen, J. Langhorne, C. Tadokoro, M.R. D’Império Lima;
São Paulo, Brazil
245
P4.08.09 - Neutrophil migration during placental malaria
Stéphanie Boström, A. van der Does, B. Amulic, M. Troye-Blomberg;
Stockholm, Sweden
246
P4.08.10 - Histopathological study in intestinal wall of dogs naturally infected with Leishmania in the intestines
Wilma A. Buzetti, D.T. Silva, M.F. Neves, A.G.S. Lins;
Ilha Solteira, Brazil
247
P4.08.11 - Comparative evaluation of rK39 and soluble antigen ELISA, IFAT and parasitological tests for Canine Visceral
Leishmaniasis diagnosis
D.T. Silva, Wilma A.S. Buzetti, M.F. Alves, M.S. Paixão, M.S. Tenorio;
Ilha Solteira, Brazil
248
P4.08.12 - Role of L-arginine during acute phase of Chagas disease in pregnant Wistar rats infected with the Y strain
of Trypanosoma cruzi
Ana A. Carraro Abrahão, C.M. Bronzon da Costa, M.R. Barbosa de Freitas, V. Brazão, C.D. dos Santos, C.C. Kuehn, M.A. Sala,
J.C. do Prado Júnior;
Ribeirão Preto, Brazil
210
Posters - August 26
249
P4.08.13 - Zinc intake improves immune response during pregnancy in wistar rats infected with Y strain of Trypanosoma cruzi
Ana A. Carraro Abrahão, C.M. Bronzon da Costa, M.R. Barbosa Freitas, V. Brazão, C.D. Santos, M.A. Sala, J.C. Prado Júnior;
Ribeirão Preto, Brazil
250
P4.08.14 - T cell immunoglobulin- and mucin-domain-containing molecule-3 secretion by patients with active cutaneous
leishmaniasis
Lucio R. Castellano, D. Correia, M.V. Silva, H. Dessein, A. Dessein, V. Rodrigues;
João Pessoa, PB, Brazil
251
P4.08.15 - Trypanosomiasis-associated modulation of B cell lymphopoiesis and immune function
Jennifer Cnops, V. Bockstal, F. Kauffmann, P. Garside, M. Radwanska, C. De Trez, S. Magez;
Brussels, Belgium
252
P4.08.16 - Towards an immunosense vaccine to prevent toxoplasmosis
Hua Cong, Q. Yuan;
Jinan, China
253
P4.08.17 - Effect of congenital toxoplasmosis on the uNKs cells population and their products in a mouse model
Dolores Correa, A. Besné-Mérida, C. Cedillo-Peláez, C. Rico-Torres, F. García-Vázquez, J. Farfán-Morales, J. Vargas-Villavicencio;
Mexico, Mexico
254
P4.08.18 - Metalloproteinases 2 and 9 are differentially expressed in patients with indeterminate and cardiac clinical
forms of Chagas disease
Rodrigo Correa-Oliveira, J.A.S. Gomes, L.R. Garzoni, M.M. Saraiva, R.M. Saraiva, R.M. Saraiva, L.C. Sangenis, M.C. Chambela,
F.F. Araujo, A. Teixeira-Carvalho, M.P. Damasio, V.A. Valente, K.S. Ferreira, G.R. Souza, M.O.C. Rocha;
Belo Horizonte, Brazil
255
P4.08.19 - Kinetics of the IgG antibodies acquisition in Plasmodium vivax infected individuals living
in a low malaria transmission area in Brazil
Maristela G. Cunha, M.M. Póvoa, E.S. Silva, A.M. Ventura, M.D. Ohnishi, N. Sepulveda, P.H. Corran, E. Riley, C. Drakeley;
Belém, Brazil
256
P4.08.20 - Molecular basis of CD8+T cell’s protective response to Toxoplasma infection
W. Gao, H. Chu, E. Robey, Shaodong Dai;
Denver, United States
257
P4.08.21 - NOD2-dependent Th1 response impairs host survival during N. caninum infection
Marcela Davoli Ferreira, C. Martins Mota, D. Morais da Fonseca, D. Lima Junior, J. Santana da Silva, T. Mineo;
Ribeirão Preto, Brazil
258
P4.08.22 - Glucocorticoid mediated caspase-8 and caspase-9 activation promotes thymocyte apoptosis
and thymus atrophy in Trypanosoma cruzi infection
D.A. Farias-de-Oliveira, D.M.S. Villa-Verde, P.H.N. Panzenhagen, D.S. dos Santos, L.R. Berbert, W. Savino, Juliana de Meis;
Rio de Janeiro, Brazil
259
P4.08.23 - Melatonin and lycopene role on immune system against Chagas’disease
José Clóvis do Prado Júnior, M.D. Filipin, V. . Brazão, M.A. Toldo, F.H. Santello;
Ribeirão Preto, Brazil
260
P4.08.24 - Impact of the absence of galectin-3 on the course of experimental Trypanosoma cruzi infection
Danielle S. dos Santos, J.B. de Albuquerque, L.R. Berbert, D.A. Farias-de-Oliveira, L.V.C. Guillermo, W. Savino, J. de Meis,
D.M.S. Villa-Verde;
Rio de Janeiro, Brazil
261
P4.08.25 - Casein diets prevent experimental cerebral malaria by enhancing host pro-inflammatory immune responses
during early stage
Yonghui Feng, X. Sun, X. Wei, J. Liu, Y. Cao;
Shenyang, China
262
P4.08.26 - Association of IL-1β in the severity of diffuse cutaneous leishmaniasis
Edith Fernández, C. Rangel, K. Carrillo, N. Salaiza, I. Becker;
Mexico, Mexico
263
P4.08.27 - Oxidized ATP action on macrophage during infection with Leishmania amazonensis
Vanessa R. Figliuolo da Paz, S.P. Chaves, G.F. Santoro, C.M.L.M. Coutinho, J.R. Meyer-Fernandes, B. Rossi-Bergmann,
R. Coutinho-Silva;
Rio de Janeiro, Brazil
264
P4.08.28 - Purinergic receptor functionality controls murine infection by L. amazonensis
Vanessa R. Figliuolo da Paz, S.P. Chaves, L.E. Savio, É. Salles, H. Guedes, M.R. D’Império, B. Rossi-Bergmann, R. Coutinho-Silva;
Rio de Janeiro, Brazil
265
P4.08.29 - A non-regulated Th1/Th2 inflammatory immune response is linked to clinical problems in congenital toxoplasmosis
Yevel Flores-García, R. Figueroa-Damián, I. Cañedo-Solares, D. Correa;
Mexico City, Mexico
266
P4.08.30 - Sero-immunoproteomics of Leishmania infantum: a reappraisal of the role of antibodies in protection
to the development of kala-azar and antigen discovery for the design of bio-markers and vaccines
Luiz G.A. Gardinassi, G.R. Garcia, S.R. Maruyama, F.O. Silva, C.H.N. Costa, R.P. Almeida, A.M.R. Jesus, I.K.F.M. Santos;
Ribeirao Preto, Brazil
267
P4.08.31 - Myeloid-derived suppressor cells are key players to balance the exacerbated inflammatory response during
acute Trypanosoma cruzi infection
A. Arocena, L. Onofrio, A. Paroli, M. Aoki, Susana Gea;
Córdoba, Argentina
211
Posters - August 26
268
P4.08.32 - Evaluation of immunological responses against cocktail DNA vaccine of Leishmania major genes in BALB/c mice
Fatemeh Ghaffarifar, A. Dalimi, Z. Sharifi, Z.M. Hassan, O. Jorjani, F. Tabatabaie;
Tehran, Iran, Islamic Republic of
269
P4.08.33 - Role of arachidonic acid metabolites in Trypanosoma cruzi infection
N.A. Guerrero, M. Fresno, Núria Gironès;
Madrid, Spain
270
P4.08.34 - Role of B-1 cells in experimental Leshmania amazonensis infection
Wagner F.K.M. Gonzaga, M.M. Geraldo, B.C. Vivanco, J.D. Lopes, P. Xander;
São Paulo, Brazil
271
P4.08.35 - Identification of Toxoplasma gondii sequences of potential diagnostic value via cDNA library immunoscreening
Hossein Hajghani;
Kerman, Iran, Islamic Republic of
272
P4.08.36 - Effect of Phlebotomus papatasi saliva extracts on humoral and cellular immune response in individuals living in
an endemic area for leishmania major infection
Wafa Kammoun Rebai, I. Naouar, A. Toumi, A. Ben Salah, H. Louzir, A. Meddeb-Garnaoui;
Tunis, Tunisia
273
P4.08.37 - Cytokine responses & parasite genotypes associated with pathogenesis of human African trypanosomiasis
trypanosomiasis in North-eastern Uganda
Charles D. Kato, P. Alibu, E. Matovu;
Kampala, Uganda
274
P4.08.38 - Induction of protective immune responses against cutaneous leishmaniasis in BALB/c mice by a vaccine containing
a new low pathogenic strain of Leishmania major along with imiquimod
Vahid Khaze, M. Alimohammadian, S. Ajdary, B. Laamrad, F. Riazi-Rad, H. Darabi, F. Bahrami;
Tehran, Iran, Islamic Republic of
275
P4.08.39 - Antiparasitic effects of Foeniculum vulgare extracts against Toxoplasma gondii
Fariba Khoshzaban, F. Ghaffarifar;
Tehran, Iran, Islamic Republic of
276
P4.08.40 - Serum nitric oxide levels in subjects with high bilirubin value in comparison of normal healthy control subjects
Ramesh Kumar;
Jhansi, Uttar Pradesh, India
277
P4.08.41 - CD4-CD8- T cells, B cells and complement are critical for resolution of Babesia microti infection in the absence of CD4
Maude Leveque, Z. Silver, C. Wilson, J. Su, S. Telford, J.A. Gelfand, P.J. Krause, E. Vannier;
Boston, United States
278
P4.08.42 - Alteration of s-Fas and s-FasL ligand expression during canine visceral leishmaniasis
Valéria M. Lima, J. Perosso, S.d. Ferreira, K.L.O. Silva, L.M. Melo;
Araçatuba, Brazil
279
P4.08.43 - Phagocytosis of promastigotes of Leishmania amazonensis by B-1 cells
M.M. Geraldo, F.M.C. Barbosa, W.F.K.M. Gonzaga, B.C. Vivanco, P. Xander, P. Xander, José D. Lopes;
São Paulo, Brazil
280
P4.08.44 - A Mechanistic Insight Into Arabinosylated Lipoarabinomannan (Ara-LAM) Mediated Modulation
Of IFN-γ signaling and Different Transcription Factors During Experimental Visceral Leishmaniasis
Subrata Majumdar, S. Majumder, B. Paul Chowdhury;
Kolkata, India
281
P4.08.45 - Leishmania-induced biphasic ceramide generation in macrophages is crucial for uptake and survival of the parasite
Saikat Majumder, R. Dey, S. Bhattacharjee, A. Rub, G. Gupta, S. Bhattacharyya Majumdar, B. Saha, S. Majumdar;
Kolkata, India
282
P4.08.46 - Leishmania infantum excreted/secreted proteins impairs differentiation and modulates cytokine production
in human dendritic cells and monocytes
Wafa Markikou-Ouni, S. Drini, M. Chenik, A. Meddeb-Garnaoui;
Institut Pasteur de Tunis, Tunisia
283
P4.08.56 - Excreted/secreted proteins of Leishmania major induce production of IFN-g and granzyme B by CD4+T cells
I. Naouar, T. Boussoffara, M. Ben Ahmed, N. Belhaj Hmida, A. Ben Salah, H. Louzir, Wafa Kammoun;
Tunis Belvedere, Tunisia
284
P4.08.47 - Leishmania infantum excreted/secreted proteins impairs human dendritic cells differentiation and modulates
cytokines production by human dendritic cells and monocytes
W. Markikou-Ouni, S. Drini, M. Chenik, A. Meddeb-Garnaoui, Wafa Kammoun;
Institut Pasteur de Tunis, Tunisia
285
P4.08.48 - Role of neutrophils in parasite persistence and in host immunity during the initial phase of L. chagasi
experimental infection
Claudia Marques, S. Falcão, F. Novais, D.M. Santos, A. Rodrigues, F. Passero, D. Mateus, G.M. Santos-Gomes, A. Barral, C.I. de Oliveira;
Lisboa, Portugal
286
P4.08.49 - Salivary antigen SP32 is the immunodominant target of the antibody response to Phlebotomus papatasi bites in humans
Soumaya Marzouki;
Tunis, Tunisia
287
P4.08.50 - Role of P2X7 receptor in the response of phagocytes to Plasmodium chabaudi infection
Maria Menezes, É. Salles, A. Cassado, E. Amaral, H. Silva, J. Álvarez, R. Coutinho-Silva, M. D’Império Lima;
São Paulo, Brazil
212
Posters - August 26
288
P4.08.51 - Relationship between parasite load and renal lesion in acute experimental Chagas disease
Camila B. Miguel, W.F. Rodrigues, J.R.D. Lemos, R.C. Parreira, R.B. Miguel, A.P. Rogério, C.J.F. Oliveira, J.E. Lazo-Chica;
Uberaba, Brazil
289
P4.08.52 - Temporal transcriptomic dynamics of human macrophage response to Leishmania major infection
Ghada Mkannez, K. Ghedira, F. Guerfali, I. Rabhi, A. Daskalaki, B. Trentin, R. Sghaier, H. Attia, S. Sysco Consortium, O. Collaboraters;
Tunis, Tunisia
290
P4.08.53 - MAP kinases activation in macrophages during infection with Neospora caninum
Caroline M. Mota, A.M. Oliveira, M.D. Ferreira, F.M. Santiago, P.S.C. Barros, J. Mineo, T.W.P. Mineo;
Uberlândia, Brazil
291
P4.08.54 - Seroepidemiology of toxoplasmosis in childbearing women of eastern azarbaijan - iran
Mohammad Naghavi - Behzad, A. Naghavi-Behzad, R. Piri, N. Nezami;
Tabriz, Iran, Islamic Republic of
292
P4.08.55 - A successful safety trial of gentamicin-attenuated Leishmania infantum vaccine in an endemic area in Southeast
of Iran
Mohammad J. Namazi, H. Daneshvar, H. Kamyabi;
Sabzevar, Iran, Islamic Republic of
293
P4.08.57 - Polymorphisms of cytokines genes associated with ocular toxoplasmosis
Carlos Andrés Naranjo, J. Sepúlveda Arias, J. Gómez, A. De la Torre;
Pereira, Colombia
294
P4.08.58 - Immunomodulation of Leishmania infection by murine mesenchymal stromal cells in vitro
Ana P. Nazario, A.E. Vargas, A.P. Dagnino, P.S. Almeida, E. Engster, P.R.T. Romao;
Porto Alegre, Brazil
295
P4.08.59 - Effect of Entamoeba histolytica calreticulin in the immune response of patients with acute amoebic liver abscess
Miriam E. Nieves-Ramirez, E. Gonzalez, P. Moran, A. Valadez, M. Garcia, L. Rojas, O. Partida-Rodriguez, E. Hernandez, R. Cerritos,
C. Ximenez;
Mexico City, Mexico
296
P4.08.60 - Polymorphism of lcr1 gene in different Leishmania species
Hamid M. Niknam, F. Firoozeh Abrishami, K. Kiana Fatemi, H. Azimian;
Tehran, Iran, Islamic Republic of
297
P4.08.61 - Analysis of the cardiac disorder caused by the intracellular parasite Toxoplasma gondii
Kazumi Norose, T. Ishikawa, K.X. Li, T. Ogura, H. Nakaya, M. Furuya, M. Osawa;
Chiba, Japan
298
P4.08.62 - Adoptive transfer of Treg (CD4+Foxp3+) cells to B6 mice during Toxoplasma gondii infection induces
down-modulation of exacerbated inflammatory immune response but does not generate protection
Jonadab E. Olguín, J. Fernández, C. Castellanos, J. Campuzano, N. Salinas, R. Saavedra;
Ciudad de México, Mexico
299
P4.08.63 - Natural isotypic response against potential vaccine candidate Plasmodium falciparum Glutamate-Rich Protein
(GLURP) in individuals living in Brazilian malaria-endemic area
Lilian R. Pratt-Riccio, J.C. Lima-Junior, L.J.M. Carvalho, M. Theisen, F. Santos, J. Oliveira-Ferreira, C.T. Daniel-Ribeiro, D.M. Banic;
Rio de Janeiro, Brazil
300
P4.08.64 - Th2-skewed response depends on Insulin-like growth factor I in Leishmania (Leishmania) major-infection
Luiza C. Reis, E. Ramos-Sanchez, H. Goto;
São Paulo, Brazil
301
P4.08.65 - Modulation of T helper immune response by photodynamic therapy in experimental leishmaniasis
Virmondes Rodrigues, P.M. Alves, M.F. Silva, D.M. Souza, S.M.C.F. Carlos, M.V. Silva, T.P. Paulino, D.B.R. Rodrigues;
Uberaba, Brazil
302
P4.08.66 - Th17 and Tc17 cells on pregnant women seroposite and seronegative for toxoplasmosis
Virmondes J. Rodrigues, J.L.A. Silva, K.R. Oliveira;
Uberaba, Brazil
303
P4.08.67 - Inflammatory response of a prostate stromal cell induced by live Trichomonas vaginalis
Jae-Sook Ryu, S. Im, N. Gu, M. Ahn;
Seoul, Korea, Republic of
304
P4.08.68 - Do different T cell receptor sequences dictate the phenotype of memory CD8 T cells
in the Toxoplasma gondii-infected brain?
Anna Sanecka, E. Frickel;
London, United Kingdom
305
P4.08.69 - Chagas’disease: evaluation of melatonin and lycopene influence on cytokines’profile during acute phase
Fabricia H. Santello, M.D. Filipin, V. Brazão, M.A. Toldo, J. do Prado Júnior;
Ribeirão Preto, Brazil
306
P4.08.70 - Increased levels of interleukin-4 (IL-4), interleukin-10 (IL-10) and IFN-γ in Iranian Visceral Leishmaniasis (VL) Children
Narges Seyfizadeh, Z. Babaloo, M. Bonyadi, N. Seyfizadeh, N. Mirsamadi;
Tabriz, Iran, Islamic Republic of
307
P4.08.71 - Infection with Leishmania major induces a cellular stress response in tissue resident macrophages
Ana Caroline C. Silva, A.A. Filardy, C.M. Koeller, K.G. Pinto, M. Menezes Passos Diniz, F.L. Ribeiro-Gomes, M.F. Lopes,
C.G. Freire-de-Lima, M.P. Nunes, G.A. DosReis;
Rio de Janeiro, Brazil
213
Posters - August 26
308
P4.08.72 - Identification of proteins in Leishmania amazonensis extract that may enhance the parasite infection
Virgínia M.G. Silva, C.F. Araújo, C.M. Andrade, J.P.C. Cunha, F.K. Marchini, W.L.C. Santos, L.C.P. Carvalho;
Jequié, Brazil
309
P4.08.73 - Theileria parva: Genotypic and antigenic diversity in buffalo and buffalo associated- cattle
Tatjana Sitt, R. Pelle, L. Steinaa, W. Weir, I. Morrison, P. Toye;
Nairobi, Kenya
310
P4.08.74 - Plasma cytokine as biomarker of cardiac morbidity in Chagas disease
Giovane R. Sousa, J.A.S. Gomes, R.C.G. Fares, M.P.S. Damásio, A.T. Chaves, N.I. Medeiros, K.S. Ferreira, M.P. Nunes, R. Corrêa-Oliveira,
M.O.C. Rocha;
Belo Horizonte, Brazil
311
P4.08.75 - A new highly sensible method for division of patients with different forms of Chagas disease according
to cytokine production
Giovane R. Sousa, J.A.S. Gomes, R.C.G. Fares, M.P.S. Damásio, A.T. Chaves, K.S. Ferreira, N.I. Medeiros, M.P. Nunes, R. Corrêa-Oliveira,
M.O.C. Rocha;
Belo Horizonte, Brazil
312
P4.08.76 - High IL-17 expression is correlated with better cardiac function in human Chagas disease
M.O.C. Rocha, Giovane R. Sousa, R.C.G. Fares, M.P.S. Damásio, A.T. Chaves, K.S. Ferreira, V.A.A. Valente, M.P. Nunes, J.A.S. Gomes,
R. Corrêa-Oliveira;
Belo Horizonte, Brazil
313
P4.08.77 - The effects of recombinant protein based on Trypanosoma cruzi P21-His6 treatment in infected mice with
Leishmania amazonensis
C.M. Luise Junior, T.L. Teixeira, F.C. Machado, A.P.N. Quintal, Maria A. Souza, C.V. Silva;
Uberlandia, Brazil
314
P4.08.78 - Recombinant human thrombopoietin inhibits the development of murine experimental cerebral malaria
by decreasing the inflammatory response
Xiaodan Sun, Y. Pan, W. Xu, J. Liu, H. Shang, L. Cui, Y. Cao;
Shen Yang, China
315
P4.08.79 - Patients with visceral leishmaniasis present an increased expression of TLR2 and TLR4 in lymphocytes
and lipid and protein changes
M. Gatto, M.M. Abreu, M.A. Golin, J.C. Simão, Karen I. Tasca, L. Gollino, C.M.C.B. Fortaleza, P.C.M. Pereira, S.A. Calvi;
Botucatu, Brazil
316
P4.08.80 - Xanthine oxidase and inducible NOSynthase stress failed to efficiently suppress Leishmania major in BALB/c
bone marrow dendritic cells
Nabila Tounsi, S. Meghari, M. Moser, B. Djerdjouri;
Alger, Algeria
317
P4.08.81 - Leishmania-reactive CD3+CD4-CD8- (Double negative) T cells display functional characteristics of memory T cells
and protect against secondary challenge
Z. Mou, I. Okwor, D. Liu, Jude E. Uzonna;
Winnipeg, Canada
318
P4.08.82 - Molecular characterization T. gondii atypical strains isolated from pregnant women and their neonates
in Southern Brazil
Rogerio S. Vaz, V.T. Soccol;
Curitiba - Paraná, Brazil
319
P4.08.83 - Unusual T. gondii strains associated to congenital toxoplasmosis
Rogerio S. Vaz, V.T. Soccol;
Curitiba - Paraná, Brazil
320
P4.08.84 - Serological prevalence of Toxoplasma gondii antibodies in pregnant women from Southern Brazil
R.S. Vaz, Rogerio S. Vaz;
Curitiba - Paraná, Brazil
321
P4.08.85 - Congenital Toxoplasmosis: Current Brazilian public health policy
Rogerio S. Vaz;
Curitiba - Paraná, Brazil
322
P4.08.86 - Effect of Leishmania mexicana amastigotes in the regulation of L-arginine metabolism in classically
and alternatively activated macrophages
Arturo A. Wilkins-Rodríguez, A.R. Escalona-Montaño, M. Aguirre-García, L. Gutiérrez-Kobeh;
México, D.F., Mexico
323
P4.08.87 - B-1 cells increase susceptibility to murine viscetal leishmaniasis
Vanessa Xavier, B.C. Vivanco, W.F.K.M. Gonzaga, C.L. Barbieri, J.D. Lopes, P. Xander;
São Paulo, Brazil
P4.09 MALARIA PATHOGENESIS AND VACCINES
Session Time: Monday, August 26, 13:20 - 15:00
324
214
P4.09.02 - Targeting a Plasmodium vivax merozoite surface protein 1 fragment to the DEC205+ dendritic cell population
elicits strong antibody and T cell responses
Kelly N.S. Amorim, M.M. Yamamoto, S.B. Boscardin;
São Paulo, Brazil
Posters - August 26
325
P4.09.03 - T Regulatory cell function in Lethal Plasmodium berghei ANKA and Non-Lethal Plasmodium yoelii infection:
Role of Th17
Arindam Bhattacharyya;
Kolkata, India
326
P4.09.04 - Systems immunology approach to identify the molecular profile of T cells during Plasmodium mono
and mixed infections
Julie G. Burel, S.H. Apte, J.M. McCarthy, D.L. Doolan;
Brisbane, Australia
327
P4.09.05 - Immunogenicity and efficacy of Plasmodium falciparum MSP3-based immunogens in Saimiri sciureus monkeys
C. Bianco-Jr, P.H. Castro, C. Faro, F.A. Alves, P. Druilhe, C.T. Daniel-Ribeiro, Leonardo J.M. Carvalho;
Rio de Janeiro, Brazil
328
P4.09.06 - The response of P2X7 deficient and competent immune cells to Plasmodium chabaudi AS infection in chimeric mice
Alexandra A. Cassado;
São Paulo, Brazil
329
P4.09.07 - CD4+ T cell promote B cell polyclonal activation in an ICOS-dependent manner during Plasmodium chabaudi
infection
Sheyla I. Castillo-Méndez, S.M. Muxel, E.P. Amaral, C.A. Zago, É. Salles, L.R. Sardinha, N.O. Câmara, E. Faquim-Mauro, J.M. Álvarez,
M.R. D´Império Lima;
São Paulo, Brazil
330
P4.09.08 - Nitric oxide but not cytokine production by macrophages stimulated with malaria hemozoin is dependent on
Nod2 activation
Yolanda Corbett, N. Basilico, S. Parapini, S. D’Alessandro, D. Scaccabarozzi, B. Rocca, K. Fitzgerald, D. Golenbock, D. Taramelli;
Milan, Italy
331
P4.09.09 - High levels of heme correlate with severe malaria pathology and morbidity in patients from endemic areas in India
Esther Dalko, A. Panda, F. Herbert, R. Tripath, B. Ravindran, S. Sharma, B. Das, S. Pied;
Lille, France
332
P4.09.11 - Cellular cytokine and chemokine responses associated with susceptibility to severe malaria in children in Papua
New Guinea
D. Stanisic, J. Cutts, Emily Eriksson, F. Fowkes, J. Taraika, M. Laman, L. Manning, T. Davis, I. Mueller, L. Schofield;
Melbourne, Australia
333
P4.09.12 - Sexual hormones are involved in oxidative stress in mice infected with P. berghei ANKA
Martha Legorreta-Herrera, N.A. Mosqueda-Romo;
México, Mexico
334
P4.09.13 - Blood group O protects against complicated Plasmodium falciparum malaria by the mechanism of inducing
high levels of anti-malarial IgG antibodies
Amre Nasr, M. Eltoum, A. Yassin, G. ElGhazali;
Khartoum, Sudan
335
P4.09.14 - Targeting the Plasmodium chabaudi MSP1(19) protein to the DEC205 dendritic cell population induces faster
parasite clearence
Raquel H. Panatieri, H.B. da Silva, M.M. Yamamoto, M. D’Imperio Lima, S.B. Boscardin;
Sao Paulo, Brazil
336
P4.09.15 - Placental lesions as result of TLR4 activation by Plasmodium berghei are associated with low birth weight
Aramys S. Reis, R. Barboza, S.B. Boscardin, S. Epiphanio, C.R.F. Marinho;
São Paulo, Brazil
337
P4.09.16 - The P2X7 receptor contributes to protection and to ameliorate the clinical manifestations of blood-stage
Plasmodium chabaudi malaria
Érika M. Salles, M. Menezes, A. Cassado, E. Amaral, S. Castillo-Mendez, H. Silva, J. Alvarez, R. Coutinho-Silva, M. D’Império-Lima;
São Paulo, Brazil
338
P4.09.17 - Polygenic control of human antibody responses to synthetic malaria vaccine
Osvaldo A. Sant’Anna, M.V. Valero, A.G. Trezena, J. Kalil, M.E. Patarroyo;
São Paulo, Brazil
339
P4.09.18 - Inflammatory factors and leucocytes are involved in the pathogenesis of malaria associated acute lung
injury/acute respiratory distress syndrome in murine model
Michelle K. Sercundes, L.d. Ortolan, D. Debone, E.H. Aitken, M. Russo, J.M. Alvarez, C.R.F. Marinho, S. Epiphanio;
Sao Paulo, Brazil
340
P4.09.19 - Extracellular ATP accelerates malaria anemia
Kazutomo Suzue, M. Nishimori, M. Hirai, T. Imai, T. Taniguchi, H. Okada, C. Shimokawa, S. Koyasu, H. Hisaeda;
Maebashi, Gunma, Japan
341
P4.09.20 - The role of P2X7 receptor in hepatic necrosis caused by Plasmodium chabaudi AS infection
Flavia Sarmento Vieira, A. Freitas do Rosario, M. D’Imperio Lima;
Sao Paulo, Brazil
342
P4.09.21 - S-nitrosoglutathione prevents experimental cerebral malaria
Graziela M. Zanini, Y.C. Martins, P. Cabrales, J.A. Frangos, L.J.M. Carvalho;
Rio de Janeiro, Brazil
343
P4.09.22 - Pys48 and Pys25 DNA Vaccine supplement medicated the inhibitory development of Plasmodium yoelii
gametocytes into gametes
Li Zheng, Y. Cao;
Shenyang, China
215
Posters - August 26
P5.18 INFLAMMATORY BOWEL DISEASES
Session Time: Monday, August 26, 13:20 - 15:00
344
P5.18.01 - Modulation of macrophage differentiation by crotoxin from Crotalus durissus terrificus in acute intestinal
inflammation in mice
Caroline S. Almeida, J. Jacysyn, E.L. Faquim-Mauro;
São Paulo, Brazil
345
P5.18.02 - The role of IFITM genes in the pathogenesis of the gastro-intestinal tract
Zoya Alteber, E. Tzehoval, L. Eisenbach;
Rehovot, Israel
346
P5.18.03 - Profile of ANCA (Anti-Neutrophil Cytoplasmic Antibodies) and ASCA (Anti-Saccharomyces Cerevisiae mannan
Antibodies) in patients with IBD (Inflammatory Bowel Diseases): Crohn’s disease and Ulcerative Colitis
Siham Aziz, N. Tahiri Jouti, W. Badre, A. Naya, Z. Serhier, R. Alaoui, S. Zamiati;
Casablanca, Morocco
347
P5.18.04 - Glucocorticoid-induced leucine zipper (GILZ) regulates intestinal immune homeostasis and anti-inflammatory
effects of glucocorticoids
Oxana Bereshchenko, M. Coppo, M. Biagioli, T. Frammartino, M. Cimino, A. Venanzi, D. Sorcini, M. Di Sante, S. Bruscoli, C. Riccardi;
Perugia, Italy
348
P5.18.05 - Polymorphisms of NOD2/CARD15 and PTPN22 in Algerian adult inflammatory bowel disease (IBD)
Aziza Boukercha, A. Bouzidi, H. Saoula, F. Chemandji, M. Nakmouche, C. Touil-Boukoffa, H. Mesbah-Amroun;
Algiers, Algeria
349
P5.18.06 - Autoimmune diseases association study with the KIAA1109-IL2-IL21region in a Tunisian population
D. Bouzid, H. Fourati, A. Amouri, I. Marques, Olfa Abida, N. Tahri, C. Penha-Gonçalves, H. Masmoudi;
Sfax, Tunisia
350
P5.18.07 - Frequency of NOD2/CARD15 and MDR1 gene polymorphisms in a cohort of Algerian pediatric Crohn’s disease
patients
Amira Bouzidi, A. Boukercha, F. Benhassine, W. Messadi, C. Touil-Boukoffa, H. Mesbah-Amroun;
Algiers, Algeria
351
P5.18.08 - miR-132/212 cluster knockout ameliorated DSS-induced colitis
Ichino Chinen, T. Nakahama, N.T. Nguyen, D. Millrine, S. Lee, T. Kishimoto;
Suita, Japan
352
P5.18.09 - Overexpression of IL-9 and its receptor in Crohn’s disease
Mircea T. Chiriac, N. Nalleweg, G. Hundorfean, M.F. Neurath, J. Mudter;
Erlangen, Germany
353
P5.18.10 - Integrity of the splenic nerve is required to mediate the vagal anti-inflammatory effect on colonic inflammation
in a murine DSS-induced model of colitis
Léa M.M. Costes, B.J. Olivier, J. van der Vliet, W.J. de Jonge, G.E. Boeckxstaens, C. Cailotto;
Amsterdam, Netherlands
354
P5.18.11 - Neutrophil gelatinase B-associated lipocalin - matrix metalloproteinase-9 (NGAL-MMP-9) complex as a surrogate serum marker for mucosal healing in ulcerative colitis
Magali de Bruyn, I. Arijs, W. Wollants, K. Machiels, K. Van Steen, M. Ferrante, S. Vermeire, P. Rutgeerts, G. Opdenakker;
Leuven, Belgium
355
P5.18.12 - Rip-2 mediated control of pathogenic and protective T cell function during chronic colitis
Nichole K. Escalante, M. Cruz Tleugabulova, D. Philpott, T. Mallevaey;
Toronto, Canada
356
P5.18.13 - Significance of IL-9 levels in inflammatory bowel disease
C. Defendenti, Atzeni Fabiola, S. Saibeni, S. Bollani, S. Bruno, P. Almasio, P. Sarzi-Puttini;
Milan, Italy
357
P5.18.15 - Vanin-1 (VNN1), an epithelial pantetheinase that regulates intestinal inflammation
Thomas Gensollen, C. Bourges, F. Galland, P. Naquet;
Marseille, France
358
P5.18.16 - Assessment of loss of response to Infliximab therapy in inflammatory bowel diseases using antibodies
to Infliximab and trough Levels
Luisa Guidi, M. Marzo, G. Andrisani, A. Papa, C. Felice, D. Pugliese, S. Canestri, B. Tolusso, E. Gremese, A. Armuzzi;
Rome, Italy
359
P5.18.17 - Mannose receptor contributes to intestinal inflammation
Sigrid E.M. Heinsbroek, R. Schilderink, A.A. te Velde, S. Gordon, W.J. de Jonge;
Amsterdam, Netherlands
360
P5.18.18 - Microscopic colitis patients demonstrate a mixed Th17/Tc17 and Th1/Tc1 mucosal cytokine profile
Ashok K. Kumawat, H. Strid, C. Tysk, J. Bohr, E. Hultgren Hörnquist;
Orebro, Sweden
361
P5.18.19 - Involvement of mast cells in the development of colitis-associated colon cancer
Young-Mi Lee, M. Xin, D. Kim;
Iksan, Korea, Republic of
362
P5.18.20 - Whey and Soy protein supplements improves body composition in patients with Crohn`s disease
under azathioprine and anti-TNF- α therapy
Júlia F. Machado, V. Oya, C.S.R. Coy, A.M. Morcillo, M.M.S. Vilela;
Campinas, Brazil
216
Posters - August 26
363
P5.18.21 - The role of FIBCD1 in intestinal homeostasis and inflammation
Jesper B. Moeller, A. Schlosser, T. Bak-Thomsen, M. Hammond, L. Dubey, O. Nielsen, G.L. Sorensen, U. Holmskov;
Odense C, Denmark
364
P5.18.22 - Protective role of HLADRB1*04 allele against ulcerative colitis in Iran
Mojgan Mohammadi, M.M. Hayatbakhsh, H. Abdoli Sereshki, M.J. Zahedi, H. Rafatpanah, M. Rastin, A.R. Nicpoor;
Kerman, Iran, Islamic Republic of
365
P5.18.23 - SHIP represses auto-inflammation and is required for intestinal immune homeostasis
Eyler N. Ngoh, S.B. Weisser, H. Brugger, R. Jen, A. Hirschfeld, S. Turvey, L.M. Sly;
Vancouver, Canada
366
P5.18.24 - Multispecific anti-neutrophil cytoplasmic antibodies in chronic inflammatory bowel diseases: what does that
mean?
Branka Nikolic, M. Nikolic, S. Dobric, D. Popovic, S. Andrejevic;
Belgrade, Serbia
367
P5.18.25 - Phenotypic and functional characterization of intraepithelial and lamina propria inflammatory cell infiltrate in
autoimmune enteropathy
Moira Paroni, G. Nizzoli, A. Magarotto, U. Gianelli, C. Ciafardini, D. Conte, S. Abrignani, J. Geginat, F. Caprioli;
Milan, Italy
368
P5.18.26 - Decrypting the role of S1P/SphK axis in the dextran sulphate sodium-mediated colitis in mice
Peter N. Pushparaj, L.A. Damiati, S.D. Kumar, K. Gauthaman, J. Manikandan, M.H. Al-Qahtani;
Jeddah, Saudi Arabia
369
P5.18.27 - Systems immunological strategies to decipher the genomic expression patterns in dextran sulphate
sodium-mediated acute colitis
Peter N. Pushparaj, L.A. Damiati, J. Manikandan, K. Gauthaman, M.H. Al-Qahtani;
Jeddah, Saudi Arabia
370
P5.18.28 - Dissecting the effect of resveratrol in dextran sulphate sodium-mediated colitis in Balb/c mice
Peter N. Pushparaj, S.D. Kumar, L.A. Damiati, J. Manikandan, K. Gauthaman, M.H. Al-Qahtani;
Jeddah, Saudi Arabia
371
P5.18.29 - TL1A/DR3 interaction is associated with pathogenesis of inflammatory bowel disease in adults and children
Tomasz J. Slebioda, P.M. Wierzbicki, M. Stanislawowski, K. Celinski, P. Landowski, B. Kaminska, A. Bojarska-Junak, J. Rolinski, K. Adrych,
Z. Kmiec;
Gdansk, Poland
372
P5.18.30 - Anti-TNF-alpha monoclonal antibody therapy of crohn’s disease is associated with acute reduction of circulating
classical and intermediate monocyte numbers
Stephanie M. Slevin, C. Dennedy, A. Ribeiro, R. Ceredig, M.D. Griffin, L.J. Egan;
Galway, Ireland
373
P5.18.31 - A crude extract of hydatid laminated layer prevents Dextran Sulfate Sodium induced-colitis in mice by Nitric
Oxide Synthase2 down-regulation
Imene Soufli, H. Rafa, M. Amri, R. Toumi, K. Abdelouhab, C. Touil-Boukoffa;
Algiers, Algeria
374
P5.18.32 - Transfer of Myeloid Derived Suppressor Cells from neonatal tolerized IL-10 gene-deficient mice protects
from development of intestinal inflammation
Beate C. Sydora, E.J. Albert, R.R. Foshaug, B.S. Sydora, R.N. Fedorak;
Edmonton, Canada
375
P5.18.33 - Infiximab Simultaneously Restore Foxp3+Treg, Type 1-Like Treg and B cells in IBD
Z. Li, S. Vermeire, D. Bullens, M. Ferrante, K. Van Steen, M. Noman, P. Rutgeerts, J. L. Ceuppens, Gert Van Assche;
Leuven, Belgium
376
P5.18.34 - BCG-specific lymphocyte proliferation and cytokine in patients with Crohn`s disease under anti-TNF- α
and azathioprine therapy.
V. Oya, T. Davanço, C.S.R. Coy, M.T.N. da Silva, T.N. Mazzola, A.M. Morcillo, E.L.C. Pinto, Maria M.S. Vilela;
Campinas, São Paulo, Brazil
377
P5.18.35 - Prevalence of IgA anti-zein antibodies in Mexican patients with celiac disease (CD) and irritable bowel
syndrome (IBS)
L.A. Sanchez-Vargas, J.M. Remes-Troche, G. Mellado-Sanchez, E. Bravo-Sarmiento, Hector Vivanco-Cid;
Veracruz, Veracruz, Mexico
378
P5.18.36 - NDST4 deficiency enhances acute colitis and colitis-associated tumorigenesis in mice
C.Y. Huang, M.H. Tsai, T.M. Jao, S.T. Tzeng, J.X. Lee, W.C. Lo, C.W. Chang, Y.L. Li, Ya C. Yang;
Taipei, Taiwan
P5.19 REPRODUCTIVE IMMUNOLOGY
Session Time: Monday, August 26, 13:20 - 15:00
379
P5.19.01 - HLA antigens and anti-sperm antibody
Gholamreza Azizi, A. Mirshafiey, M. Eslami, S. Namaki;
Karaj, Iran, Islamic Republic of
380
P5.19.02 - Multiple immune accentuations predict implantation failure and mark target group among IVF patients
for intravenous immunoglobulin therapy
Viktor Chernyshov, I. Sudoma, B. Dons’koi, Y. Goncharova;
Kiev, Ukraine
217
Posters - August 26
381
P5.19.03 - Features of the immune response and microbial colonization in children with extremely low birth weight
Guzel Chistyakova;
Yekaterinburg, Russian Federation
382
P5.19.04 - Maternal-fetal immunotolerance from mice with pregnancy loss induced by adoptively transferring exosomes
from T lymphocytes
Cheng Cui, S. Hao, Y. Wang, M. Li, W. Lv;
Shijiazhuang, China
383
P5.19.05 - The predominance of Th17 lymphocytes and decreased number and function of Treg cells are present in preeclampsia
Dorota A. Darmochwal-Kolarz, M. Kludka-Sternik, B. Kolarz, J. Rolinski, J. Oleszczuk;
Lublin, Poland
384
P5.19.06 - Effect of prenatal steroid treatment on the developing immune system
Ines Dipenbruck, C.C. Much, A. Krumholz, R. Thieme, D. Thieme, M. Solano, P.C. Arck, E. Tolosa;
Hamburg, Germany
385
P5.19.07 - HLA-G6 and reproductive immunology
Faramarz Farzad, S. Abediankenari, I. Naghavian;
Sari, Iran, Islamic Republic of
386
P5.19.08 - Automated clustering of flow cytometry data identifies a Th0 population induced by influenza vaccination
in pregnant women
Dzhamala Gilmandyar, D. Roumanes, J. Rebhahn, L. Thornburg, T.R. Mosmann;
Rochester, United States
387
P5.19.09 - Inflammation as a cause of placental dysfunction in high-risk pregnancies
Sylvie Girard, A.E.P. Heazell, H. Derricott, C.P. Sibley, S.M. Allan, R.L. Jones;
Manchester, United Kingdom
388
P5.19.10 - Inhibition of TLR3 mediated direct natural killer cell activation by a macrolide antibiotic clarithromycin
N. Hirohata, S. Komine-Aizawa, Satoshi Hayakawa;
Tokyo, Japan
389
P5.19.11 - The export of T helper cells from thymus during pregnancy
Sandra Hellberg, R.B. Mehta, M. Edström, A. Forsberg, G. Berg, O. Winqvist, M.C. Jenmalm, J. Ernerudh;
Linköping, Sweden
390
P5.19.12 - Expression of LAG-3, but not PD-1, is enriched on double negative T cells at the female genital tract
Jennifer Juno, J. Lajoie, C. Wachihi, M. Kimani, J. Kimani, F. Plummer, K. Fowke;
Winnipeg, Canada
391
P5.19.13 - Reduced inhibitory NK cell receptors expression in women with recurrent spontaneous abortions (RSA)
Vasiliki Kitsiou, S. Dendrinos, K. Psarra, E. Konsta, E. Grigoriou, G. Kreatsas, C. Papasteriades;
Athens, Greece
392
P5.19.14 - Lipid bodies in preimplantation embryo health
Christiana Kyvelidou, G.J. Tserevelakis, G. Filippidis, C. Fotakis, I. Athanassakis;
Heraklion, Greece
393
P5.19.15 - Influence of THP-1 cells on endothelial cells tube formation in the presence of soluble placenta-derived factors
Tatiana Y. Lvova, O.I. Stepanova, K.N. Furaeva, E.A. Potolicina, D.A. Korenkov, S.A. Selkov, D.I. Sokolov;
Saint-Petersburg, Russian Federation
394
P5.19.17 - Effect of high-dose dexamethasone in early pregnancy on pregnancy outcome
Hasan Namdar Ahmadabad, S. Moazzeni, M. Salehnia;
Tehran, Iran, Islamic Republic of
395
P5.19.18 - Genetic polymorphisms of KIR2DL4 and LILRB1 in spontaneous abortion and control women in Polish population
Izabela Nowak, E. Barcz, A. Malinowski, J. Wilczynski, M. Banasik, E. Majorczyk, P. Kusnierczyk;
Wrocław, Poland
396
P5.19.19 - Potential role of circulating microRNAs as a biomarker for unexplained recurrent spontaneous abortion
Weibing Qin, N. Yang, Y. Wang, Z. Miao, R. Cui, X. Wang;
Guangzhou, China
397
P5.19.20 - Pro-inflammatory and anti-inflammatory cytokine production patterns in intra-uterine growth restriction (IUGR)
Raj Raghupathy, M. Al-Azemi Majedah, F. Azizieh;
Faculty of Medicine, Kuwait
398
P5.19.21 - Trophoblast cells induce and recruit iTregs by VIP production and through a TGF beta dependent pathway
L. Fraccaroli, E. Grasso, V. Hauk, G. Mor, C. Perez-Leiros, Rosanna Ramhorst;
Buenos Aires, Argentina
399
P5.19.22 - CD4(+) CD25(high) Foxp3(+) cells increased in the peritoneal fluid of patients with endometriosis
Luiz V. Rizzo, S. Podgaec, L.F. Cordeiro Fernandes, E. Chada Baracat, M. Simoes Abrao;
Sao Paulo, Brazil
400
P5.19.23 - Immune profile of Sudanese women with conception disorders: Possible role for T-helper cytokines
Habab M.A. Saad;
Khartoum, Sudan
401
P5.19.24 - Intravenous immunoglobulin treatment on expanded CD56+ cells in women with recurrent reproductive failure
R. Ramos-Medina, A. Garcia-Segovia, A. Aguraron de la Cruz, J. Gil, J. Carbone, A. Seyfferth, J. Alonso, L. Ortiz-Quintana,
E. Fernandez-Cruz, Silvia Sanchez-Ramon;
Madrid, Spain
218
Posters - August 26
402
P5.19.25 - Expression profiling of vitamin D receptor in reproductive tissues of pregnant mice
Mehdi Shabazi, A.h. Zarnani;
Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of
403
P5.19.26 - Immune cells functional disorder in case of preeclampsia
Dmitry Sokolov, Y. Onohina, V. Mikhaylova, O. Ovchinnikova, D. Korenkov, S. Selkov;
St.Petersburg, Russian Federation
404
P5.19.27 - Influence of placental secretory factors to endothelial cell and monocyte phenotype and monocyte
transendothelial migration activity
Olga I. Stepanova, T. Lvova, K. Furaeva, E. Rebezova, A. Baldin, D. Sokolov, S. Selkov;
Saint Petersburg, Russian Federation
405
P5.19.28 - Parameters of cellular immunity in pregnant women with threatened abortion in early pregnancy, against the
low level of progesterone
Iryna I. Voronova, T.N. Demina;
Donetsk, Ukraine
406
P5.19.29 - Polymorphisms -725 C>G>T, -716 T>G of the HLA-G gene in spontaneous abortion and control women in Polish
population
Marta Wagner, I. Nowak, E. Barcz, A. Malinowski, J. Wilczynski, M. Banasik, A. Wisniewski, E. Wisniewska, P. Kusnierczyk;
Wroclaw, Poland
407
P5.19.30 - Spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin A4 axis
Jie Zhao, X.Z. Ye, Z.H. Feng;
Wuhan, China
408
P5.19.31 - The role of systemic inflammation in the development of pregnancy and obstetric complications
Iuliia Zhuravleva, L. Solomatina, A. Brazhnikov, E. Gusev;
Ekaterinburg, Russian Federation
P5.20 TUMOR IMMUNITY AND IMMUNOSURVEILLANCE
Session Time: Monday, August 26, 13:20 - 15:00
409
P5.20.001 - Anti-tumor specific T-helper cell priming by CIITA-driven MHC-II-positive tumor cells in dendritic cell-depleted
transgenic mice
L. Lombardo, G. Forlani, A. Tedeschi, Roberto S. Accolla;
Varese, Italy
410
P5.20.002 - Domination of Th17 subpopulation of lymphocytes during tumor progression
Maryam Ajami, R. Mansouri, J. Hadjati;
Tehran, Iran, Islamic Republic of
411
P5.20.003 - Relation between Hepatitis B virus DNA load and quantitative HBsAg in HBV infected patient’s sera
Sohrab Alam, A. Afrin, A. Hye, S.K. Saha, S. Choudhury, S.A. Khan, Z.F. Rahman, M. Hossain, M.S. Hassan, I. Mahmud;
Dhaka, Bangladesh
412
P5.20.004 - BRCA1 gene deletions and duplications in Omani Breast cancer cases
Aliya Alansari, K. Al-Mawali, B. Al-Bahrani, M. Al-Moundhri;
Al-Khoud, Oman
413
P5.20.005 - Interplay of Th17/Treg cells in immunopathogenesis of Urothelial carcinoma of bladder
Vivek Anand, S. Chugh, L. Swaroop, A. Seth, A. Sharma;
New Delhi, India
414
P5.20.006 - Association some of the major histocombatibility complex class II alleles with breast cancer among Jordanian
females
Manar F. Atoum, R.Q. Tanashat;
Zarqa, Jordan
415
P5.20.007 - Expression of CD95 and caspases activity in peripheral blood lymphocytes during breast cancer development
Uliana S. Bagina, K.S. Ignatyev, P.I. Kovchur, I.E. Bahlaev, T.O. Volkova;
Petrozavodsk, Russian Federation
416
P5.20.008 - Serum Amyloid A impacts the growth of melanoma cells and may be a link between inflammation and cancer
outcome
Luziane P. Bellé, F.H. Knebel, R.C. Albuquerque, S.S. Maria-Engler, A. Campa;
Sao Paulo, Brazil
417
P5.20.009 - A relationship between soluble MICA and anti-MICA-Abs in nasophayngeal carcinoma patients
Arij Ben Chaaben, H. Abaza, H. Douik, T. Mamoghli, G. Kablouti, L. Harzallah, S. Gritli, D. Charron, F. Guemira, R. Tamouza;
Tunis, Tunisia
418
P5.20.010 - Tertiary lymphoid tissue (TLT) in colorectal cancer: lymph node-like aggregates supporting the immune response
Francesca Bergomas, G. Di Caro, F. Grizzi, A. Doni, P. Bianchi, A. Malesci, L. Laghi, P. Allavena, A. Mantovani, F. Marchesi;
Rozzano (MI), Italy
419
P5.20.011 - Role of ATP and myeloid derived suppressor cells in neuroblastoma microenvironment
Giovanna Bianchi, P. Pellegatti, D. Marimpietri, L. Emionite, I. Marigo, M. Cilli, F. Di Virgilio, V. Bronte, V. Pistoia, L. Raffaghello;
Genoa, Italy
420
P5.20.012 - Antitumor activity of synthetic phosphoethanolamine in experimental melanoma
L.C. Veronez, T.H. Geraldino, C.D. Polli, L.R. Azevedo, D.O. Miranda, R.O. Lopes, D.A. Maria, S.B. Garcia, Gabriela S. Bisson;
Ribeirão Preto, Brazil
219
Posters - August 26
421
P5.20.013 - Proteomic identification of Annexin A4 as a novel renal cell carcinoma associated antigen
Apollinariya V. Bogolyubova, C. Gouttefangeas, D.J. Kowalewski, A.T. Kopylov, A. Stenzl, S.A. Nedospasov, P.V. Belousov;
Moscow, Russian Federation
422
P5.20.014 - Proliferative potential of double positive CD4+/CD8+ T lymphocytes in coculture with tumor cells
Florina M. Bojin, L. Cernescu, A. Cean, G. Tanasie, C. Panaitescu, V. Paunescu;
Timisoara, Romania
423
P5.20.015 - Cis-acting genetic elements at or near the Pas1 locus control Kras2 mutations and gene expression
in lung tumors from mice selected for acute inflammatory response
Andrea Borrego, A. Galvan, J.R. Jensen, W. Cabrera, O.G. Ribeiro, N. Starobinas, M. De Franco, O.M. Ibañez, G. Manenti, T.A. Dragani;
São Paulo, Brazil
424
P5.20.016 - Inhibition of cell cycle progression and apoptotic activity of Ganoderma lucidum in oral cancer cell lines
Marinela Bostan, M. Mihaila, G. Matei, L. Brasoveanu;
Bucharest, Romania
425
P5.20.017 - Urethane-induced lung cancer and associated events
D. Teixeira, G.N. Gomes, A.E. Hirata, Valquiria Bueno;
São Paulo, Brazil
426
P5.20.018 - SIGIRR as a novel HER2-Regulated gene in breast tumors
Luis Felipe I. Campesato, A.M. Silva, F.C.P. Navarro, M. Marçola, R.P. Markus, A. Lepique, E.T. Costa, A.A. Camargo;
São Paulo, Brazil
427
P5.20.019 - ANGPTL4 is involved in the metastatic hepatoma cells’ survival in the third microenvironment
Lili Cao, L. Han, Z. Zhang, W. Sun;
Jinan, China
428
P5.20.020 - Identification of Early Pancreatic Cancer-Associated Autoantibodies in Mouse and Human
Michela Capello, S. Ferri-Borgogno, P. Cappello, W. Zhou, G. Mandili, I. Sperduti, F.C. Linty, G. Maruccio, M. Milella, F. Novelli;
Turin, Italy
429
P5.20.021 - CD4+CD25highFoxP3+ regulatory T lymphocytes in peripheral blood of gastric cancer patients during
chemoradiotherapy
Agata Chwieduk, A. Gdowicz-Kłosok, A. Namysł-Kaletka, P. Polanowski, R. Kawczynski, J. Wydmanski;
Gliwice, Poland
430
P5.20.022 - Dendritic cells from mesothelioma patients are numerically and functionally impaired
Scott M. Cornwall, M. Wikstrom, A. Nowak, J. Alvarez, D. Nelson;
Bentley, Australia
431
P5.20.023 - High proportion of PMN-MDSCs within primary tumors correlates with disease aggressiveness in melanoma
Laetitia Douguet, A. Pommier, R. Lengagne, M. Avril, B. Lucas, A. Prevost Blondel;
Paris, France
432
P5.20.024 - IL-18-Binding Protein (BP) is expressed in human ovarian cancer and may limit IL-18 activity
Silvano Ferrini, G. Carbotti, M. Fabbi, A. Orengo, A. Brizzolara, G. Barisione, D. Mezzanzanica, P. Pinciroli, M. Bagnoli, I. Airoldi;
Genoa, Italy
433
P5.20.025 - Proteolytic machinery involved in MICA and MICB processing in cervical Cancer
Mariel Garcia-Chagollan, M.R. Bueno-Topete, S. Fujimura-Hernandez, R.A. Franco-Topete, B.E. Bastidas Ramirez, M. Fafutis-Morris,
S. del Toro-Arreola;
Guadalajara, Mexico
434
P5.20.026 - Analysis of lymphocyte subpopulations in blood from gastric cancer patients during radiotherapy
Agnieszka Gdowicz-Klosok, A. Chwieduk, A. Namysł-Kaletka, R. Kawczynski, P. Polanowski, J. Wydmanski;
Gliwice, Poland
435
P5.20.027 - Involvement of the long pentraxin PTX3 in skin carcinogenesis
Stefania Gentile, E. Bonavita, N. Polentarutti, F. Pasqualini, F. Feruglio, S. Tartari, M. Nebuloni, T. Schioppa, A. Mantovani, C. Garlanda;
Rozzano, Italy
436
P5.20.028 - Intra-tumoral B cells are able to organize into tertiary lymphoid structures and to develop a protective humoral
immune response in lung cancer patients
Claire Germain, F. Tamzalit, S. Knockaert, S. Gnjatic, P. Validire, R. Remark, D. Damotte, W.H. Fridman, C. Sautes-Fridman,
M.C. Dieu-Nosjean;
Paris, France
437
P5.20.030 - The heterogeneity of lung metastasis immune microenvironment according to the primary tumor location
Nicolas A. Giraldo, R. Remark, A. Lupo, D. Damotte, M. Alifano, I. Cremer, M.C. Dieu-Nosjean, C. Sautès-Fridman, W.H. Fridman;
Paris, France
438
P5.20.031 - Azacytidine and Everolimus therapy reduces the high frequency of terminally differentiated CD38+HLADR- CD8
T cells in relapsed AML patients
Chindu Govindaraj, P. Tan, P. Walker, A. Spencer, A. Wei, M. Plebanski;
Melbourne, Australia
439
P5.20.032 - Panobinostat in combination with azacitidine reduces the frequency of TNFR2+ Tregs in newly diagnosed
acute myeloid leukemia patients
Chindu Govindaraj, P. Tan, P. Walker, A. Wei, A. Spencer, M. Plebanski;
Melbourne, Australia
440
P5.20.033 - The effects of Cancer Associated Fibroblasts on mechanisms of immune evasion in a rat chemical mammary
carcinoma model
Gurcan Gunaydin, Y. Dolen, N. Unver, S. Kesikli, D. Guc;
Ankara, Turkey
220
Posters - August 26
441
P5.20.034 - Effects of Silymarin on frequency and function of Myeloid-derived suppressor cells in animal model of tumor
Morteza Hafezi, A. Namdar, N. Khosravianfar, A. Razavi, J. Hadjati;
Tehran, Iran, Islamic Republic of
442
P5.20.035 - Formation of vascular mimicry in human gastric cancer and the corelation with LOX and MMP-9
Mei Han, Y. Cao, H. Sun, R. Bai;
Yinchuan, China
443
P5.20.036 - Aberrant expression of circulating PD-L1+CD14+HLA-DR-/low cells in esophageal squamous cell carcinoma
patients: Immunosuppressive characteristics and tumor clinical relevance
Haitao Huang, G. Zhang, G. Li, H. Ma, X. Zhang;
Suzhou, China
444
P5.20.037 - Microparticles: a road to antitumor immunity
Bo Huang;
Beijing, China
445
P5.20.038 - Mapping on chromosome 17 a novel major locus determining kidney cancer susceptibility in mice
J.R. Jensen, A. Galvan, M. Colecchia, W.H.K. Cabrera, O.G. Ribeiro, N. Starobinas, A. Borrego, M. De Franco, T.A. Dragani,
Olga M. Ibañez;
São Paulo, Brazil
446
P5.20.039 - Anti-tumor effect of BCG-LM via activated eosinophils.
Toshihiro Ito, I. Yano, T. Nakayama;
Chiba, Japan
447
P5.20.040 - Inducible nitric oxide synthase from prostate cancer stem/initiating cells inhibits T cell priming
Elena Jachetti, M. Grioni, S. Mazzoleni, C. Brambillasca, R. Galli, M. Bellone;
Milan, Italy
448
P5.20.041 - Inflammatory stress upregulates chemokine expression in uveal melanoma cell lines and increases monocyte
migration
Tina Jehs, H.B. Juel, C. Faber, I.H.G. Bronkhorst, M.J. Jager, M.H. Nissen;
Copenhagen, Denmark
449
P5.20.042 - Interleukin-33/ST2 Axis Promotes Breast Cancer Progression and Angiogenesis by Intratumoural Accumulation
of Immunosuppressive and Natural Helper Cells
Ivan Jovanovic, N. Pejnovic, G. Radosavljevic, J. Pantic, M. Milovanovic, N. Arsenijevic, M. Lukic;
Kragujevac, Serbia
450
P5.20.043 - The role of memory T lymphocytes during growth of SL2 tumours in DBA/2 mice
Jurgita Jursenaite, I. Girkontaite, M. Mauricas, D. Characiejus;
Vilnius, Lithuania
451
P5.20.044 - Myeloma with biclonal IgG lambda and IgD kappa in serum : a case report
Sana Khlif, H. Hachicha, S. Ben jemaa, S. Feki, M. Medhaffer, M. Ben Ayed, S. Baklouti, M. Elloumi, H. Masmoudi;
Sfax, Tunisia
452
P5.20.045 - Effect of SAA1, SAA2 and SAA4 knockdown on proliferation and invasion of glioblastomas multiformes cells
Franciele H. Knebel, L.P. Bellé, R.B. Haga, G.H. Kaihami, A. Campa;
São Paulo, Brazil
453
P5.20.046 - Inactivation of tumor-specific CD8+ CTLs within tumor-infiltrating lymphocytes by tumor-infiltrating
immunosuppressive tolerogenic dendritic cells
Hideki Kogo, H. Harimoto, M. Shimizu, T. Date, Y. Nakagawa, K. Nakatsuka, A. Wakabayashi, C. Sakamoto, E. Uchida, H. Takahashi;
Tokyo, Japan
454
P5.20.047 - Systemic changes of cellular immune parameters as observed in patients with preinvasive/invasive cervical
cancer before and after treatment
Olga V. Kurmyshkina, P.I. Kovchur, I.E. Bakhlaev, T.O. Volkova, A.N. Poltorak;
Petrozavodsk, Russian Federation
455
P5.20.048 - Repurposing Na+/K+ pump blockers for in vitro suppression of tumor development
Radu Lazarovicz, M. Toma, O. Gavriliuc, L. Marusciac, A. Gruia, C. Tatu, G. Tanasie, C. Panaitescu, F. Bojin, V. Paunescu;
Timisoara, Romania
456
P5.20.049 - Down-regulation of EMT signal and invasive properties of colon cancer cells by SOCS1
Choong-Eun Lee, W. Kim, S. Ahn, B. Yoo;
Suwon, Korea, Republic of
457
P5.20.050 - B7-H4 modulates anti-tumor responses by limiting immunosuppression in the tumor microenvironment
Joanne Leung, W. Suh;
Montreal, Canada
458
P5.20.051 - DcR3 gene polymorphisms are associated with sporadic breast infiltrating ductal carcinoma in chinese
northeast women:a case control study
Z. Fu, D. Li, S. Chen, Dianjun Li;
Harbin, China
459
P5.20.052 - HVEM gene polymorphisms are associated with sporadic breast cancer in Chinese women
Dianjun Li, D. Li, Z. Fu, S. Chen;
Harbin, China
460
P5.20.053 - Association of LTBR gene polymorphisms with sporadic infiltrative duct carcinoma in northeast Chinese Han
population
S. Chen, W. Yuan, Z. Fu, Dianjun Li;
Harbin, China
221
Posters - August 26
461
P5.20.054 - Association Analysis between HLA-DRB1 Allelic Polymorphisms and Age to Identify Genes Promoting the Early
Onset of Solid Cancers
Hui Liu;
Dalian, China
462
P5.20.055 - HLA-E is expressed and functional in melanoma but not melanocytes
Elisa Lo Monaco, E. Tremante, P.G. Natali, M. Mottolese, P. Visca, M. Benevolo, P. Giacomini;
Roma, Italy
463
P5.20.056 - Dendritic cell density and HMGB1 expression in non-small cell lung carcinomas
Jose S. Lopez-Gonzalez, D. Aguilar-Cazares, M. Meneses-Flores, H. Prado-Garcia, V. Rojo-Leon, L. Islas-Vazquez;
Mexico city, Mexico
464
P5.20.057 - Studies on immunogenetic mechanism of hepatocellular carcinoma caused by Fas gene polymorphism
Haiting Mao, J. Zhang, Y. Yang, J. Sun, C. Ma, W. Gao, B. Song, Q. Shao, X. Qu;
Jinan, China
465
P5.20.058 - Identification and characterization of candidate MDSCs in PBMCs of patients with lymphoproliferative malignancies
Olivia Marini, M.A. Cassatella, G. Pizzolo, P. Scapini, C. Tecchio;
Verona, Italy
466
P5.20.059 - Degree and organization pattern of lymphocyte populations within the active border of human colorectal
cancer liver metastases: association between immunological imprint and survival
Anastasia Meshcheryakova, D. Tamandl, M. Svoboda, E. Bajna, J. Stift, D. Heiden, T. Grünberger, E. Jensen-Jarolim, M. Bergmann,
D. Mechtcheriakova;
Vienna, Austria
467
P5.20.060 - Melanoma cells produce adenosine through a CD38/CD73 pathway and suppress CD4+ T cell proliferation
Fabio Morandi, A.L. Horenstein, B. Morandi, P. Carrega, A. Chillemi, G. Zaccarello, M.C. Mingari, V. Pistoia, F. Malavasi;
Genoa, Italy
468
P5.20.061 - Nasopharyngeal carcinoma-derived exosomes recruit, expand and up-regulate biological activities
of human regulatory T cells
Dhafer Mrizak, O. Moralès, N. Martin, Y. De Launoit, P. Busson, N. Delhem;
Lille, France
469
P5.20.062 - Evaluation of the use of the CA-15-3 in monitoring of Breast cancer in A B U teaching hospital, Zaria, northern
Nigeria
Bolanle O.P. Musa, D.A. Dawotola, L.M.D. Yusufu, V.I. Odigie;
Zaria, Nigeria
470
P5.20.063 - Prediction of Radix Astragali immunomodulatory effects of CD80 expression on THP-1 cells
from chemical chromatograms by Quantitative Pattern-Activity Relationship (QPAR)
Chun-har Michelle Ng, T. Lau, K. Fan, Q. Xu, F. Chau, M. Sze;
Hong Kong, Hong Kong
471
P5.20.064 - Myeloid-derived suppressor cells attenuate Th1 development through IL-6 production to promote tumor
progression
H. Tsukamoto, S. Senju, Yasuharu Nishimura;
Kumamoto, Japan
472
P5.20.065 - Evaluation of a hydroalcoholic extract of Uncaria tomentosa on dendritic cells and Th1/Th2/Th17 profile, IL-12
in breast cancer patients
C.E. Nuñez, Cesar E. Nuñez, I.A. Lozada-Requena, T.P. Ysmodes, S.R. Davila, Y.P. Alvarez, C. Ocampo, J.L. Aguilar Olano;
Lima, Peru
473
P5.20.066 - Allelic variants in promoter region of FOXP3 gene as a protective factor in breast cancer development
Julie M.M. Oda, K.B. de Oliveira, R.L. Guembarovski, C.E.C. de Oliveira, P.M.M. Ozawa, B.K.B. Hirata, C.B. Ariza, C.Z. Campos,
D.R. Derossi, M.A.E. Watanabe;
Londrina, Brazil
474
P5.20.067 - Modeling leukemia immunoediting in mouse-human chimeras
Giacomo Oliveira, C. Toffalori, J.M. Garcia-Manteiga, B. Camisa, A. Bondanza, E. Stupka, F. Ciceri, K. Fleischhauer, C. Bonini, L. Vago;
Milano, Italy
475
P5.20.068 - Breast and kidney-expressed chemokine (CXCL14) in breast cancer
Zhou Luo Ou, X. Gu, F. Lin, X. Yang, Y. Guo, Z. Shao;
Shanghai, China
476
P5.20.069 - Role and potential application of chemokine-binding proteins in breast cancer
Zhou Luo Ou, X. Zeng, F. Lin, X. Yang, Y. Guo, Z. Shao;
Shanghai, China
477
P5.20.070 - Genetic variation in DNA repair genes: ERCC4 and XRCC3 and cervical squamous cell carcinoma risk
Edyta A. Pawlak-Adamska, M. Bartosinska, I. Wlodarska-Polinska, A. Ignatowicz-Pacyna, J. Kornafel, I. Frydecka;
Wroclaw, Poland
478
P5.20.071 - Silencing of claudin-10 expression on B-1 cells impaired the increased metastatic behavior of melanoma cells
an in vitro coculture system
Elizabeth C. Pérez, P. Xander, M.F. Laurindo, R. Novaes e Brito, B. Vivanco, L. Osugui, M. Mariano, J.D. Lopes;
São Paulo, Brazil
479
P5.20.072 - Role of STAT3 signaling in MDSC-mediated immune suppression
Laura Pinton, S. Solito, L. Perilli, V. Damuzzo, S. Francescato, P. Zanovello, V. Bronte, S. Mandruzzato;
Padova, Italy
222
Posters - August 26
480
P5.20.073 - Inhibition of Th17 cells and induction of regulatory T cells is mediated by SOCS-1 in the tumor microenvironment
of breast cancer patients
Arash Pourgholaminejad, R. Eftekhari, R. Mirzaei, J. Hadjati;
Tehran, Iran, Islamic Republic of
481
P5.20.074 - Characterization of Th17 cells and regulatory T cells in pleural effusions of lung cancer patients
Heriberto Prado-Garcia, S. Romero-Garcia, J. Orozco-Gaytan, J.S. Lopez-Gonzalez, A. Arreola-Morales;
Mexico City, Mexico
482
P5.20.075 - Expression of at least one desmoglein is essential for multicellular tumor spheroid (MCTS) formation
Alexander V. Prokhorov, E.V. Svirshchevskaya;
Moscow, Russian Federation
483
P5.20.076 - Polyomavirus BK large tumor antigen exerts tolerogenic signatures with immunodominant p53-binding
regions in prostate cancer
Maurizio Provenzano;
Zurich, Switzerland
484
P5.20.077 - Role of G-protein coupled receptor 120 in tumor-promotion of human colorectal cancer
Q. Wu, Liu Qian, M. Jin, J. Liu, Y. Zhang;
Shanghai, China
485
P5.20.078 - Role of ectoenzymes in the interaction between myeloma, bone cells and immune effectors: the potential role
of adenosine and the oxytocin/oxytocin receptor
Valeria Quarona, M. Lazzaretti, A. Chillemi, A. Zito, G. Zaccarello, A.L. Horenstein, F. Saccucci, V. Pistoia, N. Giuliani, F. Malavasi;
Torino, Italy
486
P5.20.079 - Mesenchymal sterm cells (MSCs) in head and neck squamous cell cancer (HNSCC)
Valentina Querci, V. Santarlasci, L. Maggi, M. Capone, M. Rossi, L. Cosmi, F. Liotta, F. Annunziato;
Florence, Italy
487
P5.20.080 - Defective IL-23/IL-17 axis protects p47phox-/- mice from colon cancer
Cornelia Richter, J. Bandola, M. Herrero San Juan, B. Weigmann, H. Bonig, S. Brenner, H.H. Radeke;
Dresden, Germany
488
P5.20.081 - Epigenetic modifications of the long pentraxin PTX3 in human colorectal cancer
Marcello Rubino, C. Greco, S. Vetrano, E. Barbati, L. Laghi, R. Papait, A. Mantovani, C. Garlanda;
Rozzano (MI), Italy
489
P5.20.082 - Targeting colon cancer cell NF-кB regulates tumor-associated macrophage polarization and enhances anti-tumor
immune response
A.E. Ryan, A. Colleran, A. O’Gorman, L. O’Flynn, J. Pindjacova, P. Lohan, M. Nosov, C. Mureau, M.D. Griffin, L.J. Egan, Oliver Treacy;
Galway, Ireland
490
P5.20.083 - Tumor-specific Th17 cells orchestrate anti-tumoral responses
Juan J. Sáez, S. Nuñez, F. Flores, D. Fernández, M. Rosemblatt, M.R. Bono, D. Sauma;
Santiago, Chile
491
P5.20.084 - The Inhibitory effects of Metformin on tumor cell growth in hypoxia conditions
Zohreh Safari, M.H. Seyedzadeh, A. Zare, J. Arasteh, R. Safaralizadeh, G.A. Kardar;
Tabriz, Iran, Islamic Republic of
492
P5.20.085 - Cooperation between adenosinergic and hypoxic axes in chronic lymphocytic leukemia cells (CLL)
Sara Serra, T. Vaisitti, A.L. Horenstein, F. Malavasi, S. Deaglio;
Torino, Italy
493
P5.20.086 - Oxidative stress induces a temporary initial decrease of HSP70 content in EL4 lymphoma cells
Olga Shustova, A. Boyko, A. Klinkova, N. Troyanova, E. Kovalenko, A. Sapozhnikov;
Moscow, Russian Federation
494
P5.20.087 - Cancer/testis antigen HCA587 promotes the metastatic behavior of melanoma cells
Xiao Song, J. Hao, J. Chen, W. Song, Y. Li, Y. Zhang, Y. Yin;
Beijing, China
495
P5.20.088 - Immunophenotypes of Burkitt’s lymphoma cell lines alter at different EBV infection latency types
Irina Spaka, A. Spaks, S. Kozireva, J. Osmjana, M. Upmane, R. Birkenfelde, V. Kalnina, S. Lejniece, I. Kholodnyuk;
Riga, Latvia
496
P5.20.089 - CD11b+Ly6G+Ly6Cint myeloid-derived suppressor cells become expanded by medroxiprogesterone acetate
in mammary tumor bearing hosts and suppress NK cell effector functions
R.G. Spallanzani, T. Dalotto, D. Avila, A. Ziblat, C. Domaica, M. Fuertes, X. Raffo Iraolagoitia, G. Rabinovich, M. Salatino,
Norbeto Walter Zwirner;
Buenos Aires, Argentina
497
P5.20.090 - IL-12p40, IL-23 and IL-10 production from monocytes of patients with colorectal cancer: effect of inhibition
of JNK signaling pathway
Noyko S. Stanilov, S.A. Stanilova, Z. Dobreva;
Stara Zagora, Bulgaria
498
P5.20.091 - Association of -1082 A/G promoter polymorphism of IL-10 gene with colorectal cancer development
Noyko S. Stanilov, J.P. Jovchev, L.D. Miteva, Z.G. Dobreva, T.S. Deliysky, A.V. Avramova, S.A. Stanilova;
Stara zagora, Bulgaria
499
P5.20.092 - Can humoral immunity enhance development of skin tumors?
A.A. Lavezo, L.R. Carvalho, T. Canhamero, A. Borrego, W.H.K. Cabrera, J.R. Jensen, M. De Franco, O.G. Ribeiro, O.M. Ibañez, Nancy Starobinas;
São Paulo, Brazil
223
Posters - August 26
500
P5.20.093 - CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer
Yu Su, Y. Lin, L. Zhang, B. Liu, X. Wang, H. Li, X. Xing, X. Cheng, B. Dong, Y. Hu;
Beijing, China
501
P5.20.094 - Essential involvement of tumor-derived IDO in ovarian cancer progression
Yuko Tanizaki, A. Kobayashi, T. Yahata, M. Yamamoto, M. Shiro, Y. Mabuchi, S. Minami, M. Nosaka, T. Kondo, K. Ino;
Wakayama, Japan
502
P5.20.095 - Immune profiling of lung cancer tissues associated with COPD
Elena Tassi, C. Vegetti, P. Baldassari, A. Molla, G. Sozzi, U. Pastorino, A. Anichini;
Milan, Italy
503
P5.20.096 - Targeted-Therapy attenuates local and systemic immune suppression in Solitary Fibrous Tumor patients
Marcella Tazzari, T. Negri, F. Rini, B. Vergani, C. Camisaschi, A. Villa, S. Stacchiotti, L. Rivoltini, S. Pilotti, C. Castelli;
Milan, Italy
504
P5.20.097 - Flow cytometric analysis of the tumour microenvironment during immune mediated tumour rejection
or persistence
Alexandra M. Terry, A. Buckley, J. Holst, B. Fazekas de St Groth, E. Shklovskaya;
Camperdown, Australia
505
P5.20.098 - Antitumor and immunological effects of Nilotinib combined with Interleukin-2 in the B16 melanoma model
involve IFN-g producing CD27+ NK cells
K. Geisler, A. Reischer, B. Jacobs, I. Kroeger, K. Meinhardt, R. Bauer, A. Mackensen, B. Ryffel, Evelyn Ullrich;
Frankfurt, Germany
506
P5.20.100 - Tumors with processing defects display novel tumor antigens via the non-classical HLA-E
E. Doorduijn, C. Oliveira, B. Querido, M. Sluijter, Thorbald van Hall;
Leiden, Netherlands
507
P5.20.101 - NLRP3 inflammasome activation is involved in breast cancer cell death in vitro
Nathalia M. Vasconcelos, R.S. Fontenele, B.C. Guido, K.G. Magalhães, J.R. Correa;
Brasília, Brazil
508
P5.20.102 - Influence of natural killer cells in mammary tumor in female dogs
A. Matsui, M.B. Bandarra, G.M. Magalhães, P.R.R. Moreira, A.C. Alessi, D.P. Munari, Rosemeri O. Vasconcelos;
Jaboticabal, Brazil
509
P5.20.103 - Antitumor activity of synthetic phosphoethanolamine in experimental colon cancer
Luciana C. Veronez, L.R. Azevedo, D.O. Miranda, T.H. Geraldino, R.O. Lopes, S.B. Garcia, G.S. Bisson;
Ribeirão Preto, Brazil
510
P5.20.104 - CCR5-expressing B-1 cells attract CD8 T cells to melanoma millieu and decrease tumor aggressiveness
Bruno C. Vivanco, J.D. Lopes, E. Perez, P. Xander, M. Guereschi, F.T.d. Konno;
São Paulo, Brazil
511
P5.20.105 - Devil Facial Tumour Disease, a devil of a cancer that is transmissible and fails to induce an immune response
Greg M. Woods, A. Kreiss, H. Siddle, L. Howson, T. Kobayashi, G. Brown, C. Tovar, J. Murphy, L. Corcoran, J. Kaufman;
Hobart, Australia
512
P5.20.106 - Co-existence of HLA class I expression and CD8+ T cell infiltration is associated with favorable clinical
outcomes in Ewing’s sarcoma family of tumors (ESFT)
Hiroki Yabe, T. Tsukahara, S. Kawaguchi, T. Torigoe, N. Sato, H. Morioka, H. Yabe;
Saitama City, Japan
513
P5.20.107 - The Immunology of Ovarian Cancer
Anhar Yassin;
Edinburgh, United Kingdom
514
P5.20.108 - Critical role of interleukin-27 in tumor immunology
Zhinan Yin;
Tianjin, China
515
P5.20.109 - The role of the CXCR3 receptor ligand system in the immune escape of multiple myeloma
Claudia Zelle-Rieser, S. Thangavadivel, M. Lechner, A. Brunner, R. Greil, K. Jöhrer;
Innsbruck, Austria
516
P5.20.110 - A Novel Subset of Tumor-infiltrating B7-H3+CD14+HLA-DR-/low Myeloid-derived Suppressor Cells Foster
Immune Privilege and Tumor Progression in NSCLC
Guangbo Zhang, H. Huang, X. Zhang;
Suzhou, China
P6.09 VACCINE ADJUVANTS
Session Time: Monday, August 26, 13:20 - 15:00
517
P6.09.01 - Commensal bacteria-derived membrane vesicles supress Th-1 dominated immune responses in vaccinated and
tumor-bearing mice
Esin Alpdundar, S. Yildiz, B. Bayyurt, M. Ozcan, G. Gucluler, D. Bayik, B. Gungor, I. Gursel, M. Gursel;
Ankara, Turkey
518
P6.09.02 - Immunomodulatory cytokine gene expression profiles and lymphoprolifration response in hamsters vaccinated
by leptospiral vaccine with several adjuvants
Reza Banihashemi, M. Tebianian, J. Majidi, B. Baradaran, A. Jabbari, K. Tadayyon, S. Jalali, M. Sekhavati, R. Ghaderi, G. Shokri;
Tehran, Iran, Islamic Republic of
224
Posters - August 26
519
P6.09.03 - Intradermal and subcutaneous adjuvant effects of type I enterotoxigenic Escherichia coli (ETEC) heat-labile toxin
derivatives
Catarina J.M. Braga, J.F. Rodrigues, S.B. Boscardin, L.C.S. Ferreira;
São Paulo, Brazil
520
P6.09.04 - Investigating Layered Double Hydroxides (LDHs) as Designer Inorganic Vaccine Adjuvants
Hannah C. Buckley, S. Preston, G. Williams, O. Rysnik, D. Lunn, B. Lambrecht, D. O’Hare, J. Austyn;
Oxford, United Kingdom
521
P6.09.05 - A novel allergen-adjuvant conjugate suitable for allergen-specific Th2 redirection
E. Cardilicchia, Lucia Filì, A. Casini, L. Maggi, C. Manuelli, E. Occhiato, F. Boscaro, S. Romagnani, E. Maggi, P. Parronchi;
Florence, Italy
522
P6.09.06 - Helix pomatia Hc (HpH) hemocyanin as protein-carrier and bio-adjuvant of bacterial and viral proteins
Stela Chausheva, V. Gesheva, N. Mihaylova, K. Idakieva, L. Doumanova, A. Tchorbanov;
Sofia, Bulgaria
523
P6.09.07 - Novel vaccine adjuvant for induction of cellular and humoral immunity
Sandrine Crabe, J. Nitcheu, V. Serra;
Evry, France
524
P6.09.09 - Long-term antigen-specific antibody responses against RSV glycoprotein by an osmotic active nanocarrier via
enhanced phagocytosis
Jannatul Firdous, M.A. Islam, S. Park, B. Shim, M. Song, J. Chang, D. Boraschi, S. Han, C. Cho, C. Yun;
Seoul, Korea, Republic of
525
P6.09.10 - Autologous hsp70 enhances the expression of adhesion, fusion receptors, HLA and costimulatory molecules on
murine peritoneal macrophages in a T cell lymphoma
Pramod K. Gautam, P. Deepak, S. Kumar, A. Acharya;
Varanasi, India
526
P6.09.11 - Mast cells redirect the differentiation of dendritic cells away from tolerance and towards immunogenicity
S. Karaki, F. Capel, A. Biola-Vidamment, T. Barbin, G. Schlecht-Louf, T. Tran, M. Dy, M. Arock, F. Bachelerie, Veronique Godot;
Creteil, France
527
P6.09.12 - Adjuvant potential of QS-21 on protective efficacy of DPT vaccine
Camy Goyal, S. Mishra, M. Gautam, S. Gairola, B. Patwardhan;
Lalru, India
528
P6.09.13 - An adjuvant, fungal immunomodulatory protein (FIP)-fve, potentiates the immune response by engaging the
co-stimulatory molecules, CD27 and CD134 (OX-40)
Ong Haris, K. I-Chun, H. Chiung-Hui;
Singapore, Singapore
529
P6.09.14 - SCE 350ET: A plant derived adjuvant inducing Th1 and Th2 type immune response
Bindhya Jayashankar, K.P. Mishra, D. Singh, S. Murthy, R.K. Tulswani, K. Udayasankar, K. Mishra, L. Ganju, S.B. Singh;
Delhi, India
530
P6.09.15 - Oligomannose-coated liposome as a novel antigen-delivery vehicle and an adjuvant for induction of cellular
immune responses
Naoya Kokima, M. Ishii, Y. Kawauchi;
Hiratsuka, Japan
531
P6.09.16 - Fucoidan effect on mononuclear leukocyte immunophenotype and lymphoid organ morphology in mice
Olga V. Lebedinskaya, E.A. Lebedinskaya, N.K. Akhmatova, I.D. Makarenkova;
Perm, Russian Federation
532
P6.09.17 - Chitosan effect on the inactivated influenza vaccine immunogenicity
N.K. Akhmatova, S.S. Markushin, E.A. Akhmatov, L.A. Geiderova, E.V. Sorokina, N.P. Utkina, E.A. Ilinykh, Olga V. Lebedinskaya;
Perm, Russian Federation
533
P6.09.18 - Functional and immunophenotype characteristics of peripheral blood mononuclear leukocytes from healthy
donors under sodium nucleinate effect
Olga V. Lebedinskaya, E.A. Lebedinskaya, N.K. Akhmatova;
Perm, Russian Federation
534
P6.09.19 - Studies with novel synthetic immunogens as a tool for efficient antibody generation
J. Malik, G. Dunau, G. Casi, C. Cattaneo, C. Fessele, M. Soukupova, S. Dziadek, Valeria Lifke;
Penzberg, Germany
535
P6.09.20 - EDA-streptavidin fusion protein conjugated to biotinylated HCV-NS3 protein for the induction of T cell immune
responses against NS3
Teresa Lozano, L. Arribillaga, L. Villanueva, M. Gorraiz, M. Durantez, N. Casares, F. Borras-Cuesta, P. Sarobe, J. Prieto, J. Lasarte;
Pamplona, Spain
536
P6.09.21 - Development of a new microparticle vaccine adjuvant with the ability to deliver peptides to dendritic cells
Francesco Mainini, S. Young, D. Larsen, G. Webster, M. Eccles;
Dunedin, New Zealand
537
P6.09.22 - PolyICLC increases the immunogenicity and efficacy of the filovirus virus-like particle (VLP) vaccine
Karen O. Martins, T.K. Warren, J. Wells, A. Bergeron, J. Steffens, S. van Tongeren, S. Bavari;
Frederick, United States
538
P6.09.23 - Physicochemical and immunological parameters of the anti-allergic adjuvanted vaccine PROLINEM-DS
Arelis Más Quintero, W. Ramírez, A. Labrada, Y. Oliva, M. Mateo, V. Bourg, D. Torralba, J. Llama;
Mayabeque, Cuba
225
Posters - August 26
539
P6.09.24 - Immunogenic and adjuvant properties of OmpS1 and OmpS2 porins
Mario A. Moreno-Eutimio, R. Pastelin-Palacios, C. Perez-Shibayama, C. Gil-Cruz, M. Fernández-Mora, A. Isibasi, E. Calva,
C. Lopez-Macias;
Mexico City, Mexico
540
P6.09.25 - The role of alum-induced host DNA release in antigen-presenting cell activation and T cell priming
Laura E. Noges, A.S. McKee, J. Kappler, P. Marrack;
Denver, United States
541
P6.09.26 - Salmonella typhi porins are adjuvants on the specific immune responses to co-inmunized antigens
Marisol Pérez-Toledo, R. Pastelin-Palacios, C. Gil-Cruz, C. Pérez-Shibayama, M. Moreno-Eutimio, A. Cunningham, M. Pérez-Tapia,
L. Bonifaz, A. Isibasi, C. López-Macías;
Mexico City, Mexico
542
P6.09.27 - Therapeutical effects of a novel nDer p2-conjugated TLR7 in a mouse model of lung inflammation
Sara Pratesi, F. Nencini, G. Petroni, P. Parronchi, E. Maggi, A. Vultaggio;
Florence, Italy
543
P6.09.28 - Inhibitory effects of silibinin on invasive properties of human breast cancer cell line, MDA-MB-231, through
suppression of the proteolytic cascade of cathepsin B/ urokinase-type plasminogen activator
Shahrzad Rahimifar, M. Yousefi, M. Momeny, A. Emami;
Tehran, Iran, Islamic Republic of
544
P6.09.29 - Effective mucosal protection against sexually-transmitted viral infections is provided by MEC/CCL28
Veronica Rainone, G. Dubois, L. Gissmann, V. Temchura, K. Uberla, M. Nebuloni, D. Trabattoni, F. Veas, M. Clerici;
Milan, Italy
545
P6.09.30 - Adjuvants as possible solution to polysaccharide unconjugated vaccines
B. Romeu, M. Lastre, M. Cuello, O. Cabrera, E. González, D. González, A. Mandariote, L. García, D. Cardoso, Oliver Pérez;
Havana, Cuba
546
P6.09.31 - Influence of phosphate salts and alum content on to the immunogenicity and stability
of a Dermatophagoides siboney adjuvanted vaccine
Roxana Samalea, W. Ramírez, B. Tamargo, D. Torralba, A. Morejón, D. Martínez, A. Más, J.F. Infante, V. Bourg, A. Labrada;
Mayabeque, Cuba
547
P6.09.32 - GM-CSF enhances the cellular immune response elicited by a DNA vaccine against HIV even in a low dose approach.
Vinicius C. Santana, R.R. Almeida, S.P. Ribeiro, D.S. Rosa, J. Kalil, E. Cunha-Neto;
São Paulo, Brazil
548
P6.09.33 - Proteus mirabilis flagellin, neither a good adjuvant nor a protective antigen against urinary tract infection
Paola Scavone, A. Umpiérrez, A. Rial, J.A. Chabalgoity, P. Zunino;
Montevideo, Uruguay
549
P6.09.34 - Circulating influenza-specific CD4+ ICOS1+ IL-21+ expand after vaccination, exert helper function
and predict antibody responses in humans
Fabiana Spensieri, E. Borgogni, L. Zedda, M. Bardelli, F. Buricchi, G. Volpini, S. Tavarini, O. Finco, G. Del Giudice, F. Castellino;
Siena, Italy
550
P6.09.35 - Immunological characterization of M13 phage vaccine
Kazuhisa Sugimura, T. Osako, S. Kawabata, R. Miyahara, T. Tsurumaru, R. Oda, D. Tomari, R. Shioya, S. Hashiguchi;
Kagoshima, Japan
551
P6.09.36 - New proteoliposomevaccineformulation from N. meningitidisserogroup B, without aluminum hydroxide,
retains its antimeningococcalprotectogenic potential as well as Th-1 adjuvant capacity
Beatriz Tamargo;
Habana, Cuba
552
P6.09.37 - Evaluation of the Adjuvant properties for Chitosan-Polyvinylpyrrolidone-based Nanoparticles
I.Y. Izaguirre-Hernández, A.Y. Tenorio-Barajas, V.M. Altuzar-Aguilar, C.O. Mendoza-Barrera, Hector Vivanco-Cid;
Veracruz, Veracruz, Mexico
553
P6.09.38 - A Non-lytic form of Listeriolysin O induces Human Dendritic Cells to produce IL-12 and IL-23
K. Hernandez-Flores, P. Thomas-Dupont, F. Mijangos-Zamudio, Y. Paterson, Hector Vivanco-Cid;
Veracruz, Veracruz, Mexico
554
P6.09.39 - Adjuvant-induced muscle ATP release potentiates response to vaccination
Maria Vono, M. Taccone, P. Caccin, M. Gallotta, M. Pallaoro, R. Rappuoli, E. De Gregorio, F. Di Virgilio, C. Montecucco, A. Seubert;
Padova, Italy
555
P6.09.40 - Effect of monogalactosyldiacylglycerol from different marine macrophytes on conformation
and immunogenicity of hemagglutinin of Influenza A virus H1/N1 A/California/07/2009
Vladimir N. Vorontsov, N.M. Sanina, E.Y. Kostetsky, A.V. Tsybulsky, L.A. Davydova, A.N. Mazeika, N.S. Vorobieva, V.L. Shnyrov;
Vladivostok, Russian Federation
556
P6.09.41 - Cyclic-di-GMP based immune stimulatory formulations as novel vaccine adjuvants and anti-cancer agents
Soner Yildiz, E. Alpdundar, B. Bayyurt, M. Ozcan, G. Gucluler, D. Bayik, B. Gungor, I. Gursel, M. Gursel;
Ankara, Turkey
226
Posters - August 26
P6.10 MUCOSAL VACCINES
Session Time: Monday, August 26, 13:20 - 15:00
557
P6.10.01 - Determinants of immune responses to mucosal delivery of a malaria parasite protein on Lactococcus lactis cell walls
and co-administration of an inducer strain
Sivagowry Anavarathavinayagamoorthy, R. Ramasamy;
Colombo, Sri Lanka
558
P6.10.02 - Mucosal delivery of ACNPV baculovirus driving expression of the Gal-lectin LC3 fragment confers protection
against amoebic liver abscess in hamster
Julio C. Carrero, D.M. Meneses-Ruiz, J.H. Aguilar-Diaz, J. Hernandez-Ruiz, A. Luz-Madrigal, L. Vaca, J.P. Laclette;
Ciudad de México, Mexico
559
P6.10.03 - Mucosal influenza vaccine comprising of M2e-HSP70 formulated with N-Trimethyl chitosan(TMC) particles
induces strong M2e specific immune responses
Mehran Dabaghian, S. Ebrahimi, M. Tebianian, G. Nikbakht Brujeni;
Tehran, Iran, Islamic Republic of
560
P6.10.04 - Beta-glucan particles as novel antigen delivery systems: towards oral vaccination
Rebecca De Smet, S. Verschuere, T. Demoor, L. Allais, M. Dierendonck, B.G. De Geest, C. Pilette, C. Cuvelier;
Ghent, Belgium
561
P6.10.05 - Hsp65-producing Lactococcus lactis prevents experimental colitis by IL-10- and TLR2-dependent pathways
Ana M.C. Faria;
Belo Horizonte, Brazil
562
P6.10.06 - Prime-boost strategies in mucosal immunization affect local IgA production and the type of Th response
Fabio Fiorino, E. Pettini, G. Pozzi, D. Medaglini, A. Ciabattini;
Siena, Italy
563
P6.10.07 - Nanogel-based PspA nasal vaccine induces S. pneumoniae -specific neutralizing antibody immune responses in
nonhuman primates
Yoshiko Fukuyama, Y. Yuki, Y. Katakai, H. Takahashi, S. Sawada, H. Shibata, M. Mejima, S. Kurokawa, K. Akiyoshi, H. Kiyono;
Tokyo, Japan
564
P6.10.08 - Immunisation using a sustained release vaccine generates functional CD8 T cell memory
Andrew J. Highton, S. Hook, R. Kemp;
Dunedin, New Zealand
565
P6.10.09 - In vitro Inhibition of Staphylococcus aureus Isolates by Anti-Anti-Idiotypic Antibodies to Staphylococcal Protein
A (SpA)
Angel A. Justiz Vaillant, P. Akpaka, M. Smikle, N. McFarlane-Anderson;
Saint Augustine, Trinidad and Tobago
566
P6.10.10 - Nanogel-based pneumococcal surface protein A (PspA) intranasal vaccine prevents invasive disease and nasal
colonization by pneumococcus
Ilgyu Kong, A. Sato, Y. Yuki, T. Nochi, H. Takahashi, S. Sawada, M. Mejima, K. Okada, K. Akiyoshi, H. Kiyono;
Tokyo, Japan
567
P6.10.11 - The protective activity of the bacterial antigens in mucosal route of immunization in mice
Olga V. Lebedinskaya, N.P. Utkina, N.K. Akhmatova;
Perm, Russian Federation
568
P6.10.13 - T-cell priming characterisation through a systems biology approach
E. Pettini, Gennaro Prota, A. Ciabattini, A. Boianelli, F. Fiorino, G. Pozzi, A. Vicino, D. Medaglini;
Siena, Italy
569
P6.10.15 - Encapsulation of antigens in whole plant cells functions as a combined production and delivery platform for oral
vaccines
Robert P. Shepherd, A.M. Walmsley;
Clayton, Australia
570
P6.10.16 - Establishment of murine norovirus S7 infection system for vaccine development
Natsumi Takeyama, Y. Chen, Y. Tohya, K. Oroku, H. Kiyono, Y. Yuki;
Ome, Tokyo, Japan
571
P6.10.17 - Maternal antibodies enhance systemic and local immune responses after early mucosal immunization in a porcine
model
Marco A. Vega-Lopez, E.R. Guzman-Bautista, C.E. Garcia-Ruiz, A.L. Gama, C. Ramirez-Estudillo, O.I. Rojas;
Mexico, D.F., Mexico
572
P6.10.18 - M-cell targeting strategy improved the immunogenicity of viral myocarditis-specific mucosal DNA vaccine
Yan Yue, S. Xiong, W. Xu;
Suzhou, Jiangsu Province, China
P7.05 EVOLUTION OF THE IMMUNE SYSTEM AND COMPARATIVE IMMUNOLOGY
Session Time: Monday, August 26, 13:20 - 15:00
573
P7.05.01 - Innate immunity of the Mytilus galloprovincialis mussel and environmental pollution: Study of some parameters
and interactions
Younes Bouallagui, R. Ben Younes, R. Oueslati;
Bizerta, Tunisia
227
Posters - August 26
574
P7.05.02 - The role of bidirectional activity of NWC promoter in the evolution of RAG transposon
L. Sniezewski, A. Laszkiewicz, L. Bzdzion, M. Kasztura, S. Walach, P. Kisielow, Malgorzata Cebrat;
Wroclaw, Poland
575
P7.05.03 - Amyloidogenesis as protective response in invertebrates and vertebrates
Magda de Eguileor, R. Girardello, A. Grimaldi, D. Malagoli, L. Pulze, G. Tettamanti, E. Ottaviani, R. Valvassori;
Varese, Italy
576
P7.05.04 - Innate immunity and evolution of antioxidant defenses: the methionine sulfoxide reductase genes in the ciliated
protozoan Tetrahymena thermophila
Diana Ferro, F. Cattalini, O. Coppellotti, R. Bakiu, E. Piccinni, G. Santovito;
Padova, Italy
577
P7.05.05 - Evolution of the complement system: ancient molecules and new evidences from tunicates
Nicola Franchi, L. Ballarin, N. Parrinello;
Palermo, Italy
578
P7.05.07 - Characterization of the IL-17 and IL-17 receptor families in lampreys
Qifeng Han, M. Hirano, M. Cooper;
Atlanta, United States
579
P7.05.08 - Genomic analysis in inbred mice provides insights into the evolutionary history of NKG2D ligand genes
Mizuho Kondo, J. Kasamatsu, Y. Sarada, N. Otsuka, T. Takada, A. Toyoda, A. Fujiyama, T. Shiroishi, M. Kasahara;
Sapporo, Japan
580
P7.05.09 - Cranial base (CB)/brain and immune system of the fetus and neonate in concert in evolutionary development
Alexandra Kunz, C. Iliadis;
Boston, United States
581
P7.05.10 - A Research Coordination Network in Ecological Immunology
Lynn B. Martin, D.M. Hawley, D.R. Ardia;
Tampa, United States
582
P7.05.11 - Functional analyses of lymphocytes and granulocytes isolated from the thymus, spiral valve intestine, spleen,
and kidney of juvenile Australian lungfish, Neoceratodus forsteri
Mohammad G. Mohammad, M.H. Golakani, J. Joss;
Sydney, Australia
583
P7.05.12 - The introduction of monoclonal antibody Institute: the region’s largest student center
Mohammad Naghavi - Behzad, M. Ghojazadeh, A. Naghavi-Behzad, R. Piri;
Tabriz, Iran, Islamic Republic of
584
P7.05.13 - The cattle germline IGHV repertoire is very limited
Mikael Niku, J. Liljavirta, K. Durkin, E. Schroderus, A. Iivanainen;
Helsinki, Finland
585
P7.05.14 - Risk Factors Associated with the Acquisition of HIV/STIs in Female Sex Workers (FSWs) in Lagos Nigeria
Ngozi M. Otuonye, O. Enabulele Onmoiwu, H. Aliyu, C. Onwuamah;
Yaba, Lagos, Nigeria
586
P7.05.15 - Boosting heterosubtypic neutralization antibodies in recipients of the 2009 pandemic H1N1 influenza vaccine
Chao Qiu, Y. Huang, Y. Hu, Z. Yuan, X. Zhang, J. Xu;
Shanghai, China
587
P7.05.16 - R4 regulators of G-protein signaling share a common ancestry with the MHC paralogons
Jaanus Suurväli, J. Robert, P. Boudinot, S. Rüütel Boudinot;
Tallinn, Estonia
588
P7.05.17 - Comparative study on primary structure and function of rhesus monkey and human granulocyte-macrophage
colony stimulating factor
Ze Tao, H. Yang, D. Jia, L. Wan, J. Cheng, X. Lu;
Chengdu, Sichuan, China
589
P7.05.18 - The Drosophila immune response to Invertebrate Iridescent Virus 6
Cara C. West, W. Theurkauf, N. Silverman;
Worcester, United States
P7.07 VETERINARY IMMUNOLOGY
Session Time: Monday, August 26, 13:20 - 15:00
590
P7.07.02 - Tumoral necrosis factor alpha (TNF-alpha) and interleukine 1 alpha (IL-1 alpha) expression in intestinal mucosa of
young alpacas (vicugna pacos) with histological diagnostic of necrotic enteritis
Carla Bardález, A. Manchego, K. Chiok, N. Sandoval, J. More, M. Ramírez, H. Rivera;
Lima, Peru
591
P7.07.03 - Dynamics of T and B cells in lymphoid organs during the experimental infection of specific-pathogen free (SPF)
layers with Fowl adenovirus (FAdV) serotype 4
Ivan Best, W. Medina, E. Choque, M. Fernández-Sánchez, M. Fernández-Díaz;
Chincha, Peru
592
P7.07.04 - Immunological assessment of Aleuria Aurantia Lectin
Gesa M. Bindke, F. Roth-Walter, J. Singer, K. Jaeger, R. Brunthaler, K. Köhler, A. Willensdorfer, E. Jensen-Jarolim;
Vienna, Austria
228
Posters - August 26
593
P7.07.05 - Immunodiagnosis of porcine cysticercosis: Identification of accurate antigens through immunoproteomics
Raúl J. Bobes, Y. Diaz Masmela, G. Fragoso, J. Ambrosio, G. Rosas, K.J. Estrada, J.C. Carrero, E. Sciutto, J.P. Laclette;
Mexico City, Mexico
594
P7.07.06 - Monocyte chemoattractant protein-1 polymorphisms influence T cell proliferation and T subsets
Hsiu-Luan Chang, H. Chaung, J. Yu, Y. Li, S. Liu, W. Chung;
Pingtung, Taiwan
595
P7.07.07 - Soluble FliC fusion protein cloned from Salmonella Enteritidis stimulates TLR7 and TLR8 expressions
Hso-Chi Chaung, Y. Lien, M. Wu, L. Hung, W. Chung;
Pingtung, Taiwan
596
P7.07.08 - Gentamicin-attenuated Leishmania infantum vaccine: protection of dogs against canine visceral leehmaniasis
in endemic areas of southeast of Iran
Hamid Daneshvar, M. Namazi, M. Molaie, H. Kamiabi, S. Phillips, R. Burchmore;
Kerman, Iran, Islamic Republic of
597
P7.07.09 - Bm86 and Hd86 anti-Hyalomma scupense tick vaccine trials in cattle, efficacy and limits
Yousr Galaï, M. Ben Saïd, M. Gharbi, M. Jedidi, J. de la Fuente, M. Darghouth;
Belvedere Tunis, Tunisia
598
P7.07.10 - Evaluation of vaccines against foot and mouth disease in the mouse model, correlation with efficacy in cattle
Victoria Gnazzo, E. Pereyra, V. Quattrocchi, I. Soria, C. Langellotti, C. Mongini, V. Lopez, E. Smitsaart, P. Zamorano;
Capital Federal, Argentina
599
P7.07.11 - Producing Anti-Somatostatin-14 in Eggs of Immunized Chickens and Evaluating Antibody by ELISA
Fariba Golchinfar, R. Madani;
Karaj, Iran, Islamic Republic of
600
P7.07.12 - Development of monoclonal antibodies against (PPR) virus
Fariba Golchinfar, R. Madani, T. Emami;
Karaj, Iran, Islamic Republic of
601
P7.07.13 - Participation of Treg cells in equine Recurrent Airway Obstruction
Claudio Henriquez, G. Morán, B. Perez, N. Morales, H. Folch;
Valdivia, Chile
602
P7.07.14 - Emetic potential of newly identified staphylococcal superantigens
Ken’ichi Imanishi, K. Omoe, H.K. Ono, H. Kato, K. Shinagawa, J. Yagi, A. Nakane, T. Uchiyama, D. Hu;
Tokyo, Japan
603
P7.07.15 - The technique for large-scale production of CpG DNA adjuvant and applications in avian vaccines
H. Chaung, L. Hung, Y. Tsai, Yi-Yang Lien;
Pingtung, Taiwan
604
P7.07.16 - Development of an ELISA for determination of potency in snake anti venoms
Rasool Madani, F. Golchinfar, T. Emami;
Karaj, Iran, Islamic Republic of
605
P7.07.17 - Determination of lymphocytes subpopulations in peripheral blood cells of dogs with atopic dermatitis
Alicja Majewska, K. Dembele, M. Gajewska, T. Motyl;
Warsaw, Poland
606
P7.07.18 - Human anti-langerin (CD207) polyclonal antibodies detect epidermal Langerhans-like cells
in the sea turtle (Chelonia mydas)
Fernando A. Muñoz, J. Calderon-Amador, A. Negrete-Philippe, L. Flores-Romo;
San Luis Potosí, Mexico
607
P7.07.19 - Isolation and characterization of recombinant single chain fragment variable antibodies against Toxoplasma
gondii surface antigen
Mohadese Nakhaei Moghadam, M. Golchin;
Kerman, Iran, Islamic Republic of
608
P7.07.20 - Failures of immunization in animals with reference to the West Africa sub-region
Moses O. Odugbo;
Vom, Nigeria
609
P7.07.21 - Polyspecific antigen binding by bovine immunoglobulin heavy- and light-chain variable domains
Yfke Pasman, A.K. Kaushik;
Guelph, Canada
610
P7.07.22 - Pathogenesis of pancytopenia in canine visceral leishmaniasis: bone marrow morphological alterations
and IGF-I and IL-7 mRNA expressions
Flaviane A. Pinho, S.I. Miyashiro, L.S. Silva, E.M. Ramos-Sanchez, F.A.L. Costa, H. Goto;
São Paulo, Brazil
611
P7.07.23 - Booster BCG vaccination modulates response against Mycobacterium bovis-PPD in dairy herds with tuberculosis
Elsa Ramírez, C. Estrada, A. Ruiz, H. Esquivel, L. Higareda, G. López, L. Bojórquez;
Guadalajara, Mexico
612
P7.07.24 - Improvement in bovine haemorrhagic septicaemia vaccine potency and efficacy by aluminium nanoparticles
and keyhole limpet hemocyanin, and an approach to develop a DIVA strategy
Susim M. Ray;
Hisar,Haryana, India
229
Posters - August 26
613
P7.07.25 - TIR8/SIGIRR is expressed in tissues of adult and embryo chicken
Federica Riva, G. Manarolla, L. Turin;
Milan, Italy
614
P7.07.26 - Infection and immunity during leptospirosis disease in Golden Syrian Hamster: approaching for vaccine
biological models
Luis Alfredo Rosario Fernandez;
Havana, Cuba
615
P7.07.28 - Ocular infectious bronchitis virus vaccination induces different immune responses in the mucosal and systemic
immune compartment
Frederik W. van Ginkel, R.S. Gurjar, N. Orr, S.L. Gulley;
Auburn, United States
616
P7.07.29 - Expression of TNF-alpha mRNA in canine mammary tumors as a potential marker for tumor evolution
T.L.L. Castanheira, E. Garrido, F.S. Fernando, M.C. Rosolem, H.J. Montassier, Rosemeri O. Vasconcelos;
Jaboticabal, Brazil
617
P7.07.30 - Novel dendrimeric peptide: Immune response and protection against Foot and Mouth Disease Virus (FMDV)
induced by synthetic peptides in cattle
I. Soria, V. Quattrocchi, C. Langellotti, S. Digiacomo, D. Buscafusco, B. Garcia de la Torre, D. Andreu, F. Sobrino, E. Blanco,
Patricia Zamorano;
Buenos Aires, Argentina
618
P7.07.31 - Establishment and characterization of monoclonal antibodies against tumor-associated antigen(s)in Mc29
virus-transformed chicken hepatoma cells
Tanya Zhivkova, R. Alexandrova;
Sofia, Bulgaria
619
P7.07.32 - Expression of the novel antigen receptor (IgNAR) in the bamboo shark and isolation of antigen-specific IgNAR
domains from shark antibody repertoires
Stefan Zielonka, M. Empting, P. Ockelmann, M. Lierz, H. Kolmar;
Darmstadt, Germany
230
Posters - August 27
Panel N°
P1.03 NK CELLS AND NK RECEPTORS
Session Time: Tuesday, August 27, 13:20 - 15:00
001
P1.03.01 - Sp1 transcription factor is involved in the regulation of NKG2D ligands in tumor cells and during tumor Progression
Andrea Acebes Huerta, L. Huergo Zapico, A. Lopez Soto, A. Fernandez Guizán, M. Villa Álvarez, S. González Rodríguez;
Gijón, Spain
002
P1.03.02 - A novel immunological approach to prevent HCV recurrence in liver transplantation
Ester Badami, P. Pizzillo, D. Galvagno, M. Spada, B. Gridelli, P. Conaldi;
Palermo, Italy
003
P1.03.03 - D56+ cells in demyelinating polyneuropathies
Irina P. Balmasova, O.L. Timchenko, R.I. Sepiashvili, N.D. Yushchuk;
Moscow, Russian Federation
004
P1.03.04 - Assessment of natural killer receptors and activity in severe and moderate Chronic Fatigue Syndrome
S.L. Hardcastle, Ekua W. Brenu, D. Staines, S. Marshall-Gradisnik;
Gold Coast, Australia
005
P1.03.05 - Host response to murine CMV in class I MHC disparate mice reveals primacy of licensed NK cells in viral control
Michael G. Brown, J. Prince, A. Lundgren, M.D. Stadnisky, S.D. Turner, W.T. Nash, A. Beeber;
Charlottesville, United States
006
P1.03.06 - ADAM10 contributes to MICA/B shedding from multiple myeloma cells in response to genotoxic stress
Francesca Cecere, A. Zingoni, R. Molfetta, A. Soriani, C. Fionda, M.T. Petrucci, M.R. Ricciardi, R. Paolini, M. Cippitelli, A. Santoni;
Rome, Italy
007
P1.03.07 - Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors
J. Ni, Mathias Miller, A. Cerwenka;
Heidelberg, Germany
008
P1.03.08 - N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory
functions of human NK cells through FDPS modulation
Elena Ciaglia, S. Pisanti, P. Picardi, C. Laezza, A. Malfitano, A. D’Alessando, P. Gazzerro, E. Carbone, M. Bifulco;
Fisciano, Italy
009
P1.03.09 - NK cells in dasatinib-treated chronic myeloid leukemia patients are terminally differentiated effector cells
lacking homing and KIR receptors
Beatriz Colom-Fernandez, A. Kreutzman, B. Maestro Gutiérrez, V. López Huete, V. García-Gutiérrez, J. Steegmann, C. Muñoz Calleja;
Madrid, Spain
010
P1.03.10 - Induction of functional NK receptors on peripheral blood CD8+ T cells
Margareta Correia, M. Miller, A. Stojanovic, A. Cerwenka;
Heidelberg, Germany
011
P1.03.11 - Receptors of NK cells and lymphocytes subsets in patients stage II and III breast cancer
L.J. Najar Acosta, A. Daneri Navarro, G. Ramirez Rosales, R.A. Franco Topete, A. Oceguera Villanueva, J.M. Castro Cervantes,
E. Salas Gonzalez, J.C. Canton Romero, A. Quintero Ramos, Alicia del Toro Arreola;
Guadalajara, Mexico
012
P1.03.12 - An approach to the immunophenotypic signature of selected CD4+NKG2D+ T cell subsets
M. Garcia-Chagollan, M. Bueno-Topete, L. Jave-Suarez, S. Fujimura-Hernandez, A. Cid-Arregui, A. Aguilar-Lemarroy,
Susana del Toro-Arreola;
Guadalajara, Mexico
013
P1.03.13 - HMPV infection, immune evasion and its elimination
Mohammad Diab, A. Vitenshtein, O. Mandelboim;
Jerusalem, Israel
014
P1.03.14 - Neuroblastoma-derived transforming growth factor (TGF) β1 modulates the chemokine receptor repertoire
of human resting Natural Killer Cells
Alessandra Dondero, F. Bellora, L. Moretta, A. Castellano, F. Locatelli, M.V. Corrias, A. Moretta, C. Bottino, R. Castriconi;
Genova, Italy
015
P1.03.15 - Related Human Cytomegalovirus Genes US18 and US20 Target MICA for Lysosomal Degradation
Ceri A. Fielding, V. Prodhomme, R. Aicheler, S. Seirafian, J. Davies, R. Stanton, A. Davison, P. Lehner, P. Tomasec, G. Wilkinson;
Cardiff, United Kingdom
016
P1.03.16 - Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation
and function
Jessica Filtjens, S. Taveirne, A. Van Acker, E. Van Ammel, M. Van Hees, T. Kerre, T. Taghon, B. Vandekerckhove, J. Plum, G. Leclercq;
Ghent, Belgium
017
P1.03.17 - Inhibition of Glycogen Synthase Kinase-3 increases NKG2D Ligand MICA expression and sensitivity
to NK cell-mediated cytotoxicity in Multiple Myeloma cells: role of STAT3
Cinzia Fionda, G. Malgarini, A. Soriani, A. Zingoni, F. Cecere, M. Iannitto, M. Ricciardi, M. Petrucci, A. Santoni, M. Cippitelli;
Rome, Italy
018
P1.03.18 - Do NK cells play a role in the possible association between natalizumab treatment and the development
of melanoma?
Ilaria Gandoglia, A. Laroni, P. Carrega, G.L. Mancardi, G. Ferlazzo, A. Uccelli;
Genoa, Italy
231
Posters - August 27
019
P1.03.19 - Elucidating the role of the natural killer cell receptor, Ncr1, in controlling melanoma metastases using in vivo
reflectance confocal microscopy
Ariella Glasner, A. Levi, J. Enk, T. Neuman, C.D. Enk, O. Mandelboim;
Jerusalem, Israel
020
P1.03.20 - The receptor KIR3DS1 expressed by NK cell is associated with HCV viral clearance
Rafael Gonzalez, A. Rivero-Juarez, B. Manzanares, Á. Camacho, M. Frías, A. Martínez, L. Castro, A. Rivero, J. Peña;
Córdoba, Spain
021
P1.03.21 - Measurement of natural killer cell apoptotic inducing lytic proteins in peripheral blood mononuclear cells
and isolated natural killer cells
Teilah K. Huth, E.W. Brenu, K.J. Ashton, D. Staines, S.M. Marshall-Gradisnik;
Gold Coast, Australia
022
P1.03.22 - Functional NK cells developed from human hematopoietic stem cell in human interleukin-2 transgenic NOG mice
Ikumi Katano, R. Ito, T. Takahashi, M. Ito;
Kawasaki, Japan
023
P1.03.23 - Multi-step defect in NK cells and acute myeloid leukemia interaction
Zena Khaznadar, N. Setterblad, G. Henry, S. Agaugue, E. Raffoux, N. Boissel, H. Dombret, A. Toubert, N. Dulphy;
Paris, France
024
P1.03.24 - Differential requirements of activating and inhibitory Ly49 receptors in recognition of MCMV-infected cells
M. Babic-Cac, V. Juranic-Lisnic, M. Pyzik, B. Popovic, S.M. Vidal, S. Jonjic, Astrid Krmpotic;
Rijeka, Croatia
025
P1.03.25 - Spinal Cord Injury-induced Immune Depression Syndrome - the role of NK and T cells
Inês Laginha;
Berlin, Germany
026
P1.03.26 - Cytomegalovirus regulation of mouse PVR
Tihana Lenac Rovic , N. Stanietsky, S. Jordan, V. Juranic Lisnic , A. Tomic, M. Babic, A. Krmpotic, P. Tsukerman, O. Mandelboim,
S. Jonjic ;
Rijeka, Croatia
027
P1.03.27 - Regulatory roles of novel NK-like CD56brightCD11c+ cells on expansion of γδ T cells and memory CD8+ T cells
Wen Li, H. Yammamoto, K. Yamanishi, H. Yamanishi, H. Okamura;
Nishinomiya, Japan
028
P1.03.28 - Structure of the human activating receptor NKp65 bound to its keratinocyte ligand KACL (CLEC2A) reveals basis
for genetically linked recognition in the natural killer gene complex
Yili Li, Q. Wang, S. Chen, P.H. Brown, R.A. Mariuzza;
Rockville, United States
029
P1.03.29 - Crosstalk between Dendritic Cells and NK cells in the Immune Response against the dimorphic fungus
Paracoccidioides brasiliensis
Larissa N.A. Longhi, M.C. Ferreira, M.H.S.L. Blotta, R.L. Mamoni;
Campinas, Brazil
030
P1.03.30 - Interleukin-21 promotes the differentiation of a population of natural killer lymphocytes expressing CD86
and HLA-DR with the ability to activate naive CD4 T cells
Romain Loyon, E. Picard, A. Claude, J. Pallandre, O. Adotevi, Y. Godet, C. Borg;
Besançon, France
031
P1.03.31 - NK cell reconstitution following manipulated or un-manipulated haploidentical hematopoietic stem cell
transplantation in leukemia patients
Raffaella Meazza, M. Falco, C. Tuberosa, F. Loiacono, M. Mingari, A. Moretta, A. Bacigalupo, L. Moretta, F. Locatelli, D. Pende;
Genova, Italy
032
P1.03.32 - Simultaneously expression of NKG2DL MICA/MICB and NKG2D receptor on human cervical cancer cells
J-F Mendoza-Rincon, S.B.C. Bautista-Castillo, C.M.R. Mendoza-Rodriguez;
Mexico City, Mexico
033
P1.03.33 - Characterisation of chicken NK cell receptors
El Kahina Meziane, N. Potts, T. Pizzari, D. Richardson, K. Watson, T. Goebel, J. Kaufman;
Cambridge, United Kingdom
034
P1.03.34 - Dopaminergic D5 Receptor-mediated inhibition of NK cell proliferation and production of IFN-γ
Joanna Mikulak, L. Bozzo, A. Roberto, P. Tentorio, S. Bonaldo, D. Mavilio;
Rozzano (MI), Italy
035
P1.03.35 - Helicobacter pylori increases NK cell response increasing ULBP2 surface expression in adenocarcinoma gastric
cell lines
María C. Molina, C.J. Hernández, C.H. Ribeiro, M. Garrido-Tapia, K. Kramm;
Santiago, Chile
036
P1.03.36 - Adenosine produced by a CD38-mediated pathway in CD56bright CD16- NK cells inhibits autologous CD4+T cell
proliferation
Fabio Morandi, A.L. Horenstein, A. Chillemi, G. Zaccarello, F. Malavasi, V. Pistoia;
Genoa, Italy
037
P1.03.37 - Correlation between natural killer cells functionality and response to trastuzumab treatment in HER2+ breast
cancer patients
Lapo Morelli, M. Ciranna, G. Curigliano, G. Penna, M. Rescigno;
Milan, Italy
232
Posters - August 27
038
P1.03.38 - Modulation of activatory and inhibitory receptors of NK cells by CD137 costimulation
Shadi Navabi, N.H.J.H. Doroudchi, M;
Shiraz, Iran, Islamic Republic of
039
P1.03.39 - Natural killer cells in upper respiratory airway
Kazunari Okada, S. Sato, A. Sato, Y. Inoue, T. Yabe, H. Kiyono;
Tokyo, Japan
040
P1.03.40 - Expression of Ly6C defines two subsets of mature mouse NK cells
Ai Omi, T. Kiniwa, Y. Enomoto, A. Miyajima;
Bunkyo-ku, Tokyo, Japan
041
P1.03.41 - Cervical cancer cells treated with EGCG inhibitor induces changes in IFN-gamma, TNF-alpha
and perforin secretion in NK-92 cells
Pablo C. Ortiz-Lazareno, A. Bravo-Cuellar, P. Gomez-Lomeli, G. Hernandez-Flores, J.R. Dominguez-Rodriguez, L.F. Jave-Suarez,
A. Aguilar-Lemarroy;
Guadalajara, Mexico
042
P1.03.42 - Multidisciplinary approaches to enhance BRAF targeted therapy in Melanoma
Pradeepa Narayana Pangigadde, T. Tan, S. Ferrone, K. Karre, F. Colucci, E. Carbone;
Stockholm, Sweden
043
P1.03.43 - KIR2DS1-dependent acquisition of CCR7 and migratory properties by human NK cells interacting
with allogeneic HLA-C2+ DC or T cell blasts
SIlvia Pesce, S. Sivori, S. Carlomagno, L. Moretta, A. Moretta, E. Marcenaro;
Genova, Italy
044
P1.03.44 - Regulation of NKG2D and DNAM-1 ligand expression in HCMV infected fibroblasts: role of the DNA damage
response pathway and of viral replication
Benedetta Pignoloni, V. Dell’Oste, G. Gribaudo, M. Cippitelli, G. Malgarini, C. Fionda, A. Zingoni, S. Landolfo, A. Santoni, C. Cerboni;
Rome, Italy
045
P1.03.45 - Deletion of IL-33 receptor reduces NK cell and CD8 T cell responses to herpesvirus infection
Branka Popovic, M. Milovanovic, A. Krmpotic, M. Lukic, S. Jonjic;
Rijeka, Croatia
046
P1.03.46 - Down-regulation of the NKG2D receptor is differentially controlled by MICA and ULBP2 ligands
Linda Quatrini, R. Molfetta, F. Gasparrini, C. Capuano, A. Zingoni, R. Galandrini, A. Santoni, R. Paolini;
Rome, Italy
047
P1.03.47 - Expression of ligands for NK cell receptors NKG2D and DNAM-1 on drug-induced senescent Multiple Myeloma cells
depends on redox signaling
Biancamaria Ricci, A. Soriani, M. Iannitto, C. Fionda, M. Cippitelli, S. Morrone, M. Petrucci, M. Ricciardi, A. Santoni;
Rome, Italy
048
P1.03.48 - Tumour-Priming of Natural Killer Cells
May S. Sabry, M.W. Lowdell;
London, United Kingdom
049
P1.03.49 - Association of activating kir genes with the late-onset crohn’s disease
Suzanne Samarani, D. Mack, C. Bernstain, C. Deslandres, C. Faure, D. Amre, A. Ahmad;
Montreal, Canada
050
P1.03.50 - In vitro culture with IL-15 increases NK cell degranulation and enhances NK cell-mediated dendritic cell maturation
B. Sanchez-Correa, J.M. Bergua, C. Campos, M.J. Arcos, H. Bañas, S. Morgado, S. Sanchez Mateos, J.J. Gordillo, J.G. Casado,
Raquel Tarazona;
Caceres, Spain
051
P1.03.51 - Immunosuppressed pre-metastatic niches are caused by hypoxic tumour-derived factors
Jaclyn Sceneay, M.T. Chow, D.D.L. Bowtell, M.J. Smyth, A. Moeller;
Melbourne, Australia
052
P1.03.52 - Characterization of activated and expanded natural killer cells for the use in cancer therapy
M. Granzin, S. Müller, B. Gerstmayer, S. Tomiuk, A. Jacobs, B. Wollscheid, V. Huppert, Jürgen Schmitz;
Bergisch Gladbach, Germany
053
P1.03.53 - Conserved cellular miRNA-viral mRNA interactions in influenza A/H1N1: a bioinformatical approach
Einat Seidel, M. Seidel, O. Mandelboim;
Jerusalem, Israel
054
P1.03.54 - Improvement of NK cells functional activation after long-term IL-2 stimulation in vitro from ovarian neoplasia
patients
Rodrigo F. Silva;
Campinas, Brazil
055
P1.03.55 - Role of HLA-I molecules on NK cells’ phenotype and functions
Marwan C. Sleiman, N. Brons, T. Kaoma, F. Bernardin, J. Zimmer;
Luxembourg, Luxembourg
056
P1.03.56 - Impairment of natural killer cell function in HIV-1 infected individuals from Brazil
Luana S. Soares, M.S. Espíndola, L.J.G. Lima, M.C. Cacemiro, C. Fontanari, L.H. Faccioli, S.K. Haddad, V.R. Bolela, F.G. Frantz;
Ribeirao Preto, Brazil
057
P1.03.57 - Influence of age and pro-inflammatory state on the frequency of NK cells subpopulations
C. Campos, A. Pera, B. Sanchez-Correa, S. Morgado, I. López, C. Alonso, R. Tarazona, Rafael Solana;
Cordoba, Spain
233
Posters - August 27
058
P1.03.58 - NKG2D ligand expression in glomeruli correlates with renal NK cell infiltration in the MRL mouse model
Roberto Spada, S. Perez, D.F. Barber;
Madrid, Spain
059
P1.03.59 - Phenotypic and functional characterization of the CD56dimCD16lowNK cell subset in bone marrow
and peripheral blood of healthy donors
Helena Stabile, S. Morrone, D. Pagliara, F. Locatelli, A. Santoni, A. Gismondi;
Rome, Italy
060
P1.03.60 - CD28 and CTLA-4 are expressed by mouse NK cells and differentially control NK cell IFN-γ production in response to
mature dendritic cells
Ana Stojanovic, N. Fiegler, M. Brunner-Weinzierl, A. Cerwenka;
Heidelberg, Germany
061
P1.03.61 - CRACC-CRACC interaction enhances NK cell-mediated liver injury via Kupffer cells
Rui Sun, Y. Li, Z. Tian;
Hefei, China
062
P1.03.62 - Immunoregulatory effects of Natural Killer cells in Multiple Sclerosis
Ilhan Tahrali, U. Kucuksezer, E. Aktas Cetin, N. Okumus Akdeniz, A. Yilmaz, U. Uygunoglu, A. Altintas, G. Deniz;
Istanbul, Turkey
063
P1.03.63 - NK cell degranulation against human melanoma cell lines is correlated with the expression of NKG2D ligands
S. Morgado, B. Sanchez-Correa, J.G. Casado, F. Sierra, E. Durán, S. Sanchez Mateos, J.J. Gordillo, A. Pera, R. Solana, Raquel Tarazona;
Caceres, Spain
064
P1.03.64 - Phenotypic Evaluation of NK and NKT-like cells in peptic ulcer and gastric adenocarcinoma caused
by Helicobacter pylori infection
Mohsen Tehrani, A. Ajami, M. Shadman, A. Rafiei, H. Hussein-Nattaj, V. Hosseini, T. Taghvaei, H. Mesali, H. Asgarian;
Sari, Iran, Islamic Republic of
065
P1.03.65 - Fluorescent tagged NK cell receptors expressed in vivo using retrogenic mice to study the delivery of signals
in NK cells
David Tomaz, N. Guerra, J. Dyson, K. Gould;
London, United Kingdom
066
P1.03.66 - MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition
by natural killer cells
Pinchas Tsukerman, O. Mandelboim;
Jerusalem, Israel
067
P1.03.67 - Phenotypic and functional assays based on NK cells to address the diagnosis of X-linked lymphoproliferative disease 1
Claudia Tuberosa, R. Meazza, M. Falco, V. Cetica, C. Bottino, M. Aricò, M. Mingari, A. Moretta, L. Moretta, D. Pende;
Genoa, Italy
068
P1.03.69 - The human cytomegalovirus induces the CEACAM1 expression to escape immune elimination
Alon Vitenshtein, O. Mandelboim;
Jerusalem, Israel
069
P1.03.70 - The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity through the lytic synapse formation
Toyoshi Yanagihara, Y. Sakai, Y. Tanaka, Y. Fukui;
Fukuoka city, Japan
070
P1.03.71 - Dimerization of NKp46 receptor is essential for NKp46-mediated lysis: characterization of the dimerization site
by epitope mapping
Rami Yossef, M. Jaron-Mendelson, A. Porgador;
Beer-Sheva, Israel
P1.05 INNATE LYMPHOCYTES
Session Time: Tuesday, August 27, 13:20 - 15:00
071
P1.05.01 - Role of γδ T cells in neuronal injury
Katja Derkow, C. Krüger, S. Lehnardt;
Berlin, Germany
072
P1.05.02 - IL-22 promotes bacteria-driven colon cancer
Fanny Franchini, S. Kirchberger, N. West, D.J. Royston, F.M. Powrie;
Oxford, United Kingdom
073
P1.05.03 - B1 cells provide immunosurveillance of healthy and inflamed skin
Skye A. Geherin, M.H. Lee, R.P. Wilson, G.F. Debes;
Philadelphia, United States
074
P1.05.04 - Activating receptor engagement elicits inflammatory signatures in RORγt+ innate lymphoid cells
Timor Glatzer, M. Killig, I. Ommert, M. Luetke-Eversloh, M. Babic, D. Paclik, J. Gröne, J. Meisig, K. Stölzel, C. Romagnani;
Berlin, Germany
075
P1.05.05 - The regulatory effect of IL-4 on the anti-tumor immune response mediated by human γδ T cells
Y. Mao, J. Zhang, Y. Hu, L. Cui, N. Kang, Wei He;
Beijing, China
076
P1.05.06 - Intestinal epitherial NK cells produce α-defensin, but convetional NK cells do not
Tetsuji Hori, N. Nagaoka, M. Yamamoto, M. Ando, S. Matsumoto;
Tokyo, Japan
234
Posters - August 27
077
P1.05.07 - TCRγδ signal activation is required to overcome inhibition by ubiquitin ligase Cbl-b during γδT cell cytotoxicity
S. Yin, J. Zhang, L. Cui, Y. Hu, Ning Kang, W. He;
Beijing, China
078
P1.05.08 - Innate lymphoid cells mediate IL-33 dependent fibrosis
Tamar Mchedlidze, S. Pflanz, M. Schuchmann, M. Neurath, S. Wirtz;
Erlangen, Germany
079
P1.05.09 - Morphologic, flow cytometric, functional, and molecular analyses of S100B positive lymphocytes, unique
cytotoxic lymphocytes containing S100B protein
Yukari Miki, Y. Gion, Y. Mukae, A. Hayashi, K. Takahashi;
Kagawa, Japan
080
P1.05.10 - Type I Interferon signaling in a mouse de novo glioma model
Takayuki Ohkuri, A. Ghosh, A. Kosaka, J. Zhu, M. Ikeura, S.C. Watkins, H. Okada, S.N. Sarkar;
Pittsburgh, United States
081
P1.05.11 - Insight into interaction innate immune response: Role for Asn40Asp allele of OPRM1 gene
Anuradha Pal, S. Kapur;
Hyderabad, India
082
P1.05.12 - Human B-1 cell frequency and aging from cord blood to the elderly
Ali A. Pourfathollah, M. Jazayeri;
Tehran, Iran, Islamic Republic of
083
P1.05.13 - An innate-like CD4+ T cell expressing complement receptor 1
Brian Reilly, K. Rasberry, J. Atkinson;
Lubbock, United States
084
P1.05.14 - The C-terminal region of the Activation Induced Cytidine Deaminase (AID) is required for the gene conversion
and mediates the end joining during class switch recombination
Somayeh Sabouri, M. Kobayashi, T. Honjo;
Kyoto, Japan
085
P1.05.15 - HIV infection inhibits the crosstalk between monocytes-derived dendritic cells and Vγ9 2δ cells
Alessandra Sacchi, N. Tumino, R. Casetti, A. Rinaldi, F. Turchi, F. Martini;
Rome, Italy
086
P1.05.16 - Type 2 Innate Lymphoid cells (ILC2) reside in the human skin and contribute to atopic dermatitis
Maryam Salimi, J.L. Barlow, S.P. Saunders, L. Xue, D. Gutowska-Owsiak, X. Wang, D. Johnson, S.C. Scanlon, A.N.J. McKenzie,
P.G. Fallon, G.S. Ogg;
Oxford, United Kingdom
087
P1.05.17 - The role of gamma-delta T lymphocytes in the switch of Ig isotypes in B-1 cells under the influence
of TI-2 antigens
Nadezda Snegireva, M. Gavrilova, E. Sidorova;
Moscow, Russian Federation
088
P1.05.18 - Innate protective responses of B1 cells dependent on activation-induced cytidine deaminase (AID) and interleukin-13
Natsuo Yamamoto, N. Nakazawa, S. Kerfoot, C. DelaCruz, M. Majewska-Szczepanik, M. Szczepanik, Y. Abe, N. Ohana,
K. Kanemitsu, P. Askenase;
Fukushima, Japan
P1.12 LECTINS AND GLYCOIMMUNOLOGY
Session Time: Tuesday, August 27, 13:20 - 15:00
089
P1.12.01 - The interaction of complement-activating lectins with Mycobacterium tuberculosis
Marcin A. Bartlomiejczyk, A.S. Swierzko, A. Brzostek, J. Dziadek, M. Cedzynski;
Lodz, Poland
090
P1.12.02 - Pseudo-mannosylated compounds inhibit DC-SIGN mediated HIV infection by competitive inhibition
and by interfering with DC-SIGN signal
Angela Berzi, N. Varga, P. Antonazzo, I. Cetin, M. Biasin, D. Trabattoni, A. Bernardi, M. Clerici;
Milan, Italy
091
P1.12.03 - Treatment with interferon beta-1a reduces alpha-2,3-sialylation of CD4+ helper T cells
J. Piel, K. Friebe, Felix Bischof;
Tübingen, Germany
092
P1.12.04 - Jacalin has distinct immunomodulatory effects on early and late stages of experimental colon carcinogenesis
Gabriela S. Bisson, T.H. Geraldino, P. Modiano, L.C. Veronez, R.O. Lopes, S.B. Garcia;
Ribeirão Preto, Brazil
093
P1.12.05 - The change in the glycosylation of human leukocytes in immunosuppressive environment
Katarzyna Bocian, E. Pocheć, M. Dolińska, G. Korczak-Kowalska;
Warsaw, Poland
094
P1.12.06 - Anti-Polygalacturonic acid antibodies in diagnosis and pathogenesis of rheumatoid arthritis
Hui Dai, X. Gao;
Beijing, China
095
P1.12.07 - Interaction of Siglec-7 and -9 with their ligands inhibit NK cell anti-tumor immune responses
Kayluz Frias Boligan, C. Schneider, O. Chijioke, C. Jandus, C. Münz, S. von Gunten;
Bern, Switzerland
235
Posters - August 27
096
P1.12.08 - Dectin-1 expressed on human pulmonary epithelial cells is an important pattern recognition receptor for the
detection of nontypeable Haemophilus influenzae
Kerstin A. Heyl, T.E. Klassert, B.B. Singer, A. Heinrich, M.M. Müller, R. Bals, H. Slevogt;
Jena, Germany
097
P1.12.10 - CLEC4F is a Kupffer Cells-Specific C-type Lectin Induced in F4/80-positive Cells upon Entry to Liver
Shie-Liang E. Hsieh;
Taipei, Taiwan
098
P1.12.11 - Characterization of carbohydrate preference of SIGNR1 as pathogen uptake receptor using carbohydratecoated liposomes
Yoko Kawauchi, N. Kojima;
Hiratsuka, Japan
099
P1.12.12 - The role of membrane lectins from subcellular fractions of human prostate in intracellular transformation at
different pathologies
Nino Kvitsinadze, I. Megrelishvili, R. Solomonia, E. Davitashvili;
Tbilisi, Georgia
100
P1.12.13 - The C-type lectin receptor SIGN-R3 binds to commensal microbiota and influences immune regulation
in experimental colitis
M. Eriksson, T. Johannssen, D. von Smolinski, A.D. Gruber, P.H. Seeberger, Bernd Lepenies;
Potsdam, Germany
101
P1.12.14 - Role of galectin-7 in psoriasis by regulating the skin inflammatory response through keratinocytes
Chia-Hui Lo, C. Yen, H. Chen, Y. Lo, H. Chen, F. Liu;
Taipei, Taiwan
102
P1.12.15 - R-MC 17 antigen - a rat homologue of DEC-205 antigen?
Ivana Majstorovic, D. Vucevic, V. Ilic, S. Gasic, B. Draskovic-Pavlovic, M. Colic;
Belgrade, Serbia
103
P1.12.16 - Mannose receptor plays a key role in Th1 polarization of Lactobacillus acidophilus NCFM stimulated dendritic
cells
Ronja Mathiesen, L. Henningsen, E. Fuglsang, H. Frøkiær;
Copenhagen, Denmark
104
P1.12.18 - Increased sialylation of a recombinant IgG mutant produced in human embryonic kidney 293 (HEK293) cells
Yusuke Mimura, K. Ronan, L. Unwin, S. Albrecht, Y. Mizukami, M. Goodall, T. Matsumoto, R. Jefferis, P.M. Rudd;
Ube, Japan
105
P1.12.19 - C-type lectin receptor Mincle and MCL mediate acquired immunity induced by mycobacterial glycolipid TDM
Daiki Mori, Y. Miyake, K. Toyonaga, Y. Yoshikai, S. Yamasaki;
Fukuoka, Japan
106
P1.12.20 - Anti-inflammatory drugs from bugs: Mycobacterium tuberculosis gives us a hand
E. Blattes, A. Vercellone, H. Eutamène, C. Turrin, V. Théodorou, J. Majoral, A. Caminade, J. Prandi, Jérôme Nigou, G. Puzo;
Toulouse, France
107
P1.12.21 - Galectin-3 regulates dendritic cell responses and hematopoietic cell mobilization during acute peritonitis
induced by pristane
Felipe L. Oliveira, C. Brand, D. Hsu, L. Fu-Tong, R. Borojevic, R. Chammas, M.C. El-Cheikh;
Rio de Janeiro, Brazil
108
P1.12.22 - Galectin-8 knockout mice have sex-dependent altered homeostasis of t and b lymphocytes and autoimmune
features
Evelyn Pardo, D. Valenzuela, A. Soza, A. González;
Santiago, Chile
109
P1.12.23 - The binding specificity of H. pylori LPS to DC-SIGN receptor
Karolina Rudnicka, E. Miszczyk, A. Matusiak, M. Chmiela;
Lodz, Poland
110
P1.12.24 - Galectin-3 plays a role in murine NK cell-mediated INF-γ production
E. Kim, B. Choi, J. Lee, Hee-Jong Woo;
Seoul, Korea, Republic of
111
P1.12.25 - The MBL paradox: is functional MBL deficiency may be advantageous
Tatjana Zaharov;
Odense C, Denmark
P2.07 PERIPHERAL TOLERANCE AND LYMPHOCYTE ANERGY
Session Time: Tuesday, August 27, 13:20 - 15:00
112
P2.07.01 - Anergy in CLL B lymphocytes: implications for the bio