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SCIENTIFIC PROGRAM www.ici2013.org Week-at-a-glance THURSDAY, AUGUST 22 FRIDAY, AUGUST 23 SATURDAY, AUGUST 24 SUNDAY, AUGUST 25 MONDAY, AUGUST 26 TUESDAY, AUGUST 27 Registration Registration Registration Registration Registration 07:00-08:00 08:00-08:45 Clinical Immunology Course Clinical Immunology Course Clinical Immunology Course Clinical Immunology Course Clinical Immunology Course 08:50-09:20 Perspectives in immunology Perspectives in immunology Perspectives in immunology Perspectives in immunology Perspectives in immunology Plenary Lecture Plenary Lecture Plenary Lecture NK Cells Innate Lymphocytes and Mucosal Immunity Leukocyte Signaling Genetic and Epigenetic Control Cell Trafficking Costimulatory and Inhibitory Molecules Imaging and Cell Interactions Lymphocyte Development Microbial Triggers for Inflammation Pathways in Inflammatory Diseases Therapy of Autoimmune Disease T and B Cell Repertoires Viral Infection Antigen Processing and Presentation Bacterial Infection Immunodeficiencies Autoimmune Mechanisms Cancer Immunotherapy Gene and Cell Therapy T and B cell Subsets Protozoal Fungal and Helminth Infection Parallel symposia Complement and Soluble Mediators Parallel symposia Innate Immune Sensors Parallel symposia Myeloid Cells Parallel symposia Parallel symposia 9:00-16:40 Basic Immunology Course Registration 10:20-12:25 12:30-13:15 Plenary Lecture Plenary Lecture 09:30-10:15 Immune Memory Microbiome and Microbe Adaptation Immune Surveillance and Tumor Immunity Allergy Vaccination Tolerance and Transplantation Lunch - time Lectures Lunch - time Lectures Lunch - time Lectures Lunch - time Lectures Lunch - time Lectures 13:20-15:00 Poster Discussion Poster Discussion Poster Discussion Poster Discussion Poster Discussion 13:30-15:00 Industry Symposia Industry Symposia Industry Symposia Industry Symposia 14:00-15:00 Tutorials Tutorials Tutorials Tutorials 15:10-16:40 Workshops Workshops Workshops Workshops Workshops Workshops Workshops Workshops Workshops Workshops Plenary Lecture Plenary Lecture Plenary Lecture Plenary Lecture Plenary Lecture Late Breaking Session 16:45-18:15 Opening Ceremony 18:30-19:15 Closing Ceremony 19:20-20:00 19:30-22:00 Welcome Reception Novartis Award Ceremony and Reception Faculty Dinner Else Kröner Fresenius Award Lecture PS - Perspectives in Immunology PL - Plenary Lectures S - Symposia LL - Lunchtime Lectures W - Workshops P - Posters Immunology Courses Sponsored Sessions The online abstract book is available at the Congress website www.ici2013.org Table of Contents Welcome Messages page 04 Patronages page 07 Committees page 08 Congress Venue page 10 Congress General Information page 14 Instruction for Presentation page 18 Social Program page 19 IUIS Council and Meetings page 20 Board Meetings page 21 Awards page 22 Travel Grants page 24 Immunology Courses page 26 XXIII AINI Congress page 26 Scientific Program August 22 page 27 Scientific Program August 23 page 28 Scientific Program August 24 page 38 Scientific Program August 25 page 50 Scientific Program August 26 page 60 Scientific Program August 27 page 70 Posters page 83 Sponsors and Exihibitors page 270 Speakers index page 276 Welcome Message Dear Colleagues and Friends, Why do we immunologists enjoy attending congresses so much? I guess the most frequent answers to this question include: you hear the latest news about state-of-the-art science; you get an excellent overview about what is going on in related fields; you meet friends, colleagues, young students and experienced researchers alike. For sure, this is all guaranteed at the International Congress of Immunology (ICI), which takes place every 3 years under the auspices of the International Union of Immunological Societies (IUIS). As President of the IUIS, I welcome you to join the 15th ICI to be held in Milan, Italy from August 22-27, 2013. For further information about IUIS activities, members of the Board and the Council see http://www.iuisonline.org/, and for information about our new official journal Frontiers in Immunology see http://www.frontiersin.org/immunology. The last ICI, which took place in Kobe, Japan August 2010, was a marvelous success with more than 6,000 participants. We at the IUIS are proud of the triennial ICI, which is by far the most important event in the immunology arena, globally. This was proven consistently in the past and is guaranteed at the next ICI in Milan, as assured by the outstanding researchers enlisted in the Congress Advisory Committee, the Scientific Program Committee, and other Committees. The 15th ICI promises once again to represent the full complement of one of the most vibrant scientific areas in biomedicine, immunology. It will encompass basic research, translation and clinical application. It will interest both young students and experienced researchers. It will cover the full spectrum from academic research to industry. The Congress, however, will not only serve as platform for communication and exchange of the most challenging state-of-the-art research among immunologists. It will also serve as impressive platform for making laypersons, the press and politicians aware of the importance of immunologic research for maintenance of well-being, and combat of major diseases, including infectious diseases, autoimmune diseases or allergic diseases. Last but not least, it will provide a unique platform for meeting colleagues/friends/post-doc candidates and mentors. In short, the 15th ICI will be wonderful meeting point for researchers from academia, industry and clinics both from industrialized and developing countries and hence strengthen existing friendships and invite new ones. The 15th ICI will take place in Milan, Italy and this guarantees another wonderful aspect, namely, the great opportunity for social activities in a most accessible and welcoming city. Milan boasts a unique, world famous artistic heritage, of which the best known is Leonardo da Vinci’s Last Supper. Today Milan is not only the international centre of fashion and design, but also a vibrant city, which guarantees a lot of fun after a hard working day at the Congress. The IUIS represents all immunologists worldwide, who are members of the 65 national societies and 4 regional federations of immunology. We are looking forward to meeting you all at the 15th ICI in Milan. Stefan H.E. Kaufmann President, International Union of Immunological Societies (IUIS) Max Planck Institute for Infection Biology, Berlin 4 Welcome Message Dear Colleagues and Friends, The Italian Society of Immunology, Clinical Immunology and Allergology (SIICA) is honoured to host in Milan the 15th International Congress of Immunology (ICI) from August 22 to 27, 2013. SIICA represents over 1,000 immunologists active in Italy, and several of its members are recognized as international leaders in their field, actively contributing to the development of Immunology. Therefore, the scientific organization of the ICI will count on a dedicated and competent local scientific committee, in addition to a distinguished international committee. The meeting will cover all aspects of Immunology, from the more traditional to the most innovative, with emphasis on translational aspects and clinical applications. A scientifically inspiring program will be assembled in a range of formats to cover a wide variety of interests and provide the state of the art in all different facets of Immunology. An introductory Immunology course just before the ICI, and satellite symposia at several locations in Italy will complement the scientific program. We will also offer a varied social program to provide the opportunity to meet old friends and make new ones. Milan has a rich historic heritage, dating back to its times as capital of the Western Roman Empire. Leonardo da Vinci, the quintessential Renaissance polymath artist and scientist, while in the Milan area drew his iconic Vitruvian man shown in the 15th ICI logo. Today Milan is a dynamic and trendy city, a renowned international centre of fashion and design as well as of arts and science. The City has just opened the largest and most modern congress center in Europe, which will comfortably accommodate the ICI participants. We are confident that our scientific organization, together with the well-known Italian hospitality will make the 15th ICI a memorable event. We look forward to hosting you in Milan in 2013. Luciano Adorini President 15th International Congress of Immunology 5 Patronages Under the High Patronage of the President of the Italian Republic With the Patronage of Italian Health Ministry Under the Patronage of 7 Committees Committees Honorary President Sergio Romagnani, ITA President Luciano Adorini, ITA Secretary General Massimo Locati, ITA President SIICA Vincenzo Barnaba, ITA Executive Committee Marco A. Cassatella, ITA Angela Santoni, ITA Gianpietro Semenzato, ITA Silvano Sozzani, ITA External Relations & Finance Committee Francesco Annunziato, ITA Piergiuseppe De Berardinis, ITA Armando Gabrielli, ITA Angelo Vacca, ITA Congress Advisory Committee Fernando Aiuti, ITA Jean-Francois Bach, FRA Ridha Barbouche, TUN Floriano Bonifazi, ITA Walter Canonica ITA Max Cooper, USA Antonio Coutinho, POR Günnur Deniz, TUR Peter C. Doherty, AUS C. Garrison Fathman, USA Marc Feldmann, GBR Alain Fisher, FRA Catherine Sautes-Fridman, FRA Michel Goldman, BEL Jorge Kalil, BRA Stefan H. E. Kaufmann, DEU George Kollias, GRC Carlos Martinez, ESP Masayuki Miyasaka, JAP Reinhold E. Schmidt, DEU Yehuda Shoenfeld, ISR Elopy Sibanda, ZWE Giorgio Trinchieri, USA 8 Emil Unanue, USA Dexian Zheng, CHN Moncef Zouali, FRA Scientific Program Committee Alberto Mantovani, Co-Chairman, ITA Lorenzo Moretta, Co-Chairman, ITA Abul K. Abbas, USA Shizuo Akira, JAP Jeffrey A. Bluestone, USA Olivera Finn, USA Ronald Germain, USA David Hafler, USA Leonard Harrison, AUS Marc Jenkins, USA Tadamitsu Kishimoto, JAP Antonio Lanzavecchia, SWI Foo Y. Liew, GBR Philippa Marrack, USA Diane Mathis, USA Cornelis J.M. Melief, NLD Luigi Notarangelo, USA Michael Nussenzweig, USA Anne O’Garra, GBR Andreas Radbruch, DEU Paola Ricciardi-Castagnoli, ITA Maria-Grazia Roncarolo, ITA Alexander Rudenski, USA Ethan Shevach, USA Alan Sher, USA Lawrence Steinman, USA Rolf M. Zinkernagel, SWI (Honorary) Workshop Committee Vijay Kuchroo, Co-Chairman, USA Pier Luigi Meroni, Co-Chairman, ITA Francesca Aloisi, ITA Diana Boraschi, ITA Rachel Caspi, USA Lucienne Chatenoud, FRA Edecio Cunha-Neto, BRA Anna Erdei, HUN Polly Matzinger, USA Seppo Meri, FIN Marianna N. Newkirk, CAN Fiona Powrie, GBR Luigina Romani, ITA Christopher E. Rudd, GBR Committees Hannes Stockinger, AUT Yvette van Kooyk, NLD Matthias von Herrath, USA Satellite Meetings Committee Mohamed R. Daha, Co-Chairman, NLD Carlo Pucillo, Co-Chairman, ITA Alberto Amadori, ITA Luca Battistini, ITA Francesco Dieli, ITA Leonardo Fabbri, ITA Claudio Franceschi, ITA Gianni Marone, ITA Vito Pistoia, ITA Rino Rappuoli, ITA Maria Rescigno, ITA Carlo Riccardi, ITA Mohamed R. Daha, Co-Chairman, NLD Carlo Pucillo, Co-Chairman, ITA Advisory Scientific Committee Sergio Abrignani, ITA Roberto Accolla, ITA Carlo Agostini, ITA Cezmi Akdis, SWI Sebastian Amigorena, FRA Bernd Arnold, GER Jacques Bancherau, USA Armand Bensussan, FRA Michael J. Bevan, USA Sergio Bonini, ITA Vincenzo Bronte, ITA Federico Caligaris-Cappio, ITA Silvana Canevari, ITA Mario Clerici, ITA Irun Cohen, ISR Mario Colombo, ITA Marco Colonna, USA Andrea Cossarizza, ITA Ana Cumano, FRA Mark M. Davis, USA Gennaro De Libero, SWI Michael Dustin, USA Richard Flavell, USA Jorge Gavilondo, CUB Eric Gershwin, USA Gianpiero Girolomoni, ITA Gunter Hämmerling, DEU Adrian C. Hayday, GBR Richard Hodes, USA Joachim R. Kalden, DEU Michael Karin, USA Klas Kärre, SWE Mitchell Kronenberg, USA Lewis Lanier, USA Sergio Lira, USA Dan Littman, USA Yong-Jun Liu, USA Miguel Lopez-Botet, ESP Enrico Maggi, ITA Tak W. Mak, CAN Bernard Malissen, FRA Gianvito Martino, ITA Andrew McMichael, GBR Fritz Melchers, DEU Ruslan Medzhitov, USA Alessandro Moretta, ITA Tim Mosmann, USA Kenneth Murphy, USA Frank O. Nestle, GBR Markus F. Neurath, DEU Pamela Ohashi, CAN Giorgio Parmiani, ITA Paola Parronchi, ITA William Paul, USA Hidde Ploegh, USA Klaus Rajewsky, USA Anjana Rao, USA Jeffrey Ravetch, USA Caetano Reis e Sousa, GBR Anna Rubartelli, ITA Shimon Sakaguchi, JAP Federica Sallusto, SWI Ronald Schwartz, USA Alessandro Sette, USA Josef Smolen, AUT Ludwig M. Sollid, NOR Hergen Spits, NLD Ralph Steinman, USA Andreas Strasser, AUS Nicole Suciu-Foca, USA Megan Sykes, USA Franco Tedesco, ITA Massimo Triggiani, ITA Jung Tschopp, SWI Rudolf Valenta, AUS Andrea Velardi, ITA Antonella Viola, ITA Colin Watts, GBR Hartmut Wekerle, DEU Katryn Wood, GBR Wayne Yokoyama, USA 9 Congress Venue Overview MiCo - Milano Congressi 10 Piazzale Carlo Magno, 1 Via Eginardo - GATE 2 20149 Milan, Italy POSTER AREA VB41 D33 C34 VB35 C36 VB37 C39 C40 VB39 D12 D16 C38 E13 E19 E36 E30 C30 C28 D27 VB33 VB31 VB23 VB21 VB19 D17 E20 immunology village VB29 aisle b B6 C9 C20 C22 C11 D19 E22 E16 F13 C14 D13 C12 D11 VB17 VB15 VB13 aisle b B2 C1 aisle c C16 D15 aisle d E14 aisle e E18 aisle f LUNCH BOX AREA D21 B8 VB25 C24 D23 E24 F23 C21 VB27 C26 D25 E26 F25 B16 aisle c C32 D29 aisle d D31 E28 ice cream area E32 aisle e E34 aisle f LUNCH BOX AREA F11 VB11 C10 D9 D10 E11 E12 F9 VB9 C8 D7 E10 F7 VB7 E8 VB5 D2 E1 E6 F5 VB1 bar area PARETE 3B PARETE 3A PARETE 1 INTERNET POINT CONTROVENTO 404 PAX Space 03 872 PAX Space 01+02 396 PAX LEVEL 0 Space 04 Floor Plans 11 12 LEVEL +1 LIVELLO +1 Floor Plans LEVEL +2 LEVEL Floor Plans 13 Congress General Information Congress General Information Congress Secretariat Triumph C&C Via Lucilio, 60 - 00136 Roma www.triumphgroup.it Contact details: tel. +39 06 355301 email: [email protected] Congress Venue MiCo - Milano Congressi Piazzale Carlo Magno, 1 Viale Eginardo - GATE 2 - 20149 Milan, Italy Gate Entrances Gate 2 - located in Viale Eginardo dedicated entrance for pedestrians during congress days. Gate 17 - located in Piazzale Carlo Magno dedicated entrance for pedestrians during congress days. Gate 17 - located in Piazzale Carlo Magno dedicated entrance for cars that wish to park inside the congress venue during congress days. Congress Venue Parking The underground parking entrance is located at Gate 17, Piazzale Carlo Magno. The cost for a whole day parking ticket is 15 Euros. Payment must be made directly at the exit of the parking lot. Opening hours in accordance with the congress program and event schedule. Registration Registration desk is located on Floor 1 in MiCo Congress Venue. Registration Desk Hours: Thursday, August 22 Friday, August 23 Saturday, August 24 Sunday, August 25 Monday, August 26 Tuesday, August 27 from 7.00 to 19.00 from 7.00 to 19.00 from 7.00 to 19.00 from 7.00 to 19.00 from 7.00 to 19.00 from 7.00 to 19.00 Registration Fees: Delegate registration fee includes: Access to all sessions and Exhibition Hall Congress bag and Scientific Program Opening Ceremony and Reception Closing Ceremony Categories Full FAIS Member* Students/Trainee/Resident** Basic Immunology Course Clinical Immunology Course On site € 700,00 € 300,00 € 300,00 € 100,00 € 100,00 * FAIS Member: Federation of African Immunological Societies. Official Letter required. ** Students: Graduate Students, Undergraduate Students, Ph.D. students and Ph.D. candidates. Official letter and University/Institute ID copy required. 14 Congress General Information Congress General Information Name Badges For security purposes delegates, accompanying persons and exhibitors must wear their name badge at all times in order to access MiCo congress venue and social activities. Replacement of lost badges may incur a full charge. Proceedings Congress Abstracts are available on the official website www.ici2013.org Certificate of Attendance A certificate of attendance will be downloaded on ICI2013 website www.ici2013.org from September 10. Please log back into your registration account using your username and password, in order to receive it by email. Exhibition ICI 2013 congress exhibition area is located on Floor 0 in MiCo congress venue. Exhibition of the most advanced laboratory equipments, supplies, books and journals are on display from Thursday, August 22 to Tuesday, August 27. For more information about Exhibition and Exhibitors please refer to the Sponsor section at the end of the book. Exhibition Hours Thursday, August 22 Friday, August 23 Saturday, August 24 Sunday, August 25 Monday, August 26 Tuesday, August 27 from 12.30 to 19.00 from 8.00 to 19.00 from 8.00 to 19.00 from 8.00 to 19.00 from 8.00 to 19.00 from 8.00 to 14.30 Internet Access Free wireless internet service is available following these few steps: 1) Find the Wi-Fi network using your own smart phone or tablet 2) Connect to the network using the following username and password: USERNAME: 15ICI2013 PASSWORD: 15ICI2013 3) Enjoy surfing the web! Wi-Fi available in - Exhibition Hall - Registration Area - Balcony - Corridors Wi-Fi connection will be disabled in all lecture rooms. Internet Point The internet point is located in the exhibition hall next to the poster area (floor 0). Web App To get ICI 2013 WEBAPP please follow these guidelines: 1. Open the browser of your mobile device and digit http://ici2013.jokersrl.com/ or scan the QR Code on the front page of the Scientific Program with your QR Code scanner application. 2. Save the link on your desktop and enjoy the ICI 2013 WEBAPP During the Congress days, feel free to reach the Speaker Center at level 2, where you will find technicians that will be able to assist you for any issues regarding the WEBAPP. 15 Congress General Information Congress General Information Press Office The Press Office is located in Suite 4 - Floor 2. Coffee Shops Two Coffee shops are located inside the congress venue. Bar Milano, situated in floor 2 in front of the Amber rooms and Exhibition Bar at floor 0. Opening hours August 22 from 8.00 to 17.00 August 23 to 27 from 8.00 to 19.00 Lunch Box Participants who previously purchased online the Lunch Box service, are kindly asked to collect their box at the distribution area situated at Level 0 from 12:00 to 13:15, from Friday, August 23 to Tuesday, August 27. Please provide your lunch box ticket at the lunch box distribution desk. Lunch boxes cannot be purchased onsite. All participants who have not paid for their lunch boxes online cannot benefit of the service. Luggage Cloakroom The cloakroom is located in the registration area on the right side according to the entrance. It is available only as a luggage deposit and it is free of charge for congress attendees. Opening hours in accordance with the congress program and event schedule. Language The official language of the congress is English. No simultaneous translations are available. Lost and Found Information on lost and found is available at the Info Desk at Level 1. Recording/Photo Policy It is prohibited to make audio/video recordings or to take photos. An official photographer is present for the entire event. Smoking Policy According to Italian law, smoking is prohibited in all public indoor areas, in this case including privatized areas of exhibit space. Italian Telephone Country Code Country code for Italy: +39 International outgoing code: 00 Emergency Numbers in Italy Police: 113 Carabinieri: 112 Ambulance: 118 Fire Service: 115 Roadside Assistance: 116 Taxi Taxi Milan number: 848 814 781 A taxi station is located outside the congress venue in front of Gate 2 in Viale Eginardo and in front of Gate 17 Piazzale Carlo Magno, where taxies are available mostly before and after congress hours. A taxi booking service is available at the info tourist desk. 16 Congress General Information Congress General Information Transportation MiCo Milano Congressi is easily accessible via pubblic transportation: Buses & Trams For “Viale Eginardo / Viale Scarampo” entrance: Bus No. 78 - Eginardo/Colleoni stop For “Piazzale Carlo Magno / Via Gattamelata” entrance: Bus no. 78 - get off at Colleoni/Gattamelata Tram no. 27 - get off at Piazza 6 Febbraio Metro Red Line 1: For “Viale Eginardo / Viale Scarampo” entrance: get off at “Amendola” stop - 700 m from the congress venue, or at “Lotto” approx. 800 m. For “Piazzale Carlo Magno / Via Gattamelata” entrance: get off at “Cadorna” stop, exit the subway and go to the railroad station above: take the first train departing and get off at “Domodossola” stop - just 600 m from the congress venue. Green Line 2: get off at “Cadorna”. For “Viale Eginardo / Viale Scarampo” entrance: take Red Line 1 (going to RHO Fiera Milano) and get off at “Amendola” stop - 700 m from the congress venue, or at “Lotto” approx. 800 m. For “Piazzale Carlo Magno / Via Gattamelata” entrance: exit the subway and go to the railroad station above: take the first train departing and get off at “Domodossola” stop - just 600 m from the congress venue. Yellow Line 3: get off at “Duomo”, switch to the Red Line 1 (RHO Fiera Milano direction). For “Viale Eginardo / Viale Scarampo” entrance: get off at “Amendola” stop - 700 m from the congress venue, or at “Lotto” approx. 800 m. For “Piazzale Carlo Magno / Via Gattamelata” entrance: get off at “Cadorna” stop, exit the subway and go to the railroad station above: take the first train departing and get off at “Domodossola” stop - just 600 m from the congress venue. Taxi From/to the airport to the congress venue: Linate Airport: take bus n. 73 in the National Arrival Exit area to Piazza S. Babila stop. Take the Metro Red Line 1. Get off at Amendola stop. Malpensa Airport: The Malpensa Express train service will take you directly from the airport to the center of Milan in 40 minutes, arriving at the Ferrovie Nord Cadorna Station. Here take the Metro Red Line 1. Get off at Amendola stop. Orio al Serio Airport: the bus service will take you directly from the airport to Milan Central Station in 60 mins, then take the Metro Green Line 2 (Abbiategrasso direction) and get off at Cadorna stop. Here take the Metro Red Line 1 (Rho Fiera Milano Direction). Get off at Amendola stop. 17 Instruction for Presentation Instructions for Presentation Information for Invited Speakers Allocated times for presentations in each session are as follows: Parallel Symposia: 20 mins for each presentation including questions and answers Perspectives in Immunology: 25 mins for presentation and 5 mins for questions and answers Plenary Lectures: 40 mins for presentation and 5 mins for questions and answers Lunchtimes Lectures: 40 mins for presentation and 5 mins for questions and answers Information for Invited Chairs Allocated times in each session are as follows: Workshop Chairs: 15 mins for presentation and /or session presentation Symposium Chairs: 10 mins for session presentation Information for Oral Workshop Presentations 10 mins for presentation including questions and answers. Information and Instructions for Poster Presenters Poster exhibition area and Poster Information Desk are located at Floor 0. The week schedule for the poster sessions is as follows: Friday August 23 to Tuesday August 27: Mounting Poster Display Poster session Removal 09:00-12:00 12:00-13:20 13:20-15:00 15:00-18:30 Posters can only be mounted on the day on which they have been scheduled for presentation and must be removed by the end of the same day. All remaining posters will be taken down and discarded. All poster presenters, on their presentation day, need to report to the Poster Information Desk with their poster and tape, in order to receive their poster board number. Please ensure your poster is affixed on the correct poster board. Please bring your own tape to affix your poster. Limited tape will be available at the Poster information desk. Poster authors, must stand beside their poster during the poster session for a Question-and-Answer session with the audience. The presenters who asked for their posters to be printed by our agent “Poster Session Online” can refer to the Poster Information Desk at Floor 0, in order to pick it up. Speaker Center Location: Floor 2 - Tower Lounge Room Speaker Center Opening Hours: Thursday, August 22 Friday, August 23 Saturday, August 24 Sunday, August 25 Monday, August 26 Tuesday, August 27 07:00-19:00 07:00-19:00 07:00-19:00 07:00-19:00 07:00-19:00 07:00-19:00 All Invited Speakers and Oral Presenters are requested to pre-load their presentation 4 hours before their scheduled presentation. For those who have a session in the morning, it is strongly recommended to load the presentation the day before. Every day there will be a poster session for each workshop presentation topic. 18 Social Program Social Program Thursday, August 22 OPENING CEREMONY - 16:45 to 22:00 Gold Room - Floor 2 MiCo Milano Congressi Venue - Piazzale Carlo Magno, 1 (Included in the Registration fee for both delegates and accompanying persons) The inauguration of the 15th INTERNATIONAL CONGRESS OF IMMUNOLOGY will take place at MiCo Milano Congressi. The Ceremony will be followed by a welcome reception. Friday, August 23 NOVARTIS AWARD CEREMONY - 19:30 to 22:00 Gold Room - Floor 2 MiCo Milano Congress Venue - Piazzale Carlo Magno, 1 (Included in the Registration fee for both delegates and accompanying persons) The Award Ceremony will be followed by a reception. Sunday, August 25 ELSE KRÖNER-FRESENIUS AWARD LECTURE - 19:30 to 22:00 Gold Room - Floor 2 MiCo Milano Congress Venue - Piazzale Carlo Magno, 1 (Included in the Registration fee for both delegates and accompanying persons) The Award Ceremony will be followed by a reception. Monday, August 26 OFFICIAL PARTY - 20:30 to 24:00 Chiostri dell’Umanitaria - Via Daverio, 7 Official Party buffet dinner will be held at the beautiful Chiostri dell’Umanitaria followed by a suggestive entertainment. Tickets are on sale at the Registration Desk on August 22 and on August 23, subject to availability. Cost per person: € 50.00 (VAT included). Tuesday, August 27 CLOSING CEREMONY - 19:30 to 20:30 Gold Room - Floor 2 MiCo Milano Congress Venue - Piazzale Carlo Magno, 1 (Included in the Registration fee for both delegates and accompanying persons) Closing Ceremony will take place at the MiCo Congress Venue and it will mark the closing of the 15th INTERNATIONAL CONGRESS OF IMMUNOLOGY. TOURS Different tours are available and purchasable onsite, subject to availability. The Info Tourist Desk is located at the entrance area on Floor 1 at MiCo congress venue, from August 22 to August 24 from 8:00 to 18:00. 19 IUIS Council and Meetings IUIS Council and Meetings IUIS Executive Committee Stefan Kaufmann IUIS President Jorge Kalil IUIS Vice-President Seppo Meri IUIS Secretary General Nicholas King IUIS Treasurer Peter Doherty IUIS Past President IUIS Coucil Members Olivier Boyer, France Xuetao Ca, China Margarida Carneiro, Portugal Alioune Dieye, Senegal Ahmed El-Gohary, Egypt Anna Erdei, Hungary Jeffrey A. Frelinger, USA Shigeo Koyasu, Japan Daniel Lopes, Brazil Alberto Mantovani, Italy Michael J.H. Ratcliffe, Canada Clelia Maria Riera, Argentina Franca Ronchese, New Zealand Christopher E. Rudd, United Kingdom Reinhold E. Schmidt, Germany René A.W. van Lier, Netherlands IUIS MEETINGS Thursday, August 22 09.00-12.30 - 60TH IUIS COUNCIL MEETING - Amber Room 3 Thursday, August 22 13.30-16.30 - IUIS GENERAL ASSEMBLY - Amber Room 4 Friday, August 23 13.30-15.00 - 61TH IUIS COUNCIL MEETING - Amber Room 3 20 Board Meetings and General Assemblies Board Meetings Friday, August 23 10.00-14.00 JOHN WILEY & SONS BOARD LUNCH - Suite 2 Friday, August 23 12.30-15.00 AINI BOARD MEETING - Suite 1 Friday, August 23 16.00-20.00 FIMSA BOARD MEETING - Suite 1 Saturday, August 24 8.00-14.00 EFIS - ELSEVIER EDITORIAL BOARD - Suite 1 Sunday, August 25 15.00-18.00 EFIS EEIG MEETING - Suite 1 General Assemblies Friday, August 23 13.30-15.00 SIICA GENERAL ASSEMBLY Space 4 Friday, August 23 18.30-19.15 AINI GENERAL ASSEMBLY Amber 5+6 21 Awards Awards Else Kröner-Fresenius Award Lecture 19.30-22.00 August 25 - GOLD ROOM The Else Kröner-Fresenius Immunology Award recognizes seminal discoveries in medical immunology and facilitates future research of the award winner. It is endowed with 4 Mio Euro. An international jury of expert immunologists, headed by the IUIS president Prof. Stefan Kaufmann, identified Ruslan Medzhitov HHMI and Yale University, as winner of the award. EFIS ACTERIA Award Ceremony 13.30-15.00 August 23 - AMBER 1+2 The 2013 ACTERIA Prizes awarded by EFIS in Immunology and Allergology single out four early career scientists who will make a difference. The ACTERIA Prizes awarded by EFIS were established to recognize and reward Europe’s young talents in the fields of immunology and allergology. The two ACTERIA Doctoral Thesis Prizes, for the best dissertations defended in the last 3 years, and the two ACTERIA Early Career Research Prizes, going to investigators with up to 10 years postdoctoral experience, carry cash awards plus the financing of three-year research projects to be performed in European institutions. 2013 IUIS Day of Immunology Award Ceremony 13.30-15.00 August 25 - BROWN 3 This year for the first time, IUIS and EFIS have worked together to involve all regional and national societies in a global effort to promote the benefits of immunology research during the International Day of Immunology (DoI) that took place on April 29, 2013. Each participating society designed their campaign using any media of their choice, including posters, film, video, social media, email and regular mail reaching journalists, school teachers, politicians, decision makers and the general public. Awards are being given based on the campaign’s originality, clarity, and impact at national or regional level. All national societies and regional federations were eligible to apply for a prize. 22 national societies applied and named an Ambassador to be the contact person for their campaign. This year, awards totaling 5000 euros will be given to the top 3 public relations campaign for the Day of Immunology: 1. International Day of Immunology Award, given by IUIS - 2000 euros for the best campaign organized by IUIS members 2. European Day of Immunology Award, given by EFIS - 2000 Euros for the best campaign in Europe, where the annual DoI has been celebrated since 2005 3. Award for the Best Newcomer Campaign - 1000 euros given jointly by IUIS and EFIS for the best campaign organized by a candidate participating in the DoI for the first time Prizes will be announced during a special awards ceremony at the ICI Milan, 25 August 2013 from 1:30 to 3:00pm in the BROWN room 3. The winners will have the opportunity to present their campaign to the audience. NOVARTIS Award Ceremony 19.30-22.00 August 23 - GOLD ROOM The Novartis Prizes for Basic and Clinical Immunology are awarded for outstanding achievements in the understanding of immunological processes in health and disease and major discoveries resulting in novel treatments for immunological diseases such as autoimmune and inflammatory diseases, transplantation, infectious diseases, immunotherapy of cancer and allergic and dermatological diseases. The Prizes for Basic and Clinical Immunology are each endowed with SFr 100,000. 22 Awards Awards Sponsored by Scientific Journals AWARDS SPONSORED BY SCIENTIFIC JOURNALS 14.00-15.00 August 24 - BROWN 3 THE JOURNAL OF IMMUNOLOGY YOUNG INVESTIGATOR AWARD 4 prizes awarded by AAI representative(s) NATURE IMMUNOLOGY $ 500 for the best poster in Innate Immunity Prize awarded by Dr. Laurie Dempsey (Senior Editor of NI) NATURE REVIEWS IMMUNOLOGY $ 500 for the best poster in Adaptive Immunity Prize awarded by Dr. Lucy Bird (Chief Editor of NRI) NATURE 1 free subscription for the best poster in Immune receptor and signaling 1 free subscription for the best poster in Immune-mediated disease pathogenesis Prize awarded by Dr. Ursula Weiss (Senior Editor of Nature) SCIENCE 1 free subscription for the best poster in Translational immunology and immune intervention Prize awarded by an ICI representative IMMUNITY (Cell Press) 1 free subscription for the best poster in Host-pathogen Interactions Prize awarded by Dr. Peter Lee (Editor of Immunity) TRENDS IN IMMUNOLOGY (Cell Press) 1 free subscription for the best poster in Innate Immunity Prize awarded by Dr. Peter Lee (Editor of Immunity) 23 Travel Grants Travel grants ICI 2013 Bursaries to Young Immunologists Travel grants funded by ICI 2013 have been assigned to worthy young immunologists. Travel Grants Recipients 1. Aicheler Rebecca (GBR) 2. Bär Eva (SUI) 3. Bar-On Yotam (ISR) 4. Bonaccorsi Irene (ITA) 5. Boström Stéphanie (SWE) 6. Carambia Antonella (GER) 7. Chuang Huai-Chia (TAI) 8. Cook Alistair (AUS) 9. Cuenca Marta (ESP) 10. Dominguez Claudia (USA) 11. Doxaki Christina (GRE) 12. Dudeck Anne (GER) 13. Flaczyk Adam (CAN) 14. Guggino Giuliana (ITA) 15. Hagn Magdalena (AUS) 16. Hanazawa Asami (GER) 17. Hartung Evelyn (GER) 18. He Feng (LUX) 19. Hoeffel Guillaume (SNG) 20. IJspeert Hanna (NED) 21. Jackson Katherine (AUS) 22. Kassianos Andrew (AUS) 23. Kimura Tetsuya (JPN) 24. Laffont Sophie (FRA) 25. Lee Se Na (KOREA) 26. Lo Monaco Elisa (ITA) 27. Lo Presti Elena (ITA) 28. Lund Harald (SWE) 29. Marczy ska Joanna (POL) 30. Marichal Thomas (USA) 31. Messaoudene Meriem (FRA) 32. Moriwaki Kenta (USA) 33. Morvan Maelig (USA) 34. Nadkarni Suchita (GBR) 35. Obata Yuuki (JPN) 36. Ouaguia Laurissa (FRA) 37. Ouchani Farid (FRA) 38. Ramos Ornelia (NED) 39. Rashidi Maryam (AUS) 40. Reboldi Andrea (USA) 41. Schmetterer Klaus (AUT) 42. Schraml Barbara (GBR) 43. Sekai Miho (JPN) 44. Seillet Cyril (AUS) 45. Shimada Kenichi (USA) 46. Spary Lisa (GBR) 47. Szarka Eszter (HUN) 48. Trovato Maria (ITA) 49. Valero-Pacheco Nuriban (MEX) 50. van der Meer Anne (NED) 24 IUIS/GATES Foundation travel grants for young immunologists from developing countries The IUIS and The Bill and Melissa Gates Foundation have assigned 36 travel grants to immunologists from developing countries (non-OECD countries). Travel Grants Recipients 1. Alonso-Vega Cristina (BOL) 2. Amri Manel (ALG) 3. Anavarathavinayagamoorthy Sivagowry (SRI) 4. Bashir Qudsia (PAK) 5. Bobosha Kidist (ETI) 6. Bogolyubova Apollinariya (RUS) 7. Bortoluci Karina (BRA) 8. Chamakh Rym (TUN) 9. Drif Kamar (MAR) 10. Ganji Rakesh (IND) 11. Hsu Li-Chung (TAI) 12. Kabilova Tatyana (RUS) 13. Kammoun Rebai Wafa (TUN) 14. Kone Younoussou (MLI) 15. Lekomtseva Yevgeniya (UKR) 16. Lenac Roviš Tihana (CRO) 17. Matangkasombut Ponpan (THL) 18. Mduluza Takafira (ZIM) 19. Medina Silva Tiago (BRA) 20. Mendez Huergo Santiago (ARG) 21. Mihret Adane (ETI) 22. Milovanovic Marija (SRB) 23. Mohan Mradul (IND) 24. Muñoz-Wolf Natalia (URU) 25. Ndure Jorjoh (GAM) 26. Nemes Elisa (SUD) 27. Nyakundi Ruth (KEN) 28. Panda Saswati (SIN) 29. Parihar Suraj (SUD) 30. Sabour Alaoui Sanaa (TUN) 31. Tian Jie (CHN) 32. Volkava Marharyta (BLR) 33. Wang Wenyan (CHN) 34. Yacoub-Youssef Houda (MAR) 35. Yessoufou Akadiri (BEN) 36. Zakharyan Roksana (ARM) Travel Grants Travel grants ICI-AAI travel grants for immunologists from developing countries The American Association of Immunologists has assigned 20 travel grants to immunologists from developing countries (USAID Developing and Advanced Developing Countries). 1. Atoum Manar (JOR) 2. Best Ivan (PER) 3. Bhattacharyya Arindam (IND) 4. Blinova Elena (RUS) 5. Capozzo Alejandra (ARG) 6. Clavijo Salomon Maria (BRA) 7. Dergan Dylon Sebastián (ARG) 8. Dias de Melo Guilherme (BRA) 9. Dubey Shweta (IND) 10. Dzoro Sheron (BOT) 11. Gustiananda Marsia (INA) 12. Kanga Uma (IND) 13. Maneerat Yaowapa (TAI) 14. Mihaylova Nikolina (BUL) 15. Mongini Claudia (ARG) 16. Ode Odugbo Moses (NGR) 17. Ramesh Kumar (IND) 18. Retshabile Gaone (BOT) 19. Wada-Kura Aminu (NGR) 20. Yap Fei-Ling (MAS) Travel grant opportunities provided by National Societies and Immunological Federations: • • • • • • • • • • • American Association of Immunologists Austrian Society for Allergology and Immunology Australasian Society for Immunology Brasilian Society of Immunology British Society for Immunology Canadian Society of Immunology EFIS European Federation of Immunological Societes French Society of Immunology German Society for Immunology Japanese Society for Immunology Italian Society of Immunology, Clinical Immunology and Allergology • Swiss Society for Allergology and Immunology • Turkish Society of Immunology 25 Immunology Courses BASIC IMMUNOLOGY COURSE COURSE FACULTY: August 22 - 9.00 - 17.00 BROWN 3 Chairs: Abul K. Abbas, MD (University of California San Francisco, USA) Andrew H. Lichtman, MD, PhD (Harvard Medical School, Boston, USA) Abul K. Abbas (USA) Introduction to the Immune System Andrew H. Lichtman (USA) Innate Immunity Abul K. Abbas (USA) Antigen Presentation, T Cell Activation and Costimulation Abul K. Abbas (USA) T Cell Subsets, Cytokines Andrew H. Lichtman (USA) CD8, NK and NK T Cells Andrew H. Lichtman (USA) B Cells and Antibodies Abul K. Abbas (USA) T Cell Regulation and Tolerance Abul K. Abbas (USA) Autoimmunity and Immunological Diseases CLINICAL IMMUNOLOGY COURSE August 22 - 8.45 - 17.00 AMBER 5+6 August 23-27 - 8.00 - 8.45 AMBER 1+2 Chair: Reinhold E. Schmidt 26 Friday, August 23 Cezmi A. Akdis (CHE) Allergies Saturday, August 24 Bodo Grimbacher (GBR) Primary immunodeficiencies Sunday, August 25 Roland Martin (CHE) Inflammatory diseases of the CNS Monday, August 26 Herve Fridman (FRA) Immune surveillance of tumors Tuesday, August 27 Kathryn Wood (GBR) Transplant tolerance SATELLITE MEETING XXIII AINI CONGRESS Italian Association of Neuroimmunology The Neurobiology of the Immune System August 22, 2013 OPENING CEREMONY Luciano Adorini, President 15th ICI - Opening speech Stefan H.E. Kaufmann, IUIS President - Welcome address Vincenzo Barnaba, President SIICA - Welcome address Cristina Tajani, Milan City Councillor for Cultural Affairs - Welcome address Sandro De Palma, piano Domenico Cimarosa Cinque Sonate per fortepiano Domenico Scarlatti Sonata K. 380 in mi maggiore - Andante comodo Sonata K.427 in sol maggiore - Più presto possibile Pastorale (Allegretto) e Capriccio (Vivace) 16.45 - 19.15 GOLD ROOM Jules Hoffmann (FRA) - Lecture Innate immunity: from flies to humans Introduced by Stefan H.E. Kaufmann Maria Chiara Pavone e Graciela Dorbessan, sopranos Sandro De Palma, piano Giacomo Puccini Mi chiamano Mimì (from La Bohème) Graciela Dorbessan, Soprano Gioachino Rossini L’invito (from Soirées musicales) Maria Chiara Pavone, Soprano Giacomo Puccini Vissi d’arte (from Tosca) Graciela Dorbessan, Soprano Gaetano Donizetti Lu trademiento (Neapolitan song) Maria Chiara Pavone, Soprano Gaetano Donizetti I bevitori (Duet for two sopranos and piano) Graciela Dorbessan e Maria Chiara Pavone, Sopranos Rino Rappuoli (ITA) - Lecture Designing vaccines for the 21st century society Introduced by Vincenzo Barnaba Francesca Dego, violin Niccolò Paganini Cantabile per violino e pianoforte (Sandro De Palma, piano) Capriccio n. 20 (Allegretto) Capriccio n. 21 (Amoroso, presto) Capriccio n. 24 (Tema con variazioni, quasi presto) Welcome Cocktail 5.000 downloads of the musical program (Cimarosa and Scarlatti) will be available on website www.sandrodepalma.it/intranet User-ID: 15ICI Password: muzio2013 27 Chair: Abul Abbas (USA) Rolf Zinkernagel (CHE) On immunity or what immunology is all about PS.02 - PERSPECTIVES IN IMMUNOLOGY Chair: Lorenzo Moretta (ITA) Alain Fischer (FRA) T cell immunodeficiencies PL.01 - PLENARY LECTURE 12.30 - 13.15 SPACE 1+2 Chair: Vishna Dixit (USA) Shizuo Akira (JPN) Mitochondrial transport by microtubule acetylation is essential to NLRP3-inflammasome activation LL.01 - LUNCHTIME LECTURE 12.30 - 13.15 BROWN 3 Chair: David Hafler (USA) Abul Abbas (USA) Immunological tolerance: mechanisms and therapeutic applications LL.03 - LUNCHTIME LECTURE Chair: Matthew Albert (FRA) Rafi Ahmed (USA) T cell memory and exhaustion 12.30 - 13.15 SPACE 4 12.30 - 13.15 12.30 - 13.15 BROWN 1+2 GOLD ROOM 12.30 - 13.15 SPACE 3 LL.05 - LUNCHTIME LECTURE Chair: Fred Alt (USA) Jean Claude Weill (FRA) Memory LL.02 - LUNCHTIME LECTURE Chair: Eric Vivier (FRA) Lorenzo Moretta (ITA) Human NK cells: from basic research to the therapy of high risk leukemias LL.04 - LUNCHTIME LECTURE Chair: Hannes Stockinger (AUT) Paola Ricciardi Castagnoli (SGP) NFAT control of innate immunity LL.06 - LUNCHTIME LECTURE Chair: Christine Biron (USA) Hidde Ploegh (USA) Cloned mice as immunological tools LL.07 - LUNCHTIME LECTURE Chair: Gordon Brown (GBR) Yvette van Kooyk (NLD) Glycans as dendritic cell targeting strategy for the induction of immunity and tolerance 18.30 - 19.15 GOLD ROOM 14.00 - 15.00 BROWN 3 12.30 - 13.15 AMBER 1+2 28 8.50 - 9.20 SPACE 1+2 PS.01 - PERSPECTIVES IN IMMUNOLOGY 9.30 - 10.15 GOLD ROOM 8.50 - 9.20 GOLD ROOM Main Lectures August 23, 2013 SPECIAL LECTURE Chair: Marco Colonna (USA) Ivan Lefkovitz (CHE) Contribution of Italian scientists to the 30 years of Basel Institute for Immunology success PL.02 - PLENARY LECTURE Chair: Philippa Marrack (USA) Ruslan M. Medzhitov (USA) Inflammation and tissue homeostasis S1 - PATHWAYS IN INFLAMMATORY DISEASES S2 - THERAPY OF AUTOIMMUNE AND AUTOINFLAMMATORY DISEASES Chairs: Paola Allavena (ITA) Yoichiro Iwakura (JPN) Lars Klareskog (SWE) S1.01 Gene-environment interaction studies as a basis for unraveling specificity of adaptive immunity in rheumatoid arthritis Frank Nestle (GBR) S1.02 Inflammatory skin disease: from pathways to targeted therapy Jeffrey V. Ravetch (USA) S1.03 A general mechanism for modulating immunoglobulin effector activity Suzanne Ostrand-Rosemberg (USA) S1.04 Tumor-induced myeloid-cell mediated immune suppression: it is all the RAGE Mitchell Kronenberg (USA) S1.05 Regulation of inflammation and mucosal innate immunity by HVEM, a TNF super family receptor Chairs: Moncef Zouali (FRA) Pierluigi Meroni (ITA) Peder Olofsson (USA) S2.01 Neural circuitry regulating immunity: identification of T-ChAt as a discrete T cell subset Roland Martin (DEU) S2.02 Antigen-specific tolerization approaches in multiple sclerosis - principles and recent data David Wraith (GBR) S2.03 Negative feedback regulation of inflammatory autoimmune responses Jeffrey A. Bluestone (USA) S2.04 Treg therapy in autoimmunity: preclinical and clinical experiences Josef Smolen (AUT) S2.05 Treating rheumatoid arthritis: recent achievements and current prospects 10.20 - 12.25 SPACE 1+2 10.20 - 12.25 GOLD ROOM Parallel Symposia August 23, 2013 S4 - LEUKOCYTE SIGNALING Chair: 10.20 - 12.25 BROWN 3 Chairs: Lucienne Chatenoud (FRA) Foo Y. Liew (GBR) Gordon Brown (GBR) S3.01 C-type lectins and anti-fungal immunity Dan R. Littman (USA) S3.02 Commensal microbe-dependent induction of effector T cells in the lamina propria Gabriel Nunez (USA) S3.03 Regulation of pathogen colonization by virulence factors and the microbiota Francesca Granucci (ITA) S3.04 Mechanisms and consequences of NFAT signaling pathway activation downstream of PRRs in innate immune cells Giulio Superti Furga (AUT) S3.05 IFITs, TLRs and innate anti-viral molecular networks Peter Murray (USA) Doreen Cantrell (GBR) S4.01 T cell metabolism and differentiation Hua Yu (CHN) S4.02 STAT3 in tumor immune regulation: opportunities for clinical translation Kai W. Wucherpfennig (USA) S4.03 Control of T cell signaling by membrane binding of TCR-CD3 ITAMs Attila Mocsai (HUN) S4.04 Tyrosine kinases in leukocyte activation and migration Oreste Acuto (GBR) S4.05 Proteomics of T cell signaling: seeing more and better S5 - MYELOID CELLS S6 - LYMPHOCYTE DEVELOPMENT Chairs: Angel Lopez (AUS) Angel Corbi (ESP) John Hamilton (AUT) S5.01 Colony stimulating factors and macrophage lineage phenotypes Miriam Merad (USA) S5.02 The regulation of the dendritic cell lineage Hans-Reimer Rodewald (DEU) S5.03 Fate mapping the origins of fetal and adult myeloid cells Marco Cassatella (ITA) S5.04 Uncovering the regulation of gene expression in human neutrophils William Nauseef (USA) S5.05 Host vs. microbe in the human neutrophil phagosome Chairs: Harald von Boehmer (USA) Stephan Meuer (DEU) Ellis L. Reinherz (USA) S6.01 Mechanotransduction processes involved in T cell development and cognate recognition Ton Schumacher (NLD) S6.02 Analysis of antigen-specific T cell responses at the single cell level Bruno Kyewski (DEU) S6.03 Generating self-antigen diversity by genome scanning in single thymic epithelial cells Kristen A. Hogquist (USA) S6.04 The role of self recognition in the development of various T cell subsets Gennaro De Libero (SGP) S6.05 Butyrophilin 3A1 binds phosphorylated antigens and stimulates human T cells 10.20 - 12.25 SPACE 4 10.20 - 12.25 SPACE 3 10.20 - 12.25 BROWN 1+2 S3 - MICROBIAL TRIGGERS FOR INFLAMMATION 29 Sponsored Sessions August 23, 2013 MULTICOLOR IMMUNOPHENOTYPING WITH BRILLIANT VIOLET™ FLUOROPHORES 14.00 - 15.00 SPACE 3 with the contribution of Biolegend Chairs: Hans-Martin Jack (DEU) Carsten Wiethe (DEU) Scientific Application Manager, BioLegend Expanding multicolor options in flow cytometry with novel Brilliant Violet™ fluorophores Eva Tolosa (DEU) University Medical Centre Hamburg-Eppendorf, Hamburg, Germany Improving immune effector cell analysis with Brilliant Violet™ fluorophores THE NEUROBIOLOGY OF THE IMMUNE SYSTEM with the contribution of International Society of Neuroimmunology, Target Brain Chairs: Carlo Avolio (ITA) - Antonio Uccelli (ITA) 15.10 - 18.15 AMBER 5+6 Michal Schwartz (ISR) Immunity shapes brain function in health, disease and aging: specificity, location and mechanism Gianvito Martino (ITA) From brain homeostasis to tissue repair: the immunomodulatory role of neural stem cells Zaal Kokaia (SWE) Stroke, stem cells and inflammation Michal Tomas Olsson (SWE) Genes and lifestyle factors, and their interactions leading to CNS autoimmune disease: multiple sclerosis Luca Battistini (ITA) Immunological hallmarks of multiple sclerosis Roberto Furlan (ITA) Microglia microvescicles: a pathogenic and prognostic role is neuroinflammatory and neurodegenerative conditions NOVARTIS PRIZES FOR IMMUNOLOGY AWARD CEREMONY 19.15 - 20.15 GOLD ROOM Introduction by Hidde Ploegh (USA) Address and handover of the prizes by Dhavalkumar Patel, MD, PhD, Head Europe, Novartis Institutes for Biomedical Research BASIC IMMUNOLOGY PRIZE Laudation by Anne O’Garra (GBR) Lectures by the Prize winners CLINICAL IMMUNOLOGY PRIZE Laudation by Diane Mathis (USA) Lecture by the Prize winner 30 Workshops August 23, 2013 W1.11 - TOLL-LIKE AND PATTERN RECOGNITION RECEPTORS W1.11.11 - Bacterial 23S rRNA is recognized by the endosomal TLR13 unless it is modified to constitute erythromycin resistance Anne Krüger, M. Oldenburg, R. Ferstl, A. Kaufmann, G. Nees, J. Buer, H. Wagner, S. Bauer, H. Hochrein, C.J. Kirschning Essen, Germany IL1.11.01 - Regulation of the innate immune responses in wild mice Alexander Poltorak, T. Volkova, I. Kurbatova, V. Ilyuha, U. Bagina, D. Ram Boston, United States W1.11.01 - Emerging roles of an innate immune regulator TAPE in the endosomal Toll-like receptor (TLR) and cytosolic RIG-I-like receptor (RLR) pathways Pin Ling, K. Chen, C. Yang, Y. Lo, C. Huang, T. Tan Tainan, Taiwan 15.10-18.15 GOLD ROOM Chairs: John Kagan (USA) Alexander Poltorak (USA) W1.11.02 - Smurf2 negatively regulates RIG-I-like receptor-mediated immune signalling Yu Pan, J. Zhang Beijing, China W1.06 - MACROPHAGES Chairs: Antonio Sica (ITA) Subhra Biswas (SGP) W1.06.01 - Stabilin-1/CLEVER-1 defines an immune suppressive monocyte population Senthil Palani, K. Elima, M. Salmi, S. Jalkanen Turku, Finland W1.11.05 - CD14 as a key regulator of TLR-mediated responses of microglia Hana Janova, T. Regen, D. van Rossum, A. Götz, W. Brück, U. Hanisch Goettingen, Germany W1.06.02 - Mice depleted of LyzM+ macro-phages develop chronic inflammation and deregulated adaptive immunity Roham Parsa, H. Lund, X. Zhang, A.O.G. Cacais, A.M. Georgoudaki, M. Karlsson, R.A. Harris Stockholm, Sweden W1.11.06 - Bruton’s tyrosine kinase plays an essential role in TLR-dependent human DC activation Vassilios Lougaris, M. Vitali, M. Baronio, G. Tampella, L. Tassone, A. Soresina, R. Badolato, A. Plebani Brescia, Italy 15.10-18.15 BROWN 3 15.10-18.15 GOLD ROOM W1.11.04 - The evolutionary landscape of the NLR family is reflected in the species-specific response to infection Tom P. Monie, L. Hopkins, J. Boyle, W. Amos, C. Bryant Cambridge, United Kingdom W1.11.08 - NLRC5-mediated regulation of MHC class I immune responses Koichi S. Kobayashi, I. Downs, A. Biswas, T. Meissner, Y. Liu, K. Lee, A. Li College Station, USA W1.11.13 - Redox-based control of synergy and antagonism among TLRs modulates cytokine production by monocytes Rosa Lavieri, L. Delfino, P. Piccioli, E. Repaci, P. Castellani, A. Rubartelli Genoa, Italy W1.11.14 - A TNF-CCL20-CCR6 axis drives Nod1-induced B cell recruitment Jorg H. Fritz Montreal, Canada W1.11.03 - PIAS1 negatively modulates virus triggered type I IFN signalling by blocking the DNA binding activity of IRF3. R. Li, Y. Pan, D. Shi, Y. Zhang, Jun Zhang Beijing, China W1.11.07 - Lysosomal oligopeptide transporter SLC15A4 regulates Toll-like receptor 7/9-mediated autoantibody production Toshihiko Kobayashi, T. Okamura, N. Toyama-Sorimachi Tokyo, Japan W1.11.12 - TLR triggered MAPK signalling is responsible for the regulatory phenotype of macrophages in response to Schistosoma mansoni cercarial secretions David E. Sanin, A.P. Mountford York, United Kingdom W1.06.03 - Glucocorticoid-induced leucine zipper (GILZ) inhibits inflammatory activation in macrophages via reduced MAPK signalling: role in endotoxin tolerance Jessica Hoppstädter, T. Stadter, S. Bruscoli, C. Riccardi, A.K. Kiemer Saarbruecken, Germany W1.06.04 - CD300a is a new hypoxia-inducible gene and a regulator of proinflammatory cytokine production in human monocytes and macrophages Federica Raggi, F. Blengio, L. Varesio, M. Bosco Genoa, Italy W1.11.09 - Co-ligation of TLR3 and Dectin-1 agonists potentiates Th1 polarization capability on monocyte derived Langerhans cells in vitro Ivan Rajkovic, A. Dragicevic, S. Vasilijic, D. Vucevic, B. Bozic, D. Mihajlovic, M. Markovic, M. Colic Belgrade, Serbia W1.06.05 - Physical interaction between miR-155 and miR-146a gene loci: Co-regulation during macrophage activation and induction of endotoxin tolerance Christina Doxaki, A. Eliopoulos, C. Spilianakis, C. Tsatsanis Heraklion, Greece W1.11.10 - TLR-9 dependent dendritic cells activation by filamentous bacteriophage targeting DEC-205 Rossella Sartorius, L. D’Apice, M. Trovato, G. De Leo, A. De Matteis, P. Barba, P. De Berardinis Naples, Italy W1.06.06 - Single cell dynamics of macrophage activation and signalling James S. Bagnall, L. Schmidt, D. Spiller, M.R.H. White, P. Paszek Manchester, United Kingdom 31 Workshops August 23, 2013 W1.06.07 - Revisiting the ontogeny of the mononuclear phagocyte system: embryonic and adult hematopoietic contributions. G. Hoeffel, Florent Ginhoux Singapore, Singapore 15.10-18.15 BROWN 3 W1.06.09 - Targeting MIF/CD74 signalling pathway to dampen acute inflammation in autoimmune diabetes Hannelie Korf, B. Stijlemans, K. Ciotkowski, J. Laureys, M. Gilis, C. Gysemans, C. Mathieu Leuven, Belgium 15.10-16.40 SPACE 1 W1.06.08 - CX3CR1hi Ly6C- monocytes play an anti-inflammatory role during liver inflammation Y. Morias, Chloe Abels, D. Laoui, E. Van Overmeire, E. Schouppe, F. Tacke, P. De Baetselier, A. Beschin Brussels, Belgium W5.17.03 - Defective IFN--induced indoleamine 2,3dioxygenase production in patients with macrophage activation syndrome Karen Put, F. Fallarino, A. Avau, S. Put, B. Bader-Meunier, B. Van den Eynde, C. Orabona, P. Quartier, C. Wouters, P. Matthys Leuven, Belgium W1.06.10 - Role of M1 and M2 macrophages in phagocytosis and degradation of amyloid-beta in Alzheimer's disease transgenic mice Harald Lund, X. Zhang, R.A. Harris Stockholm, Sweden W1.06.12 - IL-4 stimulates macrophage soluble Flt-1 and inhibits murine experimental choroidal neovascularisation Wei-Kang Wu, L.B. Nicholson, D.O. Bates, A.D. Dick Bristol, United Kingdom W5.01 - CYTOKINE REGULATION IN DISEASE Chairs: Patricia Bozza (BRA) Santo Landolfo (ITA) W1.06.13 - CCR2 expression by macrophages promotes tumor progression through induction of IL-10 production Nicoletta Caronni, B. Savino, M. Locati, R. Bonecchi Milan, Italy IL5.01.01 - Dengue infection triggers platelet-derived IL-1: Mechanisms and roles to increased vascular permeability E.D. Hottz, J. Lopes, C. Freitas, F.A. Bozza, Patricia T. Bozza Rio de Janeiro, Brazil 15.10-16.40 SPACE 1 IL5.17.01 - Epigenetic regulation following AhR activation leads to suppression of inflammatory and autoimmune diseases Prakash Nagarkatti, M. Rouse, N. Singh, M. Nagarkatti South Carolina, United States IL5.17.02 - Autoinflammatory diseases Anna Rubartelli Genova, Italy W5.17.01 - The molecular link between PSTPIP1 and S100A8/S100A9 in autoinflammatory diseases Selina Fassl, D. Holzinger, J. Austermann, T. Vogl, J. Roth Muenster, Germany W5.17.02 - Increased Nlrp3-dependent IL-1 secretion in patients with familial mediterranean fever: correlation with Mefv genotype Alessia Omenetti, S. Carta, L. Delfino, A. Martini, M. Gattorno, A. Rubartelli Genoa, Italy 32 15.10-16.40 SPACE 2 W1.06.14 - Matrix reprogramming of immune cells and its disturbance in tumor Igor Malyshev Moscow, Russian Federation Chairs: Prakash Nagarkatti (USA) Anna Rubartelli (ITA) W5.17.05 - Identification of commensal flora associated antigen, as a pathogenic factor of autoimmune pancreatitis Yoshihiro Abe, N. Yanagisawa, I. Haruta, K. Shiratori, J. Yagi Tokyo, Japan W5.17.06 - Soluble CD91/LRP1 is elevated in the sera of a subset of children with different inflammatory diseases Marianna M. Newkirk, R. Balhous, A. Cimino, Z. Li, S. Magalhaes, A. Bar-Or, A. Rosenberg Montreal, Canada W1.06.11 - IL-17 receptor A regulates renal inflammation and aggravates fibrosis Shuwang Ge, B. Hertel, H. Haller, S. von Vietinghoff Hannover, Germany W5.17 - AUTOINFLAMMATORY DISEASES W5.17.04 - Study MHC-II presentation of multiple sclerosis associated autoantigen using antibodies with T cell receptor specificity Efrat Altman, Y. Reiter Haifa, Israel IL5.01.02 - Nuclear DNA sensor IFI16 as circulating protein in autoimmune diseases is a signal of damage that impairs endothelial cells through high-affinity membrane binding Marco De Andrea, M. Bawadekar, F. Gugliesi, V. Dell’Oste, V. Caneparo, A. Tincani, M. Gariglio, S. Landolfo Turin, Italy W5.01.01 - The TNF family member TL1A: a key player in type 2 immunity in both adaptive and innate lymphocytes F. Meylan, E. Hawley, L. Barron, P. Penumetcha, J. Barlow, A. Richard, T. Wynn, A. Mckenzie, I. Gery, Richard M. Siegel Bethesda, USA W5.01.02 - Oxazolone and ethanol induce colitis in NOD-scid IL2R null mice engrafted with human peripheral blood mononuclear cells Roswitha Gropp, T. Nolte, M. Zadeh-Khorasani, F. Rueff, A. Wollenberg, V. Gülberg, E. Wolf, M. Siebeck Munich, Germany W5.01.03 - Chronic infection with Toxoplasma gondii aggravates experimental sublethal sepsis induced by CLP and predisposes to septic shock Maria C. Souza, D.M. Fonseca, A. Kanashiro, L. Benevides, G. Bonfá, D. Golenbock, R.T. Gazzielli, J.C.F. Alves-Filho, F.Q. Cunha, J.S. Silva Ribeirão Preto, Brazil 15.10-16.40 SPACE 2 W5.01.04 - Foxo3 transcription factor controls susceptibility to central nervous system inflammation Caroline Stienne, N. Carrié, A. Dejean Toulouse, France W5.01.05 - Factor Xa and thrombin stimulate an inflammatory and fibrotic response by retinal pigment epithelial cells: a role in vitreoretinal disorders? Jeroen Bastiaans, J.C. van Meurs, C. van Holten, M. Smits - te Nijenhuis, M.J. Kolijn - Couwenberg, N.M.A. Nagtzaam, M.P. van Hagen, R.W.A.M. Kuijpers, H. Hooijkaas, W.A. Dik Rotterdam, Netherlands 15.10-16.40 SPACE 3 Workshops August 23, 2013 W2.01 - LEUKOCYTE SIGNALING Chairs: Emilio Hirsch (ITA) Vaclav Horejsi (CEC) W5.01.06 - Aberrant expression of IL-22RA1 on hematopoietic cells as immunologically signature of primary Sjogren’s syndrome and Sjogren-associated non-Hodgkin lymphomas Giuliana Guggino, F. Ciccia, A. Rizzo, S. Raimondo, A. Giardina, G. Giardina, G. Sireci, R. Alessandro, F. Dieli, G. Triolo Palermo, Italy W2.01.01 - The recruitment and activation of phosphatidylinositol 4-phosphate 5-kinases critically regulate CD28-dependent signalling responses Loretta Tuosto, M. Muscolini, C. Camperio, C. Capuano, S. Caristi, E. Piccolella, R. Galandrini Rome, Italy W2.01.02 - Terminal transport of lytic granules to the immune synapse is mediated by the kinesin1/Slp3/Rab27a complex Gaël Menasche, M. Kurowska, N. Goudin, N. Nehme, M. Court, J. Garin, A. Fischer, G. de Saint Basile Paris, France IL2.10.01 - Understanding symptomatic infections in order to avoid initiation of autoimmunity Christian Munz Zurich, Switzerland 15.10-16.40 SPACE 4 W2.10 - AUTOPHAGY AND CELL DEATH IN THE IMMUNE SYSTEM Chairs: Christian Münz (CHE) David Wallach (ISR) W2.10.01 - Human and mouse mononuclear phagocytes are the only leukocyte subset expressing functional death receptors for Trail Cristina Belgiovine, M. Liguori, G. Germano, C. Buracchi, A. Mantovani, P. Allavena Milan, Italy W2.01.04 - Molecular tuning of telomerase activity in highly differentiated human primary CD28−CD27− T cells Alessio Lanna, S.M. Henson, D. Escors, A.N. Akbar London, United Kingdom W2.01.06 - The impact of arginine methylation on BCR signalling Simona Infantino, A. Light, K. O’Donnell, S. Richard, D. Tarlinton Melbourne, Australia W2.10.02 - Target cell death is necessary for cytotoxic T cell detachment and serial killing Misty R. Jenkins, J.A. Lopez, J.A. Rudd-Schmidt, I. Voskoboinik, J.A. Trapani Melbourne, Australia W3.03 - THYMIC SELECTION AND T CELL DEVELOPMENT W2.10.03 - The switch in T cell survival: Cross-regulation between homeostasis and antigen-induced activation Susanne Heinzel, P. Koenen, J. Zhang, A. Strasser, P. Hodgkin Parkville, Australia W2.10.05 - p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP Harsha S. Madapura, D. Salamon, K.G. Wiman, S. Lain, G. Klein, E. Klein, N. Nagy Stockholm, Sweden W2.01.03 - The potassium channel KCNK3 determines calcium signalling pathways in T lymphocytes Stefan Bittner, H. Wiendl, S.G. Meuth Münster, Germany W2.01.05 - The expression and phosphorylation of HS1 protein are finely tuned in normal and leukemic B cells Cristina Scielzo, E. ten Hacken, M.T.S. Bertilaccio, M. Ponzoni, U. Restuccia, A. Bachi, P. Ghia, F. Caligaris-Cappio Milan, Italy Chairs: Part Peterson (FIN) Pawel Kisielow (POL) 15.10-16.40 AMBER 1+2 15.10-16.40 SPACE 3 IL2.10.02 - Regulation of inflammation and cell-death trough interactions of RHIM-domain protein kinases with caspase-8 David Wallach, T. Kang, S. Yang, B. Toth, A. Rajput, J. Kim, A. Kovalenko Rehovot, Israel W2.10.04 - IFN- induces an autophagy-mediated antimicrobial response against Mycobacterium leprae in human monocytes Bruno J. Silva, P.R. Andrade, T.P. Amadeu, V. Diniz, S. Côrte-Real, V.C. Valentim, H. Ferreira, J.A.C. Nery, E.N. Sarno, R.O. Pinheiro Rio de Janeiro, Brazil W2.10.06 - Autophagy facilitates TLR4,3-triggered migration and invasion of lung cancer cells by promoting chemokine and IL-6 production through maintaining TRAF6 ubiquitination Zhenzhen Zhan, X. Zhang, H. Fan, Z. Liu Shanghai, China IL3.03.01 - Role of the affinity of TCR-self peptide interaction in commitment to CD4+Foxp3+ and CD4+Foxp3- T cells and in shaping their TCR repertoires L. Wojciech, L. Ignatowicz, Pawel Kisielow Wroclaw, Poland IL3.03.02 - Anti-cytokine autoantibodies in APECED correlate with chronic mucocutaneous candidiasis Pärt Peterson, J. Kärner, K. Kisand Tartu, Estonia 33 W3.03.01 - Novel role for heparan sulfate in thymic development of CD8+ T cells David Anak Simon Davis, C.R. Parish Canberra, Australia 15.10-16.40 AMBER 1+2 W3.03.02 - B cells engender thymic Tregs Stacey N. Walters, K.E. Webster, S. Daley, S.T. Grey Sydney, Australia W3.03.03 - Involvement of commensal bacteria in thymic Aire expression Akihito Nakajima, N. Negishi, H. Tsurui, M. Nanno, H. Yagita, K. Okumura, S. Habu Tokyo, Japan 15.10-16.40 AMBER 7+8 Workshops August 23, 2013 W4.13 - IMMUNE REGULATION AT BARRIER SITES W3.03.05 - Aire-mediated central tolerance includes naïve but not post-translational modified selfantigens Bruno Raposo, P. Merky, R. Holmdahl, J. Bäcklund Stockholm, Sweden W4.13.01 - Intestinal epithelium-intrinsic Notch signalling maintains mucosal immune homeostasis by ensuring epithelial barrier functions Yuuki Obata, D. Takahashi, Y. Furusawa, S. Hori, H. Ohno, K. Hase Tokyo, Japan Chairs: Piergiuseppe De Berardinis (ITA) Markus F. Neurath (DEU) Chairs: Carlo Pucillo (ITA) Marika Sarfati (CAN) IL1.02.01 - Mast cells and regulatory cells: a dialogue that can last a lifetime Carlo Pucillo Udine, Italy W4.13.02 - Oral administration of poly-reactive highaffinity IgA monoclonal antibody against intestinal microbiota improved inflammatory colitis in mice Shinsaku Okai, Y. Horii, Y. Shiraki, S. Matsumoto, T. Naitoh, M. Nanno, K. Yamamoto, K. Kurokawa, S. Nomura, R. Shinkura Nagahama, Japan 15.10-16.40 BROWN 1 W1.02 - MAST CELLS W4.13.03 - Caspase-8 is essential to maintain intestinal barrier function in response to mucosal pathogens Claudia Günther, B. Buchen, H. Neumann, M. Neurath, C. Becker Erlangen, Germany IL1.02.02 - Basophils: new key players in lung and intestinal Th2 or Th17-associated chronic inflammatory disorders Marika Sarfati Montreal, Canada W4.13.04 - CD200 receptor signalling facilitates murine cytomegalovirus persistence in mucosal tissue Gabrielle Stack, M. Marsden, M.A. Stacey, E. Jones, R.J. Snelgrove, S.M. Cuff, A.M. Gallimore, A.N. Barclay, G.W.G. Wilkinson, I.R. Humphreys Cardiff, United Kingdom W1.02.01 - Seven color flow cytometry analyses of Allergin-1 expression and function on human primary bronchoalveolar and nasal mast cells Kei Nagai, S. Tahara-Hanaoka, A. Shibuya Tsukuba, Japan W4.13.05 - Endoplasmic reticulum stress aggravates CVB3-induced myocarditis by promoting NF-B-mediated proinflammatory cytokine production Yan Yue, S. Xiong, X. Zha, W. Xu Suzhou, China W1.02.02 - Soluble CD14 is necessary for LPS-mediated signalling in human intestinal mast cells Sibylle A. Brenner, S.C. Bischoff, A. Lorentz Stuttgart, Germany W4.13.06 - Impaired maintenance of gut homeostasis in mice lacking GGTase-I in intestinal epithelial cells Rocío López Posadas, M.O. Bergö, C. Becker, F. Sánchez de Medina, M.F. Neurath, I. Atreya Erlangen, Germany W1.02.03 - Siglec-7 is an Inhbitory receptor on human mast cells Sa'ar Mizrahi, B.F. Gibbs, L. Karra, M. Ben-Zimra, F. Levi-Schaffer Jerusalem, Israel W1.02.04 - The S1P/S1PR2 axis controls T-cell infiltration in a mast cell-dependent mouse model of acute pulmonary inflammation M.M. Price, Y.T. Falanga, J.J. Ryan, R. Sabbadini, S. Spiegel, Carole A. Oskeritzian Columbia, USA 15.10-16.40 BROWN 2 15.10-16.40 AMBER 7+8 W1.02.06 - Mast cells determine the adaptive immune response in contact hypersensitivity Anne Dudeck, J. Dudeck, M. Gunzer, A. Roers Dresden, Germany W3.03.04 - A key role for PTPN22 in setting the threshold for natural and inducible regulatory T cell development Georgia Fousteri, I. Deberardinis, T. Jofra, S. Stanford, N. Bottini, M. Battaglia Milan, Italy W3.03.06 - Functional study of WW domain-containing oxidoreductase in T cells Tsung-Hao Chang, L. Hs Tainan, Taiwan 34 W1.02.05 - IgE-dependent mast cell hyperplasya in the intestine of cystic fibrosis mouse model needs KCNN4 channel activity T.T. Riquelme, L.P. Cid, F.V. Sepúlveda, Carlos A. Flores Valdivia, Chile W5.08 - ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASES Chairs: Goran Hansson (SWE) Michelle Letartre (CAN) IL5.08.01 - T cells regulate lipid metabolism and vascular stability. Role in atherosclerosis Goran K. Hansson Stockholm, Sweden Workshops August 23, 2013 IL5.08.02 - Anti-VEGF therapy normalizes pulmonary vasculature in Endoglin and Alk1 heterozygous mice Michelle Letarte, D.S. Ardelean, M. Jerkic, M. Peter Toronto, Canada W5.12.02 - Impaired TNF production by dendritic cells from rheumatoid arthritis patients upon contact with Porphyromonas gingivalis Kim C.M. Santegoets, M.H. Wenink, W.B. van den Berg, T.R.D.J. Radstake Utrecht, Netherlands 15.10-16.40 BROWN 2 W5.08.02 - Genetically controlled myocardial expression of CXCL9 may be responsible for the selective migration of Th1 T cells and magnitude of myocarditis in Chagas disease cardiomyopathy Edecio Cunha-Neto, L. Nogueira, R.H. Santos, B.M. Ianni, A. Frade, L. Benvenuti, E. Donadi, B. Saba, A. Fragata, J. Kalil Sao Paulo, Brazil W5.08.03 - TGF- signalling in T cells promotes stabilization of atherosclerotic plaques through an IL-17 dependent pathway Anton Gistera, A.K. Robertson, J. Andersson, D.F.J. Ketelhuth, O. Ovchinnikova, S.K. Nilsson, A.M. Lundberg, M.O. Li, R.A. Flavell, G.K. Hansson Stockholm, Sweden 16.45-18.15 SPACE 1 W5.08.01 - Circulating CD40+ and CD80+ B cell subsets are opposingly associated with risk of stroke P. Mantani, I. Ljungcrantz, L. Andersson, R. Alm, B. Hedblad, H. Björkbacka, J. Nilsson, Gunilla N. Fredrikson Malmö, Sweden W5.08.05 - TIPE2 prevents atherosclerosis by negatively regulating macrophage responses to oxLDL Y. Lou, Suxia Liu, G. Zhang, Y. Chen, Y. Zhang Ji'nan, China Chairs: Gianpietro Semenzato (ITA) Thomas A. Wynn (USA) IL5.02.01 - Regulation of wound healing and fibrosis by macrophages Thomas A. Wynn, L. Borthwick, L. Barron, R.W. Thompson, K. Vannella, K. Kindrachuk, K. Hart, A.W. Cheever, T.R. Ramalingam, P.J. Murray Bethesda, United States W5.12 - RHEUMATOID ARTHRITIS AND OTHER INFLAMMATORY JOINT DISEASES 16.45-18.15 SPACE 2 16.45-18.15 SPACE 1 Chairs: Olivier Boyer (FRA) Claudio Lunardi (ITA) W5.12.01 - DERAA directed T cells: a link between HLA-II association and rheumatoid arthritis Jurgen van Heemst, D. Jansen, M. Bax, A. Feitsma, M. Baarse, A. Moustakas, D. Bontrop-Elferink, G. Papadopoulos, T. Huizinga, R. Toes Leiden, Netherlands W5.12.05 - Endogenous SLPI controls B cell survival factor expression in TLR3-stimulated rheumatoid synovial fibroblasts Ngar W. Kam, F. Brentano, D. Kyburz, S. Gay, A. Filer, C. Buckley, C. Pitzalis, M. Bombardieri London, United Kingdom W5.02 - CHRONIC INFLAMMATION AND FIBROSIS W5.08.06 - Co-stimulatory signalling through lymphocyte CD40 limits adipose tissue inflammation and protects from de novo and pre-established metabolic disease in mice Dennis Wolf, F. Jehle, N. Bukosza, P. Aichele, N. Varo, C. Bode, P. Libby, K. Peter, A. Zirlik Freiburg, Germany IL5.12.02 - Role of soluble CD30/CD30L and of CD30/CD30L+ T cells in the modulation of inflammatory response in rheumatoid synovitis A. Barbieri, E. Tinazzi, A. Rigo, R. Gerli, G. Patuzzo, R. Beri, A. Puccetti, Claudio Lunardi Verona, Italy W5.12.04 - DNAse IgG activity in patients with early arthritis Marharyta Volkava, A. Kundzer, I. Generalov Vitebsk, Belarus W5.12.06 - In vivo RNAi mediated silencing of HNRNP-A2 decreases chronic inflammation by inhibiting proliferative and secretory capacity of monocytic cells Sonja Herman, J. Presumey, M. Koenders, W. van den Berg, F. Apparailley, G. Steiner Vienna, Austria W5.08.04 - A novel role for Rip2 in T cell regulation; Rip2 deficiency leads to increased Th17 skewing Kenichi Shimada, S. Chen, T. Crother, W. Zhang, M. Arditi Los Angeles, USA IL5.12.01 - Necrotizing autoimmune myopathy: emergence of a new autoimmune disease Olivier Boyer, L. Drouot, F. Jouen, Y. Allenbach, J. Charuel, L. Musset, I. Marie, O. Benveniste, &. French Myositis Network Rouen, France W5.12.03 - Antibodies from rheumatoid arthritis patients target citrullinated histone 4 contained in neutrophils extracellular traps F. Pratesi, I. Dioni, M. Alcaro, I. Paolini, F. Panza, I. Puxeddu, P. Rovero, Paola Migliorini Pisa, Italy W5.02.01 - Th-2 cytokine producing Tregs are present in the skin of patients with systemic sclerosis Raewyn Broady, J. Huang, K. MacDonald, J. Dunne, M.K. Levings Vancouver, Canada W5.02.02 - IL-33 precursor and bleomycin synergize in inducing lymphocyte accumulation and fibrosis in the lungs Irina G. Luzina, V. Lockatell, P. Kopach, N.W. Todd, S.P. Atamas Baltimore, USA W5.02.03 - A short-term model of COPD identifies a role for mast cell tryptase Phil M. Hansbro, E.L. Beckett, R.L. Stevens, A.G. Jarnicki, R.L. Kim, S. Keely, J.C. Horvat, P.A. Wark, B.G. Oliver, P.S. Foster Newcastle, Australia W5.02.04 - Suppressive role of neuroimmune semaphorin 4A in allergen-induced and VEGF-regulated lung inflammatory responses Svetlana P. Chapoval, E. Smith, E. Nkyimbeng-Takwi, K. Shanks, M.M. Lipsky, L.J. DeTolla, J.A. Elias, A.D. Keegan Baltimore, USA 35 16.45-18.15 SPACE 2 Workshops August 23, 2013 W5.02.05 - The condition of host CD4+CD25+ regulatory T cells determines the phenotype of autoimmune-like chronic GVHD Yuki Akieda, T. Nakamura, E. Wakamatsu, Y. Obata, S. Ogawa, S. Watanabe, R. Abe Chiba, Japan W1.13 - FC AND FC-LIKE RECEPTORS Chairs: Catherine Sautes Fridman (FRA) Jeanette H. Leusen (NLD) IL1.13.01 - Inside-out and outside-in Fc receptors: impact on antibody therapy of cancer Jeanette H.W. Leusen Utrecht, Netherlands W5.02.06 - Endogenous and immune cell derived BDNF supports regeneration in human skeletal muscle Emanuela Colombo, F. Bedogni, I. Lorenzetti, N. Landsberger, S.C. Previtali, C. Farina Milan, Italy IL1.13.02 - Fc gamma receptors: a 50 year anniversary Catherine Sautes Fridman Paris, France W1.13.01 - Role of IgG, IgG receptors and neutrophils in anaphylactic reactions Friederike Jönsson, D.A. Mancardi, P. Bruhns Paris, France W1.01 - GRANULOCYTES IL1.01.01 - Role of NADPH oxidase-derived reactive oxygen species in human neutrophil IL-1 beta secretion M.L. Gabelloni, F. Sabbione, C. Jancic, I. Keitelman, L. Iula, M. Oleastro, J. Geffner, Analia Trevani Buenos Aires, Argentina IL1.01.02 - Characterization of cytosolic proliferating cell nuclear antigen (PCNA) in neutrophils: anti-apoptotic role of the monomer A. De Chiara, Veronique Witko-Sarsat Paris, France 16.45-18.15 SPACE 4 Chairs: Veronique Witko-Sarsat (FRA) Analia Trevani (ARG) 16.45-18.15 SPACE 3 W1.01.01 - Chromatin configurations correlate with the differential capacity of human neutrophils and monocytes to express IL-6 in response to LPS Maili Zimmermann, N. Tamassia, M. Castellucci, M. Rossato, F. Bazzoni, M.A. Cassatella Verona, Italy W1.13.03 - Anti-inflammatory activity of IVIg mediated through the activating FcRIII (CD16) is induced by ITAMi signalling Sanae Ben Mkaddem, M. Aloulou, U. Blank, R.C. Monteiro Paris, France W1.13.04 - Antibody opsonised pathogens profoundly alter secondary immune responses through cross-talk of TLRs and FcRs Jantine Bakema, K. Tuk, S. van Vliet, S. Bruijns, J. Vos, S. Letsiou, C. Dijkstra, Y. van Kooyk, A. Brenkman, M. van Egmond Amsterdam, Netherlands W1.01.02 - Influence of CD137L signalling in myelopoiesis during acute and chronic inflammation Qianqiao Tang, D. Jiang, J.M.M. Gomez, S. Alonso, A. Pant, D.M. Kemeny, L. Chen, H. Schwarz Singapore, Singapore W1.13.05 - Monocytes rather than NK-cells contribute to antibody mediated protection from MCMV infection Anna Bootz, T. Winkler, M. Mach Erlangen, Germany W1.01.03 - Neutrophils have a negative impact on DC activation and disease progression following Leishmania major infection Steffen Schuster, B. Hurrell, D. Ashok, H. Acha-Orbea, F. Tacchini-Cottier Epalinges, Switzerland W1.13.06 - Swiprosin-1/EFhd2 is involved in the initial reaction of the IgE Fc receptor signal Yohei Mitsuhashi, M. Hachiya, T. Aradate, Y. Yamanoi, M. Kanamori, A. Muraguchi, D. Mietenz, T. Katagiri Toyama, Japan W1.01.04 - Novel neutrophil-T-Cell interactions: hormones and the regulation of T-Cell responses Suchita Nadkarni, F. Marelli-Berg, M. Perretti London, UK 36 W1.13.02 - Role of the phagocytic synapse in the recognition of bacteria and the subsequent induction of Th17-responses Marrit N. Habets, Z. Yang, H. elMoussaoui, M.I. de Jonge, D.A. Diavatopoulos Nijmegen, Netherlands W1.01.05 - Neutrophil Extracellular Trap formation in the pathogenesis of Staphylococcus aureus sepsis Elzbieta Kolaczkowska, P. Kubes Calgary, Canada W3.01 - LYMPHOID ORGANOGENESIS AND LINEAGE COMMITMENT W1.01.06 - Activated basophils form extracellular DNA traps able to kill bacteria Mahbubul Morshed, D. Simon, T. Kaufmann, R. Hlushchuk, V. Djonov, H. Simon, S. Yousefi Bern, Switzerland IL3.01.01 - TNF and both soluble and membranebound lymphotoxins have distinct functions in GALT organogenesis and in intestinal immunity A.A. Kruglov, Sergei A. Nedospasov Berlin, Germany 16.45-18.15 AMBER 1+2 Chairs: Sergei Nedospasov (RUS) Matthew F. Krummel (USA) W3.01.01 - The layered immune system: adult hematopoietic stem cells cannot fully reconstitute all of the functionally distinct immune cell subsets Eliver E.B. Ghosn, R. Yamamoto, S. Hamanaka, Y. Yang, L. Herzenberg, H. Nakauchi, L. Herzenberg Stanford, USA Workshops August 23, 2013 W6.03 - PATHOGENESIS AND IMMUNOINTERVENTION IN DIABETES W3.01.02 - Deletion of the atypical chemokine receptor CCX-CKR alters thymic stroma, impairs thymocyte development and promotes autoimmunity Shaun R. McColl, M. Bunting, N. Seach, M. Hammett, D.L. Asquith, H. Korner, R.L. Boyd, R.J.B. Nibbs, I. Comerford Adelaide, Australia Chairs: Piero Marchetti (ITA) Leonard Harrison (AUS) IL6.03.01 - Soluble CD52 released by activated T cells interacts with Siglec-10 to suppress T cell activation and prevent autoimmune disease E. Bandala-Sanchez, Y. Zhang, S. Reinwald, J.A. Dromey, B. Lee, J. Qian, R.M. Boehmer, Leonard C. Harrison; Parkville, Australia 16.45-18.15 AMBER 1+2 W3.01.03 - Identification of thymic epithelial stem cells ensuring lifelong central T cell tolerance Miho Sekai, Y. Hamazaki, N. Minato Kyoto, Japan W3.01.04 - Dissecting the cellular and molecular requirement for Lymphotoxin in orchestrating B cell accumulation in ectopic follicle like structures in a rodent model of multiple sclerosis Natalia Pikor, G. Galicia, D. Ng, J. Gommerman Toronto, Canada W6.03.01 - Detection of Chromogranin A-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse Niyun Jin, F. Crawford, J. White, M. Philippa, J. Kappler Denver, USA W6.03.02 - IL-21 is a critical regulator of chronic/persistent but not acute/accelerated auto-immune and alloimmune responses Mithun Khattar, P. Schroder, C. Baum, R. Deng, W. Chen, S. Stepkowski Toledo, USA W3.01.05 - Pbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors Francesca Ficara, L. Crisafulli, C. Lin, M. Iwasaki, L. Zammataro, M.L. Cleary Milan, Italy W6.03.03 - Postnatal events in intestinal gene expression and splenic cell composition is altered in NOD mice Dina S.M. Damlund, S. Metzdorff, M.B. Kristensen, A.K. Hansen, K. Buschard, H. Frøkiær Frederiksberg, Denmark W1.17 - ALLERGIC MEDIATORS Chairs: Massimo Triggiani (ITA) Annika Scheynius (SWE) W1.17.01 - Novel regulatory control of IgE antibody responses in vivo Danyal Butt, T. Chan, R. Brink Sydney, Australia 16.45-18.15 AMBER 7+8 W1.17.02 - Basophil-derived mouse mast cell protease 11 is involved in the development of IgE-mediated chronic allergic inflammation Hayato Deki, Y. Kawano, S. Yoshikawa, M. Iki, M. Egawa, T. Ohta, H. Karasuyama Tokyo, Japan W1.17.03 - Analysis of NK cell subsets in children with atopic dermatitis Gunnur Deniz, E. Aktas Cetin, N. Akdeniz, B. Safa, M. Kosker, Y. Camcioglu, &. Barlan Istanbul, Turkey 16.45-18.15 BROWN 2 W3.01.06 - Survivin inhibition disturbs Bcl-6 and Blimp-1 control of lymphocyte differentiation Maria Bokarewa, S. Andersson, M.N. Svensson, M. Erlandsson, I. Jonsson, K.M. Andersson Göteborg, Sweden W6.03.04 - Antigen-specific protection against highly aggressive cytotoxic T cells in diabetes by intradermal injection of heme-oxygenase-1 inducer Thomas Simon, J. Pogu, S. Pogu, J. Bach, S. Remy, E. Piaggio, I. Anegon, P. Blancou Nantes, France W6.03.05 - Inhibiting Th17 cells and reducing insulitis in diabetic NOD mice by GW9508, a GPR40 and GRP120 dual agonist Zhiguang Guo, A. Ansarullah, Y. Lu, M. Holstein, B. Deruyter Sioux Falls, USA W6.03.06 - New insights into type 1 diabetes development and therapy Christopher R. Parish, A.F. Ziolkowski, Z. Wu, S.K. Popp, C. Freeman, C.J. Simeonovic Canberra, Australia W1.17.04 - Novel IL-9-producing innate helper cells promote oral antigen-induced anaphylaxis Yui-Hsi Wang, C. Chen, J. Lee, B. Liu, F. Finkelman, S. Hogan Cincinnati, USA W1.17.05 - Lack of PTX3 enhanced airway inflammation and hyperresponsiveness in a murine model of asthma J. Balhara, L. Shan, Abdelilah Soussi-Gounni Winnipeg, Canada W1.17.06 - MicroRNA-155 augments local Th2 response in a mouse model of allergic airway inflammation Carina Malmhäll, S. Alawieh, Y. Lu, M. Sjöstrand, A. Bossios, M. Eldh, M. Rådinger Gothenburg, Sweden 37 Chair: Jeffrey A. Bluestone (USA) Marc Feldmann (GBR) Beyond anti-TNF therapy for rheumatoid arthritis: can we get close to a cure? PS.04 - PERSPECTIVES IN IMMUNOLOGY Chair: Tak W. Mak (CAN) Philippa Marrack (USA) T cell receptors, their specificity and role in selection PL.03 - PLENARY LECTURE Chair: Alberto Mantovani (ITA) Charles A. Dinarello (USA) Blocking IL-1 to treat inflammatory conditions LL.10 - LUNCHTIME LECTURE Chair: Ruslan Medzhitov (USA) Visnva Dixit (USA) Recent progress in understanding inflammasome biology LL.12 - LUNCHTIME LECTURE Chair: Ellis Reinherz (USA) Tak W. Mak (CAN) The four horsemen of anti-apocalypse 12.30 - 13.15 BROWN 3 LL.08 - LUNCHTIME LECTURE 12.30 - 13.15 SPACE 1+2 Chair: Peter C. Doherty (AUS) Stefan H.E. Kaufmann (DEU) On immunity in, biomarkers for, and vaccines against tuberculosis 12.30 - 13.15 SPACE 4 12.30 - 13.15 GOLD ROOM 12.30 - 13.15 BROWN 1+2 12.30 - 13.15 SPACE 3 LL.09 - LUNCHTIME LECTURE Chair: Angela Santoni (ITA) Marco Colonna (USA) Innate lymphoid cells in mucosal immunity LL.11 - LUNCHTIME LECTURE Chair: Peter Cresswell (USA) Tasuku Honjo (JPN) Molecular mechanism for antibody memory generation LL.13 - LUNCHTIME LECTURE with the contribution of STEMCELL Technologies Inc. Chair: Cyrus Eduljee (CAN) Norberto Zwirner (ARG) Cytokine regulation of natural killer cell effector functions LL.14 - LUNCHTIME LECTURE Chair: Arlene Sharpe (USA) Bernard Malissen (FRA) Toward an integrative biology of T cells and dendritic cells 18.30 - 19.15 GOLD ROOM 12.30 - 13.15 AMBER 1+2 38 8.50 - 9.20 SPACE 1+2 PS.03 - PERSPECTIVES IN IMMUNOLOGY 9.30 - 10.15 GOLD ROOM 8.50 - 9.20 GOLD ROOM Main Lectures August 24, 2013 PL.04 - PLENARY LECTURE Chair: Siamon Gordon (GBR) Alberto Mantovani (ITA) Interactions between the cellular and the humoral arm of innate immunity S7 - CANCER IMMUNOTHERAPY S8 - INNATE IMMUNE SENSORS Chairs: Paola Zanovello (ITA) Gunter Hammerling (DEU) Olja J. Finn (USA) S7.01 Cancer immunosurveillance and immunoprevention James P. Allison (USA) S7.02 Mobilizing the immune system to treat cancer: new insights and opportunities Cornelis Melief (NLD) S7.03 TLR-ligand peptide conjugates for superior therapeutic vaccination against immunogenic cancers Andrea Velardi (ITA) S7.04 Harnessing immunity to leukemia and infections after haploidentical hematopoietic transplantation Drew M. Pardoll (USA) S7.05 Establishment of immunotherapy as the fifth pillar of cancer treatment Chairs: Jerrold P. Weiss (USA) Mohammed Daha (NLD) Caetano Reis e Sousa (GBR) S8.01 Dendritic cells as innate immune sensors Maya Saleh (CAN) S8.02 NLRs and inflammasomes in intestinal homeostasis, cancer and me Alessandro Moretta (ITA) S8.03 Human NK cell receptors and pathogen infection Peter Parham (USA) S8.04 Variable natural killer cell receptors and human evolution David H. Raulet (USA) S8.05 NK receptors in immune surveillance and inflammation 10.20 - 12.25 SPACE 1+2 10.20 - 12.25 GOLD ROOM Parallel Symposia August 24, 2013 10.20 - 12.25 BROWN 3 Chairs: Peter D. Katsikis (USA) Lionel B. Ivashkiv (USA) Gioacchino Natoli (ITA) S9.01 A genomic framework for macrophage identity and functional specialization Alexander Tarakhovsky (USA) S9.02 The control of the antiviral innate response by histone mimics Luke O’Neill (IRL) S9.03 Metabolism, epigenetics and miRNAs: an unholy trinity controlling innate immunity Sergio Abrignani (ITA) S9.04 Regulation of T lymphocyte effector functions by non-coding RNAs Warren J. Leonard (USA) S9.05 The c family of cytokines: from human disease to transcriptional regulation S10 - T AND B CELL REPERTOIRES Chairs: Mitzi Nagarkatti (USA) Fritz Melchers (DEU) Yousuke Takahama (JPN) S10.01 The thymic microenvironments that shape T cell repertoire Michael B. Brenner (USA) S10.02 iNKT T cells: innate lipid sensing T cells regulate inflammation Meinrad Busslinger (AUT) S10.03 Transcriptional control of early B cell development Frederick W. Alt (USA) S10.04 Long range elements that control mouse and human IgH V(D)J recombination and repertoires Michel C. Nussenzweig (USA) S10.05 The human antibody response to HIV S11 - VIRAL INFECTIONS S12 - IMMUNODEFICIENCIES Chairs: Mario Clerici (ITA) Elopy Sibanda (ZBW) Stipan Jonjic (HRV) S11.01 Viral regulation of inhibitory and activating Ly49 receptors Vincenzo Barnaba (ITA) S11.02 Viral infections, autoimmunity and immunoregulation Christine A. Biron (USA) S11.03 Cytokine regulation of NK and CD8 T cell responses to acute viral infections Giuseppe Pantaleo (CHE) S11.04 Role of T follicular helper cells in HIV infection Bruce D. Walker (USA) S11.05 T cell control of HIV Chairs: Ridha Barbouche (TUN) Anna Villa (ITA) Steven M. Holland (USA) S12.01 GATA2 deficiency: one gene, many manifestations Jean-Laurent Casanova (USA) S12.02 Toward a genetic theory of childhood infectious diseases Bodo Grimbacher (GBR) S12.03 How Satan smote job: a novel genetic defect causing hyper IgE Syndrome Anne Durandy (FRA) S12.04 Molecular and functional delineation of human inherited immunoglobulin class switch recombination deficiencies Luigi Notarangelo (USA) S12.05 Modeling primary Immune deficiencies with patient-derived induced pluripotent stem cells 10.20 - 12.25 SPACE 4 10.20 - 12.25 SPACE 3 10.20 - 12.25 BROWN 1+2 S9 - GENETIC AND EPIGENETIC CONTROL 39 Sponsored Sessions August 24, 2013 INTRAVENOUS IMMUNOGLOBULINS IN ANTIBODY DEFICIENCIES AND AUTOIMMUNE DISEASES 13.30 - 15.00 SPACE 3 with the contribution of Biotest Chair: Peter Hans-Hartmut (DEU) Peter Hans-Hartmut (DEU) Immunoglobulins in primary immunodeficiencies Krivan Gergely (HUN) Tolerability and safety of a new 10% intravenous immunoglobulin in patients with primary immunodeficiencies Stangel Martin (DEU) Treatment of immune neuropathies with IVIG INFECTIOUS AGENTS AND AUTOIMMUNITY - PART I with the contribution of Italian Ministry of Health and Italian Multiple Sclerosis Foundation 13.30 - 15.00 SPACE 4 Project grant n. GR-2010-2313255 R. Mangozzi Chairs: Francesca Aloisi (ITA) - Christian Münz (CHE) Francesca Aloisi (ITA) New emphasis on host-pathogen interactions in autoimmune diseases Jean-Laurent Casanova (USA) Human genetics of infectious diseases Matthias von Herrath (USA) Viruses and type-1 diabetes Eicke Latz (DEU) Role of inflammasomes for chronic inflammatory diseases 40 Workshops August 24, 2013 W6.06 - CANCER IMMUNOTHERAPY AND ANTITUMOR VACCINES W6.06.09 - Exploiting the good and blocking the bad: new strategies to convert the tumor into an in situ personalized vaccine C. Vanpouille-Box, K.A. Pilones, M.L. Dustin, M.H. Barcellos-Hoff, S.C. Formenti, Sandra Demaria New York, USA Chairs: Shimon Slavin (ISR) Giorgio Parmiani (ITA) IL6.06.01 - Cell therapy of cancer with alloreactive intentionally mismatched IL-2 activated donor lymphocytes targeting anti-cancer killer NK & T cells using monoclonal and bispecific antibodies Shimon Slavin, C. Brodie Tel Aviv, Israel W6.06.02 - Synergistic 4-1BB and CD28 costimulation enables CD19-targeted T cells to eliminate aggressive leukemia, in an IRF7-dependent manner Maud Condomines, Z. Zhao, C. Kloss, M. Sadelain New York, USA 15.10-18.15 GOLD ROOM W6.06.01 - Examination of cancer testis antibodies and Th1/Th2 cytokines as prognosis markers in glioma patients treated with Delta-24-RGD oncolytic adenovirus Juan Fueyo, F. Lang, C. Gomez-Manzano, A. Yung, R. Sawaya, C. Conrad Houston, USA W6.06.10 - A new class of iNKT cell agonist to harness tumor immunity M. Terabe, J.J. O’Konek, S. Kato, S. Takao, L. Izhak, Z. Xia, P. Illarinov, G. Besra, Jay A. Berzofsky Bethesda, USA W6.06.04 - Regeneration of human melanoma antigen-specific T cells from iPSCs derived from mature CD8+ T cells Raul Vizcardo, K. Masuda, D. Yamada, T. Ikawa, K. Shimizu, S. Fujii, H. Koseki, H. Kawamoto Yokohama, Japan W6.06.14 - Entire requirement of endogenous type I interferon for the efficacious cancer treatment with viral vector-encoded IL-12 Sandra Hervas-Stubbs, J.I. Quetglas, U. Mancheño, E. Casales, J.I. Riezu-Boj, M.C. Ochoa, M.F. Sanmamed, N. Thieblemont, C. Smerdou, I. Melero Pamplona, Spain W6.06.05 - Isolation of antigen-specific TCR genes and analysis of disease-associated TCR repertoires by TCR gene capture Carsten Linnemann, B. Heemskerk, P. Kvistborg, R.J.C. Kluin, D.A. Bolotin, R.M. Kerkhoven, M. Nieuwland, D.M. Chudakov, G.M. Bendle, T.N.M. Schumacher Amsterdam, Netherlands W4.01 - IMMUNITY TO VIRUS INFECTION Chairs: Ahmed El-Gohary (EGY) Margarida Souto-Carneiro (PRT) W6.06.06 - Glycoengineered defucosylated anti-CD20 antibodies activate neutrophils-mediated phagocytosis more efficiently than rituximab Josée Golay, F. Da Roit, L. Bologna, C. Ferrara, J.H. Leusen, A. Rambaldi, C. Klein, M. Introna Bergamo, Italy W6.06.07 - FOXO3 regulates tumor-associated dendritic cell tolerogenicity by binding and sequestering NF-B Stephanie K. Watkins, A.A. Hurwitz Maywood, USA W6.06.08 - Host immunity contributes to the anti-melanoma activity of BRAF inhibitors Shin Foong Ngiow, D.A. Knight, M. Li, T. Parmenter, N.M. Haynes, K. Kinross, H. Yagita, A. Ribas, G.A. McArthur, M.J. Smyth Melbourne, Australia W6.06.12 - Conditioning tumor microenvironments for effective entry and function of effector T cells Pawel Kalinski, R. Muthuswamy, N. Obermajer, H.J. Zeh, A. Zureikat, K. Odunsi, R. Edwards, D. Bartlett Pittsburgh, USA W6.06.13 - A bi-institutional pilot study of peptidebased vaccines in combination with poly ICLC in patients with WHO grade 2 low-grade glioma Hideho Okada, L.H. Butterfield, R.L. Hamilton, M.O. Lively, M.D. Chan, A.M. Salazar, D.M. Potter, E.G. Shaw, F.S. Lieberman Pittsburgh, USA IL4.01.01 - Genomic polymorphisms in 3-hydroxysterol 24-reductase promoter sequences N.E. Salem, M. Saito, Y. Kasama, M. Ozawa, T. Kawabata, S. Harada, H. Suda, K. Asonuma, Ahmed El-Gohary, K.T. Kohara Ismailia, Egypt 15.10-18.15 BROWN 3 15.10-18.15 GOLD ROOM W6.06.03 - Development of a tumor stem cell specific T-cell engaging antibody for the treatment of glioblastoma multiforme S. Prasad, S. Gaedicke, M. Hettich, E. Firat, X. Zhu, K. Klingner, J. Schüler, Gabriele Niedermann Freiburg, Germany W6.06.11 - Naive-derived memory stem T cells: a novel promising platform for cancer immune-gene therapy Nicoletta Cieri, B. Camisa, F. Cocchiarella, M. Forcato, G. Oliveira, E. Provasi, A. Bondanza, F. Mavilio, A. Mondino, C. Bonini Milan, Italy W4.01.01 - Suppressor of cytokine signalling (SOCS) 4 is a critical regulator of the anti-viral immune response Lukasz Kedzierski, E. Linossi, N. Bird, B. Day, T. Kolesnik, G. Belz, B. Kile, N. Nicola, K. Kedzierska, S. Nicholson Parkville, Australia W4.01.02 - Timing and quality of the type-I interferon response to viral infection is tuned by stochastic cellular decisions at multiple levels Ulfert Rand, M. Rinas, J. Schwerk, H. Hauser, D. Spiller, P. Paszek, M.R.H. White, T. Höfer, M. Köster Manchester, United Kingdom 41 W4.01.03 - Serological diagnosis of Pepino mosaic virus with new generated monoclonal antibodies Amal Souiri, M.M. Ennaji, H. Laatiris, S. Amzazi, M. Zemzami Casablanca, Morocco W4.01.04 - An identical microRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination Yoav Bauman, O. Mandelboim Jerusalem, Israel 15.10-18.15 BROWN 3 Workshops August 24, 2013 W4.01.05 - CD4+ T cells modulate Epstein-Barr virus latency types Noemi Nagy, F. Heuts, D. Salamon, M. Adori, A.E. Rasul, H.S. Madapura, M. Rottenberg, G. Klein, E. Klein Stockholm, Sweden Chairs: Martin Olivier (CAN) Peter Sebo (CZE) IL4.04.01 - Lesson from Leishmania Infection to Combat Bacterial-Mediated Inflammatory Response Martin Olivier Montréal, Canada W4.01.08 - Dual deletion of type I and type II interferon-binding proteins in NYVAC-HIV-1 Env-Gag-PolNef poxvirus vaccine vectors markedly improves vector immunogenicity Julie Delaloye, A. Filali-Mouhim, M. Cameron, E. Haddad, M. Esteban, G. Pantaleo, T. Roger, R. Sékaly, T. Calandra Lausanne, Switzerland W4.01.11 - Chronic viral infection alters subnuclear localization of PD-1 and L-selectin loci linked to transcriptional programming in LCMV-specific CD8 T-cells Catarina Sacristan, B.A. Youngblood, J.X. Xu, P. Lu, K. McGary, S.L. Hewitt, J.A. Skok, J.M. Boss, R. Ahmed, M.L. Dustin New York, USA W4.01.12 - The anti-apoptotic protein Mcl-1 is essential for the CD8 T cell response upon chronic viral LCMV infection Eleonora Ottina, S.P. Preston, A. Strasser, M. Pellegrini, A. Villunger Innsbruck, Austria 42 IL4.04.02 - Fooling phagocytes and delivering T cell vaccines: The ‘yin and yang’ of Bordetella adenylate cyclase toxin Peter Sebo Prague, Czech Republic W4.04.01 - Orchestration of inflammation and adaptive immunity in Borrelia burgdorferi-induced arthritis by NapA Gaia Codolo, F. Bossi, P. Durigutto, M.M. D’Elios, M.A. Cassatella, M. de Bernard Padua, Italy 15.10-16.40 SPACE 1 15.10-18.15 BROWN 3 W4.01.07 - Evolution of neutralizing antibodies against HIV-1C gp160 molecular envelope clones from acute heterosexually acquired HIV-1C infections in Botswana Takafira Mduluza, K. Bedi, S. Dzoro, W. Mpoloka, R. Musonda Harare, Zimbabwe W4.01.10 - Molecular characterization of immunoglobulin (Ig) genes reveals that plasmablasts generated during heterologous secondary dengue infections and circulating memory B cells after recovery are of distinct origin Ramapraba Appanna, M.H. Xu, V. Hadinoto, K. Joensson, Y.X. Toh, T. Balakrishnan, Y.S. Leo, C. Wang, K. Fink Singapore, Singapore W4.01.14 - Spred-2 deficiency exacebates Influenza A Virus (H1N1)-induced pneumonia Toshihiro Ito, A. Yoshimura, A. Matsukawa Okayama, Japan W4.04 - IMMUNITY TO BACTERIAL INFECTION (EXCLUDING MYCOBACTERIA) W4.01.06 - HSV-2 regulates inflammatory response in the vaginal epithelium via the Fas/FasL pathway Malgorzata Krzyzowska, P. Orlowski, W. Stankiewicz Warsaw, Poland W4.01.09 - A novel mechanism of HTLV-1-associated mylopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis Abbas Pishdadian, J. Tavakkol Afshari, M. Foroughi Poor, A. Zamani Mashhad, Islamic Republic of Iran W4.01.13 - Pregnancy-induced deviation of chemokine/cytokine serological levels during influenza virus AH1N1 infection Luis A. Flores-Mejía, I. Mancilla-Herrera, E.D. Cerezo, A. Cérbulo-Vázquez, E. Ferat-Osorio, C.R. López-Macías, A. Isibasi, L.A. Arriaga-Pizano México City, Mexico W4.04.02 - Imaging Bacillus anthracis edema toxin effects on normalized murine dendritic cells and macrophages Yannick Trescos, D. Fiole, M. Mulier, J.N. Tournier La Tronche, France W4.04.03 - Role for coagulation factor XI during pneumococcal pneumonia independent of factor XII activation. Ingrid Stroo, C. van ‘t Veer, J.J.T.H. Roelofs, J.C.M. Meijers, F.J. Castellino, S. Zeerleder, T. van der Poll Amsterdam, Netherlands W4.04.04 - The macrophage serves as a gate-keeper for the induction of protective host immunity and bacterial dissemination during Chlamydia infection Eric Gracey, Y. Baglaenko, A. Lin, A. Akram, R.D. Inman Toronto, Canada W4.04.05 - B cells participate on the early stages of immune response against intracellular bacterial pathogen Francisella tularensis Zuzana Krocova, K. Kubelkova, L. Plzakova, L. Zarybnicka, Z. Sinkorova, A. Macela Hradec Kralove, Czech Republic W4.04.06 - Immune evasion in Leptospira: the secretion of proteases that cleave complement proteins Tatiana R. Fraga, D.S. Courrol, M.M. Castiblanco-Valência, I.Y. Irata, L. Juliano, S.A. Vasconcellos, A.S. Barbosa, L. Isaac São Paulo, Brazil Workshops August 24, 2013 W5.09 - NEUROIMMUNOLOGY W6.16.04 - Fractalkine ligand-receptor axis dictates prognostic outcome in human colorectal cancer Marco Erreni, I. Siddiqui, F. Marchesi, S. Pesce, D. Morone, A. Doni, C. Rumio, L. Laghi, A. Mantovani, P. Allavena Milan, Italy IL5.09.01 - EBV specific CD8+ T cells in Multiple Sclerosis Luca Battistini Rome, Italy W5.09.01 - Regulatory T cells together with resolving macrophages orchestrated by Th1 cells are non-redundant pivotal players in CNS repair Catarina Raposo, M. Schwartz Rehovot, Israel 15.10-16.40 SPACE 3 Chairs: Luca Battistini (ITA) Michal Schwartz (ISR) W6.16.06 - Unique TCR signature of a novel cross-reactive CMV-specific T cell receptor: Potential clinical implications Nicole A. Mifsud, T.H.O. Nguyen, L. Rowntree, N. Bird, D. Pellicci, K. Kedzierska, T. Kotsimbos Melbourne, Australia W5.09.03 - IL-33/ST2 axis mediates resistance to EAE by promoting regulatory B and tolerogenic dendritic cells Marija Z. Milovanovic, A.N. Arsenijevic, J.Z. Milovanovic, B. Stojanovic, N.N. Arsenijevic, M.L. Lukic Kragujevac, Serbia W3.07 - B CELL DEVELOPMENT AND PLASMA CELL DIFFERENTIATION W5.09.04 - N-methyl-D-aspartate receptor (NMDAR) antibodies in post Herpes Simplex virus encephalitis neurological relapse Yael Hacohen, K. Deiva, P. Pettingill, P. Waters, P. Chretien, E. Menson, e. Lin, M. Tardieu, A. Vincent, M. Lim Oxford, United Kingdom W3.07.01 - The Ras/Erk/PI3K pathways during positive selection of primary B cells Chiara Babolin, L. Sinik-Teodorovic, R. Torres, R. Pelanda Denver, USA Chairs: Majorie A. Oettinger (USA) Hedda Wardemann (DEU) W5.09.05 - Neuroimmunological changes in the Cstb-/mouse: a model for progressive myoclonus epilepsy Olesya Okuneva, Z. Li, I. Körber, L. Tian, T. Joensuu, A. Lehesjoki, O. Kopra Helsinki, Finland W3.07.02 - Characterization of umbilical cord blood CD34+CD43+CD19+CD38lo/int cells suggests a common progenitor for human B1 and B2 cells Tam D. Quach, N.E. Holodick, R. Vuyyuru, T. Manser, T.L. Rothstein Manhasset, USA W5.09.06 - Elucidation of pathogenic mechanism of myasthenia gravis with MuSK antibodies using a novel murine model M. Shuuichi, S. Kubo, M. Kishi, T. Konishi, Kazuhiro Shigemoto Tokyo, Japan W3.07.03 - A human marginal zone B cell precursor Marc Descatoire, S. Weller, S. Irtan, J.C. Weill, C.A. Reynaud Paris, France W6.16 - BIOMARKERS AND CLINICAL PROFILING OF HUMAN IMMUNE RESPONSES Chairs: Armando Gabrielli (ITA) Carlo Selmi (ITA) W6.16.01 - An autoantibody profile for SLE diagnosis using the ImmunArray iCHIPTM Irun R. Cohen, V. Daniel Carmi, L. Belanis-Meirovich, R. Sorek, O. Cohen-Gindi, N. Dromi, M. Lerner, E. Sahar, I. Tamir, C. Putterman Rehovot, Israel W6.16.02 - Identification of potential biomarkers and therapeutic targets for multiple sclerosis by M2 proteomics Itay Raphael, W.E. Haskins, T.G. Forsthuber San Antonio, USA 15.10-16.40 SPACE 4 15.10-16.40 SPACE 2 W5.09.02 - Triggers of anti-CNS autoimmunity in mouse model of multiple sclerosis Pushpalatha Palle, T. Buch Munich, Germany 15.10-16.40 SPACE 3 W6.16.05 - Tumor-specific adaptive immune responses to primary and metastatic ovarian tumors C.L. Desmarais, R. Emerson, A. Sherwood, C. Sanders, M. Tewari, J. Guenthoer, C. Carlson, C. Drescher, Harlan Robins Seattle, USA W3.07.04 - The ELL-associated factor 2 negatively regulates germinal center B cell survival and humoral immune responses Yingqian Li, Y. Takahashi, S. Fujii, J. Wang Yokohama, Japan W3.07.05 - Epstein-Barr virus-encoded latent membrane protein 2A impairs B cell selection in germinal centers but not germinal center formation Takeharu Minamitani, S. Sakakibara, T. Yasui, H. Kikutani Suita, Japan W3.07.06 - IgE-expressing B cells are restrained by an intrinsic cell fate predisposition Zhiyong Yang, C.D.C. Allen San Francisco, USA W6.16.03 - The alarmins S100A8 and S100A9 as promising targets for non-invasive molecular imaging of phagocyte activation during inflammation Tom Völler, M. Eisenblätter, J. Roth, T. Vogl Münster, Germany 43 Workshops August 24, 2013 W5.22 - PRIMARY IMMUNODEFICIENCIES W6.01.02 - Effects of w3 fatty acid in experimental model of mucositis induced by 5-FU Tatiani U. Maioli, B. Melo, M. Nobre, M.C. Oliveira, N.C.N. Paiva, V.N. Cardoso, A.C. Faria, A.V.M. Ferreira, C.M. Carneiro, S.V. Generoso Belo Horizonte, Brazil Chairs: Raffaele Badolato (ITA) Capucine Picard (FRA) 15.10-16.40 AMBER 1+2 W5.22.02 - A new form of global leucopenia associated with mutation in the moesin gene Chantal Lagresle-Peyrou, F. Ouchani, S. Luce, J. Stephan, C. Hivroz, G. De Saint Basile, A. Fischer, N. Jabado, M. Cavazzana-Calvo, I. André-Schmutz Paris, France W5.22.03 - Critical role of DOCK8 in dendritic cell trafficking during T cell immune responses Akira Shiraishi, Y. Tanaka, Y. Fukui Fukuoka, Japan 15.10-16.40 AMBER 3+4 W5.22.01 - Mucosal immune dysregulation in Omenn syndrome Barbara Cassani, V. Maina, V. Marrella, F. Grassi, J.R. Mora, A. Villa Milan, Italy W6.01.04 - Hepatocyte nuclear factor 4 alpha regulates immune cell activation and autoimmunity Marco Di Dario, E. Colombo, C. Farina Milan, Italy W5.22.04 - Investigating T cell subsets in DOCK8 immunodeficiency Katrina L. Randall, H.D. Law, C.C. Goodnow Woden, Australia W6.01.05 - Mast cell protease expression is reduced in vitro and in vivo in response to cinnamon treatment Yvonne Hagenlocher, I. Bergheim, S.C. Bischoff, A. Lorentz Stuttgart, Germany W5.22.05 - Resolving the heterogeneity of common variable immune deficiency by exome sequencing and deep phenotyping Matthew C. Cook, J. Al Shekaili, C. Lee, B. Whittle, D. Andrews, C. Vinuesa, C. Goodnow, D. Fulcher Canberra, Australia W6.01.06 - Immunomodulatory effects and antitumor activities of conjugated linolenic acids on the murine macrophage-like leukemia cells KN Leung, W. Liu Hong Kong, China W5.22.06 - Altered B and T lymphocyte homeostasis in the bone marrow and the periphery correlates with clinical findings in common variable immunodeficiency Vassilios Lougaris, M. Baronio, M. Vitali, S. Masneri, K. Cattivelli, G. Tampella, D. Moratto, A. Soresina, R. Badolato, A. Plebani Brescia, Italy W3.12 - FOLLICULAR HELPER T CELLS Chairs: Cecile King (AUS) Teresa Marafioti (GBR) IL3.12.01 - Interleukin-21 directs T follicular helper cell differentiation A. Vogelzang, H. McGuire, S. Liu, Cecile King Darlinghurst, Australia W6.01 - IMMUNOMODULATION BY NUTRIENTS AND VITAMINS IL6.01.01 - Stopping T cells in their tracks, vitamin D suppresses naïve CD8 T cell proliferation Margherita T. Cantorna, J. Chen, D. Bruce University Park, United States IL6.01.02 - Vitamin D regulates complement receptor immunoglobulin (CRIg) expression in human macrophages Antonio Ferrante Adelaide, Australia W6.01.01 - Immunomodulatory role of vitamin D in allergic airway inflammation and airway hyperresponsiveness in bronchial asthma Devendra K. Agrawal, T. Agrawal, G.K. Gupta Omaha, USA 15.10-16.40 AMBER 5+6 Chairs: Margherita Cantorna (USA) Antonio Ferrante (AUS) 15.10-16.40 AMBER 3+4 W6.01.03 - The Agaricus blazed-based mushroom extract, AndosanTM, has immuno- suppressive and antiinflammatory effects when used as supplement to multiple myeloma patients receiving high-dose chemotherapy and autologous bone marrow transplantation Geir Hetland, J. Tangen, A. Tierens, G. Kvalheim, L. Osnes, G. Tjønnfjord Oslo, Norway W3.12.01 - Functional overlap of ROQUIN-1 and ROQUIN-2 in the repression of mRNAs controlling Tfh cell accumulation and systemic inflammation A. Pratama, R.R. Ramiscal, D.G. Silva, S. Das, Vicki Athanasopoulos, X. Hu, J.J. Hogan, C. Goodnow, M. Cook, C.G. Vinuesa Canberra, Australia W3.12.02 - Identification of human Tfh-specific microRNAs and investigation of their role in Tfh differentiation and function A. Ripamonti, Elena Provasi, G. Rossetti, S. Curti, V. Ranzani, V. Parente, F. Facciotti, M. Moro, S. Abrignani, M. Pagani Milan, Italy W3.12.03 - Follicular regulatory T cells migrate to germinal centers via NFAT2-mediated signalling M. Vaeth, G. Mueller, D. Stauss, L. Dietz, S. Klein-Hessling, E. Serfling, M. Lipp, I. Berberich, Friederike BerberichSiebelt Wuerzburg, Germany W3.12.04 - The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut Shimpei Kawamoto, T.H. Tran, M. Maruya, K. Suzuki, Y. Doi, Y. Tsutsui, L.M. Kato, S. Fagarasan Yokohama, Japan 44 W3.12.05 - Regulation of T helper cell-dependent antibody response in lymphopenic hosts Silvia Preite, D. Baumjohann, F. Ronchi, F. Sallusto, A. Lanzavecchia Bellinzona, Switzerland W3.12.06 - Fate decision of germinal centre B cells is based on asymmetric division Michael Meyer-Hermann, Y. Zhang, G.D. Victora, K. Toellner Braunschweig, Germany W2.04 - MICRORNAS IN IMMUNE REGULATION Chairs: Hans-Martin Jack (DEU) Flavia Bazzoni (ITA) W2.04.01 - TCD8+ suppressor cells produce antigenspecific exosomes carrying microRNA-150 to inhibit contact sensitivity response K. Bryniarski, Katarzyna Nazimek, E. Sikora, M. Ptak, P.W. Askenase, W. Ptak Krakow, Poland 15.10-16.40 AMBER 7+8 W2.02.02 - Estradiol promotes functional responses in inflammatory and steady state dendritic cells through differential requirement of activation function-1 of estrogen receptor Sophie Laffont, C. Seillet, N. Rouquié, A. Krust, P. Chambon, J. Arnal, J. Guéry Toulouse, France W2.02.03 - Identification of TREM-1 as a novel target of nuclear receptor ligands in dendritic cells Raffaella Fontana, N. Di Meglio, C. Battaglia, M. Mattioli, M. Cella, C. Doglioni, C. Traversari, M. Colonna, V. Russo Milan, Italy 15.10-16.40 BROWN 1 15.10-16.40 AMBER 5+6 Workshops August 24, 2013 W2.04.03 - Investigating the impact of individual miRNAs on Treg conversion Sebastian C. Warth, A. Hiekel, V. Heissmeyer Munich, Germany W4.05 - IMMUNITY TO MYCOBACTERIAL INFECTION W2.04.04 - IL-10-induced microRNA-187 negatively regulates TNF, IL-6 and IL-12p40 production in TLR4stimulated monocytes Marzia Rossato, G. Curtale, N. Tamassia, M. Castellucci, L. Mori, S. Gasperini, B. Mariotti, M.A. Cassatella, M. Locati, F. Bazzoni Verona, Italy Chairs: Anca Dorhoi (DEU) Harriet Mayanja-Kizza (UGA) IL4.05.01 - Ex vivo chemokines and cytokines measrurements as biological markers in the immuno-diagnosis of active pulmonary tuberculosis Harriet Mayanja-Kizza, A. Namuganga, M. Nsereko, G. Muzanye, J. Baseke, P. Peters Kampala, Uganda, Uganda 15.10-16.40 BROWN 1 Chairs: Cosima Baldari (ITA) Antonio Moschetta (ITA) IL2.02.01 - Modulation of TCR signaling and T cell activation by glucocorticoids: facts and hypotheses Cosima T. Baldari Siena, Italy W2.02.01 - Antagonistic actions of Rcor proteins refine LSD1 activity and restrain cellular differentiation A.H. Chowdhury, G. Upadhyay, D. Kim, Shireen Saleque New York, USA 16.45-18.15 SPACE 1 W2.04.05 - MicroRNA-146a promotes IVIg-mediated inhibition of NFB activation in LPS-treated human monocytes Lionel Loubaki, D. Chabot, I. Paré, R. Bazin Québec, Canada W2.02 - NUCLEAR RECEPTORS W2.02.05 - Th17-mediated B cell activation contributes to splenomegaly in PPAR hypomorphic mice Ya-Hui Liu, Y. Tsai, P. Tsai Tainan, Taiwan W2.02.06 - Expression levels of mRNA for GR, GR, 11HSD1 and GR/ ratio in peripheral blood mononuclear cells from patients with pulmonary tuberculosis, throughout the 6-month course of etiological treatment and 3 month following its completion L.D. D’Attilio, A. Díaz, B. Bongiovanni, N.S. Santucci, G. Dídoli, W. Gardeñez, A. Del Rey, H. Besedovsky, O.A. Bottasso, María L. Bay Rosario, Argentina W2.04.02 - The role of microRNA-142-5P in experimental colitis Anje A. te Velde, M.M.W. Slaman, F.H. van Dooren, C. Kunne, S.L. Meijer, K. Fluiter, E.W. Vogels, P.D. Moerland Amsterdam, Netherlands W2.04.06 - MicroRNA regulation of bacterial infection in the lung Hock L. Tay, G.E. Kaiko, P.M. Hansbro, P.S. Foster Newcastle, Australia W2.02.04 - Retinoic acid-rich microenvironment provides clonal survival cues for tumor and bacteria-specific CD8+ T cells Yanxia Guo, K. Pino-Lagos, R. Noelle Lebanon, USA W4.05.01 - Antigen transfer drives CD4 T cell activation in tuberculosis Smita Srivastava, J. Ernst New York, USA W4.05.02 - Accumulation of Gr-1dim myeloid-derived suppressor cells during experimental TB infection in mice Evgeny N. Tsiganov, A.M. Razinkova, I.V. Lyadova Moscow, Russian Federation W4.05.03 - Annexin1 plays a critical role in dendritic cells cross-presentation and protection against Mycobacterium tuberculosis Maziar Divangahi, F. Tzelepis, J. Daoud, J. Jaworska, T. Nishimura, M. Verway, K. Hassani-Ardakani, H.G. Remold, H. Vali, M. Tabrizian Montreal, Canada W4.05.04 - Analysis of the global CD8 T cell response during Mycobacterium tuberculosis infection Diana Di Liberto, M. La Manna, N. Caccamo, G. Pietra, C. Mingari, L.C. Sullivan, A.G. Brooks, F. Dieli Palermo, Italy 45 16.45-18.15 SPACE 1 Workshops August 24, 2013 W1.15 - INFLAMMASOME W4.05.05 - Cytokine polymorphisms, their influence and levels in Brazilian patients with pulmonary tuberculosis during anti-tuberculosis treatment Eliana Peresi, L.R.C. Oliveira, W.L. da Silva, E.A.P.N. da Costa, J.P. Araujo Junior, J.A. Ayres, M.R.P. Fortes, E.A. Graviss, A.C. Pereira, S.A. Calvi Botucatu, Brazil Chairs: Eicke Latz (DEU) Olaf Gross (CHE) IL.15.01 - Role of inflammasomes for chronic inflammatory diseases Eicke Latz Bonn, Germany W4.05.06 - Mycobacterium tuberculosis-specific lung innate and adaptive immunity in close contacts of TB index cases Jonathan G. Peter, A. Binder, M. Davids, R. Meldau, R. van Zyl-Smit, K. Dheda Cape Town, South Africa IL.15.02 - Inflammasome activators induce the secretion of IL-1 via two distinct pathways displaying differential requirement for a protease activityindependent function of caspase-1 Olaf Groß München, Germany W1.15.01 - Cytosolic cathepsin inhibitor Stefin B (Cystatin B) regulates NLRP3 inflammasome activation Katarina Maher, B. Jeric, B. Turk, N. Kopitar Jerala Ljubljana, Slovenia W5.10 - MULTIPLE SCLEROSIS IL5.10.01 - CNS tissue damage by T cells Roland Liblau Toulouse, France IL5.10.02 - Immunological knowledge integration in MS Marco Salvetti Rome, Italy 16.45-18.15 SPACE 3 Chairs: Roland Liblau (FRA) Marco Salvetti (ITA) 16.45-18.15 SPACE 2 W5.10.01 - Identification, isolation and characterization of brain-infiltrating, in situ clonally expanded T cell clones in multiple sclerosis Raquel Planas, N. Vilarrasa, B. Reinhart, S. HoffmeisterUllerich, I. Metz, W. Brück, B. Fehse, C. Pinilla, R. Martin, M. Sospedra Zürich, Switzerland W1.15.05 - TLRS-induced PAI-2 expression suppresses NLRP3-dependent caspase-1 activation and IL-1B processing L.C. Hsu, Shih-Yi Chuang, C. Yang, C. Lee, C. Chou Taipei, Taiwan W5.10.03 - Cell-intrinsic estrogen receptor activation in CD4+ T cells control Th1/Th17 differentiation in trans and protect from CNS autoimmunity Sophie Laffont, L. Garnier, N. Rouquié, J. Guéry Toulouse, France W1.15.06 - NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production Karina R. Bortoluci, V.M. Gonçalves, K.C. Matteucci, B.H. Miollo, C.L. Buzzo, D. Ferrante, J.M. Alvarez, M.M. Rodrigues Sao Paulo, Brazil W5.10.04 - A role for TNF signalling in cortical grey matter pathology in multiple sclerosis Roberta Magliozzi, P. Durrenberger, O. Howell, F. Roncaroli, E. Aricò, F. Aloisi, R. Reynolds London, United Kingdom 46 W3.11 - GAMMA-DELTA T CELLS Chairs: Dieter Kabelitz (DEU) Adrian Hayday (GBR) 16.45-18.15 SPACE 4 W5.10.06 - Confirmation of human endogenous retrovirus HERV-Fc1 role in multiple sclerosis risk Belen de la Hera, J. Varadé, I. Alloza, A. Alcina, R. Arroyo, R. Álvarez-Lafuente, K. Vandenbroeck, F. Matesanz, E. Urcelay Madrid, Spain W1.15.03 - The NLRP3 inflammasome links complement-mediated inflammation and IL-1 release Federica Laudisi, R. Spreafico, M. Evrard, B. Mandriani, S. Baalasubramanian, A. Mortellaro Singapore, Singapore W1.15.04 - Fas-mediated inflammatory response in Listeria monocytogenes infection Ryosuke Uchiyama, H. Tsutsui Nishinomiya, Japan W5.10.02 - T cells specific for both a myelin and a neuronal antigen are frequent in C57BL6 mice and contribute to CNS inflammation during EAE Liliana E. Lucca, A. Ramadan, S. Desbois-Beaumel, P. Rufas, J. Guery, T.L. Geiger, R.S. Liblau, L.T. Mars Toulouse, France W5.10.05 - Characterization of the impact of CD25 blockade on the NK and T cell populations of relapsing-remitting multiple sclerosis patients David J. Huss, D.S. Mehta, L. Amaravadi, J.S. Elkins, J.D. Fontenot Cambridge, USA W1.15.02 - The inflammasome adaptor ASC forms a prion-like danger signal that perpetuates inflammation Bernardo S. Franklin, D. De Nardo, G. Horvarth, S. Zimmer, S. Hornemann, A. Aguzzi, E. Latz Bonn, Germany IL3.11.01 - Regulatory interactions between granulocytes and gamma/delta T cells in response to aminobisphosphonates Dieter Kabelitz, V. Chandrasekaran, T.K. Lindhorst, S. Kalyan Kiel, Germany W3.11.01 - Heterogeneity and prognostic influence of tumor- infiltrating T lymphocytes in colon cancer patients Elena Lo Presti, S. Meraviglia, G. Cicero, V. Orlando, S. Buccheri, M.P. La Manna, D. Di Liberto, S. Cutrera, N.Caccamo, F. Dieli Palermo, Italy 16.45-18.15 SPACE 4 W3.11.02 - Key role of free heavy chain of HLA-I molecules in HCMV and tumor stress sensing by TCR Romain Marlin, S. Netzer, V. Pitard, S. Daburon, C. Harly, T. Bachelet, J. Moreau, J. Taupin, J. Déchanet-Merville Bordeaux, France W3.11.03 - Implication of T cells in the immune response against murine CMV Camille Khairallah, S. Netzer, M. Juzan, A. Villacreces, V. Praloran, J. Moreau, J. Dechanet-Merville, M. Capone Bordeaux, France 16.45-18.15 AMBER 1+2 Workshops August 24, 2013 W3.11.04 - HDAC7 plays a significant role in T cell development and function Matthew G. MacKenzie, C. Gawden-Bone, S. Matthews Dundee, United Kingdom Chairs: Emilio Jirillo (ITA) Giuseppe Matarese (ITA) IL6.02.01 - Polyphenols from red grape and modulation of the immune Response Emilio Jirillo, Y. Kumazawa, V. Pugliese, S. Fontana, G. Marzulli, T. Magrone Bari, Italy W3.11.06 - Major contribution of T cells to IL-17A production and ovarian cancer growth in vivo Margarida Rei, T. Lança, R. Thompson, F. Balkwill, H. Kulbe, B. Silva-Santos, D. Pennington Lisbon, Portugal IL6.02.02 - Intracellular metabolic pathways control immune tolerance Giuseppe Matarese Baronissi, Salerno, Italy W6.02.01 - Insulin impairs regulatory T cell function: implications for obesity Jonathan M. Han, S.J. Patterson, J.A. Ehses, M.K. Levings Vancouver, Canada W4.02 - LIVER VIRAL INFECTIONS Chairs: Mario Mondelli (ITA) Frank Chisari (USA) 16.45-18.15 AMBER 1+2 W4.02.02 - Reactive oxygen species delay control of lymphocytic choriomeningitis virus Haifeng C. Xu, D.R. McIlwain, A.A. Pandyra, M. Recher, D. Brenner, D. Häussinger, P.S. Ohashi, T.W. Mak, K.S. Lang, P.A. Lang Dusseldorf, Germany W4.02.03 - Cellular inhibitors of apoptosis (IAPs) play a critical role in the host response to hepatitis B virus and their repression promotes viral clearance Gregor Ebert, S. Preston, C. Allison, J. Toe, J. Cooney, H. Scott, M. Pellegrini Melbourne, Australia 16.45-18.15 AMBER 3+4 IL4.02.01 - Innate Sensing A Virus Designed Not To Be Seen Francis V. Chisari La Jolla, United States W4.02.01 - Dynamic changes in the liver upon persistent viral infection A. Bhattacharya, J. Colinge, K. Bennett, Andreas Bergthaler Vienna, Austria W4.02.06 - Breaking T cell tolerance to viral antigens in a model of chronic HBV infection Marianna Di Scala, I. Gil-Fariña, L. Vanrell, M. Scarpino, C. Olagüe, A. Vales, M. Galarraga, L. Guembe, J. Prieto, G. González-Aseguinolaza Pamplona, Spain W6.02 - METABOLISM AND IMMUNITY INTERFACES W3.11.05 - A network of High Mobility Group box transcription factors programs innate IL-17 production Nidhi Malhotra, K. Narayan, O. Cho, K. Sylvia, H. Melichar, M. Rashighi, V. Lefebvre, J.E. Harris, L.J. Berg, J. Kang Worcester, USA IL4.02.02 - NK cells and HCV: a complex and controversial relationship Mario U. Mondelli, S. Varchetta, B. Oliviero, S. Mantovani, D. Mele Pavia, Italy W4.02.05 - Tim-3/galecin-9 pathway modulates the cross talk between NK cells and CD8+ T cells in chronic hepatitis B D. Zhao, L. Gao, X. Liang, Chunhong Ma Jinan, China W6.02.02 - Investigating the anti-inflammatory effects of high density lipoprotein in macrophages Dominic De Nardo, L. Labzin, H. Kono, R. Seki, S. Schmidt, M. Kneilling, D. Lütjohann, S. Wright, J. Schultze, E. Latz Bonn, Germany W6.02.03 - Obesity-associated autoantibody production requires AIM to retain IgM immune complex on follicular dendritic cells Satoko Arai, S. Honda, A. Shibuya, Q. Li, T. Miyazaki Tokyo, Japan W6.02.04 - Novel factors regulating chemerin synthesis and function in fat tissue Mateusz Kwitniewski, M. Bana , N. Harasymowicz, J. Marczy ska, K. Kwiecie , B.A. Zabel, J. Cichy Krakow, Poland W6.02.05 - Amino acid sensing by mTORC1 is the vital prerequisite for alternative activation of macrophages Tetsuya Kimura, S. Nada, M. Okada, A. Kumanogoh Suita, Japan W6.02.06 - Gene profile of myeloid-derived suppressive cells from the bone marrow of lysosomal acid lipase knock-out mice Cong Yan, X. Ding, N. Dasgupta, L. Wu, H. Du Indianapolis, USA W4.02.04 - Imaging the innate immune response to viral infection: neutrophils, platelets, and NETs Craig N. Jenne, C.H.Y. Wong, F.J. Zemp, B. McDonald, M.M. Rahman, P.A. Forsyth, G. McFadden, P. Kubes Calgary, Canada 47 Workshops August 24, 2013 W3.14 - B CELLS IN AUTOIMMUNITY AND REGULATORY B CELLS W2.03.01 - Regulatory non-coding RNAs as modulators of human lymphocytes differentiation V. Ranzani, A. Arrigoni, R.J. Bonnal, Grazisa Rossetti, S. Curti, E. Sugliano, E. Provasi, V. Parente, S. Abrignani, M. Pagani Milan, Italy Chairs: Claudia Mauri (GBR) Fabienne Mackay (AUS) IL3.14.01 - TACI regulates T-independent marginal zone B cell responses through innate activation-induced cell death Fabienne Mackay, W. Figgett, A. Strasser, P. Hertzog, K. Fairfax, V. Fabien, D. Saulep-Easton, M. Le Page, L. O'Reilly, S. Gerondakis Melbourne, Australia 16.45-18.15 AMBER 5+6 W3.14.01 - Dual-reactive and autoreactive B cell selection and function in autoimmunity. Roberta Pelanda, E. Fournier, L. Teodorovic, C. Babolin, S. Rowland, R.M. Torres. Denver, USA 16.45-18.15 AMBER 7+8 IL3.14.02 - Regulatory B and iNKT cells interaction: novel mechanism of Suppression Claudia Mauri, A. Bosma, A. Abdel-Gadir, E. Jury London, United Kingdom W2.03.02 - Bromodomain inhibition enhances tolerogenic properties in dendritic cells Ronald Schilderink, L.E. Nijhuis, F.W. Hilbers, R.K. Prinjha, W.J. de Jonge Amsterdam, Netherlands W3.14.02 - The atypical IB protein IBNS is important for TLR-induced IL-10 production in B cells M. Miura, M. Noguchi, Maki Touma Niigata, Japan W2.03.06 - Unique epigenetic signatures are associated with the induction, silencing and re-expression of CD8 during T cell development and activation Kim L. Charlton, E.B. Day, B.E. Russ, S.H. Apte, S.J. Turner, A. Kelso Parkville, Australia W3.14.04 - Analysis of a wild mouse promoter variant reveals a novel role for FcRIIb in the control of the germinal center and autoimmunity Marion Espeli, M. Clatworthy, S. Boekers, K. Lawlor, A. Cutler, F. Koentgen, P. Lyons, K. Smith Cambridge, United Kingdom W1.10 - INNATE SENSORS Chairs: Roman Jerala (SLO) Cecilia Garlanda (ITA) W3.14.05 - Contribution of IL-10 competent regulatory B cells (CD19+CD24hiCD38hi) to cytotoxic T lymphocyte dysfunction after reactivation of HIV latent reservoirs. Basile Siewe, S. Rygielski, S. Deeks, J. Martin, A. Landay Chicago, USA 16.45-18.15 AMBER 7+8 16.45-18.15 BROWN 1 IL1.10.01 - The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules Cecilia Garlanda Rozzano, Italy IL1.10.02 - Association of TIR domains underlying immunosuppression in bacterial infection and activation of MyD88 mediated cell signaling associated with B-cell lymphoma O. Fekonja, M. Avbelj, Roman Jerala Ljubljana, Slovenia Chairs: Riitta Lahesmaa (FIN) Massimiliano Pagani (ITA) W1.10.01 - Viral inhibition of DNA-PK-dependent DNA sensing Brian J. Ferguson, N.E. Peters, D.S. Mansur, M. Mazzon, H. Ren, A.S. Fahy, E. Krysztofinska, R. Arribas-Bosacoma, L.H. Pearl, G.L. Smith Cambridge, United Kingdom IL2.03.01 - Epigenomic and transcriptional regulation of human Th cell differentiation Riitta Lahesmaa Turku, Finland W1.10.02 - Hepatitis C virus degrades Riplet ubiquitin ligase to escape host innate immune response Hiroyuki Oshiumi, M. Matsumoto, T. Seya Sapporo, Japan W2.03 - EPIGENETIC CONTROL OF IMMUNE RESPONSES 48 W2.03.04 - Loss of an Ig gene enhancer in mature B cells results in rapid gene silencing and partial reversible de-differentiation X. Zhou, Y. Xiang, William T. Garrard Dallas, USA W2.03.05 - Regulation of CD4 T helper cell differentiation and plasticity by the histone methyltransferase Ezh2 Damon J. Tumes, A. Onodera, C. Iwamura, H. Hosokawa, H. Koseki, K. Tokoyoda, Y. Suzuki, T. Nakayama Chiba, Japan W3.14.03 - Aicda expression in immature B cells, but not in mature B cells is critical for IgG autoantibody production in a model of systemic lupus erythematosus Benjamin Umiker, A. Larbi, M. Reth, T. Honjo, T. ImanishiKari Boston, USA W3.14.06 - Human innate-like B cells with regulatory properties in response to viruses X. Zhang, Dania Zhivaki, S. Lemoine, A. Lim, C. Leclerc, R. Lo-Man Paris, France W2.03.03 - The Polycomb group protein Ezh2 regulates the germinal center B cell response Stefano Casola, M. Caganova, C. Carrisi, F. Zanardi, F. Mainoldi, L. George, M. Ponzoni, K.M. Toellner, I. Su Milan, Italy Workshops August 24, 2013 W1.10.03 - Lysosomal DNase2a is required for the autophagic clearance of self damaged nuclear DNA Yuk Yuen Lan, D. Londono, N. Hacohen Charlestown, USA W1.10.04 - Commensal microbiota monitoring by RLRs regulates contact hypersensitivity response Emilie Plantamura, L. Moudombi, S. Djebali, C. Macari, S. Lippens, A. Dzutsev, G. Trinchieri, J. Marvel, M.C. Michallet Lyon, France W1.10.05 - Essential role for Bruton’s tyrosine kinase outside the B cell compartment in bacterial infection Alex F. De Vos, J. Pater, R. De Beer, S. Terpstra, C. Van ‘t Veer, R. Hendriks, T. Van Der Poll Amsterdam, Netherlands W1.10.06 - Genetic variants in donor PTX3 impair antifungal immunity and predispose to invasive aspergillosis after stem cell transplantation C. Cunha, F. Aversa, A. Mantovani, L. Romani, Agostinho Carvalho 16.45-18.15 BROWN 1 Perugia, Italy 49 Chair: Peter Parham (USA) Peter C. Doherty (AUS) Fifty years of cytotoxic T cells PS.06 - PERSPECTIVES IN IMMUNOLOGY Chair: John Hamilton (USA) Siamon Gordon (GBR) Macrophage receptors and immune activation PL.05 - PLENARY LECTURE Chair: Alexander Rudensky (USA) Maria Grazia Roncarolo (ITA) Immune tolerance mediated by T regulatory type 1 cells LL.17 - LUNCHTIME LECTURE Chair: David Wallach (ISR) Peter Krammer (DEU) Decisions of life and death LL.19 - LUNCHTIME LECTURE Chair: Paola Ricciardi Castagnoli (SNG) Xuetao Cao (CHN) Cross-regulation of innate inflammatory respons 12.30 - 13.15 BROWN 3 LL.15 - LUNCHTIME LECTURE 12.30 - 13.15 SPACE 1+2 Chair: Maria Grazia Roncarolo (ITA) Shimon Sakaguchi (JPN) Control of immune responses by regulatory T cells 12.30 - 13.15 SPACE 4 12.30 - 13.15 GOLD ROOM 12.30 - 13.15 BROWN 1+2 12.30 - 13.15 SPACE 3 LL.16 - LUNCHTIME LECTURE Chair: Antonio Lanzavecchia (CHE) Andreas Radbruch (DEU) The emerging diversity of immunological memory LL.18 - LUNCHTIME LECTURE Chair: Marco Cassatella (ITA) Clifford A. Lowell (USA) Tyrosine kinases and phosphatases in inflammation and autoimmunity LL.20 - LUNCHTIME LECTURE Chair: Douglas Golenbock (USA) Ricardo Gazzinelli (BRA) Toxoplasma recognition by TLR11/TLR12 heterodimers: a tale of mice (cats) and men LL.21 - LUNCHTIME LECTURE Chair: Gioacchino Natoli (ITA) Joost Oppenheim (USA) The defensin and HMGN1 alarmins have potent adjuvant effects 18.30 - 19.15 GOLD ROOM 12.30 - 13.15 AMBER 1+2 50 8.50 - 9.20 SPACE 1+2 PS.05 - PERSPECTIVES IN IMMUNOLOGY 9.30 - 10.15 GOLD ROOM 8.50 - 9.20 GOLD ROOM Main Lectures August 25, 2013 PL.06 - PLENARY LECTURE Chair: Marc Feldamann (GBR) Antonio Lanzavecchia (CHE) Dissecting the antibody response to pathogens and self antigens S13 - AUTOIMMUNE MECHANISMS S14 - GENE AND CELL THERAPY Chair: Chairs: Adrian Thrasher (GBR) Carlo Riccardi (ITA) Paola Romagnani (ITA) S14.01 Stem cell and kidney regeneration Antonio Uccelli (ITA) S14.02 Mesenchymal stem cells modulate the immune response in vivo Matthias Edinger (DEU) S14.03 Regulatory T cells in allogeneic stem cell transplantation Masaru Taniguchi (JPN) S14.04 NKT cells as an ideal target for anti-tumor immunotherapy Alessandro Aiuti (ITA) S14.05 Gene therapy for primary immunodeficiencies Alberto Martini (ITA) Eric Gershwin (USA) S13.01 Primary biliary cirrhosis: the environment and autoimmunity Ethan Shevach (USA) S13.02 Control of dendritic cell function by T regulatory cells Virginia Pascual (USA) S13.03 Novel B cell-helper pathways in human SLE Reinhold E. Schmidt (DEU) S13.04 Innate mechanisms in antibody mediated autoimmune diseases David A. Hafler (USA) S13.05 Regulatory T cells in autoimmune disease 10.20 - 12.25 SPACE 1+2 10.20 - 12.25 GOLD ROOM Parallel Symposia August 25, 2013 S16 - ANTIGEN PROCESSING AND PRESENTATION Chairs: Martin Lipp (DEU) Mario Mellado (ESP) Philip M. Murphy (USA) S15.01 Chemokines: tails from the clinic Andrew D. Luster (USA) S15.02 Chemokine guidance in the lymph node imprints adaptive immune responses Silvano Sozzani (ITA) S15.03 Role of the atypical chemokine receptor CCRL2 in immune responses Klaus Ley (USA) S15.04 Toward an antigen-specific therapy for atherosclerosis Kouji Matsushima (JPN) S15.05 Dynamisms and regulation of tumorassociated myeloid cells 10.20 - 12.25 BROWN 3 10.20 - 12.25 BROWN 1+2 S15 - CELL TRAFFICKING S18 - BACTERIAL INFECTIONS 10.20 - 12.25 SPACE 4 10.20 - 12.25 SPACE 3 S17 - COMPLEMENT AND SOLUBLE MEDIATORS Chairs: Marina Botto (GBR) Mariagrazia Uguccioni (CHE) John Lambris (USA) S17.01 The Renaissance of Complement Teizo Fujita (JPN) S17.02 Functional aspect of the lectin complement pathway Seppo Meri (FIN) S17.03 Trick or treat - how pathogens handle the complement system Francesco Tedesco (ITA) S17.04 The complement system: friend or foe? Paul Herzog (AUS) S17.05 A unique type I interferon regulates mucosal innate immune responses in the female reproductive tract Chairs: Emil Unanue (USA) Kenneth Rock (USA) Jacques Neefjes (NLD) S16.01 Genome-wide analyses defines new factors controlling MHC class I and MHC class II antigen presentation Peter Cresswell (USA) S16.02 Molecular aspects of MHC class I-restricted antigen processing Jose Villadangos (AUS) S16.03 Regulation of antigen presentation in the dendritic cell network Sebastian Amigorena (FRA) S16.04 Antigen crosspresentation in dendritic cells Muriel Moser (BEL) S16.05 Regulatory T cells control Th1 priming by inhibiting CD70 expression: a role for intercellular transfer of CD27? Chairs: Francesco Dieli (ITA) Giuseppe Teti (ITA) Russell E. Vance (USA) S18.01 Activation of inflammasomes by bacterial pathogens Jurgen Ruland (DEU) S18.02 CARD9 signaling complexes in innate immunity Robert L. Modlin (USA) S18.03 Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses Francesco Dieli (ITA) S18.04 HLA-E-restricted recognition of Mycobacterium tuberculosis by human CD8 T lymphocytes Willem Hanekom (ZAF) S18.05 Human correlates of risk of TB disease 51 Sponsored Sessions August 25, 2013 13.30 - 15.00 SPACE 3 12.30 - 15.10 AMBER 5+6 STANDARDIZATION IN IMMUNOLOGY. IMPORTANCE FOR HEALTH AND DISEASE IUIS Lunch Symposium Chair: Rudolf Valenta (AUT) Ruby Pawankar (JPN) Importance of standardization in immunology and allergy: a WAO perspective Stefan Vieths (DEU) Major allergen ELISA’s and recombinant allergens in allergens standardization Luis Andrade (BRA) The impact of different methodological platform and standards in the diagnostic performance of autoantibodies Alberto Falorni (ITA) Standardization of adrenal autoantibody determination in Europe Pablo Engel (ESP) CD molecules. Standardization of monoclonal antibody validation Michael Kirschfink (DEU) Modern complement analysi Vladka urin Šerbec (SLO) Goals and challenges and its impact on the immunological diagnostics Clemens Scheinecker (AUT) The Subcommittee for the Standardization and Quality Assesment in Immunotherapy: the need for expert opinions INNOVATIVE FLOW CYTOMETRY TO DECIPHER IMMUNE CELL FUNCTION with the contribution of BD Bioscience Chair: Robert Balderas (USA) Jurg Rohrer (USA) Innovative tools to incorporate low density antigens in multicolor panels Claudia Mauri (GBR) Regulatory B cells maintain regulatory T cells whilst inhibiting Th17 and Th1 differentiation 15.10 - 16.40 SPACE 1 13.30 - 15.00 SPACE 4 INFECTIOUS AGENTS AND AUTOIMMUNITY - PART II with the contribution of Italian Ministry of Health and Italian Multiple Sclerosis Foundation Chairs: Francesca Aloisi (ITA) - Christian Münz (CHE) Patrick J. Venables (GBR) Porphyromonas gingivalis and autoimmunity in rheumatoid arthritis Jan Lünemann(CHE) Virus-host interactions in multiple sclerosis Francesca Aloisi (ITA) Epstein-Barr virus and lymphoid neogenesis in autoimmunity Christian Münz (CHE) Translational aspects and discussion PRIMARY BILIARY CIRRHOSIS: GENETICS, PATHOGENESIS AND THERAPY OF A PROTOTYPIC AUTOIMMUNE DISEASE with the contribution of Intercept Pharmaceuticals Chair: Luciano Adorini (ITA) Pietro Invernizzi (ITA) Recent progress in genetics and epigenetics of PBC M. Eric Gershwin (USA) Environmental factors and the pathogenesis of PBC David Shapiro (USA) New therapies for PBC 19.15 - 20.15 GOLD ROOM 15.10 - 17.10 SPACE 3 NEW INSIGHTS IN CHEMOKINE ALLOSTERIC INHIBITORS 52 With the contribution of Dompé S.p.A. Chair: Mauro Teixeira (BRA) David Scholten (NLD) Pharmacological modulation of chemokine receptors function Mette Rosenkilde (DEN) Major players in 7TM receptor activation; structural features of chemokine receptors Massimo Locati (ITA) Dissecting trafficking and signaling of typical and atypical chemokine receptors Marcello Allegretti (ITA) A structurally conserved allosteric motif beyond the chemokine receptor family ELSE KRÖNER-FRESENIUS AWARD LECTURE Welcome note: Susanne Schultz-Hector, executive board Else Kröner-Fresenius-Stiftung Introduction: S.H.E. Kaufmann, IUIS president Award lecture by the winner of the Else Kröner-Fresenius-Award Workshops August 25, 2013 W3.13 - REGULATORY T CELLS: BASIC ASPECTS Stefano Angiari, B. Rossi, L. Piccio, B.H. Zinselmeyer, S.L. Budui, E. Zenaro, V. Della Bianca, A.H. Cross, M.J. Miller, G. Constantin Verona, Italy Chairs: Hans-Jorg Schild (DEU) Barbara Fazekas de St Groth (AUT) W3.13.10 - Visualizing tolerance induction: behavior and function of regulatory T cells during the establishment of materno/fetal tolerance Maria-Grazia G. Ruocco, T. Chen, G. Darrasse-Jeze, D. Klatzmann Paris, France IL3.13.01 - Regulatory T cells fine-tune DC costimulation in vivo to set the threshold for T cell activation Barbara Fazekas de St Groth, H. Bolton, C. Zhu Sydney, Australia W3.13.01 - Low/negative expression of CD6 in natural T-regulatory cells Carlos A. Garcia Santana, J.W. Tung, S. Gulnik Miami, United States W3.13.02 - Regulatory T cells increase the avidity of CD8+ T cell responses to non-self antigens and promote memory Luigia Pace, A. Tempez, C. Arnold-Schrauf, F. Lemaitre, P. Bousso, L. Fetler, T. Sparwasser, S. Amigorena Paris, France 15.10-18.15 GOLD ROOM IL3.13.02 - Impaired peripheral tolerance as a consequence of disturbed regulatory T cells - dendritic cell interactions Hansjörg Schild, S. Muth, H. Probst Mainz, Germany W3.13.14 - TCR-independent CD4+CD25+ regulatory T cell activation during immune responses Hidefumi Kojima, Y. Kashiwakura, M. Hashiguchi, T. Kobata Mibu, Japan W3.13.05 - TGF- signalling is required for CD4+ T cell homeostasis but dispensable for regulatory T cell function Anna Sledzinska, S. Hemmers, F. Mair, O. Gorka, J. Ruland, L. Fairbairn, W. Müller, A. Waisman, B. Becher, T. Buch Zurich, Switzerland W3.13.08 - Selective inhibition of pro-inflammatory T cell responses by TIGIT+ Tregs Nicole Joller, S. Xiao, B. Patel, C. Zhu, J. Xia, F.J. Quintana, V.K. Kuchroo Boston, USA W3.13.09 - Regulatory T cells suppress the late phase of the immune response in lymph nodes through Pselectin glycoprotein ligand-1 W4.03 - HIV PATHOGENESIS AND IMMUNITY Chairs: Guido Poli (ITA) Andrea Cossarizza (ITA) IL4.03.01 - The Fight Between HIV Infection and Macrophage Polarization Guido Poli Milano, Italy 15.10-18.15 BROWN 3 15.10-18.15 GOLD ROOM W3.13.04 - Continuous interactions with self are required for maintaining regulatory CD4 T cell numbers and suppressive capacities in the periphery Arnaud Delpoux, P. Yakonowsky, A. Pommier, C. Charvet, M. Valente, A. Durand, B. Martin, C. Auffray, B. Lucas Paris, France W3.13.07 - Human regulatory T cells rapidly suppress T cell receptor-induced calcium, NF-B, and NFAT signalling in conventional T cells Angelika Schmidt, N. Oberle, R. Joshi, S. Frischbutter, R. Baumgrass, H. Lin, G.W. Mayr, E. Suri-Payer, J. Tegner, P.H. Krammer Solna, Sweden W3.13.12 - Der P 1 induced CD4+FOXP3+GATA3+ T cells have suppressive properties while contributing to the polarization of the Th2 response Lieke L. Reubsaet, J. Meerding, R. Giezeman, I.M. de Kleer, H.G.M. Arets, B.J. Prakken, J. Beekman, F. van Wijk Utrecht, Netherlands W3.13.13 - Highly pure human antigen-specific Tregs with superior function in preventing allograft rejection Fatih Noyan, M. Hardtke-Wolenski, Y. Lee, R. Taubert, G. Warnecke, A. Knoefel, E. Schulde, S. Olek, M.P. Manns, E. Jaeckel Hannover, Germany W3.13.03 - Costimulatory requirements for Treg homeostasis and function C. Wang, R. Kenefeck, L. Wardzinski, Lucy S. Walker London, United Kingdom W3.13.06 - Essential role for Bcl11b in the FoxP3 transcriptional complex and T regulatory cells suppressive function Masahide Hamaguchi, K. Sakai, N. Ohkura, H. Morikawa, Y. Shimazu, J.B. Wing, S. Sakaguchi Suita, Japan W3.13.11 - Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells Achille Broggi, C. Vitali, F. Mingozzi, S. Barresi, G. Raimondi, I. Zanoni, F. Granucci Milan, Italy W4.03.01 - Endoplasmic reticulum aminopeptidase 2 (ERAP2) haplotypes play a role in antigen presentation and resistance to HIV-1 infection Irma Saulle, M. Biasin, F. La Rosa, M. De Luca, D. Trabattoni, M. Sironi, R. Cagliani, F. Mazzotta, S. Lo Caputo, M. Clerici Milan, Italy W4.03.02 - Molecular characterization of high avidity CD4+ T cells in HIV controllers Daniela Benati, M. Galperin, O. Lambotte, A. Lim, B. Lemercier, S. Hendou, F. Boufassa, J. Delfraissy, F. Arenzana-Seisdedos, L. Chakrabarti Paris, France W4.03.03 - Characterization of HIV-1 specific T cell response in an Italian cohort of HIV-1 natural controllers Davide De Battista, D. Mennonna, S. Heltai, E. De Martino, A. Riva, M. Tinelli, S. Nozza, S. Ghezzi, G. Poli, M. Malnati Milan, Italy 53 W4.03.04 - NK cells in HIV controller patients express an activated effector phenotype and do display unique NKp46,NKp30,NKp44 modulation on IL-2 stimulation Francesco Marras, E. Nicco, F. Bozzano, A. Di Biagio, C. Dentone, G. Orofino, F. Bisio, A. Riva, L. Moretta, A. De Maria. Genoa, Italy 15.10-18.15 BROWN 3 Workshops August 25, 2013 W2.06 - LEUKOCYTE TRAFFICKING W4.03.05 - Inhibition of human immunodeficiency virus type-1 replication in CD4+ NKT cells by T lymphocytes Kyoko Omi, M. Shimizu, E. Watanabe, A. Owaki, C. Takaku, E. Shinya, H. Takahashi Tokyo, Japan Chairs: Ruggero Pardi (ITA) Giorgio Berton (ITA) W2.06.01 - Clathrin light chain subunits control actin organization during infection and lymphocyte migration Frances M. Brodsky, M. Bonazzi, P. Cossart, P. Parham, S. Majeed San Francisco, USA W4.03.06 - Immune exposure to a specific sequence of antibody escape variants could program long-term potential for neutralization breadth in subtype A HIV-1 infection Megan K. Murphy, L. Yue, R. Pan, A. Sethi, E. Karita, S.A. Allen, J.E. Robinson, S. Gnanakaran, X. Kong, C.A. Derdeyn Atlanta, USA W4.03.08 - Telomere length and CD38 expression on monocytes and CD8 T cells of HIV infected people Maciej Tarkowski, D. Misciagna, F. Strambio de Castillia, C. Gervasoni, C. Resnati, L. Ferraris, R. Piolini, M. Galli, A. Riva Milan, Italy W2.06.02 - DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses Yousuke Harada, Y. Tanaka, M. Terasawa, J.V. Stein, T. Kinashi, Y. Fukui Fukuoka, Japan 15.10-16.40 SPACE 2 15.10-18.15 BROWN 3 W4.03.07 - Decrease of CD73 expressing CD8 T cells in the course of HIV infection correlates with immune activation and T cell exhaustion Ilona Tóth, A.Q. Le, P. Hartjen, A. Thomssen, C. Beisel, A.W. Lohse, J. Hauber, J. van Lunzen, J.C.R. Schulze zur Wiesch Hamburg, Germany W4.03.09 - HIV-1 infection impairs CD34+ hematopoietic progenitor cells differentiation toward dendritic cells Veronica Bordoni, D. Viola, A. Sacchi, G. Castelli, M. Bibas, A. Ammassari, C. Agrati, A. Amendola, I. Abbate, F. Martini Rome, Italy 54 W2.06.04 - The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate A. Mendoza, B. Breart, W.D. Ramos-Perez, L.A. Pitt, M. Gobert, M. Sunkara, J.J. Lafaille, A.J. Morris, Susan R. Schwab New York, USA W2.06.06 - A mechanism of the skin-infiltration of basophils that is essential for the acquired protective immunity to tick infestation Soichiro Yoshikawa, T. Ohta, K. Ishiwata, K. Horiguchi, L. Li, K. Miyake, Y. Kawano, H. Kanuka, N. Watanabe, H. Karasuyama Tokyo, Japan 15.10-16.40 SPACE 4 W4.03.11 - HIV-infected T cells are migratory vehicles for viral dissemination Thomas T. Murooka, M. Deruaz, F. Marangoni, V. Vrbanac, E. Seung, U. von Andrian, A. Tager, A. Luster, T.R. Mempel Boston, USA W4.03.13 - Trogocytosis between germinal center B cells and TFH cells during acute SIV infection of macaques Ankita Chowdhury, P.M. Del Rio Estrada, M. Reuter, N. Patel, T. Hayes, S.E. Bosinger, J.D. Estes, M. Paiardini, M. Betts, G. Silvestri Atlanta, USA W2.06.03 - All-trans retinoic acid and rapamycin synergize with transforming growth factor- to induce regulatory T cells but confer distinct in vivo migratory capacities Giorgio Raimondi, S. Jhunjhunwala, L.C. Chen, E.E. Nichols, Y.T. Nicholson, A.W. Thomson, S.R. Little Baltimore, USA W2.06.05 - D6 is a -arrestin-biased signalling chemokine scavenger receptor Cinzia Cancellieri, E.M. Borroni, A. Vacchini, Y. Benureau, F. Bachelerie, F. Arenzana-Seisdedos, K. Mizuno, A. Mantovani, R. Bonecchi, M. Locati Milan, Italy W4.03.10 - Over-production of BAFF by dendritic cells and inflammatory monocytes during primary HIV-1 infection Gwenoline Borhis, N. Chaoul, C. Gilbert, C. Gras, C. Goujard, L. Meyer, S. Paul, H. Saoudin, J. Herbeuval, Y. Richard Paris, France W4.03.12 - TLR3 activation on dendritic cells causes complete suppression of HIV-1 infected dendritic cells by inducing up-regulation of microRNA-155 and APOBEC-3G Fiorella P. Rossi, G. Swaminathan, J. Martin-Garcia Philadelphia, USA W4.03.14 - Characterization of XCR1+ dendritic cells in healthy and SIV-infected rhesus macaques Charles-Antoine Dutertre, J. Jourdain, M. Rancez, S. Amraoui, Y. Richard, M. Dalod, V. Feuillet, R. Cheynier, A. Hosmalin Paris, France W1.14 - CYTOKINES AND OTHER REGULATORY MEDIATORS OF INFLAMMATION Chairs: Francesca Fallarino (ITA) Fernando Q. Cunha (BRA) IL1.14.01 - Endotoxin tolerance as a novel defence strategy in infectious diseases Francesca Fallarino, M. Gargaro, A. Bessede, D. Matino, G. Servillo, L. Tissi, L. Romani, U. Grohmann, P. Puccetti Perugia, Italy Workshops August 25, 2013 15.10-16.40 SPACE 4 W1.14.02 - The BAFF/Th17 axis in Helicobacter pylori infection Fabio Munari, M. Fassan, M. Cassatella, M. de Bernard Padua, Italy W1.14.03 - Molecular basis of signalling through the IL-36 receptor Eric J. Sundberg Baltimore, USA 15.10-16.40 AMBER 1+2 W1.14.01 - Expression and regulation of IL-35 in human tolerogenic dendritic cells and its role in regulating T cells responses Karen O. Dixon, S. van der Kooij, N. Schlagwein, D. Vignali, C. van Kooten Leiden, Netherlands W6.07.04 - Gene therapy mediated by lentiviral vector transduced CD34+ cells for the treatment of Wiskott-Aldrich syndrome Samantha Scaramuzza, F. Ferrua, M.C. Castiello, S. Giannelli, L. Biasco, F. Ciceri, M.G. Roncarolo, A. Villa, L. Naldini, A. Aiuti Milan, Italy W6.07.05 - Multifunctional CD26hi Th17 cells eradicate large human tumors Michelle H. Nelson, L. Huff, S. Kundimi, M. Goodyear, S.R. Bailey, C.M. Paulos Charleston, USA W6.07.06 - Identification of an alternative specificity for engineered T cells expressing an enhanced affinity MAGE-A3 TCR Bent K. Jakobsen, B.J. Cameron, A.B. Gerry, J. Dukes, J.V. Harper, E.A. Stadtmauer, A.P. Rapoport, C.H. June, N.J. Hassan, M. Kalos Abingdon, United Kingdom W1.14.04 - Intracellular signalling involved in IL-22 release by dendritic cells Maria Foti, S. Fumagalli, S. Citterio, C. Ripamonti Milan, Italy W1.14.05 - Environmental conditions perceived by the brain alter CD4+ T cell responses through an adiponectin-dependent mechanism Magdalena M. Canali, J.A. Soria, E. Murris, J. Chabry, A. Guyon, A. Paitel, N. Zsürger, E. Mougneau, N. Glaichenhaus Sophia Antipolis, France W3.05 - ANTIGEN PROCESSING AND PRESENTATION Chairs: Kayo Inaba (JPN) Peter van Endert (FRA) IL3.05.01 - Compartment cross-talk controlling phagosome maturation and exogenous antigen presentation in dendritic cells Peter van Endert, M. Weimershaus, J. Babdor, D. Descamps, A. Lennon-Dumenil, M. Zwick, T. Brocker, L. Saveanu Paris, France W1.14.06 - The non-specific and sex-differential immunological effects of the Bacillus Calmette-Guerin (BCG) vaccine in infants Kristoffer J. Jensen, N. Larsen, S. Biering-Sørensen, H.B. Eriksen, M.J. Jørgensen, D. Hougaard, K. Flanagan, P. Aaby, C.S. Benn Copenhagen, Denmark W3.05.01 - The true story of how MHC peptides are produced Arie Admon, L. Gutter-Kapon, E. Milner, D. Bourdetsky, E. Barnea, I. Beer Haifa, Israel W6.07 - CELL-BASED THERAPY 15.10-16.40 AMBER 1+2 IL6.07.01 - Cell therapy to induce tolerance: which cell type should we use? Giovanna Lombardi, R. Lechler London, United Kingdom W6.07.01 - Human CD8+ regulatory T cells inhibit GVHD and preserve general immunity in humanized mice Jian Zheng, Y. Liu, Y. Liu, M. Liu, Z. Xiang, K. Lam, D.B. Lewis, Y. Lau, W. Tu Hong Kong, Hong Kong W6.07.02 - Therapeutic efficacy of human mesenchymal stromal cells in a humanised mouse model of acute GVHD Karen English, L. Tobin, M. Healy, B.P. Mahon Co Kildare, Ireland W6.07.03 - Induction of donor-specific tolerance in organ transplantation using in vitro-generated immunosuppressive myeloid blood cells Christian Kleist, F. Sandra-Petrescu, L. Jiga, L. Dittmar, E. Mohr, J. Greil, G. Opelz, P. Terness Heidelberg, Germany 15.10-16.40 AMBER 3+4 Chairs: Giovanna Lombardi (GBR) Hideki Ueno (USA) W3.05.02 - ER-resident editors optimize distinct features of the peptide cargo loaded onto MHC-I molecules T. Kanaseki, K.C. Lind, H. Escobar, N. Nagarajan, E. ReyesVargas, B. Rudd, L. Van Kaer, N. Sato, J. Delgado, Nilabh Shastri Berkeley, USA W3.05.03 - A CD74-dependent MHC-I endolysosomal cross-presentation pathway Wilfred A. Jefferies, G. Basha, K.D. Omilusik, A. ChavezSteenbock, A.T. Reinicke, N. Lack, K. Choi Vancouver, Canada W3.05.04 - IRAP endosomes are an intracellular crossroad of innate and adaptive immunity Loredana Saveanu, M. Weimershaus, J. Babdor, M. Tohme, P. Vargas, A. Lennon-Dumenil, D. Descamps, B. Manoury, P. van Endert Paris, France W3.05.05 - CD4 T cell receptor transgenic mice recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes James F. Mohan, B. Calderon, E.R. Unanue Saint Louis, USA 55 15.10-16.40 AMBER 3+4 Workshops August 25, 2013 W3.05.06 - Structural basis of human beta-cell killing by CD8+ T cells in type 1 diabetes David K. Cole Cardiff, United Kingdom W5.03.01 - Effect of multiple genetic risk factors associated with rheumatoid arthritis on immune cell phenotypes Lucia Chovanova, M. Vlcek, K. Krskova, F. Spoutil, J. Rovensky, R. Brownlie, R. Zamoyska, R. Imrich Bratislava, Slovakia W5.03.02 - Variants in the IRF5-TNPO3 locus are associated with the development of lupus and its clinical presentation and shared with other autoimmune disorders Leah C. Kottyan, E.E. Zoller, S. Hawtrey, K.M. Kaufman, J.B. Harley Cincinnati, USA W3.08 - Th1 AND Th2 CELLS Chairs: Enrico Maggi (ITA) W3.08.01 - Crucial role of IL-18R1 signalling in Th1 cell differentiation in mice infected with Trypanosoma cruzi A. Oliveira, A.P. Granato, J.F. Gomes-Neto, C.H.D. Barbosa, F.B. Canto, R. Fucs, A. Nobrega, Maria Bellio Rio de Janeiro, Brazil 15.10-16.40 AMBER 5+6 W3.08.02 - Pro- and anti-inflammatory cytokine signals control the balance between Th1 and Tfh differentiation during the first few days of viral infection Heather D. Marshall, I.A. Parish, M. Staron, B.J. Laidlaw, J. Ray, J. Craft, S.M. Kaech New Haven, USA 15.10-16.40 AMBER 7+8 Barbara Bohle (AUT) W3.08.03 - CD4+ T cells are both trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection D.G. Kugler, P.R. Mittlesstadt, J.D. Ashwell, A. Sher, Dragana Jankovic Bethesda, USA W5.03.06 - Vav1 cooperate with Themis to modulate regulatory T cell suppressive functions Christophe Pedros, M. Chabod, A. Dejean, I. Bernard, O. Andreoletti, G. Fournié, A. Saoudi Toulouse, France W3.08.05 - RNA-binding protein HuR coordinately regulates GATA-3 and CD4+ Th2 cytokine gene expression in dose-dependent manner Ulus Atasoy, M. Gubin, R. Calaluce, J. Martindale, M. Gorospe, C. Stellato, V. Casolaro Columbia, USA 15.10-16.40 AMBER 7+8 Chairs: Rosa Sorrentino (ITA) Manfred Herold (AUT) IL5.03.01 - HLA-B27 micropolymorphisms correlate with differences in function and susceptibility to Ankylosing Spondylitis M.T. Fiorillo, V. Tedeschi, C. Vitulano, F. Paladini, G. Camilli, C. Rossetti, S. Tuncer, Rosa Sorrentino Roma, Italy W1.08 - DENDRITIC CELL SUBSETS Chairs: Michel Gilliet (CHE) Franca Ronchese (NZL) IL1.08.01 - Increased numbers of monocyte-derived DC in the lymph node during successful tumor treatment with immune activating agents S. Kuhn, E. Hyde, F. Rich, J. Harper, J. Kirman, Franca Ronchese Wellington, New Zealand 15.10-16.40 BROWN 1 W5.03 - GENETICS OF AUTOIMMUNITY W5.03.04 - Genetic variants in PXK are associated with the development of lupus and critically regulate BCR internalization Samuel E. Vaughn, I.T.W. Harley, C. Foley, L.C. Kottyan, K.M. Kaufman, J.A. Kelly, J.B. Harley Cincinnati, USA W5.03.05 - Enhanced apoptosis by disruption of the STAT3-IB- signalling pathway in epithelial cells induces Sjögren’s syndrome-like autoimmune disease A. Okuma, K. Hoshino, T. Kaisho, Tatsushi Muta Sendai, Japan W3.08.04 - Blimp-1 triggers the formation of immunoregulatory IL-10 producing Th1 cells during chronic viral infection Ian A. Parish, H.D. Marshall, P.A. Lang, A. Brustle, J.H. Chen, W. Cui, P.S. Ohashi, C.T. Weaver, S.M. Kaech Canberra, Australia W3.08.06 - Modifications of the bone marrow microenvironment in the transition from monoclonal gammopathy of undetermined significance to multiple myeloma in Vk*MYC mice Arianna Calcinotto, E. Cattaneo, M. Grioni, S. Bertilaccio, M. Chesi, L. Bergsagel, G. Casorati, P. Dellabona, M. Bellone Milan, Italy W5.03.03 - The lupus-associated variant of the ITGAM allele (rs1143679) impairs phagocytosis, but not migration nor TLR7/8 induced cytokine release Liliane Fossati-Jimack, G.S. Ling, A. Cortini, M. Szajna, T.H. Malik, J.U. McDonald, M.C. Pickering, H.T. Cook, P.R. Taylor, M. Botto London, United Kingdom W1.08.01 - Characterization of human afferent lymph dendritic cells from seroma fluids Barbara Morandi, I. Bonaccorsi, R. Conte, G. Costa, R. Iemmo, S. Ferrone, C. Cantoni, M. Mingari, L. Moretta, G. Ferlazzo Genoa, Italy W1.08.02 - Plasmacytoid, conventional and monocyte-derived dendritic cells undergo a profound and convergent genetic reprogramming during their maturation T. Vu Manh, Y. Alexandre, T. Baranek, K. Crozat, Marc Dalod Marseille, France W1.08.03 - The dendritic cells of the bone marrow Ben R. Fancke, J. Pooley, M. O’Keeffe Melbourne, Australia 56 Workshops August 25, 2013 W1.16 - COMPLEMENT SYSTEM Chairs: Anna Erdei (HUN) George N. Hajishengallis (USA) IL1.16.01 - Microbial manipulation of select host signaling pathways to disengage immune bacterial clearance from inflammation George Hajishengallis, T. Maekawa, J.L. Krauss, K.B. Hosur, J.D. Lambris Philadelphia, United States W1.08.05 - In vivo roles of XC chemokine receptor 1expressing dendritic cells Tomokazu OHTA, H. Hemmi, C. Yamazaki, M. Sugiyama, I. Sasaki, K. Hoshino, T. Kaisho Suita, Japan + W1.16.01 - C3 opsonisation enhances apoptotic cellassociated antigen presentation by DCs by controlling the endocytic handling Lucie Baudino, A. Sardini, M. Ruseva, L. Fossati-Jimack, D. Scott, T. Cook, M. Botto London, United Kingdom - W1.08.06 - Resident CD11b Ly6C lung dendritic cells are responsible for allergic airway sensitization to house dust mite in mice C. Mesnil, C.M. Sabatel, T. Marichal, M. Toussaint, D. Cataldo, P. Drion, P. Lekeux, F. Bureau, Christophe J. Desmet Liège, Belgium W7.02 - SYSTEMS AND THEORETICAL IMMUNOLOGY Chair: Kendall A. Smith (USA) W7.02.01 - Methodological applications of host-pathogen data profiles conserved in evolution Ariel L. Rivas, M.D. Jankowski, G. Leitner, D. Schwarz, J.M. Fair, A.L. Hoogesteijn, J.B. Hittner, J.M. Hyman, D.J. Perkins Albuquerque, USA 16.45-18.15 SPACE 4 15.10-16.40 BROWN 1 W1.08.04 - Unraveling the fingerprint of human tolerogenic DC-10, a dendritic cell subset involved in the establishment of peripheral tolerance M. Comi, D. Tomasoni, M. Villa, M. Pala, M. Floris, A. Bulfone, M. Roncarolo, Silvia Gregori Milan, Italy W1.16.05 - Role of the long Pentraxin PTX3 in fibrosarcoma development and progression Eduardo Bonavita, S. Gentile, N. Polentarutti, F. Feruglio, F. Pasqualini, M. Nebuloni, S. Jaillon, A. Mantovani, C. Garlanda Milan, Italy W7.02.03 - Functional proteomic interrogation of immune cell crosstalk and the effects of cytokine-targeted inhibitors using Single Cell Network Profiling D. Hotson, A. Conroy, A. Cesano, Rachael Hawtin San Francisco, USA W1.16.06 - Dendritic cell alternative pathway production is differentially regulated by interferons and IL27 Joseph O`Flynn, K. Dixon, N. Klar Mohamad, M.R. Daha, C. van Kooten Leiden, Netherlands W7.02.04 - Comparison of functional immune signalling profiles in peripheral blood mononuclear cells from rheumatoid arthritis patients versus healthy donors using Single Cell Network Profiling J. Ptacek, R. Hawtin, E. Evensen, J. Cordeiro, M. Atallah, C. Marimpietri, A. Cesano, TETRAD Investigators, P.K. Gregersen, S.Lou Bridges San Francisco, USA W6.08 - STEM CELLS IN IMMUNITY W7.02.05 - The role of microRNAs in regulatory T cell function C.Y. Brown, T. Sadlon, S. Pederson, G.T. Goodall, M. Beyer, J. Schultze, Simon C. Barry Adelaide, Australia Chairs: Luca Gattinoni (USA) Francesco Frassoni (ITA) 16.45-18.15 AMBER 1+2 15.10-16.40 BROWN 2 W1.16.03 - Response gene to complement-32 mediates C5b-9 induced cell cycle activation and migration in endothelial cells Cosmin A. Tegla, C.D. Cudrici, T. Ito, V. Nguyen, V. Rus, F. Niculescu, H. Rus Baltimore, USA W1.16.04 - Soluble GC1QR is an autocrine signal which induces bradykinin receptor 1 expression on activated endothelial cells Berhane Ghebrehiwet, Y. JI, K. Hosszu, A. Valentino, E.I.B. Peerschke Stony Brook, USA W7.02.02 - Higher expression of genes related to B cell activation in female spleen cells R. Godínez-Aguilar, E. Aguirre-von-Webesser, V. Bermúdez, E. Lamoyi, J. Berumen, José Moreno Cuernavaca, Mexico W7.02.06 - A bioinformatics pipeline to uncover regulatory modules and their condition-specific regulators in human monocyte-to-macrophages differentiation and polarization Emilia M.C. Mazza, P. Italiani, S. Valsoni, I. Cifola, D. Boraschi, C. Battaglia, S. Bicciato Modena, Italy W1.16.02 - Follicular dendritic cells are essential for maintenance of autoreactive B cells B.A. Heesters, P. Chatterjee, N. Dwivedi, A. Das, Michael C. Carroll Boston, USA IL6.08.01 - Harnessing stem-cell like memory T cells for adoptive cell transfer therapy of cancer Luca Gattinoni Bethesda, United States W6.08.01 - Potential roles for adipose-derived mesenchymal stem cells in the regulation of the mucosal immune system in aging K. Aso, K. Kimura, K. Takagaki, T. Kobayashi, K. Oki, S. Sugimoto, H. Tanemura, N. Urushihata, J.R. McGhee, Kohtaro Fujihashi Birmingham, USA 57 W6.08.02 - Clinical effects of intraperitoneal mesenchymal stem cells and mesenchmal stem cells-derived neural progenitor cells in a chronic experimental model of multiple sclerosis Fateme Nasri, T. Kalantari, M.S. Mohtasebi, F. Taki, E. Kamali Sarvestani Shiraz, Islamic Republic of Iran 16.45-18.15 AMBER 1+2 W6.08.03 - IFN- impairs the self-renewal of hematopoietic stem cells during viral infection A.M. de Bruin, B. Hooibrink, Martijn A. Nolte Amsterdam, Netherlands 16.45-18.15 AMBER 3+4 Workshops August 25, 2013 W6.08.04 - Mouse compact bone derived mesenchymal stem cells supress airway inflammation in both chronic and acute murine asthma model I. Ogulur, G. Gurhan, A. Aksoy, G. Duruksu, D. Filinte, I. Barlan, E. Karaöz, Tunç Akkoç Istanbul, Turkey Chairs: Thomas Hunig (DEU) Dario Vignali (USA) IL5.06.01 - The CD28 superagonist TGN1412: After the storm Thomas Hünig Würzburg, Germany IL5.06.02 - Molecular Control of Treg Stability and Function Dario Vignali Memphis, United States W6.08.06 - The acquisition of immunomodulating properties by mouse mesenchymal stem cells in presence of IFN- is associated with a reduced expression of Nanog and alteration of their differentiation potential Tiziana Vigo, C. Procaccini, G. Matarese, S. Baranzini, N. Kerlero de Rosbo, A. Uccelli Genoa, Italy W5.06.01 - TRAF6 is essential for maintenance of regulatory T cells and suppression of Th2 type inflammation Go Muto, R. Morita, S. Niikura, H. Kotani, T. Kobayashi, A. Yoshimura Tokyo, Japan 16.45-18.15 AMBER 3+4 W5.06.02 - Breakdown of immune tolerance by quantitative and qualitative alterations of ZAP-70 Atsushi Tanaka, S. Maeda, T. Nomura, S. Tanaka, L. Jin, S. Akizuki, N. Sakaguchi, R. Zamoyska, D.M. Standley, S. Sakaguchi Osaka, Japan W5.06.03 - KLRG1 expression in ICOS+Foxp3+ Treg cells delineates a functionally fatigued Treg subset during T1D progression in NOD mice Mara Kornete, C. Piccirillo Montreal, Canada W3.04.01 - A novel DNA break and phosphorylationdependent positive feedback loop promotes class switch recombination Jayanta Chaudhuri New York, USA W5.06.04 - B cell derived IFN- contributes to the negative regulation of T regulatory cell differentiation in arthritis Susan A. Olalekan, Y. Cao, T. Glant, A. Finnegan Chicago, USA W3.04.02 - AID-dependent IgV hypermutation requires a splice isoform of the SR protein SRSF1 Naoki Kanayama, Y. Kanehiro, K. Todo, Y. Kawaguchi, S. Miyazaki, K. Watanabe, H. Tokumitsu, J.L. Manley, M. Magari, H. Ohmori Okayama, Japan W5.06.05 - The in vivo impact of CD25 blockade on human regulatory T cells and evidence for compensatory maintenance by IL2R and IL7R signalling D. Huss, D. Mehta, A. Sharma, L. Amaravadi, J. Elkins, Jason D. Fontenot Cambridge, USA W3.04.03 - Effect of the 3’Regulatory Region insulation on B cell development and DNA rearrangements at the immunoglobulin heavy chain locus F. Braikia, Caroline Conte, M. Moutahir, A. Khamlichi Toulouse, France W5.06.06 - Restoration of normoglycemia in diabetic NOD mice by oral L. lactis secreting human pro-insulin plus IL-10 combined with short-term low-dose anti-CD3 is dependent on FOXP3+ Tregs Tatiana Takiishi, T. van Belle, S. Robert, H. Korf, P. Rottiers, C. Gysemans, C. Mathieu Leuven, Belgium W3.04.04 - Genetic variation and positional biases influence rearrangement of lymphocyte receptor genes Marie J. Kidd, A.M. Collins Kensington, Australia 58 16.45-18.15 AMBER 5+6 W3.04 - GENETIC REARRANGEMENTS OF LYMPHOCYTE RECEPTORS IL3.04.01 - Combinatorial H3K9acS10ph histone modifications in IgH locus S regions target 14-3-3 adaptors and AID to specify antibody class switch DNA recombination Paolo Casali, G. Li Irvine, United States W3.04.06 - The conservation of immunoglobulin genes: an evolutionary link between autoreactivity and innate response against pathogens André M. Vale, P. Kapoor, T.I. Mahmoud, C. Zemlin, M. Zemlin, P.D. Burrows, J.F. Kearney, D.E. Briles, A. Nobrega, H.W. Schroeder Rio de Janeiro, Brazil W5.06 - REGULATORY T CELLS IN AUTOIMMUNITY AND ALLERGY W6.08.05 - Allogenicity of human cardiac stem/progenitor cells orchestrated by programmed death ligand 1 (PD-L1) L. Lauden, W. Boukouaci, L.R. Borlado, I.P. López, P. Sepúlveda, R. Tamouza, D. Charron, Reem Al-Daccak Paris, France Chairs: Paolo Casali (USA) Roberto Sitia (ITA) W3.04.05 - Secondary immunoglobulin heavy chain rearrangements in IgA cloned mice Rashmi Kumar, O. Kanagawa, S. Fagarasan, S. Casola Milan, Italy Workshops August 25, 2013 W2.09 - MHC AND OTHER POLYMORPHIC GENES IN HEALTH AND DISEASE W1.07.04 - The inhibitory effect of secretory leukocyte protease inhibitor (SLPI) on formation of neutrophil extracellular traps Katarzyna Zabieglo, A. Wlodarczyk, M. Kapinska-Mrowiecka, A. Dubin, J. Cichy Krakow, Poland IL2.09.01 - MHC and other polymorphic genes in health and disease Jeffrey A. Frelinger, D. Jaraquemada Tucson, United States 16.45-18.15 AMBER 7+8 W2.09.01 - Tapasin facilitation of MHC-I separates closely related allomorphs, is strongly influenced by peptide length and depends on stability L. Geironson, C. Thuring, M. Harndahl, M. Rasmussen, S. Buus, G.A. Røder, Kajsa M. Paulsson Lund, Sweden 16.45-18.15 BROWN 1 Chairs: Jeoffrey A. Frelinger (USA) Dolores Jaraquemada (ESP) W2.09.02 - NLRC5 controls basal MHC class I gene expression in an MHC-enhanceosome dependent manner A. Neerincx, G. Rodriguez, V. Steimle, Thomas Kufer Köln, Germany W7.03 - STRUCTURAL BIOLOGY IN IMMUNOLOGY Chairs: Mette M. Rosenkilde (DEN) Stephanie Gras (AUS) W2.09.04 - Usage of a genome-wide shRNA-based lentiviral screen and targeted siRNA knockdown to identify host cell proteins involved in US2- and US11mediated degradation of MHC-I molecules Daniel C. Chapman, P. Stocki, F. Teusel, D.B. Williams Toronto, Canada IL7.03.01 - Structural basis of viral escape in Influenza Stephanie Gras, S. Valkenburg, C. Guillonneau, L. Hatton, K. Twist, A. Purcell, P. Doherty, J. Rossjohn, S. Turner, K. Kedzierska Clayton, Australia W2.09.05 - Comparative analysis of DQA1*05/DQB1*02 mRNAs and DQ2 heterodimer expression in relation to antigen presentation L. Pisapia, A. Camarca, P. Barba, S. Picascia, G. Del Pozzo, Carmen Gianfrani Avellino, Italy 16.45-18.15 BROWN 1 Chairs: William M. Nauseef (USA) Philip M. Murphy (USA) W1.07.01 - STIM2 is the essential STIM protein in nonSOCE calcium responses of macrophages in vitro and in vivo Georgios Sogkas, S. Syed, E. Rau, D. Stegner, T. Vögtle, B. Nieswandt, R. Schmidt, E. Gessner Hannover, Germany W1.07.02 - Glomerular deposition of myeloperoxidase and NETs in human anti ANCA associated vasculitis correlates with DTH effector cell accumulation Kim M. O’Sullivan, S.L. Ford, C. Lo, A.R. Kitching, S.R. Holdsworth Melbourne, Australia W1.07.03 - Leishmania inhibits antigen crosspresentation by cleaving VAMP8 N. Moradin, D. Matheoud, M. Desjardins, Albert Descoteaux Laval, Canada W7.03.01 - Crystal structure of adenovirus E3-19K protein bound to HLA-A2 reveals mechanism for immunomodulation L. Li, Y. Muzahim, Marlene Bouvier Chicago, USA 16.45-18.15 BROWN 2 W1.07 - EFFECTORS FUNCTIONS OF PHAGOCYTES (JOINT WITH SOCIETY OF LEUKOCYTE BIOLOGY) W1.07.06 - FAM19A4: a novel cytokine promotes phagocytosis of zymosan but negatively regulates TNF secretion associated with NF-B pathway in macrophages. Wenyan Wang, P. Wang, T. Li, X. Wang, W. Yuan, H. Zhang, Y. Zhang, D. Ma, W. Han Beijing, China Discussion W2.09.03 - TAPBPR uses the same residues as tapasin to associate with MHC-I Clemens Hermann, L.M. Strittmatter, L.H. Boyle Cambridge, United Kingdom W2.09.06 - Novel HLA-B27-restricted epitopes from Chlamydia trachomatis suggest a role of molecular mimicry in reactive arthritis Carlos Alvarez-Navarro, J. Cragnolini, H. G. Dos Santos, E. Barnea, A. Admon, A. Morreale, J. López de Castro Madrid, Spain W1.07.05 - The role of iRhom2 (rhbdf2) during immune activation Philipp A. Lang, D.R. McIlwain, D. Häussinger, K. Lang, P.S. Ohashi, T. Maretzky, P. Darshinee, J. Salmon, C.P. Blobel, T.W. Mak Dusseldorf, Germany W7.03.02 - Structural insight into HLA DQ8 restricted TCR selection in celiac disease Jan Petersen, S.E. Broughton, A. Theodossis, A. Thompson, J. van Bergen, Y. Kooy-Winkelaar, R.P. Anderson, F. Koning, H.H. Reid, J. Rossjohn Clayton, Australia W7.03.03 - Divergent T Cell recognition of a lengthy epitope bound to MHC-I molecule Yu-Chih Liu Clayton, Australia W7.03.04 - The constant region affects antigen binding of antibodies to DNA by altering secondary structure Y. Xia, A. Janda, E. Eryilmaz, A. Casadevall, Chaim Putterman Bronx, USA W7.03.05 - Structural insight on the recognition of surface-bound opsonins by the integrin I-domain of complement receptor 3 Goran Bajic, L. Yatime, T. Vorup-Jensen, G.R. Andersen Aarhus, Denmark W7.03.06 - Structural insights into S100 proteins recognition and signal transduction by the Receptor for Advanced Glycation End-products (RAGE) Laure Yatime, G.R. Andersen Aarhus, Denmark 59 Chair: Fiona Powrie (GBR) Tadamitsu Kishimoto (JPN) IL-6: new era comes for the treatment of inflammatory autoimmune diseases Chair: Andrea Velardi (ITA) Max D. Cooper (USA) Evolution of adaptive immunity Chair: Anne O’Garra (GBR) Klaus Rajewsky (DEU) Modeling Epstein-Barr virus pathologies, immune surveillance and human lymphomas in mice LL.26 - LUNCHTIME LECTURE Chair: Vincenzo Barnaba (ITA) Matthew Albert (FRA) Chemokine antagonism: an in vivo mechanism for regulating inflammation during viral infection and tumorigenesis LL.28 - LUNCHTIME LECTURE Chair: Olja Finn (USA) Riccardo Dalla Favera (USA) Genetic determinants of B cell lymphoma transformation and immune escape 12.30 - 13.15 BROWN 3 LL.24 - LUNCHTIME LECTURE 12.30 - 13.15 SPACE 4 Chair: James Allison (USA) Giorgio Trinchieri (USA) The role of the commensal microbiota in regulating inflammation and cancer 12.30 - 13.15 SPACE 1+2 Chair: Marco Colonna (USA) Diane J. Mathis (USA) AIRE control of immunological tolerance: new twists LL.22 - LUNCHTIME LECTURE 18.30 - 19.15 GOLD ROOM PS.08 - PERSPECTIVES IN IMMUNOLOGY PL.07 - PLENARY LECTURE 12.30 - 13.15 AMBER 3+4 12.30 - 13.15 GOLD ROOM 12.30 - 13.15 BROWN 1+2 12.30 - 13.15 SPACE 3 12.30 - 13.15 AMBER 1+2 60 8.50 - 9.20 SPACE 1+2 PS.07 - PERSPECTIVES IN IMMUNOLOGY 9.30 - 10.15 GOLD ROOM 8.50 - 9.20 GOLD ROOM Main Lectures August 26, 2013 LL.23 - LUNCHTIME LECTURE Chair: Maria Rescigno (ITA) Fiona Powrie (GBR) Gut reactions: immune pathways that control intestinal homeostatis LL.25 - LUNCHTIME LECTURE Chair: Dmitry Gabrilovich (USA) Frederic Geissmann (GBR) Differentiation and functions of monocytes/macrophages LL.27 - LUNCHTIME LECTURE Chair: Attila Mocsai (HUN) John J. O'Shea (USA) Helper cell specification: cytokines, transcription factors and the epigenome LL.29 - LUNCHTIME LECTURE Chair: Riccardo Gazzinelli (BRA) Alan Sher (USA) IL-1 mediates host resistance to Mycobacterium tuberculosis through an eicosanoid pathway PL.08 - PLENARY LECTURE Chair: William Paul (USA) Richard A. Flavell (USA) The inflammasome in health and disease Parallel Symposia August 26, 2013 Chairs: Anne Ostergaard (CAN) Wolf H. Fridman (FRA) Jerome Galon (FRA) S19.01 From the immune contexture to the immunoscore in the era of cancer immunotherapy Gabriel Rabinovich (ARG) S19.02 Regulatory circuits in autoimmunity and cancer mediated by lectins and glycans Mario Colombo (ITA) S19.03 Neutrophils bridges autoimmunity and cancer Vincenzo Bronte (ITA) S19.04 Molecular regulation of innate immunity in tumor microenvironment Dmitry I. Gabrilovich (USA) S19.05 Myeloid-derived suppressor cells in regulation of immune responses in cancer S20 - T AND B CELL SUBSETS 10.20 - 12.25 SPACE 1+2 10.20 - 12.25 GOLD ROOM S19 - IMMUNE SURVEILLANCE AND TUMOR IMMUNITY S22 - COSTIMULATORY AND INHIBITORY MOLECULES 10.20 - 12.25 BROWN 3 10.20 - 12.25 BROWN 1+2 S21 - NK CELLS Chairs: Klas Kärre (SWE) Hans Gustaf Ljunggren (SWE) Wayne M. Yokoyama (USA) S21.01 NK cell biology in innate immunity Miguel Lopez-Botet (ESP) S21.02 Adaptive reconfiguration of the human NK-cell compartment in response to cytomegalovirus Angela Santoni (ITA) S21.03 NK cell-mediated immune surveillance of senescent cells Eric Vivier (FRA) S21.04 Natural killer cells, innate lymphoid cells and Immunity Bruno Silva-Santos (POR) S21.05 Molecular mechanisms of differentiation of gamma-delta T lymphocytes 10.20 - 12.25 SPACE 4 10.20 - 12.25 SPACE 3 Chairs: Susan Swain (USA) Ronald H. Schwartz (USA) Yong-Jun Liu (USA) S22.01 Targeting OX40 to block Treg in Cancer David Sansom (GBR) S22.02 The role of CTLA-4 in regulating T cell responses Mauro Perretti (GBR) S22.03 Neutrophil micro particles activates tissue protective signals Massimo Locati (ITA) S22.04 Immune function and mechanism of action of atypical chemokine receptors Arlene Sharpe (USA) S22.05 The multifaceted functions of the PD-1 pathway in controlling T cell activation and tolerance S24 - PROTOZOAL, FUNGAL AND HELMINTH INFECTIONS S23 - VACCINATION Chairs: Giuseppe Del Giudice (ITA) Oliver O. Perez (CUB) Julie Magarian Blander (USA) S23.01 Vita-PAMPs: signatures of microbial viability Robert L. Coffman (USA) S23.02 Development of TLR9 agonists as vaccine adjuvants Adrian Hill (GBR) S23.03 Progress with T cell inducing vaccines against intracellular pathogens Jorge Kalil (BRA) S23.04 From molecular immunopathogenesis of rheumatic fever to the development of a vaccine against streptococcus pyogenes Karolina Palucka (USA) S23.05 Reprogramming the immune environment in cancer via dendritic cells Chairs: Tim R. Mosmann (USA) Kenneth M. Murphy (USA) William E. Paul (USA) S20.01 Cytokines and CD4 T cells: dance partners at the immunology ball Vijay K. Kuchroo (USA) S20.02 Transcriptional network controlling Th17 development Francesco Annunziato (ITA) S20.03 Epigenetic mechanisms in the regulation of human Th17 plasticity Alexander Y. Rudensky (USA) S20.04 Regulatory T cells in control of inflammation Kenneth M. Murphy (USA) S20.05 Development and function of dendritic cell subsets Chairs: Kenji Nakanishi (JPN) Luigina Romani (ITA) Rick Maizels (GBR) S24.01 Impact of helminth parasites on immune regulation and immunity Douglas Golenbock (USA) S24.02 DNA drives innate immune responses in malaria Luigina Romani (ITA) S24.03 The host-mycobioma interactions in health and diseases Judith Allen (GBR) S24.04 Macrophage activation and function during helminth infection Mauro Teixeira (BRA) S24.05 Can we develop anti-inflammatory drugs for infectious diseases? 61 Sponsored Sessions August 26, 2013 MOVING TRANSLATIONAL IMMUNOLOGY FORWARD THROUGH PUBLIC-PRIVATE PARTNERSHIP 15.10 - 16.40 SPACE 1 with the contribution of IMI - Innovative Medicine Initiative Chair: Luciano Adorini (ITA) Michel Goldman (BLG) IMI: opportunities and challenges for immunologists Jeffrey A. Bluestone (USA) Advancing drug discovery through academic-industry partnerships: the UCSF experience Marc Feldmann (GBR) Translating inflammatory understanding towards patient benefit Paul-Peter Tak (GBR) Open innovation: a new paradigm for industry-academia collaboration MODULATION OF IMMUNE SUPPRESSIVE NETWORK TO ENHANCE CANCER IMMUNOTHERAPY. RECENT ADVANCES AND NEW CHALLENGES 15.10 - 16.40 SPACE 3 with the contribution of Genentech Chairs: Dmitry Gabrilovich (USA), Vincenzo Bronte (ITA) Nicholas Restifo (USA) Ablating/reprogramming aberrant immunity in the tumor microenvironment Drew Pardoll (USA) TBD Francis Balkwill (GBR) CCR4 and its ligands in renal cancer TARGETING IL-12/IL-23 IN CHRONIC INFLAMMATORY DISEASES: THE PSORIATIC SPECTRUM PARADIGM 15.10 - 16.40 SPACE 4 with the contribution of Janssen Pharmaceutica NV 62 Chair: Carlo Selmi (ITA) Andreas Radbruch (DEU) The role of IL-12/IL-23 in T Cell differentiation Emilio Berti (ITA) Immunopathological correlates in the pathogenesis of psoriatic diseases Gianpiero Girolomoni (ITA) Psoriasis as a testing ground for novel biologicals: targeting IL-12/IL-23 Pierluigi Meroni (ITA) New therapies for psoriatic arthritis: targeting IL-12/IL-23 and beyond Workshops August 26, 2013 W5.20.10 - Density of tertiary lymphoid structures predicts T cell infiltration with coordinated Th1 polarization and cytotoxic effectors functions in human lung cancer Jérémy Goc, L. de Chaisemartin, A. Lupo, D. Damotte, P. Validire, D. Vo-Bourgais, P. Devi, W. Fridman, C. SautèsFridman, M. Dieu-Nosjean Paris, France W5.20 - TUMOR IMMUNITY AND IMMUNOSURVEILLANCE Chairs: Ron Apte (ISR) Shubhda Chiplunkar (IND) IL5.20.02 - Notch regulates anti tumor functions of gamma delta T cells in oral cancer Shubhada Chiplunkar, D. Gogoi, D. Chaukar, A. D’Cruz Kharghar, Navi Mumbai, India W5.20.01 - CD70 reverse signalling on NK cells enhances anti-tumoral immune response Mohamad Al Sayed, C. Riether, C. Schürch, A. Ochsenbein Bern, Switzerland 15.10-18.15 GOLD ROOM IL5.20.01 - IL-1 is a major inflammatory cytokine that mediates the angiogenic switch in tumor invasiveness Ron N. Apte, Y. Carmi, S. Dotan, I. Kaplanov, Z. Shavshkevitz, C.A. Dinarello, E. Voronov Beer Sheva, Israel W1.09 - DENDRITIC CELL DIFFERENTIATION AND FUNCTION W5.20.04 - MicroRNA-9 regulates maturation and function of myeloid-derived suppressor cells by modulating Runx1 Jie Tian, Y. Zhang, X. Tian, K. Rui, X. Tang, S. Wang Zhenjiang, China Chairs: Guido Ferlazzo (ITA) Pamela Ohashi (CAN) IL1.09.01 - Dendritic cells identified in the human system Guido Ferlazzo Messina, Italy W5.20.05 - Neuropilin-1 guides regulatory T cells into tumor tissues resulting in impaired anti-tumor immunity Wiebke Hansen, M. Hutzler, I. Helfrich, J. Buer Essen, Germany W5.20.08 - Active STAT5 imprints a T-Bet-dependent Tc-1 program in CD8 T cells inducing efficient regression of autochthonous melanoma M. Grange, G. Verdeil, A. Schmitt-Verhulst, Nathalie Auphan-Anezin Marseille, France W5.20.09 - T cells from DNAM-1 deficient mice display polarity defects that impair anti-tumour immunity Jane Oliaro, K. Ramsbottom, S. Russell, M. Smyth Melbourne, Australia IL1.09.02 - Molecular regulators of DC function Pamela S. Ohashi, E.F. Lind, D. Johnson, D. Dissanayake Toronto, Canada 15.10-18.15 BROWN 3 15.10-18.15 GOLD ROOM W5.20.14 - Evaluating parameters that influence T cell responses to tumor antigens: A role for B7-H4 Ramtin Rahbar, A. Lin, M. Ghazarian, T. Mak, P. Ohashi Toronto, Canada W5.20.03 - Predictive clinical significance of tumor infiltrating neutrophils in patients with colorectal cancer Maria Rosaria R. Galdiero, F. Grizzi, G. Di Caro, L. Laghi, C. Garlanda, A. Mantovani, S. Jaillon Milan, Italy W5.20.07 - Complement dependent immunosurveillance in Her-2/neu autochtonous carcinomas arising in BALB-neuT transgenic mice Silvio Bandini, C. Curcio, M. Macagno, M. Iezzi, F. Cavallo Torino, Italy W5.20.12 - The BCR regulates Burkitt lymphoma survival and proliferation through the modulation of GSK3 activity Gabriele Varano, S. Raffel, F. Zanardi, K. Rajewsky, S. Casola Milan, Italy W5.20.13 - Inhibiting the development of immunosuppressive Gr-1+ dendritic cells in tumors by blokking TLR2 enhances immunotherapy Michael Tang Toronto, Canada W5.20.02 - BRAF inhibitor impacts on melanoma cell immunogenicity Emmanuelle Fourmentraux-Neves, M. Messaoudene, C. Nicolaizeau, M. Avril, K. Belkhiria, A. Savina, A. Caignard Paris, France W5.20.06 - A novel self-lipid antigen targets human T cells against CD1c+ leukemias Claudia de Lalla, M. Lepore, G. Ramanjaneyulu, D. Montagna, F. Locatelli, F. Ciceri, L. Mori, P. Dellabona, G. De Libero, G. Casorati Milan, Italy W5.20.11 - Galectin-3 is involved in the immunosuppressive activity of prostate cancer stem cells Chiara Svetlana Brambillasca, E. Jachetti, M. Grioni, S. Mazzoleni, M. Freschi, R. Galli, M. Bellone Milan, Italy W1.09.01 - Defining dendritic cells by ontogeny Barbara Schraml, J. van Blijswijk, S. Zelenay, P. Whitney, A. Filby, N. Rogers, C. Reis e Sousa London, United Kingdom W1.09.02 - Lymphatic endothelium forms integrin-engaging 3D structures during DC transit across inflamed lymphatic vessels Álvaro Teijeira, S. Garasa, R. Pelaez, C. Aubá, C. Alfaro, R. Magda, S. Vallituti, R. Ana, M. Ignacio Pamplona, Spain W1.09.03 - MyD88 signalling drives steady-state intestinal CD103+ DC migration to draining mesenteric lymph nodes Karin Hägerbrand, B. Johansson-Lindbom, W. Agace Lund, Sweden W1.09.04 - IL-27 in human secondary lymphoid organs attracts myeloid DC and impairs their HLA class I-restricted antigen processing and presentation Fabio Morandi, E. Di Carlo, S. Ferrone, V. Pistoia, I. Airoldi Genoa, Italy 63 Workshops August 26, 2013 W4.08 - IMMUNITY TO PROTOZOAN PARASITE INFECTION 15.10-18.15 BROWN 3 W1.09.05 - The kindlin-3-beta2 integrin interaction controls DC activation and Th1/Th2 priming Vicky L. Morrison, M. MacPherson, K. Grzes, P. Cook, C. Gawden-Bone, A. Prescott, A.S. MacDonald, S.C. Fagerholm Dundee, United Kingdom Chairs: Franck Brombacher (ZAF) Nick W. Lukacs (USA) W1.09.07 - Chronic hypoxia reprograms human immature DCs by inducing a proinflammatory phenotype and TREM-1 expression Daniele Pierobon, M.C. Bosco, F. Blengio, F. Raggi, A. Eva, T. Musso, F. Novelli, P. Cappello, L. Varesio, M. Giovarelli Turin, Italy W4.08.02 - Recognition of Leishmania parasites by the macrophage-inducible C-type lectin Mincle subverts adaptive immunity and promotes susceptibility to infection Salvador Iborra, H. Izquierdo, N. Enamorado, R. Conde, R. Reguera, M. Soto, D. Sancho Madrid, Spain W1.09.08 - The mitochondrial protein, TCAIM, abolishes T cell priming of DCs by inhibiting TLR-induced IL-2 expression Simone Vogel, S. Schlickeiser, I. Panov, M. Schröder, M. Lutz, K. Vogt, G. Grütz, B. Sawitzki Berlin, Germany W4.08.03 - Marginal zone B-cells suppress antigenspecific T-cell responses during experimental L. donovani infection R. Bankoti, K. Gupta, Simona Stager Laval, Canada W1.09.09 - PAF induces regulatory DCs through two independent mechanisms: amplification of COX2/PGE2 loop and induction of IL10 Marianna M. Koga, F.J.O. Rios, B. Bizzarro, A. Sá-Nunes, S. Jancar Sao Paulo, Brazil 15.10-16.40 SPACE 2 W1.09.06 - Deletion of IL-4 receptor alpha on DCs renders mice hypersusceptible to Leishmania major infection Frank Brombacher Cape Town, South Africa W4.08.01 - Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection Ramona Hurdayal, N.E. Nieuwenhuizen, M. Revaz-Breton, L. Smith, J.C. Hoving, S.P. Parihar, B. Reizis, F. Brombacher Cape Town, South Africa W1.09.10 - Glucocorticoid-Induced Leucine Zipper expression in DCs controls Treg induction in vivo Joseph Calmette, T. Tran, S. Karaki, M. Ellouze, M. Pallardy, F. Bachelerie, R. Krzysiek, D. Emilie, G. Schlecht-Louf, V. Godot Clamart, France W4.08.05 - Protective CD8+ T effector memory cells elicited by heterologous prime-boost vaccination expand and re-circulate after an infectious challenge with Trypanosoma cruzi J.R. Vasconcelos, Mariana Ribeiro Dominguez, R. Lemos, L.I. Santos, F. Virgilio, A.V. Machado, O. BrunaRomero, R.T. Gazzinelli, M.M. Rodrigues São Paulo, Brazil W1.09.11 - The inhibitory NK receptor Ly49Q protects plasmacytoid dendritic cells from TLR9-triggering cell death by assuring lysosomal integrity Noriko Toyama-Sorimachi, M. Tanaka, T. Kobayashi, A.P. Makrigiannis, K. Inaba Tokyo, Japan W4.08.06 - Immunological mechanisms of co-infection of schistosomiasis and malaria in a primate model Ruth K. Nyakundi, J. Maamun, M. Akinyi, O. Nyamongo, I. Mulei, H. Ozwara, I.O. Farah, I. Malhotra, C.L. King, T. Kariuki Nairobi, Kenya W1.09.12 - Membrane transfer from tumor cells generates plasmacytoid dendritic cells cross-dressed with exogenous antigens Irene Bonaccorsi, B. Morandi, G. Costa, D. Oliveri, R. Conte, G. Pezzino, M. Mingari, G. Ferlazzo Messina, Italy W1.09.14 - Dendritic cells partake in regulation of ovarian physiology Adva Cohen-Fredarow, A. Tadmor, T. Raz, N. Meterani, M. Neemam, G. Mor, N. Dekel Rehovot, Israel 64 W4.07 - IMMUNITY TO HELMINTH INFECTION Chairs: Shigeo Koyasu (JPN) Anne La Flamme (NZL) 15.10-16.40 AMBER 1+2 W1.09.13 - Myeloid cells in the islets of Langerhans are key players in presentation of islet antigens and trophic function: identification of their phenotype and ontogeny Boris Calderon, E.R. Unanue St. Louis, USA W4.08.04 - Cellular immune polarization to a cell phenotype Th-1 and T-Reg is induced after the treatment of human dendritic cells infected by Leishmania with the compound 11,19-dihydroxy-7-acetoxy-7-deoxoichangin Gabriela Delgado, D. Granados-Falla, C. Coy-Barrera, L. Cuca Bogota, Colombia IL4.07.01 - Driving disease outcome in schistosomiasis: correlating antibody to disease severity Anne C. La Flamme, B. Manivannan, J. Jaurigue, T.W. Jordan, W.E. Secor, B. Doughty Wellington, New Zealand W4.07.01 - CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis Holly E. Ponichtera, R. Raychowdhury, M.G. Shainheit, J.M. Russo, B.M. Larkin, D.B. Salantes, S.C. Bunnell, N. Hacohen, M.J. Stadecker Boston, USA W4.07.02 - Immunological changes in epidermal keratinocytes following infection with schistosome cercariae Claire D. Bourke, A.P. Mountford York, United Kingdom Chairs: Daniela Frasca (USA) Scheherazade Sadegh-Nasseri (USA) W4.07.04 - Innate and adaptive IL-9 orchestrate type 2 immunity Paula Licona-Limón, J. Henao-Mejía, N. Gagliani, I. Licona-Limón, D.R. Herbert, R.A. Flavell New Haven, USA IL2.05.01 - Genetic Regulation of Longevity in Memory CD4 T cells in Aged mice Scheherazade Sadegh-Nasseri, S. Khoruzhenko, N. Song, S. Sonder Baltimore, United States W4.07.05 - Mechanisms of the lymphocyte hypo-responsiveness after repeated exposure of the skin to Schistosoma mansoni cercariae Catriona T. Prendergast, P. Cook, A. Mountford York, United Kingdom W4.07.06 - IL-10 secreting, type 1 regulatory T cells and naturally occurring regulatory T cells differently modulate IgG secretion by B cells in human hypo-responsive onchocerciasis Tomabu Adjobimey, C. von Horn, J. Satoguina, J. Oldenburg, L. Layland, A. Hoerauf Bonn, Germany W6.09 - VACCINE ADJUVANTS Chairs: Paola Parronchi (ITA) Ali Harandi (SWE) W2.05.01 - Characterization of the role of distinct plasma cell-free DNA (cf-DNA) species in age-associated inflammation and frailty Juulia Jylhävä Tampere, Finland IL6.09.01 - Vaccine adjuvants for mucosal immunity: recent progress and future challenges Ali Harandi Gothenburg, Sweden W2.05.06 - Human B cell response to the influenza vaccine is predicted by AID and decreased by inflammaging Bonnie B. Blomberg, A. Diaz, M. Romero, A. Landin, D. Frasca Miami, USA W6.09.02 - Using immunopotentiating capacity of flagellin for sublingual immunotherapy Natalia Muñoz-Wolf, A. Rial, J.M. Saavedra, J. Tabareau, D. Fougeron, J.M. Marqués, J. Sirard, J.A. Chabalgoity Montevideo, Uruguay W6.09.03 - A Dectin-1-assisted APC-targeting TLR9agonist as an adjuvant Kouji Kobiyama, K.J. Ishii Ibaraki, Japan W7.05 - EVOLUTION OF THE IMMUNE SYSTEM AND COMPARATIVE IMMUNOLOGY 15.10-16.40 AMBER 7+8 15.10-16.40 AMBER 3+4 W2.05.03 - Assessing human TCR CDR3 repertoire by a RACE-PCR-sequencing method H. Li, T. Hiroi, Y. Zhang, G. Chen, S. De, E.J. Metter, W.H. Wood III, K.G. Becker, Nan-ping P. Wenig Baltimore, USA W2.05.05 - Memory immune response to booster vaccination in old age depends on adequate priming earlier in life Birgit Weinberger, C. Neuner, M. Schirmer, R. Mateucci Gothe, B. Grubeck-Loebenstein Innsbruck, Austria W6.09.01 - Novel adjuvants for DNA vaccines Tamsin Gargett, T. Garrod, B. Grubor-Bauk, W. Yu, D. Miller, L. Major, S. Wesselingh, A. Suhrbier, E. Gowans Adelaide, Australia W6.09.05 - Antigen trafficking within lymphoid organs and humoral immune response: The effect of MF59 adjuvant Rocco Cantisani, A. Pezzicoli, C. Malzone, A. Seubert, F. Giusti, U. D’Oro, E. De Gregorio, M. Carroll, D. Piccioli Siena, Italy W2.05.02 - Senescence associated cells in human CD8+ T-lymphocytes Oscar O. Onyema, L.N. Forti, R. Njemini, I. Bautmans, J. Aerts, M. De Waele, T. Mets Brussel, Belgium W2.05.04 - Memory B cell repertoire changes with age Deborah K. Dunn-Walters. London, United Kingdom IL6.09.02 - Perspectives in vaccine adjuvants Paola Parronchi, L. Filì, E. Cardilicchia Firenze, Italy W6.09.04 - Adjuvants are the future of vaccine formulation. The case of Finlay adjuvants Oliver Pérez, M. Lastre, B. Romeu, O. Cabrera, M. Cuello, E. González, A. Batista-Duharte, A. Labrada, W. Ramírez, R. Nicado Havana, Cuba W6.09.06 - SBA-15 nanostructured silica adjuvant enhances immune responsiveness and modulates sensibility to bacterial toxins Karina Scaramuzzi, G.D. Tanaka, M. Tino De Franco, A.G. Trezena, O.A. Sant Anna Sao Paulo, Brazil W2.05 - IMMUNE RESPONSES IN AGING 15.10-16.40 AMBER 5+6 15.10-16.40 AMBER 1+2 W4.07.03 - Basophils contribute to the Th2-type protective immunity against re-infection with intestinal helminths Kazushige Obata-Ninomiya, H. Tsutsui, K. Ishiwata, N. Watanabe, H. Kanuka, H. Karasuyama Tokyo, Japan 15.10-16.40 AMBER 3+4 Workshops August 26, 2013 Chairs: Michael JH Ratcliffe (CAN) Loriano Ballarin (ITA) IL7.05.01 - Antigen Mediated Positive and Negative Selection of Developing Chicken B Cells Michael J.H. Ratcliffe, D. Davani Toronto, Canada IL7.05.02 - Phenoloxidases and cytotoxicity in ascidians: an overview Loriano Ballarin, N. Franchi, F. Schiavon, S.C.E. Tosatto Padova, Italy 65 Workshops August 26, 2013 15.10-16.40 AMBER 7+8 W7.05.02 - Atlantic cod displays an unusual TLR repertoire: A Gadidae-specific feature? Monica H. Solbakken, M. Malmstroem, O. Toerresen, K.S. Jakobsen, S. Jentoft Oslo, Norway W7.05.03 - Evolution of antigen recognition by V9V2 T cells Mohindar Murugesh Karunakaran, L. Starick, L. Walter, T. Goebel, T. Herrmann Wuerzburg, Germany 15.10-16.40 BROWN 1 W7.05.01 - Generation of B lymphocytes and immunoglobulin diversity in Bos taurus J. Liljavirta, A. Ekman, Mikael Niku, T. Pessa-Morikawa, A. Iivanainen Helsinki, Finland W5.18 - INFLAMMATORY BOWEL DISEASES Chairs: Silvio Danese (ITA) Fabio Cominelli (USA) W7.05.05 - Phenoloxidases and cytotoxicity in ascidians: An overview Ballarin Loriano, N. Franchi, F. Schiavon, S.C.E. Tosatto Padua, Italy W5.18.01 - Depletion of regulatory T cells improves anti-tumour immunity in colitis-associated colon cancer E. Pastille, K. Schumann, D. Fleissner, W. Hansen, T. Sparwasser, J. Buer, Astrid M. Westendorf Essen, Germany W7.05.06 - The secondary structure of the pre-mRNA encoding the antarctic fish Ig chain drives its atypical splicing pattern Stefano Giacomelli, S. Varriale, U. Oreste, M. Coscia Naples, Italy W5.18.02 - RIP3 promotes injury-induced cytokine expression and tissue repair Kenta Moriwaki, F.K. Chan Worcester, USA W3.06 - COSTIMULATION 15.10-16.40 BROWN 1 W3.06.01 - Mechanical insights into the functional impacts of interactions between antigen-presenting cells and T cells T.S. Lim, A. Mortellaro, C. Lim, G. J. Hämmerling, Mariana Paola Ricciardi-Castagnoli Singapore, Singapore W3.06.02 - Basilic, a lymphoid-specific protein essential for CD28 costimulation and regulatory T cell development Marie Malissen, L. Yinming, M. Cucchetti, R. Roncagalli, T. Yokosuka, T. Saito, C. Wuelfing, B. Malissen Marseille, France W3.06.03 - Human memory T cell subsets require distinct costimulatory signals to efficiently expand ex vivo Valentina Volpin, N. Cieri, C. Bonini Milan, Italy 66 15.10-16.40 BROWN 2 Chairs: Loretta Tuosto (ITA) Matthias Von Herrath (USA) IL3.06.02 - Viruses and type 1 diabetes - the good and the bad Matthias G. Von Herrath La Jolla and Seattle, United States W3.06.05 - PD-1 controls effectors but not the generation or function of natural or induced regulatory T cells Kristofor K. Ellestad, G. Thangavelu, C.L. Ewen, C.C. Anderson Edmonton, Canada W3.06.06 - Immunogenic, but not steady-state, antigen presentation permits Treg control of CD8+ T cell effector differentiation through IL-2 modulation Raymond J. Steptoe, A. McNally, R. Thomas Woolloongabba, Australia W7.05.04 - Drosophila Helical factor (Hf) and helical cytokine evolution: From in silico approaches to functional evidence Davide Malagoli Modena, Italy IL3.06.01 - Autonomous CD28 signalling pathways in the regulation of T lymphocyte survival and pro-inflammatory functions Loretta Tuosto Rome, Italy W3.06.04 - Differential usage of costimulatory /coinhhibitory pathways by antigen-specific CD8+ T cells in patients with chronic hepatitis C Solomon Owusu Sekyere, P. Suneetha, V. Schlaphoff, M. Manns, M. Cornberg, H. Wedemeyer Hannover, Germany W5.18.03 - Induction of IL-33 is dependent on the gut microflora and is essential for EOS activation/migration and Th2 immune responses in the pathogenesis of experimental IBD Carlo De Salvo, X. Wang, S. Chowdhry, D. Corridoni, F. Cominelli, J.J. Lee, W. Xin, T.T. Pizarro Cleveland, USA W5.18.04 - Targeting IL-23/TH17 axis to suppress intestinal inflammation in murine spontaneous colitis induced by an epithelial defect Ran Wang, S. Hasnain, H. Tong, I. Das, A. Chen, T. Florin, R. Eri, M. McGuckin Brisbane, Australia W5.18.05 - The p50 NF-B subunit is a key orchestrator of cancer-related intestinal inflammation Chiara Porta, L. Carraro, M.G. Totaro, M. Rimoldi, F. Pasqualini, M. Nebuloni, A. Sica Novara, Italy W5.18.06 - Novel HLA-DR transgenic mice that spontaneously develop colitis with serious defects in lymphoid organs Atsushi Irie, J. Yatsuda, Y. Michibata, T. Kubo, T. Imamura, N. Takeda, I. Shibuya, S. Sogo, Y. Nishimura Kumamoto, Japan Workshops August 26, 2013 W2.08 - ANTIGEN RECEPTOR SIGNALING W4.09.02 - Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome Katrien Deroost, A. Tyberghein, N. Lays, E. Schwarzer, M. Komuta, M. Prato, P. Arese, D. Daelemans, G. Opdenakker, P.E. Van den Stehen Leuven, Belgium Chairs: Yvonne Rosenstein (MEX) Alberto Amadori (ITA) 16.45-18.15 SPACE 1 W2.08.01 - Antigen-specific TCR-pMHC catch bond enables force to trigger T cell signalling Cheng Zhu, B. Liu, W. Chen, B. Evavold Atlanta, USA W2.08.02 - Regulation of the Ras-Erk cascade during T-cell activation. Mateusz Poltorak, B. Schraven, L. Simeoni Magdeburg, Germany 16.45-18.15 SPACE 2 IL2.08.01 - Novel assignments for the CD43 molecule M.E. Bravo-Adame, M. Sandoval-Hernández, N.A. Fierro, E. Pérez-Rueda, J. Carneiro, R. Vera, B. Barkla, M.E. CruzMunoz, Yvonne Rosenstein Cuernavaca, Mexico W2.08.03 - Kidins220/ARMS associates with B-Raf and the TCR promoting sustained Erk signalling in T cells Gina J. Fiala, S. Deswal, A. Meyer, A.E. Eisenhardt, L.C. Schmitt, M. Salek, T. Brummer, O. Acuto, S. Minguet, W.W.A. Schamel Freiburg, Germany W4.09.06 - Progress towards a broadly neutralizing vaccine against the asexual blood-stage of Plasmodium falciparum Alexander D. Douglas, A.R. Williams, J.J. Illingworth, K. Hjerrild, S.J. Draper Oxford, United Kingdom W2.08.05 - Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signalling and antibody response Raul M. Torres, J. Hu, S. Oda, A. Al-Shami, Y. Fujiwara, G. Tigyi, T. Oravecz, R. Pelanda Denver, USA W4.06 - IMMUNITY TO FUNGAL INFECTION Chairs: Vera Calich (BRA) Betty Wu-Hsieh (TWN) W2.08.06 - Negative regulation of chemokine receptor signalling and B cell chemotaxis by p66Shc Nagaja Capitani, L. Patrussi, E. Cannizzaro, F. Finetti, O. Lucherini, P. Pelicci, C.T. Baldari Siena, Italy IL4.09.01 - Malaria and its delectable mammalian organ - the liver Urszula Krzych, A.V. Pichugin, S.N. Zarling, O. Jobe Silver Spring, United States IL4.09.02 - Pathogenetic role of hemozoin (malaria pigment) in severe P. falciparum malaria N. Basilico, Y. Corbett, S. Parapini, S. D’Alessandro, D.P. Ilboudo, D. Scaccabarozzi, Donatella Taramelli Milano, Italy W4.09.01 - Antibodies to Plasmodium falciparum merozoite surface protein and neutrophil respiratory burst activity are associated with clinical outcome in severe urban malaria Babacar Mbengue Dakar, Senegal IL4.06.01 - The crucial role of indoleamine 2,3-dioxygenase (IDO) in the tolerogenic and immunogenic mechanisms against Paracoccidioides brasiliensis infection Vera L.G. Calich, E.F. Araújo São Paulo, Brazil 16.45-18.15 AMBER 1+2 16.45-18.15 SPACE 2 Chairs: Ursula Krzych (USA) Donatella Taramelli (ITA) W4.09.04 - Apolipoprotein E is critical for the development of cerebral malaria Fikregabrail A. Kassa, M. Olivier Montreal, Canada W4.09.05 - Validation of novel antigenic targets identified by whole-genome screening for next-generation malaria vaccines Sophie Schussek, A. Trieu, S.H. Apte, D.L. Doolan Brisbane, Australia W2.08.04 - Dual-specificity phosphatase 14 negatively regulates TAK1 signalling and immune responses Chia-Yu Yang, T. Tan Miaoli County, Taiwan W4.09 - MALARIA PATHOGENESIS AND VACCINES W4.09.03 - IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals Ana Villegas-Mendez, B.J. de Souza, S. Lavelle, E.G. Findlay, T.N. Shaw, N. van Rooijen, C.J. Saris, C.A. Hunter, E.M. Riley, K.N. Couper Manchester, United Kingdom IL4.06.02 - Dectin-2 and NLRP3 Are Involved in Inflammasome Activation in Dendritic Cell Response to Histoplamsa Stimulation Betty Wu-Hsieh, T. Chang Taipei, Taiwan W4.06.01 - IL-17 regulates fungal immunity by controlling the functional competence of NK cells Eva Bär, S. LeibundGut-Landmann Zürich, Switzerland W4.06.02 - LAB/NTAL facilitates fungal/PAMP-induced IL-12 production and Th1 responses by repressing -catenin activation in dendritic cells Selinda J. Orr, A.R. Burg, L. Quigley, G.W. Jones, J.W. Ford, G.M. O’Connor, P.R. Taylor, G. Trinchieri, D.W. McVicar Cardiff, United Kingdom 67 16.45-18.15 AMBER 1+2 W4.06.03 - IL-33-dependent signalling regulates innate and adaptive immunity following pulmonary Cryptococcus neoformans infection Adam Flaczyk, C.U. Duerr, M. Shourian, E.I. Lafferty, J.H. Fritz, S.T. Qureshi Montreal, Canada W4.06.04 - Pathogen recognition by the long pentraxin PTX3: fine tuning by protein glycosylation Antonio Inforzato, M. Sironi, S. Valentino, B. Bottazzi, A. Mantovani Milan, Italy 16.45-18.15 AMBER 3+4 Workshops August 26, 2013 W4.06.05 - Enhancement of innate immune response to Penicillium marneffei conidia by cooperative interaction of pattern recogntion receptors Sansanee C. Chaiyaroj, N. Ngaosuwannakul, M. Thongpan, Y. Srinoulprasert, P. Chansrichavala Bangkok, Thailand Chairs: Sandra Blois (DEU) Gerard Chaouat (FRA) IL5.19.01 - Galectins in pregnancy: the bitter side of sweet Sandra M. Blois Berlin, Germany W5.19.01 - Fetal loss induced by depletion of innate 33D1+ dendritic cell subset in mice Yasuyuki Negishi, A. Wakabayashi, M. Shimizu, T. Matsuhashi, T. Ichikawa, T. Takeshita, H. Takahashi Tokyo, Japan W6.10 - MUCOSAL VACCINES W5.19.03 - Placental cells promote a tolerant fetal environment by inducing homeostatic macrophages and regulatory T cells Judit Svensson Arvelund, R.B. Mehta, E. Mirrasekhian, S. Freland, G. Berg, M.C. Jenmalm, J. Ernerudh Linköping, Sweden W6.10.02 - Development a novel mucosal vaccine targeted to GP2 on Peyer’s patch M cells Hideaki Shima, T. Watanabe, O. Ohara, H. Ohno Yokohama, Japan W5.19.05 - The atypical chemokine receptor D6 is expressed by trophoblasts and plays roles in placental formation and chemokine scavenging Fiona M. Menzies, P.J. Teoh, C. Waddell, S.M. Nelson, R.J.B. Nibbs Paisley, United Kingdom W6.10.03 - Molecular uniformed rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification induces toxin-specific neutralizing immunity in mice and macaques Yoshikazu Yuki, M. Mejima, S. Kurokawa, T. Hiroiwa, Y. Takahashi, Y. Katakai, M. Kuroda, N. Takeyama, K. Kashima, H. Kiyono Tokyo, Japan W5.19.06 - Genital Chlamydia trachomatis infection induced microRNA profiles may contribute to associated inflammation and reproductive sequelae Bernard P. Arulanandam, R. Gupta, T. Arkatkar, J. Yu, S. Wali, J.P. Chambers, M. Guentzel San Antonio, USA W6.10.05 - Cross-strain protective immunity elicited by a live attenuated nasal spray influenza vaccine 16.45-18.15 AMBER 7+8 16.45-18.15 AMBER 3+4 W5.19.02 - HLA-G expressing DC-10 and CD4+ T cells accumulate in human decidua in the first trimester of pregnancy Giada Amodio, A. Mugione, A. Sanchez, P. Viganò, M. Candiani, E. Somigliana, M. Roncarolo, P. Panina-Bordignon, S. Gregori Milan, Italy W5.19.04 - Demonstration of the deleterious impact of foeto-maternal MHC identity on the success of pregnancy in a macaque model A. Aarnink, E.T. Mee, N. Savy, N.J. Rose, Antoine Blancher Toulouse, France W6.10.01 - Microbe-dependent proliferating IgA-producing plasma cells mediate early-phase robust intestinal IgA responses in mice Jun Kunisawa, E. Hashimoto, I. Ishikawa, Y. Suzuki, R. Sumiya, S. Shikata, H. Kiyono Tokyo, Japan W6.10.04 - Advantage of a new intra-cheek immunization route for therapeutic vaccines of human papillomavirus-associated head and neck cancers Rodney Macedo, G. Lescaille, V. Mateo, C. Baillou, B. Bellier, F.M. Lemoine Paris, France 68 16.45-18.15 AMBER 5+6 Chairs: Mi-Na Kweon (KOR) Charani Ranasinghe (AUS) IL6.10.02 - Novel HIV-1 IL-13R2 adjuvanted vaccines: High avidity mucosal and systemic CD8 T cells with greater protective immunity Charani Ranasinghe, S. Trivedi, D.K. Wijesundara, R.J. Jackson Canberra, Australia W6.10.06 - Safety evaluation of Neuraminidase as a targeting substance of allergen-loaded microparticles for oral food allergy treatment Cornelia Schultz, S.C. Diesner, X. Wang, F. Roth-Walter, T. Eiwegger, Z. Szépfalusi, I. Pali-Schöll, E. Jensen-Jarolim, F. Gabor, E. Untersmayr Vienna, Austria W5.19 - REPRODUCTIVE IMMUNOLOGY W4.06.06 - Are lipid rafts involved in the immune response to Candida albicans? R. Teloni, A. Torosantucci, S. Becattini, F. Sallusto, R. Nisini, Maria C. Gagliardi Rome, Italy IL6.10.01 - Acute epithelial death plays a role in intrinsic defense against enteric bacteria Mi-Na Kweon Seoul, Republic of Korea after prime-boost immunization J. Li, M.T. Arévalo, Y. Chen, Mingtao Zeng El Paso, USA W7.07 - VETERINARY IMMUNOLOGY Chairs: Massimo Amadori (ITA) Wayne Hein (AUS) IL7.07.01 - In vitro evaluation of the anti-inflammatory control actions of interferon-alpha in swine E. Razzuoli, R. Villa, Massimo Amadori Brescia, Italy W7.07.01 - A novel multi-stage subunit vaccine against paratuberculosis induces significant immunity and reduces bacterial burden in tissues Aneesh Thakur, C. Aagaard, U. Riber, K. Skovgaard, P. Andersen, G. Jungersen Copenhagen, Denmark W7.07.03 - Novel peptide-MHC tetramers to characterize the specificity of the CD8+ T cell response against Theileria parva Nicholas Svitek, R. Saya, L. Steinaa, E. Awino, A.M. Hansen, M. Nielsen, S. Buus, V. Nene Nairobi, Kenya W2.12.06 - Molecular profiling of LFA-1 signalling in T cells identifies novel genomic signatures implicated in Th1, Th17 and iTreg polarization N.K. Verma, E. Dempsey, S.P. Barry, A. Davies, Aideen Long, P.G. Fallon, Y. Volkov, D. Kelleher Dublin, Ireland Chairs: Agnes Lehuen (FRA) Tanya J. Webb (USA) IL1.04.01 - Regulatory role of iNKT cells, from viral infection to type 1 diabetes Agnes Lehuen, L. Ghazarian, Y. Simoni, L. Beaudoin, J. Diana Paris, France W7.07.04 - Dendritic cell tracking in pigs Elisa Crisci, L. Fraile, R. Novellas, Y. Espada, R. Cabezon, J. Martínez, D. Benitez, M. Montoya. Bellaterra, Spain W7.07.05 - Development an ELISA method to diagnose infected poultries T. Emami, Rasol Madani, F. Golchinfar Alborz, Islamic Republic of Iran IL1.04.02 - Therapeutic potential of NKT cell adjuvantbased therapies for the treatment of B-cell lymphoma Tonya J. Webb, J. Li, W. Sun, P.B. Subrahmanyam, C. Page, M. Frieman, Q. Chen, A.S. Kimball Baltimore, United States W7.07.06 - A role of myeloid precursor cells (MDSCs), p-STAT 3 and lymphocyte Treg in development of immunosuppression in dogs with skin and mammary cancer Joanna M. Mucha, T. Motyl, K. Majchrzak, M. Król Warsaw, Poland W1.04.01 - Development of MAIT cells in the human fetus Edwin Leeansyah, L. Loh, D.F. Nixon, J.K. Sandberg Stockholm, Sweden W2.12 - SIGNALING IN IMMUNE CELLS W1.04.02 - miRNA regulation of iNKT cell development Maya Fedeli, V. Maselli, M. Riba, G. Rossetti, M. Pagani, S. Abrignani, A. Liston, E. Stupka, P. Dellabona, G. Casorati Milan, Italy Chairs: Christopher E. Rudd (GBR) Tse-Hua Tan (TWN) IL2.12.01 - T-cell signaling via adaptor regulation of the nuclear pore complex (NPC) Christopher E. Rudd Cambridge, United Kingdom W2.12.01 - GRAIL targets CDC37 to maintain CD4 T cell unresponsiveness Chan C. Whiting, D. Gomez-Martin, J.M. Schartner, L. Su, C. Fathman Palo alto, USA 16.45-18.15 BROWN 1 W2.12.05 - IL-7 signalling is motorized in human CD4 T cells Blanche Tamarit, F. Bugault, A. Pillet, V. Lavergne, P. Bochet, J. Thèze, T. Rose Paris, France W1.04 - NKT CELLS W2.12.02 - TRAF6 regulates TCR signalling via interaction with and modification of LAT adapter. J. Xie, J. Liang, L. Diao, A. Altman, Yingqiu Li Guangzhou, China W2.12.03 - TNF reverse signalling induces translocation of CKIP-1 Erno Duda, K. Juhasz, A. Zvara, Z. Balogi, A. Sonnleitner, A. Borsodi Szeged, Hungary W2.12.04 - PI 3-kinase sub-pathways in lymphocyte activation: regulation and functions of phosphatidylinositol (3,4)-bisphosphate Aaron Marshall, N. Jayachandran, H. Li, I. Landego, S. Pauls, S. Hou Winnipeg, Canada 16.45-18.15 BROWN 2 16.45-18.15 AMBER 7+8 W7.07.02 - Bovine viral diarrhea virus actively replicate in bovine monocyte-derived dendritic cells and use them as viral reservoirs Alejandra V. Capozzo, O.L. Franco-Mahecha, W. Czepluch, D.A. Malacari, N. Cardoso, P.R. Grigera Buenos Aires, Argentina 16.45-18.15 BROWN 1 Workshops August 26, 2013 W1.04.03 - The role of NKT cell TCR -chain on antigen specificity Garth Cameron, K.S. Wun, O. Patel, D.G. Pellicci, A.P. Uldrich, A.R. Howell, A.G. Brooks, S.A. Porcelli, J. Rossjohn, D.I. Godfrey Parkville, Australia W1.04.04 - Bacterial CD1d restricted glycolipids induce IL-10 production by human Tregs upon crosstalk with iNKT cells Koen Venken, T. Decruy, S. Aspeslagh, S. Van Calenbergh, B.N. Lambrecht, D. Elewaut Ghent, Belgium W1.04.05 - CD1d-restricted phosphatidic acid-reactive T cells selectively inhibit glycolipid-reactive T cells and protect against inflammatory liver disease Ramesh C. Halder, C. Tran, R.R. Singh; Los Angeles, United States W1.04.06 - Invariant NKT cells in response to dengue virus infection in human. Ponpan Matangkasombut, W. Chan-in, P. Pongchaikul, N. Tangthawornchaikul, S. Vasanawathana, W. Limpitikul, P. Malasit, T. Duangchinda, J. Mongkolsapaya Bangkok, Thailand 69 Chair: Shimon Sakaguchi (JPN) Herman Waldmann (GBR) Harnessing tolerance mechanisms in the clinic Chair: Paul Hertzog (AUS) Tadatsugu Taniguchi (JPN) Regulation of inflammatory responses by HMGB1 and classical cytokines Chair: Sergio Romagnani (ITA) Art Weiss (USA) Regulation of signal transduction by the T cell antigen receptor LL.34 - LUNCHTIME LECTURE Chair: Giuseppe Pantaleo (CHE) Andrew McMichael (GBR) A dance of death: HIV-1 and immunodominant T cells LL.36 - LUNCHTIME LECTURE Chair: Kathryn Wood (GBR) Chris Goodnow (AUS) The IgD enigma: removal of self-reactivity from antibodies on IgD+ IgMlow anergic B cells 12.30 - 13.15 BROWN 3 LL.32 - LUNCHTIME LECTURE 12.30 - 13.15 SPACE 4 Chair: Ronald Germain (USA) Mark M. Davis (USA) Immunology taught by humans 12.30 - 13.15 SPACE 1+2 Chair: Francis Balkwill (AUS) Robert D. Schreiber (USA) Cancer immunoediting: basic mechanisms and therapeutic implications LL.30 - LUNCHTIME LECTURE 18.30 - 19.15 GOLD ROOM PS.10 - PERSPECTIVES IN IMMUNOLOGY PL.09 - PLENARY LECTURE 12.30 - 13.15 AMBER 3+4 12.30 - 13.15 GOLD ROOM 12.30 - 13.15 BROWN 1+2 12.30 - 13.15 SPACE 3 12.30 - 13.15 AMBER 1+2 70 8.50 - 9.20 SPACE 1+2 PS.09 - PERSPECTIVES IN IMMUNOLOGY 9.30 - 10.15 GOLD ROOM 8.50 - 9.20 GOLD ROOM Main Lectures August 27, 2013 LL.31 - LUNCHTIME LECTURE Chair: Vijay Kuchroo (USA) Anne O’Garra (GBR) The immune response in tuberculosis: from mouse models to human disease LL.33 - LUNCHTIME LECTURE Chair: Cornelis Melief (NLD) Francis Balkwill (GBR) Targeting cancer related inflammation LL.35 - LUNCHTIME LECTURE Chair: Juan Rivera (USA) Stephen J. Galli (USA) Roles of mast cells and “allergic responses” in enhancing host resistance to venoms LL.37 - LUNCHTIME LECTURE Chair: Herman Waldmann (GBR) Bali Pulendran (USA) Innate control of adaptive immunity by the integrated stress response PL.10 - PLENARY LECTURE Chair: Andrew McMichael (GBR) Sergio Romagnani (ITA) Human effector CD4+ T cells S25 - INNATE LYMPHOCYTES AND MUCOSAL IMMUNITY S26 - MICROBIOME AND MICROBE ADAPTATION Chairs: Kinston Mills (IRL) Frances Brodsky (USA) Hergen Spits (NLD) S25.01 Characteristics of human innate lymphoid cells in health and disease Andrea Cerutti (ESP) S25.02 Regulation of adaptive antibody responses by the innate immune system Kenya Honda (JPN) S25.03 Regulation of Th17 and Treg cells by the gut microbiota Hilde Cheroutre (USA) S25.04 Unique adaptive Immune defence @ the mucosal front-line of the Intestine Maria Rescigno (ITA) S25.05 Complex interactions among immune and non-immune cells in the gut Chairs: Elizabeth A. Grice (USA) Joel Dorè (FRA) Yasmine Belkaid (USA) S26.01 Commensal control of tissue immunity Sidonia Fagarasan (JPN) S26.02 Symbiotic regulatory loop between T cells, IgA and gut microbiota Mihai Netea (NLD) S26.03 Trained immunity: innate immune imprinting of host-microbe interaction Alessandro Sette (USA) S26.04 The role of human CD4 and CD8 T cells in DENV and MTB immunity and immunopathology Rachel R. Caspi (USA) S26.05 The endogenous microbiome controls development of spontaneous autoimmunity to immunologically privileged neuroretina 10.20 - 12.25 SPACE 1+2 10.20 - 12.25 GOLD ROOM Parallel Symposia August 27, 2013 S28 - IMAGING AND CELL INTERACTIONS Chairs: Francesca Di Rosa (ITA) Stephen P. Schoenberger (USA) Nicholas Restifo (USA) S27.01 Transcriptional and epigenetic control of T cell differentiation Federica Sallusto (CHE) S27.02 Class and specificity of the human T cell response to commensals, pathogens, and allergens Marc K. Jenkins (USA) S27.03 Origins of CD4+ memory T cells David Gray (GBR) S27.04 Tfh heterogeneity, memory and plasma cell survival niches Stephen P. Schoenberger (USA) S27.05 Cellular and molecular regulation of T help for CTL 10.20 - 12.25 BROWN 3 10.20 - 12.25 BROWN 1+2 S27 - IMMUNE MEMORY S30 - TOLERANCE AND TRANSPLANTATION 10.20 - 12.25 SPACE 4 10.20 - 12.25 SPACE 3 S29 - ALLERGY Chairs: Francesca Levi Shaffer (ISR) Walter Canonica (ITA) Cezmi Akdis (CHE) S29.01 Role of tissues in immune regulation in allergic inflammation Juan Rivera (USA) S29.02 The high affinity receptor for IgE: Novel discoveries in signaling and function Gianni Marone (ITA) S29.03 Mast cells and angiogenesis: from allergy to tumor immunology Bart Lambrecht (GBR) S29.04 Epithelial cell - DC interaction in asthma Rudolf Valenta (AUT) S29.05 From allergen genes to allergy vaccines Chairs: Antonella Viola (ITA) Sarah Russell (AUS) Mike L. Dustin (USA) S28.01 Getting to the center of the immunological synapse Reinhold Förster (DEU) S28.02 Killing me softly: how cytotoxic T cells destroy virus-infected target cells in vivo Ronen Alon (ISR) S28.03 What determines the directionality of leukocytes transendothelial migration? Luca Guidotti (ITA) S28.04 Visualizing and regulating the traffic of pathogenic CD8+ T cells within the liver Ronald Germain (ISA) S28.05 Using advanced dynamic and multiplex static imaging to probe innate and adaptive immunity in vivo Chairs: Claudio Ponticelli (ITA) Andrea Biondi (ITA) Kathryn Wood (GBR) S30.01 Immunoregulation in transplantation Megan Sykes (USA) S30.02 Mechanisms of tolerance in patients receiving combined kidney and bone marrow transplantation Narinder Mehra (IND) S30.03 Clinical and immunological relevance of antibodies in transplantation Harvey Cantor (USA) S30.04 Regulatory T-cells: therapeutic targets of opportunity Luigi Naldini (ITA) S30.05 Genetic engineering of hematopoiesis for treatment of human diseases 71 Late Breaking Sessions August 27, 2013 LB1 - LATE BREAKING SESSION - BASIC RESEARCH Chair: Stefan H.E. Kaufmann (DEU) 13.30 - 14.30 GOLD ROOM LB1.01 - Specification of innate type-2 lymphocytes by the transcriptional determinant Gfi1 Chauncey J. Spooner, J. Lesch, D. Yan, A. Abbas, M. Xu, J. DeVoss, H. Singh San Francisco, United States LB1.02 - Identification of a common monocyte progenitor Jan Hettinger, D.M. Richards, J. Hansson, M.M. Barra, A.C. Joschko, J. Krijgsveld, M. Feuerer, Heidelberg, Germany LB1.03 - Distinct TLR4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation Jaclyn W. McAlees, G.S. Whitehead, I. Harley, M. Cappelletti, C.L. Rewerts, A. Holdcroft, S. Divanovic, C.L. Karp, D.N. Cook Cincinnati, United States LB1.04 - Seeing is believing: visualization of the thymic T-cell development in a quantitative and non-invasive manner Baubak Bajoghli, D. Inoue, M. Rauzi, P. Kuri, N. Aghaallaei, Y. Taniguchi, A. Toyoda, J. Wittbrodt, M. Leptin Heidelberg, Germany LB1.05 - A global approach to study viral antigen presentation using immunoproteomics N.P. Croft, D.C. Tscharke, Anthony W. Purcell Clayton, Australia LB1.06 - Molecular characterization of a novel antigen specific, immunoglobulin expressing cell in immunized animals with phenotypic characteristics of both granulocytes and lymphocytes Jody D. Berry, E. Chronopoulou, A. Uribe-Benninghoff, J. Fisher, X. Ji, J. Elia, P. Waterman, D. Stupack La Jolla, United States LB2 - LATE BREAKING SESSION - TRANSLATIONAL RESEARCH Chair: Jorge Kalil (BRA) 13.30 - 14.30 SPACE 1+2 LB2.01 - Identification of specific markers for type 2 (pro-allergic) human dendritic cells: interest as follow-up markers for immunotherapy Laurent Mascarell, C. Gueguen, H. Moussu, P. Moingeon, V. Baron-Bodo Antony, France LB2.02 - Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective IFN- Noriko M. Tsuji, T. Kawashima, H. Yan, Z. Guo, J. Carreras, R. Uchiyama, R. Fukui, T. Kaisho, S. Akira, K. Miyake, H. Tsutsui, T. Saito Tsukuba, Japan LB2.03 - Human antigen-specific CD4+CD25+CD134+CD39+ T cells are enriched for regulatory T cells and comprise a substantial proportion of CD4+ T cell antigen recall responses Laura Cook, N. Seddiki, C. Munier, J. Zaunders, A.D. Kelleher Sydney, Australia LB2.04 - Human memory Helios- FOXP3+ Treg encompass induced Treg that express Aiolos and respond to IL-1 by downregulating their suppressor functions Maha Ayyoub, C. Raffin, P. Pignon, C. Celse, D. Valmori Nantes-Saint Herblain, France LB2.05 - B lymphocytes undergo TLR2-dependent apoptosis upon Shigella infection mediated by the virulence factor IpaD Katharina Nothelfer, E.T. Arena, L. Pinaud, M. Neunlist, I. Belotserkovsky, C. Parsot, R. Raqib, B. Mozeleski, P.J. Sansonetti, A. Phalipon Paris, France LB2.06 - CD14+CD16-, CD14+CD16+ and CD14dimCD16++ monocyte subsets are changed in obesity Mariana Renovato-Martins, E. Devevre, K. Clément, A. Basdevant, C. Sautes-Fridman, I. Cremer, C. Poitou Rio de Janeiro, Brazil 72 Workshops August 27, 2013 W6.11 - VACCINATION AND IMMUNOTHERAPY FOR INFECTIOUS DISEASES W6.11.09 - Chimeric flagellin as the selfadjuvanting antigen for antibody response against Helicobacter pylori J. Mori, Tanja Vranac, B. Smrekar, M. Cernilec, V. Curin Serbec, S. Horvat, A. Ihan, M. Ben ina, R. Jerala Ljubljana, Slovenia Chairs: Nicholas King (AUS) Maria Bellio (BRA) IL6.11.01 - Novel Immune-modifying Nanoparticles for the Treatment of Inflammatory monocyte-mediated Disease D.R. Getts, R.L. Terry, M.T. Getts, C. van Vreden, T.M. Ashhurst, S.J. Cordwell, E.B. Thorp, S. Bao, S.D. Miller, Nicholas J.C. King Sydney, Australia W6.11.03 - IL-4 and IL-13 regulates CD8 co-receptor expression to dampen the quality of anti-viral CD8+ T cell immunity following HIV-1 prime-boost vaccination D.K. Wijesundara, R.J. Jackson, D.C. Tscharke, Charani Ranasinghe Canberra, Australia W6.11.05 - Fusion of HCV non-structural antigen to MHC-II associated invariant chain enhances T cell responses induced by vectored vaccines in non-human primates Antonella Folgori, S. Capone, M. Naddeo, A. Abbate, M. Del Sorbo, M. Esposito, V. Ammendola, S. Colloca, A. Nicosia, R. Cortese Rome, Italy W6.11.07 - Identification of novel Streptococcus pneumoniae candidate vaccine antigen Yaffa Mizrachi Nebenzahl, M. Pornoi, D. Kafka, M. Shagan, A. Adawi, A. Ohayon, S. Dotan, M. Tal, R. Ellis, R. Dagan Beer Sheva, Israel W6.11.08 - Diminished levels of pneumococcal polysaccharide (PPS) responding ‘B1 like’ cells and it’s corelation with poor anti PPS response post PPV-23 in long term HAART cohorts Anita S. Iyer, D.J. Leggat, N.M. Khaskhely, M. Westerink Toledo, USA W6.11.12 - Langerin negative dendritic cells promote potent CD8+ T-cell priming after skin delivery of a recombinant adenovirus-based vaccine using microneedle arrays V. Bachy, C. Hervouet, P. Becker, L. Chorro, L.M. Carlin, S. Herath, S. Oh, S.Y. Kwon, F. Geissmann, Linda S. Klavinskis London, United Kingdom W6.11.14 - microRNA-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated myocyte apoptosis Wei Xu, J. He, Y. Yue, S. Xiong Suzhou, China W6.11.04 - Type 2 diabetes patients, both young and elderly, have optimal B cell responses to the seasonal influenza vaccine Daniela Frasca, A. Diaz, M. Romero, A. Landin, B.B. Blomberg Miami, USA W6.11.06 - Antigenization of bovine immunoglobulin variable regions for development of novel vaccines Yfke Pasman, A.K. Kaushik Guelph, Canada W6.11.11 - Necrotic cell vaccine against hepatitis C Branka Grubor-Bauk, P. Latour, W. Yu, B. Loveland, E. Gowans Adelaide, Australia W6.11.13 - Targeting of antigen via XCR1, the lineage marker for cross-presenting dendritic cells, elicits potent CD8 cytotoxicity in vivo Evelyn Hartung, M. Becker, A. Bachem, N. Reeg, Y. Yang, A. Jäkel, H. Weber, V. Henn, H. Mages, R.A. Kroczek Berlin, Germany W1.03 - NK CELLS AND NK RECEPTORS Chairs: Gunnur Deniz (TUR) Cristina Bottino (ITA) IL1.03.01 - Cross-talk bethween human natural killer cells and macrophages F. Bellora, R. Castriconi, A. Doni, A. Mantovani, A. Pessino, A. Moretta, Cristina Bottino Genova, Italy 15.10-18.15 BROWN 3 15.10-18.15 GOLD ROOM W6.11.02 - Enhanced and accelerated memory CD8 T cell formation by immunization with MVA-CD40L Henning Lauterbach, J. Pätzold, R. Kassub, B. Bathke, K. Brinkmann, P. Chaplin, M. Suter, H. Hochrein Martinsried, Germany 15.10-18.15 GOLD ROOM W6.11.01 - HIV CD4 based vaccine pre-immunization increases CD8 T cell responses and confers protection against challenge with a recombinant vaccinia virus encoding HIV Gag-Pol proteins Susan P. Ribeiro, A.D. Faria, R.R. Almeida, V.C. Santana, D.S. Rosa, E.G. Kallas, J. Kalil, E. Cunha-Neto São Paulo, Brazil W6.11.10 - Improved assay for quantification of immunoreactive hemagglutinin for potency determination and stability analysis in trivalent influenza vaccines using isotope dilution mass spectrometry Carrie L. Pierce, T.L. Williams, W. Wang, J.L. Bundy, J.R. Barr Atlanta, USA IL1.03.02 - Functionally distinct subsets of human NK cells Gunnur Deniz Istanbul, Turkey W1.03.01 - NK cell subsets isolated from human thymus differ from peripheral blood NK cells in their phenotype and their cytotoxic and cytokine secreting capabilities S. Krieg, W. Kroeger, G. Heidkamp, K. Winterling, A. Purbojo, R. Cesnjevar, A. Mackensen, D. Dudziak, Evelyn Ullrich Frankfurt, Germany W1.03.02 - Neuraminidase-mediated NKp46-dependent immune evasion mechanism of influenza viruses Yotam Bar-On, O. Mandelboim Jerusalem, Israel 73 W1.03.03 - NK cells from malignant pleural effusions are not anergic but produce cytokines and display strong anti-tumor activity on short-term IL-2 activation Paola Vacca, S. Martini, L. Moretta, M.C. Mingari Genoa, Italy W1.03.04 - Unique CD56bright CD16+ NK cells infiltrate regional metastatic lymph nodes from stage III melanoma patients Meriem Messaoudene, G. Fregni, E. FourmentrauxNeves, J. Chanal, M. Avril, A. Caignard Paris, France 15.10-18.15 BROWN 3 Workshops August 27, 2013 W1.03.05 - NK cells targeting of human and mouse Cancer Initiating Cells Rossana Tallerico, S. Di Franco, C. Maccalli, L. Conti, S. Lanzardo, C. Garofalo, R. Sottile, M. Todaro, G. Stassi, F. Cavallo Catanzaro, Italy Chairs: Carlo Agostini (ITA) Angus W. Thomson (USA) W1.03.12 - Defining the lethal hit: Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack Jamie A. Lopez, O. Susanto, M.R. Jenkins, N. Lukoyanova, V.R. Sutton, R.H.P. Law, J.C. Whisstock, H.R. Saibil, J.A. Trapani, I. Voskoboinik Melbourne, Australia 15.10-16.40 SPACE 1 15.10-18.15 BROWN 3 W6.14.02 - Induction of immune tolerance by antigen loaded erythrocytes: Innovative therapy for therapeutic protein allergy Magali Cremel, N. Guerin, W. Berlier, F. Horand, Y. Godfrin Lyon, France W1.03.08 - Human M1 macrophages activate resting NK cell antitumoral activities through IL-15/IL-15RA transpresentation Irene Mattiola, M. Pesant, P. Tentorio, D. Mavilio, M. Locati Milan, Italy W1.03.11 - Innate immunity driving tumor angiogenesis: the role of NK cells in non-small cell lung cancer Antonino Bruno, F. Chiara, A. Pagani, I. Andrea, M. Spagnoletti, C. Capella, G. Ferlazzo, L. Mortara, D. Noonan, A. Albini Milan, Italy 74 W6.14.01 - Immunological outcomes during 1 year of treatment with the anti-IL-12/23 p40 monoclonal antibody ustekinumab for psoriasis Aurore Rozieres, C. Lambert, C. Paul, K. Reich, M. Brunori, P. Bergmans, E. Martens, E. Rizova, J. Nicolas Lyon, France W1.03.07 - Regulation of the activating NKp30 ligand B7-H6 in tumor cells Nathalie Fiegler, S. Textor, A. Arnold, A. Rölle, I. Oehme, K. Breuhahn, G. Moldenhauer, M. Witzens-Harig, A. Cerwenka Heidelberg, Germany W1.03.10 - The viral KSHV chemokine vMIP-II inhibits the migration of naive and activated human NK cells by antagonizing two distinct chemokine receptors Rachel Yamin, N. Stanietsky-Kaynan, A. Glasner, Y. Bar-On, S. Elias, C. Gur, O. Mandelboim Jerusalem, Israel W1.03.14 - Analyzing and modeling the dynamics of differentiating and adoptively transferred NK cells in patients undergoing hematopoietic stem cell transplantation M. Killig, B. Friedrichs, J. Meisig, M. Luetke-Eversloh, L. Uharek, Chiara Romagnani, C. Ranasinghe Berlin, Germany W6.14 - IMMUNOSUPPRESSIVE AND TOLEROGENIC TREATMENTS W1.03.06 - Novel mouse models reveal how expression of NKG2D and its ligands on various cell subsets affects immune responses Maelig G. Morvan, M. Champsaur, N.L. Johnson, V. Sexl, L.L. Lanier San Francisco, USA W1.03.09 - Natural killer cell distribution and traffikking in normal and neoplastic human tissues Paolo Carrega, I. Bonaccorsi, E. Di Carlo, M. Mingari, L. Moretta, G. Ferlazzo Genoa, Italy W1.03.13 - Gap Junction intercellular communication induces NK cell activation and modulates cytotoxic capacity Israel J. Guerrero, A. Tittarelli, A. Mendoza-Naranjo, M. Farías, M. López, B. Chambers, F. Salazar-Onfray Santiago, Chile W6.14.03 - Therapeutic role of the novel negative checkpoint regulator VISTA in murine autoimmune disease models Sabrina Ceeraz, I. Le Mercier, P. Sergent, A. Schned, C. Burns, R. Noelle Lebanon, USA W6.14.04 - IL-7 receptor blockade by monoclonal antibody to IL-7R induces islet allograft tolerance and long-term skin allograft survival through inhibition of T cell reconstitution Hoa L. Mai, F. Boeffard, J. Lepourry, R. Danger, B. Martinet, B. Vanhove, S. Brouard, J.P. Soulillou Nantes, France W6.14.05 - Control of autoimmunity by Treg-inducing liver sinusoidal endothelial cells Antonella Carambia, B. Freund, D. Schwinge, O.T. Bruns, S.C. Salmen, H. Ittrich, R. Reimer, M. Heine, J. Heeren, J. Herkel Hamburg, Germany W6.14.06 - Induction of immunosuppression by mesenchymal stem cells Yufang Shi Shanghai, China Workshops August 27, 2013 W5.07 - ANIMAL MODELS OF AUTOIMMUNITY W6.12.04 - Soluble FGL2 induces tubular epithelial cells apoptosis in renal allograft rejection Zitong Zhao, C. Yang, L. Wang, L. Li, T. Zhao, L. Hu, R. Rong, M. Xu, T. Zhu Shanghai, China IL5.07.01 - Experimental model of autoimmune prostatitis Clelia Maria Riera, M. Maccioni, R. Motrich, V. Rivero Cordoba, Argentina W5.07.02 - Small intestine inflammation in roquinmutant and roquin-deficient mice J.S. Schaefer, D. Montufar-Solis, N. Vigneswaran, John R. Klein Houston, USA W2.07 - PERIPHERAL TOLERANCE AND LYMPHOCYTE ANERGY W5.07.03 - Tolerance induction by hair-specific keratins in murine alopecia areata Ulrike Erb, P. Freyschmidt-Paul, M. Zoeller Heidelberg, Germany Chairs: Bonnie Blomberg (USA) Sachiko Miyake (JPN) W5.07.04 - Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of sialoadenitis in wild-type mice Davide Lucchesi, M. Bombardieri, S. Nayar, G. Proctor, F. Barone, C.D. Buckley, C. Pitzalis London, United Kingdom W2.07.01 - Induction of antigen-specific tolerance upon infusion of Fc-fusion proteins via the maternofetal interface Nimesh Gupta, Y. Meslier, S. André, S. Culina, S. Delignat, B.L. Salomon, R. Mallone, S. Kaveri, S. Lacroix-Desmazes Paris, France W5.07.05 - Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcRIIB-deficient C57BL/6 mice Sachiko Hirose, S. Kawano, Q. Lin, H. Amano, T. Kaneko, K. Nishikawa, H. Tsurui, N. Nishimura, T. Shirai Tokyo, Japan W2.07.02 - Ly9 (CD229) cell surface receptor ameliorates autoimmune response Xavier Romero, J. de Salort, P. Engel Barcelona, Spain W5.07.06 - SPARC deficiency promotes lupus like autoimmunity by defective clearance of dead PMN Caterina Vitali, S. Sangaletti, C. Tripodo, C. Bassani, M. Parenza, M.P. Colombo Milan, Italy W6.12 - ORGAN TRANSPLANTATION Chairs: Birgit Sawitzki (DEU) Chiara Romagnani (ITA) 15.10-16.40 SPACE 3 W6.12.05 - Association of splenic CD11c+ B-cell population with long-term graft tolerance in mouse cardiac transplantation model T. Wang, Tongmin Wang, J. Guo, J. Tao, J. Yang, J. Zhu, W. Yang Kunming, China W6.12.06 - Tolerance induction to immunogenic grafts via antigen-specific Tregs without the need for chronic immunosuppression Matthias Hardtke-Wolenski, N. Seltrecht, N. Mpofu, R. Taubert, F. Noyan, M.P. Manns, E. Jaeckel Hannover, Germany W6.12.01 - Monitoring indirect allorecognition in renal transplant recipients Eytan Breman, P.P. van Miert, M.H. Heemskerk, D. Roelen, F.H. Claas, C. van Kooten Leiden, Netherlands W6.12.02 - In vitro and in vivo characterization of IL9 producing alloreactive T cells Katarina Stanko, J. Schumann, U. Schliesser, C. Appelt, K. Vogt, B. Sawitzki Berlin, Germany W6.12.03 - Experimental chronic lung allograft damage S. Atanasova, A. Evers, D. Jonigk, K. Petri, A. Zakrzewicz, M. Obert, J. Schmitz, M. Hirschburger, W. Padberg, Veronika Grau Giessen, Germany 15.10-16.40 SPACE 4 15.10-16.40 SPACE 2 W5.07.01 - Effector memory exhausted tissue resident CD8 T cells accumulate during chronic experimental autoimmune uveitis Joanne Boldison, D. Copland, A.D. Dick, L.B. Nicholson Bristol, United Kingdom 15.10-16.40 SPACE 3 Chairs: Clelia Maria Riera (ARG) Costantino Pitzalis (GBR) W2.07.03 - An agonistic anti-BTLA mAb (3C10) induced generation of IL-10 dependent regulatory CD4+ T cells and prolongation of murine cardiac allograft Masateru Uchiyama, X. Jin, Q. Zhang, L. Yu, H. Bashuda, H. Matsuda, H. Yagita, M. Niimi Tokyo, Japan W2.07.04 - Upregulation of inhibitory molecules in T cells is associated with altered functions of dendritic cells by HIV-1 and activation of the P38MAPK/STAT3 pathway Esaki M. Shankar, K.F. Che, M. Larsson Kuala Lumpur, Malaysia W2.07.05 - IL-15 reverses age-related CD8+ T cell inactivation with increasing IFN production and improves survival in aged septic mice Shigeaki Inoue, K. Suzuki-Utsunomiya, Y. Komori, S. Inokuchi, K. Hozumi, T. Sato Isehara, Japan W2.07.06 - Upregulation of glucocorticoid-induced leucine zipper by hepatocyte growth factor promotes tolerogenic dendritic cells and inhibits experimental autoimmune encephalomyelitis Mahdia Benkhoucha, N. Molnarfi, M. Santiago-Raber, G. Schneiter, P. Lalive Geneva, Switzerland 75 Workshops August 27, 2013 W3.15 - B AND T CELL MEMORY IL3.15.01 - Regulation of human CD8+ T cell effector functions Rene A. Van Lier, K. Hertoghs, F. Vieira Braga, M. Brouwer, L. Aarden, I. Derks, E. Eldering, M. Nolte, I. ten Berge, K. van Gisbergen Amsterdam, Netherlands W3.15.01 - Disparate individual fates compose robust CD8+ T cell immunity Veit R. Buchholz, M. Flossdorf, I. Hensel, L. Kretschmer, B. Weissbrich, P. Gräf, M. Schiemann, T. Höfer, D.H. Busch Munich, Germany 15.10-16.40 AMBER 1+2 W6.04.03 - Survivin as a target for therapeutic RNA interference in experimental arthritis Sofia E.M. Andersson, M.N.D. Svensson, M.C. Erlandsson, I. Jonsson, K.M.E. Andersson, M.I. Bokarewa Gothenburg, Sweden Rene Van Lier (NLD) Attilio Bondanza (ITA) 15.10-16.40 AMBER 3+4 Chair: W3.15.02 - Late IL-2 signals limit effector CD4 T cell contraction and serve as a checkpoint for transition to memory Kai K. McKinstry, T.M. Strutt, A.M. Cooper, S.L. Swain Worcester, USA W5.05 - ENVIRONMENTAL FACTORS IN AUTOIMMUNITY AND ALLERGY Chairs: Yehuda Schoenfeld (ISR) Eva Sverremark-Ekstrom (SWE) W3.15.04 - The transcription factor Zeb2 plays a role in promoting terminal differentiation of CD8+ T-cells through repression of the miR-200 family Claudia X. Dominguez, S.M. Kaech New Haven, USA IL5.05.01 - ‘ASIA’ - Autoimmune (Auto-inflammatory) syndromes induced by adjuvants Yehuda Shoenfeld Tel Hashomer, Israel W3.15.05 - IL-12-mediated STAT4 signaling and T-cell receptor (TCR) signal strength cooperate in induction of CD40L in human and mouse CD8+ T cells Regina Stark, A. Haese, S. Durlanik, K. Hoffmann, N. Matzmohr, D. Zehn, M. Frentsch, A. Thiel Lausanne, Switzerland 15.10-16.40 AMBER 3+4 Chairs: Marco Matucci Cerinic (ITA) Johannes Roth (DEU) W6.04.01 - Human cathelicidin-derived peptide IG-19 regulates cytokine IL-32-induced inflammation in human blood mononuclear cells, and provides protection in a murine model of arthritis Ka-Yee (Grace) Choi, L.N.Y. Chow, M. Bossert, T. Klonisch, J. Uzonna, N. Mookherjee Winnipeg, Canada W6.04.02 - The pro-inflammatory activities of IL-6 are mediated by the soluble Interleukin-6 receptor via trans-signalling Stefan Rose-John Kiel, Germany 76 IL5.05.02 - Early-life microbial exposures and allergy development - exploring the role of herpesviruses Eva Sverremark-Ekstrom Stockholm, Sweden 15.10-16.40 AMBER 5+6 W6.04 - TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER INFLAMMATORY JOINT DISEASES W6.04.05 - Blockade of CCR6 and CCL20 interaction ameliorates arthritis and contact hypersensitivity reaction in mice Kenzo Muramoto, A. Bender, T. Horizoe, M. Nishimura, T. Imai Chuo-ku, Japan W6.04.06 - The effect of CXCL10 blockade in C protein-induced myositis Yeong-Wook Song, J. Kim, J. Choi, S. Chang, K. Shin, S. Park, E. Lee, E. Lee, H. Kawachi, H. Kohsaka Seoul, Republic of Korea W3.15.03 - Id2-mediated inhibition of E2A represses memory CD8 T cell differentiation Frédérick Masson, M. Minnich, M. Olshansky, A. Kallies, T.P. Speed, M. Busslinger, S.L. Nutt, G.T. Belz Parkville, Australia W3.15.06 - Survival of CD8 memory T cell precursors depends on NKG2D mediated PI3K signalling and Mcl-1 induction Felix M. Wensveen, M. Lenarti , V. Jelen i , N.A.W. Lemmermann, A. ten Brinke, S. Jonji , M. Colonna, B. Poli Rijeka, Croatia W6.04.04 - Critical role of all-trans retinoic acid in stabilizing human nTregs under inflammatory conditions Songguo Zheng, Z. Liu Shanghai, China W5.05.01 - Ectopic lymphoid structures support Epstein-Barr virus persistence and autoreactive plasma cell infection in Sjogren’s syndrome salivary glands C. Croia, B. Serafini, N. Sutcliffe, A. Tappuni, F. Aloisi, C. Pitzalis, Michele Bombardieri London, United Kingdom W5.05.02 - A single non-synonymous polymorphism of TLR2 is sufficient to recapitulate the variability of experimental multiple sclerosis Giuseppe Migliara, G. Di Sante, A. Piermattei, C. Nicolò, M. Valentini, A. Procoli, M. Geloso, M. Corbi, A. Sgambato, F. Ria Rome, Italy W5.05.03 - High salt diet exacerbates autoimmune disease by induction of pathogenic Th17 cells Markus Kleinewietfeld, A. Manzel, R.A. Linker, D.N. Muller, D.A. Hafler New Haven, USA W5.05.04 - Impact of infectious agents on trafficking of effector T cells is mediated by a polymorphic site of TLR2 and CD44 isoforms expression Gabriele Di Sante, E. De Paolis, A. Piermattei, M. Valentini, G. Migliara, C. Nicolò, G. Constantin, E. Giorda, G. Delogu, F. Ria Rome, Italy 15.10-16.40 AMBER 5+6 Workshops August 27, 2013 W7.01 - IMAGING OF THE IMMUNE SYSTEM W5.05.05 - Aryl hydrocarbon receptor modulates psoriatic skin inflammation Paola Di Meglio, J.H. Duarte, H. Ahlfors, N.D.L. Owens, F. Villanova, K. Hirota, M. Gilchrist, F.O. Nestle, U. Mrowietz, B. Stockinger London, United Kingdom Chairs: Matteo Iannacone (ITA) Jens Stein (CHE) IL7.01.01 - In vivo imaging of intrahepatic effector CD8 T cell dynamics Matteo Iannacone Milan, Italy W5.05.06 - IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation S. Kamijo, Toshiro Takai, M. Hara, A. Matsuda, H. Saito, S. Nakae, K. Sudo, S. Ichikawa, H. Ogawa, K. Okumura Tokyo, Japan IL7.01.02 - Intracellular control of central versus effector memory T cell migration and activation Jens V. Stein Bern, Switzerland W7.01.01 - Lateral distribution of the T cell receptor and membrane lipid detected by high resolution secondary ion mass spectrometry Feng Wang, M.M. Lozano, B.F. Lillemeier, S.G. Boxer, M.M. Davis Stanford, USA W4.12 - MICROBIOME, GUT FLORA AND INFLAMMATION IL4.12.01 - Adenoma induced reshaping of the gut microbiome controls host dependent progression of colon cancer V.R. Jala, P. Maturu, E. Krishnan, S. Mathis, S.R. Bodduluri, M. Wang, R. Knight, Haribabu Bodduluri Louisville, United States IL4.12.02 - Control of mucosal immune responses by vitamin A Reina Mebius, G. Goverse, B. Olivier, R. Molenaar, M. Knippenberg, M. Greuter, T. Konijn, T. O’Toole, G. Bouma Amsterdam, Nederland 15.10-16.40 BROWN 1 Chairs: Haribabu Bodduluri (USA) Reina Mebius (NLD) W4.12.02 - Dietary fibers downregulate low-grade inflammation systemically in mice Stine B. Metzdorff, C.H.F. Hansen, A.G. Christensen, A. Bergström, T.R. Licht, A.K. Hansen, H. Frøkiær Frederiksberg, Denmark W7.01.05 - Single cell analysis of molecular networks involved in T cell activation and signalling. Ruth Brignall, J. Bagnall, L. Schmidt, D. Spiller, D.A. Jackson, M. Travis, M.R.H. White, P. Paszek Manchester, United Kingdom W4.12.03 - Critical IL-23 based cross regulation of colonic DCs by macrophages protects mice from Citrobacter challenge Tegest Aychek, A. Mildner, S. Yona, K. Kim, S. Jung Rehovot, Israel W7.01.06 - Dynamic expression of co-stimulatory and co-inhibitory receptors regulates termination of T cell-DC interaction during CD8 T cell activation Mario Perro, J. Godec, S. Loughhead, I. Mazo, S. Henrickson, W.N. Haining, A.H. Sharpe, U.H. von Andrian Boston, USA W4.12.04 - Fungal communities throughout the intestine and their role in intestinal inflammation Iliyan D. Iliev, V. Funari, D. Underhill Los Angeles, USA W4.12.05 - Diet and gut microbiota play a key role in autoimmune diabetes E. Marino, Eliana Marino Melbourne, Australia W4.12.06 - Probiotics as immune-regulators in the rat experimental autoimmune encephalomyelitis and myasthenia gravis models Chiara Cordiglieri, R. Marolda, M. Elli, R. Mantegazza, F. Baggi Milan, Italy W7.01.03 - Comprehensive confocal imaging and 3D computer analysis of blood and lymphatic vascular channels across entire lymph nodes Inken Kelch, G. Bogle, A. Phillips, I.J. LeGrice, G.B. Sands, D.A. Gerneke, C.J. Mansell, P.R. Dunbar Auckland, New Zealand W7.01.04 - Skin patrol by tissue-resident CD8+ T cells Silvia Ariotti, J.B. Beltman, G. Chodaczek, M. Hoekstra, A.E. van Beek, R. Gomez-Eerland, L. Ritsma, J. van Rheenen, A. Maree, T. Zal Amsterdam, Netherlands W1.12 - LECTINS AND GLYCOIMMUNOLOGY Chairs: Fu-Tong Liu (USA) Chitra Mandal (IND) 15.10-16.40 BROWN 2 15.10-16.40 AMBER 7+8 W4.12.01 - The molecular characterization of Helicobacter activated regulatory B cells and their role in gastric immunopathology Ayca Sayi Yazgan, M. Karayılan, N. Mansur, A. Müller Istanbul, Turkey W7.01.02 - Role of colonic lymphoid patch dendritic cells in patrolling the colonic lumen, transporting antigen, and imprinting homing of T cells to the colon Jay A. Berzofsky, A. Dzutsev, A. Hogg, L. Koo, H. Yu, R. Goldszmid, J. Kabat, Y. Sui, O. Schwartz, G. Trinchieri Bethesda, USA IL1.12.01 - Galectins in Inflammation and Immunity Fu-Tong Liu Taipei, Taiwan IL1.12.02 - Molecular interplay between sialic acids and siglecs in subversion of host innate immune response by Pseudomonas aeruginosa Chitra Mandal, B. Khatua Kolkata, India 77 W1.12.01 - C-type lectin MCL is a receptor for mycobacterial cord factor TDM and is critical for Mincle induction Yasunobu Miyake, K. Toyonaga, D. Mori, S. Kakuta, Y. Hoshino, Y. Iwakura, S. Yamasaki Fukuoka, Japan W6.15.03 - Sub-visible particles in protein therapeutics - are they responsible for the induction of unwanted immune responses? Christian Lubich, M. Malisauskas, T. Prenninger, C. Lenk, E. Hopfner, F. Scheiflinger, B.M. Reipert Vienna, Austria W1.12.02 - Targeting C-type lectin receptors on dendritic cells for neonatal adjuvant setting Sebastien Lemoine, B. Jaron, E. Deriaud, C. Leclerc, R. Lo-Man Paris, France W6.15.04 - Assessing immune toxicity of engineered nanoparticles: modulation of inflammation in a novel in vitro model based on human primary monocytes Yang Li, P. Italiani, E. Caslas, V.F. Puntes, D. Boraschi Pisa, Italy W1.12.03 - A novel role of beta-glucan in improving anti-tumor immunity by regulating monocytic myeloid-derived suppressor cells Jie Tian, K. Ma, H. Guo, J. Chen, H. Xu, S. Wang Zhenjiang, China 16.40-18.15 SPACE 1 15.10-16.40 BROWN 2 Workshops August 27, 2013 W1.12.04 - Soluble CD52 is a negative regulator in the innate immune system Maryam Rashidi, Y. Zhang, E. Bandala-Sanchez, J.M. Wentworth, J. Vince, L.C. Harrison Melbourne, Australia W6.15.06 - Molecular mechanisms associated to a new combined therapy for multiple sclerosis Giselle Pentón-Rol, N. Lagumersindez-Denis, M. Cervantes-Llanos M, V. Falcón-Cama, L. Muzio, M. Nazabal-Gálvez, T. Veliz, R. Furlan, A. Mantovani, E. Pentón-Arias Havana, Cuba W1.12.05 - Galectin-3 promotes cell-to-cell transmission of HIV-1 S.F. Wang, D.K. Hsu, Y.M.A. Chen, Huan Y. Chen, F.T. Liu Taipei, Taiwan W6.05 - PREVENTION AND INTERVENTION IN ALLERGY Chairs: Sergio Bonini (ITA) Revaz Sepiashvili (RUS) W1.12.06 - Galectin 3 affects DCs:NKT cell interaction in the development of GalCer-induced hepatitis Vladislav B. Volarevic, M. Milovanovic, B. Simovic Markovic, S. Bojic, M. Stojanovic, N. Arsenijevic, G. Besra, M.L. Lukic Kragujevac, Serbia IL6.05.01 - Allergy in the CIS-countries Revaz Sepiashvili, T. Slavyanskaya; Moscow, Russian Federation W6.05.01 - Application of HLA-II peptide tetramers vs. allergen-induced proliferation for identification of allergen-specific CD4 T cells in the model of mugwort pollen allergy Beatrice Jahn-Schmid, D. Van Hemelen, V. Mahler, I. Fae, G. Fischer, B. Bohle Vienna, Austria W6.15 - IMMUNOPHARMACOLOGY 16.40-18.15 SPACE 1 IL6.15.02 - Molecular mechanisms associated to a new combined therapy for multiple sclerosis Giselle Penton Rol, N. Lagumersindez-Denis, M. Cervantes-Llanos, V. Falcón-Cama, L. Muzio, M. Nazabal-Gálvez, T. Veliz, R. Furlan, A. Mantovani, E. Pentón-Arias Havana, Cuba W6.15.01 - L-GILZ forms a complex vith p53 and mdm2 and suppresses tumor growth through p53 activation Emira M. Ayroldi, M. Petrillo, A. Bastianelli, S. Ronchetti, C. Marchetti, G. Nocentini, L. Cannarile, C. Riccardi Perugia, Italy W6.15.02 - Bringing together the potential of immune cells and the power of new drugs to target cancers by nanoparticles Cinzia Garofalo, L. Izzo, R. Strong, V. Groh, R. Sottile, R. Tallerico, D. Pappalardo, E. Carbone Catanzaro, Italy 78 16.40-18.15 SPACE 2 Chairs: Giselle Penton Rol (CUB) Diana Boraschi (ITA) IL6.15.01 - Modelling human inflammation in vitro with human blood monocytes Diana Boraschi, P. Giungato, Y. Li, P. Italiani Pisa, Italy W6.15.05 - Protein kinase C regulates inducible nitric oxide synthase expression through IRF1 Tiina Leppänen, R. Korhonen, M. Laavola, R. Nieminen, R.K. Tuominen, E. Moilanen Tampere, Finland W6.05.02 - Antibodies specific for the junction of CH4 domain and CmX in membrane-bound IgE are potentially useful for down-regulating mIgE-B lymphocytes Chien-Jen Lin, N. Chen, J. Chen, Y. Shiung, C. Lu, A.F. Hung, P.C. Wu, T. Chang Taipei, Taiwan W6.05.03 - Mast cell-derived prostaglandin D2 suppresses intestinal mastocytosis in food allergy Tatsuro Nakamura, S. Matsumoto, K. Aritake, M. Hori, H. Ozaki, Y. Urade, T. Murata Tokyo, Japan W6.05.04 - Robust long-term tolerance in IgE-mediated allergy through transfer of allergen-expressing bone marrow cells Ulrike Baranyi, B. Linhart, A.M. Farkas, K. Hock, T. Rülicke, R. Valenta, T. Wekerle. Vienna, Austria W6.05.05 - Sublingual immunotherapy induces regulatory T cells in cervical lymph node of murine allergic rhinitis model Hideyuki Kawauchi, T. Yamada, M. Tongu, Q. Infei, N. Aoi, I. Morikura, T. Fuchiwaki, F. Takaiwa Izumo, Japan 16.40-18.15 SPACE 2 Workshops August 27, 2013 W6.05.06 - Effective suppression of grass-pollen induced asthma manifestations by subcutaneous and sublingual immunotherapy in a mouse model Laura Hesse, M. Nawijn, R. Gras, H. Oude Elberink, J. Brimnes, A. van Oosterhout Groningen, Netherlands W3.10.02 - Transcriptional regulation of human Th17 cell differentiation Subhash K. Tripathi, Z. Chen, T. Äijö, A. Larjo, V. Salo, S. Tuomela, H. Lähdesmäki, R. Lahesmaa Turku, Finland W3.10.03 - Protein C receptor regulates pathogenic phenotype of Th17 cells Yasuhiro Kishi, C. Wang, C. Wu, N. Yosef, A. Regev, N. Joller, V. Kuchroo Boston, USA Chairs: Franco Locatelli (ITA) Mauricette Michallet (FRA) W6.13.01 - PI3K-independent signal contributes to ICOS-mediated T-cell costimulation in acute GVHD in mice Jun Li, X. Yu Changsha, China 16.40-18.15 SPACE 4 W6.13 - BONE MARROW TRANSPLANTATION AND GRAFT VERSUS HOST DISEASE W6.13.04 - Fetal membrane cells for treatment of steroid-refractory acute GVHD Helen Kaipe, T. Erkers, S. Nava, M. Uzunel, E. Iwarsson, R. Conrad, M. Westgren, J. Mattsson, O. Ringdén Stockholm, Sweden W3.02 - ROLE OF THE STROMA IN INNATE AND ADAPTIVE IMMUNITY W6.13.05 - CMV reactivation and kinetics of NK cell reconstitution in 439 patients after allogeneic hematopoietic stem cell transplantation H. Moins-Teisserenc, Vissal David Kheav, R. Peffault de Latour, M. Busson, C. Scieux, G. Maki, A. Xhaard, G. Socié, A. Toubert, H. Moins-Teisserenc Paris, France IL3.02.01 - Role of Lymph node structure in adaptive immunity to influenza virus M.C. Woodruff, C.H. Herndon, S.S. Turley, Michael C. Carroll Boston, United States W6.13.06 - CD8+ T-cells expressing the homing receptors CCR7 and CD62L mediate the pathogenesis of GVHD A. Kreutzman, Ixaso Sainz Portero, M. Royg, V. Gómez García Soria, A. Ramirez, C. Muñoz Calleja Madrid, Spain W3.10 - Th17 CELLS Chairs: Megan Levings (CAN) Pierre Miossec (FRA) 16.40-18.15 SPACE 4 W3.10.05 - Development and stability of human Th17 cells require endogenous NOS2 and cGMPc/GK-dependent NO signalling N. Obermajer, J. Wong, K. Chen, M. Scott, S. Khader, J. Kolls, K. Odunsi, R. Edwards, T. Billiar, Pawel Kalinski Pittsburgh, USA W3.10.06 - Evidence of a transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of juvenile idiopathic arthritis patients Laura Maggi, L. Cosmi, V. Santarlasci, M. Capone, V. Querci, M. Rossi, F. Liotta, E. Maggi, F. Annunziato, S. Romagnani Florence, Italy W6.13.03 - In vitro-generated myeloid-derived suppressor cells inhibit GVHD while preserving the graftversus-tumor effect Joanna J. Messmann, M.B. Lutz, F. Leithäuser, K.M. Debatin, G. Strauss Ulm, Germany Chairs: Michael C. Carroll (USA) David Naor (ISR) 16.40-18.15 AMBER 1+2 16.40-18.15 SPACE 3 W6.13.02 - CD11b+ NK cells are the main effector NK cell subpopulation that impairs GVHD K. Meinhardt, I. Kroeger, R. Bauer, D. Dudziak, M. Rehli, A. Mackensen, Evelyn Ullrich Frankfurt, Germany W3.10.04 - IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis Magdalena Huber, S. Heink, A. Pagenstecher, K. Reinhard, J. Ritter, A. Visekruna, A. Guralnik, T. Kamradt, M. Lohoff Marburg, Germany IL3.02.02 - Stroma-derived Hyaluronan induces CD44dependent apoptosis in diabetic insulin-secreting cells David Naor, N. Assayag-Asherie, E.A. Turley, I. Raz Jerusalem, Israel W3.02.01 - Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell binding and activation Balthasar A. Heesters, P. Chatterjee, Y. Kim, S.F. Gonzalez, M.P. Kuligowski, T. Kirchhausen, M.C. Carroll Boston, USA IL3.10.01 - Contribution of IL-17 to the chronicity of inflammatory diseases Pierre Miossec Lyon, France W3.02.02 - Dynamics of plasma cell survival niches in the bone marrow S. Zehentmeier, K. Roth, Ö. Sercan, H. Chang, Z. Cseresnyes, R. Niesner, A. Radbruch, Anja E. Hauser Berlin, Germany W3.10.01 - Phosphorylation status determines the divergent roles of Smad2 and Smad3 as STAT3 cofactors in Th17 differentiation Jeong-Hwan Yoon, K. Sudo, S. Park, M. Kuroda, S. Nakae, T. Yamashita, J. Ju, K. Matsuzaki, T. Sumida, M. Mamura Tokyo, Japan W3.02.03 - Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow Julie Tellier, F. Mourcin, C. Breton, P. Narang, L. Chasson, A. Jorquera, M. Coles, S. Mancini, C. Schiff Parkville, Australia 79 16.40-18.15 AMBER 1+2 Workshops August 27, 2013 W5.21 - MYELO - AND LYMPHO-PROLIFERATIVE DISORDERS W3.02.04 - Local complement activation abrogates the tumor-endothelial barrier and mediates T cell homing and tumor immune attack Andrea Facciabene, F. De Sanctis, K. Balint, P. Magotti, J. Lambris, G. Coukos Philadelphia, USA Chairs: Vito Pistoia (ITA) Angelo Vacca (ITA) IL5.21.01 - Cytokines and B cell lymphoproliferative disorders Vito Pistoia, I. Airoldi Genova, Italy W3.02.05 - Alterations in stromal cell compartment during thymus atrophy induced by P. brasiliensis infection Thiago Alves da Costa, R. Di Gangi, C. Francelin, R. Thomé, L. Verinaud Campinas, Brazil W5.21.01 - Variation in B cell receptor signalling between stereotypic and heterogeneous chronic lymphocytic leukemia Alice F. Muggen, L.P. Kil, S. Yuvaraj, J.J.M. van Dongen, R.W. Hendriks, A.W. Langerak Rotterdam, Netherlands W3.02.06 - A quasi clone specific mechanism for the regulation of the size of the primary CD8 T cell response Richard W. Dutton, T. Zou Worcester, USA W5.21.02 - The bone-targeting of IL-27 is mediated by the poly-glutamic acid motif of its p28 subunit Aurélie Jeanne Tormo, L. Beaupré, G. Elson, S. Crabé, J. Gauchat Montreal, Canada W5.14 - PSORIASIS AND SKIN DISEASES W5.21.03 - MIP-1/CCL3-mediated maintenance of leukemia initiating cells in the initiation process of chronic myeloid leukemia Naofumi Mukaida, T. Baba Kanazawa, Japan W5.14.01 - Innate immune activation promotes autoimmune response in generalized pustular psoriasis Akiko Arakawa, S. Vollmer, B. Summer, Y. Kawakami, B. Petra, P. Thomas, A. Wollenberg, J. Schauber, T. Ruzicka, J.C. Prinz. Munich, Germany. 16.40-18.15 AMBER 3+4 W5.14.02 - PD-1 and other new molecules in the psoriatic infiltrate: an immunohistochemical and confocal laser microscopic study Daniele Fanoni, B. Vergani, S. Recalcati, S. Tavecchio, A.V. Marzano, A. Villa, E. Berti Milan, Italy W5.14.03 - Inhibition of keratinocyte differentiation by the synergistic effect of pro-inflammatory cytokines mimics psoriasis Aina Rabeony, I. Paris, J. Garnier, C. Barrault, N. Pedretti, K. Guilloteau, V. Huguier, F. Bernard, J. Lecron, F. Morel Poitiers, France W5.14.04 - In vivo induction of cutaneous inflammation results in the accumulation extracellular trap forming neutrophils expressing RORt and IL-17, while IL-17+ROR+ T cells remain absent R.R.M.C. Keijsers, P.E.J. van Erp, P.C.M. van de Kerkhof, I. Joosten, Hans J.P.M. Koenen Nijmegen, Netherlands W5.14.05 - Skin inflammation in Act1-deficient mice is T cell intrinsic and due to exaggerated Th17 derived IL-22 Ling Wu, C. Wang, V.K. Kuchroo, W. Ouyang, X. Li Cleveland, USA W5.14.06 - Autoreactive T cells in chronic idiopathic urticaria target the high-affinity IgE receptor I subunit (FcRI) Priscilla Auyeung, D. Mittag, P. Hodgkin, L. Harrison Melbourne, Australia 80 16.40-18.15 AMBER 5+6 Chairs: Giampiero Girolomoni (ITA) Andrea Cavani (ITA) W5.21.04 - Detection of de novo IGHV mutations by ultra-deep sequencing from in vitro activated B cell chronic lymphocytic leukemia cells: Evidence for activation-induced deaminase function Charles C. Chu, P.E.M. Patten, T. MacCarthy, X.J. Yan, J.E. Kolitz, S.L. Allen, J.C. Barrientos, K.R. Rai, N. Chiorazzi Manhasset, USA W5.21.05 - Early growth response gene 2 and 3 are essential for the regulation of tumour suppressor genes, Ikaros, Aiolos and FOXO3 Punamdip K. Bhullar, T. Miao, A.L.J. Symonds, E. Ghaffari, S. Li, P. Wang Uxbridge, United Kingdom W5.21.06 - CD27 signalling promotes the proliferation of human acute myeloid leukemia cells Carsten Riether, C. Schürch, A.F. Ochsenbein Bern, Switzerland Workshops August 27, 2013 W1.05 - INNATE LYMPHOCYTES W5.16.02 - A second generation therapeutic cellular vaccine for hepatitis C virus Branka Grubor-Bauk, P. Latour, J. Torresi, W. Yu, S. Roberts, B. Loveland, E. Gowans Adelaide, Australia Chair: Paolo Dellabona (ITA) IL1.05.01 - Functional Education of iNKT Cells by Dendritic Cell Tuning of SHP-1 Paolo Dellabona, A. Napolitano, G. Casorati Milano, Italy W5.16.03 - Gender predominance is mediated via testosterone in a mouse model of autoimmune cholangitis Dorothee Schwinge, A. Carambia, A. Quaas, C. Wegscheid, G. Tiegs, A.W. Lohse, J. Herkel, C. Schramm Hamburg, Germany 16.40-18.15 AMBER 7+8 W1.05.01 - TSLP induces corticosteroid resistance of natural helper cell and evokes severe asthma Kazuyo Moro, H. Kabata, K. Asano, S. Koyasu Yokohama, Japan W1.05.02 - Group 2 innate lymphocytes are critical for Th2 cell-mediated allergic lung inflammation T.Y.F. Halim, L. Matha, C.A. Steer, F. Takei, Itziar Martines Gonzales Vancouver, Canada W5.16.04 - CD49a+DX5- NK cells are liver-resident and confer adaptive immunity in skin-contact inflammation Zhigang Tian, H. Peng, X. Jiang, Y. Chen, D. Sojka, H. Wei, R. Sun, W. Yokoyama Hefei, China W1.05.03 - Identification of IL-17+RORT+CD34+ as lineage-committed progenitors of IL-22+NCR+RORT+ innate lymphoid cells Elisa Montaldo, L.G. Teixeira, L. Moretta, M.C. Mingari, C. Romagnani Genoa, Italy W5.16.05 - Phenotypic evaluation of CD28 negative T cells in primary sclerosing cholangitis Evaggelia Liaskou, L. Jeffery, S. Suresh, P. Trivedi, T. Bruns, D.H. Adams, D.M. Sansom, G.M. Hirschfield Birmingham, United Kingdom W1.05.05 - Reduced MAIT cell frequency associated with enhanced cell death in systemic lupus erythematosus Asako Chiba, N. Tamura, E. Hayashi, R. Matsudaira, T. Yamamura, Y. Takasaki, S. Miyake Tokyo, Japan 16.40-18.15 BROWN 1 W1.05.04 - T-bet is required for the development of NKp46+ innate lymphoid cells via a Notch-dependent pathway Lucille C. Rankin Parkville, Australia W5.16.06 - Tumor-infiltrating IL-10 producing T cells are potent suppressors of the local anti-tumor immunity in patients with liver cancer Alexander Pedroza-Gonzalez, J. Kwekkeboom, E. Vargas-Mendez, C. Verhoef, J. de Jonge, J.N.M. IJzermans, H.L.A. Janssen, D. Sprengers Rotterdam, Netherlands W1.05.06 - The SLAM family receptor Ly9 (CD229) is a negative regulator of marginal zone B cells response Marta Cuenca, X. Romero, J. Sintes, P. Engel Barcelona, Spain W5.16 - LIVER IMMUNOLOGY Chairs: Pietro Invernizzi (ITA) Eli Pikarsky (ISR) 16.40-18.15 BROWN 1 IL5.16.01 - Progress in the genetics and epigenetics of primary biliary cirrhosis Pietro Invernizzi, M. Correnti, C. Mascheroni, A. Lleo, F. Bernuzzi, I. Bianchi Rozzano (MI), Italy IL5.16.02 - Constitutive IKK Activation Promotes Hepatocellular Carcinoma via Formation of Inflammatory Micro-niches Eli Pikarsky, S. Finkin, D. Yuan, I. Stein, K. Taniguchi, K. Rajewsky, M. Karin, Y. Ben-Neriah, M. Heikenwalder Jerusalem, Israel W5.16.01 - IL-17A produced by T cells promotes tumor growth in hepatocellular carcinoma S. Ma, Q. Cheng, Y. Cai, Y. Wu, X. Yu, Haiyan Liu Suzhou, China 81 Posters Posters Session Posters - August 23 Panel N° P1.01 GRANULOCYTES Session Time: Friday, August 23, 13:20 -15:00 001 P1.01.01 - A defect in granulopoiesis in perforin-deficient mice Cassio C. Almeida, M.I.C. Gaspar-Elsas, T. Queto, B. Vieira, T. Vieira, D.M. Brito, P.P. Xavier-Elsas; Rio de Janeiro, Brazil 002 P1.01.02 - Different anti-HSP70 antibodies detect different dynamics of intracellular HSP70 content in heat shocked human neutrophils Anna Boyko, O. Shustova, A. Klinkova, A. Sapozhnikov, E. Kovalenko; Moscow, Russian Federation 003 P1.01.03 - Role of CD63, CD11b and CD14 as potential markers of granule release induced by propionate in bovine neutrophils Rafael A. Burgos, M.D. Carretta, M.A. Hidalgo; Valdivia, Chile 004 P1.01.04 - Photoconversion and in vivo imaging reveal a role for neutrophils in regulating adaptive immune responses H.R. Hampton, J. Bailey, M. Tomura, R. Brink, Tatyana Chtanova; Darlinghurst (Sydney), Australia 005 P1.01.05 - Different role of nitric oxide on adhesiveness and apoptosis of inflammatory granulocytes after burn injury Biljana Draskovic-Pavlovic, D. Vucevic, I. Majstorovic, B. Bozic, G. Zunic, M. Colic; Belgrade, Serbia 006 P1.01.06 - Glucocorticoid-induced leucine zipper (GILZ) promotes apoptosis in vitro in neutrophil-like cells Marie-Alix Espinasse, P. Piednoir, G. Dufour, P. Montravers, S. Chollet-Martin, M. Pallardy, A. Biola-Vidamment; Chatenay Malabry, France 007 P1.01.07 - In vivo induction of Neutrophil Extracellular Traps by Mycobacterium tuberculosis Georgina Filio-Rodriguez, I. Estrada, P. Arce-Paredes, S. Islas-Trujillo, B. Moreno-Altamirano, O. Rojas-Espinosa; Mexico City, Mexico 008 P1.01.08 - Activation of phagocytosis by a low molecular fraction (below 5 kDa) from cord blood in leukocytes after hypothermic storage or cryopreservation Anatoliy N. Goltsev, N.N. Moiseyeva, O.L. Gorina, J.S. Akhatova; Kharkov, Ukraine 009 P1.01.09 - Chemerin aggravates DSS-induced colitis associated with defective protective innate responses Rui He, Y. Lin, X. Yang, W. Yue, L. Zou, B. Li; Shanghai, China 010 P1.01.10 - Neutrophils as potential biomarkers in the differentiation of multiple sclerosis and neuromyelitis optica Laura Hertwig, N. Borisow, K. Stürner, B. Seeger, C. Infante Duarte, F. Paul; Berlin, Germany 011 P1.01.11 - Kinase activity profiling of polymorphonuclear cells in critically ill patients Arie J. Hoogendijk, G.M. Fuhler, L.A. van Vught, M.A. Wiewel, H. Belkasim, M.A.M. Huson, B.P. Scicluna, J. Horn, M.J. Schultz, T. van der Poll; Amsterdam, Netherlands 012 P1.01.12 - The role of neutrophils upon infection with the protozoan parasite Leishmania mexicana in C57BL/6 mice Benjamin Hurrell, S. Schuster, J. Alexander, M. Malissen, F. Tacchini-Cottier; Epalinges, Switzerland 013 P1.01.13 - Intercellular ROS signaling in granulocyte-mediated tumor cell destruction Morana Jaganjac, T. Matijevic, G. Bauer, R.J. Schaur, A.A. Latiff, N. Zarkovic; Doha, Qatar 014 P1.01.14 - Cyclophilin A stimulates recovery of the hematopoietic and the immune system of the organism after radiotherapy Anastasia Kalinina, N. Kulikova, D. Kazansky, Y. Silaeva, L. Khromykh; Moscow, Russian Federation 015 P1.01.15 - Effect of colchicine on expression of inflammation-related genes in neutrophils from healthy subjects and patients with familial Mediterranean fever Gayane Manukyan, M. Petrek, A. Martirosyan, Z. Navratilova, E. Kriegova; Yerevan, Armenia 016 P1.01.16 - Cross-talk between neutrophils and Pseudomonas aeruginosa biofilm. Role of MPO-halide system products Janusz Marcinkiewicz, M. Strus, M. Walczewska, E. Pasich, M. Ciszek-Lenda, A. Machul, D. Mikołajczyk; Kraków, Poland 017 P1.01.17 - Role of 5-lypoxygenase in the regulation of eosinophilopoiesis Daniela Masid-de-Brito, P.P. Xavier-Elsas, R.A. Luz, R. Lopes, C. Almeida-Da Silva, K. Pinnola, R. Ferreira, M.C. Gaspar-Elsas; Rio de Janeiro, Brazil 018 P1.01.18 - The p38-MSK1 signaling cascade influences cytokine production through bZIP transcription factors in human neutrophils Patrick P. McDonald, T.Z. Mayer, F.A. Simard, A. Cloutier; Sherbrooke, Canada 019 P1.01.20 - IL-4 derived from basophil play a pivotal role in cysteine protease-induced natural helper cell-mediated lung inflammation Yasutaka Motomura, H. Morita, K. Moro, S. Nakae, S. Koyasu, M. Kubo; Noda, Japan 83 Posters - August 23 020 P1.01.22 - The Dectin-1 ligand Beta-glucan triggers neutrophil extracellular trap (NET) formation via a signaling pathway requiring Src-family kinases and Syk Giorgio Berton Verona, Italy 021 P1.01.23 - Effects of proton pump inhibitors and H2-antagonists on neutrophil oxidative metabolism in patients with gastric and duodenal ulcer bleeding Natalia S. Obraztsova, O.N. Sulaieva, V.Y. Delii, S.O. Zarikov; Donetsk, Ukraine 022 P1.01.24 - IgE-armed basophils and their skin-infiltration are essential for acquired tick resistance Takuya Ohta, S. Yoshikawa, K. Ishiwata, K. Horiguchi, L. LI, Y. Kawano, H. Kanuka, N. Watanabe, Y. Minegishi, H. Karasuyama; Tokyo, Japan 023 P1.01.25 - IL-17A differential effects in murine bone marrow granulopoiesis in presence of GM-CSF or IL-5 in vitro Lysianne Pinto, T. Queto, D.M. Brito, C.L. Coutinho, B. Luca, B.M. Vieira, J.C. Alves Filho, F.Q. Cunha, M.I.C. Gaspar-Elsas, P.P. XavierElsas; Rio de Janeiro, Brazil 024 P1.01.26 - Effect of testosterone on the activity of inflammatory cells Amado Quintar, C. Leimgruber, N. Peinetti, C. Maldonado; Cordoba, Argentina 025 P1.01.27 - Reveiling the death pathway leading to eosinophil cytolysis Susanne Radonjic-Hoesli, C. Stoeckle, D. Simon, B. Styp-Rekowska, R. Hlushchuk, S. Yousefi, H. Simon; Bern, Switzerland 026 P1.01.28 - Basophils control T cell responses and limit disease activity in Experimental Murine Colitis Manuel Rodriguez Gomez, F. Hermann, K. Claudia, Y. Talke, I. Ketelsen, B. Reich, K. Renner, S. Syed, H. Bruehl, M. Mack; Regensburg, Germany 027 P1.01.29 - Sympathoadrenergic modulation of human neutrophils Angela Scanzano, L. Schembri, E. Rasini, R. Bombelli, M. Legnaro, A. Luini, M. Cosentino, F. Marino; Varese, Italy 028 P1.01.30 - Role of neutrophils in neovessel formation in atherosclerotic lesions: preliminary evidence in patients with carotid plaque Laura Schembri, A. Scanzano, M. Tozzi, E. Rasini, M. Legnaro, A. Luini, M. Cosentino, F. Marino; Varese, Italy 029 P1.01.31 - Blockage of histamine receptor 2 ameliorates the progression of sepsis in NOD diabetic mice Gabriela T. Scortegagna, P.H. Melo, D. Nascimento, V. Borges, F.O. Souto, D. Carlos, F.Q. Cunha; Ribeirão Preto, Brazil 030 P1.01.32 - Entry of Staphylococcal Superantigen-Like Protein 11 into neutrophils attenuating their recruitment Richard P. Sequeira, R.J. Langley, T. Proft, J.D. Fraser; Auckland, New Zealand 031 P1.01.33 - Effect of exercise on cytokine production by neutrophils Irina Shvydchenko, E. Bykovskaya, V. Romenskaya, G. Rozhkova, A. Simbirtsev; Krasnodar, Russian Federation 032 P1.01.34 - Role of nanoparticles in apoptosis and cytoskeleton rearrangement in human leukemia eosinophil like AML 14.3D10 cells Jean-Christophe Simard, F. Vallières, D. Girard; Laval, Canada 033 P1.01.35 - Orai1-mediated Ca2+ influx independent of SOCE is essential for LPS and C5a-induced neutrophil migration in acute inflammation Georgios Sogkas, T. Vögtle, B. Nieswandt, R. Schmidt, E. Gessner; Hannover, Germany 034 P1.01.36 - Soluble molecules from Trypanosoma cruzi are able to induce NETosis from human neutrophils in the absence of classical apoptosis and necrosis signals L.F.A. Diniz, P.S.S. Souza, M. Thomaz-Tobias, D. Sousa-Rocha, M.F. Costa, Karina A. Toledo; Assis, Brazil 035 P1.01.37 - Role of PI3K, PKC and ERK on neutrophil extracellular trap release induced by Leishmania amazonensis Thiago S.S. Vieira, A. Guimarães-Costa, M.T.C. Nascimento, R. Mariante, E.M. Saraiva; Rio de Janeiro, Brazil 036 P1.01.39 - Critical roles of DOCK2 and DOCK5 in neutrophil chemotaxis, ROS production, and NETs formation Mayuki Watanabe, A. Nishikimi, M. Terasawa, J. Côté, Y. Fukui; Fukuoka, Japan 037 P1.01.40 - Untouched isolation of functionally unaffected neutrophils from whole blood within 20 minutes C. Zyntek, J. Schmitz, Gregor Winkels; Bergisch Gladbach, Germany 84 Posters - August 23 P1.02 MAST CELLS Session Time: Friday, August 23, 13:20 -15:00 038 P1.02.01 - Role of mast cells and histamine in local reaction induced by Potamotrygon motoro stingray venom in mice L.F. Kimura, J.P. Prezotto-Neto, M.M. Antoniazzi, S. Jared, C.F. Teixeira, M.L. Santoro, Katia C. Barbaro; São Paulo, Brazil 039 P1.02.02 - Cross reactivity of IL-3 between mouse and rat in the induction of mouse bone marrow derived mast cells J. Lee, K. Shin, C. Kim, K. Joo, Sung-Weon Cho; Seoul, Korea, Republic of 040 P1.02.03 - OX40L-STIMulated inhibition of mast cell calcium influx Federica D’Incà, J. Almering, B. Frossi, H. Sandig, M. Freichel, S. Bulfone-Paus, C. Pucillo; Udine, Italy 041 P1.02.04 - Augmenting the effects of vaccine adjuvants by targeting mast cells Yu Fang, N. Lycke, Z. Xiang; Guiyang, China 042 P1.02.05 - Generation of mast cells from murine fetus liver and transcriptome analysis using next generation sequencer; a comparison of the profiles between bone marrow derived mast cells with fetus liver derived mast cells Nobuyuki Fukuishi, Y. Igawa, T. Kunimi, N. Matsui, M. Akagi; Tokushima, Japan 043 P1.02.06 - Mast cells induce invariant Natural Killer T cells to cytokine secretion and proliferation via CD1d: Another path to asthma? Nestor Gonzalez Roldan, S. Bulfone-Paus; Borstel, Germany 044 P1.02.07 - Mast cell CYP27B1 hydroxylase activity is required for 25OH vitamin D3-induced suppression of IgE-mediated activation Michele A. Grimbaldeston, K. Yip, C. Yu, N. Kolesnikoff, H. Taing, D. Goltzman, P.H. Anderson, M. Samuel, A. Lopez; Adelaide, South Australia, Australia 045 P1.02.08 - IgE-mediated allergic responses in human mast cells in humanized NOG mice expressing human IL-3 and GM-CSF Ryoji Ito, T. Takahashi, I. Katano, K. Kawai, S. Nunomura, C. Ra, A. Mori, S. Aiso, M. Ito; Kawasaki, Japan 046 P1.02.09 - Roles of basophils and mast cells infiltrating the lung in murine asthmatic responses induced by multiple antigen challenges Haruka Kida, A. Takiguchi, H. Wakamori, K. Ishihara, S. Akiba, N. Mizutani, S. Yoshino, D.D. Chaplin, S. Ohya, T. Nabe; Kyoto, Japan 047 P1.02.10 - Immune suppression following exposure to UV-radiation is associated with increases in mast cell densities in primary and secondary lymphoid tissues Lai Fong Kok, C. Beuagie, C. Chan, S. Sarchio, G. Halliday, S. Byrne; Sydney, Australia 048 P1.02.11 - Intravenous injection of particulate antigens larger than the intracellular gap of endothelial cells can induce mast cell-mediated systemic anaphylaxis Lihua Li, S. Yoshikawa, K. Horiguchi, T. Ohta, H. Deki, Y. Kawano, H. Karasuyama; Tokyo, Japan 049 P1.02.12 - The development of oral tolerance is inhibited by TLR2 agonists but not by IgE-mediated mast cell activation M. Tunis, I. Haidl, Jean S. Marshall; Halifax, Canada 050 P1.02.13 - Notch1 signaling confers antigen-presenting functions on mast cells Nobuhiro Nakano, C. Nishiyama, H. Yagita, K. Okumura, H. Ogawa; Tokyo, Japan 051 P1.02.15 - Involvement of transcription factors PU.1, GATA1 and GATA2 in the expression and function of human FcepsilonRI on mast cells Chiharu Nishiyama, E. Inage, K. Kasakura, T. Yashiro, M. Hara, H. Saito, T. Shimizu, H. Ogawa, K. Okumura; Tokyo, Japan 052 P1.02.16 - Identification of a molecule critical for degranulation of mast cells and anaphylactic reaction Kana Ogawa, Y. Tanaka, Y. Fukui; Fukuoka, Japan 053 P1.02.17 - C. albicans phagocytosis by mast cells via Toll like receptor-2: protection or immune escape? Karen H. Pinke, H.G. Lima, F.Q. Cunha, V.S. Lara; Bauru, Brazil 054 P1.02.18 - Deciphering the molecular immunobiology of anaphylactic shock - and the de novo paradigm shift Peter N. Pushparaj, L.A. Damiati, S.D. Kumar, J. Manikandan, M.H. Al-Qahtani; Jeddah, Saudi Arabia 055 P1.02.20 - The potential role of mast cells in the C-protein induced myositis model Kichul Shin, J. Choi, S. Jang, Y. Song; Seoul, Korea, Republic of 056 P1.02.21 - IgE by itself affects, directly and indirectly, mast cell effector functions Aleksandra Słodka, E. Bąbolewska, P. Witczak, E. Brzeziłska-Błaszczyk; Łódź, Poland 85 Posters - August 23 057 P1.02.22 - Mast cells play a crucial role in non-IgE mediated experimental allergic enteropathy Masako Toda, M. Burggraf, H. Nakajima-Adachi, S. Hachimura, D. Dombrowicz, J. Kirberg, H. Kiyono, G. Hermann-Josef, S. Vieths; Langen, Germany 058 P1.02.23 - Mast cells support in vitro differentiation of Th17 cells Aurelia Walczak-Drzewiecka, M. Ratajewski, J. Dastych; Lodz, Poland 059 P1.02.24 - Maturation of mast cells by Wnt family proteins Tomoko Yamaguchi, K. Tashiro, H. Mizuguchi, K. Kawabata; Osaka, Japan P1.06 MACROPHAGES Session Time: Friday, August 23, 13:20 -15:00 060 P1.06.01 - T cell derived IL-3 enhances the pro- and anti-inflammatory properties of human macrophages dependent of the activation status Ronald M. Allen, N.A. Kittan, S. Mukherjee, A. Dhaliwal, S.L. Kunkel, C.M. Hogaboam; Ann Arbor, United States 061 P1.06.02 - Dissociation of innate immune responses in microglia infected with Listeria monocytogenes limits activation and neuronal damage Carmen Alvarez-Dominguez, E. Rodriguez-Del Rio, M. Lopez-Fanarraga; Santander, Spain 062 P1.06.03 - Copper nanoparticles inhibit LPS-mediated nitric oxide and IL-12p40 production in macrophages A. Barrientos, Sergio Arancibia; Santiago, Chile 063 P1.06.04 - Impact of acute and chronic stress on innate immune system in elderly Sarra Baëhl, G. Dupuis, D. Lorrain, F. Cabana, I. Viens, A. Svotelis, T. Fülöp; Sherbrooke, Canada 064 P1.06.05 - Modulation by lipoxin of tumor-associated macrophages profile Raphael Lourelro Simões, N.M. de Brito, I.M. Fierro Rio de Janeiro, Brazil 065 P1.06.06 - The tyrosine kinase Abl is a component of macrophage podosomes and is required for podosome formation and macrophage migration A. Baruzzi, S. Remelli, Giorgio Berton; Verona, Italy 066 P1.06.07 - Oncogene-induced senescence in histiocytes: role of BRAFV600E in the pathogenesis of Erdheim-Chester disease Riccardo Biavasco, M. Cangi, L. Pecciarini, G. Grassini, G. Cavalli, C. Campochiaro, B. Guglielmi, M. Ferrarini, C. Doglioni, L. Dagna; Milan, Italy 067 P1.06.08 - Jacalin drives macrophage polarization toward an anti-tumor M1-like phenotype Gabriela S. Bisson, C.D. Polli, T.H. Geraldino, L.C. Veronez, L.P. Ruas, M.C. Roque-Barreira; Ribeirão Preto, Brazil 068 P1.06.09 - Modulation of NKG2D and NKG2A ligands expression during monocyte differentiation Giorgio Camilli, F. Paladini, A. Cassotta, R. La Scaleia, S. Battella, M. Fiorillo, G. Palmieri, A. Santoni, R. Sorrentino; Rome, Italy 069 P1.06.10 - Decoy receptor 3 enhances tumor progression via induction of tumor-associated macrophages S.K. Tai, Hsin C. Chang, K.L. Lan, C.T. Lee, C.Y. Yang, N.J. Chen, T.Y. Chou, D.C. Tarng, S.L. Hsieh; Taipei, Taiwan 070 P1.06.11 - PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis Hui-Hsin Chang, S. Miaw, W. Tseng, Y. Sun, C. Liu, H. Tsao, I. Ho; Boston, United States 071 P1.06.12 - Triggering receptor expressed on myeloid cells-1 regulates macrophage polarization in an obstruction-induced nephritis mouse model T. Luo, K. Tseng, W. Tsao, P. Lee, S. Hsieh, A. Chiu, T. Takai, T. Mak, D. Tarng, Nien-Jung Chen; Taipei, Taiwan 072 P1.06.13 - Polarized activation phenotypes of spontaneously differentiated human monocyte-derived macrophages: role of dexamethasone Andrea Cignarella, A. Toniolo, S. Tedesco, C. Bolego; Padova, Italy 073 P1.06.14 - Influence of the phagocytizing mononuclear system (PMS) stimulation on liver and kidney regeneration Irina Danilova, S. Medvedeva, I. Gette; Ekaterinburg, Russian Federation 074 P1.06.15 - Modulation of macrophage function by growth hormone Maria D. dos Santos Reis, Y.M.O. dos Santos, L.F.A. Vieira, A.R.A. Brandão, I.M.M.N. Viana, S. Smaniotto; Rio de Janeiro, Brazil 075 P1.06.16 - The overexpression of glucocorticoid-induced leucine zipper (GILZ) protein in macrophages enhance lifetime in mouse septic shock model Mehdi Ellouze, F. Capel, O. Robert, A. Cassard-Doulcier, G. Perlemuter, M. Pallardy, F. Bachelerie, D. Emilie, V. Godot; Clamart, France 86 Posters - August 23 076 P1.06.17 - CD200R-dependent regulation of monocytes is subset- and tissue specific Mika A. Falck-Hansen; London, United Kingdom 077 P1.06.18 - Study of aminoacidic sequences of vitamin D binding proteins involved in macrophage activation Maria Giulia Fiore, S. Magherini, M. Gulisano, S. Pacini, M. Ruggiero; Firenze, Italy 078 P1.06.19 - Characterization of the murine CD163 receptor Lena Fischer-Riepe, K. Barczyk, D. Holzinger, M. Wolf, J. Roth; Muenster, Germany 079 P1.06.20 - Effects of biodegradable polylactic acid fibers and dexamethasone on classical and alternative activation pathways in macrophages Mari Hämäläinen, E.L. Paukkeri, A. Pekurinen, R. Nieminen, M. Kellomäki, T.L.J. Tammela, M. Talja, E. Moilanen; Tampere, Finland 080 P1.06.22 - Thymic cortical dendritic macrophages (TCDMs); professional scavengers of apoptotic thymocytes in the human thymus Atsushi Hayashi, Y. Miki, Y. Gion, K. Takahashi; Okayama, Japan 081 P1.06.23 - Tissue macrophages arise from fetal liver monocytes during late embryonic development Guillaume Hoeffel, J. Chen, P. See, D. Low, F. Almeida, D. Hashimoto, M. Merad, M. Poidinger, F. Ginhoux; Singapore, Singapore 082 P1.06.24 - Fighting chronic inflammation - CD64-specific elimination of M1 macrophages Dmitrij Hristodorov, R. Mladenov, V. von Felbert, M. Huhn, R. Fischer, S. Barth, T. Thepen; Aachen, Germany 083 P1.06.25 - The functional fate of human monocytes after engagement of various pattern recognition receptors Daniela C. Ifrim, J. Quintin, L.A.B. Joosten, N.A.R. Gow, D.L. Williams, J.W.M. van der Meer, M.G. Netea; Nijmegen, Netherlands 084 P1.06.26 - Intracellular chloride channel protein CLIC1 regulates macrophage functions via modulation of phagosomal acidification Lele Jiang, K. Salao, H. Li, J.M. Rybicka, R.M. Yates, D.A. Brown, L.J. Brown, P.M.G. Curmi, S.N. Breit; Sydney, Australia 085 P1.06.28 - Intestinal epithelial cell-derived Semaphorin 7A negatively regulates development of colitis via αvβ1 integrin Sujin Kang, A. Kumanogoh; Suita, Japan 086 P1.06.30 - The effects of silica nanoparticles in macrophage cells SeungJae Kim, I. Choi; Seoul, Korea, Republic of 087 P1.06.31 - Alternatively Activated Macrophages - Cause or Consequence in Allergic Airway inflammation? Frank Kirstein, N. Nieuwenhuizen, F. Brombacher; Cape Town, South Africa 088 P1.06.32 - MyD88 and Stat3 signaling are fundamental to tumor associated macrophage function Franz Kratochvill, J.E. Qualls, L. Van De Velde, P. Kovarik, P.J. Murray; Memphis, United States 089 P1.06.33 - SHP-1/Src protein complex differentially regulates IL-12 and IL-23 cytokines in TLR4-activated signaling pathways in human macrophages Ashok Kumar, Y. Konarski, A. Busca, M. Kozlowski; Ottawa, Canada 090 P1.06.34 - DMXAA, a vascular disruptive agent, is a potent inhibitor of prostaglandin synthesis Etsushi Kuroda, K. Ohata, K.J. Ishii; Suita, Japan 091 P1.06.35 - Myeloid cell expressed proprotein convertase Furin attenuates inflammation Zuzet Martinez Cordova, A. Oksanen, S. Hämäläinen, V. Taverniti, I. Junttila, M. Pesu; Tampere, Finland 092 P1.06.36 - The marine natural product Honaucin A inhibits innate inflammation Samantha Mascuch, H. Choi, F. Villa, M. Hensler, J. Olson, V. Nizet, F. Mahdi, D.G. Nagle, W. Gerwick, L. Gerwick; La Jolla, United States 093 P1.06.37 - Differential effect of cyanobacterium Anabaena sp. lipopolysaccharide (LPS) on rat brain microglia-derived proinflammatory and anti-inflammatory cytokines and chemokines Alejandro M. Mayer, D. Macadam, M.L. Hall, D. Feher, P. Williams; Downers Grove, United States 094 P1.06.38 - Pulmonary surfactant protein A strengthens IL-4-mediated proliferation and alternative activation of rat alveolar macrophages Carlos Minutti, B. García-Fojeda, C. Casals; Madrid, Spain 095 P1.06.39 - Characterization of the innate immune response in human macrophages by Mycobacterium bovis BCG Gabriela Molina-Olvera, A.I. Castllo-Rodal, Y. López-Vidal; México, Mexico 87 Posters - August 23 096 P1.06.40 - Regulation of macrophage complement receptor immunoglobulin (CRIg) expression by cytokines Usma Munawara, A. Quach, N.N. Gorgani, C. Abbott, A. Ferrante; Adelaide, Australia 097 P1.06.41 - Ubiquitin-like protein MNSFβ covalently binds to Bcl-G and enhances lipopolysaccharide (LPS)/interferon γ (IFNγ)-induced apoptosis in macrophages Morihiko Nakamura, M. Nakagawa; Izumo, Japan 098 P1.06.42 - T CD8+ suppressor lymphocyte-derived exosomes carrying miRNA150 impair macrophage ability to induce humoral immune response in mice Katarzyna Nazimek, M. Ptak, W. Ptak, K. Bryniarski; Krakow, Poland 099 P1.06.43 - The role of MAP kinase phosphatase-2 (MKP-2) in macrophage development and gene expression Thikryat Neamatallah, J. Schroeder, R. Tate, J. Alexander, R. Plevin; Glasgow, United Kingdom 100 P1.06.44 - Differential regulation of innate immunity in the lungs of smokers and non-smokers Johan Öckinger, M. Hagemann-Jensen, S. Kullberg, A. Eklund, J. Grunewald, J. Wahlström; Stockholm, Sweden 101 P1.06.45 - Notch Signaling Regulates Expression of Mcl-1 and Apoptosis in PPD-treated Macrophages Tanapat Palaga, S. Ratanabunyong, T. Pattarakankul, Y. Hadae, N. Sangphech, P. Kuenjinda; Bangkok, Thailand 102 P1.06.46 - Evaluation of the potency of CD137-activated macrophages in inhibiting tumor cell growth Wan Lu Pang, H. Schwarz; Singapore, Singapore 103 P1.06.47 - Statins mediate protection against Mycobacterium tuberculosis infection by enhancing phagosomal maturation and autophagy Suraj P. Parihar, R. Guler, R. Khutlang, D. Lang, M. Mhlanga, H. Suzuki, D. Marais, F. Brombacher; Cape Town, South Africa 104 P1.06.48 - Metalloproteinase-9 production by monocytes from cutaneous leishmaniasis patients Sara Passos, T. Menezes, R. Costa, E.M. Carvalho, L.P. Carvalho; Salvador, Brazil 105 P1.06.49 - The importance of experimental milieu in regulation of macrophage activation Michaela Pekarova, A. Lojek, H. Martiskova, A. Klinke, T. Rudolph, M. Maceckova, R. Kuchta, J. Kadlec, Z. Kuchtova, L. Kubala; Brno, Czech Republic 106 P1.06.50 - The interaction of monocytes from Sjögren Syndrome patients with human salivary gland epithelial cells promotes an inflammatory microenvironment modulated by VIP V. Hauk, L. Fraccaroli, E. Grasso, A. Eimon, R. Ramhorst, O. Hubscher, Claudia Perez-Leiros; Buenos Aires, Argentina 107 P1.06.51 - Contribution of microRNAs to human macrophage polarization processes Matthieu Pesant, G. Sukubo, M. Locati; Rozzano, Italy 108 P1.06.53 - Altered Expression of CD200/CD200R1 Immunoinhibitory Proteins is Associated with the Dysregulated Microglial Response to Ischemic Stroke Injury in Aged Mice Rodney M. Ritzel, A. Patel, V. Scranton, L. McCullough, F. Liu; Farmington, United States 109 P1.06.54 - Age-and Location-Related Changes in the Immunoregulatory Status of Microglia Rodney M. Ritzel, A.R. Patel, F. Liu, L.D. McCullough; Farmington, United States 110 P1.06.55 - Modulation of FcgammaRs expression in macrophages derived from THP-1 cells (THP-1-MΦ) polarized to inflammatory, wound-healing and regulatory phenotypes Ana Diana Rivera Fuentes, E. Ortega Soto; Mexico, Mexico 111 P1.06.56 - Non-classical circulating monocytes are reduced in patients with systemic lupus erythematous (SLE) and they show regulatory functions on classical monocytes in healthy controls C. Burbano-Arciniegas, G. Vasquez-Duque, Mauricio Rojas-Lopez; Medellín, Colombia 112 P1.06.57 - Isolation of mouse alveolar macrophage using mixed primary culture from lungs P.M.C. Silva, I.T. Brandão, A.P. Masson, W.M. Rios, R.F. Rodrigues, C.L. Silva, Rogerio S. Rosada; Ribeirão Preto, Brazil 113 P1.06.58 - Mac-1 controls the pro-inflammatory phenotype of type 1 macrophages Kim C.M. Santegoets, M.H. Wenink, D.M. Lundvig, L. van Bon, A. Cambi, R.A. Benson, I. McInnes, W.B. van den Berg, F.A. Wagener, T.R.D.J. Radstake; Utrecht, Netherlands 114 P1.06.59 - The immunomodulatory effect of propolis and chlorhexidine on cytokine production by human monocytes Karina B. Santiago, B.J. Conti, E.O. Cardoso, J.M. Sforcin; Botucatu, Brazil 115 P1.06.60 - Polyporus alveolaris extract (PAE) have the ability to stimulate macrophages against tumor with unique manner Yasutaka Sasajima, M. Kawamura, T. Aradate, A. Muraguchi, T. Katagiri; Toyama city, Japan 88 Posters - August 23 116 P1.06.61 - Realtime analysis of monocyte migration in 3D synovial micromass tissue cultures Clemens Scheinecker, R. Byrne, K. von Dalwigk, A. Hladik, J.S. Smolen, H. Kiener; Wien, Austria 117 P1.06.62 - The sulfation level of glycosaminoglycans in monocytes and macrophages Maria Schönberg, U. Obeck, J. Flemmig, J. Arnhold; Leipzig, Germany 118 P1.06.63 - IRF8 and IRF3 cooperatively regulate rapid interferon-β induction in human blood monocytes P. Li, J. Wong, C. Sum, Wei-Xiang Sin, K. Chin; Singapore, Singapore 119 P1.06.64 - Resolving inflammation: M2 macrophages contribute to the resolution of postoperative ileus Kathy Stein, M. Lysson, S. Wehner, J. Kalff; Bonn, Germany 120 P1.06.65 - CX3CR1+ monocytes support P. gingivalis survival Orit Steinmetz, S. Hoch, L. Eli-Berchoier, G. Nussbaum; Jerusalem, Israel 121 P1.06.66 - Identification of RORC as regulator of polarized inflammation Laura Strauss, G. Szebeni, S. Morlacchi, M.G. Totaro, A. Bruno, D. Noonan, A. Anselmo, S. Sangaletti, M. Colombo, A. Sica; Rozzano (MI), Italy 122 P1.06.67 - Role of macrophages reaction in pathogenesis of duodenal ulcer bleeding Oksana N. Sulaieva; Donetsk, Ukraine 123 P1.06.68 - Effect of phytoestrogens on helper T cell and macrophage differentiation Masaya Takamoto; Matsumoto, Japan 124 P1.06.69 - Immune-modifying particles inhibit inflammatory monocyte migration to the central nervous system and improve outcomes in experimental autoimmune encephalomyelitis Rachael L. Terry, D.R. Getts, N.J.C. King, S.D. Miller; Chicago, United States 125 P1.06.70 - E.coli upregulates CD39 expression in RAW264.7 macrophages Gábor Tör , B. Koscsó, B. Csóka, L. Virág, G. Haskó; Debrecen, Hungary 126 P1.06.71 - Pulmonary GM-CSF regulates alveolar macrophage population size and function via a reciprocal feedback mechanism Bruce C. Trapnell, T. Suzuki; Cincinnati, United States 127 P1.06.72 - Effect of CCL1 depletion on the tumoricidal monocyte generation in cultures of peripheral blood monocytes derived from patients with hepatocellular carcinoma (HCC) A. Asai, Yusuke Tsuchimoto, H. Ohama, S. Fukunishi, Y. Tsuda, A. Fukuda, M. Kobayashi, K. Higuchi, F. Suzuki; Takatsuki, Osaka, Japan 128 P1.06.73 - Regulation of complement receptor immunoglobulin (CRIg) expression in human macrophages by protein kinase Cα Kanchana Usuwanthim, Y. Ma, N.N. Gorgani, C. Hii, A. Ferrante; Adelaide, Australia 129 P1.06.74 - Modulation of phagocytosis in Mononuclear Phagocyte Cells by IL-21: Involvement of Spleen Tyrosine Kinase (Syk) Francis Vallières, D. Girard; Laval, Canada 130 P1.06.75 - Characterization of central macrophages in Anemia of Inflammation (AI): African trypanosomiasis as a model system Liese Vansintjan, B. Stijlemans, S. Philipsen, P.J.M. Leenen, P. De Baetselier; Brussels, Belgium 131 P1.06.76 - The immunomodulatory activity of glycerophosphoinositols Mariangela Vessichelli, P. Italiani, S. Mariggiò, P. Zizza, V. Evangelista, D. Boraschi, D. Corda; napoli, Italy 132 P1.06.77 - Salmonella autophagy Tzu-Yuan Wang, C. Chiu; Taoyuan, Taiwan 133 P1.06.78 - Regulation of myogenesis by differentially activated macrophages during human skeletal muscle regeneration Houda Yacoub-Youssef, M. Saclier, A. Mackey, L. Arnold, J. Chelly, R. Mounier, M. Kjaer, B. Chazaud; Paris, France 134 P1.06.79 - The role of a novel DEAD-box protein in LPS-induced NLRP3 inflammasome activation Chih-Hsiang Yang, S. Hsu, Y. Lai, L. Hsu; Taipei, Taiwan 135 P1.06.80 - Necrotic cells induce CD14-/CD68+ peritoneal exudate cells to proliferate and differentiate into macrophage-like cells Xiaolin Yuan, X. Li, Q. Zhang, C. Zhang, D. Li; Dalian, China 89 Posters - August 23 136 P1.06.81 - The Effect of Polyporus umbellatus(Chinese medicine)on LPS-induced Viability and Cytokine Expression in RAW264.7 cells Xing Zeng; Guangzhou, China 137 P1.06.82 - Suppression of PTRF inhibits TLR4 signaling: a novel regulator of sepsis Yijie Zheng, X. Liang, S. Wei, H. Moon, Y. Jin; Boston, United States P1.11 TOLL-LIKE AND PATTERN RECOGNITION RECEPTORS Session Time: Friday, August 23, 13:20 -15:00 138 P1.11.001 - Neuinflam9/Toxo1 regulates the innate immune response after nerve injury and susceptibility to autoimmune neuroinflammation in rat Nada Abdelmagid, F. Al Nimer, J. Öckinger, R. Lindblom, X. Zhang, S. K. Bedri, A. Saoudi, G. Fournié, T. Olsson, M. Jagodic, F. Piehl, M. Diez; Stockholm, Sweden 139 P1.11.002 - The Toll-IL-1R member Tir8 modulates post-transplant kidney ischemia/reperfusion injury by inhibiting resident leukocyte expansion P. Cassis, Sistiana Aiello, N. Azzollini, S. Solini, G. Remuzzi, M. Noris; Ranica, Italy 140 P1.11.003 - Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis Adam A. Anas, M.H.P. van Lieshout, S. Florquin, B. Hou, A.L. DeFranco, C. van t. Veer, A.F. de Vos, T. van der Poll; Amsterdam, Netherlands 141 P1.11.004 - Activation and regulation of Toll-like receptors by infestation with Rhipicephalus sanguineus ticks Elen Anatriello, L.C. Ribeiro, I. Bueno, M.S.L. Nascimento, L.A. Sacramento, C.J. Oliveira, J.S. da Silva, I.K.F.d. Santos, B.R. Ferreira; University of São Paulo, Ribeirão Preto, Brazil 142 P1.11.006 - Role of TIR8/SIGIRR in regulating TLR and IL-1R like-dependent platelet activation Achille Anselmo, C. Soldani, C. Soldani, S. Gentile, S. Gentile, M. Bacci, M. Bacci, A. Voza, A. Voza, M. Nebuloni, M. Nebuloni, L. Mendolicchio, L. Mendolicchio, A. Mantovani, A. Mantovani, F. Riva, F. Riva, C. Garlanda, C. Garlanda; Rozzano, Italy 143 P1.11.007 - Interaction of Bordetella pertussis filamentous hemagglutinin with human TLR2: identification of the TLR2-binding domain Hossein Asgarian-Omran, A. Amirzargar, S. Zeerleder, M. Mahdavi, G. van Mierlo, S. Solati, M. Jeddi-Tehrani, H. Rabbani, L. Aarden, F. Shokri; Tehran, Iran, Islamic Republic of 144 P1.11.008 - S100A8 and S100A9 promote hyporesponsiveness of phagocytes in polytrauma and burn patients Judith Austermann, S. Fassl, B. Petersen, E. Faist, S. Zedler, T. Vogl, J. Roth; Muenster, Germany 145 P1.11.009 - Extended anti-cancer immunity by liposomes coencapsulating nucleic acid TLR-ligands and antigen Banu Bayyurt, G. Gucluler, D. Bayik, E. Alpdundar, S. Yildiz, B.H. Horuluoglu, M. Ozcan, M. Gursel, I. Gursel; Ankara, Turkey 146 P1.11.010 - R848, a Toll-like receptor 7/8 agonist, a potential therapy for allergic rhinitis patients Ghada Boghdadi, N. Hammad, A. Amer, S. Sammour, S. Sorour; Zagazig, Egypt 147 P1.11.011 - TLR4-induced activation of human monocyte cell line U937 by sickle patient’s mmLDL. Possible experimental model for atherosclerosis initial phase Beatriz E. Brito, M.A. Duarte, E.L. Romano, M.E. Marquez, L. Baute, O. Perez-Bandez, N. Torrez; Caracas, Venezuela, Bolivarian Republic of 148 P1.11.012 - Fungal stimulated inflammatory response of gestation associated tissues Aled H. Bryant, R.H. Jones, N. Melo, S.E. Owens, L.B. Davies, G. Morgan, I.M. Sheldon, C.A. Thornton; Swansea, United Kingdom 149 P1.11.013 - Triggering receptor expressed on myeloid cells (TREM)-1 and -2 in bronchoalveolar lavage fluid in pulmonary sarcoidosis Milan Buc, M. Suchankova, M. Bucova, E. Tibenska, E. Tedlova, J. Demian, I. Majer, H. Novosadova, M. Tedla, E. Paulovicova; Bratislava, Slovakia 150 P1.11.014 - Increased CD4 T cell survival during in vivo OVA-LPS presentation is partly inhibited by indomethacin and recovered by PGE2 analog Julia C. Campopiano, J.F. Jacysyn, M. Zenteno, T.B. da Costa, K.R. Bortoluci, G.P. Amarante-Mendes; São Paulo, Brazil 151 P1.11.015 - Optimal Immune Response Is Mediated by CD8-IFN Gamma Production and Macrophages-iNOS Expression in trigeminal ganglia, after Interactions of Toll Like Receptors in Herpes Simplex Virus -1 (HSV-1) Infection G.P. Zolini, G.K. Lima, N. Lucinda, M.G.A. Silva, S.R. Béla, L.R.V. Antonelli, N.L. Pessoa, B.C. Pizziolo, E.G. Kroon, Marco A. Campos; Belo Horizonte, Brazil 152 P1.11.016 - Monocyte-produced TLR2 and TLR4 but not prolactin are involved in both, late-onset autoimmune diabetes and type 2 diabetes development Pavlina Cejkova, V. Slukova, I. Nemeckova, J. Broz, M. Andel, M. Cerna; Prague 2, Czech Republic 90 Posters - August 23 153 P1.11.017 - Roles of an innate immune regulator TBK1-Associated Protein in Endolysosomes (TAPE) in the RIG-I-like receptor and DNA sensor pathways Kuan-Ru Chen, C. Chang, C. Huang, C. Lin, W. Lin, Y. Lo, C. Yang, A. Shiau, T. Tan, P. Ling; Tainan, Taiwan 154 P1.11.018 - Immunostimulatory activities of CpG-oligodeoxynucleotides in zebrafish D. Yeh, Y. Liu, Tsung-Hsien Chuang; Miaoli County, Taiwan 155 P1.11.019 - New molecular tools to investigate LPS recognition Roberto Cighetti, V. Calabrese, G. Damore, M. Piazza, F. Peri; Milano, Italy 156 P1.11.020 - The Q705K genetic variant in NLRP3 leads to inflammasome hyperactivation and contributes to invasive aspergillosis after stem cell transplantation Cristina Cunha, C. Galosi, M. Puccetti, F. Aversa, L. Romani, A. Carvalho; Perugia, Italy 157 P1.11.021 - The Role of TLRs in the Dogs Immunized with the Gentamicin-attenuated L. infantum Compared with Dogs Infected with Wild-type Parasites Maryam Davarpanah; Kerman, Iran, Islamic Republic of 158 P1.11.022 - Unbalanced cytokine production in inducible nitric oxide synthase-deficient neonate mice upon in vitro stimulation with TLR agonists Cyro A. de Brito, B.S. Shida, N.Z. Pereira, A.J.S. Duarte, M.N. Sato; Sao Paulo, Brazil 159 P1.11.023 - Myeloid-related protein (Mrp)-8/14 contributes to protective immunity in sepsis caused by Burkholderia pseudomallei and elevated levels correlate with poor outcome Hanna K. de Jong, T.A.F. Weehuijzen, A. Achouiti, L.M. Kager, G.C.K.W. Koh, J. Roth, T. Vogl, T. van der Poll, W.J. Wiersinga; Amsterdam, Netherlands 160 P1.11.024 - Response of human monocyte-derived dendritic cells to the combined effect of TLR3 and TLR7 agonists Tanja Dzopalic, A. Dragicevic, B. Bozic, I. Rajkovic, M. Colic; Nis, Serbia 161 P1.11.025 - Association of TLR4-D299G polymorphism with inflammation and overexpression of TLR4-CD14 in obese mexican patients C.O. De Loera-Rodriguez, J.E. Segura-Ortega, V. Delgado-Rizo, A. Alvarado-Navarro, Mary Fafutis-Morris; Guadalajara, Mexico 162 P1.11.026 - Potential role of tlr ligand in aethiopathogenesis of Tunisian endemic pemphigus foliaceus O. Abida, Raouia Fakhfakh, D. Bouzid, S. Krichen-Makni, N. Kharrat, A. Masmoudi, M. Abdelmoula, M. Ben Ayed, H. Turki, T. Sellami-Boudawara; Sfax, Tunisia 163 P1.11.027 - The C-type lectin receptors on dendritic cells participate in the recognition and modulatory effect of high molecular weight components of Ascaris suum extract B.C. Favoretto, P.A. Ranéia, J.A. Portes-Junior, J.F. Jacysyn, Eliana L. Faquim-Mauro; São Paulo, Brazil 164 P1.11.028 - Isolation and characterization of N-linked glycan structures from high molecular weight components of Ascaris suum extract Bruna C. Favoretto, J.F. Jacysyn, A. Casabuono, A.S. Couto, E.L. Faquim-Mauro; São Paulo, Brazil 165 P1.11.029 - Involvement of the nucleic acid recognizing Toll-like receptors TLR7 and TLR9 in the pathogenesis of erosive arthritis Anita Fischer, C. Böhm, S. Herman, V. Saferding, E. Goncalves-Alves, M. Koenders, W. van den Berg, G. Steiner; Vienna, Austria 166 P1.11.030 - Training modifies the innate immune response both in the airways and in blood in horses Linda Frellstedt, P. Gosset, C. Desmet, D. Pirottin, F. Bureau, I. Waldschmidt, M. Dupuis-Tricaud, P. Lekeux, T. Art; Liege, Belgium 167 P1.11.031 - The novel TLR7 agonist GS-9620 induces a diverse set of interferon stimulated genes Christian Frey, A. Palazzo, J. Hesselgesser, T. Cihlar, S. Pflanz; Foster City, United States 168 P1.11.032 - NOD-like receptor activation stimulates osteoclasts Sandra Y. Fukada Alves, M.R.F. Holanda, T.M. Taira, F.Q. Cunha; Ribeirão Preto, Brazil 169 P1.11.033 - Collapse of TLR7/TLR9 balance leads genetical background dependent phenotypes Ryutaro Fukui, K. Miyake; Minato-ku, Tokyo, Japan 170 P1.11.034 - Toll-like receptors 2, 4 and CD14 gene polymorphisms in Tunisian kidney transplantation Yousr Gorgi, H. Krichen, Y. Mechiri, I. Sfar, T. Dhaouadi, R. Bardi, M. Bacha, R. Kheder, E. Abderrahim, T. Ben Abdallah; Tunis, Tunisia 171 P1.11.035 - Polymorphisms of Toll-like receptor 4 and CD14 genes in systemic lupus erythematosus and rheumatoid arthritis Yousr Gorgi, T. Dhaouadi, Y. Haouami, I. Sfar, L. Abdelmoula, S. Turki, L. Ben Hassine, R. Zouari, N. Khalfallah, T. Ben Abdallah; Tunis, Tunisia 91 Posters - August 23 172 P1.11.036 - D type CpG oligonucleotide loaded EG-7 exosomes act as strong vaccine adjuvant and anti-cancer agent Gozde Gucluler, T. Kahraman, D. Bayik, A. Gursel, M. Gursel, I. Gursel; Ankara, Turkey 173 P1.11.037 - CpG Oligodeoxynucleotide/cationic peptide nanorings as immunotherapeutic agents Bilgi Gungor, F.C. Ya cı, I. Gursel, M. Gursel; Ankara, Turkey 174 P1.11.038 - Mechanisms of MyD88- and TRIF-dependent downregulation of the glucocorticoid induced leucine zipper (GILZ) in macrophages - mRNA destabilization vs. microRNAs Nina Hachenthal, T. Stadter, P. Leidinger, F. Grässer, E. Meese, S. Bruscoli, C. Riccardi, A.K. Kiemer, J. Hoppstädter; Saarbruecken, Germany 175 P1.11.039 - Expression Analysis of Molecular Markers of Inflammation in Human Monocytic THP-1 cells Cultured with Single Walled Carbon Nanotubes Functionalized with Polyethylene Glycol (PEG-SWNT) Alireza Haghparast, M. Heidari Kharaji, M. Moghaddam Matin, A. Ahmadpour; Mashhad, Iran, Islamic Republic of 176 P1.11.040 - Characterization of antibody responses to M13 phage vaccine: MyD88-dependent and T-cell independent IgG subclass responses Shuhei Hashiguchi, M. Toyonaga, Y. Shoji, T. Gotanda, K. Sugimura; Kagoshima, Japan 177 P1.11.041 - Card9 is essential for the CEACAM3 mediated Moraxella catarrhalis induced NF-kappaB activation in human granulocytes A. Heinrich, Kerstin A. Heyl, M.M. Müller, S. Bachmann, H. Slevogt; Jena, Germany 178 P1.11.042 - Immune complexes isolated from malaria patients activate TLR9 and promote caspase-1 activation Isabella Hirako, C. Gallego, H. Gravina, M. Ataíde, D. Pereira, B. Diamond, L.R. Antonelli, D.T. Golenbock, R.T. Gazzinelli; Belo Horizonte, Brazil 179 P1.11.043 - Identification of novel innate pattern recognition receptors for mycobacterium tuberculosis Ei’ichi Iizasa, T. Myamoto, T. Uematsu, T. Ishikawa, S. Yamasaki, G. Matsuzaki, H. Yoshida, H. Hara; Saga, Japan 180 P1.11.044 - Regulation of autoimmune responses by the innate immune system in response to bacterial infections Jincy M. Issac, Y. Mohammed, H.T. Nasser, M. Rabah, M.J. Fernandez-Cabezudo, W. Conca, B.K. al-Ramadi; Al Ain, United Arab Emirates 181 P1.11.045 - The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection Sebastien Jaillon, F. Moalli, B. Ragnarsdottir, E. Bonavita, M. Nebuloni, A. Markotic, A. Montanelli, C. Svanborg, C. Garlanda, A. Mantovani; Rozzano, Italy 182 P1.11.046 - ER stress sensitizes TLR signaling and desensitizes LPS tolerance through IRE1 -mediated activation of GSK-3β S. Kim, Yeonsoo Joe, J. Shin, S. Ryter, H. Chung; Ulsan, Korea, Republic of 183 P1.11.047 - Investigation of kinase and inflammatory pathway modulation by I2PP2A inhibition in Prostate Cancer Progression Carol Johnson, F.J. Giles, F.J. Sullivan, M. Vitek, S.A. Glynn; Galway, Ireland 184 P1.11.048 - Toll-like receptor (TLR)-4 and Hepatitis C Virus (HCV): a systematic review Nazanin A. Kazemi Sefat, G.E. Kazemi Sefat, S. Talebi; Kerman, Iran, Islamic Republic of 185 P1.11.049 - TLR-signaling induces Type I interferon responses in microglia and astrocytes and regulates leukocyte infiltration to the CNS Reza M.H. Khorooshi, T. Holm, C. Tue Berg, R. Truong Dieu, D. Dræby, S. Lienenklaus, T. Owens; Odense, Denmark 186 P1.11.050 - A reticulon family protein Nogo is an active component of TLR-triggered innate immune responses in macrophages Toshifumi Kimura, M. Inui, T. Takai; Sendai, Japan 187 P1.11.051 - Analysis of the B cell responsiveness to the TLR9 agonist CPG in malaria semi-immune versus malaria naïve individuals Younoussou Kone, K. Kassoum, A. Ongoiba, D. Safiatou N, D. Didier, M. Jacqueline, S. Portugal, P. Susan K., D. Ogobara K., C. Peter D.; Bamako, Mali 188 P1.11.052 - TLR9-mediated synergistic T-bet expression and its implication for antibody production Dorottya Kovesdi, G. Sarmay; Budapest, Hungary 189 P1.11.053 - RIG-I dependent cross-priming of CD8+ T-cells M. Bscheider, Diana Kreppel, J. Fischer, T. Franz, U. Kalinke, J. Ruland, C. Peschel, T. Haas, H. Poeck; Munich, Germany 190 P1.11.054 - Some features of cellular immunity in patients with chronic spontaneous urticaria inducing reactivation of chronic EBV infection E.A. Sorokina, N.K. Akhmatova, E.A. Akhmatov, Olga V. Lebedinskaya; Perm, Russian Federation 92 Posters - August 23 191 P1.11.055 - Influence of the PAMPs of opportunistic microorganisms on the TLRs expression N.P. Utkina, E.A. Akhmatov, E.A. Ilinykh, E.V. Sorokina, E.A. Lebedinskaya, E.C. Marakasova, Olga V. Lebedinskaya, E.A. Kurbatova, N.K. Akhmatova; Perm, Russian Federation 192 P1.11.056 - Myeloid differentiation protein 2 as the target of curcumin analog in the inhibition of endotoxin LPS-induced TLR-4 activity Guang Liang, Y. Wang, L. Jiang, X. Shan; Wenzhou, China 193 P1.11.057 - Immunomodulatory effects of P-MAPA on TLR2, ROS and nitric oxide of blood mononuclear cells from canine with visceral leishmaniasis Valéria M. Lima, L.M. Melo, L.d. Sanches, J. Perosso, K.L.O. Silva; Araçatuba, Brazil 194 P1.11.058 - Dendritic cells differentiated using GM-CSF/IL-4 or FLT3L respond differently to TLR ligand maturation signals, affecting the quality of the primed CD8+ T-cell response Anna Lissina, O. Briceno, E. Martinuzzi, E. Gostick, D.A. Price, R. Mallone, V. Appay; Paris, France 195 P1.11.059 - Synergy in cytokine production induced by combinatorial TLR activation Qian Liu, J. Ding; Singapore, Singapore 196 P1.11.060 - The cationic lipid diC14-amidine and bacterial lipopolysaccharides both activate Toll-like receptor 4 pathways via different binding regions of TLR4 Caroline Lonez, K. Irvine, M. Gangloff, B. Caroyez, J. Ruysschaert, M. Vandenbranden, C.E. Bryant; Cambridge, United Kingdom 197 P1.11.061 - Dectin-1 induces efficient T cell immunity and prominent expansion of CD8+ IL-17+ cells in a pulmonary model of fungal infection Flávio V. Loures, V.L.G. Calich; São Paulo, Brazil 198 P1.11.062 - MSK1 and 2 inhibit LPS induced prostaglandin production via an IL-10 feedback loop Kirsty F. MacKenzie, M.M.W. van den Bosch, S. Naqvi, S.E. Elcombe, V.A. McGuire, A.D. Reith, P.J. Blackshear, J.L.E. Dean, S.C. Arthur; Dundee, United Kingdom 199 P1.11.063 - Functions of endogenous TLR4 ligands Yoshiro Maru; Tokyo, Japan 200 P1.11.064 - Similarities and differences of innate immune responses elicited by smooth and rough LPS Roberta Marzi, I. Zanoni, A. Broggi, R. Ostuni, M. Caccia, M. Collini, A. Venkatesh, R. Spreafico, G. Capuano, F. Granucci; Milano, Italy 201 P1.11.065 - Multi-step regulation of STAT1 phosphorylation in response to double-stranded RNA Tomoh Matsumiya, J. Dempoya, F. Xing, R. Hayakari, H. Yoshida, T. Imaizumi; Hirosaki, Japan 202 P1.11.066 - Hepatic TDO2-derived L-kynurenine controls acute inflammatory responses by engaging the Aryl hydrocarbon Receptor Giada Mondanelli, M. Gargaro, A. Bessede, D. Matino, M. Pallotta, C. Vacca, H. Funakoshi, U. Grohmann, P. Puccetti, F. Fallarino; Perugia, Italy 203 P1.11.067 - Expression of TLR2, 3, 9, MYD88 and TRIF in Kawasaki patients before and after IVIG therapy Hamid R. Mortazavi, S. Aleyasin, M. Babaei, R. Amin, M.H. Karimi; Shiraz, Iran, Islamic Republic of 204 P1.11.068 - CpG ODN ligation of TLR-9 stimulates IFN- and antinuclear antibody production in SLE patients Sahar Morteza Gholi, Z. Babaloo, P. Rahimzadeh, M. Ghayedi, H. Namdari, F. Gharibdoost, M. Taghadosi, E. Salehi; Tabriz, Iran, Islamic Republic of 205 P1.11.069 - Genetic polymorphisms in host innate immune sensor genes and the risk of Nasopharyngeal carcinoma in North Africa Khalid Moumad, J. Lascorz, M. Bevier, M. Khyatti, M. Ennaji, S. Huhn, S. Lu, L. Chouchane, M. Corbex, A. Försti; Heidelberg, Germany 206 P1.11.070 - The self-perpetuating mechanism of antiphospholipid antibody production depends on TLR7 activation and endosomal superoxide generation Nadine Müller-Calleja, P. Stein, A. Canisius, C. Orning, M. Radsak, K.J. Lackner; Mainz, Germany 207 P1.11.071 - Dual regulation of osteopontin production by TLR stimulation in dendritic cells Tiziana Musso, S. Scutera, V. Salvi, S. Rossi, M. Alessandria, D. Bosisio, S. Sozzani; Torino, Italy 208 P1.11.072 - Toll-like receptor genetic polymorphism influences susceptibility and severity to tuberculosis in the Indian Population Neelam Najmi, G. Kaur, S. Sharma, R. Mehra, N. Mehra; New Delhi, India 209 P1.11.073 - Association study between Toll-like receptor 4 single-nucleotide polymorphisms and bipolar disorder José Oliveira, W. Boukouaci, M. Bennabi, A. Dargél, B. Etain, C. Henry, F. Bellivier, J. Kahn, M. Leboyer, R. Tamouza; Créteil, France 93 Posters - August 23 210 P1.11.074 - Schistosome-activated B cell surface toll-like receptor-4 expression correlates with CD23 and IgM expression Daniel O. Onguru, A.V.O. Ofulla, L. Ganley-Leal, P.N. Mwinzi; Kisumu, Kenya 211 P1.11.075 - Toll-like receptor -2, -4 and -9 genetic variants in Mexican patients with amoebic liver abscess Oswaldo Partida-Rodriguez, E.G. Hernandez, C. Maldonado, U. Magaña, O. Valenzuela, M.E. Nieves-Ramirez, E. Gonzalez, A. Valadez, P. Moran, C. Ximenez; Mexico City, Mexico 212 P1.11.076 - The role of Damage Associated Molecular Patterns (DAMPs) in the genetic susceptibility towards cigarette smoke induced neutrophilic airway inflammation Simon D. Pouwels, I.H. Heijink, L.E. Den Boef, M.H. Boezen, M.C. Nawijn, A.J.M. van Oosterhout; Groningen, Netherlands 213 P1.11.077 - Friends of our enemy are our enemy: Bacteria modulate cancerous behavior of prostate cancer cell lines via TLR signaling Simin Rezania, N. Rashidi, O. Zarei, A. Kalantari, A. Zarnani; Graz, Austria 214 P1.11.078 - Using recombinant lactococci constructs as a molecular tool to dissect the immunomodulating capacity of surface piliation in Lactobacillus rhamnosus GG I. von Ossowski, T.E. Pietilä, Johanna Rintahaka, E. Nummenmaa, V. Mäkinen, J. Reunanen, R. Satokari, W.M. de Vos, I. Palva, A. Palva; Helsinki, Finland 215 P1.11.079 - LPR mice with TIR8 deficiency are prone to develop B-cell lymphomas Federica Riva, M. Ponzoni, S. Bertilaccio, N. Polentarutti, A. Anselmo, A. Innocenzi, F. Caligaris-Cappio, A. Mantovani, M. Muzio, C. Garlanda; Milano, Italy 216 P1.11.080 - Vav proteins mediate Syk-coupled C-type lectin receptor-induced innate immunity Susanne Roth, H. Bergmann, K. Neumann, V. Laux, C. Prazeres da Costa, V.L. Tybulewicz, X. Bustelo, J. Ruland; Munich, Germany 217 P1.11.081 - Cigarette smoke modulates the oral epithelial cell innate immunity Mahmoud Rouabhia, A. Semlali, M. Alanazi, J. Chakir; Quebec, Canada 218 P1.11.082 - The role of NF-κB oscillation in inflammatory responses to Salmonella infection Jiro Sakai, J. Wright, C.E. Bryant; Cambridge, United Kingdom 219 P1.11.083 - Characterization of SSc5D, a molecule of the Scavenger Receptor Cysteine-Rich Superfamily, as an innate immune receptor Rita Santos, C. Bessa-Pereira, C.M. Gonçalves, A.M. Carmo; Porto, Portugal 220 P1.11.084 - Essential role of IRF3 in microbiota-contributed Tslp induction and protection against intestinal inflammation Hana Sarashina, H. Negishi, S. Miki, T. Taniguchi; Tokyo, Japan 221 P1.11.085 - Investigating the deregulation of Toll-like receptors, pro-inflammatory cytokines and cationic peptides (Human Beta Defensins) in normal and colon cancer tissue Abdelhabib Semlali, A. AL Amri, H. Saeed, A. Aljebreen, O. Alharbi, M. Almadi, N. Ali Azzam, N. Reddy.P, M. Arafah, M. Rouabhia, M. Al-Anazi; Riyadh, Saudi Arabia 222 P1.11.086 - Investigating the expression of Toll-like receptor-2,4 and 6 in normal and ovarian cancer tissue Y. Al-Anazi1, M. Al-Anazi, M. Al-Mutairi, M. Adar, M. Arafah, A. Warsy, S. Al-Daihan, M. Rouabhia, Abdelhabib Semlali; Riyadh, Saudi Arabia 223 P1.11.087 - Proteolytic cleavage of human Toll-like receptor 3 by lysosomal proteases is required for receptor activation Jin-Won Seo, E. Yang, I. Choi; Seoul, Korea, Republic of 224 P1.11.088 - TLR7 signalling in macrophages activates IRF3 and is dependent on the adaptor TRAM Enda Shevlin, S.M. Miggin; Kildare, Ireland 225 P1.11.089 - Inverse Correlation between Histamine Receptor Expression and Toll-like Receptor Activation in Peripheral Blood Mononuclear Cells from Inflammatory Bowel Disease Patients Sylwia Smolinska, P. Konieczna, T. Lukienczuk, R. Olewinski, G. Nowak, M. Jutel, L. O’Mahony; Wroclaw, Poland 226 P1.11.090 - Plasmacytoid dendritic cells play a key role in tumor progression in LPS-stimulated lung tumor-bearing mice Rosalinda Sorrentino; Fisciano, Italy 227 P1.11.091 - Pam3CSK4, a TLR2 agonist, induces in vitro osteoclastogenesis RANKL-independently and resorbs calvarial and alveolar bone in vivo Keiko Suzuki, T. Arimoto, T. Morohashi, N. Sakai, A. Karakawa, H. Shinoda, S. Yamada; Tokyo, Japan 228 P1.11.092 - TLR3 recognizes single-stranded RNA with incomplete stem structures Megumi Tatematsu, F. Nishikawa, T. Seya, M. Matsumoto; Sapporo, Japan 94 Posters - August 23 229 P1.11.093 - Studies on the full-length human NOD-like receptor family CARD domain containing 5 (NLRC5) protein J.A. Mótyán, A. Varga, D. Varga, K. Matúz, S. Benk , József Tőzsér; Debrecen, Hungary 230 P1.11.094 - Activation of innate immunity through the CARD9 pathway is involved in severe influenza pneumonia Takayuki Uematsu, E. Iizasa, N. Kobayashi, H. Yoshida, H. Hara; Kitamoto City, Saitama, Japan 231 P1.11.095 - TLR3 as an Exacerbating Factor for Radiation-Induced Gastrointestinal Syndrome Satoshi Uematsu, N. Takemura, S. Akira; Minato-ku, Tokyo, Japan 232 P1.11.096 - AGE-BSA induces self- and cross-tolerance in the monocytic Mono Mac 6 cell line Florian Uhle, I. Magel, M.A. Weigand; Giessen, Germany 233 P1.11.097 - Role of the TLR7, 8 and 9 polymorphisms in the susceptibility to HIV-1 infection in southern Brazilian patients Jacqueline Valverde, B. dos Santos, V. Mattevi, R. Lazzaretti, E. Sprinz, R. Kuhmmer, J. Chies; Porto Alegre, Brazil 234 P1.11.098 - TLR9 enhances bacterial clearance and limits lung consolidation in murine MRSA pneumonia Anne J. van der Meer, A. Achouiti, S.S. Zeerleder, A.F. de Vos, T. van der Poll; Amsterdam, Netherlands 235 P1.11.099 - A TLR9/TRIF pathway induces tolerance via TGF-β and tryptophan catabolism in plasmacytoid dendritic cells Gloria Castellano Gonzalez, F. Fallarino, U. Grohmann, P. Puccetti; Perugia, Italy 236 P1.11.100 - Mannan-binding lectin inhibits Candida albicans-induced cellular responses of human THP-1 cells through toll-like receptor 2 and toll-like receptor 4 Mingyong Wang; Xinxiang, China 237 P1.11.101 - Rab7 GTPase negatively regulate inflammatory cytokine and type I interferon expression in LPS-stimulated macrophages via GTP-binding dependent manner Yuzhen Wang, J. Xie, X. Yun, W. Zhang, S. Dong, Y. Zheng, Y. Wan, J. Liu, P. Gong, S. Zhao, H. Kang; Hohhot, China 238 P1.11.102 - Both Toll-like receptor-2 and -4 contribute to signalling of Burkholderia pseudomallei’s lipopolysaccharide W. Joost Wiersinga, T. van der Vaart, L. Kager, S. Ngugi, J. Prior, T. van der Poll; Amsterdam, Netherlands 239 P1.11.103 - Toll-like receptor-5 contributes to protective immunity in Gram-negative sepsis caused by Burkholderia pseudomallei, independent of flagella presence W. Joost Wiersinga, M. van Lieshout, J. Roelofs, T. Schuijt, T. van der Poll; Amsterdam, Netherlands 240 P1.11.104 - A comparison of Pattern Recognition Receptor requirement for human and horse strains of Streptococcus pneumoniae Hannah Williams, G. Paterson, C. Bryant; Cambridge, United Kingdom 241 P1.11.105 - Molecular mechanisms regulating the synergism between IL-32γ and NOD ligands for the induction of adhesion molecules, cytokines and chemokines of eosinophils in allergic inflammation C K. Wong, J. Dong, C.W.K. Lam; Shatin, NT, Hong Kong 242 P1.11.106 - Up-regualtion of HuR was critical for TLR9 signaling induced repression of tumor suppressor miR-7 in human lung cancer cells Y. Li, Z. Liao, S. Zhu, Y. Hu, C. Chen, J. Luo, Lin Xu; Zunyi, China 243 P1.11.107 - Choreography and molecular strategy of dendritic cell-mediated NK cell activation in lipopolysaccharide-mediated inflammatory conditions Ivan Zanoni, R. Spreafico, C. Bodio, M. Di Gioia, C. Cigni, A. Broggi, T. Gorletta, M.P. Colombo, N. Garbi, F. Granucci; Milan, Italy 244 P1.11.108 - Lithium attenuates IFN-β production and antiviral response via inhibition of TBK1/IKK-ε kinase activity Wei Zhao, L. Wang, L. Zhang, C. Gao; Jinan, China 245 P1.11.109 - Mutated class II transactivator activates the IL-33-upregulated Th2 differentiation via the Nod2-involved NLR signal pathway Z.Q. Yang, P. Gu, Z.Q. Li, Y. Zhou, L.M. Lu, G- Y. Zhou; Shanghai, China 246 P1.11.110 - Involvement of toll like receptor 2/3/4 and 9 polymorphisms in the occurrence of cervical cancer in Tunisian women Sabrina ZIDI, H. Verdi, Y. Yilmaz-Yalcin, Y. Suer, E. Gazouani, A. Mezlini, F. Atac, B. Yacoubli-Loueslati; Manar I tunis, Tunisia 95 Posters - August 23 P1.13 FC AND FC-LIKE RECEPTORS Session Time: Friday, August 23, 13:20 -15:00 247 P1.13.01 - CD16 aggregation induced by therapeutic antibody-opsonised targets impairs cytotoxic responses in human NK cells Cristina Capuano, M. Romanelli, C. Pighi, R. Molfetta, R. Paolini, A. Santoni, R. Galandrini; Rome, Italy 248 P1.13.02 - Streptococcus pneumoniae triggers platelet activation and platelet-leukocyte complex formation in a strain dependent and Toll-like receptor 2 independent manner Sacha F. de Stoppelaar, M.C.L. Schaap, T. van der Poll, R. Nieuwland, C. van ‘t Veer; Amsterdam, Netherlands 249 P1.13.03 - Association of FCRL3 genotypes with susceptibility of Iranian patients to rheumatoid arthritis Hossein Golmoghaddam, Z. Amirghofran, E. Aflaki, E. Kamali-Sarvestani, M. Shabani, Z. Esmaeilbeig, M. Rajabi; Shiraz, Iran, Islamic Republic of 250 P1.13.04 - Fca/mR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock Shin-ichiro Honda, K. Satoh, Y. Matsuoka, T. Matsushita, M. Fujimoto, A. Shibuya; Tsukuba city, Japan 251 P1.13.05 - Association of FCγRIIA(CD32) polymorphism with susceptibility to brucellosis Zahra Hosseini Khah, A. Rafiei; Sari, Iran, Islamic Republic of 252 P1.13.06 - The role of Prohibitin (PHB) in the initial reaction of the IgE Fc receptor signal from lipid raft Takahiro Ichii, T. Aradate, Y. Mitsuhashi, M. Hachiya, N. Tani, Y. Yamanoi, M. Kanamori, A. Muraguchi, T. Katagiri; Toyama city, Japan 253 P1.13.07 - Engagement of the IgM Fc receptor (FcµR) with its ligand occurs in cis rather than trans K. Honjo, Y. Kubagawa, J.F. Kearney, Hiromi Kubagawa; Birmingham, United States 254 P1.13.08 - Selective immunotherapy of lupus prone mice by biologically active peptides and simultaneous engagement of BCR and inhibitory B-cell receptors Nikolina M. Mihaylova, K. Nikolova-Ganeva, M. Nikolova, T. Todorov, A. Tchorbanov; Sofia, Bulgaria 255 P1.13.09 - FcγRIIa (CD32) polymorphism and anti-malarial IgG subclass pattern among Fulani and sympatric ethnic groups living in eastern Sudan Amre Nasr, N.C. Iriemenam, H.A. Giha, H.A. Balogun, R.F. Anders, M. Troye-Blomberg, G. ElGhazali, K. Berzins; Khartoum, Sudan 256 P1.13.10 - Greater number of activated T cells and enlarged germinal centers in the spleen of bovine FcRn transgenic mice in the background of the enhanced immune response Zita Schneider, A. Végh, J. Cervenak, P. Balogh, I. Kacskovics; Budapest, Hungary 257 P1.13.11 - Intravenous immunoglobulin treatment suppresses dendritic cell function in humans by stimulation of the IL-33-Th2 pathway Rogier van Gent, A.S.W. Tjon, H. Jadaar, M. van Hagen, L.J.W. van der Laan, P.A.W. te Boekhorst, H.J. Metselaar, J. Kwekkeboom; Rotterdam, Netherlands 258 P1.13.12 - FcgammaRIIA and FcgammaRIIIB polymorphisms in Brazilian systemic lupus erythematosus patients and associations with clinical manifestations Cleni Mara Marzocchi-Machado, J.E.T. Toller-Kawahisa, J.A.T. Pancoto, C.T. Mendes-Junior, E.Z. Martinez, E.A. Donadi, P. LouzadaJúnior, J.E.C. Del Lama; Ribeirão Preto, Brazil P1.17 ALLERGIC MEDIATORS Session Time: Friday, August 23, 13:20 -15:00 259 P1.17.01 - Parvalbumin: as a fish-allergen Syed H. Arif; Jazan, Saudi Arabia 260 P1.17.02 - Clock genes and eosinophil-specific mediators are expressed in a circadian manner in human eosinophils Anja Baumann, O. Froy, S.C. Bischoff, A. Lorentz; Stuttgart, Germany 261 P1.17.04 - Regulation of allergen-specific IgA and IL-17 responses by intestinal epithelial cell IKKβ reshapes allergic inflammation at distant sites A. Bonnegarde-Bernard, J. Jee, M.J. Fial, F. Aeffner, E. Cormet-Boyaka, I.C. Davis, M. Lin, D. Tomé, M. Karin, Prosper N. Boyaka; Columbus, United States 262 P1.17.05 - Regulation of human skin mast cell histamine release by PDE inhibitors Nahid Eskandari, R. Bastan, P. Peachell; Isfahan, Iran, Islamic Republic of 263 P1.17.06 - Interferon-α antagonizes IL-3-mediated immunoregulatory functions of human basophils Björn Hagmann, A. Odermatt, A. Eggel, C.A. Dahinden, M. Fux; Bern, Switzerland 96 Posters - August 23 264 P1.17.07 - Serum IgE and Eosinophil level in patients Infected with giardiasis Morteza Hosseinzadeh, A. Khosravi, E. Sabbagh, K. Sayemiri; Tehran, Iran, Islamic Republic of 265 P1.17.08 - Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation Fumitaka Kamachi, M. Hara, N. Harada, Y. Katsura, Y. Kojima, K. Izawa, C. Nishiyama, K. Okumura, H. Akiba; Tokyo, Japan 266 P1.17.09 - Role of IL-6 in the development of dendritic cell-induced allergic inflammation Yen-Lin Lin, J. Wang; Tainan, Taiwan 267 P1.17.10 - Role of the CC-chemokine receptor CCR9 as a modulator of the inflammatory process during allergic airway inflammation Cynthia P. Lopez-Pacheco, G. Du Pont, G. Soldevila, E.A. García-Zepeda; Mexico, Mexico 268 P1.17.11 - Multiplex immunoassay for allergens using oligonucleotide tethering Robert S. Matson; Irvine, United States 269 P1.17.12 - Microfibrillar-associated protein 4 deficiency attenuates experimental allergic airway inflammation Bartosz Pilecki, A.T. Holm, A. Schlosser, H. Wulf-Johansson, J.B. Møller, J. Vestbo, C. Stevenson, U. Holmskov, G.L. Sorensen; Odense, Denmark 270 P1.17.13 - S1P/SphK signalling in mast cells: relevance to airway inflammation, asthma and anaphylaxis Peter N. Pushparaj, J. Manikandan, S.D. Kumar, L.A. Damiati, K. Gauthaman, M.H. Al-Qahtani; Jeddah, Saudi Arabia 271 P1.17.14 - Identification of a novel quantitative trait locus and candidate genes for airway hyperresponsiveness C. Kanagaratham, R. Marino, P. Camateros, R. Sladek, S. Vidal, Danuta Radzioch; Montreal, Canada 272 P1.17.15 - Circulating human basophils lack the features of professional antigen presenting cells Meenu Sharma, P. Hegde, V. Aimanianda, R. Beau, H. Sénéchal, P. Poncet, S.V. Kaveri, J. Bayry; Paris, France 273 P1.17.16 - Intratracheally administration Asian sand dust activates NF-kappaB in immune cells Yuan Song, T. Ichinose, T. Kanazawa, Y. Yoshida; Kitakyushu, Japan 274 P1.17.17 - Receptor for advanced glycation end products (RAGE) - a central mediator of allergic sensitization Md. A. Ullah, Z. Loh, W.J. Gan, V. Zhang, J.M. Hughes, C.L. Armour, S. Phipps, M.B. Sukkar; Sydney, Australia P2.01 LEUKOCYTE SIGNALLING Session Time: Friday, August 23, 13:20 -15:00 275 P2.01.01 - Hydrophobic amino acid cluster in the cytoplasmic tail of interleukin-2 receptor β chain acts as a sorting signal for lysosome Yuji Amano, K. Kojima, K. Yoshino, T. Takeshita; Matsumoto, Nagano, Japan 276 P2.01.02 - Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway F.M. Juliana, H. Nara, T. Onoda, M. Rahman, A. Araki, L. Jin, H. Fujii, N. Tanaka, T. Hoshino, Hironobu Asao; Yamagata, Japan 277 P2.01.03 - Notch receptors and ligands expression in human T cell development Luciana Bento-de-Souza, J. R. Victor, J.B. Oliveira Filho, A.C. Rangel-Santos, E. Pereira-Costa, L.C. Bento-de-Souza, M. Arrais-Santos, E. Raniero-Fernandes, M.I. Seixas-Duarte, A.J. da Silva Duarte; Sao Paulo, Brazil 278 P2.01.05 - Site-wide quantitative phosphoproteomics reveal non-redundant pathways regulated by IL-7 and IL-15 in memory CD8+ T cells Marlene J. Carrasco-Alfonso, S. Ficarro, Y. Zhang, W. Jiang, J. Marto, J. Luckey; Boston, United States 279 P2.01.06 - Quantifying differential T cell responses using tuneable material surfaces Susan N. Christo, B.R. Coad, G.T. Sarvestani, H.J. Griesser, K. Vasilev, R. Nordon, C.K. Fraser, M.P. Brown, K.R. Diener, J.D. Hayball; Adelaide, Australia 280 P2.01.07 - Levodopa-induced neutropenia in Parkinson’s disease Christian Cordano, B. Parodi, A. Uccelli, A. Schenone, L. Schembri, F. Marino, M. Cosentino; Genova, Italy 281 P2.01.08 - Correlation between low tyrosine phosphatase activity of inhibitory SHP-1 and high proliferation in chronic lymphocytic leukemia (CLL) B-cells P. Delfani, Z. El-Schich, A. Rosén, Anette Gjörloff Wingren; Malmö, Sweden 282 P2.01.09 - Functional regions in the Ankyrin Repeat Domain 54/ Liar protein which regulate nucleocytoplasmic shuttling of Bruton’s Tyrosine Kinase (Btk) through a novel SH3-dependent interaction Manuela O. Gustafsson, A. Hussain, D.K. Mohammad, A.J. Mohamed, C. Smith, B.F. Nore; Huddinge, Sweden 97 Posters - August 23 283 P2.01.10 - Role of the long-chain fatty acids receptor GPR40 in bovine neutrophils activation Maria A. Hidalgo, J. Mena, C. Manosalva, D. Carroza, R.A. Burgos; Valdivia, Chile 284 P2.01.11 - Role of SLP-76, ADAP and Pyk2 on chemokine-stimulated T cell adhesion mediated by the integrin Alpha4-Beta1 Soledad Isern de Val, A. Dios-Esponera, J. Teixidó; Madrid, Spain 285 P2.01.12 - Regulation of apoptosis by CD45 in T cells Bruno Johnson, G. Dupéré-Minier, D. Bernier, J. Bernier; Montreal, Canada 286 P2.01.13 - The SNARE protein VAMP7 controls T cell activation by regulating recruitment and phosphorylation of Lat subsynaptic vesicles to the TCR activation sites Paola Larghi, D.J. Williamson, J. Carpier, S. Dogniaux, K. Chemin, A. Bohineust, L. Danglot, K. Gaus, T. Galli, C. Hivroz; Paris, France 287 P2.01.14 - Dual phosphorylation of Btk induced by Akt/PKB kinase regulating shuttling and attenuating signaling in B cells Dara K. Mohammad, B.F. Nore, M.O. Gustafsson, A. Hussain, A.J. Mohamed, C. Smith; Stockholm, Sweden 288 P2.01.15 - Role of SRC family kinases in the activation of ITK-SYK Abdulrahman J. Mohammed Hamasy, A. Hussain, D.K. Mohammad, M.O. Gustafsson, B.F. Nore, A.J. Mohamed, C. Smith; Stockholm, Sweden 289 P2.01.16 - CD137 Costimulation may compromise cytotoxic mediators of Natural Killer Cells Shadi Navabi, A. Hosseini, M. Jaberipour, M. Doroudchi, M. Habibagahi; Shiraz, Iran, Islamic Republic of 290 P2.01.17 - NFkB alternative pathway is activated in IgE class switching Hitomi Sakamoto, K. Tanabe, S. Inui; Kumamoto, Japan 291 P2.01.18 - Level of CD44 expression and its function distinguishes TH17 from TH1 cells Julia Schumann, K. Stanko, C. Appelt, B. Sawitzki; Berlin, Germany 292 P2.01.19 - CD28 and NKG2D-mediated costimulation regulates CD8+ T cell chemotaxis through different signaling pathways Esther Serrano-Pertierra, E. Cernuda-Morollón, C. López-Larrea; Oviedo, Spain 293 P2.01.20 - Inhibition of T cell receptor signaling by CD147 Verena Supper, H.B. Schiller, W. Paster, F. Forster, H. Stockinger; Vienna, Austria 294 P2.01.21 - IL4-induced IgE class switching is regulated by NFkB alternative pathway Kano Tanabe, H. Sakamoto, S. Inui; Kumamoto, Japan 295 P2.01.22 - During human T cell activation ERK binds to a panel of promoters and regulates the transcription of target genes Ubaid Ullah, N.C. Sahoo, P. Tripathi, R. Lahesmaa, K.V.S. Rao; Turku, Finland 296 P2.01.23 - Paracrine ATP signalling between T lymphocytes Chiuhui Mary M. Wang, F. Anselmi, J. Cibella, A. Viola; Rozzano (MI), Italy 297 P2.01.25 - The Rho Family Guanine Nucleotide Exchange Factor, FARP1 negatively regulates T cell response Yuji Yoshida, S. Kang, A. Kumanogoh; Osaka, Japan 298 P2.01.26 - Interaction between Siglec-9 and prohibitins down-regulates T cell receptor signaling Hajime Yurugi, H. Nakada; Kyoto, Japan 299 P2.01.27 - PD-1 - PD-L1 interaction does not affect the ability of dendritic-like cells to activate human lymphocytes in vitro Michał Zarzycki, K. Bocian, G. Korczak-Kowalska; Warsaw, Poland P2.10 AUTOPHAGY AND CELL DEATH IN THE IMMUNE SYSTEM Session Time: Friday, August 23, 13:20 -15:00 300 P2.10.01 - Elucidating the role of UVRAG in T cell biology Samia Afzal, H. Zhenyue, D. Brenner, T. Mak; Toronto, Canada 301 P2.10.02 - Galectin-1 is a novel component of cytotoxic granules and contributes to in vivo CTL killing Gustavo P. Amarante-Mendes, T.C. Machado, N.J. Vieira, M.J. Dominguez, T. Zorn, M. Dias-Baruffi, M.M. Rodrigues, S.J. Martin; São Paulo, Brazil 302 P2.10.03 - Autocrine and paracrine interferon- directly enhances CD8 T cell motility and contact-dependent cytotoxicity Purnima Bhat, G. Leggatt, N. Waterhouse, I. Frazer; Buranda, Australia 98 Posters - August 23 303 P2.10.04 - SLAMF-1 is a signaling receptor modulating autophagy in a subset of chronic lymphocytic leukemia patients with a good prognosis Cinzia Bologna, R. Buonincontri, S. Serra, T. Vaisitti, V. Audrito, D. Brusa, S. Deaglio; Turin, Italy 304 P2.10.05 - LPS induces intrinsic apoptosis of 6-sulfo LacNAc+ dendritic cells (slanDCs) Deseada Camuesco, F. Calzetti, M. Cassatella; Verona, Italy 305 P2.10.06 - Autophagy as a link between immunity and inflammation in idiopathic inflammatory myopathies Cristina Cappelletti, G.N.A. Vattemi, P. Tonin, F. Salerno, L. Maggi, L. Morandi, M. Mora, G. Tomelleri, R. Mantegazza, P. Bernasconi; Milan, Italy 306 P2.10.07 - O-linked N-acetylglucosaminyl transferase (Ogt) promotes the survival of mature B cells Ming-Feng Chiang, C. Wu, K. Lin; Taipei, Taiwan 307 P2.10.08 - Selective MHCII-mediated cell death as a potential mechanism for reversing inflammation in a chemically-induced mouse model of colitis Giuseppina F. Dusio, R.P. Tobin, L. Dao, S. Henderson, W. Cromer, H. Papacostantinou, M.K. Newell; Temple, United States 308 P2.10.09 - Low-density lipoprotein receptor-related protein-1 (LRP-1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA Toshiya Hirayama, K. Yahiro, M. Nakano, M. Noda, J. Moss; Nagasaki, Japan 309 P2.10.10 - Suppression of Mcl-1 via RNA interference sensitizes human U937cells towards apoptosis induction Mahdi Jafarlou, B. Baradaran, D. Shanehbandi, F. Othman; Serdang, Malaysia 310 P2.10.11 - Bcl-2 antagonist as an immunomodulatory drug for transplantation Andrew M. Lew, E.M. Carrington, I.B. Vikstrom, D.M. Tarlinton; Parkville, Australia 311 P2.10.12 - CD95 (Fas) and CD178 (Fasl) induce apoptosis in CD4+ and CD8+ cells from peripheral blood and spleen in dogs naturally infected by Leishmania spp Valéria M. Lima, B.B. Oliveira, L.M. Melo, J. Perosso, K.L.O. Silva; Araçatuba, Brazil 312 P2.10.14 - The effect of Z36 on Human T-cell Leukemia Tsukasa Nakanishi, Y. Song, J. Tsukada, T. Kanazawa, Y. Yoshida; Kitakyushu, Japan 313 P2.10.15 - An innovative method for assessing autophagy using the FlowSight imaging flow cytometer Haley R. Pugsley, R. Kong, S.L. Friend, B.E. Hall, D.A. Basiji, P. Morrissey; Seattle, United States 314 P2.10.16 - Accumulation of autophagic adaptor protein, p62/sequestosome 1, in the brains of Alzheimer’s disease Kunikazu Tanji, T. Matsumiya, A. Maruyama, S. Odagiri, F. Mori, K. Itoh, A. Kakita, H. Takahashi, K. Wakabayashi; Hirosaki, Japan 315 P2.10.17 - Interference of modified vaccinia virus Ankara with autophagy: implications for innate and adaptive immunity Kim A. Tappe, M.V. Stankov, T. Frenz, U. Kalinke, G.M.N. Behrens; Hannover, Germany 316 P2.10.18 - Mechanisms of cytotoxic effects of different monoclonal antibody to tumor-associated ganglioside GD2 Polina Vishnyakova, I. Kholodenko, I. Molotkovskaya, R. Kholodenko; Moscow, Russian Federation 317 P2.10.19 - Transcriptional control of FAS-ligand regulates the differential activation induced cell death of human Thelper cells Elisabetta Volpe, G. Ruocco, S. Santini, M. Cencioni, G. Borsellino, M. De Bardi, D. Barilà, L. Battistini; Rome, Italy 318 P2.10.20 - BCL3, induced by Tax and HTLV-1, inhibits NF-κB activation and promotes autophagy Hui Wang, J. Wang, Z. Niu, C. Gao, J. Han, X. Zhu, X. Song; Xinxiang, China 319 P2.10.21 - A protective role of autophagy as an anti-oxidant system in human primary T cells: a potential therapeutic strategy for autoimmune diseases Ryu Watanabe, H. Fujii, T. Shirai, S. Saito, T. Ishii, H. Harigae; Sendai, Miyagi, Japan 320 P2.10.22 - Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death S. Hong, I. Hwang, S. Park, Je-Wook Yu; Seoul, Korea, Republic of 321 P2.10.24 - Rapid Dynamic Exchange of LC3 in Intracellular Protein Aggregates but not in Autophagosomes L. Wang, Zhihong Zhang; Wuhan, China 99 Posters - August 23 P3.01 LYMPHOID ORGANOGENESIS AND LINEAGE COMMITMENT Session Time: Friday, August 23, 13:20 -15:00 322 P3.01.01 - The role of ADAM10 in B cell biology Natalia Chaimowitz, R. Martin, L. Dean, D. Conrad; Richmond, United States 323 P3.01.02 - Roles of Polycomb group proteins in the maintenance of T cell fate Tomokatsu Ikawa, H. Koseki, H. Kawamoto; Yokohama, Japan 324 P3.01.03 - The repression of myeloid genes by Bach family restricts common lymphoid progenitors fate to B cell lineage Ari Itoh-Nakadai, R. Hikota, M. Matsui-Watanabe, M. Kobayashi, A. Muto, K. Igarashi; Miyagi, Japan 325 P3.01.04 - FoxN1 is a Direct Transcriptional Regulator of Delta-like 4 in Thymic Stromal Cells Korosh Kianizad, H. Naik, D.K. Shah, M. Mohtashami, J.C. Zuniga-Pflucker; Toronto, Canada 326 P3.01.05 - Features of colony-forming cells-fibroblast precursors circulating in biological fluids Olga V. Lebedinskaya; Perm, Russian Federation 327 P3.01.06 - Protein kinase CK2beta is an essential regulator of peripheral B cell development Fortunato Zaffino, S. Manni, E. Mandato, L. Quotti Tubi, A. Brancalion, N. Compagno, B. Boldyreff, O. Filhol-Cochet, G. Semenzato, F. Piazza; Padova, Italy 328 P3.01.07 - Poly(ADP-ribose)polymerase-1 (PARP-1) negatively controls regulatory T cell differentiation F. Novelli, E. Bennici, F. Laudisi, M. Sambucci, Claudio Pioli; Rome, Italy 329 P3.01.08 - The critical role of NADPH oxidase on inducible bronchus-associated lymphoid tissue formation in newborn mice Ting-Jing Shen, Y. Lin, C. Shieh; Tainan, Taiwan 330 P3.01.09 - Plasticity of antigen-specific Th17 and Regulatory T Cells in response to environmental cues Gabriela P. Tejón, V. Manríquez, J.R. Mora, M.R. Bono, M. Rosemblatt; Santiago, Chile P3.03 THYMIC SELECTION AND T CELL DEVELOPMENT Session Time: Friday, August 23, 13:20 -15:00 331 P3.03.01 - Role of sonic hedgehog in T cell development Amal Al-Shammary; London, United Kingdom 332 P3.03.02 - Analysing the role of E2F7 and E2F8 in peripheral T cells and during T cell development Jane Beil, R. Sapkota, A. Sledzinska, A. de Bruin, T. Buch; Munich, Germany 333 P3.03.03 - CCL2 chemokine in central tolerance Oriane Cédile, M. Løbner, H. Toft-Hansen, I. Frank, M. Irla, T. Owens; Odense, Denmark 334 P3.03.04 - Does citrullination occur in medullary thymic epithelial cells? Robby Engelmann, A. Biemelt, A. Johl, B. Müller-Hilke; Rostock, Germany 335 P3.03.05 - Significant involvement of NF-κB-inducing Kinase in shaping mature T cell repertoire Koji Eshima, N. Shinohara, K. Iwabuchi; Sagamihara, Kanagawa, Japan 336 P3.03.06 - Homeostatic properties and phenotypic maturation of murine CD4+ pre-thymic emigrants in the thymus Qing Ge, X. Xu, J. Dong; Beijing, China 337 P3.03.07 - Transcriptional modification induced in a human epithelial cell line by transfected AIRE Carolina Guitart, F. Reyes, I. Alvarez, S. Boltaña, D. Jaraquemada; Bellaterra, Barcelona, Spain 338 P3.03.08 - SOCS1 deficiency results in fatal inflammatory disease in the absence of thymic T cells Hiromi Honda, T. Ohkawara, M. Fujimoto, S. Lee, T. Kishimoto, T. Naka; Ibaraki, Osaka, Japan 339 P3.03.09 - Regulation of CD8 T cell function by the small GTPase Arl4d Julita Kaczmarek, L. Diehl; Bonn, Germany 340 P3.03.10 - Signal integration in thymocytes is crucial for thymic selection Sahamoddin Khailaie, A. Toker, J. Hühn, M. Meyer-Hermann; Braunschweig, Germany 100 Posters - August 23 341 P3.03.11 - Vascular Endothelial Growth Factor and Semaphorin 3A influence murine thymocyte migration in vitro Ekaterina P. Kisseleva, I.V. Lyamina; St.Petersburg, Russian Federation 342 P3.03.12 - Shaping of epitope-specific CTL precursor populations by thymic selection J. Guan, W. Kan, S.J. Turner, Nicole L. La Gruta; Parkville, Australia 343 P3.03.13 - CD8aa TCRab intraepithelial lymphocytes MHC restriction S. Mayans, D. Stepniak, S. Palida, A. Larange, H. Cheroutre, Florence Lambolez; La Jolla, United States 344 P3.03.14 - The role of WW domain-containing oxidoreductase in lymphocyte development Jui-Yen Lo, L. Hsu; Tainan, Taiwan 345 P3.03.15 - The investigation of the expression of P2Y1 and P2Y2 nucleotide receptors on thymocytes using monoclonal antibodies Milda Naciute, R. Kvietkauskaite, N. Gerasimcik, J. Jursenaite, M. Mauricas, I. Girkontaite; Vilnius, Lithuania 346 P3.03.16 - Role of Miz-1 (Myc-Interacting Zinc-finger protein-1) as a regulator of p53 dependent pathways during pre TCR selection Marissa Rashkovan, C. Kosan, T. Möröy; Montreal, Canada 347 P3.03.17 - Thymic nurse cells play an important role in MHC restriction and express progenitor markers associated with epithelial maintenance Michael D. Samms; New York, United States 348 P3.03.18 - TCRβ but not the TCRδ enhancer exerts transcriptional control on the TCR locus during development Ravindra M. Sapkota, A. Sledzinska, C. Uthoff-Hachenberg, B. Becher, T. Buch; Zurich, Switzerland 349 P3.03.19 - Pharmacological inhibition of glycogen synthase kinase 3 regulates T cell development in vitro Jan-Hendrik Schroeder, L. Bell, M. Janas, M. Turner; London, United Kingdom 350 P3.03.20 - Role of conserved MHC residues for interaction with T cell antigen receptors Daniel Silberman, P. Marrack, J.W. Kappler; Denver, United States 351 P3.03.21 - Generation of a conditional knock-out mouse for SATB1 to study its importance for CD4+ T cells Daniel Sommer, A. Peters, T. Wirtz, M. Mai, Y. Thabet, J. Degen, J.L. Schultze, M. Beyer; Bonn, Germany 352 P3.03.22 - Themis CABIT domains exert distinct functions in thymocyte positive selection Harumi Suzuki, T. Okada, T. Nitta, K. Kaji, H. Oda, M.S. Ppatrick; Ichikawa-shi, Chiba, Japan 353 P3.03.23 - Background of Primary Immunodeficiencies in Patients with Severe Atopic Dermatitis Babak Torabi Sagvand, A. Aghamohammadi, Z. Gholizadeh Moghaddam, B. Mirminachi, H. Abolhassani, Z. Hallaji, H. Mortazavi, H. Mortazavi, P. Mohammadinejad; Tehran, Iran, Islamic Republic of 354 P3.03.24 - A single cell approach to investigating the role of asymmetric cell division in fate determination of CD8+ T cells Mohammed Yassin, R. Shimoni, K. Pham, J. Oliaro, M. Ludford-Menting, S. Russell; Melbourne, Australia 355 P3.03.25 - Thymectomy in early childhood: decrease of naive CD4+ T cells and diminished immune response after vaccination Manuela Zlamy, C. Gögele, R. Würzner, R. Geiger, L.B. Zimmerhackl, M. Prelog; Innsbruck, Austria P4.13 IMMUNE REGULATION AT BARRIER SITES Session Time: Friday, August 23, 2013 1:20:00 PM - 3:00:00 PM 356 P4.13.01 - Host defense peptide CRAMP acts as a potent mast cell chemoattractant and mediator release stimulus Edyta Bolewska, P. Witczak, A. Słodka, A. Pietrzak, E. Brzezi ska-Błaszczyk; Łód , Poland 357 P4.13.02 - Chemerin is an antimicrobial agent in human epithelium Magdalena Banas, K. Zabieglo, M. Kapinska-Mrowiecka, J. Drukala, K. Murzyn, B.A. Zabel, E.C. Butcher, J.M. Schroeder, A. Schmidtchen, J. Cichy; Cracow, Poland 358 P4.13.03 - Bcl3 expression is increased in Irritable Bowel Syndrome (IBS) patients independently of IL-10 Caroll J. Beltrán, A.M. Madrid, C. Defilippi, K. Nally, S. Melgar, J.F. Cryan, T.G. Dinan, E.M. Quigley; Santiago, Chile 359 P4.13.04 - Soluble factor produced by Staphylococcus aureus modulates the cell cycle of eukaryotic cells Nadia Nadejda Berkova, E. Ladier, L. Alexseeva, M. Deplanche, S. Almeida, V. Azevedo, S. Even, F. Taieb, Y. Arlot-Bonnemains, Y. Le Loir; Rennes, France 101 Posters - August 23 360 P4.13.05 - Characterization of a lymphocyte inhibitor from Aedes aegypti saliva Bruna Bizzarro, M.S. Barros, A.D. Ramos, J. Campopiano, D.I. Gueroni, G.P. Amarante-Mendes, E. Calvo, J.M. Ribeiro, M.L. Capurro, A. Sá-Nunes; São Paulo, Brazil 361 P4.13.06 - Expression and regulation of TSLP in human oral mucosa and cultured oral keratinocytes Louise Bjerkan, O. Schreurs, L. Farkas, F. Jahnsen, E. Baekkevold, I. Blix, K. Schenck; Oslo, Norway 362 P4.13.07 - Induction of Interleukin-10 expression by the commensal microbiota in intestinal regulatory T-cells Julia Bollrath, M. Barnes, A. Johnson, M. Asquith, H. Waldmann, R. Flavell, S. Hori, K. Maloy, F. Powrie; Oxford, United Kingdom 363 P4.13.08 - Helicobacter pylori HP0175 promotes the production of IL-23, IL-6, IL-1β and TGF-β Chiara Della Bella, A. Amedei, F. Munari, E. Niccolai, M. Benagiano, G. Zanotti, M. de Bernard, M. Kundu, M.M. D’Elios; Florence, Italy 364 P4.13.09 - Mechanistic insights into Helicobacter pylori pathogenesis and host response Bow Ho; National University of Singapore, Singapore 365 P4.13.10 - Intestinal mucosal barrier in experimentally induced septic shock and gut inflammation Michaela Hornova, Z. Zakostelska, K. Klimesova, J. Hrdy, H. Tlaskalova - Hogenova, M. Kverka; Prague, Czech Republic 366 P4.13.11 - Homeostatic proliferation of naïve CD4+ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells Takeshi Kawabe, S. Sun, A. Asao, T. Takahashi, T. So, N. Ishii; Sendai, Japan 367 P4.13.13 - The flagellin sensor NLRC4 mediates protection against a mucosal pathogen Sofia Nordlander, K.J. Maloy; Oxford, United Kingdom 368 P4.13.14 - Brucella abortus 2308 induce downregulation of the activation markers in murine B cells Maricela Ramírez-Saldaña, V. Paredes- Cervantes, M. Aguilar-Santelises, J.M. Hernández- Dominguez, M.C. Moreno-Lafont, R. LópezSantiago; México D.F., Mexico 369 P4.13.15 - Transcription factor Spi-B-dependent and -independent pathways for the development of Peyer’s patch M cells Shintaro Sato, S. Kaneto, H. Kiyono; Tokyo, Japan 370 P4.13.16 - Influenza virus infection induces long-term and compartmentalised derangement of airway and lung dendritic cell subsets Philip A. Stumbles, C. von Garnier, M. Smith, V. Fear, E. Bozanich, C. Berry, D. Strickland, P. Holt; Perth, Australia 371 P4.13.17 - Translation of Tollip is inhibited in the small but not large intestinal epithelial cells Yutaka Sugi, K. Takahashi, T. Kobayakawa, A. Hosono, S. Kaminogawa; Fujisawa-shi Kanagawa, Japan 372 P4.13.18 - Monoclonal intestinal IgAs are poly-reactive against commensal bacteria but recognize a single protein expressed by multiple bacteria Fumihito Usui, S. Okai, M. Hasegawa, R. Shinkura; Nagahama, Japan 373 P4.13.19 - Density of FOXP3+ T cells and CD11c+ dendritic cells in small bowel mucosa in children with atopic dermatitis, celiac disease and functional gastrointestinal disorders Tamara Vorobjova, K. Ress, K. Lepik, K. Luts, O. Uibo, R. Uibo; Tartu, Estonia 374 P4.13.20 - Foxp3+ regulatory T cells promote a protective Th17 cell response against intestinal infection with Citrobacter rodentium Zuobai Wang, S. Cording, S.C. Pohl, C. Friedrich, G. Eberl, T. Sparwasser, M. Lochner; Hannover, Germany 375 P4.13.21 - Toward prediction of immune signatures of health Nicholas P. West, P.L. Horn, D.B. Pyne, L. Lee, S. Asad, S.J. Lahtinen, M. Lehtinen, P.A. Fricker, B. Fazekas de St Groth, A.W. Cripps; Gold Coast, Australia P5.01 CYTOKINE REGULATION IN DISEASE Session Time: Friday, August 23, 13:20 -15:00 376 P5.01.01 - Study of IL-23 expression level in liver transplanted patients Afsoon Afshari, R. Yaghoobi, M. Karimi, M. Darbouy; Shiraz, Iran, Islamic Republic of 377 P5.01.02 - Effects of dexamethasone on IL-6 and IL-8 expression induced by TGF-β1 in colon cancer cells Omair Al Shahrani, M. Alanazi, A. Semlali; Riyadh, Saudi Arabia 378 P5.01.03 - Antitumor effect of a hydroalcoholic extract of Uncaria tomentosa in a murine C57BL/6- B16 melanoma model Yubell P. Alvarez Valdivia, I. Lozada-Requena, C. Núñez, S. Dávila, T. Ysmodes, A. Vaisberg, C. Acuña, J.L. Aguilar; Lima, Peru 102 Posters - August 23 379 P5.01.04 - Modulation of Oxido-Nitrosative Stress Induced Neuro-Inflammatory Cascade & Monoaminergic Pathway By Resveratrol In Reserpine Induced Pain Depression Dyad In Rats Vipin Arora, K. Chopra; Chandigarh, India 380 P5.01.05 - Maternal cytokine production patterns in women with pre-eclampsia Fawaz Azizieh, R. Raghupathy, M. Makhseed; Kuwait, Kuwait 381 P5.01.06 - Suppressive Role of IL-27 against Pro-inflammatory Role of IL-17A in Patients with Multiple Sclerosis Zohreh Babaloo, R. Kh. Yeganeh, M. farhoodi, B. Baradaran, M. Boniadi; Tabriz, Iran, Islamic Republic of 382 P5.01.07 - Immune mechanisms in periodontitis - effect of IL-4 gene polymorphisms on cytokine production Jirina Bartova, P. Borilova Linhartova, S. Podzimek, K. Svobodova, T. Janatova, A. Fassmann, J. Duskova, L. Izakovicova-Holla; Prague, Czech Republic 383 P5.01.08 - Concentration Levels of IL -10 and TNF-α Cytokines in Patients with HPV DNA Positive and Negative Cervical Lesions Husham Y.M. Bayazed; Zakho, Iraq 384 P5.01.09 - The inflammatory cytokine TNFalpha cooperates with hyper-activated Ras in promoting metastasis and turns WT-Ras into an oncogenic entity T. Leibovich-Rivkin, Y. Liubomirski, T. Meshel, A. Abahidze, A. Abahidze, D. Brisker, H. Solomon, V. Rotter, M. Weil, Adit Ben-Baruch; Tel Aviv, Israel 385 P5.01.10 - Cytokines, depression, and anxiety in patients with colorectal cancer D.O. Miranda, L.R. Azevedo, T.A.S. Lima, O. Feres, J.J.R. Rocha, Gabriela S. Bisson; Ribeirão Preto, Brazil 386 P5.01.11 - IL-17 protects T cells from apoptosis and contributes to development of ALPS-like pictures Elena Boggio, N. Clemente, U. Ramenghi, U. Dianzani, A. Chiocchetti; novara, Italy 387 P5.01.12 - Haplotype analysis of interleukin-8 gene polymorphisms in chronic and aggressive periodontitis Petra Borilova Linhartova, J. Vokurka, H. Poskerova, A. Fassmann, L. Izakovicova Holla; Brno, Czech Republic 388 P5.01.13 - Analysis of Th17 cells and IL-17, IL-23 cytokines in peripheral blood from children with autoimmune thyroid disease Artur A. Bossowski, M. Moniuszko, M. Dabrowska, M. Jeznach, A. Bossowska, M. Rusak, A. Bo ena-Lukaszyk; Bialystok, Poland 389 P5.01.14 - Cryoglobulins are involved in pathomechanisms of altered immune response associated with schizophrenia and ischemic stroke Anna Boyajyan, A. Chavushyan, M. Hovsepyan, M. Hovhannisyan; Yerevan, Armenia 390 P5.01.15 - IL-17 plays a critical pathogenic role in lung cancer Seon Hee Chang, S. Mirabolfathinejad, A. Cumpian, C. Ochoa, L. Gong, S. Moghaddam, C. Dong; Houston, United States 391 P5.01.16 - Effects of imiquimod treatment on TNF expression in two-step skin carcinogenesis model in mice Anna A. Chashchina, S.V. Bozrova, R.V. Zvartsev, T. Kammertoens, V.A. Levitsky, S.A. Nedospasov, M.S. Drutskaya; Moscow, Russian Federation 392 P5.01.17 - Interferon gamma supresses collagen-induced arthritis through regulation of IL-17 : possible role of indoleamine 2,3 deoxygenase Mi-La Cho, J. Jhun, M. Lim, J. Lee, J. Lee, S. Park; Seoul, Korea, Republic of 393 P5.01.18 - GLK controls Th17-mediated autoimmunity and NF-κΒ signaling by activating PKC-θ in T cells Huai-Chia Chuang, J. Lan, D. Chen, T. Tan; Zhunan Miaoli County, Taiwan 394 P5.01.19 - Immune response to a mixture of bacterial lysates in a rat model Dagoberto Cid Guerrero, J. Martinez Castillo, I. Vargas Rodriguez, S. Sanchez Rodriguez, R. Ramirez Santoyo, E. Lopez Robles; Zacatecas, Mexico 395 P5.01.20 - Regulation of lymphoma B cell proliferation by IL-31 and its receptor E. Ferretti, G. Pagnan, C. Guarnotta, G. Fraternali-Orcioni, S. Zupo, C. Tripodo, V. Pistoia, Anna Corcione; Genova, Italy 396 P5.01.21 - Evaluation of potential serum biomarkers for periodontal disease in type 1 diabetes mellitus children Cristiane Duque, M.F. Dib, F.S. Mariano, G.A.C.G. Camargo, N.H. Colombo, R.O. Mattos-Graner; Araçatuba, Brazil 397 P5.01.22 - Influence of TLR2 in the cytokine profile after S. schenckii infection Cristiane Duque, T.d. Negrini, L.S. Ferreira, P. Alegranci, M.C.P. Placeres, R.A. Arthur, L.C. Spolidorio, I.Z. Carlos; Araçatuba, Brazil 398 P5.01.23 - Lack of correlation between IL-21 and type I IFN signature suggests different roads to pathogenesis in Rheumatoid Arthritis Rachel Ettinger, J.L. Karnell, C.A. Morehouse, E. Grant, D. Taylor, M. Wilson, R. Goldbach-Mansky, Y. Yao, R. Herbst, L. Carter; Gaithersburg, United States 103 Posters - August 23 399 P5.01.25 - Expression of cytokine and Chemokine receptors on benign and malignant ovarian tissues Abbas Ghaderi, S. Rezaeifard, M. Razmkhah, M. Robati, M. Momtahan; Shiraz, Iran, Islamic Republic of 400 P5.01.26 - Role of transcription factor and chromatin remodeler interplay in the regulation of TNFα induced MHC-I gene expression Sadashib Ghosh, E. Sen; Gurgaon, India 401 P5.01.27 - BET bromodomain inhibition by JQ1 suppresses interleukin-6 secretion in myeloma cells Rohit R. Ghurye, H.J.S. Stewart, T.J. Chevassut; Brighton, United Kingdom 402 P5.01.28 - Dynamics of IL-1ά, IL-4 and IFN-γ in children with atopic asthma in therapy Leukinferon Naila M. Gulieva; Baku, Azerbaijan 403 P5.01.29 - Cellular responses to Staphylococcus aureus alpha-toxin in chronic rhinosinnusitis with nasal polyps Takenori Haruna, M. Okano, S. Kariya, T. Koyama, K. Nishizaki; Okayama, Japan 404 P5.01.30 - Imbalance of homeostatic cytokines in APECED Nelli Heikkilä, S.M. Laakso, H. Jarva, T.P. Arstila; Helsinki, Finland 405 P5.01.31 - Substantially elevated plasma IL-1β levels and hyporeactivity to IL-1β in APECED Iivo Hetemäki, V. Veckman, H. Jarva, S. Matikainen, T.P. Arstila; Helsinki, Finland 406 P5.01.32 - Effects of Siegesbeckia orientalis ethanol extract on systemic and local inflammatory reactions Yong-Han Hong, J. Houng; Kaohsiung, Taiwan 407 P5.01.33 - Metformin modulates inflammatory response through AMPK-NF-κB signaling and restores atherogenic effects Bobae Hyun, S. Shin, A. Lee, S. Lee, Y. Song, K. Cho, K. Kim; Seoul, Korea, Republic of 408 P5.01.34 - Immunomodulatory effects of N-(2-hydroxy phenyl) acetamide on pro-inflammatory cytokines and ROS in adjuvant-induced arthritic rats Huma Jawed, S. Jamall, S.U. Simjee; Karachi, Pakistan 409 P5.01.35 - Redox balance of mouse medullary CD4 single positive thymocytes Rong Jin; Beijing, China 410 P5.01.36 - Low level of TNF-alpa in cystic fluid is accompanied with low number of macrophages in cystic wall of odontogenic tumor Vladimir Jurisic, T. Terzic, M. Jurisic; Kragujevac, Serbia 411 P5.01.37 - Effect of immunoglobulin E on plasmacytoid dendritic cells in systemic lupus erythematosus pathogenesis through interferon-alpha downregulation Liliane Khoryati, I. Douchet, C. Contin-Bordes, P. Blanco, C. Richez; Bordeaux, France 412 P5.01.38 - Correlation of some Inflammation related cytokines and biochemical markers amongst individuals with high, medium and normal serum FBS levels Afra Khosravi, F. Nasiri, K. Sayemiri; Ilam, Iran, Islamic Republic of 413 P5.01.39 - Critical roles of oncostatin M receptor signaling on the polarization of macrophage phenotypes, adipose tissue inflammation, and the development of insulin resistance Tadasuke Komori, M. Tanaka, E. Senba, A. Miyajima, Y. Morikawa; Wakayama, Japan 414 P5.01.40 - Serum soluble IFNAR2 levels in autoimmune diseases suggest that chronic IFN signaling leads to elevated levels of sIFNAR2 T. Fatakdawala, M. Skawinski, T. Stauffer, J. Ferriera, Thomas B. Lavoie; Piscataway, United States 415 P5.01.41 - IL-4: a key cytokine in acutely rejected neo-antigen specific skin grafts Victoria M. Leb-Reichl, S. Kitzmueller, D. Peckl-Schmid, M. Ettinger, H. Hintner, J.W. Bauer; Salzburg, Austria 416 P5.01.42 - Aryl hydrocarbon receptor negatively regulates type I interferon production in murine lupus Soyoung Lee, R. Barry, I. Chinen, D. Millrine, T. Kishimoto; Osaka, Japan 417 P5.01.43 - Proinflammatory cytokines in patients with chronic traumatic encephalopathy Yevgeniya Lekomtseva, G. Gubina-Vakulik; Kharkiv, Ukraine 418 P5.01.44 - Effect of lithium carbonate treatment in mRNA levels of pro- and anti-inflammatory cytokines and expression of Wnt/beta-catenin pathway genes in PBMC of bipolar patients Maria C.A. Luque, T.M. Ali, C. Moreira, B. Lafer, J. Kalil, E. Cunha-Neto; São Paulo, Brazil 104 Posters - August 23 419 P5.01.48 - Anti-inflammatory effects of high-dose IgG on TNF-α-, but not IL-1β-activated human coronary artery endothelial cells Akio Matsuda, H. Morita, H. Unno, K. Motomura, H. Saito, K. Matsumoto, J. Abe; Tokyo, Japan 420 P5.01.49 - Association of modulatory cytokine gene polymorphisms in resistance and susceptibility to polyparasitism infection in Zimbabwe Takafira Mduluza, N. Midzi, P. Chitongo, E. Gori, T. Ruwona, G. Mlambo, S.L. Mutambu, N. Kumar; Harare, Zimbabwe 421 P5.01.50 - Interleukin-17A involvement in host defense against Echinococcus granulosus infection Dalila Mezioug, C. Touil-Boukoffa; El-Alia, Algeria 422 P5.01.51 - Interleukin-17A involvement in host defense against Echinococcus granulosus infection Dalila Mezioug, C. Touil-Boukoffa; Algiers, Algeria 423 P5.01.52 - EBI3 functions as an intracellular molecule to regulate the development of colitis in naive CD4+CD25- T cells Izuru Mizoguchi, K. Mitobe, R. Tsunoda, K. Higuchi, J. Mizuguchi, T. Yoshimoto; Tokyo, Japan 424 P5.01.53 - Prostaglandin D2 represents contradicting roles in dermatitis H. Sarashina, Y. Tsubosaka, K. Aritake, T. Nakagawa, M. Hori, H. Ozaki, Y. Urade, Takahisa Murata; Tokyo, Japan 425 P5.01.54 - ST2/IL-33 signaling worsens immune-mediated hepatitis from drug haptens S. Goodman, J. Cho, L. Kim, M. Haham, Dolores Njoku; Baltimore, United States 426 P5.01.55 - Lack of TNF-Rp55 delays thrombus resolution in a stasis-induced DVT model through reduced MMPs and uPA expression Mizuho Nosaka, Y. Ishida, A. Kimura, Y. Kuninaka, N. Mukaida, T. Kondo; Wakayama, Japan 427 P5.01.56 - Impaired production of IL-10 in response to Staphylococcus aureus alpha-toxin is closely associated with pathophysiology and postoperative outcome in chronic rhinosinusitis with nasal polyps Mitsuhiro Okano; Okayama, Japan 428 P5.01.57 - IL6 trans-signaling promotes functional recovery of hypofunctional phagocytes through STAT3 activation during peritonitis Tsuyoshi Onogawa, T. Saito-Taki, H. Yamamoto, T. Wada; Hachioji, Tokyo, Japan 429 P5.01.58 - Cytokines as molecular biomarkers for cancer cachexia Claudia Penafuerte, J. Sirois, M.L. Tremblay, B. Gagnon; Montreal, Canada 430 P5.01.59 - Cytokine profile changes following exposure to Hemiscorpius lepturus scorpion venom under experimental conditions Mohammad Hassan Pipelzadeh, A. Khodadadi, Y. Heike, M. Assarehzadegan, M. Assarehzadegan, B. Vazirianzadeh; Ahvaz, Iran, Islamic Republic of 431 P5.01.60 - The knock-out of TWEAK receptor/Fn14 ameliorates lupus nephritis in MRL/lpr mice Y. Xia, L. Herlitz, L. Burkly, R. Pawar, S. Gindea, P. Wu, J. Michaelson, Chaim Putterman; Bronx, United States 432 P5.01.61 - Inhibiting TWEAK (TNF-like weak inducer of apoptosis) signaling ameliorates neuropsychiatric disease in MRL/lpr mice Chaim Putterman; Bronx, United States 433 P5.01.63 - Serum level of immunoglobulins in patients with respiratory allergic diseases Badrossadat Rahnama, B. Hazhirkarzar, H. Ghaffari, M. Zamanlu; tabriz, Iran, Islamic Republic of 434 P5.01.64 - The electromagnetic fields affect T-helper balance in rats Badrossadat Rahnama, M. Zamanlu, B. Hajir Karzar, M. Bonyadi, A. Khaki; Tabriz, Iran, Islamic Republic of 435 P5.01.65 - TWEAK Affects Keratinocyte G2/M Growth Arrest and Induces Apoptosis through the Translocation of the AIF Protein to the nucleus Sanaa Sabour Alaoui; El Jadida, Morocco 436 P5.01.66 - PI3K/PTEN axis in APCs is regulating Th17-dependent autoimmune pathology Emine Sahin, V. Saferding, J. Brunner, J. Kral, N. Neuwinger, I. Kollmann, K. Thell, S. Blüml, G. Schabbauer; Vienna, Austria 437 P5.01.67 - Cytokine patterns during high-risk human papillomavirus and HIV co-infection in cervical cancer patients and controls in Kwazulu-Natal (South Africa) Devamani Sebastian, A.G. Assounga; Durban, South Africa 438 P5.01.68 - Mechanisms of immunosuppression and interleukin 2 in complex treatment of severe acute pancreatitis Mariya Shavarova, S. Chooklin; Lviv, Ukraine 105 Posters - August 23 439 P5.01.69 - Tuberculosis infection diagnosis by Quantiferon TB Gold In-Tube Test assessment in Namibian patients Jacob A. Sheehama, J.J. Nelongo, E.E. Nepolo, S.N. Iipinge; Windhoek, Namibia 440 P5.01.70 - Antiplatelets drugs reduces the immunoinflammatory response in a rat model of periodontal disease Luís Carlos Spolidorio, J. Steffens, M. Nicolas Muscará, C. Rossa Jr, D. Graves, L. Santana Coimbra; Araraquara, Brazil 441 P5.01.71 - Vitamin D and Interferon-beta act synergistically at physiological levels to modulate cytokine expression in vitro in peripheral blood mononuclear cells Niall J. Stewart, S. Simpson Jr., B. Taylor; Hobart, Australia 442 P5.01.72 - Carbon monoxide (CO) as a novel approach for treatment of islet-directed autoimmunity Stanislava Stosic-Grujicic, I. Nikolic, M. Vujicic, T. Saksida, F. Nicoletti, I. Stojanovic; Belgrade, Serbia 443 P5.01.73 - IL-2 induces robust inflammatory responses in the lung that synergize with influenza virus to exacerbate immunopathology Tara M. Strutt, K.K. McKinstry, S.L. Swain; Worcester, United States 444 P5.01.74 - Lnk/Sh2b3, an intracellular adaptor associated with celiac disease and autoimmune diabetes, regulates accumulation of inflammatory T cells and prevents intestinal villous atrophy T. Mori, H. Katayama, Y. Iwasaki, Y. Seki, M. Iseki, M. Ikutani, N. Yoshida, K. Takatsu, Satoshi Takaki; Ichikawa, Chiba, Japan 445 P5.01.76 - Role of TNF-α, their receptors and gene‘s polymorphism in patients with coronary atherosclerosis Ekaterina Turmova, A. Silaev, E. Shkorik, E. Markelova, R. Cromovoy; Vladivostol, Russian Federation 446 P5.01.78 - Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity Yufeng Yin, Y. Li, L. Zhao, S. Qian, L. Tong, D. Ba, W. He, X. Cao, X. Zhang, P. Lipsky; Beijing, China 447 P5.01.79 - BAFF induces IL-6 production in human monocytes through signaling pathways that involve NF-kB and PI3 kinase Keiko Yoshimoto, M. Tanaka, M. Kojima, H. Ogata, K. Suzuki, H. Kameda, T. Abe, T. Takeuchi; Tokyo, Japan 448 P5.01.80 - Increased levels of IL-6, TNF-a, MIF, IL-8, and MCP-1 in schizophrenia Roksana Zakharyan, S. Atshemyan, A. Boyajyan; Yerevan, Armenia 449 P5.01.81 - Assay of IL-22/IL-25 in serum, whole blood and peripheral blood mononuclear cells cultures of patients with severe asthma Alireza Zamani, E. Nadi, M. Arjipour, S. Sharifi; Hamadan, Iran, Islamic Republic of 450 P5.01.82 - Status of cytokine line and morphological changes in endocrine glands of rats with tentative thyrotoxicosis Victoria Zdor (Lazanovich), E. Markelova, Y. Tikhonov; Vladivostok, Russian Federation 451 P5.01.83 - Lithium treatment reduced microglia activation and inflammation after irradiation to the immature brain Changlian Zhu, K. Zhou, C. Xie, K. Blomgren; Göteborg, Sweden P5.02 CHRONIC INFLAMMATION AND FIBROSIS Session Time: Friday, August 23, 13:20 -15:00 452 P5.02.01 - IL-17 and IFNγ decrease in the gut of rats with experimental fibrosis. “Possible association with bacterial translocation” Miriam R. Bueno Topete, E. Sánchez, S. Zepeda Morales, E. Rodríguez, S. del Toro Arreola, L. García Benavides, M. Fafutis Morris, A. Domínguez, F. Muñoz Valle; Guadalajara, Mexico 453 P5.02.02 - Experimenrtal cholestasis is associated with increased IL-17 and IFN-γ expression S.M. Zepeda Morales, S. del Toro Arreola, M. Fafutis Morris, E. Bastidas Ramírez, V. Delgado Rizo, Miriam R. Bueno Topete; Guadalajara, Mexico 454 P5.02.03 - ITF2357 inhibits corneal fibrosis and inflammation via JAK/STAT3 signaling pathway Shyam S. Chaurasia, A. Tan, R. Lim, Y. Liu, J.S. Mehta; Singapore, Singapore 455 P5.02.04 - Osteopenia and inflammation in postmenopausal women L. Ginaldi, Fedra Ciccarelli, M. De Martinis; L’Aquila, Italy 456 P5.02.05 - Type 2 Innate Lymphoid Cells (ILC2) are present in mouse models of lung and skin fibrosis and their numbers correlate with disease severity Preeta Dasgupta, T. Burwell, R. Johnson, J. Bakken, R. Herbst, J. Connor, R. Lemaire; Gaithersburg, United States 457 P5.02.06 - Prevalence of skin sensitivity to aeroallergens in Iranian patients with nasal polyposis Mohammad Fereidouni, M. Bakhsahee, S. Nourani hasan kiadeh; Birjand, Iran, Islamic Republic of 106 Posters - August 23 458 P5.02.07 - Crucial role of basal p53 in attenuation of inflammation and fibrosis in hereditary glomerular nephritis, Alport syndrome Ryosuke Fukuda, K. Koyama, T. Koga, Y. Kai, K. Omachi, K. Motomura, M.A. Suico, T. Shuto, H. Kai; Kumamoto, Japan 459 P5.02.08 - Intramuscular administration of MMP-8 adenoviral vector reduces inflammation up-grade induced by vector delivery and allows prevention of liver fibrosis Jesus García-Bañuelos, E. Oceguera-Contreras, D. Gordillo-Bastidas, A. Sandoval-Rodríguez, B. Bastidas-Ramírez, J. González-Cuevas, J. Macias-Barragan, B. Gómez-Meda, J. Armendariz-Borunda; Guadalajara, Mexico 460 P5.02.09 - Mac-3 positive and enlarged foamy macrophage as an effector in radiation-induced pulmonary fibrosis H. Park, Sung-Kee Jo, U. Jung; Jeongeup-si, Korea, Republic of 461 P5.02.10 - Mild electrical stimulation with heat shock ameliorates nephritis and proteinuria in mouse model of X-linked alport syndrome Yukari Kai, T. Koga, R. Fukuda, S. Morino-Koga, M.A. Suico, K. Koyama, T. Sato, T. Shuto, H. Kai; Kumamoto, Japan 462 P5.02.11 - Interleukin-17 isoforms are differentially expressed in the skin of Systemic Sclerosis and Morphea patients compared to healthy skin Paola Adele Lonati, N. Brembilla, L. Fontao, E. Laffitte, G. Kaya, P. Meroni, C. Chizzolini; Milan, Italy 463 P5.02.12 - IL-33 precursor drives inflammation without engaging T1/ST2 or Th2 Irina G. Luzina, V. Lockatell, N.W. Todd, S.P. Atamas; Baltimore, United States 464 P5.02.13 - 5-methyl-1-phenyl-2-(1H)-pyridone reveals immunomodulatory anti-fibrotic effects associated to antioxidant system activation in primary culture of human Hepatic Stellate Cells Jose Macias-Barragan, A. Caligiuri, E. Novo, M. Parola, J. Vera-Cruz, J. García-Bañuelos, S. Lucano-Landeros, M. Pinzani, J. Armendáriz-Borunda; Ameca, Mexico 465 P5.02.14 - Phenotypical characterization of the peripheral blood T cells in celiac disease patients Mohsen Masjedi, H. Hossein Nataj Arab, M. Emami, F. AlSahebfosoul, M. Mokhtari; Isfahan, Iran, Islamic Republic of 466 P5.02.15 - GSK-3: a key mediator of the balance between matrix-metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in bleomycin (BLM) - induced pulmonary fibrosis Barbara Montini, F. Cinetto, M. Gnoato, N. Compagno, C. Gattazzo, F. Piazza, F. Lunardi, F. Calabrese, G. Semenzato, C. Agostini; Padova, Italy 467 P5.02.16 - Genes affecting MMP expression are down-regulated in patients with COPD and bronchial asthma Zdenka Navratilova, T. Krsjakova, E. Novosadova, J. Zatloukal, V. Kolek, M. Petrek; Olomouc, Czech Republic 468 P5.02.17 - Altered response of tympanosclerotic fibroblasts to interacting mast cells: implication for tissue remodeling Tadeusz K. Pawelczyk, M. Sakowicz-Burkiewicz, J. Kuczkowski; Gdansk, Poland 469 P5.02.18 - The crosstalk of kinin receptors on Experimental Focal and Segmental Glomerulosclerosis Rafael L. Pereira, R. Felizardo, M. Cenedeze, M. Hiyane, R.C. Silva, C.F. Aguiar, J.B. Pesquero, R.C. Araújo, A.P. Silva, N.O.S. Câmara; São Paulo, Brazil 470 P5.02.19 - M2 muscarinic acetylcholine receptor modulates rat airway smooth muscle cell Proliferation Fabiola A. Placeres-Uray; Caracas, Venezuela, Bolivarian Republic of 471 P5.02.20 - Periostin modulates the course of IL-13 dependent chronic inflammation and liver fibrosis Thirumalai R. Ramalingam, A. Talley, M.M. Mentink-Kane, T.A. Wynn; Bethesda, United States 472 P5.02.21 - In vivo multi-photon molecular imaging technique visualizes immune and inflammatory cell cross-talks in metabolic diseases Nishimura Satoshi, M. Nagasaki; Tokyo, Japan 473 P5.02.22 - Metformin modulates lipolysis and inflammation through the modulation of T cell priming in obese-induced Type II diabetic mice Seulmee Shin, B. Hyun, A. Lee, S. Lee, H. Kong, S. Han, Y. Song, K. Kim; Seoul, Korea, Republic of 474 P5.02.24 - High-mobility group box 1, actively secreted by cardiac fibroblasts, might be a novel culprit of myocardial contractility dysfunction and cardiac collagen deposition Zhaoliang Su, J. Yin, R. Ma, T. Wang, F. Kong, H. Shen, H. Xu; Zhenjiang, China 475 P5.02.25 - Knee injury with concomitant osteochondral fracture is associated with increased synovial fluid concentrations of SPARC, IL-8 and TNF-α Per Swärd, A. Struglics, M. Englund, H. Roos, R. Frobell; Lund, Sweden 107 Posters - August 23 476 P5.02.26 - Implication of antigen-driven mechanisms in the pathogenesis of interstitial pneumonia associated with polymyositis Akira Takeda, Y. Fukushima, T. Matsutani, Y. Haji, R. Rokutanda, Y. Suyama, M. Kishimoto, K. Yamaguchi, M. Okada; Nasushiobara, Japan 477 P5.02.27 - Intrinsic epithelial activation in Primary Sjogren’s syndrome: Evidence of significantly reduced constitutive expression of PPAR-gamma in cultured non-neoplastic salivary gland epithelial cell lines Aigli G. Vakrakou, A. Kapogiannatou, V. Gourzi, E.K. Kapsogeorgou, M.N. Manoussakis; Athens, Greece 478 P5.02.28 - IL28B polymorphisms may be associated with Chlamydia pneumoniae infection in patients with cardiac disease Antonio C. Vallinoto, B. Brasil Santana, N. Almeida, R. Bezerra Hermes, R. Ishak, M.O.G. Ishak; Belem, Brazil 479 P5.02.29 - Accumulation of tolerogenic cells at the site of granulomatous foreign-body reaction Dragana Vucevic, S. Vasilijic, J. Djokic, B. Bozic, I. Majstorovic, S. Tomic, M. Vasiljevska, B. Draskovic-Pavlovic, M. Colic; Belgrade, Serbia 480 P5.02.30 - EBP-1 specific T cell responses correlate with liver damage in chronic hepatitis B Li Wang, l. Jiang, X. Chen, X. Chen, Y. Wu; Chongqing, China 481 P5.02.31 - Human kidney proximal tubule epithelial cells (PTEC) modulate autologous immune responses by contact dependent mechanisms Ray Wilkinson, S. Sampangi, A. Kassianos, X. Wang, H. Healy; Brisbane, Australia 482 P5.02.32 - Systemic inflammation in patients with end-stage renal disease (ESRD) receiving different types of renal replacement therapy L.V. Solomatina, Iuliia Zhuravleva, E. Panshina, E. Gusev; Ekaterinburg, Russian Federation P5.08 ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASES Session Time: Friday, August 23, 13:20 -15:00 483 P5.08.01 - Elevated vascular adhesion protein-1 (VAP-1) levels in cardiovascular disease events Kristiina Aalto, M. Maksimow, S. Jalkanen, V. Salomaa, M. Salmi; Turku, Finland 484 P5.08.02 - ROS and RNS signaling in cardiovascular diseases: Could antioxidants be useful? Igor B. Afanas’ev; Porto, Portugal 485 P5.08.03 - Serum amyloid A stimulates macrophage foam cell formation via formyl peptide receptor 2 Yoe-Sik Bae, H. Lee, S. Kim, S. Baek, J. Choi, K. Cho, E. Cho, B.A. Zabel; Suwon, Korea, Republic of 486 P5.08.05 - Elevated CD14++CD16- monocytes predict cardiovascular events K.E. Berg, I. Ljungcrantz, L. Andersson, C. Bryngelsson, B. Hedblad, G.N. Fredrikson, J. Nilsson, Harry Björkbacka; Malmö, Sweden 487 P5.08.06 - T-helper 2 immunity is associated with reduced risk of myocardial infarction and stroke L. Andersson, D. Engelbertsen, I. Ljungcrantz, M. Wigren, B. Hedblad, J. Nilsson, Harry Björkbacka; Malmö, Sweden 488 P5.08.07 - Identification of NOD like receptors (NLRs) in human atheroma lesions R.T.D. Oliveira, M.F. Mineiro, R.M. Silva, M.R. Paiao, R.L. Mamoni, F.H. Menezes, Maria H.S.L. Blotta; Campinas, Brazil 489 P5.08.08 - Oral anti-CD3 antibody treatment ameliorates mHSP65-induced atherosclerosis C. Grundtman, Maja A. Buszko, H. Dietrich, G. Wick; Innsbruck, Austria 490 P5.08.09 - Study of endothelial progenitor cells as a non-invasive strategy to detect endothelial alterations in patients with idiopathic thromboembolism Francesca Calcaterra, S. Rambaldini, C. Lodigiani, D. Mavilio, S. Della Bella; Rozzano, Italy 491 P5.08.10 - A murine model of atherosclerosis, frequency and phenotype of the B cell subsets involved Diana Castaño, H. Rincón-Arévalo, J. Villa-Pulgarín, J.R. Ramírez-Pineda, G. Vásquez, L.M. Yassín; Medellin, Colombia 492 P5.08.11 - Specific oligoclonal T-cell recruitment within epicardial adipose tissue of patients with acute coronary syndrome: evidence for a local, immune-mediated, pathogenetic mechanism Gabriele Di Sante, G. Liuzzo, A. Severino, V. Pazzano, D. Pedicino, S. Tziopulos, N. Luciani, F. Glieca, F. Ria, F. Crea; Rome, Italy 493 P5.08.12 - Kinins promote aortic aneurysm through stimulation of neutrophil activation via the B2 receptor Tammy Dougan, C.S. Moran, C. Rush, R. Jose, L. Woodward, J. Golledge; Townsville, Australia 494 P5.08.13 - Increased levels of MDA-modified collagen type IV in symptomatic lesions - a possible marker of unstable lesions Pontus Dunér, H. Grufman, A. Edsfeldt, F. To, J. Nilsson, I. Goncalves, E. Bengtsson; Malmö, Sweden 108 Posters - August 23 495 P5.08.14 - Myd88 signalling in CD4+ T cells promotes atherosclerosis and Th17 responses Daniel Engelbertsen, M. Wigren, H. Björkbacka, J. Nilsson, E. Bengtsson; Malmö, Sweden 496 P5.08.15 - Loss of B-cell function in MRas- knock-out mouse and reduced macrophage infiltration in atherosclerotic plaques at the aortic root Jennifer Freyer, M. Behrensen, Z. Aherrahrou, J.F.P. Berbèe, H. Schunkert, J. Erdmann; Lübeck, Germany 497 P5.08.16 - Human carotid atherosclerotic plaques with high Interleukin 16 mRNA levels are associated with less clinical symptoms Caitríona Grönberg, M. Nitulescu, L. Hollender, A. Persson, M. Nilsson, G. Nordin Fredrikson, J. Nilsson, H. Björkacka; Malmö, Sweden 498 P5.08.18 - IgE and eosinophilia levels in peripheral blood of patients with cardiovascular disease Morteza Hosseinzadeh, A. Khosravi, A. Delpisheh, S. Safari, R. Kafashi; Tehran, Iran, Islamic Republic of 499 P5.08.19 - Immunotherapy with tolerogenic Apolipoprotein B-100-loaded dendritic cells inhibits progression of atherosclerosis in hypercholesterolemic mice Daniel K. Johansson, D. Ketelhuth, A. Hermansson, M. Josefa Forteza de los Reyes, A. Ismail, K. Lindner, G.K. Hansson; Stockholm, Sweden 500 P5.08.20 - Apolipoprotein B100 danger-associated signal 1 (ApoBDS-1) is a potent platelet agonist that triggers procoagulant and proinflammatory responses A. Assinger, Y. Wang, L.M. Butler, G.K. Hansson, Z. Yan, C. Söderberg-Nauclér, Daniel F.J. Ketelhuth; Stockholm, Sweden 501 P5.08.21 - Study the correlation of haptoglobin phenotypes in acute heart attack patients Hossein A. Khazaei; Zahedan, Iran, Islamic Republic of 502 P5.08.22 - Sublingual vaccination with Porphyromonas gingivalis GroEL elicits protective immunity against atherosclerosis M. Hagiwara, Tomoko Kurita-Ochiai, R. Kobayashi, T. Hashizume-Takizawa, M. Yamamoto; Matsudo, Chiba, Japan 503 P5.08.23 - IL-25 treatment inhibits atherosclerosis development in ApoE deficient mice Polyxeni T. Mantani, P. Dunér, E. Bengtsson, R. Alm, I. Söderberg, L. Sundius, F. To, J. Nilsson, H. Björkbacka, G. Nordin Fredrikson; Malmö, Sweden 504 P5.08.24 - Soluble Fc RIIIaMφ levels in plasma correlate with stenosis rate in patients examined with carotid ultrasonography Midori Masuda, K. Kouno, N. Nishimura, H. Masaki, T. Yokoi, Y. Komiyama, T. Iwasaka, H. Takahashi; Osaka, Japan 505 P5.08.25 - Atherosclerosis in rats after immunization with human native low-density lipoproteins Igor Menshikov, K. Fomina, L. Beduleva; Izhevsk, Russian Federation 506 P5.08.26 - Susceptibility to ischemic stroke and HPA4/Annexin5 polymorphisms Imen Mezni, M. Jeljeli, T. Dhaouadi, S. Younes, N. Benali, I. Bannour, I. Sfar, A. Boughammoura, A. Bahloul, M. Makhlouf; Tunis, Tunisia 507 P5.08.27 - Inhibition of IL-27 attenuates atherosclerosis by inducing regulatory T cells Ornelia H. Ramos, P.J. van Santbrink, I. Bot, M. Bot, R. van der Sluis, M. ter Borg, S.C. de Jager, J. Kuiper; Leiden, Netherlands 508 P5.08.28 - Splenectomy increases atherosclerotic lesions in apolipoprotein E deficient mice Alice B. Rezende, N.N. Neto, L.R. Fernandes, A.C. Ribeiro, J.I. Alvarez-Leite, H.C. Teixeira; Juiz de Fora, Brazil 509 P5.08.29 - IL-22 deficiency induces vascular remodeling and alterations in immune cell populations after carotid injury Sara Rattik, G. Roos, I. Söderberg, H. Björkbacka, G. Nordin-Fredrikson, A. Hultgårdh-Nilsson, J. Nilsson; Malmö, Sweden 510 P5.08.30 - The role of anti-apolipoprotein A1 autoantibodies in cardiovascular risk stratification Priscila C. Teixeira, P. Ferber, A. Ducret, S. Pagano, H. Gaertner, O. Hartley, H. Langen, N. Vuilleumier, P. Cutler; Basel, Switzerland 511 P5.08.31 - Platelet-derived microparticles may contribute to the thrombotic tendency in systemic lupus erythematosus by both procoagulant and immune-mediated mechanisms Konstantinos Tselios, P. Klonizakis, S. Gerou, D. Bougiouklis, A. Sarantopoulos, I. Gkougkourelas, P. Boura; Thessaloniki, Greece 512 P5.08.32 - GDF-15, ST-2 and Galectin-3 plasma levels and their potential relations in patients with coronary artery disease Elena Vianello, G. Dogliotti, E. Dozio, M.M. Corsi Romanelli; Milan, Italy 513 P5.08.33 - Aggravation of atherosclerosis by MHC class II antigen deficiency is associated with a loss of regulatory T cells but is independent on IL-10 Maria Wigren, S. Rattik, H. Björkbacka, G. Nordin Fredrikson, J. Nilsson; Malmö, Sweden 109 Posters - August 23 P5.12 RHEUMATOID ARTHRITIS AND OTHER INFLAMMATORY JOINT DISEASES Session Time: Friday, August 23, 13:20 -15:00 514 P5.12.01 - The investigation of Anti Centromer Antibodies in Autoimmune Diseases B. Karaayak Uzun, A. Sener, E. Tarhan, Ilhan Afsar, S. Kaya; Izmir, Turkey 515 P5.12.02 - Oxidative stress or NK cells: The combination is getting deadlier for rheumatoid arthritis Ashish Aggarwal, A. Sharma, A. Bhatnagar; Chandigarh, India 516 P5.12.03 - B-cell activating factor versus biopsy in lupus nephritis among Egyptians systemic lupus patients Shereen Algergawy, E. Abd Algwad, r. zakaria; Benha, Egypt 517 P5.12.05 - Anti-Interleukin-6 and anti-TNF-alpha treatment do not have a negative impact on the immune response against CMV, but disease status influences the balance and the cytokine profile in juvenile idiopathic arthritis patients (JIA) Giovanni Almanzar, R. Trippen, K. Sustal, K. Höfner, M. Prelog; Würzburg, Germany 518 P5.12.06 - IL-1β membrane-bound receptors in health and in rheumatoid arthritis Alina Alshevskaya, F. Vasiliev, J. Lopatnikova, N. Shkaruba, O. Chumasova, A. Sizikov, S. Sennikov; Novosibirsk, Russian Federation 519 P5.12.08 - Performance of anti-CCP3 IgG/IgA (CCP3.1) test compared to anti-CCP2 IgG test Mounira Benidir, H. Amroun, S.S. Salah, G. Hamadi, O. Rendja, N. Attal, M.C. Abbadi; Algiers, Algeria 520 P5.12.09 - Rheumatoid arthritis: early thymic involution or increased proliferation rate? Elena A. Blinova, V.S. Kozhevnikov, A.E. Sizikov, V.A. Kozlov; Novosibirsk, Russian Federation 521 P5.12.10 - TNF receptor function is dispensable for generation of CD23+ CD21-high B cells in inflamed nodes I. Kuzin, E. Schwarz, Andrea Bottaro; Camden, United States 522 P5.12.11 - Biomarker of inflammation in juvenile idiopathic Arthritis (JIA) Juergen Brunner, T. Giner, G. Weiss, D. Fuchs; Innsbruck, Austria 523 P5.12.12 - APRIL, a TNF family member, can be a predictor of resistance to antigen-induced arthritis in mice Adriana Carvalho, R. Vasconcellos, C.E.C. Pinto, M. Hahne, W. Savino, D.M.S. Villa-Verde; Rio de Janero, Brazil 524 P5.12.13 - Optimization of “in vitro” culture conditions for human arthritis rheumatoid synovial fibroblasts Claudia Casnici, D. Lattuada, K. Crotta, O. Marelli; Milan, Italy 525 P5.12.14 - S100A8 plays an anti-inflammatory role in collagen-induced arthritis Annabelle Cesaro, N. Pagé, M.R. Tardif, A. Al-Shami, T. Oravecz, P.A. Tessier; Quebec, Canada 526 P5.12.15 - ERAP1 gene polymorphisms influence the risk of Spondyloarthritis in HLA-B27 positive Romanians M. Cherciu, L.O. Popa, M. Bojinca, M.I. Dutescu, V. Bojinca, R. Caisan, C. Bara, Olivia M. Popa; Bucharest, Romania 527 P5.12.16 - TWEAK Promotes Osteoclastogenesis in Rheumatoid Arthritis Mi-La Cho, J. Park, M. Lim, S. Kwok, J. Jhun, S. Park; Seoul, Korea, Republic of 528 P5.12.17 - CD8+ T cell reactivity against apoptotic self-epitopes in rheumatoid arthritis patients treated with etanercept Alessandra Citro, R. Scrivo, H. Martini, S. Piconese, F. Miranda, V. Barnaba, G. Valesini; Rome, Italy 529 P5.12.18 - The effect of the Slc11a1 gene on pristane-induced arthritis chronic phase Mara A. Correa, T. Canhamero, J.L. Guerra, A. Borrego, J.R. Jensen, W.H. Cabrera, N. Starobinas, O.G. Ribeiro, O.C. Ibanez, M. De Franco; São Paulo, Brazil 530 P5.12.19 - Role of the expression CCR7+CCR5+ CX3CR1+ CD95 +/- in the peripheral blood lymphocytes in systemic lupus erythematous patients Laila A. Damiati, A.M. Al-Dahlawi, M.F. El-Shal, S.M. Bahlas; Jeddah, Saudi Arabia 531 P5.12.20 - Role of CCRL2 in the pathogenesis of mouse experimental arthritis Annalisa Del Prete, S. Gonzalvo-Feo, L. Wang, C. Mazzon, E. Scanziani, A. Vecchi, S. Sozzani; Rozzano (MI), Italy 532 P5.12.21 - Collagen-specific TCR Repertoire usage in RA and cytokine secretion Gabriele Di Sante, A. Fedele, B. Tolusso, C. Nicolò, A. Carbonella, S. Bosello, E. Gremese, S. Canestri, F. Ria, G. Ferraccioli; Rome, Italy 533 P5.12.22 - Clinical and immunological characteristics of Senegalese patients with rheumatoid arthritis (RA)diagnosed according to American College of Rhumatology criteria of 1987 Mamadou L. Diokh, M. Sylla Niang, B. Mbengue, A.C. Ndao Mbengue, F. Sow Faye, S. Ndongo, T.N. Dièye, A. Dièye; Dakar, Senegal 110 Posters - August 23 534 P5.12.23 - T676G polymorphims of the TNF receptor type II is associated with ankylosing spondylitis Ma D.J. Durán-Avelar, J. Gutiérrez-Franco, N. Vibanco-Pérez, F.D. Trejo-Ramírez, S. Peña-Virgen, J.F. Zambrano-Zaragoza; Tepic, Mexico 535 P5.12.24 - Cytokines in relation to autoantibodies before onset of symptoms in systemic lupus erythematosus (SLE) Catharina Eriksson, S. Rantapää Dahlqvist; Umeå, Sweden 536 P5.12.25 - Identification of myeloid dendritic cells and plasmacytoid dendritic cells in the peripheral blood of rheumatoid arthritis Svetlana A. Falaleeva, V. Kurilin, N. Shkaruba, O. Chumasova, A. Sizikov, S. Sennikov; Novosibirsk, Russian Federation 537 P5.12.26 - Extended characterization of human chondrocytes for establishment of co-culture systems with synovial fibroblasts under different culture conditions in the context of Rheumatoid Arthritis S. Möller, P. Kern, H. Joos, R. Brenner, Jens A.A. Fischer; Penzberg, Germany 538 P5.12.27 - Interplay of myeloid cells and synovial fibroblast boosts the inflammatory response P. Kern, B. Schwarz, M. Galm, L. Pradel, Jens A.A. Fischer; Penzberg, Germany 539 P5.12.28 - The candidate rheumatoid arthritis autoantigen aggrecan enhance IL-9 response in peripheral blood of Rheumatoid Arthritis’ patients Giuseppina Giardina; Palermo, Italy 540 P5.12.29 - Certolizumab Pegol in Rheumatoid Arthritis. Follow-up in latinoamerican experience Renato Antonio Guzman Moreno, G. Roa Montes, J. Cordoba, W. Rodriguez, W. Otero; Bogota, Colombia 541 P5.12.30 - Chondrocytes as mediators of citrullination and humoral immunity to citrullinated type II collagen in Rheumatoid Arthritis Sabrina Haag, N. Schneider, D.E. Mason, J. Tuncel, I.E. Andersson, E.C. Peters, H. Burkhardt, R. Holmdahl; Stockholm, Sweden 542 P5.12.31 - TNF-alpha and IL1-beta contribute to the increased severity of serum-induced arthritis in NOX2 deficient mice Ya-Fang Huang, P.A. Nigrovic, C. Shieh; Tainan, Taiwan 543 P5.12.32 - TNFα-induced adipose-related protein (TIARP) functions as a negative regulator of inflammatory process in arthritis Asuka Inoue, I. Matsumoto, N. Umeda, Y. Tanaka, C. Takai, S. Takahashi, T. Sumida; Tsukuba, Ibaraki, Japan 544 P5.12.33 - Increase of PADI4 in the joints and anti-CCP antibody in the sera of a murine model for rheumatoid arthritis before the clinical onset of arthritis Katsuhiko Ishihara, A. Yahagi, T. Saika, H. Igarashi; Kurashiki, Japan 545 P5.12.34 - Promoter polymorphisms of the TNFα (-308 G/A) and IL-6 (-174G/C) genes predict therapeutic response to etanercept Ivan R. Jancic, N. Arsenovic -Ranin, M. Sefik-Bukilica, S. Zivojinovic , N. Damjanov, V. Spasovski, S. Srzenti , B. Stankovic, S. Pavlovic ; Belgrade, Serbia 546 P5.12.36 - Dendritic Cell ImmunoReceptor (DCIR) is a negative regulator in balancing bone metabolism Tomonori Kaifu, T. Maruhashi, G. Ma, R. Yabe, A. Seno, Y. Iwakura; Noda, Japan 547 P5.12.37 - Immunomodulatory role of Fasiola gigantica derived somatic antigens Yasir A. Khan, S. Umar, M.A.H. Khan, P.A.A. Shareef, R. Ullah, A. Rehman, S.M.A. Abidi; Aligarh, India 548 P5.12.38 - Fibrinogen induced inhibition of osteoclastogenesis is reversed by citrullination of fibrinogen by peptidylarginine deiminase Ji S. Kim, M.K. Choi, J.Y. Choi, J.Y. Kim, J.S. Song, H.J. Kim, K.H. Park-Min, L.B. Ivashkiv, Y.W. Song, E.Y. Lee; Seoul, Korea, Korea, Republic of 549 P5.12.39 - Caspase-5 inhibition suppresses inflammatory responses in fibroblast-like synoviocytes with rheumatoid arthritis Yong-Jin Kwon, J. Song, Y. Park, S. Lee, M. Park; Seoul, Korea, Republic of 550 P5.12.40 - Significant reduction of the Cia25/Pia42 interval, a new arthritis severity and joint damage locus that regulates the invasive properties of synovial fibroblasts. Cia25/Pia42 M. Brenner, Teresina Laragione, P.S. Gulko; Manhasset, United States 551 P5.12.41 - The arthritis severity locus Cia4 is an early regulator of IL-6, IL-1b and genes implicated in NFkB activation in synovial tissues of rats with pristane-induced arthritis M. Brenner, Teresina Laragione, P.S. Gulko; Manhasset, United States 552 P5.12.43 - TRPV2 is new suppressor of arthritis severity and joint damage Teresina Laragione, C. Beeton, P.S. Gulko; Manhasset, United States 111 Posters - August 23 553 P5.12.42 - The nuclear receptor NR1D1 suppresses the invasive properties of synovial fibroblasts from rheumatoid arthritis Teresina Laragione, M. Brenner, P.S. Gulko; Manhasset, United States 554 P5.12.44 - Decreased heart rate variability in patients with Behcet’s disease JoungWook Lee; Busan, Korea, Republic of 555 P5.12.46 - Antibodies against TIF1gamma in cancer associated myositis precede cancer symptoms and persist after cancer removal Ingrid E. Lundberg, L. Dani, M. Dastmalchi, N. Martínez, M. Labrador-Horrillo, A. Selva O’Callaghan; Stockholm, Sweden 556 P5.12.47 - Anti-Saccharomyces cerevisiae antibodies in rheumatoid arthritis patients W. Sakly, A. Mankai, W. Manoubi, Ibtsem Ghedira; Tunis, Tunisia 557 P5.12.48 - Anti-Saccharomyces cerevisiae antibodies in patients with systemic lupus erythematosus A. Mankai, W. Sakly, Y. Thabet, A. Achour, W. Manoubi, Ibtsem Ghedira; Tunis, Tunisia 558 P5.12.49 - MiRNA expression profile of peripheral blood mononuclear cells from RA patients and their relationship with anti-TNF therapy Pier Luigi Meroni, M. Raimondo, M. Borghi, M. Mirolo, F. Pregnolato, F. Ambrogi, E. Biganzoli, M. Locati; Milan, Italy 559 P5.12.50 - Podoplanin is upregulated at the Th17-mediated inflammation in SKG arthritic mice Yoshiaki Miyamoto, H. Uga, M. Kadowaki, M. Ikeda, H. Kurata; Kobe, Japan 560 P5.12.51 - Allelic expression of 89G/A, 90T/C and 92G/C PADI4 polymorphisms in rheumatoid arthritis Salvador Muñoz-Barrios, L.I. Angel-Chávez, C.A. Palafox-Sánchez, E. Oregón-Romero, I. Parra-Rojas, Z. Reyes-Castillo, M. Vázquez-Villamar, J.F. Muñoz-Valle; Guadalajara, Jalisco, Mexico 561 P5.12.52 - Evaluation of anti-PADI4 antibodies in rheumatoid arthritis: Association with clinical parameters Salvador Muñoz-Barrios, Z. Reyes-Castillo, M. Vázquez-Villamar, C.A. Palafox-Sánchez, E. Oregón-Romero, I. Parra-Rojas, L.I. Angel-Chávez, M.O. Guzmán-Ornelas, R.E. Navarro-Hernández, J.F. Muñoz-Valle; Guadalajara, Jalisco, Mexico 562 P5.12.53 - Study of IGA1 O-Glycosylation in a multi-ethnic population of IGA Nephropathy patients in Kwazulu Natal, South Africa Prishani Nansook, A.G. Assounga; Durban, South Africa 563 P5.12.54 - The mesenchymal stem cell supernatant therapy improves symptoms of collagen-induced arthritis in rats Maryam Nezafat Firizi, T. Mousavi, E. Entezami; Tehran, Iran, Islamic Republic of 564 P5.12.55 - A monoclonal CCP-antibody derived from RA patients binds to several citrullinated antigens in the human cellular components Tatsuhiko Ozawa, R. Tuda, E. Kobayashi, H. Hounoki, K. Shinoda, H. Taki, K. Tobe, H. Kishi, A. Muraguchi; Toyama, Japan 565 P5.12.56 - Complement Regulatory Protein MCP; CD46 in Rheumatoid Arthritis Roma Pahwa, U. Kumar, N. Das; New Delhi, India 566 P5.12.57 - Halofuginone ameliorates autoimmune arthritis by regulation the balance between Th17 and Tregs and the inhibition of osteoclastogenesis Sung-Hwan Park, M. Park, E. Park, D. Lee, S. Baek, E. Yang, J. Woo, S. Kwok, H. Kim, M. Cho; Seoul, Korea, Republic of 567 P5.12.58 - Number of activated cytotoxic T-lymphocytes and natural killers in children with juvenile arthritis. Irina A. Pashnina; Ekaterinburg, Russian Federation 568 P5.12.59 - Antibodies to citrullinated peptide in children with juvenile arthritis Irina A. Pashnina, I.M. Krivolapova; Ekaterinburg, Russian Federation 569 P5.12.60 - The number of B-cells subpopulations and level of autoantibodies in children with juvenile arthritis Irina A. Pashnina, I.M. Krivolapova; Ekaterinburg, Russian Federation 570 P5.12.61 - IL12B gene haplotype influences the risk of ankylosing spondylitis in Romanians Olivia Mihaela Popa, E. Kriegova, L. Popa, M. Cherciu, M.I. Dutescu, M. Bojinca, V. Bojinca, P. Schneiderova, C. Bara, M. Petrek; Bucharest, Romania 571 P5.12.63 - Angiogenic T cell depletion in Rheumatoid Arthritis patients Javier Rodriguez-Carrio, M. Alperi-López, P. López, S. Alonso-Castro, F.J. Ballina-García, A. Suárez; Oviedo, Spain 572 P5.12.64 - The +1858C>T/-1123G>C PTPN22 gen haplotypes and linkage disequilibrium in rheumatoid arthritis patients from Western Mexico Yeniley Ruiz-Noa, J.R. Padilla-Gutierrez, C.A. Palafox-Sánchez, Y. Valle, E. Oregón-Romero, G.E. Martínez-Bonilla, J.F. Muñoz-Valle; Guadalajara, Jalisco, Mexico 112 Posters - August 23 573 P5.12.65 - Anti-TNF treatment limits the prothrombotic features of platelets and neutrophils in rheumatoid arthritis M. Baldini, N. Maugeri, P. Rovere-Querini, E. Baldissera, G. Peretti, Maria G. Sabbadini, A.A. Manfredi; Milan, Italy 574 P5.12.66 - Comparative significance of YKL-40 in different types of arthritis M. Kazakova, A. Batalov, N. Mateva, Z. Kolarov, Victoria Sarafian; Plovdiv, Bulgaria 575 P5.12.67 - A positive feedback mechanism of IL-6 through phosphorylated and unphosphorylated STAT3 in inflammatory arthritis Mamdouh A.K. Sedhom, A.G. Pratt, A. Anderson, C. Routledge, J. Chay, J. Isaacs, R. Thomas; Woolloongabba, QLD, Australia 576 P5.12.68 - Anti-mutated citrullinated vimentin antibodies of IgA isotype during rheumatoid arthritis H. Ben Hassine, O. Khalifa, H. Ben Fraj, H. Zaglaoui, E. Bouajina, Rim Sghiri; Sousse, Tunisia 577 P5.12.69 - Genetic susceptibility to rheumatoid arthritis in the Tunisian population: case of PADI4 and REL genes H. Ben Hassine, R. Zemni, O. Khalifa, H. Zaglaoui, E. Bouajina, F. Slama, J. Boukadida, Rim Sghiri; Sousse, Tunisia 578 P5.12.07 - Anti-C1q antibodies and systemic lupus erythematosus in the Tunisian population Hana Ben Hassine, B. Trad, M. Khalifa, N. Idriss, F. Slama, J. Boukadida, R. Sghiri; Sousse, Tunisia 579 P5.12.70 - The development of antibodies specific for carbamylated protein precedes disease onset in mice with collagen induced arthritis Jeroen N. Stoop, B. Liu, J. Shi, D.T.S.L. Jansen, T.W.J. Huizinga, L.A. Trouw, R.E.M. Toes; Leiden, Netherlands 580 P5.12.71 - Aryl hydrocarbon receptor genetic polymorphisms are associated with Rheumatoid Arthritis Jhimmy Talbot, R.S. Peres, R.D.R. Oliveira, J.R. Silva, B. Ryffel, T.M. Cunha, J.C. Alves-Filho, E.Y. Liew, P. Louzada-Junior, F.Q. Cunha; Ribeirao Preto, Brazil 581 P5.12.72 - Premolis semirufa caterpillar-bristles toxic components induce intense cellular and humoral immune responses I.M. Villas-Boas, R.M. Gonçalves de Andrade, C.C. Squaiella-Baptistão, O.A. Sant’Anna, Denise V. Tambourgi; São Paulo, Brazil 582 P5.12.73 - Association of the 22 genotype of enhancer HS1,2A of the Ig heavy 3 regulatory region (IgH3 RR-1) with non response to DMARDS and response to Rituximab in rheumatoid arthritis patients Barbara Tolusso, E. Gremese, A. Fedele, E. Serone, D. Frezza, M. Gigante, M. Nowik, S. Canestri, C. Di Mario, G. Ferraccioli; Rome, Italy 583 P5.12.74 - TRAF-6 dependent signaling pathway is essential for TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation Hwei-Fang Tsai, H. Liao, P. Hsu; Taipei, Taiwan 584 P5.12.75 - Prevalence of hyperprolactinaemia in antiphospholipid syndrome Christina Tsigalou, T.G. Konstantinidis, E. Konstantinidou, T. Gioka, N. Galanopoulos, A. Tsirogianni, G. Kampouromiti; Alexandroupolis, Greece 585 P5.12.76 - Deficiency of prostaglandin D2 receptor CRTH2 deteriorates adjuvant-induced arthritis Yoshiki Tsubosaka, S. Matsumoto, H. Hirai, M. Hori, M. Nakamura, H. Ozaki, T. Murata; Bunkyo-ku, Tokyo, Japan 586 P5.12.77 - Association of PD1.1 and PD1.6 polymorphisms with ankylosing spondylitis Norberto Vibanco-Pérez, J. Gutiérrez-Franco, M.D.J. Durán-Avelar, J.M. Agraz-Cirbian, M.A. Jiménez-Alvarez, S. Peña-Virgen, J.F. Zambrano-Zaragoza; Tepic, Mexico 587 P5.12.78 - IL-6R blockade enhances CD39+ efficient regulatory T cells in Rheumatoid Arthritis Patients Rita Vicente, Y. Pers, P. Portales, J. Quentin, J. Eliaou, C. Jorgensen, P. Louis-Plence; Montpellier, France 588 P5.12.79 - Prediction rheumatoid arthritis outcome in patients with unclassified arthritis considering enzymatic serum activity Marharyta Volkava, A. Kundzer; Vitebsk, Belarus 589 P5.12.80 - Nuclease IgG activity toward different DNA substrates in patients with rheumatoid arthritis Marharyta Volkava, A. Kundzer, I. Generalov; Vitebsk, Belarus 590 P5.12.81 - Reactive arthritis of Yersinia etiology: diagnostics and immunological analysis Olga P. Vostrikova, O. Portnyagina, A. Dubikov, O.D. Novikova; Vladivostok, Russian Federation 591 P5.12.82 - The protective role of intracellular reactive oxygen species in autoimmune arthritis Susann Winter, F. Laulund, M. Hultqvist, R. Holmdahl; Stockholm, Sweden 592 P5.12.84 - Association of the +49-A/G polymorphism of CTLA-4 in mexican patients with ankylosing spondylitis Jose F. Zambrano-Zaragoza, J. Gutiérrez-Franco, M.D.J. Durán-Avelar, B.V. de León-Amaral, S. Peña-Virgen, N. Vibanco-Pérez; Tepic, Mexico 113 Posters - August 23 593 P5.12.85 - Implication for the detection of the joint lesion associated factors and EBV infection in patients with rheumatoid arthritis Dong Q. Zhang, X. Chen, R. Xu; Shanghai, China 594 P5.12.86 - A CD19/CD3 bispecific TandAb, AFM11, facilitates safe and potent killing of CD19+ cells mediated by T-cells Eugene Zhukovsky, U. Reusch, C. Burkhardt, S. Knackmuss, M. Eser, I. Fucek, K. Ellwanger, F. McAleese, M. Little; Heidelberg, Germany P5.17 AUTOINFLAMMATORY DISEASES Session Time: Friday, August 23, 13:20 -15:00 595 P5.17.01 - The proliferative response to PHA and SEB stimulation of peripheral blood mononuclear cells from oral lichen planus patients Tatiana F.A. Almeida, A.M. Mesquita, G.E.B. Alvim-Melo, E. Rocha-Vieira; Diamantina, Brazil 596 P5.17.03 - Endogenous IFN-γ prevents escalation of normal immunity into a Th17-driven inflammation reminiscent of systemic juvenile idiopathic arthritis Anneleen Avau, T. Mitera, S. Put, K. Put, E. Brisse, A. Liston, G. Leclercq, A.D. Billiau, C.H. Wouters, P. Matthys; Leuven, Belgium 597 P5.17.04 - Risk factors of asthma in preschool children L. Aghebati Maleki, Behzad Baradaran, j. Majidi, A. Aghebati Maleki, F. Zare Shahneh, F. Zamani; Tabriz, Iran, Islamic Republic of 598 P5.17.05 - Pertussis toxin- driven IL-1β production is required for highly encephalitogenic GM-CSF+ T cell generation in EAE pathogenesis Camilla Basso, F. Ronchi, S. Preite, A. Reboldi, A. Lanzavecchia, F. Sallusto; Bellinzona, Switzerland 599 P5.17.06 - Expression of Suppressor of Cytokine Signalling (SOCS) 1 and 3 in Behçet’s Disease Lesley A. Bergmeier, M. Hamedi, E. Hagi-Pavli, G. Warnes, F. Fortune; London, United Kingdom 600 P5.17.07 - Analysis of neutrophil function in severe and moderately affected Chronic Fatigue Syndrome subjects S.L. Hardcastle, Ekua W. Brenu, D. Staines, S. Marshall-Gradisnik; Gold Coast, Australia 601 P5.17.08 - To investigate the roles of IL-12 family cytokines on islet graft rejection and tolerance Heng Yi Chen, F. Chou, H. Sytwu; Taipei, Taiwan 602 P5.17.09 - Characterization of tonsil infiltration and gene expression profile of innate sensors in PFAPA Syndrome Sabrina Chiesa, R. Caorsi, F. Penco, A. Bertoni, S. Borghini, A. Omenetti, A. Sementa, F. Bellora, A. Martini, M. Gattorno; Genova, Italy 603 P5.17.10 - Autoantibodies characteristics of patients with autoimmune liver disease in Uygur people Luo De Mei, Z. Jian Mei, S. Gulinaer; Urumqi, China 604 P5.17.11 - BAFF, κ and λ free light chains, C4d and IgG in serum and relations with peripheral blood lymphocyte populations in patients with primary Sjögren’s syndrome Irena Dumalakiene, A. Siaurys, D. Mieliauskaite, I. Butrimiene, D. Characiejus, M. Mauricas, G. Sudzius; Vilnius, Lithuania 605 P5.17.12 - Antinuclear antibodies without identified antigenic target: what is their diagnostic value? Sawsan Feki, F. Frikha, Y. Ben Haj Hmida, M. Ben Ayed, O. Abida, Z. Bahloul, H. Masmoudi; Sfax, Tunisia 606 P5.17.13 - Cyclophosfamide plus Rituximab treatment in a case of plurirefractory cutaneous sarcoidosis with large vessels vasculitis Valeria Ferri, N. Compagno, R. Scarpa, M. Gazzola, P. Tartaro, C. Agostini; Padova, Italy 607 P5.17.14 - CD8+ T cells in the pathogenesis of Systemic Sclerosis Patrizia Fuschiotti, A. Larregina, J. Ho, C. Feghali-Bostwick, T. Medsger Jr.; Pittsburgh, United States 608 P5.17.15 - Anti-BPI (bactericidal permeability increasing) in autoimmune vasculitis Sabiha N. Gadiri, H. Meriche, S. Brougui, A. Guermaz, M. Abbadi; Annaba, Algeria 609 P5.17.16 - Association of enhanced Tim-3 expression on monocytes with disease activity in systemic lupus erythematosus B. Liu, X. Liang, C. Ma, Lifen Gao; Jinan, China 610 P5.17.17 - Effects of Vitamin D on regulatory T cells in lupus patients Mohsen Ghoryani, H. Reihani, M. Rastin, M. Mahmoudi, M. Sahebari, F. Lavi, F. Faraji, N. Tabasi, S. Zamani, M. Khazaee; Mashhad, Iran, Islamic Republic of 611 P5.17.18 - Oral changes in Wegener granulomatosis(WG) Josipa Sanja Gruden Pokupec; Zagreb, Croatia 114 Posters - August 23 612 P5.17.20 - Dense fine speckled patterned antinuclear antibody in patients with fibromyalgia Hyun-Sook Kim; Seoul, Korea, Republic of 613 P5.17.21 - Expression and function of the NLRP3 inflammasome in Behçet’s disease En Hyung Kim; Seoul, Korea, Republic of 614 P5.17.22 - The cytokine production of peripheral blood mononuclear cells reflects the autoantibody profile of patients suffering from type 1 diabetes Jana Labiková, J. Vceláková, S. Kolousková, K. Stechová; Prague, Czech Republic 615 P5.17.24 - Accelerated spontaneous apoptosis of neutrophils in patients with familial Mediterranean fever Gayane Manukyan, A. Martirosyan, G. Hagobyan, R. Aminov, T. Davtyan; Yerevan, Armenia 616 P5.17.26 - The prevalence of wheezing and its relationship with some environmental factors in children aged 6-7 in Yazd Mojtaba Mirzaei, M. Mirzaei; Tehran, Iran, Islamic Republic of 617 P5.17.27 - Psychoneuroimmunologycal study in Cuban in patients with systemic lupus erythematosus E. Noris- Garcia, M. Lánigan, N. Diaz, I. Corrales, A. Brito, N. Fresneda, D. Barberia, R. Rodríguez, S. Arce, Giselle Penton Rol; La Havana, Cuba 618 P5.17.28 - CAPS monocytes are highly susceptible to oxidative stress: effects on cytokine secretion, reversal by antioxidants Patrizia Piccioli, S. Carta, L. Delfino, F. Penco, A. Martini, M. Gattorno, A. Rubartelli; Genoa, Italy 619 P5.17.29 - Loci associated with N-glycosylation of human IgG show pleiotropy with autoimmune diseases and haematological cancers Maja Pucic Bakovic, G. Lauc, J. Huffman, J. Wilson, M. Wuhrer, A. Wright, P. Rudd, C. Hayward, H. Campbell, I. Rudan; Zagreb, Croatia 620 P5.17.30 - B-cell depletion in neuropsychiatric disease in MRL/lpr mice Chaim Putterman; Bronx, United States 621 P5.17.31 - Induction of immunoglobulin G Fc-sialylation is associated with disease remission in CIDP Isaak Quast, F. Cueni, M.A. Maurer, F. Nimmerjahn, M. Dalakas, J.D. Lünemann; Zürich, Switzerland 622 P5.17.33 - Antibody profile and their relationship with clinical manifestations in patients with Systemic Lupus Erythematosus Maryam Rastin, M. Mahmoudi, N. Tabasi, S. Zamani, M. Khazaee, M. Ghoriani, H. Reihani, F. Faraji, F. Lavi; Mashhad, Iran, Islamic Republic of 623 P5.17.34 - 1,25 Dihydroxy vitamin D modulatory effects in patients with systemic lupus erythematosus Maryam Rastin, M. Mahmoudi, M. Sahebari, N. Tabasi, S. Zamani, D. Haghmorad, R. Nosratabadi; Mashhad, Iran, Islamic Republic of 624 P5.17.35 - Effects of Vit D on Th17 cells and related cytokines in lupus erythematosus patients Hadi Reihani, M. ghoryani, M. Rastin, M. Mahmoudi, M. Sahebari, R. Nosratabadi, F. Faraji, F. Lavi, N. Tabasi, S. Zamani; Mashhad, Iran, Islamic Republic of 625 P5.17.36 - Disease modeling and drug discovery using induced pluripotent stem cells from CINCA syndrome patients Megumu Saito; Kyoto, Japan 626 P5.17.37 - Distribution of peripheral blood lymphocyte populations in patients with primary Sjögren’s syndrome Gintaras Sudzius, D. Characiejus, D. Mieliauskaite, A. Siaurys, I. Butrimiene, I. Dumalakiene; Vilnius, Lithuania 627 P5.17.38 - Protease activation receptors - A new link between IgE mediated and non-IgE mediated inflammatory reactions Shanshan Sun, G. Mackay, A. Lopata; Townsville, Australia 628 P5.17.39 - Identification of a novel cold-associated autoantigen, heterogeneous nuclear RNP-K, in patients with secondary Raynaud’s phenomenon by proteomic approach. Ohkawara Tomoharu, L. Yang, H. Honda, S. Serada, M. Fujimoto, T. Naka; Osaka, Japan 629 P5.17.40 - Increased levels of IL-17F but not IL-17A in patients with immunosuppressive therapy for autoimmune hepatitis (AIH). P. Thomas-Dupont, L.A. Sanchez-Vargas, I.Y. Izaguirre-Hernandez, M. Maldonado-Renteria, A. Torre-Delgadillo, J.M. Remes-Troche, E. Bravo-Sarmiento, Hector Vivanco-Cid; Veracruz, Veracruz, Mexico 630 P5.17.41 - Amplification of T cell autoreactivity by OX40/OX40L functional complex on peripheral CD4+ T cells in Graves’ disease and clinical significance Qin Wang, X. Zhang, Y. Ma, X. Zhang; Suzhou, China 631 P5.17.42 - Increased frequency of Th17 cells in patients with dermatomyositis X. Tang, J. Tian, J. Chen, Y. Liu, Shengjun Wang; Zhenjiang, China 115 Posters - August 23 632 P5.17.43 - Plasma microparticles and LL-37 levels regulate Behcet’s Disease severity T. Kahraman, Fuat Cem Yagci, I. Gursel; Ankara, Turkey 6.03 PATHOGENESIS AND IMMUNOINTERVENTION IN DIABETES Session Time: Friday, August 23, 13:20 -15:00 633 P6.03.01 - B-1 cells produce a insulin-like factor and regulate blood glucose levels in STZ-induced diabetic mice Anuska M. Alvares, M.C.T. Novo, J.T. Maricato, A. Popi, M. Mariano; São Paulo, Brazil 634 P6.03.02 - Regulation of inflammasome activation and its implication in diabetes-induced microangiopathies Babak Baban, F. Lamoke, L. Di Renzo, J. Liu, A. Alvari, M. Bartoli; Augusta, United States 635 P6.03.03 - Autoimmune Anti-prothrombin Antibodies in Type 1 Diabetes Mellitus Filiz Bakar, U. Ünlütürk, N. Ba kal, S. Nebio lu; Ankara, Turkey 636 P6.03.04 - Ursolic acid effect on proinflammatory cytokines in response to diet-induced obesity in rats Blanca E. Bastidas-Ramírez, A.S. González-Ballesteros, A. López-Vázquez, J.J. García-Bañuelos, A.S. Sandoval-Rodríguez, J.F. Muñoz-Valle, M.R. Bueno-Topete, S. Del Toro-Arreola, R. Del Angel-Meza, J.S. Armendáriz-Borunda; Guadalajara, Mexico 637 P6.03.06 - Differential expression of microRNAs in type 1, type 2 and gestational diabetes pinpointed miR-142-5p as potential biomarker for diabetes mellitus C.V.A. Collares, A.F. Evangelista, D.J. Xavier, D.M. Rassi, M.C. Foss-Freitas, M.C. Foss, E.T. Sakamoto-Hojo, G.A. Passos, Eduardo A. Donadi; RIbeirao Preto, Brazil 638 P6.03.07 - TCRγδ T cells in human type 1 diabetes: evidence or clue? Gian Maria Giamporcaro, A. Valle, A. Stabilini, M. Battaglia; Milan, Italy 639 P6.03.08 - Resistance of Diabetes in Aged NOD Mice is Mediated by CD4+CD25+Foxp3+ Regulatory T Cells Zhiguang Guo, B. Liu, L. Tian, B. Tian, A. Ansarullah, Y. Lu, M. Holstein, B. Deruyter; Sioux Falls, United States 640 P6.03.09 - The effect of induced hyperglycemia on the expression levels of TLR2 and TLR4 genes in the hippocampus of male Wistar rats during a time course induction of diabetes type 1 Alireza Haghparast, A. Dehghani Firoozabadi, S. Shojaei, M. Behnam Rasouli, N. Mahdavi Shahri; Mashhad, Iran, Islamic Republic of 641 P6.03.10 - Appearance of beta cell autoantigen primed CD4+ T cells is synchronous to circulating islet autoantibodies in early pre-type 1 diabetes Denise Kuehn, A. Heninger, C. Wilhelm, A. Eugster, S. Dietz, A.G. Ziegler, E. Bonifacio; Dresden, Germany 642 P6.03.11 - Relationship between BKCa channel and the apoptosis of NIT-1 cells induced by IFN-γ/IL-1β treatment T. Yu, J. He, S. Huang, H. Zhu, G. Shen, F. Gong, Ping Lei; Wuhan, China 643 P6.03.12 - Anti-inflammatory and anti-diabetic activities of the methanolic fraction of Centratherum anthelminticum seed in STZ-nicotinamide-induced type 2 diabetic rat Chung Yeng Looi, A. Arya, M. Mustafa; Kuala Lumpur, Malaysia 644 P6.03.13 - Can dietary intervention with whole grain decrease risk of type 2 diabetes by reducing inflammasome assembly and IL1β secretion by circulating human neutrophils? Rasmus B. Maerkedahl, S.B. Metzdorff, C.B. Nielsen, M. Stenbæk, R.J. Gøbel, M. Kristensen, L. Lauritzen, H. Frøkiær; Frederiksberg, Denmark 645 P6.03.14 - Carbon monoxide-releasing molecule CORM-A1 attenuates the development of autoimmune diabetes in mice induced by multiple low doses of streptozotocin Ivana Nikolic, T. Saksida, I. Stojanovic, F. Nicoletti, S. Stosic-Grujicic; Belgrade, Serbia 646 P6.03.15 - Activation of Natural Killer T Cells Promotes Th2 Immune Response in Adipose Tissue of Obese Galectin-3 Deficient Mice and Improves Systemic Glucose Homeostasis Jelena Pantic, N. Pejnovic, I. Jovanovic, G. Radosavljevic, G. Besra, N. Arsenijevic, M. Lukic; Kragujevac, Serbia 647 P6.03.16 - IL-2 and rapamycin in immunotherapy of type 1 diabetes: friends or foes? Louis Pérol, A. Baeyens, G. Fourcade, N. Cagnard, W. Carpentier, J. Woytschak, O. Boyman, A. Hartemann, E. Piaggio; PARIS, France 648 P6.03.17 - Treg CD39+ and Th17 cells in Type 2 Diabetes Mellitus Patients N. Cortez-Espinosa, S.E. Medellin-Garibay, J.D. Cortes-Garcia, A. Nuñez-Ruiz, R. González-Amaro, Diana P. Portales-Pérez; San Luis Potosí, Mexico 649 P6.03.18 - Immunohistochemical study of the pancreas of patients with long termed diabetes mellitus type 1 A. Proshchina, Yulia Krivova, V. Barabanov, S. Saveliev; Moscow, Russian Federation 116 Posters - August 23 650 P6.03.19 - ST2 deficiency enhances diet-induced inflammation in visceral adipose tissue and obesity in mice Gordana Radosavljevic, N. Pejnovic, J. Pantic, I. Jovanovic, I. Jeftic, N. Jovicic, N. Arsenijevic, M. Lukic; Kragujevac, Serbia 651 P6.03.20 - Oral administration of L. Lactis secreting hGAD65370-575 and hIL-10 can revert diabetes in recent-onset NOD mice when combined with low-dose anti-CD3 Sofie Robert, T. Takiishi, k. Van Huynegem, L. Steidler, H. Korf, C. Gysemans, T. Van Belle, P. Rottiers, C. Mathieu; Leuven, Belgium 652 P6.03.21 - Transfer of type 1 diabetes by bone marrow transplantation Eleonora Tresoldi, P. Monti, P. Piatti, B. Mfarrej, F. Onida, E. Bosi, M. Battaglia; Milan, Italy 653 P6.03.22 - Characterization of monoclonal ZnT8-specific antibody Julia Ustinova, D. Belitskin, E. Juronen, E. Zusinaite, M. Utt, R. Uibo; Tartu, Estonia 654 P6.03.23 - Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signaling in retinal endothelial cells is enhanced in diabetic retinopathy Katrien Van Raemdonck, M.I. Nawaz, M. Gouwy, G. Mohammad, D. Kangave, J. Van Damme, A.M. Abu El-Asrar, S. Struyf; Leuven, Belgium 655 P6.03.24 - Protein S attenuates streptozotocin-induced diabetes mellitus Taro Yasuma, C. Gabazza, T. Matsumoto, A. Yasukawa, Y. Matsushima, L. C.G.Ayshwarya, Z. Roeen, M. Toda, Y. Yano, E. Gabazza; Tsu-city, Japan 656 P6.03.25 - Effects of OPN and its cleavage products on human monocyte differentiation and survival Maximilian Zeyda, K. Schuch, T.M. Stulnig; Vienna, Austria 117 Posters - August 24 Panel N° 1.10 INNATE SENSORS Session Time: Saturday, August 24, 13:20 - 15:00 001 P1.10.01 - TLR4 and DC-SIGN receptors recognized Mycobacterium scrofulaceum promoting semi-activated phenotype on Bone Marrow Dendritic Cells M. Cruz, Antonia I. Castillo-Rodal, A. Schcolnik, L. Bonifaz, Y. López-Vidal; México, Mexico 002 P1.10.02 - NOD2 signaling promotes the Treg/Th17 imbalance and contributes to type 1 diabetes pathogenesis Frederico R.C. Costa, M.C.S. Françozo, J.S. Silva, D.C. Sartori; Ribeirão Preto, Brazil 003 P1.10.03 - Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy I. Stroo, A. Tammaro, F. Blank, L. Butter, N. Claessen, T. Takai, M. Colonna, J. Leemans, S. Florquin, Mark Dessing; Amsterdam, Netherlands 004 P1.10.04 - A shortcut mechanism of innate immune defense by a solitary PRR Jeak L. Ding, B. Ho; Singapore, Singapore 005 P1.10.05 - Orchestration of tissue repair by the humoral pattern recognition molecule PTX3: linking microbe and matrix recognition Andrea Doni, M. Sironi, T. Musso, C. Castagnoli, M. Gobbi, S. Valentino, S. Tartari, B. Bottazzi, C. Garlanda, A. Mantovani; Rozzano, Italy 006 P1.10.06 - Dectin-1 exerts opposing roles in the activation of macrophages from resistant and susceptible mice to Paracoccidioides brasiliensis infection Claudia Feriotti, V.L.G. Calich; São Paulo, Brazil 007 P1.10.07 - Induction of antimicrobial peptides in primary cultures from diabetic foot ulcers with 1,25-dihydroxyvitamin D3 and L-isoleucine Irma E. Gonzalez, V. Trujillo, A. Montoya, A. Enciso, K. Rincon, E. Avila, B. Rivas, B. Rivas-Santiago; Zacatecas, Mexico 008 P1.10.08 - Deficient antiviral responses to influenza in primary bronchial epithelial cells of chronic obstructive pulmonary disease Alan Hsu, K. Parsons, I. Barr, P. Hansbro, P. Wark; Newcastle, Australia 009 P1.10.09 - Zinc-Finger Antiviral Protein Mediates RIG-I-Like Receptor-Independent Antiviral Response to Murine Leukemia Virus Hanna Lee, J. Komano, T. Saitoh, S. Akira; Osaka, Japan 010 P1.10.10 - Potential role of caveolin-1 in regulation of immune cell activation Michaela Maceckova, M. Pekarova; Brno, Czech Republic 011 P1.10.11 - Unbiased screen to identify novel host factors involved in the innate immune recognition of Streptococcus pneumoniae Barbara Maier, H. Stöckl, S. Knapp; Vienna, Austria 012 P1.10.12 - C-type lectin receptor Mincle recognizes amphiphilic acylglucoside derived from Helicobacter pylori Masahiro Nagata, M. Shimamura, E. Ishikawa, T. Nabeshima, S. Yamasaki; Fukuoka, Japan 013 P1.10.13 - Natural IgG is not non-reactive: it plays a vital role in innate immune response Saswati Panda, J.L. Ding; Singapore, Singapore 014 P1.10.14 - Antibodies against dengue NS1 and prM proteins increase the sensitivity of dengue diagnosis and differentiate Japanese encephalitis infection Gowri Sankar S, S. John Vennison, R. Paramasivan, K. Dhananjeyan, V. Thenmozhi, B. Tyagi; Tiruchirappalli, India 015 P1.10.15 - Cloning and characterization of cytosolic DNA in tumors Yujia Shen, S. Gasser; Singapore, Singapore 016 P1.10.16 - Expression and role of the long pentraxin PTX3 in lymphatic endothelial cells Marina Sironi, A. Doni, F. Pasqualini, S. Valentino, I. Laface, M. Nebuloni, C. Garlanda, B. Bottazzi, A. Vecchi, A. Mantovani; Rozzano, Italy 017 P1.10.17 - Inhibition of interferon expression with small interference RNA increases adenoviruses-GFP transduction and transgene expression in Huh7 cells Ana A. Sobrevilla Navarro, A.S. Sandoval Rodríguez, J.J. García Bañuelos, P. Sanchez Hernández, L.D. Hernández Ortega, J. Gaona Bernal, J. Armendáriz Borunda, A.M. Salazar Montes; Guadalajara Jalisco, Mexico 018 P1.10.18 - ApoH an innate immune sensor and hunter that captures and scavenges infectious pathogens S. Tigrett, G. Dubois, E. Lucarz, I. Stefas, Francisco Veas; Montpellier, France 118 Posters - August 24 019 P1.10.19 - DAI (DLM-1/ZBP1) promotes lupus nephritis by activating calcium pathway Sidong Xiong, W. Zhang, W. Xu; Suzhou, Jiangsu Province, China 020 P1.10.20 - Functional Analyses of Recombinant Mouse hepcidin-1 in Cell Culture and Animal Model Yazdani Yaghoub, N. Keyhanvar; Gorgan, Iran, Islamic Republic of P1.15 INFLAMMASOME Session Time: Saturday, August 24, 13:20 - 15:00 021 P1.15.02 - Molecular differences of NLRP3 inflammasome activation in LPS-activated human monocyte-derived macrophage subtypes M.M. Budai, J. Danis, Á. Becsei, A. Varga, L. Csernoch, J. T zsér, Szilvia Benkő; Debrecen, Hungary 022 P1.15.04 - The impact of Butyrate on the NOD-like receptor pyrin domain-containing protein 6 (NLRP6)-inflammasome in humans Katja Brunner, M. Enea, S. Holly, K. Nigel, B. Mona; London, United Kingdom 023 P1.15.05 - Activation of the NLRP3 inflammasome promotes the pathogenic Th1/Th17 responses in type 1 diabetes murine model Daniela Carlos, J.N.U. Yaochite, F.R.C. Costa, S.G. Ramos, F.Q. Cunha, D.S. Zamboni, N.O. Camara, J.S. Silva; Ribeirão Preto, Brazil 024 P1.15.06 - Caspase-1 and MyD88 are involved in adaptive immune response induced by cytosolic flagellin Thaís B. da Costa, C.L. Freitas, V.M. Gonçalves, K.R. Bortoluci; São Paulo, Brazil 025 P1.15.07 - A novel, Cyclosporine A (CyA)-sensitive P2RX7 SNP haplotype linked to survival of immature antigen presenting cells (APC) in autoinflammation Sarah Dagenbach, A. Altmann, M. Lorenz, H. Hohmann, K. Foehr, E.M. Schneider; University Hospital Ulm, Germany 026 P1.15.08 - Deregulation of NLRP3 inflammasome is involved in progression of hepatocellular carcinoma Lihui Han, Q. Wei, K. Mu, T. Li, Y. Zhang, W. Huai, X. Jia; Jinan, China 027 P1.15.09 - Mistletoe lectin-mediated mmunostimulatory effect implicates the activation of NLRP3 inflammasome Pushpa Hedge, A. Friboulet, J. Bayry, S.V. Kaveri; Paris, France 028 P1.15.10 - Fine mapping of the mouse Irm1 locus controlling interleukin-1beta production J.R. Jensen, A. Galvan, W.H.K. Cabrera, O.G. Ribeiro, M. De Franco, N. Starobinas, R. Piazza, M. Dugo, T.A. Dragani, Olga M. Ibañez; São Paulo, Brazil 029 P1.15.11 - ASC inflammassome mediates IL-1β production and host resistance to Paracoccidioides brasiliensis Natalia Ketelut-Carneiro, F.A. Rocha, G.K. Silva, D.S. Zamboni, J.S. Silva; Ribeirao Preto, Brazil 030 P1.15.12 - ATP-mediated inflammasome activation is efficiently inhibited by acetylcholine Mira Kuellmar, A. Hecker, S. Wilker, S. Atanasova, A. Zakrzewicz, M. Meixner, A. Kaufmann, W. Kummer, W. Padberg, V. Grau; Giessen, Germany 031 P1.15.13 - Activation of NLRP3 inflammasome is associated with the progression of Alzheimer’s disease Francesca La Rosa, M. Saresella, E. Calabrese, I. Marventano, F. Piancone, D. Trabattoni, M. Biasin, M. Clerici; Milan, Italy 032 P1.15.14 - Cytosolic flagellin induces caspase-1/11-independent lysosomal cathepsins-mediated cell death that correlates to the control of S. typhimurium Silvia L. Lage, C.B. Lima, E.P. Amaral, K.C. Matteucci, M.M. Rodrigues, M.R. D’Império-Lima, G.P. Amarante-Mendes, K.R. Bortoluci; São Paulo, Brazil 033 P1.15.15 - Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein Ming-Zong Lai, Y. Lo, Y. Huang, Y. Wu, C. Tsai, S. Jiang, H. Shih; Taipei, Taiwan 034 P1.15.16 - Caspase-1-dependent iNOS activation require NF-κB and acts as a non-redundant effector mechanism agaisnt S. typhimurium Carina B. Lima, S.L. Lage, G.P.A. Mendes, K.R. Bortoluci; São Paulo, Brazil 035 P1.15.17 - NLRP3 inflammasome controls the cellular response to DNA damage during oxidative and genotoxic stress G. Licandro, H.L. Khor, O. Beretta, J. Lai, H. Derks, P. Ricciardi-Castagnoli, Alessandra Mortellaro; Singapore, Singapore 036 P1.15.18 - Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation Ida Paciello, A. Silipo, L. Lembo-Fazio, G. Noel, V. Ciancarella, A. Zychlinsky, A. Molinaro, M. Bernardini; Rome, Italy 037 P1.15.19 - Molecular mechanisms of caspase-11-mediated NLRP3 inflammasome activation Vijay Rathinam, S. Kailasan Vanaja, L. Waggoner, A. Sokolovska, C. Becker, L. Stuart, J. Leong, K. Fitzgerald; Worcester, United States 119 Posters - August 24 038 P1.15.20 - NLRP3-driven IL-1 production by Cryptococcus neoformans infection Pedro H.V. Saavedra, K.G. Magalhães, M. Capparelli, D.S. Zamboni, A.H. Tavares, A. Casadevall, A.L. Bocca; Brasilia, Brazil 039 P1.15.21 - Inflammation triggered by oncogene KRas in pancreatic tumor cells Imran Siddiqui, F. Marchesi, S. Pesce, M. Erreni, A. Mantovani, H.M. Kocher, P. Allavena; Milan, Italy 040 P1.15.22 - Uric acid-induced NLRP3 inflammasome contribute to diabetic kidney injury Kim Su-Mi, K. Jeong, S. Lee, T. Lee, C. Ihm, S. Lim, J. Moon; Seoul, Korea, Republic of 041 P1.15.23 - Transcriptional regulation of the anti-inflammatory NLRP12/Monarch-1 by NF-kB Sinem Tuncer, C. Camperio, G. Camilli, N. Porciello, E. Piccolella, M. Fiorillo, R. Sorrentino; Rome, Italy 042 P1.15.24 - The role of autophagy in macrophage-derived foam cells after Salmonella enterica serovar Typhimurium infection Tzu-Yuan Wang; Taoyuan, Taiwan P2.02 NUCLEAR RECEPTORS Session Time: Saturday, August 24, 13:20 - 15:00 043 P2.02.01 - A comparison of the biological features of prostate cancer with (PSA+,PSMA+) profile according to RKIP A. B. Jemaa, Y. Bouraoui, S. Sallami, Y. Nouira, R. Oueslati, Mouna Ben Azaiz; Bizerte, Tunisia 044 P2.02.02 - Matrix metalloproteinase 3 activates NFκB in cell nucleus during Dengue virus infection Jianfeng Dai; Suzhou, China 045 P2.02.03 - Tumor inflammatory environment modulates expression of PPAR-γ, inflammasome activation and triggers prostate cancer cell death in vitro Rafaela S. Fontenele, N.M. Vasconcelos, B.C. Guido, K.G. Magalhães, J.R. Corrêa; Brasilia, Brazil 046 P2.02.04 - Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice Manabu Kinoshita, H. Miyazaki, H. Nakashima, M. Ikarashi, S. Seki; Tokorozawa, Japan P2.03 EPIGENETIC CONTROL OF IMMUNE RESPONSES Session Time: Saturday, August 24, 13:20 - 15:00 047 P2.03.01 - Polycomb repressive complex-1 is critical for peripheral B cell differentiation and germinal center responses Federica Alberghini, L. D’Artista, F. Mainoldi, F. Pisati, C. Carrisi, H. Koseki, M. Vidal, S. Casola; Milano, Italy 048 P2.03.02 - The rheumatoid factor in idiotypic regulation of autoimmunity Liubov Beduleva, I. Menshikov, E. Stolyarova, O. Lobanova; Izhevsk, Russian Federation 049 P2.03.03 - Interleukin-10 suppresses CXCL8 gene transcription in LPS-stimulated monocytes via modulation of histone deacetylases (HDACs) recruitment Monica Castellucci, M. Rossato, N. Tamassia, S. Gasperini, F. Bazzoni; Verona, Italy 050 P2.03.05 - Methylation patterns near and inside of the TSLP promoter in an african descendent population of Colombia Luis Fang, A.J. Manrique, J.J. Builes, L. Hernandez, D.P. Aguirre, C. Muñoz, B. Martínez, J. Marrugo; Cartagena, Colombia 051 P2.03.06 - Tumor Necrosis Factor Gene Polymorphisms in Tunisian Patients with Non -Small Cell Lung Cancer Safa Kaabachi W.A.K. Fayçal Haj Sassi; Tunis, Tunisia 052 P2.03.07 - Locus-specific biochemical epigenetics / chromatin biochemistry by insertional chromatin immnoprecipitation (iChIP) Toshitsugu Fujita, H. Fujii; Suita, Osaka, Japan 053 P2.03.08 - The Research on IFN-γ,IL-4 Gene Methylation of Uighurs and Han Patients with Allergic Rhinitis in Xinjiang of China Li Gao, X.f. Jiang, Q. Yang, Q.Q. Zhang, N.R. Mu, F.T. Liu, Z.Z. Lou; Urumqi, China 054 P2.03.09 - Pronounced co-localization of immunoglobulin genes and their enhancers in transcription factories at the nuclear periphery in plasma cells S. Park, Y. Xiang, William T. Garrard; Dallas, United States 055 P2.03.10 - Testing the resource-reallocation hypothesis: influence of maternal testosterone on immune system of Japanese quail (Coturnix japonica) chicks Zuzana Kanková, M. Okuliarová, M. Zeman; Bratislava 4, Slovakia 120 Posters - August 24 056 P2.03.11 - Heterogeneity of Polycomb repressive complexes and long-noncoding RNA dictate the regulation network of thymic T cell development Masamoto Kanno, Y. Guo, K. Weng-Sheng, A. Nobukiyo, H. Inoue; Hiroshima, Japan 057 P2.03.12 - Epigenetic regulation of T cell Ig mucin 3 expression in Th1 cells reveals a novel control of adaptive immunity Chih-Chi Kuo, F. Chou, Y. Lin, H. Sytwu; Taipei, Taiwan 058 P2.03.13 - DNA methylation changes in allergic patients correlate with symptom severity and reflect altered CD4+ T-cell population structure Antonio Lentini, C.E. Nestor, M. Gustafsson, H. Wang, H. Zhang, S. Bruhn, F. Barrenäs, M. Benson; Linköping, Sweden 059 P2.03.14 - Targeted disruption of Calcium/NFAT signaling reveals a left-right determination disorder in the pharyngeal arch artery Yukihisa Miyachi; Suita, Japan 060 P2.03.15 - Activation of Aryl hydrocarbon receptor (AhR) triggers epigenetic and microRNA modulation and consequent differential regulation of Tregs and Th17 cells and amelioration of Experimental Autoimmune Encephalomyelitis (EAE) Mitzi Nagarkatti, N.P. Singh, P. Nagarkatti; Columbia, United States 061 P2.03.16 - Epigenetic regulation of cytokine production in sepsis and endotoxin tolerance Claudia Reschke, D. Ibrahim, J. Hecht, H. Volk, G. Grütz; Berlin, Germany 062 P2.03.17 - Impact of Wnt pathway activation in liver infiltrating T lymphocytes Valeria Schinzari, C. Martire, M. Rossi, S. Brozzetti, V. Barnaba; Rome, Italy 063 P2.03.18 - Evidence for in vivo DNA demethylation at Interferon-γ promoter site CpG island during human endotoxemia Brendon P. Scicluna, M. Wevel, H. Belkasim, A. van der Meer, R. Lutter, T. van der Poll; Amsterdam, Netherlands 064 P2.03.19 - Differential effects of histone-deacetylase inhibition during lipopolysaccharide-induced lung inflammation in mice Anne J. van der Meer, S.S. Zeerleder, C. van ‘t Veer, T. van der Poll; Amsterdam, Netherlands P2.04 MICRORNAS IN IMMUNE REGULATION Session Time: Saturday, August 24, 13:20 - 15:00 065 P2.04.01 - miR-146, miR-21, and miR-31 expression in patients with active tuberculosis and subjects with latent tuberculosis infection E. Alijani, A. Poorfatholah, B. Sharifi Mood, A. Ahmad Zavaran Hosseini, Soheila Ajdary; Tehran, Iran, Islamic Republic of 066 P2.04.02 - MicroRNA-mediated regulation of the pattern recognition receptor PTX3 Elisa Barbati, L. Mori, L. Zammataro, M. Rubino, A. Mantovani, C. Garlanda, M. Locati; Rozzano, Milano, Italy 067 P2.04.03 - MiR-217 is an oncogene that enhances the germinal center reaction Nahikari Bartolomé-Izquierdo, V. G de Yébenes, R. Nogales-Cadenas, P. Pérez-Durán, D. F Robbiani, M. Cañamero, A. Pascual-Montano, A. R Ramiro; Madrid, Spain 068 P2.04.04 - The effect of tumor cell derived exosomes on mesenchymal stem cells A. Marton, M. Harmati, R. Katona, E. Gyukity-Sebestyén, I. Nagy, B. Horváth, C. Vizler, E. Duda, A. Borsodi, Krisztina Buzas; Szeged, Hungary 069 P2.04.05 - MicroRNA modulations in plasmacytoid dendritic cell hyperactivity in systemic lupus erythematosus Vera S. Chan, S. Yan, R.C.Y. Tam, N. Shen, C.S. Lau; Pokfulam, Hong Kong 070 P2.04.06 - MicroRNA profiling in giant cell arteritis: diagnostic and prognostic potential Stefania Croci, A. Zerbini, G. Pazzola, D. Nicoli, E. Farnetti, B. Casali, A. Cavazza, L. Boiardi, M. Parmeggiani, C. Salvarani; Reggio Emilia, Italy 071 P2.04.07 - MicroRNAs dysregulation in human Chagas cardiomyopathy Ludmila R.P. Ferreira, R.H. Santos, M.A. Baron, I. Navarro, P.C. Teixeira, N.A. Stolf, E. Bocchi, A. Fiorelli, J. Kalil, E. Cunha-Neto; São Paulo, Brazil 072 P2.04.08 - Does HCMV employ miRNA mediated regulation to counter the antiviral mechanisms to maintain long latency periods in Humans? An in silico study Sunil B. Gosipatala, S. Saxena; Lucknow, India 073 P2.04.09 - Anti-microRNA-378 Enhances Wound Healing Process by Up-regulating Vimentin and Integrin beta-3 Haoran Li, B. Yang; Toronto, Canada 121 Posters - August 24 074 P2.04.10 - Global effect of IL-10-induced modulation of miRNAs expression on cytokine production by LPS-stimulated human monocytes Barbara Mariotti, M. Rossato, M. Castellucci, S. Gasperini, F. Bazzoni; Verona, Italy 075 P2.04.11 - TNF influences microRNA expression during T cell activation Viktor Molnár, B. Molnár-Érsek, E. Buzás, A. Falus, G. Nagy; Budapest, Hungary 076 P2.04.12 - The miR-17-92 cluster is regulating naive T cell homeostasis as well as effector and memory differentiation Gwennaelle C. Monnot, J.C. Dudda, B. Salaun, D. Utzschneider, D. Zehn, P. Romero; Epalinges, Switzerland 077 P2.04.13 - Double stimuli by TLR7 and CD11c+ may change microRNA expression in murine plasmacytoids dendritic cells Everton Padilha, T. Malardo, I.C. Fontoura, J.C.C. Lorenzi, B.P. Moreira, C.L. Silva, A.A.M. Coelho-Castelo; Ribeirao Preto, Brazil 078 P2.04.14 - Anti-inflammatory function of miR-146a in human primary keratinocytes and atopic dermatitis Ana Rebane, T. Runnel, A. Aab, B. Rückert, J. Maslovskaja, M. Zimmermann, M. Plaas, L. Kemeny, K. Kingo, C.A. Akdis; Davos, Switzerland 079 P2.04.15 - Negative regulation of Toll-like receptor 4 signaling by the IL-10-dependent miR-146b Tiziana A. Renzi, G. Curtale, M. Mirolo, M. Locati; Rozzano, Italy 080 P2.04.16 - The role of microRNA 155 in innate immunity and arthritis Victoria Saferding, E. Goncalves-Alves, A. Puchner, J. Smolen, K. Redlich, S. Blüml; Vienna, Austria 081 P2.04.17 - Association of microRNA-146a target gene IRAK-1 polymorphism with enthesitis related arthritis category of juvenile idiopathic arthritis Sushma Singh, A. Aggarwal; Lucknow, India 082 P2.04.18 - Regulated expression of microRNA-21 is involved in memory T-cell survival Katarzyna Smigielska-Czepiel, A. van den Berg, P.G. Jellema, H. Maat, R.J. van der Lei, E. Brouwer, A.M.H. Boots, B.J. Kroesen; Groningen, Netherlands 083 P2.04.19 - Aged T cell subsets are characterized by a distinct microRNA signature Nato Teteloshvili, A. van den Berg, N. van der Geest, R.J. van der Lei, P. Jellema, E. Brouwer, A.M.H. Boots, B.J. Kroesen; Groningen, Netherlands 084 P2.04.20 - MicroRNA-mediated regulation of TLR4 by immunosuppressive agent increases susceptibility to bacterial infections Emilie Tourneur, C. Chassin; Paris cedex 18, France 085 P2.04.21 - Genome-wide identification of differentially expressed microRNAs in human plasma cell differentiation revealed crucial microRNAs involved Dong-Yan Tsai, S. Wu, C. Chung, A.C. Shih, K. Lin; Taipei, Taiwan 086 P2.04.22 - Evaluation of expression pattern of miRNA146a in Pakistani rheumatoid Arthritis Patients Sami Ullah, P. John, A. Bhatti; Islamabad, Pakistan 087 P2.04.23 - Functional analysis for microRNA involving in arthritis Tomo Yonezawa; Chiba, Japan 088 P2.04.24 - Mir-34a promotes the development of Plasmacytoid dendritic cell Jinping Zhang; Suzhou, China P3.07 B CELL DEVELOPMENT AND PLASMA CELL DIFFERENTIATION Session Time: Saturday, August 24, 13:20 - 15:00 089 P3.07.01 - Differential expression of CD21 in different species Marek Šinkora, J. Šinkorová; Nový Hrádek, Czech Republic 090 P3.07.02 - Immunologic Alterations in Long-Term Divers Hassan Abolhassani, A. Aghamohammadi, N. Rezaei, K. Ghorban, B. Dormanesh; Tehran, Iran, Islamic Republic of 091 P3.07.03 - Class Switch Recombination Process in Common Variable Immunodeficiency Asghar Aghamohammadi, H. Abolhassani, S. Moazzeni, A. Salek Farrokhi, P. Mohammadinejad, B. Mirminachi; Tehran, Iran, Islamic Republic of 092 P3.07.04 - Class Switch Recombination Process in Common Variable Immunodeficiency Asghar Aghamohammadi, H. Abolhassani, P. Mohammadinejad, A. Salek Farrokhi, S. Moazzeni, B. Mirminachi; Tehran, Iran, Islamic Republic of 122 Posters - August 24 093 P3.07.05 - Allelically included B cells with two specificities are eliminated in the periphery Leen Baudewijn, S. Gjoerup Saekmose, C. Dellgren, T. Barington; Odense, Denmark 094 P3.07.06 - High-throughput mutant mouse characterisation is a powerful tool to identify novel immune phenotypes Emma L. Cambridge, A.O. Speak, S. Clare, T. Sanger Mouse Genetics Project, R. Ramirez-Solis, D.J. Adams, G. Dougan, J.K. White; Cambridge, United Kingdom 095 P3.07.07 - Functional analysis of synaptobrevin family members in secretion of antibodies by human plasma cells L. Gómez-Jaramillo, L. Delgado-Pérez, F. Mora-López, R. Romero-García, G. Jiménez-Gómez, A. García-Poley, J.A. Brieva, Antonio Campos-Caro; Cádiz, Spain 096 P3.07.08 - B cell responses toward bacterial pathogens in human tonsils Elisa Faenzi, F. Buricchi, E. Viciani, G. Santoro, F. Bagnoli, M. Barocchi, F. Castellino, G. Del Giudice, A. Manetti, O. Finco; Siena, Italy 097 P3.07.09 - Ectonuclotidase activity in class switch recombination of murine B cells Caterina E. Faliti, R. Rigoni, M. Proietti, E. Traggiai, F. Grassi; Bellinzona, Switzerland 098 P3.07.10 - Primary Antibody Deficient Patients and ENT Complication Alireza Ghajar, A. Aghamohammadi, A. Kouhi, M. Tavakol, M. Afarideh, H. Abolhassani; Tehran, Iran, Islamic Republic of 099 P3.07.11 - IL-4 promotes B cell maturation in synergy with BAFF and confers resistance to cell death in negative selection checkpoints Alessandra Granato, B. Baptista, M. Bellio, A. Nóbrega, E. Hayashi; Rio de Janeiro, Brazil 100 P3.07.12 - The hierarchical process of differentiation of long-lived antibody-secreting cells is dependent on integrated signals derived from antigen and IL-17A Lidiane Z. Grund, M. Lopes-Ferreira, C. Lima; São Paulo, Brazil 101 P3.07.13 - Granzyme B-secreting B cells: suicidal or lethal? Magdalena Hagn, D. Brasacchio, A. Brennan, J. Lopez, K. Thia, V. Sutton, J.A. Trapani; Melbourne, Australia 102 P3.07.14 - Participation of arginine methyltransferase 1 in B cell development and differentiation Kikumi Hata, N. Yanase, E. Takada, J. Mizuguchi; Tokyo, Japan 103 P3.07.15 - Distinct processing of the pre-B cell receptor and the B cell receptor J. Haimovich, S. Cohen, M. Toren, Nurit Hollander; Tel Aviv, Israel 104 P3.07.16 - A functional BCR in human IgA and IgM plasma cells D. Pinto, E. Montani, F. Sallusto, A. Lanzavecchia, David Jarrossay; Bellinzona, Switzerland 105 P3.07.17 - The surrogate light chain selects Mu heavy chain based on its DH CDR-H3 sequence Mohamed A. Khass, L. Watkins, Y. Zhuang, E. Capriotti, P.D. Burrows, H.W. Schroeder Jr.; Birmingham, United States 106 P3.07.18 - Therapeutic effects of anti-APRIL blocking antibody on murine IgA nephropathy Yang Gyun Kim, Y. Suzuki, H. Bertrand, H. Suzuki, M. Maikuma, M. Muto, S. Izui, S. Hirose, Y. Tomino; Seoul, Korea, Republic of 107 P3.07.19 - SLAM-dependent and independent mechanism of IgE induction Akihiko Kitoh, N. Kusuba, Y. Miyachi, S. Sakaguchi, Y. Yanagi, K. Kabashima; Kyoto, Japan 108 P3.07.20 - Differences between IgG4+ and IgG1+ B cells provide insight into regulation of the IgG4 response Laura C. Lighaam, E. Vermeulen, E.L. Culver, K.J. Meijlink, T.H. den Bleker, P. Ooijevaar-de Heer, E. Barnes, R.C. Aalberse, S.M. van Ham, T. Rispens; Amsterdam, Netherlands 109 P3.07.21 - The role of the histone demethylase Jmjd3 in B-cell lymphopoiesis Rahmat Mahshid, T. Burgold, B. Khoramian, M. Caganova, F. Mainoldi, M. Reth, G. Natoli, G. Testa, S. Casola; Milano, Italy 110 P3.07.22 - Protease-activated receptor (PAR)1 and PAR2 have opposing effects on B-lymphocyte function during different stages of maturation Kelly J. McKelvey, Y. Chan, C.J. Jackson, M. Xue; St Leonards, Australia 111 P3.07.23 - Ataxia Telangiectasia Patients Presented by Class Switch Recombination Defect: Elevated Serum Levels of IgM Babak Mirminachi, A. Aghamohammadi, H. Abolhassani, S. Ghosh, A. Borkhardt; Tehran, Iran, Islamic Republic of 112 P3.07.24 - B cell development undergoes profound changes during pregnancy Damián O. Muzzio, A.C. Zenclussen, F. Jensen; Magdeburg, Germany 123 Posters - August 24 113 P3.07.25 - Influence of Wnt5a treatment on B-1 cells viability in vitro Lika Osugui, M.C.T. Novo, M.F.L. Laurindo, A.F. Popi; Sao Paulo, Brazil 114 P3.07.26 - Effects of Ouabain on B and T lymphocytes at mice R.P.S. Barbosa, T.A.G. Vianna, J.M.C. Silva, K.M. Costa, F.B. Do Canto, V.R. Cabral, R. Fucs, Luciana S. Paiva; Niterói/RJ, Brazil 115 P3.07.27 - Combination effect of LPS and MDP on antibody production by mouse B cells S. Lee, Y. Yoo, J. Lee, P. Kim, G. Seo, Seok-Rae Park; Daejeon, Korea, Republic of 116 P3.07.28 - Immunization of Common Variable Immunodeficiency (CVID) patients with Influenza induces increase in switched memory B cells and plasmablasts Maíra Pedreschi, A.K.B. Oliveira, M.T. Barros, A. Cohon, J. Kalil, C.M. Kokron; Sao Paulo, Brazil 117 P3.07.29 - CD38 ligation promotes proliferation and ERK phosphorylation of bone marrow B-cell precursors in mice Hector Romero-Ramirez, M. Morales-Guadarrama, R. Pelayo-Camacho, R. Lopez-Santiago, L. Santos-Argumedo; Mexico, Mexico 118 P3.07.30 - Patients with X-linked Agammaglobulinemia Survival Rate : Mortality and Morbidity A. Aghamohammadi, H. Abolhassani, F. Sefatgol, F. Shahriari, S. Sefatgol, Masoud Sefatgol; Tehran, Iran, Islamic Republic of 119 P3.07.31 - Retinoic acid acts as a selective human IgA switch factor Goo-Young Seo, S. Park, J. Kim, Y. Jang, J. Lee, H. Han, S. Kang, S. Kim, B. Jin, S. An, J. Choe, P. Kim; Chuncheon, Korea, Republic of 120 P3.07.32 - Adaptor protein Swiprosin2/EFhd1 during early B cell development Merle Stein, S. Dütting, S. Brachs, W. Schuh, A. Turqueti-Neves, D. Vöhringer, H. Jäck, D. Mielenz; Erlangen, Germany 121 P3.07.33 - Serine/threonine phosphatase PP4 is required for pro-B cell development by promoting Ig VDJ recombination Yu-wen Su, T. Tan; Zhunan, Miaoli County, Taiwan 122 P3.07.34 - Y-Chromosome-linked B- and NK-cell deficiency in mice Shu-lan Sun, A. Asao, T. Takahashi, T. So, M. Kondo, N. Ishii; Sendai, Japan 123 P3.07.35 - ACKR3 (CXCR7) expression on late germinal center B cells Marcus Thelen; Bellinzona, Switzerland 124 P3.07.36 - Inhibition of germinal center formation and humoral immune responses by EB virus protein LMP1 Chiau-Yuang Tsai, T. Yasui, T. Minamitani, K. Morita, S. Sakakibara, H. Kikutani; Osaka, Japan 125 P3.07.38 - B cell-intrinsic role of DOCK2 in T cell-dependent humoral immunity Miho Ushijima, A. Nishikimi, Y. Fukui; Fukuoka, Japan 126 P3.07.39 - Impact of genetic deficiencies in the TLR signaling pathways on human IgM+IgD+CD27+ B cells Sandra Weller, S. Storck, L. Israel, S. Zhang, A. Puel, J.L. Casanova, C. Picard, J.C. Weill, C.A. Reynaud; Paris, France 127 P3.07.40 - Follicular dendritic cells induce a new class of myeloid cells with unique B cell stimulating activities: specific dependence on IL-34/CSF-1R signaling pathway Fumihiro Yamane, K. Matsui, H. Tanimoto, E. Iwasaki, M. Asakura, H. Tokumitsu, Y. Nishikawa, N. Kanayama, M. Magari, H. Ohmori; Okayama, Japan 128 P3.07.41 - The Non-Canonical function of UNG in AID induced Antibody Gene Diversification Ashraf S. Yousif, N.A. Begum, T. Honjo; Kyoto, Japan P3.11 GAMMA-DELTA T CELLS Session Time: Saturday, August 24, 13:20 - 15:00 129 P3.11.01 - CD2 expression determines two lineages of γδ T cells in swine Marek Sinkora, K. Stepánová; Nový Hrádek, Czech Republic 130 P3.11.02 - IL-17-producing gamma-delta T cells are crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice Aoi Akitsu, H. Ishigame, S. Kakuta, S. Saijo, Y. Iwakura; Chiba, Japan 131 P3.11.03 - Changes in Granzyme B expression in gamma delta T-cell in (HTLV-1)-associated myelopathy/tropical spastic paraparesis patients Raquel C. Albuquerque, O. Espindola, M.A. Lima, A.C.C. Leite, M.J. Andrada-Serpa, J. Echevarria-Lima; Rio de Janeiro, Brazil 124 Posters - August 24 132 P3.11.04 - Involvement of γδ-T cells in the pathogenesis of autoimmune skin disorder: Pemphigus vulgaris Vivek Anand, A. Raju, D. Das, S. Khandpur, V. Sharma, A. Sharma; New Delhi, India 133 P3.11.05 - Exploiting NKG2D and lymphoid stress surveillance response in seronegative spondyloarthritis Elisa Binda, A. Manzo, B. Vitolo, S. Bugatti, C. Montecucco; Pavia, Italy 134 P3.11.06 - T Cell Dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Ekua W. Brenu, S.L. Hardcastle, T.K. Huth, L. Cosgrave, D.R. Staines, S.M. Marshall-Gradisnik; Gold Coast, Australia 135 P3.11.07 - In vivo IFN-alpha/ribavirin treatment modulates Vγ9Vδ2 T-cell function during chronic HCV infection Eleonora Cimini, C. Bonnafous, H. Sicard, C. Vlassi, G. D’Offizi, M. Capobianchi, F. Martini, C. Agrati; Rome, Italy 136 P3.11.08 - γδ T cells are required for the development of autoimmune anti myeloperoxidase glomerulonephritis Poh-Yi Gan, J.D. Ooi, S.A. Summers, D. Odobasic, A.R. Kitching, S.R. Holdsworth; Melbourne, Australia 137 P3.11.09 - Differentiation of human peripheral blood Vδ1 T cells expressing Natural Cytotoxicity Receptors: implications for immunotherapies and the understanding of γδ T cell function Kelly Hudspeth, D.V. Correia, M. Fogli, M. Gomes da Silva, J. Mikulak, A. Roberto, S. Della Bella, B. Silva-Santos, D. Mavilio; Rozzano, Italy 138 P3.11.10 - Mycobacterium tuberculosis antigen specific changes of CDR3 length distribution of Vδ2 chain of human γδ T lymphocytes Baiqing Li, F. Ma, Y. Ding, Z. Wang, S. Guo, D. Xu, Y. Chen, J. Tang; Bengbu, China 139 P3.11.11 - Respiratory syncytial virus infection influences FasL-mediated apoptosis of γδ T cells in a murine model of allergen sensitization Beixing Liu, S. Zeng, J. Liu, F. Qi; Shenyang, China 140 P3.11.12 - Sensing cellular stress by γδ TCR Romain Marlin, H. Kaminski, S. Netzer, V. Pitard, C. Harly, E. Scotet, J. Moreau, J. Dechanet-Merville; Bordeaux, France 141 P3.11.14 - Understanding the crosstalk between γδ T cells and osteoclasts in patients with breast cancer Swati P. Phalke, V. Parmar, R. Badwe, S. Chiplunkar; Navi Mumbai, India 142 P3.11.15 - Toll-like receptor 2 ligand enhances effector function but not antigen presentation properties of gamma-delta T cells Desmond Poo, W. Wang, M. Teo, H. Toh; Singapore, Singapore 143 P3.11.16 - Phenotypic characterisation of Human Vγ9Vδ2 T-cells Paul L. Ryan, L.A. Bergmeier, D.J. Pennington; London, United Kingdom 144 P3.11.17 - Human peripheral Vδ1+ γδ T cells can develop into αβ T cells H. Ziegler, J. Haarer, M. Sterk, H. Rammensee, R. Handgretinger, Karin Schilbach; Tübingen, Germany 145 P3.11.18 - The regulatory role of TCR Vδ1+ ΝΚT cells in systemic sclerosis patients with interstitial pneumonia Segawa Seiji, D. Goto, M. Horikoshi, I. Matsumoto, T. Sumida; Ibaraki, Japan 146 P3.11.19 - γδ T cells react against the murine cytomegalovirus Sabrina Sell, M. Dietz, A. Schneider, M. Mach, T. Winkler; Erlangen, Germany 147 P3.11.20 - TCR requirements for γδ T cell development Nital Sumaria, D.J. Pang, J.F. Neves, K.V. Stoenchev, B. Silva-Santos, D.J. Pennington; Whitechapel, United Kingdom 148 P3.11.21 - CD30L/CD30 signaling plays a critical role in maintenance and activation of IL-17A-producing γδ T cells in mucosa-associated tissues in mice Xun Sun, E.R. Podack, Y. Yoshikai, C. Lu; Shenyang, China 149 P3.11.22 - Developing a protocol for large scale generation of antigen-pulsed gamma-delta T cells for cancer immunotherapy Who-Whong Wang, K. Poo, M. Teo, H. Toh; Singapore, Singapore 150 P3.11.23 - The role of phosphoantigen-expanded human γδ-T cells in the control of Epstein-Barr virus infection Zheng Xiang, J. Zheng, Y. Liu, G. Qin, Y. Liu, J. Guan, K. Lam, Y. Lau, W. Tu; Hong Kong, Hong Kong 151 P3.11.24 - Assessment of immune dysfunction in IgA-nephropathy patients Mariya Yurkevich, H. Ivanchik, S. Bagatka, K. Komissarov, V. Pilotovich, M. Zafranskay; Minsk, Belarus 125 Posters - August 24 P3.12 FOLLICULAR HELPER T CELLS Session Time: Saturday, August 24, 13:20 - 15:00 152 P3.12.01 - MyD88 activated Monocyte-derived CD11b+ dendritic cells enhance Follicular Helper T cell differentiation Svetoslav Chakarov, N. Fazilleau; Toulouse, France 153 P3.12.02 - Regulation and B-cell help mediated by distinct subsets of IL-10-producing T-cells Federica Facciotti, B. Haeringer, N. Gagliani, M. Paroni, P. Gruarin, L. Pignataro, R. Flavell, S. Abrignani, J. Geginat; Milan, Italy 154 P3.12.03 - Role of Notch signal in the generation of follicular helper T cells (TFH) and memory T cell Yohsuke Harada, K. Tokoyoda, K. Miyauchi, Y. Harada, A. Hanazawa, S. Ohno, Y. Yanagi, T. Takemori, M. Kubo; Noda, Japan 155 P3.12.04 - Role of BCL6 and PD-1 in CD4 memory T cell development Kristin Hollister, H. Wu, A. Dent; Indianapolis, United States 156 P3.12.05 - B cell antigen presentation induces Tfh-differentiation from Th2 cells in vitro Shu Horiuchi, H. Takebuchi, S. Konishi, K. Haniuda, T. Moutai, S. Takatsuka, D. Kitamura; Noda-City, Chiba, Japan 157 P3.12.06 - ICOS is critical for maintenance of the T follicular helper phenotype R.K. Franke, J.P. Weber, F. Fuhrmann, M. Al Baz, D. Vu Van, H.W. Mages, R.A. Kroczek, Andreas Hutloff; Berlin, Germany 158 P3.12.07 - A positive feedback loop between splenic long-lived plasma cells and follicular helper T cells Eunkyeong Jang, W. Chp, J. Youn; Seoul, Korea, Republic of 159 P3.12.08 - Roles of follicular helper T (TFH) cells in antibody based protective immunity in influenza virus vaccination Masato Kubo, K. Miyauchi, A. Sugimoto-Ishige, T. Kaji, Y. Takahashi, T. Takemori; Yokohama, Japan 160 P3.12.09 - Costimulation through GITR increases follicular helper T cell formation and leads to control of a chronic viral infection M.F. Pascutti, C. Brandao, R.W. van Olffen, T. Poplonski, R.A.W. van Lier, Martijn A. Nolte; Amsterdam, Netherlands 161 P3.12.10 - The implications of skin epidermal and dermal antigen-presenting cells in T follicular helper cell polarization Charles Nuttens, L. Chonco, O. Bonduelle, S. Munier, B. Verrier, B. Combadiere; Paris, France 162 P3.12.11 - Regulation of follicular helper T cells in Peyer’s patches by endoluminal ATP Andrea Romagnani; Bellinzona, Switzerland 163 P3.12.12 - TLR9 signaling acts on multiple elements of the germinal center to enhance antibody responses Derek Rookhuizen, A.L. DeFranco; San Francisco, United States 164 P3.12.13 - Antibody production and T forlicular helper response in mice immunized with modified HIV-1 envelope gp120 H. Yu, D. Tian, J. Wang, X. Wang, C. Guo, Y. Li, Min Zhuang, H. Ling; Harbin, China P3.14 B CELLS IN AUTOIMMUNITY AND REGULATORY B CELLS Session Time: Saturday, August 24, 13:20 - 15:00 165 P3.14.01 - Immunoglobulins, Zn and NO in newly diagnosed children with type 1 diabetes Mourad Aribi, I. Benghalem, K. Labadi, L. Hamouda, W. Meziane, M. Lammani; Tlemcen, Algeria 166 P3.14.03 - FcγRIIb modulates IL-10 secretion by regulatory B cells: Implications for systemic sclerosis A. Ferrier, O. Aravena, K. Pino-Lagos, J. Aguillón, L. Soto, Diego F. Catalan; Santiago, Chile 167 P3.14.04 - Effects of fingolimod therapy on B cell biology in multiple sclerosis Nele Claes, J. Fraussen, B. Van Wijmeersch, P. Stinissen, R. Hupperts, V. Somers; Diepenbeek, Belgium 168 P3.14.05 - Altered lymphoid organogenesis yet normal development of T-cell mediated autoimmunity in mice with skewed B-cell differentiation Emanuela Colombo, P. Tentorio, S. Musio, K. Rajewsky, R. Pedotti, S. Casola, C. Farina; Milan, Italy 169 P3.14.06 - Accumulation of circulating autoreactive naïve B cells reveal defects of early B cell tolerance checkpoints in patients with Sjögren’s syndrome Elisa Corsiero, N. Sutcliffe, H. Wardemann, C. Pitzalis, M. Bombardieri; London, United Kingdom 170 P3.14.07 - Characterization of regulatory B cells in rodent model, able to transfer allograft tolerance via the TGFbeta pathway Justine Durand, C. Usal, E. Merieau, M. Heslan, E. Chiffoleau; Nantes, France 126 Posters - August 24 171 P3.14.08 - Protection from autoimmune nephritis in mice transgenic for BAFF, but lacking CD19 Kirsten A. Fairfax, F. MacKay-Fisson; Melbourne, Australia 172 P3.14.09 - BAFF polymorphisms in Tunisian systemic lupus erythematosus patients Yousr Gorgi, I. Sfar, T. Dhaouadi, N. Laamiri, S. Turki, L. Ben Hassine, T. Ben Abdallah; Tunis, Tunisia 173 P3.14.10 - Direct PD-1-mediated suppression of autoreactive B cells by regulatory T cells Janine Gotot, C. Gottschalk, P.A. Knolle, H. Yagita, C. Kurts, I. Ludwig-Portugall; Bonn, Germany 174 P3.14.11 - Zap70+ b cells and plasmablasts as markers of disease activity and remission in systemic lupus erythematosus renal involvement Elisa Gremese, M. Nowik, L. Petricca, M. Gigante, L. Messutti, S. Canestri, C. Di Mario, G. Marino, B. Tolusso, G. Ferraccioli; Rome, Italy 175 P3.14.12 - The precursor BCR suppresses T cell-dependent autoimmune responses Ola Grimsholm, W. Ren, A.I. Bernardi, N. Höök, B. Bergmann, A. Stern, N. Cavallini, A. De Riva, I. Gjertsson, I. Mårtensson; Gothenburg, Sweden 176 P3.14.13 - Functional properties of resident B cells in arterial walls of human atherosclerotic patients Moustafa Hamze, C. Desmetz, C. Guzman, P. Roger, M. Berthe, N. Boulle, P. Branchereau, E. Picard, C. Tolza, P. Guglielmi; Montpellier, France 177 P3.14.14 - Epigenetic manipulation of protective and pathogenic antibody responses with histone deacetylase inhibitors Edwin D. Hawkins, M. Waibel, A. Frew, M. Hibbs, J. Shortt, R. Tothill, D. Tarlinton, R. Johnstone; London, United Kingdom 178 P3.14.15 - Systemic immunoglobulin G to human dentin fractions decreases during orthodontic treatment Eiko N. Itano, C.E.O. Lima, L.A. Nagashima, M.S. Kaminami, F.A. Nakanishi-Ito, E.T. Carlotto, E.O. Tanaka, T.T.M.P. Costa; Londrina, PR, Brazil 179 P3.14.16 - Inhibition of formation of IgA1-containing immune complexes in IgA1 nephropathy Alena Kasperova, H. Ueda, M. Stuchlova-Horynova, B. Julian, J. Novak, M. Raska; Olomouc, Czech Republic 180 P3.14.17 - Can B cells induce the generation of regulatory T cells? H.H. Mohammed Ali, Anna Kowalik, E. Kiernozek, E. Kozlowska, N. Drela; Warsaw, Poland 181 P3.14.18 - IL-7 modulates B cells survival and activation by inducing BAFF and CD70 expression in T cells Rebecka Lantto, S. Sammicheli, N. Ruffin, N. Vivar, F. Chiodi, B. Rethi; Stockholm, Sweden 182 P3.14.19 - Bendamustine increases interleukin-10 secretion from B cells Lu Le, A. Morita, K. Yoshimoto, H. Kameda, T. Takeuchi; Tokyo, Japan 183 P3.14.20 - B-1 lymphocytes modify global gene expression by murine melanoma cells P. Xander, R.R. Novaes e Brito, E.C. Pérez, J.M. Pozzibon, C.F. Souza, R. Pelegrino, V. Bernardo, M.G. Jasulionis, M. Mariano, José D. Lopes; São Paulo, Brazil 184 P3.14.21 - A novel flow-cytometry-based method to evaluate autoreactivity enables the study of B cell tolerance checkpoints in mice Emiliano Marasco, N. Manjarrez-Orduño, T. Hopkins, A. Athanassiou, J. Kiridly, P. Gregersen, B. Diamond; Manhasset, United States 185 P3.14.22 - Strain-specific positive and negative regulatory roles for TLR9 in a mouse model of SLE Robyn E. Mills, V. Lam, A. Weiss, M.L. Hermiston; San Francisco, United States 186 P3.14.23 - Mast cells contribute to the expansion and differentiation of IL-10-producing B cells Francesca Mion, F. D’Incà, L. Danelli, B. Frossi, C. Guarnotta, A. Burocchi, C. Tripodo, M.P. Colombo, G. Vitale, C.E. Pucillo; Udine, Italy 187 P3.14.24 - Abnormal distribution of B-cells populations associated with impaired regulatory functions in the Chronic Humoral Rejection Alexandre Nouël, I. Segalen, A. Grall, J.O. Pers, Y. Le Meur, S. Hillion; Brest, France 188 P3.14.25 - The autoantibodies to GM-CSF found in pulmonary alveolar proteinosis are generated through somatic mutations Luca Piccoli, D. Corti, I. Campo, M. Luisetti, L. Varani, F. Sallusto, A. Lanzavecchia; Bellinzona, Switzerland 189 P3.14.26 - CD38 and splenic B lymphocytes involvement in autoimmune disease using a murine model for systemic lupus erythematosus H. Romero Ramirez, M. Dominguez Pantoja, A. Dominguez Rívas, L. Santos Argumedo, Juan C. Rodríguez Alba; Xalapa, Veracruz, Mexico 190 P3.14.27 - Generation of autoreactive and poly-reactive antibody producing cells during gamma-herpesvirus infection Shuhei Sakakibara, T. Yasui, T. Minamitani, H. Jinzai, H. Kikutani; Suita, Osaka, Japan 127 Posters - August 24 191 P3.14.28 - B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice Patrizia Scapini, C. Lamagna, M.A. Cassatella, A.L. DeFranco, C.A. Lowell; Verona, Italy 192 P3.14.29 - B-cell delivery of tolerogenic fusion proteins via anti-CD20 targeting A. Zhang, David W. Scott; Bethesda, United States 193 P3.14.30 - CD19 expression on B cells controls type 1 diabetes (T1D) Robyn M. Slattery; Melbourne, Australia 194 P3.14.31 - Limited somatic hypermutation in IgA of transglutaminase 2 specific as well as gluten specific plasma cells of celiac disease intestinal lesions Øyvind Steinsbø, C. Dunand, L. Mesin, M. Huang, M. Ferrer, K. Lundin, J. Jahnsen, P. Wilson, L. Sollid; Oslo, Norway 195 P3.14.32 - Hydrodynamic DNA vaccination for induction of mouse monoclonal antibodies specifically reacting with N-acetylgalactosaminide 2,6-sialyltransferase II (ST6GalNAc II) M. Stuchlova Horynova, Alena Kasperova, Z. Smrzova, E. Weigl, H. Suzuki, J. Novak, M. Raska; Olomouc, Czech Republic 196 P3.14.33 - B cell extrinsic MyD88 and FcR common gamma chain control contraction of the autoreactive extrafollicular B cell response Rebecca A. Sweet, J.L. Cullen, M.J. Shlomchik; New Haven, United States 197 P3.14.34 - Renal Transplant Recipients lack circulating CD19+CD24hiCD38hi Interleukin-10 producing Regulatory B-Lymphocytes Bastian Tebbe, J. Wang, S. Dolff, A. Kribben, P. Hoyer, O. Witzke, A. Hoerning; Essen, Germany 198 P3.14.35 - Endosomal TLR triggering hyperactivates B cells, induces plasma cells differentiation, class switch and immunoglobulin production in Sjögren’s syndrome S. Brauner, M. Kvarnström, L. Folkersen, S. Görgen, K. Brokstad, R. Jonsson, C. Trollmo, V. Malmström, G. Nordmark, Marie Wahren-Herlenius; Stockholm, Sweden 199 P3.14.36 - The role of B cells as antigen presenting cells in allergic inflammation Tomasz Wypych; Bellinzona, Switzerland 200 P3.14.37 - Anti-thrombin antibodies induced by dengue virus with both anti-thrombotic and pro-fibrinolytic activities Trai Ming Yeh; Tainan, Taiwan P4.02 LIVER VIRAL INFECTIONS Session Time: Saturday, August 24, 13:20 - 15:00 201 P4.02.01 - A deficient translocation of CD3ζ, ZAP-70 and Grb2 to lipid raft, as a hallmark of defective adaptive immune response during chronic hepatitis B infection Luisa Barboza, S. Salmen, G. Teran-Angel, D.L. Peterson, L. Berrueta; Mérida, Venezuela, Bolivarian Republic of 202 P4.02.02 - HCV genotype 3 infected patients: Resistant and the relapsers R.S.A. Khan, Qudsia Bashir, H. Bashir, I.A. Khawar, M.A. Rathore, A. Younis, S. Razak; Islamabad, Pakistan 203 P4.02.03 - Possible routes of transmission among HCV infected Pakistani subjects Qudsia Bashir, R.S.A. Khan, H. Bashir, I.A. Khawar, A. Younis, S. Razak; Islamabad, Pakistan 204 P4.02.04 - Surface receptors and cytokines in CD4+ T cells upon HCV core transduction Cecilia Matilde Fernández Ponce, M. Dominguez-Villar, J. Muñoz-Miranda, M. Duran, E. Aguado, F. Garcia-Cozar; Cadiz, Spain 205 P4.02.05 - Cytokine profiles are modulated through the STAT family and define distinct clinical courses during hepatitis A virus infection F.P. Castro-Garcia, G. Escobedo-Melendez, K. Corral, M.A. Sandoval-Hernandez, M. Realpe, S. Roman, Y. Rosenstein, A. Panduro, Nora A. Fierro; Guadalajara, Mexico 206 P4.02.06 - Transcriptome profile of HCV-specific CD8 cells in early HCV infection Paola Fisicaro, V. Barili, B. Montanini, A. Orlandini, E. Negri, F. Bianchi, G. Missale, S. Ottonello, C. Ferrari; Parma, Italy 207 P4.02.07 - The role of Foxp3+ regulatory T cells in the inhibition of an adaptive immune response in a persistent HBV mouse model Yvonne A. Gäbel, L. Huang, N. Garbi, U. Protzer, P. Knolle; Bonn, Germany 208 P4.02.08 - Monoclonal antibodies to various epitopes of HBs antigen inhibit HBV replication Forough Golsaz Shirazi, H. Mohammadi, M. Amiri, K. Singethan, Y. Xia, A. Bayat, M. Bahadori, M. Jeddi –Tehrani, U. Protzer, F. Shokri; Tehran, Iran, Islamic Republic of 128 Posters - August 24 209 P4.02.09 - Impact of cytokines and apoptosis genes polymorphisms on the outcome of hepatitis C virus infection in Tunisian hemodialysed patients Yousr Gorgi, L. Ksiaa Cheikh Rouhou, H. Aouadi, S. Jendoubi Ayed, I. Sfar, T. Ben Abdallah, K. Ayed; Tunis, Tunisia 210 P4.02.10 - Immunogenetic factors of chronic hepatitis C and hepatocellular carcinoma development observed in atomicbomb survivors Tomonori Hayashi, W. Ohishi, K. Imai, K. Yoshida, I. Hayashi, Y. Hu, J. Kajimura, S. Kyoizumi, Y. Kusunoki, K. Nakachi; Hiroshima, Japan 211 P4.02.11 - Prevalence of GBV-C/HGV and HCV among HIV infected populations in South Iran Mohammad Jafari, M. Mohsenzadeh, M.r. Fathi, A. Pirouzi; Shiraz, Iran, Islamic Republic of 212 P4.02.12 - Serum IP-10 profiles over time in treatment-experienced hepatitis C patients treated with a HCV NS3/4A protease inhibitor in combination with peginterferon and ribavirin Susanne Johansson, L. Vijgen, W. Talloen, M. Beumont-Mauviel, M. Peeters, O. Lenz, J. Aerssens; Beerse, Belgium 213 P4.02.13 - Infectious diseases: Viral infections prevalence among gastroenterology patients Iftikhar A. Khawar, R.S.A. Khan, H. Bashir, Q. Bashir, A. Younis, S. Razak; Kampala, Uganda 214 P4.02.14 - TLR-2 promotes both mouse hepatitis virus (MHV) replication and inflammatory responses in hepatocytes leading to fulminant hepatitis C. Bleau, M. Burnette, A. Jacques, M. Samson, C. Piquet-Pellorce, Lucie Lamontagne; Montréal, Canada 215 P4.02.15 - The altered phenotype of CD4+CXCR5+ T cells and B cells is associated with the chronic hepatitis B virus infection Yu Lei, T. Hu, X. Song, M. Chen, Z. Zhou, D. Zhang, H. Hu, P. Hu, H. Ren; Chongqing, China 216 P4.02.16 - Interleukin-6, tumor necrosis factor- and interleukin -10 polymorphisms are associated with the cytokines serum levels of hepatitis C virus infection in Brazilian Population A.M. Tarragô, A.G. da Costa, J.P.D. Pimentel, S. Gomes, P. Lalwani, A.S. de Araújo, R.A. Marie, A.C. Vallinoto, A. Sadahiro, Adriana Malheiro; Manaus, Brazil 217 P4.02.17 - HHV-8 and hepatitis infections in pemphigus Kaouthar Mejri, M. Kallel Sellami, I. Zarraa, L. Laadhar, W. Tombari, M. Mokni, I. Mokhtar, B. Fazaa, M. Zitouni, S. Makni; Tunis, Tunisia 218 P4.02.18 - Epitope mapping and identification of mutated hepatitis B surface antigens by mouse monoclonal antibodies Hamed Mohammadi, F. Golsaz-Shirazi, A. Roohi, M. Amiri, A. Bayat, J. Mahmoudian, M. Jeddi-Tehrani, F. Shokri; Tehran, Iran, Islamic Republic of 219 P4.02.19 - The diverse roles of necroptosis and inflammatory signaling during chronic overwhelming infections Simon P. Preston, G. Ebert, J.P. Cooney, M. Pellegrini; Melbourne, Australia 220 P4.02.21 - Polarized effector function of NK cells in chronic hepatitis C is partially dependent on the IL28B genotype Magdalena Rogalska-Taranta, A.A. Markova, S. Westhaus, S. Lunemann, A. Taranta, V. Schlaphoff, M.P. Manns, M. Cornberg, S. Ciesek, H. Wedemeyer; Hannover, Germany 221 P4.02.22 - Programmed hepatocytes cell death associated with FLIP dowregulation and Bid activation in response to extracellular PreS1/2 Siham Salmen, M.D. Rojas, D.L. Peterson, L. Berrueta; Merida, Venezuela, Bolivarian Republic of 222 P4.02.23 - Detection of hepatitis B virus variants in Tunisian patients Latifa Satouri; Tunis, Tunisia 223 P4.02.24 - The Cytotoxic T Lymphocyte Response to HLA-Cw08-restricted Envelope Epitope in Resolved Hepatitis B Infection Pimpayao Sodsai, A.T. Tan, N. Kirankarn, A. Bertoletti; Bangkok, Thailand 224 P4.02.25 - Association of MICA variants and hepatitis B virus induced hepatocellular carcinoma Hoang V. Tong, N.L. Toan, L.H. Song, T. Bock, P.G. Kremsner, V. TP; Tuebingen, Germany 225 P4.02.26 - Enhancement of anti-HCV T cell immunity by immunization with an adenoviral vector encoding a TLR4-targeted NS3 protein Lorea Villanueva, F. Aranda, A. Pereboev, L. Silva, D. Llopiz, A. Zabaleta, L. Arribillaga, J. Prieto, J.J. Lasarte, P. Sarobe; Pamplona, Spain 226 P4.02.27 - Fulminant hepatitis caused by virus infection was controlled by BTLA signaling Yuzhang Wu, Y. Chen, C. Yang, S. Wu; Chongqing, China 227 P4.02.28 - P300, but not PCAF, collaborates with IRF-1 in stimulating TRIM22 expression, that is independent on its histone acetyltransferase activity Sidong Xiong, B. Gao, W. Xu; Suzhou, Jiangsu Province, China 129 Posters - August 24 228 P4.02.29 - Intrahepatic CXCR3-associated chemokines and circulating autoantibody profiles in patients chronically infected with hepatitis C virus Andy Q. Yu, M. Ghabril, Z. Meng, S. Hu, T. Amet, D. Byrd, J. Lan, N. Chalasani; Indianapolis, United States P4.04 IMMUNITY TO BACTERIAL INFECTION (EXCLUDING MYCOBACTERIA) Session Time: Saturday, August 24, 13:20 - 15:00 229 P4.04.01 - Mice oral immunization against Vibrio cholera: Zot and Ace recombinant proteins used as a subunit vaccine Shaghayegh Anvari, S. Najar Peerayeh, A. Memarian, M. Behmanesh, S.D. Siadat; Gorgan, Iran, Islamic Republic of 230 P4.04.02 - Antibodies against outer membrane proteins of Moraxella catarrhalis and nontypeable Haemophilus influenzae cross-react with various pathogens of human respiratory tract Daria Augustyniak, J. Bonarowska, P. Mackiewicz, Z. Drulis-Kawa; Wroclaw, Poland 231 P4.04.03 - Functionality of cross-reactive antibodies against Moraxella catarrhalis Daria Augustyniak, M. Piekut, G. Majkowska-Skrobek; Wroclaw, Poland 232 P4.04.04 - Secondary bacterial pneumonia following flu infection: Pathogenesis and protective immunity Mariana E. Bernui, H. Shen; Phladelphia, United States 233 P4.04.05 - Induction of Mast Cell Extracellular Traps by intracellular bacteria Marcia Campillo-Navarro, J. Serafín-López, I. Estrada-García, M. González-jimenez, A. Cerbulo-Vazquez, K. Leyva-Paredes, B. García-Pérez, L. Donis-Maturano, S. Estrada-Parra, R. Chacon-Salinas; Mexico city, Mexico 234 P4.04.06 - Plasmin Cleaves Human complement C3b and C5 Proteins in the Presence of Leptospira interrogans Proteins: A New Role of LigA and LigB for complement Immune Evasion Mónica M. Castiblanco-Valencia, T.R. Fraga, L.B. Silva, D. Monaris, P.A.E. Abreu, A.S. Barbosa, L. Isaac; São Paulo, Brazil 235 P4.04.07 - A murine air pouch model to study group A streptococcal pathogenesis and protective immunity Nico Chiappini, A. Seubert, P. Fontani, J.L. Telford, D. Serruto, G. Grandi, I.M. Y Ros, R. Janulczyk; Siena, Italy 236 P4.04.08 - Investigation of innate immunity genes on the japanese oak silkworm, Anthereae yamamai Kwangho Choi, S. Kim, S. Kim, S. Kang, T. Goo; Suwon, Korea, Republic of 237 P4.04.09 - An inhibitor of sirtuin 1 and sirtuin 2, cambinol, impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock Eleonora Ciarlo, J. Lugrin, A. Santos, G. Grandmaison, I. Dos Santos Pinheiro, D. Le Roy, T. Roger; Lausanne, Switzerland 238 P4.04.10 - Study of the impact of Sirtuin 2 knockout on innate immune responses and sepsis Eleonora Ciarlo, J. Lugrin, I. Dos Santos Pinheiro, D. Le Roy, N. Moulan, H. Yamamoto, H. Acha-Orbea, T. Calandra, J. Auwerx, T. Roger; Lausanne, Switzerland 239 P4.04.11 - Immune-response in lesional skin of secondary syphilis Marco Cusini, V. Merlo, L. Corti, R. Gianotti, L. Venegoni, E. Berti; Milan, Italy 240 P4.04.12 - The role of neutrophil extracellular traps (NETs) in the host defense against Gram-negative sepsis (melioidosis) Hanna K. de Jong, G.C.K.W. Koh, T.A.F. Weehuizen, A. Achouiti, F. Stephan, N.P.J. Day, S.J. Peacock, S. Zeerleder, T. van der Poll, W.J. Wiersinga; Amsterdam, Netherlands 241 P4.04.13 - Protease Activated Receptor 4 contributes to host defense in Streptococcus pneumoniae induced pneumonia Sacha F. de Stoppelaar, C. van ‘t Veer, F.E. van den Boogaard, R. Nieuwland, A.J. Hoogendijk, O.J. de Boer, J.J.T.H. Roelofs, T. van der Poll; Amsterdam, Netherlands 242 P4.04.14 - Streptococcus pneumoniae serine protease HtrA, but not SFP or PrtA, is a major virulence factor in pneumonia Sacha F. de Stoppelaar, H. Bootsma, A. Zomer, J.J.T.H. Roelofs, P.W. Hermans, C. van ‘t Veer, T. van der Poll; Amsterdam, Netherlands 243 P4.04.15 - Th9 and Th22 cytokines profiles expressed by TCD4+ lymphocytes activated with different Aggregatibacter actinomycetemcomitans-serotypes Jaime Díaz-Zúñiga, S. Melgar-Rodríguez, C. Alvarez, R. Vernal; Santiago, Chile 244 P4.04.16 - Undernutrition and birth season influence the antibody response to B. pertussis in children of Northern Senegal Lobna Gaayeb; Saint-Louis, Senegal 245 P4.04.17 - Immuno-microbiological aspects of chronic apical periodontitis L.A. Mozgovaya, I.I. Zadorina, L.P. Bykova, Anatoliy P. Godovalov; Perm, Russian Federation 130 Posters - August 24 246 P4.04.18 - Thrombospondin 1 expression in THP-1 cells stimulated with periodontopathic bacteria Misa Gokyu, H. Kobayashi, H. Nanbara, Y. Changchang, Y. Izumi; Tokyo, Japan 247 P4.04.19 - Development of an in vitro infection model for the evaluation of viable, macrophage-engulfed Pseudomonas aeruginosa Laura K. Green, A.C. La Flamme, D.F. Ackerley; Wellington, New Zealand 248 P4.04.20 - Protective immunity of intranasally infected mice with Brucella Melitensis Delphine Hanot Mambres, E. Muraille, J. Letesson; Namur, Belgium 249 P4.04.21 - DAP12 impairs host defense in pneumococcal pneumonia Tijmen J. Hommes, A.A. Anas, M.C. Dessing, C. van ‘t Veer, A. de Vos, T. van der Poll; Amsterdam, Netherlands 250 P4.04.22 - TREM-1 improves host defense in pneumococcal pneumonia Tijmen J. Hommes, M.C. Dessing, M. Colonna, C. van ‘t Veer, A. de Vos, T. van der Poll; Amsterdam, Netherlands 251 P4.04.23 - Immune Evasion by Staphylococcal Superantigen-Like Protein 10 Weilin Hou, D. Patel, R.J. Langley, J.D. Fraser; Auckland, New Zealand 252 P4.04.24 - State of cellular immunity in children with Recurrent Respiratory Tract Infections before and after vaccination Pneumo23 and Influvac Rasima R. Isayeva; Baku, Azerbaijan 253 P4.04.25 - Long-term protective immunity of multi-antigen outer-membrane protein vaccine against Orientia tsutsugamushi WoonHee Jeung, S. Park, H. Chu, I. Cheon, B. Shim, S. Han, C. Yun; Seoul, Korea, Republic of 254 P4.04.26 - Evaluation of antimicrobial effects of Silver, Zinc and Copper nanoparticles on different Bacillus species spores and vegetative cells Roya Khosravi Eghbal, A. Khanafari, A. Akhavan Sepahy; Tehran, Iran, Islamic Republic of 255 P4.04.27 - Differential immune cell responses of infected lung tissues in mice strains with different susceptibility to Legionella pneumophila Seung Min Kim, Y. Yoon, J. Sohn, M. Kim; Seoul, Korea, Republic of 256 P4.04.28 - Poly(I:C) sensitization induces a cytokine imprinting mechanism in dendritic cells and aggravates septic peritonitis Magdalena Kocur, J. Bauer, S. Kropp, S. Scheu; Duesseldorf, Germany 257 P4.04.29 - Cathepsin X inhibitor decrease the production of cytokines and monocyte microparticles on THP-1 macrophage-like cells stimulated with Helicobacter pylori Andreja N. Kopitar, S. Jeverica, J. Kos, A. Ihan; Ljubljana, Slovenia 258 P4.04.30 - Mechanisms underlying bacteria-infected macrophage cell death-mediated IFN-γ production by innate lymphocytes Koichi Kubota; Sagamihara, Japan 259 P4.04.31 - Mechanisms of NK cell-macrophage Bacillus anthracis crosstalk: a balance between stimulation by spores and differential disruption by toxins Mathieu Le Gars, M. Klezovich-Bénard, J. Corre, H. Jusforgues-Salkani, D. Fiole, N. Burjek, J. Tournier, P. Goossens; Paris, France 260 P4.04.32 - Autophagy and cell death pathways in Shigella-infected MoDCs: a difficult choice Luigi Lembo Fazio, A. Hermansson, V. Ciancarella, E. Mileti, G. Fimia, M. Rescigno, M. Bernardini; Rome, Italy 261 P4.04.33 - Group B Streptococcus and Streptococcus suis differently modulate bacterial interactions with dendritic cells and natural killer cells Paul Lemire, D. Roy, M. Segura; St-Hyacinthe, Canada 262 P4.04.34 - Immunoregulative mechanism of the Leydig cell in the infection by expression of IL-1, IL-6, TGF-β, Fas and FasL mRNA Weiyi Li, Y. XI, G. Chen; Shanghai, China 263 P4.04.35 - Differential inflammasome activation in human macrophages between Salmonella Typhimurium and Salmonella Typhi Hsin-Hung Lin, C. Chiu; Taoyuan,, Taiwan 264 P4.04.36 - Oral infection with Brucella abortus 2308 induces systemic activation of B cells, but a downregulation of CD86 in intestine B cells K.E. Pineda-Benito, O. Rodríguez-Cortés, A. Gutiérrez-Hoya, D. Sandoval-Borrego, Rubén López-Santiago; Mexico DF, Mexico 131 Posters - August 24 265 P4.04.37 - The mechanism behind insufficient Streptococcus pyogenes clearance by autophagy in endothelial cells compared to epithelial cells ShiouLing Lu, Y. Lin, T. Yoshimori; NCKU, Tainan, Taiwan; Osaka University, Osaka, Japan 266 P4.04.38 - Detailed antibody-profile of Helicobacter pylori infected individuals revealed by peptide array screening Samuel B. Lundin, K. Thorell, I. Nookaew, T. Perkins; Gothenburg, Sweden 267 P4.04.39 - Mechanism of interleukin (IL)-17A-mediated enhancement of protective immunity against Listeria monocytogenes infection Goro Matsuzaki, Y. Okita, T. Shiono, S. Hamada, M. Umemura; Nishihara, Okinawa, Japan 268 P4.04.40 - PKF, a secreted serine protease, allows Acinetobacter baumannii to evade innate immune responses Larry S. McDaniel, L.B. King; Jackson, United States 269 P4.04.41 - Effect of the stimulation with different serotypes Aggregatibacter actinomycetemcomitans in the activity of the lymphocytes TCD4+ Samanta Melgar-Rodríguez, J. Díaz-Zúñiga, C. Álvarez, R. Vernal; Santiago, Chile 270 P4.04.42 - A neutrophil elastase inhibitor improves LPS-induced acute lung injury in burn-injured mice Hiromi Miyazaki, S. Ono, M. Kinoshita, R. Takahata, A. Kimura, D. Saitoh; Tokorozawa, Japan 271 P4.04.43 - Citrullination and proteolytic processing of chemokines by Porphyromonas gingivalis Eva A.V. Moelants, G. Loozen, A. Mortier, J. Van Damme, W. Teughels, P. Proost; Leuven, Belgium 272 P4.04.44 - Intracellular crosstalk in Wnt5a expression by LPS Hiromi Nanbara, Y. Yoshida, N. Wara-aswapati, T. Nagasawa, H. Kobayashi, Y. Izumi; Tokyo, Japan 273 P4.04.45 - The transformation of subpopulations CD64+CD16-CD32+CD11b+, CD64+CD16+CD32+CD11b+, CD64-CD16+ CD32+CD11b+ of monocytes in premature newborn with congenital pneumonia Irina V. Nesterova, G.A. Chudilova, L.V. Lomtatidze, O. Sapun, R.I. Sepiashvili; Moscow, Krasnodar, Russian Federation 274 P4.04.46 - Gestational hypothyroidism and its effects on the offspring immune response against infection: Evaluation in a murine model of pneumococcal pneumonia Pamela A. Nieto, F.J. Salazar, H.F. Peñaloza, B.M. Schultz, A.M. Kalergis, C.A. Riedel, S.M. Bueno; Santiago, Chile 275 P4.04.47 - Specific pulse-width mild electrical stimulation induces p53 activation via p38 MAPK and ameliorates LPS-induced inflammatory cytokine response R. Fukuda, Kohei Omachi, M.A. Suico, K. Koyama, Y. Kai, S. Matsuyama, K. Mitsutake, S. Morino-Koga, T. Shuto, H. Kai; Kumamoto-si, Japan 276 P4.04.48 - Legionella pneumophila thymidine auxotroph mutant promote a protective immunity dependent on the bacterial Dot/Icm secretion system and Myd88 signaling pathway against Legionella pneumophila flaAMarcelo Pereira, D.S. Zamboni; Ribeirão Preto, Brazil 277 P4.04.49 - A critical role for Interferon-gamma but not IL-17 in staphylococcal superantigen-mediated toxic shock syndrome A. Scheid, A. Tilahun, V. Chowdhary, Govindarajan Rajagopalan; Rochester, United States 278 P4.04.50 - Evaluation of the immune response against Brucella abortus in splenectomized mice Alice B. Rezende, N.N. Neto, O.H.M. Assis, C.S. Miranda, M. Mota, G.C. Macedo, H.C. Teixeira; Juiz de Fora, Brazil 279 P4.04.51 - Physiological significance of the sodium/proline transporter putP of Helicobacter pylori Araceli Rivera-Ordaz, S. Imrich, H. Jung; Martinsried, Germany 280 P4.04.52 - Protection from severe bacterial infection by injections of cytokine-gene transfected cells Tatsuo Saito-Taki, T. Onogawa, H. Kitasato; Sagamihara, Japan 281 P4.04.53 - The scavenger receptor CD36 downmodulates the early inflammatory response while enhancing bacterial phagocytosis during pneumococcal pneumonia Simona Saluzzo, O. Sharif, U. Matt, K. Lakovitz, S. Knapp; Vienna, Austria 282 P4.04.54 - Identification of functional polymorphisms of the macrophage migration inhibitory factor (MIF) gene associated with morbidity and mortality in pneumococcal meningitis and sepsis Athina Savva, M.C. Brouwer, T. Roger, P. Bochud, D. Le Roy, A. van der Ende, D. van de Beek, T. Calandra; Lausanne, Switzerland 283 P4.04.55 - Phagocytic activity in antibiotic and bacteriophage therapy of peritonitis caused by Escherichia coli Ganna Siritsa, O. Kosilova, H. Khidwrbagi; Kharkov, Ukraine 132 Posters - August 24 284 P4.04.56 - Infection with invasive bacterial pathogens triggers distinct Nod-dependent autophagy and cytokine responses Matthew Sorbara, S. Girardin, D. Philpott; Toronto, Canada 285 P4.04.57 - Selective criteria and important features of protective monoclonal antibodies to tetanus toxin Ivana D. Stojicevic, E.M. Marinkovic, I.P. Zivkovic, V.Z. Petrusic, L.A. Dimitrijevic, M.M. Stojanovic; Belgrade, Serbia 286 P4.04.58 - Th1-Th17 cells mediate pelvic pain induced by uropathogenic Escherichia coli Praveen Thumbikat, L. Wong, M. Quick, J.D. Done, A.J. Schaeffer; Chicago, United States 287 P4.04.59 - Anti-alpha toxin mAb promotes both innate and adaptive immune response in a CA-MRSA USA300 mouse dermonecrosis model Christine Tkaczyk, X.P. Yang, M. Hamilton, V. Datta, J. Suzich, C.K. Stover, B.R. Sellman; Gaithersburg, United States 288 P4.04.60 - A novel polarized ex-vivo organ culture model to study gut inflammation and response to probiotics Aikaterini Tsilingiri, M. Rescigno; Milano, Italy 289 P4.04.61 - Study of the development of actinomycetoma during Nocardia brasiliensis infection in mice with partial genetic blockade of eNOS Anna Velia Vázquez-Marmolejo, M. Salinas-Carmona, L. Pérez-Rivera, A. Atilano-Díaz, D. Domínguez-Armendariz, H. Garza-Esquivel, J. López-Ulloa, L. Fernández-Carrizales; Monterrey, Nuevo Leon, Mexico 290 P4.04.62 - Neutrophilic granulocyte subtype recruitment in human peritonitis Sibylle von Vietinghoff, L. Wang, S. Ge, M. Hiss, H. Haller; Hannover, Germany 291 P4.04.64 - Protective immunity against invasive Streptococcus pneumoniae infections by tissue-specific memory Th17 cells Yan Wang, B. Jiang, J.N. Weiser, H. Shen; Philadelphia, United States 292 P4.04.65 - Differential inflammasome activation by Salmonella strains expressing mutant forms of the NLRC4 ligands FliC and PrgJ John A. Wright, S. Man, G. Frazer, C.E. Bryant; Cambridge, United Kingdom 293 P4.04.66 - The effect of dietary oils on citrobacter rodentium induced colitis Xiujuan Wu, A. Hekmatdoost, V. Morampudi, S.M. Innis, K. Jacosbon; Vancouver, Canada 294 P4.04.67 - A mouse model of shigellosis by intraperitoneal infection Jin-Young Yang, S. Lee, M. Kweon; Seoul, Korea, Republic of 295 P4.04.68 - Production and characterization of neutralizing monoclonal antibodies directed against tetanus toxin fragment C Mehdi Yousefi, F. Tahmasebi, V. Younesi, A. Razavi, J. Khoshnoodi, A. Bayat, E. Abbasi, H. Rabbani, M. Jeddi-Tehrani, F. Shokri; Tehran, Iran, Islamic Republic of 296 P4.04.69 - Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production via PI3K/Akt/GSK3β pathway Yuejuan Zheng, Y. Yang, Y. Li, L. Xu, Y. Wang, H. Song, G. Ji, Y. Yu; Shanghai, China 297 P4.04.70 - Anaphylatoxin C5a promotes kidney infection caused by uropathogenic E. coli K. Li, N. Choudhry, Q. Peng, N. Wang, B. Lu, S. Sacks, Wuding Zhou; London, United Kingdom P4.05 IMMUNITY TO MYCOBACTERIAL INFECTION Session Time: Saturday, August 24, 13:20 - 15:00 298 P4.05.02 - Regulation of granuloma formation in response to infection with Mycobacterium tuberculosis Neha Agrawal, U. Ullah, K.V.S. Rao; New Delhi, India 299 P4.05.03 - Role of Oxidative stress associated anemic prevalence among Leprosy Patients Abdul Azeez M. Ahamed, A.M. Pradeep, N. Vetrivel; Madurai, India 300 P4.05.04 - Immunotherapeutic effects of recombinant adenovirus encoding granulocyte-macrophage stimulating-colony factor in experimental pulmonary tuberculosis Francisco-Cruz Alejandro, M. Dulce, X. Zhou, H. Rogelio; Mexico, Mexico 301 P4.05.05 - Clinical isolates of Mycobacterium tuberculosis in Argentina differentially induces respiratory burst via TLR2 and dectin-1 in neutrophils as possible mechanism of immune escape M. Romero, J.I. Basile, B. Lopez, V. Ritacco, L. Barrera, M.C. Sasiain, Mercedes Aleman; Buenos Aires, Argentina 133 Posters - August 24 302 P4.05.06 - P2X7 receptor activation by ATP released from necrotic cells is crucial to severity of tuberculosis caused by hypervirulent mycobacteria Eduardo P. Amaral, M.R.M. Andrade, S.C.M. Ribeiro, V.R. Lanes, F.M. Almeida, E.M. Salles, K.R. Bortoluci, J.M.M. Alvarez, E. Lasunskaia, M.R. D’Império-Lima; Sao Paulo, Brazil 303 P4.05.07 - Mixed DC /macrophage lineage phenotypes in activated lepromatous lesions during reverse reaction Priscila R. Andrade, T.P. Amadeu, A. Miranda, R.O. Pinheiro, J. Nery, E.N. Sarno; Rio de Janeiro, Brazil 304 P4.05.08 - In vitro TLR2 and CD14 gene silencing effect in the control of Mycobacterium tuberculosis infection Alma Y. Arce-Mendoza, F. Hernandez-Cabrera, A.G. Rosas-Taraco; Monterrey, Mexico 305 P4.05.09 - Pilot study: cytokine pattern in children under eight years with pulmonary tuberculosis Mónica Adriana Asturizaga Mallea, D. Correa, A. Escobar-Gutiérrez, Y. Flores-García, L. Pérez-Fernández, F. Cuevas-Schacht; Mexico, Mexico 306 P4.05.10 - Dynamics of the immune response to DosR and Rpf antigens of Mycobacterium tuberculosis in house hold contacts of tuberculosis patients L. Arroyo, B. Ortiz, M. Rojas, L.F. García, T. Ottenhoff, Luis F. Barrera; Medellin, Colombia 307 P4.05.11 - Functional modulation by Cortisol and/or Dehydroepiandrosterone on THP1-derived macrophages infected with Mycobacterium tuberculosis B. Bongiovanni, D. Mata Espinosa, R. Marquez Velasco, O.A. Bottasso, R. Hernandez Pando, María L. Bay; Rosario, Argentina 308 P4.05.12 - Assessment the activity of blood phagocytes at tuberculosis of lungs Olga V. Berdugina, S.N. Skornyakov, I.D. Medvinsky, A.V. Ershova, K.A. Berdugin; Ekaterinburg, Russian Federation 309 P4.05.13 - Immunological assessment of inflammatory reaction at patients with different forms of tuberculosis of lungs Olga V. Berdugina, S.N. Skornyakov, I.D. Medvinsky, A.V. Ershova, K.A. Berdugin; Ekaterinburg, Russian Federation 310 P4.05.14 - Mycobacterium tuberculosis antigen-specific immune responses among tuberculosis lymphadenitis patients Kidist Bobosha, L. Wassie, M. Habtamu, M. Zewdie, J. Hussien, L. Yamuah, A. Aseffa; Addis Ababa, Ethiopia 311 P4.05.15 - Integrin alpha2 beta1 modulates MMP-1 expression in Tuberculosis Sara Brilha, J.C. Porter, H. Zecchini, J.S. Friedland; London, United Kingdom 312 P4.05.16 - Degradation of cholesterol is essential for the pathogenicity of Mycobacterium tuberculosis Marta Brzezinska, I. Szulc, M. Klink, A. Brzostek, M. Kielbik, Z. Sulowska, J. Dziadek; Lodz, Poland 313 P4.05.17 - Granzyme A is an additional marker for tuberculosis (TB) to discriminate between patients with active disease and subjects with latent infection Nadia Caccamo, V. Orlando, M. La Manna, D. Di Liberto, S. Cutrera, F. Dieli, V. Vanini, E. Petruccioli, D. Goletti; Palermo, Italy 314 P4.05.18 - Mycobacterium tuberculosis Beijing induces a tolerogenic phenotype in dendritic cells J. Reyes-Martínez, Alma D Chávez-Blanco, T. Santos-Mendoza, J. Serafín-López, C. Sandoval-Montes, L. Flores-Romo, S. Estrada-Parra, I. Estrada-García, R. Chacón-Salinas; Mexico City, Mexico 315 P4.05.19 - Macrophage exposure to crystalline silica promotes growth of Mycobacterium tuberculosis by deregulating cell death pathways Leslie Chávez-Galán, L. Torre-Bouscoulet, R. Pérez-Padilla, A. Ramírez-Venegas, I. Sada-Ovalle; Distrito Federal, Mexico 316 P4.05.20 - Mycobacterium tuberculosis impairs autophagic flux in human dendritic cells by ESX-1 M. Etna, A. Romagnoli, E. Giacomini, M. Pardini, M. Corazzari, R. Simeone, R. Brosch, G. Fimia, Eliana M. Coccia; Rome, Italy 317 P4.05.21 - Virulence, immunopathology and transmissibility of selected strains of M. tuberculosis from epidemiological studies in Colombia evaluated in a murine model María F. Cornejo, J. Robledo, D. Mata, B. Marquina, J. Barrios, L.F. García; Mexico City, Mexico 318 P4.05.22 - Induction of Transcription Factors involved in T lymphocyte differentiation in BCG vaccinated subjects and pulmonary Tuberculosis patients with antituberculosis therapy Nancy E. Corral-Fernandez, N. Cortez-Espinosa, M. Salgado-Bustamante, S. Romano-Moreno, S.E. Medellín-Garibay, B. Hernández-Castro, J.J. Macias-Mendoza, R. González-Amaro, D.P. Portales-Perez; San Luis Potosí, Mexico 319 P4.05.23 - A partly normalization in the immune-endocrine circulating profile of tuberculosis patients undergoing specific treatment A. Diaz, B. Bongiovanni, L. D’Attilio, N. Santucci, G. Dídoli, S. Radcliffe, N. Brandan, L. Nannini, O.A. Bottasso, Maria Luisa Bay; Rosario, Argentina 320 P4.05.24 - Mycobacterium bovis culture filtrate proteins induces expression of autocrine prolactin loop enhancing inflammatory response in monocytes THP1 Ciro Estrada, G. López, A. Pereira; Guadalajara, Mexico 134 Posters - August 24 321 P4.05.25 - Immunogenicity assessment of live TB vaccine candidates in human primary dendritic cells Marilena P. Etna, E. Giacomini, M. Pardini, M. Severa, D. Bottai, R. Brosch, E.M. Coccia; Rome, Italy 322 P4.05.26 - B cells are important to modulate the immune response against Mycobacterium tuberculosis (Mtb) in mice Isabela C. Fontoura, A. Gembre, É. Padilha, T. Malardo, A.A.M. Coelho-Castelo; Ribeirão Preto, Brazil 323 P4.05.27 - Mycobacterium leprae DNA and cytokine profile of household contacts resident in Governador Valadares, MG, Brazil R.S. Gama, P. Marçal, R. Cypriano, A. Castelo Branco, E.N. Sarno, M.O. Moraes, Lucia A.O. Fraga; Governador Valadares , Minas Gerais, Brazil 324 P4.05.28 - Apoptotic body like liposomes carrying phosphatidic acid enhance antimicrobial and anti-inflammatory innate immune response E. Greco, M.B. Santucci, F. Taus, A. Serafino, A. Ciccaglione, N. Caccamo, R. Nisini, F. Dieli, T.H. Ottenhoff, Maurizio Fraziano; Rome, Italy 325 P4.05.29 - Proteomics reveals dynamic phagosomal environment during Mycobacterium -HIV co-infection Rakesh Ganji, S. Dhali, A. Rizvi, S. Rapole, S. Banerjee; Hyderabad, India 326 P4.05.31 - CD4+ and CD8+ T cells producing IL-17 specific-ESAT-6 or CFP10 M.tuberculosis antigens correlate with therapy successful in MDR-TB patients Yolanda Gonzalez, M.A. Vega Popotla, M. Muñoz-Torrico, M. Salazar Lezama, M. Torres; Mexico City, Mexico 327 P4.05.32 - Attenuation of BCG Delays Cell-to-Cell Spread in the Lung and Promotes its Clearance by T cells Patricia Grace, J. Ernst; New York, United States 328 P4.05.33 - IFN-α adjuvant effect in BCG-vaccinated mice against mycobacterial infections M. Godinez Flores, O. Rojas-Espinoza, S. Giovana, R. Hernandez Pando, L. Gabriele, Gloria G. Guerrero; Zacatecas, Mexico 329 P4.05.34 - Analysis of polymorphisms in TLRs and FcgRs in susceptibility to tuberculosis in a Mexican population Sujhey Hernández Bazán, B. Sánchez, E. Ortega; D. F., Mexico 330 P4.05.35 - Cathepsin S at the crossroads between innate and adaptive immunity to TB infection A. Lau, V. Singh, A. Talal, Zakaria Hmama; Vancouver, Canada 331 P4.05.36 - Prime-boost Mycobacterium smegmatis recombinant vaccination improves protection in mice infected with Mycobacterium tuberculosis by enhancing humoral and cellular specific immune responses Ana Paula Junqueira-Kipnis, F.M. Oliveira, M.M. Trentini, J.A. de Araújo Fliho, A. Kipnis; Goiania, Brazil 332 P4.05.37 - Blockade of PD-1 signal pathway causes exacerbation of Mycobacterium tuberculosis infection via excessive IFN-γ production by antigen-specific Th1 type CD4+ T cells Ikuo Kawamura, M. Mitsuyama; Kyoto, Japan 333 P4.05.38 - Anti-Interferon-Gamma Autoantibodies in Adults with Disseminated Nontuberculous Mycobacterial Infections are Associated with HLA-DRB1*16:02 and DQB1*05:02 and the Reactivation of Latent Varicella-Zoster Virus Infection C. Chi, C. Chu, C. Lin, J. Liu, Cheng- L. Ku; Taoyuan, Taiwan 334 P4.05.39 - Mycobacterium tuberculosis Dos Regulon Gene Rv0079 Encodes a Putative, ‘Dormancy Associated Translation Inhibitor (DATIN)’ and Induce Proinflammatory Responses Ashutosh Kumar, M. Majid, A. Lewin, I.A. Qureshi, N. Ahmed; Hyderabad, India 335 P4.05.40 - Protection evaluation following vaccination with a Mycobacterium abscessus virulence factor in a pulmonary infection cftr-/- mice model Vincent Le Moigne, C. Goulard, B. Barteau, M. Rottman, A. Roux, B. Pitard, J. Herrmann, J. Gaillard; Montigny-le-Bretonneux, France 336 P4.05.41 - Association between DC-SIGN genetic variants and pulmonary tuberculosis in Chinese Uighurs Dan Liu, L. Zhang, C. Peng, Y. Min, H. Wang, H. Wang; Shanghai, China 337 P4.05.42 - Mycobacterium bovis culture filtrate proteins induces expression of autocrine prolactin loop enhancing inflammatory response in monocytes THP1 Gonzalo López, C. Estrada, A. Pereira; Guadalajara, Mexico 338 P4.05.43 - Suppression of immune regulation in a murine model of progressive pulmonary tuberculosis Vasti Lozano Ordaz, M.M.B. Moreno Altamirano, R. Hernandez Pando; México,DF, Mexico 339 P4.05.44 - Reduced frequency of BCG-specific IFN-γ Producing T Cells in Ugandan infants when Bacillus Calmette-Guerin vaccination is delayed from birth to 6 Weeks Of Age Fredrick Lutwama, B.M. Kagina, C. Day, A. Wajja, S. Kirimunda, M. Joloba, P. Musoke, T. Scriba, H. Mayanja-Kizza, W. Hanekom; Cape Town, South Africa 135 Posters - August 24 340 P4.05.45 - Effects of multi-drug therapy (MDT) on cellular immunity in patients with leprosy Patrick Marcinek, T. Engleitner, V. Thirumalaisamy Palanichamy; Tübingen, Germany 341 P4.05.46 - The role of CD137 ligand (CD137L) signaling pathway during M. tuberculosis infection Julia M. Martinez Gomez, V. Koh, W. Lin, M. Ang, Z. Zainul Rahim, H. Schwarz, S. Alonso; Singapore, Singapore 342 P4.05.47 - Prolactin modulate proinflammatory inmune response induced by culture filtrate protein from Mycobacterium bovis in THP1 cells through different signaling pathways Priscila A. Martinez-Neri, G. Lopez-Rincon, J.F. Muñoz-Valle, E.I. Lopez-Pulido, C. Estrada-Chavez, A.L. Pereira-Suarez; Guadalajara, Mexico 343 P4.05.48 - Human memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and are found in a CXCR3+CCR6+ Th1 subset Federico Mele, C. Lindestam Arlehamn, B. Peters, A. Lanzavecchia, A. Sette, F. Sallusto; Bellinzona, Switzerland 344 P4.05.49 - Plasma cytokines and chemokines differentiate between active disease and non-active tuberculosis infection Adane Mihret, Y. Bekele, K. Bobosha, M. Kidd, A. Aseffa, R. Howe, G. Walzl; Addis Ababa, Ethiopia 345 P4.05.50 - Knockdown of suppressor of cytokine signalling 3 mediates killing of Mycobacterium tuberculosis in THP1 derived macrophages Mradul Mohan, A. Misra; Lucknow, India 346 P4.05.51 - Association of SLC11A1 gene polymorphisms with susceptibility to Lepromatous Leprosy Margarita Montoya-Buelna, J. Becerra-Contreras, M. Fafutis-Morris, E. Ochoa-Martínez, T. Reddy, L. Sandoval-Ramírez; Guadalajara, Mexico 347 P4.05.52 - Mycobacterium tuberculosis P27 protein targets host cell mitochondria María M. Bertha M.B. Moreno-Altamirano, C. Espitia, I. Paredes-Gonzalez; Mexico, City, Mexico 348 P4.05.54 - The accumulation of highly differentiated Mtb-specific CD4 T cells is associated with lung tissue destruction during pulmonary tuberculosis Irina Y. Nikitina, A.V. Panteleev, R.B. Amansahedov, V.V. Ganusov, I.A. Vasilyeva, I.V. Lyadova; Moscow, Russian Federation 349 P4.05.55 - Mycobacterium tuberculosis adapts its immune-evasion mechanisms in dependence of the antigen presenting cell and shifting to dormancy Roberto Nisini, M. Pardini, M. Gagliardi, F. Giannoni, F. Lozupone, R. Teloni, M. Fraziano, S. Meschini, S. Mariotti; Rome, Italy 350 P4.05.56 - A novel therapeutic vaccine against tuberculosis using the cynomolgus monkey model and mice Masaji Okada, Y. Kita, S. Hashimoto, H. Nakatani, S. Nishimatsu, Y. Kioka, T. Nakajima, Y. Kaneda, M. Cang, D. McMurray; Sakai, Japan 351 P4.05.57 - Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients Ariane L. Oliveira, T.P. Amadeu, A.C.d. Gomes, V.M. Menezes, J.A.d. Nery, R.O. Pinheiro, E.N. Sarno; Rio de Janeiro, Brazil 352 P4.05.59 - M2-like polarization of Mycobacterium tuberculosis infected human macrophages by extracellular AMP Laetitia Petit-Jentreau, N. Dubois-Colas, L.B. Barreiro, S. Durand, G. Soubigou, K. Rezaï, F. Lokiec, J. Coppée, B. Gicquel, L. Tailleux; Paris, France 353 P4.05.60 - Differences in the levels of host markers detected in saliva and serum and their potential for diagnosing TB disease Khutso G. Phalane, M. Kriel, A.G. Loxton, A. Menezes, K. Stanley, G.D. van der Spuy, G. Walzl, N.N. Chegou; Cape Town, South Africa 354 P4.05.61 - Different immunosuppressive mechanisms in multi-drug-resistant tuberculosis and non-tuberculous mycobacteria patients Roberta O. Pinheiro, E.B. Oliveira, G. dos Santos, G.M. Sperandio da Silva, B.J.A. Silva, A. Milagres, E.N. Sarno, M.P. Dalcolmo, E.P. Sampaio; Rio de Janeiro, Brazil 355 P4.05.62 - Increase of Reactive Oxygen Species in Natural Killer cells from Pulmonary Tuberculosis patients D. Silva, M. Abreu, M. Ferreira-Teixeira, P. Couceiro, I. Ladeira, F. Viveiros, R. Duarte, H. Sá, Paulo Rodrigues-Santos; Coimbra, Portugal 356 P4.05.63 - Fatty acid, cytokines and chemokines profile in exhaled breath condensates (EBCs) of patients with Tuberculosis S. Mosquera-Restrepo, A. Caro-Zapata, C. Peláez-Jaramillo, Mauricio Rojas-Lopez; Medellín, Colombia 357 P4.05.64 - Profiles of fatty acids released during the differentiation of mononuclear phagocytes in the presence of mycobacterium tuberculosis - stearic acid effect on Differentiation A. Caro-Zapata, S. Mosquera-Restrepo, C. Pelaez-Jaramillo, Mauricio Rojas-Lopez; Medellín, Colombia 358 P4.05.65 - The combined use of M. tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active tuberculosis Virginie Rozot, S. Viganò, J. Mazza-Stalder, C. Day, C. Lazor-Blanchet, W. Hanekom, D. Goletti, L. Nicod, G. Pantaleo, A. Harari; Lausanne, Switzerland 136 Posters - August 24 359 P4.05.66 - Functional and phenotypic characterization of Mycobacterium tuberculosis specific CD4+T cells in peripheral blood and at the site of infection Karima Sahmoudi, P. Ndishimye, M. Chair, A. El Habazi, J. Benamour, J. Bourkadi, K. Sadki, O. Lahlou, F. Seghrouchni, R. El Aouad; Rabat, Morocco 360 P4.05.67 - NOD2 triggers an IL-32 dependent human dendritic cell program in leprosy Mirjam Schenk, R.L. Modlin; Los Angeles, United States 361 P4.05.68 - The role of follicular helper T cells in mycobacterial infection Yoko Shimohakamada, T. Tamura, M. Makino, S.L. Nutt; Higashimurayamashi, Japan 362 P4.05.69 - Specific TCD8+IL-10+ and TCD8+TGF-beta+ cells in active tuberculosis patients Bruna Daniella S. Silva, M.M. Trentini, A.C. Costa, A.O. Costa-Júnior, A. Kipnis, A. Junqueira-Kipnis; Goiânia, Brazil 363 P4.05.70 - Deciphering Dendritic Cell Function during Mycobacterium tuberculosis Infection by RNA Interference Jhalak Singhal, K. Natarajan; Delhi, India 364 P4.05.71 - Clinical isolates of Mycobacterium tuberculosis exacerbate pulmonary inflammation in mice Elyara M. Soares, A. Secatto, C. Peres-Buzalaf, E.G. Soares, M. Palaci, C.L. Silva, L.H. Faccioli; Ribeirão Preto, Brazil 365 P4.05.72 - Role of Slc11a1 gene in macrophage activation during BCG infection P. Aguilar-Ramirez, W.H.K. Cabrera, J.R. Jensen, D. Rodriguez, L.C.C. Leite, O.G. Ribeiro, M. De Franco, O.C.M. Ibañez, Nancy Starobinas; São Paulo, Brazil 366 P4.05.73 - Development of a new point-of-care test for leprosy L.P.V. Cardoso, A.A. Freitas, E.M. Hungria, R.M. Oliveira, R.F. Dias, M. Collovati, S.G. Reed, M.S. Duthie, Mariane M. Stefani; Goiania, Brazil 367 P4.05.74 - The involvement of proteins of DNA double-strand breaks repair systems of Mycobacterium tuberculosis in the infection of human macrophages Izabela Szulc, M. Brzezinska, M. Klink, A. Brzostek, M. Kielbik, Z. Sulowska, J. Dziadek; Lodz, Poland 368 P4.05.75 - The role of Mycobacterium tuberculosis secreted protein in the induction of Th1 immune response Toshiki Tamura, Y. Shimohakamada, M. Makino; Higashimurayama, Japan 369 P4.05.77 - The interaction of CD43 with Mycobacterium tuberculosis Cpn60.2 modulates cytokines production Alvaro Torres Huerta, C. Espitia, M.E. Cruz Muñoz, G. Pedraza Alva, Y. Rosenstein; Cuernavaca, Mexico 370 P4.05.78 - Combined detection of IFNγ, TGFα and IL-6 c n discriminate between active TB disease and latent infection Elena Vasilyeva, V. Verbov, I. Nikitina, I. Lyadova, A. Totolian; Saint-Petersburg, Russian Federation 371 P4.05.79 - Modelling human granuloma to study the mechanisms by which isoniazid inhibits Mycobacterium tuberculosis growth Lívia H. Yamashiro, N.M. de Souza, M.D. Garcia, C. Eto, A. Báfica; Florianópolis, Brazil 372 P4.05.80 - Aptamer against an immunosuppressive epitope-ManLAM inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys Xiao-Lian Zhang, Q. Wang, Q. Pan, X. Xia, F. Luo; Wuhan, China P5.09 NEUROIMMUNOLOGY Session Time: Saturday, August 24, 13:20 - 15:00 373 P5.09.01 - Nanotherapy for drug addiction Ravikumar Aalinkeel, J. Reynolds, B. Nair, D. Sykes, W. Law, P. Prasad, S. Schwartz, S. Mahajan; Buffalo, United States 374 P5.09.02 - Immunofluorescence patterns in mouse cerebellum and kidney tissues revealed by seric antibodies of patients with various neuroinflammatory diseases D.L. De la Cruz-Aguilera, J.E. Pablo-Gopar, J.J. Flores-Rivera, T. Corona, A. González-Aguilar, Maria L. Aguirre-Cruz; México D. F., Mexico 375 P5.09.03 - Importance of the vagus nerve in immunodepression following stroke Levent Akyüz, C. Dames, O. Engel, K. Winek, H.D. Volk, C. Meisel, A. Meisel; Berlin, Germany 376 P5.09.04 - Expression of cytokines during the innate immune response in a model of hepatic amoebiasis in sympatectomized hamsters Manuel E. Avila-Blanco, M. Campos-Esparza, M.H. Muñoz-Ortega, A. Quintanar-Stephano, J. Ventura-Juarez; Aguascalientes, Mexico 137 Posters - August 24 377 P5.09.05 - Detection of ANCA (Anti Neutrophil Cytoplasmic Antibodies) by indirect immunofluorescence / ELISA and related neurological diseases: preliminary results on a Moroccan series Siham Aziz, N. Tahiri Jouti, R. Ibn Moufti, H. Fellah, A. Naya, I. Slassi, S. Zamiati; Casablanca, Morocco 378 P5.09.06 - Expression of the galanin system in immune cells: hypothetical key players of the immune response Rodolfo Bianchini, A. Koller, A. Lang, B. Brodowicz, E. Müller, B. Kofler; Salzburg, Austria 379 P5.09.07 - Blocking Glutamate Carboxypeptidase II Inhibited Glutamate Excitotoxicity and Regulated Immune Responses in Experimental Autoimmune Encephalomyelitis So Jin Bing, D. Ha, G. Ahn, J. Kim, J. Cho, S. Ahn Jo, Y. Jee; Jeju, Korea, Republic of 380 P5.09.08 - A new concept to address inflammatory immune activation in neurological disorders Patricia Bolaños, M. Schneider, K. Bechter, P. Walther, H. Raventós; San José, Costa Rica 381 P5.09.09 - Astrocytes play a key role in EAE pathophysiology by facilitating CNS immune cell infiltration and suppressing remyelination Roberta Brambilla, J. Jopek Ashbaugh, P. Morton, S. Karmally, K.L. Lambertsen, J.R. Bethea; Miami, United States 382 P5.09.10 - A single dose of Pirfenidone attenuates neuronal cell death after excitotoxic kainic acid-induced in rat hippocampus through inhibition of microglial activation, but not TNF-ɑ and IL-1β production Rubén D. Castro Torres, V. Chaparro Huerta, M.E. Flores Soto, J. Armendáriz Borunda, C. Beas Zárate; Guadalajara, Mexico 383 P5.09.11 - Increased expression of Toll-like receptors 7 and 9 in Epstein-Barr virus-infected myasthenia gravis thymus Paola Cavalcante, S. Marcuzzo, S. Franzi, L. Maggi, C. Antozzi, F. Baggi, S. Berrih-Aknin, R. Mantegazza, P. Bernasconi; Milan, Italy 384 P5.09.12 - Contact Hypersensitivity To Oxazolone Provokes Vulvar Mechanical Hyperalgesia In Mice Devavani Chatterjea, T. Martinov, R. Glenn-Finer, E. Balsells; Saint Paul, United States 385 P5.09.13 - Expression of dopamine receptor D3 on CD4+ T-cells favors Th1-mediated immunity Francisco Contreras, C. Prado, H. González, D. Franz, D. Elgueta, R. Pacheco; Santiago, Chile 386 P5.09.14 - Prolactin is dispensable for the development of experimental autoimmune encephalomyelitis Massimo Costanza, S. Musio, N. Binart, M. Abou-Hamdan, R. Pedotti; Milano, Italy 387 P5.09.15 - The immunogenicity of amyloid beta oligomers Indre Dalgediene, R. Lasickiene, R. Budvytyte, G. Valincius, R. Morkuniene, V. Borutaite, A. Zvirbliene; Vilnius, Lithuania 388 P5.09.16 - Enhanced susceptibility to pulmonary infections after experimental stroke Claudia Dames, L. Akyüz, O. Engel, K. Winek, H. Volk, A. Meisel, C. Meisel; Berlin, Germany 389 P5.09.17 - Regulatory T cells delay disease progression in a murine model of Alzheimer’s disease Cira Dansokho, C. Toly-Ndour, S. Aïd, T. Chaigneau, M. Holzenberger, P. Aucouturier, G. Dorothee; Paris, France 390 P5.09.18 - Possible role of nerve-glial antigen 2(NG2) in the development of experimental autoimmune encephalomyelitis Giovanni Ferrara, S. Morando, F. Girolamo, M. Errede, N. Kerlero de Rosbo, R. Perris, R. Furlan, C. Bendotti, D. Virgintino, A. Uccelli; Genoa, Italy 391 P5.09.19 - Dopamine regulates the induction of Cytotoxic T-Lymphocyte by stimulation of dopamine receptor D3 expressed on CD8+ T-cells and on dendritic cells Claudio A. Figueroa, F. Contreras, G. Fuentealba, C. Prado, R. Pacheco; Santiago, Chile 392 P5.09.20 - ATP-mediated interaction between astrocytes and T cells Fabia Filipello; Milan, Italy 393 P5.09.21 - Experimental studies of narcolepsy immunopathogenesis in HLA-DQB1*0602 transgenic mice Tobias L. Freitag, K. Zitting, A. Kipar, I. Julkunen, T. Hökfelt, T. Stenberg, S. Meri; University of Helsinki, Finland 394 P5.09.22 - Schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene Hovsep Ghazaryan, A. Boyajyan, R. Zakharyan, A. Melkonyan, Z. Navratilaova, P. Klevcova, M. Petrek; Yerevan, Armenia 395 P5.09.23 - Schizophrenia is not associated with changes in blood expression levels of complement factors B, H and I Hovsep Ghazaryan, A. Boyajyan, R. Zakharyan, A. Melkonyan, Z. Navratilaova, P. Klevcova, M. Petrek; Yerevan, Armenia 396 P5.09.24 - IL-18 and IL-18BP in Amyotrophic Lateral Sclerosis P. Giungato, P. Italiani, P. Migliorini, G. Siciliano, B. Borroni, P. Bossù, Diana Boraschi; Pisa, Italy 138 Posters - August 24 397 P5.09.25 - Using the sodium salt of native DNA as an immunomodulator in the treatment of different diseases Anatoliy P. Godovalov, T.Y. Danielyan, N.A. Danielyan, A.A. Danielyan; Perm, Russian Federation 398 P5.09.26 - Prevalence and evolution of Autoimmune Diseases in patients with Cushing’s Syndrome compared to other Pituitary Tumors: a Multicenter Italian Study Federica Guaraldi, M. De Martin, C. Scaroni, M. Zilio, F. Pecori Giraldi, I. Karamouzis, S. Grottoli, L. Ghizzoni, E. Ghigo, E. Arvat; Turin, Italy 399 P5.09.27 - Measuring cerebrospinal fluid (CSF) immunoglobulins in neurological conditions Yael Hacohen, V. Forsyth, G. Swana, M. Absoud, M. Lim; Oxford, United Kingdom 400 P5.09.28 - Expression of selected Th1/Th2 transcription factors and immune-response genes in cerebral ischemia and senescence Anahit Hakobjanyan, A. Boyajyan, L. Hovsepyan, Z. Navratilova, P. Klevcova, M. Petrek; Yerevan, Armenia 401 P5.09.31 - Regulation of microglia activation mechanisms following chemical or mechanical stimulation Maria Kalognomou, C. Simitzi, I. Athanassakis; Heraklion, Greece 402 P5.09.32 - Macrophage migration inhibitory factor has an essential role in age-related hearing loss Shin Kariya, M. Okano, Y. Maeda, Y. Noyama, T. Haruna, T. Koyama, K. Nishizaki; Okayama, Japan 403 P5.09.33 - Evaluation of multiple sclerosis (MS) based on Antibody to Aquaporine-4(AQP-4) in urine and serum compared to total IgG antibody Afra Khosravi, M. Mohamad-Rashidi; Ilam, Iran, Islamic Republic of 404 P5.09.34 - The inner ear findings in macrophage migration inhibitory factor knockout mice Takahisa Koyama, S. Kariya, M. Okano, Y. Maeda, T. Haruna, Y. Noyama, K. Nishizaki; Okayama, Japan 405 P5.09.35 - Participation of cold sensitive TRPM8 ion channel in modulation of metabolism and immune response Tamara V. Kozyreva; Novosibirsk, Russian Federation 406 P5.09.36 - Chronic co-administration of risperidone (RIS) and fluoxetine (FLU) modulates behavior of mice in forced swimming test (FST) and cytokine production by splenocytes Justyna Kusmierczyk, E. Klimek, A. Roman, Z. Rogoz, I. Nalepa; Krakow, Poland 407 P5.09.37 - High prevalence of anti-neuronal antibodies in Tunisian psychiatric inpatients Lilia Laadhar, O. Sidhom, M. Zitouni, N. Sassi, M. Kallel-Sellami, Z. El Hechimi, S. Makni; Tunis, Tunisia 408 P5.09.38 - Usefulness of pituitary antibodies in the management non-tumoral pituitary diseases in Tunisian adults Lilia Laadhar, M. Chihaoui, M. Kallel-Sellami, N. Sassi, B. Ftouhi, H. Lahmar, F. Kanoun, H. Slimane, S. Makni; Tunis, Tunisia 409 P5.09.39 - Idiopathic hypertrophic cranial pachymeningitis: a rare inflammatory cause of chronic daily headache and progressive cranial neuropathies: a case report Mary Grace B. Laguerta, E.A. Esposo, B. Mariano, M. Martinez; Quezon city, Philippines 410 P5.09.40 - Immune signatures to predict the development and progression of Alzheimer’s disease: lymphocyte profiles Aurélie Y. Le Page, E.H. Frost, G. Dupuis, T. Fülöp; Sherbrooke, Canada 411 P5.09.41 - Patients with febrile infection-related epilepsy and other syndromes and microtubule-associated tau protein data Yevgeniya Lekomtseva, G. Gubina-Vakulik, T. Gorbach; Kharkiv, Ukraine 412 P5.09.43 - Activation of exploratory behavior in senescence accelerated OXYS rats by stimulation of cell-mediated immune response with BCG vaccine Evgeniya V. Markova, N.G. Kolosova, V.A. Kozlov; Novosibirsk, Russian Federation 413 P5.09.44 - Effects of transplantation of the immune cells treated with psycho modulators on the nervous system functional activity of recipients Evgeniya V. Markova, M.A. Knyazheva, V.A. Kozlov; Novosibirsk, Russian Federation 414 P5.09.45 - Characterization and role of the humoral response after transplantation of porcine neuroblasts in the rat brain Elodie Mathieux, V. Nerriere-Daguin, X. Leveque, S. Menoret, I. Anegon, I. Neveu, P. Naveilhan; Nantes, France 415 P5.09.46 - Neuronal toll-like receptor-4 signalling induces brain endothelial cell activation and neutrophil transmigration Samaneh Maysami, S. Leow-Dyke, C. Allen, A. Danes, O. Nilsson, A. Bowie, N. Rothwell, E. Pinteaux; Manchester, United Kingdom 416 P5.09.47 - TLR-2 but not TLR-9 is up-regulated in the Central Nervous System and Lymphoid Organs during Canine Visceral Leishmaniasis Guilherme D. Melo, F.G. Grano, J.E.S. Silva, A. Schweigert, J.R. Peiró, V.M.F. Lima, G.F. Machado; Araçatuba, Brazil 139 Posters - August 24 417 P5.09.48 - Impact of neurturin on allergic airway inflammation in mice M. Mauffray, O. Domingues, J. Zimmer, F. Hentges, D. Hanau, Tatiana Michel; Luxembourg, Luxembourg 418 P5.09.49 - Novel magnetic resonance imaging approaches for monitoring neuroinflammation Jason M. Millward, M. Taupitz, J. Schnorr, S. Wagner, J.T. Wuerfel, K. Riek, J. Braun, F. Paul, I. Sack, C. Infante-Duarte; Berlin, Germany 419 P5.09.50 - A forebrain-immune cell pathway for the maintenance of CNS immune tolerance Mohammad G. Mohammad, V.W.W. Tsai, H. Li, M.G. Hassanpour, S.N. Breit, P.H. Hart, P.E. Sawchenko, D.A. Brown; Sydney, Australia 420 P5.09.51 - Immunomodulatory effects of Interleukin-27 on active experimental autoimmune encephalomyelitis Mohammad S. Mojadadi Mehrabadi, M. Ebtekar, M. Golkar, H. Khan Ahmad; Sabzevar, Iran, Islamic Republic of 421 P5.09.52 - Synaptic deficits in sepsis: Role of glial cells Carolina A. Moraes, G. Santos, J. D’Avila, P. Perdigao, C. Benjamin, F. Bozza, F. Gomes; Rio de Janeiro, Brazil 422 P5.09.53 - Day and Night Alterations of serum melatonin, MIP-1α, MCP-1 and IL-17A levels in multiple sclerosis Ugur Musabak, G. Genc, S. Demirkaya, R.S. Ilikci, O. Kartal, M. Gulec, O. Sener; Etlik, Turkey 423 P5.09.54 - Identifying Biomarkers Associated with Pain in Swine using an In Vitro Inflammation Model C.M. Deaver, E. Kenyon, S.M. Peters, M. Prescott, H.L. Swaim, K. Tanke, H.F. Yancy, Michael J. Myers; Laurel, United States 424 P5.09.55 - Dopamine receptor D3 expressed on CD4+ T-cells favours neurodegeneration of dopaminergic neurons during Parkinson’s disease Rodrigo Pacheco, H. González, F. Contreras, C. Prado, D. Elgueta, D. Franz; Santiago, Chile 425 P5.09.56 - Clinical cases of immune-mediated partial epilepsy Tetiana Pertseva; Kharkiv, Ukraine 426 P5.09.57 - NMR Metabolomics: a Diagnostic Tool for Multiple Sclerosis T. Gebregiworgis, C. Massilamany, A. Gangaplara, H. Nielssen, M. Werth, D. Steffen, R. Zabad, Z. Illes, R. Powers, Jay Reddy; Lincoln, United States 427 P5.09.58 - Influence of LRRK2 G2019 mutation on peripheral B cells from Parkinson’s disease patients Gustavo R. Rossi, M. Kubo, M. Gonçalves, P. Rodrigues-Santos, C. Januário, F. Obata, R. de Carvalho, M. Souto-Carneiro; Curitiba, Brazil 428 P5.09.59 - Anti-ganglioside antibodies in Pandemrix®-induced narcolepsy Anna-Helena Saariaho, O. Vaarala, M. Partinen, S. Meri; Helsinki, Finland 429 P5.09.60 - Effects of vagotomy during inflammation and cytokine production in hamster amebic liver abscess Esperanza Sánchez Alemán, A. Quintanar-Stephano, M. Campos-Esparza, J. Ventura-Juarez; Aguascalientes, Ags., Mexico 430 P5.09.61 - Steroids hormones on neurofibromas development Alessandra Santos, M. Geller, S.G. Mezitis, M. Ribeiro, L. Oliveira, K. Cunha, A. Fonseca, R.S. Batista, A.P. Gomes, G. Darrigo; Rio de Janeiro, Brazil 431 P5.09.62 - Cocaine exposure, abstinence and relapse differentially affect dopaminergic, mu-opioid and CB2 receptors expression on immune cells Raquel Santos-Toscano, A. Higuera-Matas, M. Ucha, D. Roura-Martínez, J. Fernández-Ruiz, M. Miguéns, E. Ambrosio, M.A. Assis; Madrid, Spain 432 P5.09.64 - Immune response in dorsal root ganglion of mice infected with Herpes Simplex-1 (HSV-1) leads to the development of hyperalgesic behaviour Jaqueline R. Silva, A.H.P. Lopes, J. Talbot, R.F.O. França, B.A.L. Fonseca, T.M. Cunha, F.Q. Cunha; Ribeirão Preto, Brazil 433 P5.09.65 - IFN-ɣ is protective in EAE by activating CNS-resident microglia to phagocytose neurotoxic myelin debris Rebecca A. Sosa, A.E. Cardona, T.G. Forsthuber; San Antonio, United States 434 P5.09.66 - Influenza split vaccine in regulation of autoimmune processes in experimental autoimmune encephalomyelitis Aleksandra Stojkovic, D. Kosanovic, N. Vukov, K. Jovanova-Nesic; Belgrade, Serbia 435 P5.09.67 - Evaluation of Tumor necrosis factor (TNF-α) cascade in the brain of rat model of collagen-induced arthritis (CIA) Roba M. Talaat, A.S. Abo-Elatta; Sadat city, Egypt 436 437 140 P5.09.68 - Microglia induced Foxp3+CD4+Treg through PD-L1 in experimental autoimmune encephalomyelitis J. Hu, H. He, G. Zhu, W. Song, B. Bai, Hua Tang; Taian, China P5.09.69 - Gene expression upregulation of TNF superfamily members in temporal lobe epilepsy-associated hippocampal sclerosis Marcelo A. Teocchi, L. D’Souza-Li; Campinas, Brazil Posters - August 24 438 P5.09.71 - The effect of exogenously administered charged microparticles on the acute phase response Shiqing Wang, Y. Couch, G. Bort, B. Davis, D. Anthony; Oxfordshire, United Kingdom 439 P5.09.73 - The function of TREM2 mutants Yoshinori Yamanishi, M. Colonna; St. Louis, United States 440 P5.09.74 - Induction of upregulated expression of histamine receptors and increased release of inflammatory mediators from microglia by histamine Shu Zhang, X. Zeng, S. He; Nanjing, China P5.10 MULTIPLE SCLEROSIS Session Time: Saturday, August 24, 13:20 - 15:00 441 P5.10.01 - The prokineticin system in experimental autoimmune encephalomyelitis: possible novel targets for immune intervention Mhamad Abou-Hamdan, M. Costanza, E. Fontana, M. Di Dario, S. Musio, L. Negri, P. Poliani, C. Farina, G. Balboni, R. Pedotti; Milan, Italy 442 P5.10.02 - Immunopathological patterns in relapsing-remitting and chronic models of experimental autoimmune enchephalomyelitis and the therapeitc effect of glatiramer acetate Rina Aharoni, R. Eilam, R. Arnon; Rehovot, Israel 443 P5.10.03 - Association of SNP rs6897932 in CD127 gene in Relapsing Remitting Multiple Sclerosis (RRMS) patients compared to control group Fereshteh Alesahebfosoul, R. Salehi, A. Zavaran Hosseini, M. Etemadifar, M. Kazemi, M. Tajedin, B. Zarkeshfard; Tehran, Iran, Islamic Republic of 444 P5.10.04 - Frequency of null allele of HLA-G Locus in East Azarbayjan patients with recurrent miscarriage Nazila Alizadeh Gharamaleki; Tabriz, Iran, Islamic Republic of 445 P5.10.05 - Th1/Th17 imbalance in clinical subtypes of Multiple Sclerosis: association with disability and unresponsiveness to IFN-β therapy in relapsing-remitting disease Gabriel Arellano, E. Acuña, L. Reyes, F. Vergara, R. Uribe, E. Ciampi, C. Cárcamo, R. Naves; Santiago, Chile 446 P5.10.06 - The role of STI-571 in the treatment of EAE Gholamreza Azizi, A. Mirshafiey; karaj, Iran, Islamic Republic of 447 P5.10.07 - Interleukin-17A and Interleukin-17F mRNA Expressions in Peripheral Blood Mononuclear Cells of Patients with Multiple Sclerosis Farhad Babaei, Z. Babaloo, M. Farhoodi; Tabriz, Iran, Islamic Republic of 448 P5.10.08 - Inflammatory stimuli and oxidative stress alter mitochondrial transport in neurons Elena Bros, R. Niesner, F. Paul, C. Infante Duarte; Berlin, Germany 449 P5.10.09 - A systems biology approach to identify biomarkers and therapeutic targets in peripheral monocytes of multiple sclerosis patients Ilaria Burba, S. Baldassarri, A. Torri, S. Fumagalli, C. Ripamonti, D. Caputo, M. Rovaris, M. Foti; Milan, Italy 450 P5.10.10 - Micro/nanoparticles platforms for “inverse vaccination” in Experimental Autoimmune Encephalomyelitis (EAE) Giuseppe Cappellano, A. Demeke Woldetsadik, Y. Shivakumar, M. Rizzi, F. Carniato, E. Orilieri, A. Chiocchetti, F. Renò, U. Dianzani; Novara, Italy 451 P5.10.11 - In-vitro up-regulation of Regulatory T cells markers with IFN-beta and c-Phycocyanin: pertinence of a combined treatment for Multiple Sclerosis Majel Cervantes-Llanos, R. Alonso-Ramírez, G. Martínez-Sánchez, J. Cabrera-Gómez, C. Valenzuela-Silva, A. Llópiz-Arzuaga, A. Milian-Jordan, E. De Armas, P. López-Saura, G. Pentón-Rol; La Habana, Cuba 452 P5.10.12 - Complex changes in invariant natural killer T (iNKT) cells in patients with different clinical forms and treatments of multiple sclerosis Sara De Biasi, M. Nasi, A. Simone, D. Ferraro, F. Vitetta, L. Gibellini, M. Pinti, C. Del Giovane, P. Sola, A. Cossarizza; Modena, Italy 453 P5.10.13 - MBP85-99 specific TCR repertoire in DRB1*15 patients affected by Multiple Sclerosis Gabriele Di Sante, S. Rolla, A. Patanella, G. Migliara, A. Piermattei, M. Valentini, A. Batocchi, M. Mirabella, F. Novelli, F. Ria; Rome, Italy 454 455 P5.10.14 - Frequency of Myelin Oligodendrocyte Glycoprotein (MOG) specific B cells in the blood and the CSF of patients with Multiple Sclerosis (MS) Annie Elong Ngono, F. Guillot, A. Garcia, A. Genty, M. Salou, N. Degauque, A. Nicot, S. Brouard, D. Laplaud, J. Soulillou; Nantes, France P5.10.15 - Effector T cell depolarization after glucocorticoid treatment impairs migration and APC conjugate formation Henrike J. Fischer, N. Müller, H.M. Reichardt; Göttingen, Germany 141 Posters - August 24 456 P5.10.16 - The atypical antipsychotic agents, clozapine and risperidone, reduce disease severity in the animal model of multiple sclerosis Laura K. Green, M. Kharkrang, D. O’Sullivan, B. Conner, A.C. La Flamme; Wellington, New Zealand 457 P5.10.17 - Development and assessment of multifunctional gold nanoparticle system for dendritic cell targeting in the treatment of EAE D Haghmorad, M.B. Mahmoudi, M. Hosseini, N. Tabasi, S. Zamani, M. Rastin, M. Mahmoudi; Mashhad, Iran, Islamic Republic of 458 P5.10.18 - 1, 25-dihydroxyvitamin D3 ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice D Haghmorad, M.B. Mahmoudi, A. Amini, N. Tabasi, S. Zamani, M. Rastin, M. Mahmoudi; Mashhad, Iran, Islamic Republic of 459 P5.10.19 - miR-132 suppresses autoimmune encephalomyelitis by inducing cholinergic anti-inflammation: a novel Ahr-based exploration Hamza Hanieh, A. Alzahrani; Alhasa, Saudi Arabia 460 P5.10.20 - Study of the frequency of different CD8+ T cell subsets in patients with Multiple Sclerosis Maryam Izad, Z. Salehi, M. Sahraian, E. Janzamin, R. Doosti, P. Khosravani; Tehran, Iran, Islamic Republic of 461 P5.10.21 - Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms Azam Jamshidian, M. Gharagozloo, V. Shaygannejad, A. Pourazar, S. Zarkesh; Isfahan, Iran, Islamic Republic of 462 P5.10.22 - Vav1 influences susceptibility to central nervous system autoimmunity Sahar Kassem, C. Colacios, A. Dejean, G. J Fournié, B. Malissen, A. Saoudi; Toulouse, France 463 P5.10.23 - Microglia are potent producers of IFNβ in the context of autoimmunity and microbial stimulation Magdalena Kocur, R. Schneider, A. Pulm, J. Bauer, S. Kropp, J. Alferink, T. Prozorovski, O. Aktas, S. Scheu; Duesseldorf, Germany 464 P5.10.24 - Month of Birth, Vitamin D and Risk of Immune Mediated Disease Elham Zare 465 P5.10.25 - NK cells are functionally defective in multiple sclerosis Alice Laroni, R. Gandhi, E. Armentani, I. Gandoglia, F. Ivaldi, G.L. Mancardi, H.L. Weiner, A. Uccelli; Genoa, Italy 466 P5.10.26 - Multiple sclerosis mesenchymal stromal cells exhibit a distinct gene profile and decreased immunosuppressive properties in relation to healthy control cells Gislane Lelis Vilela de Oliveirra, K.C.R. Malmegrim, K.W.A. Lima, D.G. Ribeiro, A. Colombini, D.T. Covas, J.C. Voltarelli, E.A. Donadi; Ribeirão Preto, Brazil 467 P5.10.27 - The regulation synthesis and hydrolysis of cGMP in brain cortex rats during the course of experimental autoimmune encephalomyelitis (EAE) Natalia Lubina-D browska, G. Sulkowski, K. Turska, J. Langfort, A. St pie , M. Chalimoniuk; Warsaw, Poland 468 P5.10.28 - Natural killer cells in early multiple sclerosis Helena Mareckova, L. Skacikova, Z. Hruskova, D. Horakova, E. Havrdova; Prague 2, Czech Republic 469 P5.10.29 - Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling Aram Mokarizadeh; Sanandaj, Iran, Islamic Republic of 470 P5.10.30 - The association of Epstein-Barr virus infection with multiple sclerosis Adeleh Najafipoor, R. Roghanian; Isfahan, Iran, Islamic Republic of 471 P5.10.31 - Monomethyl fumarate induces a switch of activated microglia from a pro-inflammatory to a neuroprotective phenotype Benedetta Parodi, C. Cordano, D. Giunti, C. Usai, N. Kerlero De Rosbo, R.H. Scannevin, A. Uccelli; Genoa, Italy 472 P5.10.32 - Deficiency of CD8 effector memory T cells impairs response to Epstein-Barr virus in multiple sclerosis Michael P. Pender, P.A. Csurhes, C.M.M. Pfluger, S.R. Burrows; Brisbane, Australia 473 P5.10.33 - Investigating the causes of A20 down-regulation in Multiple Sclerosis: genetic mechanisms and hormonal modulations Simona Perga, S. Martire, N.D. Navone, F. Montarolo, P. Berchialla, A. Bertolotto; Orbassano, Italy 474 P5.10.34 - Increased CD8+ T Cell Response to Epstein-Barr Virus Lytic Antigens in the Active Phase of Multiple Sclerosis Eleonora Piras, B. Serafini, C. Gasperini, R. Mechelli, M. Salvetti, D. Centonze, G. Borsellino, F. Aloisi, L. Battistini, D. Angelini; Rome, Italy 475 P5.10.35 - Dysfunction of gene expression in B cells from patients with multiple sclerosis Claudia Policano, V. Annibali, R. Umeton, A. Annese, A. Palermo, R. Mechelli, M. Buscarinu, G. Mattei, G. Ristori, M. Salvetti; Rome, Italy 142 Posters - August 24 476 P5.10.36 - The role of Chlamydia pneumonia in Multiple Sclerosis Maryam Rahimi, R. Roghanian; Isfahan, Iran, Islamic Republic of 477 P5.10.37 - T cell repertoire analyses and comparison between blood, CSF and CNS lesions in patients with Multiple Sclerosis M. Salou, A. Gainche-Salmon, L. Michel, D. Loussouarn, A. Garcia, S. Wiertlewski, J. Soulillou, S. Brouard, N. Degauque, D. Laplaud, Hoa Mai Le; Nantes, France 478 P5.10.38 - Expression of Th1/Th17-related genes in IFN-β-treated relapsing-remitting multiple sclerosis patients Emina Savic, M. Markovic, J. Drulovic, I. Dujmovic Basuroski, S. Mesaros, V. Pravica, D. Popadic, M. Mostarica Stojkovic; Belgrade, Serbia 479 P5.10.39 - The vitamin D and expression of IL-10 and NF-KB genes in Iranian multiple sclerosis patients Zeinab Shirvani Farsani, M. Behmanesh, M. Sahraian, R. Doosti; Tehran, Iran, Islamic Republic of 480 P5.10.40 - Alpha-melanocyte-stimulating hormone (α-MSH) inhibits the development and progression of autoimmune encephalomyelitis by generating functional regulatory T cells Nadine Sucker, L. Klenner, S. Laggies, C. Bürger, T. Luger, K. Loser; Münster, Germany 481 P5.10.41 - Regulatory T-cells in relapsing-remitting multiple sclerosis patients: Effect of disease activity and treatment regimens N. Dimisianos, M. Rodi, D. Kalavrizioti, A. Lastic, P. Sakellaraki, Anthi Tapeinou, T. Tselios, J. Matsoukas, P. Papathanasopoulos, A. Mouzaki; Patras, Greece 482 P5.10.42 - Plasma biomarkers can discriminate among multiple sclerosis clinical forms Marta Tejera-Alhambra, A. Casrouge, C. de Andrés, A. Seyfferth, R. Ramos-Medina, B. Alonso, J. Vega, M. Albert, S. Sánchez-Ramón; Madrid, Spain 483 P5.10.43 - Low DPP4 expression and activity in multiple sclerosis patients Marta Tejera-Alhambra, A. Casrouge, C. de Andrés, R. Ramos-Medina, B. Alonso, J. Vega, M. Albert, S. Sánchez-Ramón; Madrid, Spain 484 P5.10.44 - Andrographolide suppresses chronic and relapsing-remitting experimental autoimmune encephalomyelitis Juan E. Tichauer, E. Molina, E. Acuña, R. Burgos, J. Hancke, C. Cárcamo, R. Naves; Santiago, Chile 485 P5.10.45 - CD28 individual signals amplify pro-inflammatory cytokine production in relapse-remitting multiple sclerosis T lymphocytes Loretta Tuosto, C. Camperio, M. Muscolini, E. Volpe, R. Mechelli, S. Ruggieri, E. Piccolella, M. Salvetti, C. Gasperini, L. Battistini; Rome, Italy 486 P5.10.46 - Antigen-presenting cells in the central nervous system in EAE Agnieszka Wlodarczyk, M. Løbner, O. Cédile, T. Owens; Odense, Denmark 487 P5.10.47 - Transforming growth factor beta and interleukin-10 in multiple sclerosis patients after intravenous infusion of autologous mesenchymal stem cells Marina Zafranskaya, H. Ivanchik, D. Nizheharodava, M. Yurkevich, Y. Motuzova, E. Selezneva, A. Borisov; Minsk, Belarus 488 P5.10.48 - Characterization of immune cell infiltrates in the lesions of multiple sclerosis patients Stephanie E.J. Zandee, M.D. Leech, A. Williams, S.M. Anderton; Edinburgh, United Kingdom 489 P5.10.49 - Activated natural killer T cells recruit myeloid-derived suppressor cells to the central nervous system to suppress multiple sclerosis-like disease Daniel F. Zegarra Ruiz, V.V. Parekh, L. Van Kaer; Lima, Peru P5.22 PRIMARY IMMUNODEFICIENCIES Session Time: Saturday, August 24, 13:20 -15:00 490 P5.22.01 - Identification of B-cell defects using age-defined reference ranges for in-vivo and in-vitro B-cell differentiation Daan J. aan de Kerk, M.H. Jansen, I.J.M. ten Berge, E.M.M. van Leeuwen, T.W. Kuijpers; Amsterdam, Netherlands 491 P5.22.02 - Autoimmune lymphoproliferative syndrome in a patient with homozygous mutation associated to normal Fas expression Nourhen Agrebi, I. Ben Mustapha, M. Medhaffar, M. Ben Ali, B. Larguèche, R. Barbouche; Tunis, Tunisia 492 P5.22.03 - Evaluation of CD4+CD25+FOXP3+ regulatory T cells function in patients with common variable immunodeficiency Nargess Arandi, A. Mirshafiey, M. Jeddi-Tehrani, H. Abolhassani, B. Sadeghi, M. Shaghaghi, A. Aghamohammadi; Tehran, Iran, Islamic Republic of 493 P5.22.04 - AK2 deficiency in zebrafish recapitulates human reticular dysgenesis A. Rissone, J. Jagadeesh, K. Bishop, T. Blake, R. Sood, Fabio Candotti; Bethesda, United States 143 Posters - August 24 494 P5.22.05 - Monoclonal T proliferation associated with a diffuse and invalidant Sezary-like skin-infiltration in a patient with Hyper-IgM syndrome Speranza Antonia Di Maggio, A. Parolo, M. Gazzola, N. Compagno, V. Ferri, R. Scarpa, F. Cinetto, M. Putti, M. Alaibac, C. Agostini; Padova, Italy 495 P5.22.06 - Investigation of ITGB2 gene in 9 Iranian patients with LAD-1 with two new mutations Behnaz Esmaeili, M. Ghadami, M. Fazlollahi, M. Badalzadeh, Z. Alizadeh, L. Atarod, Z. Chavoshzadeh, S. Niroomanesh, Z. Moradi, Z. Pourpak; Tehran, Iran, Islamic Republic of 496 P5.22.07 - Adenosine deaminase deficient severe combined immunodeficiency: evidence from three case reports Ferah Genel, E. Özbek, S. Keskin Gözmen, N. Gülez, O. Tascı, M. Hershfield; Izmir, Turkey 497 P5.22.08 - Plasmablasts in peripheral blood after antigen challenge serve as a diagnostic marker for assessing response to vaccination in CVID patients Ewelina Grywalska, J. Rolinski, A. Surdacka, A. Grafka; Lublin, Poland 498 P5.22.09 - Clinical features and immunological immunophenotyping in Hyper IgE syndrome patients Lucrezia Guadrini, M. Giacomelli, D. Moratto, S. Negri, A. Prandini, R. Kumar, O. Scomodon, A. Plebani, R. Badolato; Brescia, Italy 499 P5.22.10 - Long survival of a patient with IPEX syndrome (Immunodysregulation, Polyendocrinopathy, Enteropathy, X-linked) C. Felice, A. Papa, R. Bacchetta, A. Armuzzi, M. Marzo, G. Andrisani, D. Pugliese, I. De Vitis, G. Rapaccini, Luisa Guidi; Rome, Italy 500 P5.22.11 - Clinical features and immunological abnormalities of GATA2 deficiency in Japan Kenichi Honma, K. Imai, T. Kato, C. Kamae, S. Nonoyama; Tokorozawa, Japan 501 P5.22.12 - GATA 2 transcription factor deficiency predisposing to severe disseminated Coccidioidomycosis Tasnim F. Imran, C. Chongwei; Newark, United States 502 P5.22.13 - Common variable immunodeficiency classification by quantifying T-cell receptor and immunoglobulin κ-deleting recombination excision circles Chikako Kamae, N. Nakagawa, H. Sato, K. Honma, N. Mitsuiki, O. Ohara, H. Kanegane, T. Morio, K. Imai, S. Nonoyama; Tokorozawa, Japan 503 P5.22.14 - Candida antibiotic resistance in Primary Immunodeficiency Disease Samineh Kamali Sabzevari, Z. Pourpak, S. Roodbar Mohammadi, N. Fakhr Mousavi; Tehran, Iran, Islamic Republic of 504 P5.22.15 - Subgroup of Common Variable Immunodeficiency patients with distinct clinical and biological features revealed by B-cell immunophenotyping Veronika Kanderova, E. Fronkova, J. Stuchly, M. Vlkova, I. Hermanova, L. Krol, O. Hrusak, A. Sediva, J. Litzman, T. Kalina; Prague, Czech Republic 505 P5.22.16 - Hax-1 deficiency in Turkish children Sara Sebnem Kilic, O. Gozukmez, D. Hafizoglu, C.Y. Aydogmus, F. Cipe, T. Yakut; Bursa, Turkey 506 P5.22.17 - Investigation on frequency of mutation in the gene segments of immunoglobulin in CD40 knockout mice Yuka Kodera, M. Matsushima, H. Ogiso, N. Ogasawara, K. Takemura, H. Nose, T. Yamaguchi, M. Shiga, T. Kawabe; Nagoya, Japan 507 P5.22.18 - Frequency of lymphomas in a cohort of Common Variable Immunodeficiency (CVID) patients B.C. Sini, Cristina M. Kokron, D. Levy, J. Pereira, A.K.B.B. Marinho, A. Cohon, J. Kalil, S. Bydlowski, M.T. Barros; São Paulo, Brazil 508 P5.22.19 - Genetic analysis of the TNFRSF13B gene in a numerous Italian CVID population Vassilios Lougaris, M. Vitali, M. Baronio, G. Tampella, A. Bergbreiter, U. Salzer, A. Soresina, R. Badolato, A. Plebani; Brescia, Italy 509 P5.22.20 - Hypomorphic mutation in RAG2 gene affects dendritic cell distribution and migration Virginia Maina, V. Marrella, S. Mantero, B. Cassani, E. Fontana, A. Anselmo, A. Del Prete, S. Sozzani, L. Poliani, A. Villa; Milan, Italy 510 P5.22.21 - 8 patients of ataxia-telangiectasia in Azerbaijan Vafa R. Mammadova; Baku, Azerbaijan 511 P5.22.22 - Good’s syndrome: First case report in Algeria Nesrine Messaoudani, R. Djidjik, L. Baough, A. Nekhla, F. Benserai, M. Boubrit, F. Asselah, N. Zidouni, M. Ghaffor; Algiers, Algeria 512 P5.22.23 - Influence of genetic alterations in the WASP gene on the maturation of the B cell compartment D. Moratto, Gaetana Lanzi, L. Gazzurelli, C. Mazza, L.D. Notarangelo, S. Giliani; Brescia, Italy 513 P5.22.24 - A normal T cell receptor beta CDR3 length distribution in patients with APECED Heikki J. Niemi, T. Koivula, S.M. Laakso, P. Arstila, A. Tuulasvaara; Helsinki, Finland 144 Posters - August 24 514 P5.22.25 - Clinical and laboratory evaluation of patients with common variable immunodeficiency before and after immunization with polysaccharide and protein antigens Ana K.B. Oliveira, M. Pedreschi, A. Cohon, G.S. Brito, L.M. Fonseca, J. Kalil, M.T. Barros, C.M. Kokron; São Paulo, Brazil 515 P5.22.26 - Skin sarcoid-like lesions in CVID with poor outcome Roberto Paganelli, M.C. Turi, M. D’Urbano, E. Celletti; Chieti scalo, Italy 516 P5.22.27 - Severe combined deficiency of innate and acquired immunity caused by an IKBKB mutation Ulrich Pannicke, B. Baumann, S. Fuchs, P. Henneke, A. Rensing-Ehl, H. Schrezenmeier, T. Wirth, S. Ehl, M. Schroeder, K. Schwarz; Ulm, Germany 517 P5.22.28 - Reduced NK cell activity and abnormal expression of CCR7 and CXCR1 by NK cells analysis in patients with DOCK8 deficiency Silvia Parolini, G. Tabellini, S. Caracciolo, O. Patrizi, M. Benassi, S. Negri, M. Giacomelli, V. Lougaris, A. Plebani, R. Badolato; Brescia, Italy 518 P5.22.29 - Establishment of newborn screening for SCID / severe T lymphocytopenia in São Paulo Marilia Pyles Patto Kanegae, A. Miyashiro Nunes dos Santos, B. Tavares Costa Carvalho, I. Rugue Genov, A.L. Acquesta; Sao Paulo, Brazil 519 P5.22.30 - Targeted detection of chronic immunodeficiencies by flow cytometry Ulrich Sack, S. Borte, M. Borte, F. Kahlenberg, A. Boldt; Leipzig, Germany 520 P5.22.31 - A New Mutation associated to Bruton Amammaglobulinemia F.R. Mora, R. de la Varga, E. Garcia Moreno, C. Rodriguez, Almudena Sampalo; Cadiz, Spain 521 P5.22.32 - Clinical and Genetic heterogeneity of Chronic Mucocutaneus Candidiasis Disease in four Patients with Heterozygous STAT1 mutations Omar Scomodon, D. Vairo, M. Giacomelli, L. Tassone, G. Maggiore, A. Soresina, V. Lougaris, D. Dinwiddie, S. Kingsmore, R. Badolato; Brescia, Italy 522 P5.22.33 - T regulatory cells and Helios expression in patients with diGeorge syndrome Anna Sediva, K. Sismova, A. Klocperk, J. Grecova, A. Skalicka, R. Zachova; Prague, Czech Republic 523 P5.22.34 - B cell dysregulation in autoimmune lymphoproliferative syndrome Svetlana Sharapova, O. Pashchenko, A. Migas, I. Gyryanova, A. Nevmerzhitskaya, I.V. Kondratenko, M. Belevtsev; Minsk region, Belarus 524 P5.22.35 - Prevalence of Tuberculosis among HIV/AIDS Patients In Obafemi Awolowo University Teaching Hospital Complex (OAUTHC). ILE -IFE Olarinde N. Olaniran 525 P5.22.36 - Antibody deficiency in Ataxia Telangiectasia is caused by disturbed B and T cell homeostasis and reduced immune repertoire diversity G.J.A. Driessen, H. IJspeert, C.M.R. Weemaes, Á. Haraldsson, A. Warris, N. Wulfraat, M. Taylor, J.J.M. Van Dongen, M. van Deuren, Mirjam van der Burg; Rotterdam, Netherlands 526 P5.22.37 - Expression of Bruton’s tyrosine kinase gene and endoplasmic reticulum stress markers in X-linked agammaglobulinemia V.D. Ramalho, M.A. Teocchi, B.M. Abramczuk, T.N. Mazzola, Maria M.S. Vilela; Campinas, Brazil 527 P5.22.38 - Up-regulation of LY6E expression on monocytes attenuates innate immunity by down-regulating CD14 and is associated with HIV disease progression Jianqing Xu, X. Zhang; Jinshan, Shanghai, China 528 P5.22.39 - Lymphoid Intestitial Pneumonia in CVID -oligoclonal expansion of lymphocytes with preferential CMV-specific immune response and lymphorpoliferative disease promotion. Successful rituximab therapy Przemyslaw Zdziarski, A. Lange, D. Dlubek, K. Suchnicki; Wroclaw-46, Poland P6.01 IMMUNOMODULATION BY NUTRIENTS AND VITAMINS Session Time: Saturday, August 24, 13:20 - 15:00 529 P6.01.01 - Vitamin D deficiency increases macrophage polarization and inflammatory infiltrates in epicardial adipose tissue of atherosclerotic swine Devendra K. Agrawal; Omaha, United States 530 P6.01.02 - Impact of zinc supplementation on the production of IL-17 in perinatal stages Ana E. Aguilar, M.T.C. Sanchez, B. Muñoz, R. Pastelin; Mexico DF, Mexico 531 P6.01.03 - Uncaria tomentosa Willd. DC (Cat’s claw) immunostimulatory activity in splenic B lymphocytes D.F. Zegarra Ruiz, Jose L. Aguilar; Lima, Peru 145 Posters - August 24 532 P6.01.04 - Leucocytes and Oxidative Stress by Non-Thermal Plasma Sander Bekeschus, J. Kolata, K. Masur, K. Weltmann, B.M. Bröker; Greifswald, Germany 533 P6.01.05 - The sensitivity to different types of milk in patients with Ulcerative colitis Irina Besu, A. Konic-Ristic, N. Jojic, D. Popovic, Z. Juranic; Belgrade, Serbia 534 P6.01.06 - New therapeutic strategies using xCELLigence system in colon cancer Lorelei I. Brasoveanu, D. Hotnog, I. Iancu, C. Hotnog, A. Botezatu, M. Bostan, M. Mihaila, G. Anton; Bucharest, Romania 535 P6.01.07 - Beta-glucans Uptake by Human Dendritic Cells via a Variety of Endocytotic Mechanisms Jiamin Cao, G.C.F. Chan; Pokfulam, Hong Kong 536 P6.01.08 - Nourishment and its relation with immunitary response and oxidative stress Edelis Catellanos; La Habana, Cuba 537 P6.01.09 - Inflammatory pattern, vitamin D level and cognitive performance in adults and older adults Hala Darwish, S.J. Khoury; Beirut, Lebanon 538 P6.01.10 - Comparative study of the antiinflammatory effect of Inca Inchi oils (Plukenetia volubilis and Plukenetia huayllabambana) Silvia R. Dávila Paico, C. Pitot, D. Zegarra Ruiz, M.A. Cabello Napurí, F. Saldaña Morales, T. Ysmodes Nastasi, Y. Álvarez Valdivia, C. Ocampo Acuña, I. Lozada Requena, J. Aguilar Olano; Lima, Peru 539 P6.01.11 - Iron overload can suppress IL-23 expression from human monocyte-derived dendritic cells and subsequent downstream Th17 expansion C M.A. Dee, K.W. Cheung, J. Shen, G.C.F. Chan; Pokfulam, Hong Kong 540 P6.01.12 - Antioxidant compounds suppress activity of diamine oxidase (DAO) Johanna M. Gostner, K. Becker, F. Überall, D. Fuchs; Innsbruck, Austria 541 P6.01.13 - Ayurvedic myrobalane extracts inhibit LPS-induced tryptophan breakdown in THP-1 cells K. Becker, Johanna M. Gostner, A. Klein, S. Schröcksnadel, B. Magnus, M. Jenny, D. Fuchs, F. Überall; Innsbruck, Austria 542 P6.01.14 - Resveratrol enhances TNF-α production of human monocytes upon TLR-stimulation Guido Gualdoni, J. Kovarik, D. Doberer, F. Dose, P. Steinberger, M. Wolzt, G.J. Zlabinger; Vienna, Austria 543 P6.01.15 - Inhibition of matrix metalloproteinase-9 activity in a leukemic cell line by Mentha spicata extract in vitro Fatemeh Hajighasemi; Tehran, Iran, Islamic Republic of 544 P6.01.16 - Labdane-type diterpene, constituent from myoga which are traditional Japanese food inhibit enzyme activity and gene expression of indoleamine 2,3-dioxygenase 1 Shinjiro Imai, R. Yamamoto, Y. Yamamoto, M. Abe, Y. Ozawa, Y. Katayanagi, T. Nakayama, K. Saito; Suruga-ku, Shizuoka, Japan 545 P6.01.17 - HemoHIM, a novel composition of medicinal herbs, restores the lasting imbalance of Th1- and Th2-related immune response in gamma-irradiated mice and in aged mice Sung-Kee Jo, H. Park, U. Jung; Jeongeup-si, Korea, Republic of 546 P6.01.18 - Implications of the O-GlcNAc modification in the regulation of nuclear apoptosis in T cells Bruno Johnson, J. Bernier; Laval, Canada 547 P6.01.19 - Alliin diminished pro-inflammatory cytokines in supernatants of an in vitro model of adipose tissue Rocio I. Lopez-Roa, S.M. Quintero-Fabian, T.M. Garcia-Iglesias, J.M. Viveros-Paredes, D. Ortuño-Sahagun; Guadalajara, Mexico 548 P6.01.20 - The activity of autoreactive IgG antibodies may be blocked by human serum and breast milk immunoglobulins Iliyan Manoylov, I. Djoumerska-Alexieva, J. Dimitrov, A. Tchrobanov; Sofia, Bulgaria 549 P6.01.21 - Difference in reaction patterns of M1 and M2 macrophages induced by quercetin Miyoko Matsushima, A. Oomura, K. Mori, N. Ogasawara, K. Takemura, H. Nose, T. Yamaguchi, Y. Kodera, M. Shiga, T. Kawabe; Nagoya, Japan 550 P6.01.22 - Expression of cytokines that regulate immune responses in alpaca (Vicugna pacos) blood leukocytes stimulated by clostridial antigens and retinoic acid Juan More Bayona, A. Manchego, K. Chiok, R. Lázaro, N. Sandoval, H. Rivera, M. Ramírez; Lima, Peru 551 P6.01.23 - Expression of humoral and cellular immune response cytokines in alpacas (Vicugna pacos) treated orally with a combination of clostridial antigens and retinoic acid Juan More Bayona, A. Manchego, K. Chiok, D. Pezo, N. Sandoval, H. Rivera, M. Ramírez; Lima, Peru 146 Posters - August 24 552 P6.01.24 - Immune-modulatory properties of cinnamaldehyde are associated with the induction of apoptosis in immune cells Anna Moskovskich, C. Gomez-Casado, A. Willensdorfer, J. Singer, H.C. Fuchs, F. Roth-Walter, E. Jensen-Jarolim; Vienna, Austria 553 P6.01.25 - The effect of quercetin on the activated alveolar macrophages Haruka Nose, M. Matsushima, A. Oomura, K. Mori, N. Ogasawara, K. Takemura, T. Yamaguchi, Y. Kodera, M. Shiga, T. Kawabe; Nagoya, Japan 554 P6.01.26 - Cucumis sativus aqueous extract protects against different metabolic syndrome- associated pathologies Gabriela Rosas, P. Nuñez, A. Arteaga, M. Martínez, C. Trejo, A. Zamilpa, J. Tortoriello, G. Arrelín, E. Jimenez, G. Fragoso; Mexico, Mexico 555 P6.01.27 - Cytoprotective activity of Georgian Red Grapes Extract in mitogen-activated Jurkat cells Tamara Sanikidze, G. Sharashenidze, L. Ratiani; Tbilisi, Georgia 556 P6.01.28 - Chrysin regulates mast cell activation via HO-1-independent pathway Marika Shiga, M. Matsushima, A. Teranishi, H. Nose, N. Ogasawara, K. Takemura, T. Yamaguchi, Y. Kodera, T. Kawabe; Nagoya, Japan 557 P6.01.29 - Methanol extract of Origanum vulgare ameliorates autoimmune diabetes in mice Ivana D. Stojanovic, M. Vujicic, I. Nikolic, V. Kontogianni, P. Charisiadis, A.G. Tzakos, S. Stosic-Grujicic; Belgrade, Serbia 558 P6.01.30 - Evaluation of of crude extracts of sea cucumbers Holothuria lecospilota Genus in persion gulf effects on COX-2 and VEGF genes expression and PGE2, VEGF secretion levels in comparison with celecoxib on colorectal cancer cell line Maryam Taghdiri, A. Khodadadi, M. Assarehzadegan, N. Adibpour; Ahvaz, Iran, Islamic Republic of 559 P6.01.31 - In vitro immunomodulatory and cytoprotective effects of Origanum vulgare methanol extract Milica Vujicic, I. Stojanovic, I. Nikolic, V. Kontogianni, P. Charisiadis, A.G. Tzakos, S. Stosic-Grujicic; Belgrade, Serbia P6.02 METABOLISM AND IMMUNITY INTERFACES Session Time: Saturday, August 24, 13:20 - 15:00 560 P6.02.01 - Evaluation of the relationship between obesity and pro- and anti-inflammatory cytokines in postmenopausal breast cancer patients Rodrigo Andrade, H.C. do Nascimento, A.B. Santana, M.S.C. Gurgel, F.L.P. Costa, S. de Barros-Mazon; Campinas, Brazil 561 P6.02.02 - Arginine depletion during ocular autoimmune responses: in vitro study on bovine explants Houda Belguendouz, K. Lahmar-Belguendouz, L.M. Ahmedi, D. Messaoudene, Z. Djeraba, O.S. Lahlou-Boukoffa, C. Touil-Boukoffa; Algiers, Algeria 562 P6.02.03 - Respiratory complex III (CIII) or Adenin-Nucloeotide Transporter (ANT) inhibition diminishes human monocyte inflammatory capacity Esteban D. Cerezo, L.A. Flores-Mejía, F.J. Sánchez-García, C.R. López-Macías, A. Isibasi, L.A. Arriaga-Pizano; Mexico City, Mexico 563 P6.02.04 - The human intermediate monocyte subset can be further subdivided on the basis of HLA-DR expression revealing a distinct abnormality in obesity and diabetes M. C. Dennedy, E. Connaughton, S. Slevin, S.A. Hanley, T. O’Brien, R. Ceredig, M.D. Griffin; Galway, Ireland 564 P6.02.05 - Clinical-immunological assessment of therapy effect of the neuro-sensory-motor integration program of reflex patterns in airway chronic inflammatory diseases S.K. Masgutova, N.K. Akhmatova, Olga V. Lebedinskaya; Perm, Russian Federation 565 P6.02.06 - Diet enriched with small carbohydrate and saturated fat is able to alter immunological parameters in C57BL/6 mice M.C.G. Miranda, J.L. Goncalves, T.G. Moreira, L.G. Teixeira, A.L. Souza, D.C. Cara, Tatiani U. Maioli, A.C. Faria; Belo Horizonte, Brazil 566 P6.02.07 - Macrophages, but not adipocytes, express TNFa in diet induced visceral obesity Marcia F. McInerney, L.A. Ebke, B. Slotterbeck, A.L. Nestor-Kalinoski, A.G. Al Dieri, S. Ghosh, S.M. Najjar, H. von Grafenstein; Toledo, United States 567 P6.02.08 - Activation markers show greater expression on adipose tissue resident T-lymphocytes with increased adiposity R. Travers, Alexandre C. Motta, J. Betts, D. Thompson; Vlaardingen, Netherlands 568 P6.02.09 - Galectin-3 deficiency accelerates high-fat diet induced obesity and diabetes by amplifying metaflammation Nada Pejnovic, J. Pantic, I. Jovanovic, G. Radosavljevic, M. Milovanovic, I. Nikolic, N. Zdravkovic, A. Djukic, N. Arsenijevic, M. Lukic; Kragujevac, Serbia 569 P6.02.10 - P2X7 receptor expression and potential role in T cells in Type 1 Diabetes Lisa Perruzza, F. Grassi; Bellinzona, Switzerland 570 P6.02.11 - Insulin resistant obese individuals have increased frequency of CD14++CD16+ monocytes, what is modulated by a bout of aerobic exercise Etel Rocha-Vieira, M. Matos, T. Duarte, V. Ottone, K. Costa, G. Brito-Melo, F. Amorim; Diamantina, Brazil 147 Posters - August 24 571 P6.02.12 - The regulatory role of amino acids in the immune response Nataliya Salyha; Lviv, Ukraine 572 P6.02.13 - The peptide hormone Insulin-like growth factor-1 affects the immune system during physiological and pathological inflammatory responses Susanne Sattler, B. Johannesson, J. Tonkin, E. Gallego-Colon, D. Bilbao, E. Semenova, N. Rosenthal; London, United Kingdom 573 P6.02.14 - Unsuspected relationship between Ferritin Heavy Chain and NK cells tumor susceptibility Rosa Sottile, F. Santoro, C.M. Faniello, C. Garofalo, R. Tallerico, F.S. Costanzo, E. Carbone; Catanzaro, Italy 574 P6.02.15 - Modulation of lipid metabolism and colon cancer cell growth by Cyclosporin A Miriam B.F. Werneck, M.C. Augustin, J.P.B. Viola, P.T. Bozza; Rio de Janeiro, Brazil 575 P6.02.16 - Enhanced glycogen synthase kinase 3beta phosphorylation modulates leukocyte Toll-like receptor-mediated cytokine secretion in obesity Chia-Liang Yen, C. Chang, C. Wu, C. Shieh; Tainan, Taiwan P6.06 CANCER IMMUNOTHERAPY AND ANTI-TUMOR VACCINES Session Time: Saturday, August 24, 13:20 - 15:00 576 P6.06.001 - Inhibitory effects of single chain fragment variable (scFv) antibodies against prostate stem cell antigen (PSCA) on prostate and pancreatic cancer cell lines Soghra Abdi, F. Nejatollahi; Ilam, Iran, Islamic Republic of 577 P6.06.003 - GMP-production of an allogenic DC-based cancer vaccine (COMBIG-DC) for treatment of patients with metastatic renal cancer using the ELUTRA Platform Lars Adamson, R. Kiessling, B. Andersson, B. Näsman-Glaser, A. Karlsson-Parra; Stockholm, Sweden 578 P6.06.004 - Breast cancer immunopathology to immunotherapy in Northern Emirates of the United Arab Emirates Mohamad Alhomssi, A. Mohamad, H. Hamdy; Sharjah, United Arab Emirates 579 P6.06.005 - Generation and characterization of a new chimeric antibody against Her2 Mohammad M. Amiri, M. Jeddi-Tehrani, M. Bahadori, M. Hojjat-Farsangi, J. Khoshnoodi, H. Rabbani, F. Shokri; Tehran, Iran, Islamic Republic of 580 P6.06.006 - Annexin A2 is a Glioma Damage-Associated Molecular Pattern Enriched in Physiologic Oxygen Brian M. Andersen, M.R. Olin, C.E. Seiler, X. Junzhe, A.L. Epstein, W. Chen, B.R. Blazar, J.R. Ohlfest; Minneapolis, United States 581 P6.06.007 - MHC I multimer assay: Optimized double staining for improved sensitivity in detection of low affine CD8+ antigen-specific T cells by flow cytometry Stig Henrik Andersen, K. Jacobsen, L. Brix, H. Pedersen; Copenhagen, Denmark 582 P6.06.008 - Increased efficacy of dendritic cells by protein components compared to total extract of Listeria monocytogenes in experimental tumor Immunotherapy Samaneh Arab, M. Motamedi, J. Hadjati; Tehran, Iran, Islamic Republic of 583 P6.06.009 - Green tea polyphenols modulate certain indices of nonspecific anticancer resistance Anna B. Artamonova, S.P. Zaletok, O.V. Karnaushenko, A.V. Verbinenko; Kyiv, Ukraine 584 P6.06.010 - Polysaccharides of the Lentinus edodes modulate certain indices of specific anticancer resistance Anna B. Artamonova, V.O. Shlyakhovenko; Kyiv, Ukraine 585 P6.06.011 - Anti-Metastatic Effect of Anti-HER2 scFv Antibodies on Breast Cancer Cells Mahdi Asgharpour, F. Nejatollahi; Shiraz, Iran, Islamic Republic of 586 P6.06.012 - ImmTACs: bi-specific TCR-anti-CD3 fusions for potent re-directed killing of cancer cells Rebecca Ashfield, G. Bossi, D. Baker, J. Harper, J. Dukes, N. Liddy, Y. McGrath, A. Vuidepot, N. Hassan, B. Jakobsen; Abingdon, Oxfordshire, United Kingdom 587 P6.06.013 - Oroxylin A affects frequency and function of myeloid-derived suppressor cells in experimental model of cancer Mahboubeh Ashourpour, A. Namdar, J. Hadjati; Tehran, Iran, Islamic Republic of 588 P6.06.014 - T cell tolerance as function of tumor progression Meir Azulay, E. Tzehoval, E. Vadai, L. Eisenbach; Rehovot, Israel 589 P6.06.015 - TLR3/BATF3 axis in CD8α+DC induces anti-tumor CTLs by dsRNA Masahiro Azuma, M. Matsumoto, T. Seya; Sapporo, Japan 148 Posters - August 24 590 P6.06.016 - Anti-tumor effects of heat shock proteins, Bacillus Calmette-Guérin, angiogenesis inhibitor, Bifidobacterium and Immuno-Modulator Drug on fibrosarcoma in mice Behzad Baradaran, J. Majidi, T. Kazemi, L. Aghebati, M. Orangi; Tabriz, Iran, Islamic Republic of 591 P6.06.017 - Maternal immunization: transfer of a protective anti-tumor immunity from mothers to the offspring; a first evidence Giuseppina Barutello, M. Arigoni, C. Curcio, M. Spadaro, R. Clynes, R. Trovato, E. Bolli, F. Riccardo, F. Ria, F. Cavallo; Torino, Italy 592 P6.06.018 - The peripheral blood compartment of patients with Diffuse Large B Cell Lymphoma (DLBCL) at diagnosis is characterized by distinct phenotypic and functional Immunological alterations Simone Battella, S. Pelliccia, R. La Scaleia, A. Di Napoli, A. Porzia, L. Ruco, F. Mainiero, A. Santoni, M.C. Cox, G. Palmieri; Rome, Italy 593 P6.06.019 - Adenosine receptor blockade potently suppresses the metastasis of CD73+ tumours Paul A. Beavis, U. Divisekera, C. Paget, M.T. Chow, L.B. John, J. Stagg, M.J. Smyth, P.K. Darcy; Melbourne, Australia 594 P6.06.020 - Development of a DC-based therapeutic vaccine for AML patients: characterization of GMP-grade TLR-agonist matured 3-day DCs expressing the leukemia-associated antigens WT1 and PRAME Barbara Beck, C. Geiger, I. Bigalke, F.S. Lichtenegger, G. Kvalheim, M. Subklewe, D.J. Schendel; Munich, Germany 595 P6.06.021 - Development of new therapeutic antibodies formats directed against the folate receptor alpha Davide Bernareggi, E. Luison, A. Satta, B. Frigerio, M. Colombo, S. Canevari, M. Figini; Milan, Italy 596 P6.06.022 - Toxoplasma gondii protein fractions for the generation of dendritic cell based cancer vaccine Roobina Boghozian, A. Saei, R. Mirzaei, J. Hajati; Tehran, Iran, Islamic Republic of 597 P6.06.023 - Comparison of DNA-based vaccine and non-pathogenic live vaccine strategies using the mini-chaperones for the prevention of HPV16 E7-overexpressing cancers Azam Bolhassani, S. Hosseinzadeh, A. Daemi; Tehran, Iran, Islamic Republic of 598 P6.06.024 - Antitumor potential of novel betulin derivative on human A375 melanoma cells Mirna Bulatovic, M. Mojic, G. Kaluderovic , D. Miljkovic , S. Stosic -Grujicic , R. Paschke, S. Mijatovic , D. Maksimovic -Ivanic ; Belgrade, Serbia 599 P6.06.025 - Early growth response gene 2 acts as an intrinsic negative regulator of DC immunogenicity M.A. Miah, Se Eun E. Byeon, Y.S. Bae; Suwon, Gyeonggi-do, Korea, Republic of 600 P6.06.026 - ENO1-DNA vaccine significantly delays pancreatic tumor progression by eliciting complement-dependent cytotoxicity Paola Cappello, S. Rolla, R. Curto, E. Tonoli, M. Principe, H. Carnevale, M. Giovarelli, F. Novelli; Torino, Italy 601 P6.06.027 - Enrichment of KIR+CD57+ highly cytotoxic NK cells in sentinel lymph nodes of melanoma patients Ennio Carbone, T. Hassan Ali, S. Pisanti, E. Ciaglia, R. Mortarini, A. Anichini, M. Santinami, E. Gulletta, C. Ietto, M. Galgani; Catanzaro, Italy 602 P6.06.028 - Multiple Myeloma cells in Vk*MYC mice are highly susceptible to WT1 and MAGE-A specific cytotoxic T lymphocytes Elena Cattaneo, A. Calcinotto, M. Grioni, A. Gasparri, M. Bianco, S. Bertilaccio, M. Chesi, L. Bergsagel, A. Corti, M. Bellone; Milan, Italy 603 P6.06.029 - Vaccination with human CSPG4 DNA induces an anti-tumor antibody response and prolongs survival in dogs with oral malignant melanoma F. Riccardo, S. Lorda Mayayo, S. Prestigio, S. Iussich, G. La Rosa, R. De Maria, S. Ferrone, P. Buracco, Federica Cavallo; Torino, Italy 604 P6.06.030 - Correlation between the high expression of cancer testis antigens and the prognosis in patients with esophageal carcinoma in China Xin-Feng Chen, J. Liu, M. Wang, Y. Zhang; Zheng Zhou, China 605 P6.06.031 - CD38 immunotherapy: killing two birds with one stone Antonella Chillemi, V. Quarona, G. Zaccarello, M. Ferracin, C. Ghimenti, A. Zito, M. Massaia, A.L. Horenstein, F. Malavasi; Torino, Italy 606 P6.06.032 - Combination immunotherapy with tumor-specific CD4+ and CD8+ T cells decreases CD8+ T cell exhaustion and augments therapeutic efficacy Sarah E. Church, S.M. Jensen, B.A. Fox; Portland, United States 607 P6.06.033 - A new pathway of tumor antigen loading of human dendritic cells via intercellular communication Mariarosa Ciranna, L. Morelli, C. Pozzi, G. Penna, M. Rescigno; Milan, Italy 608 P6.06.034 - A phase Ib clinical trial of cisplatin and pemetrexed in combination with the CD40 activating antibody CP-870,893 A. McDonnell, Alistair Cook, B.W.S. Robinson, R.A. Lake, J. Creaney, A. Hasani, M. Millward, A.K. Nowak; Perth, Australia 149 Posters - August 24 609 P6.06.035 - Optimising regulatory T cell (Treg) depletion in combination with chemotherapy for enhanced anti-tumour immunity Alistair Cook, B. Robinson, A. McDonnell, M. Millward, R.A. Lake, A.K. Nowak; Perth, Australia 610 P6.06.036 - Radiation therapy plus IL-2 in patients with metastatic melanoma is associated with release of danger associated molecular patterns when compared to IL-2 alone but not an increase in circulating inflammatory cytokines Marka R. Crittenden, M. Gough, B. Fox, S. Seung, B. Cottam, J. Walker, W. Urba, B. Curti; Portland, United States 611 P6.06.037 - RIL-21 combined with CD4-T cell depletion reprograms CD4+ T cells from an immune regulatory to an anti-tumor phenotype in syngeneic neuroblastoma Michela Croce, A. Brizzolara, V. Rigo, A. Orengo, B. Carlini, M. Corrias, S. Ferrini; Genoa, Italy 612 P6.06.038 - Pre-clinical development of an agonistic CD40 antibody (ADC-1013) for local immunotherapy of cancer Eva Dahlén, C. Furebring, S. Broos, T. Berggård, P. Norlén, M. Lindstedt, T. Tötterman, S. Mangsbo, P. Ellmark; Lund, Sweden 613 P6.06.039 - Th1/Th2/Th17 profile and T cell phenotype of an in vitro antigen presentation system in response to DC functionality, IL-2 and IGF-1 presence Anne-Lise de Lastic, M. Rodi, A. Mouzaki; Patras, Greece 614 P6.06.040 - The predictive role of αβ-double negative T cells in clinical outcome of patients with lymphoma: preliminary data Giacoma De Tullio, C. Minoia, S. Serratì, F. Merchionne, G. Loseto, A. La Pietra, A. Rana, A. Iacobazzi, P. Iacopino, A. Guarini; Bari, Italy 615 P6.06.041 - Deciphering adaptive anti-tumor immunity induced by anti-CD20 mAb treatment Claire Deligne, A. Metidji, J. Teillaud; Paris, France 616 P6.06.042 - The tumor microenvironment can vary with anatomical site to affect responses to therapy Christel Devaud, J.A. Westwood, L.B. John, J.K. Flynn, S. Paquet-Fifield, M.J. Smyth, P.K. Darcy, M.H. Kershaw; East Melbourne (VIC), Australia 617 P6.06.043 - Antitumor activity of PEGylated Fab-fragments of GD2-specific antibody Igor I. Doronin, I. Kholodenko, I. Molotkovskaya, R. Kholodenko; Moscow, Russian Federation 618 P6.06.045 - Chimeric protein of IL-2 linked to light chain of anti-IL-2 mAb S4B6 that structurally mimics IL-2/S4B6 immunocomplexes: design and production Barbora Dvorakova, J. Tomala, J. Kovarova, M. Kabesova, P. Votavova, H. Chmelova, B. Rihova, M. Kovar; Prague, Czech Republic 619 P6.06.046 - Enhanced efficacy of a cancer vaccine by blocking TGF-β-dependent induction of regulatory T cells with a retinoic acid receptor-α antagonist Lydia Dyck, K.C. Galvin, K.H.G. Mills; Dublin, Ireland 620 P6.06.047 - Lymphocyte imprinting with melanoma antigens acquired by trogocytosis facilitates identification of tumor-reactive T cells Galit Eisenberg, R. Uzana, A. Pato, S. Frankenburg, S. Merims, E. Yefenof, S. Ferrone, T. Peretz, M. Lotem, A. Machlenkin; Jerusalem, Israel 621 P6.06.048 - Inhibition of intercellular communication between prostate cancer cells by anti-STEAP-1 single chain antibody Alireza Esmaili, F. Nejatollahi; Shiraz, Iran, Islamic Republic of 622 P6.06.049 - Soluble MICA serum levels as predictive biomarkers of anti-CTLA-4 melanoma immunotherapy Joana Felix, R. Porcher, C. Pages, I. Sidina, V. Kheav, G. Maki, M. Viguier, A. Toubert, C. Lebbe, H. Moins-Teisserenc; Paris, France 623 P6.06.050 - Bispecific single-chain diabodies for T cell retargeting to solid tumors Sina Fellermeier, R.E. Kontermann; Stuttgart, Germany 624 P6.06.051 - Natural Killer adoptive cell transfer targeting bladder cancer stem cells: preliminary results for fine-tuning strategy Margarida Ferreira-Teixeira, B. Parada, F. Reis, C. Gomes, P. Rodrigues-Santos; Coimbra, Portugal 625 P6.06.052 - A Dendritic Cell (DC) microRNA signature predicts clinical outcome in Melanoma Patients treated with DC vaccine Laura Fiammenghi, E. Bandini, F. Fanini, M. Petrini, E. Pancisi, A.M. Granato, V. Ancarani, L. Ridolfi, M. Guidoboni, M. Fabbri; Meldola, Italy 626 P6.06.053 - Anti folate receptor Ab conjugated iron-oxide nanoparticles for tumor localization in an ovarian cancer models Mariangela Figini; Milan, Italy 627 P6.06.054 - Combining prime-boost anti-tumour vaccination with debulking surgery for the treatment of solid tumours Scott A. Fisher, A. Cleaver, A. Khong, T. Connor, B. Wylie, D. Lakhiani, C. Boylen, B.W.S. Robinson, R.A. Lake; Perth, Australia 150 Posters - August 24 628 P6.06.055 - Anti-PSMA scFv as theranostic tool for prostate cancer Barbara Frigerio, E. Luison, A. Satta, D. Bernareggi, F. Caroli, E. Bombardieri, G. Fracasso, S. Canevari, M. Figini; Milan, Italy 629 P6.06.056 - Generation of EBV/CMV bi-specific T cells using retroviral T cell receptor (TCR) gene transduction for adoptive immunotherapy Ahmed Z. Gad, X. Liang, A. Moosmann; Munich, Germany 630 P6.06.057 - Sub-lethal irradiation of human colorectal carcinoma cells imparts enhanced and sustained expression of important modulators of effector CTL activity Charlie Garnett-Benson, A. Kumari; Atlanta, United States 631 P6.06.058 - Differential regulation of B-cell proliferation by IL21 in different subsets of chronic lymphocytic leukemia Ghasem Ghalamfarsa, F. Jadidi-Niaragh, M. Hojjat-Farsangi, M. Yousefi, S. Razavi, A. Saboor-Yaraghi, H. Rabbani, M. Jeddi-Tehrani, F. Shokri; Tehran, Iran, Islamic Republic of 632 P6.06.059 - Lysis-on-chip of single cells after programmed interaction with cytotoxic T-lymphocytes (CTLs) or natural killer (NK) cells on a dielectrophoresis (DEP) based array M. Abonnenc, M. Borgatti, F. Destro, N. Manaresi, G. Medoro, E. Lo Monaco, Patrizio Giacomini, R. Guerrieri, R. Gambari; Rome, Italy 633 P6.06.060 - Anticancerogenic and immunotropic properties of GA-40 preparation Alexsidze Giorgi; Tbilisi, Georgia 634 P6.06.061 - Chronic exhaustion of tumor-specific CD4+ T cells leads to recurrence of melanoma Stephen R. Goding, K.A. Wilson, K.M. Harris, P.A. Antony; Baltimore, United States 635 P6.06.062 - Effect of polychemotherapy on leukocytes under acute lymphoblast leukosis in children O.V. Lebedinskaya, N.B. Merzlova, Anatoliy P. Godovalov, I.A. Baranova, A.V. Proskuryakov; Perm, Russian Federation 636 P6.06.063 - Identification and validation of hypoxia-specific tumor associated antigens in prostate cancer T. Ma, A. Elkhattouti, S. Vuk-Pavlovi , Christian R. Gomez; Jackson, United States 637 P6.06.064 - A melanoma cell lysate induces CCR7 expression on human dendritic cells and its in vivo migration to draining lymph nodes Fermín González; Santiago, Chile 638 P6.06.065 - Low-dose conventional chemotherapeutics synergizes with dendritic cell - based immunotherapy in antitumor activity Alexander I. Gorbach, N.M. Khranovska, V.K. Pozur, O.V. Skachkova, N.M. Svergun, R.I. Sydor, V.V. Nikulina; Kyiv, Ukraine 639 P6.06.066 - Targeting effector CD8 T cells to the tumor using high dose radiation therapy in mice Michael Gough, K. Young, B. Cottam, T. Savage, P. Newell, K. Bahjat, M. Crittenden; Portland, United States 640 P6.06.067 - Vaccination with autologous glioma lysate induces tumor-reactive IgG antibody response and increases survival in dogs with glioma Michelle R. Goulart, B.M. Andersen, C.E. Seiler, M.A. Hunt, M.G. O’Sullivan, C. Johnson, Z. Zhang, J.R. Ohlfest, G.E. Pluhar; St. Paul, United States 641 P6.06.068 - “First AID” for T cell adoptive transfer: TCR affinity maturation by somatic hypermutation Yosi M. Gozlan, E. Tzehoval, L. Eisenbach; Rehovot, Israel 642 P6.06.069 - HPV-derived T-helper epitopes for therapeutic HPV vaccine design Agnieszka K. Grabowska, S. Hoppe, R. Blatnik, A.B. Riemer; Heidelberg, Germany 643 P6.06.070 - CpG-activated pDCs contribute as APCs in the generation of Th17 cells that control tumor growth Leslie Guery, J. Dubrot, C. Lippens, D. Brighouse, M. Irla, W. Reith, J. Waldburger, S. Hugues; Geneva, Switzerland 644 P6.06.071 - Role of B cells in anti-tumour immunity Thomas V. Guy, A.J. Buckley, J. Holst, R. Brink, B. Fazekas de St Groth, E. Shklovskaya; Sydney, Australia 645 P6.06.072 - Comparison of monocyte derived dendritic cells versus leukemic blasts derived dendritic cells for immunotherapy of AML Jamshid Hadjati, F. Masoumi, M. Nourizadeh, R. Mirzaei; Tehran, Iran, Islamic Republic of 646 P6.06.073 - IMCgp100: a novel bi-specific biologic for the treatment of malignant melanoma Namir J. Hassan, G. Bossi, K. Adams, J. Harper, D. Baker, N. Steven, J. Evans, M. Middleton, Y. McGrath, B. Jakobsen; Abingdon, United Kingdom 151 Posters - August 24 647 P6.06.074 - RNActive - A novel mRNA-based vaccination technology induces strong T- and B-cell responses in phase I/IIa trials in non-small-cell lung cancer and prostate carcinoma patients Regina Heidenreich, M. Sebastian, B. Scheel, S.D. Koch, H. Kübler, A. Stenzl, A. Zippelius, W. Schultze-Seemann, A. Knuth, K. Kallen; Tübingen, Germany 648 P6.06.075 - Limitation of systemic exposure to transgenic interleukin-12 upon local treatment with armed oncolytic adenoviruses M. Bunuales, J. Quetglas, E. Garcia-Aragoncillo, R. Casado, S. Bortolanza, J. Prieto, Ruben Hernandez-Alcoceba; Pamplona, Spain 649 P6.06.076 - Isolation of T cell receptors specific for validated cancer epitopes for cancer immunotherapy Linda Hibbert, L.U. Wiegand, S. Paston, D.E. Baker, J.D. Dukes, J.V. Harper, G. Bossi, F.H. Grand, T.M. Mahon, B.K. Jakobsen; Abingdon, United Kingdom 650 P6.06.077 - Dichloromethane fractions of Scrophularia oxysepala induce apoptosis in MCF-7 human breast cancer cells Behnaz Sadat Hosseini, B. Baradaran, J. Majidiz Zolbanin, A. Pasdaran, T. Kazemi, M. Orangi, L. Mohamadnejad; Tabriz, Iran, Islamic Republic of 651 P6.06.078 - Targeted multivalent scTRAIL fusion proteins for tumor therapy Meike Hutt, M. Siegemund, O. Seifert, K. Pfizenmaier, R.E. Kontermann; Stuttgart, Germany 652 P6.06.079 - Long-term CTL induction and therapeutic tumor suppression by antigen- and adjuvant-carrying polymer nanoparticles Petr Ilyinskii, C. Roy, C. O’Neil, D. Altreuter, K. Kishimoto; Watertown, United States 653 P6.06.080 - Antitumor activity of Her2 liposomes M. Yazdani, A. Badiee, S. Jalali, Mahmoud R. Jaafari; Mashhad, Iran, Islamic Republic of 654 P6.06.081 - Antitumor activity of HER2-MPL Liposomes S. Shariat, S. Mortazavi, A. Badiee, S. Jalali, Mahmoud R. Jaafari; Mashhad, Iran, Islamic Republic of 655 P6.06.082 - Antitumor activity of Her2/CpG liposomes M. Mansourian, A. Badiee, S. Jalali, Mahmoud R. Jaafari; Mashhad, Iran, Islamic Republic of 656 P6.06.083 - Apoptosis induction in head and neck squamous cell line with combined drug therapy N. Cruz de Victo, D. Pinto Junior, G. Amarante-Mendes, Jacqueline Jacysyn; São Paulo, Brazil 657 P6.06.084 - Murine CTL response using rHER2/neu-petide S. Jalali, H. Ghaffari –Nazari, S. Tahaghoghi-ghorbani, Arash Jafari, M.R. Jaafari; Mashhad, Iran, Islamic Republic of 658 P6.06.085 - Synergistic effect of combined local irradiation and dendritic cell vaccine in murine fibrosarcoma tumor Arezoo Jamali, A. Amari, A. Pourgholaminejad, A. Saei, R. Boghozian, Z. Gheflati, N. Sepanlou, J. Hadjati; Tehran, Iran, Islamic Republic of 659 P6.06.086 - Molecular diagnosis of human papilloma virus (HPV) infection in Tunisian women with various types of cervical lesions Mouna Jendoubi; Tunis, Tunisia 660 P6.06.088 - Immunostimulatory properties and antitumor activity of short double-stranded RNA against hepatocarcinoma G29 and melanoma B16 Tatyana O. Kabilova, L.V. Kovtonyuk, E.I. Ryabchikova, E.V. Zonov, N.A. Popova, V.P. Nikolin, M.A. Zenkova, V.V. Vlassov, E.L. Chernolovskaya; Novosibirsk, Russian Federation 661 P6.06.089 - EXOLIGOS: a CpG oligonucleotide loaded exosome nanovesicle delivery platform suitable for effective immune modulation Tamer Kahraman, G. Gucluler, D. Bayik, A. Gursel, I. Gursel; Ankara, Turkey 662 P6.06.090 - In vitro treatment of colon cancer cells with non-toxic concentration of 5-fluorouracil enhances the effectiveness of tumor RNA-transfected DC vaccine C.A. Araujo, J.C.L. Frederico, G.G. Romagnoli, M.B. Magalhães, J.P. Araujo Jr., Ramon Kaneno; Botucatu, Brazil 663 P6.06.092 - Harnessing the IgA Fc RI receptor for antibody therapy William Kelton, N. Mehta, T. Kang, J. Lee, T. Kojima, O. Lungu, M. Donkor, G. Georgiou; Austin, United States 664 P6.06.093 - A new method for in vitro expansion of cytotoxic Natural Killer cells in gastro intestinal cancer Ali Khodadadi, A. Asadirad, A. Talaiezadeh, A. Ghadiri, H. Galehdari, S. Mohaghegh hazrati, M. Oraki, G. Dinarvand, Y. Heike, A. Sheikhi; Ahvaz, Iran, Islamic Republic of 665 P6.06.094 - KLF6-SV1 is overexpressed in T-cells from patients with chronic lymphocytic leukemia Parviz Kokhaei, E. Mikaelsson, F. Mozaffari, A. Mosfegh, M. Hojat Farsangi, F. Pak, A. Österborg, H. Mellstedt; Stockholm, Sweden 152 Posters - August 24 666 P6.06.095 - ImMucin, anti-MUC1 therapeutic Vaccine: Interim analysis from a phase I/II study in myeloma patients Riva Kovjazin, O. Moran, I. Avivi, M.Y. Shapira, L. Carmon; Nes-Ziona, Israel 667 P6.06.096 - Enhanced tumor antigen specific T cells in prostate cancer patients received in situ gene therapy of repeated HSV-tk injection and ganciclovir administration Makoto Kubo, T. Satoh, K. Tabata, K. Matsumoto, N. Yanagisawa, M. Saegusa, I. Okayasu, M. Iwamura, S. Baba, F. Obata; Sagamihara, Japan 668 P6.06.097 - Development of the approach based on dendritic cells transfected with polyepitope DNA-construction for stimulation of antitumor cytotoxic response in colorectal cancer Ekaterina Kulikova, V. Kurilin, I. Obleuhova, Y. Shevchenko, V. Yakushenko, A. Sokolov, S. Sennikov; Novosibirsk, Russian Federation 669 P6.06.098 - Receiving mature dendritic cells in vitro in patients with tumors of different localization Vasily V. Kurilin, I.A. Obleuchova, E.V. Kulikova, J.N. Khantakova, J.A. Shevchenko, V.K. Yakuchenko, A.V. Sokolov, S.V. Sennikov; Novosibirsk, Russian Federation 670 P6.06.099 - Recombinant lipidated HPV E7 induces a Th-1-biased immune response and protective immunity against cervical cancer in a mouse model C. Huang, J.J. Chen, K. Shen, L. Chang, Y. Yeh, Y. Chen, P. Chong, S. Liu, Chih-Hsiang Leng; Zhunan Town, Miaoli,, Taiwan 671 P6.06.100 - In-vivo testing of PSMA-targeted T-cell immunotherapy for prostate cancer Zhe Liu, S. Papa, J. Morris, J. Maher; London, United Kingdom 672 P6.06.101 - Effects on apoptosis and cell cycle arrest contribute to the antitumor responses of interleukin-27 Lihua Liu, S. Baoen; Shijiazhuang, China 673 P6.06.102 - Anti-tumor effect of folate-conjugated chitosan nanoparticles containing the IP-10 gene in mice with hepatocellular carcinoma X. Yu, Y. Xie, C. Lai, J. He, Y. Peng, S. Zhou, X. Xie, G. Luo, N. Zhou, Y. Zhao, Xiaoling Lu; Nanning, China 674 P6.06.103 - Rapid and massive localization of multiple lymphocyte subsets to specific tissues following administration of Interleukin-15 Enrico Lugli, H. Welles, K. Song, B.R. Bryant, C.K. Goldman, S. Rao, K.C. Conlon, T.A. Waldmann, M. Roederer; Rozzano, Italy 675 P6.06.104 - Enhancing the effector functions of tumor-infiltrating lymphocytes with a combination of new genetic adjuvants Alon Margalit, A. Pato, H. Weinstein-Marom, N. Levin, T. Peretz, A. Machlenkin, M. Lotem, G. Gross; Kiryat Shmona, Israel 676 P6.06.105 - Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses Vanesa G. Martinez, R. Fenutría, I. Simões, V. Gil, J. Sintes, C. Raman, P. Engel, M. Ramos-Casals, G. Soldevila, F. Lozano; Barcelona, Spain 677 P6.06.106 - T cell costimulation in cancer immunotherapy with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes Ivan Martinez-Forero, A. Arantza, B. Elixabeth, E. Nistal-Villan, A. Palazon, A. Teijeira, A. Morales-Kastresana, G. Perez-Chacon, J. Zapata, I. Melero; Pamplona, Spain 678 P6.06.107 - Chemokine-receptor modified Adoptive T cell Therapy (ACT) S. Garetto, A. Trovato, Elisa Martini, R. Angioni, C. Soldani, M. Kallikourdis; Rozzano, Italy 679 P6.06.108 - Competent dendrite cell maturation by cocktails containing TLR7/8 agonist for cancer immunotherapy Farimah Masoumi, M. Nourizadeh, A. Memarian, R. Mirzaei, J. Hadjati; Tehran, Iran, Islamic Republic of 680 P6.06.109 - Therapeutic effect of anti- pan HLA-class II mAb 4713 on human lymphoma cells, including Hodgkin lymphoma and Adult T cell leukemia cell lines Shuji Matsuoka, Y. Ishii, A. Nakao, H. Yagita, M. Abe, N. Mizutani, O. Naomi, K. Terashima, O. Hino; Tokyo, Japan 681 P6.06.110 - Identification of unique colorectal cancer T-cell antigens by next generation sequencing of somatically mutated genes Daniele Mennonna, C. Maccalli, M. Romano, R. Bordoni, G. De Bellis, E. Orsenigo, L. Albarello, G. Casorati, G. Parmiani, P. Dellabona; Milan, Italy 682 P6.06.111 - Examination of an immunoregulator in a syngeneic animal model Giovanna Merchand-Reyes, M.A. Becerril-García, I. Gracia-Mora, S. Estrada-Parra, I. Estrada-Garcia, S.M. Perez-Tapia, C. SandovalMontes; Mexico City, Mexico 683 P6.06.112 - Evaluation of anti-proliferative activity of ruthenium (III) compounds on human cancer cell lines using RTCA - xCELLigence System Mirela A. Mihaila, M. Bostan, G.G. Matei, V. Uivarosi, L.I. Brasoveanu; Bucharest, Romania 684 P6.06.113 - Competent maturation of human dendritic cells by protein fractions of listeria monocytogenes Reza Mirzaei, A. Saei, R. Boghozian, B. Vaziri, J. Hadjati; Tehran, Iran, Islamic Republic of 153 Posters - August 24 685 P6.06.114 - Cloning and expression of human L- Asparaginase and study of its anti growth effect on leukemia cell lines Leila Mohammadnejad, B. Baradaran, D. Shanehbandi, M. Pourhassan Moghaddam, S. Sadreddini; Tabriz, Iran, Islamic Republic of 686 P6.06.115 - Exosomes displaying high expression of CD24 and HSP90 induced cellular and humoral immune response “in vivo” Claudia Mongini, J. De Toro, P. Di Sciullo, F. Menay, M. Gravisaco, A. Vendrell, C. Waldner, L. Hershlik; Buenos Aires, Argentina 687 P6.06.116 - Imiquimod enhances anti-lymphoma response in a tumor cell lysate vaccine and inhibits tumor cells growth Claudia Mongini, J. De Toro, L. Hershlik, M. Gravisaco, C. Waldner, P. Di Sciullo; Buenos Aires, Argentina 688 P6.06.117 - Therapeutic activity of a combination of immunostimulatory monoclonal antibodies (anti-B7-H1, CD137 and OX40) on a c-myc-driven spontaneous transgenic model of hepatocellular carcinoma Aizea Morales-Kastresana, M.F. Sanmamed, I. Rodriguez, A. Palazon, I. Martinez-Forero, S. Labiano, S. Hervas-Stubbs, B. Sangro, C. Ochoa, A. Azpilikueta; Pamplona/Iruña, Spain 689 P6.06.118 - Establishment of human cancer stem-like cell targeting immunotherapy Rena Morita, Y. Hirohashi, T. Torigoe, A. Takahashi, T. Terui, Y. Tamura, S. Hashino, A. Taketomi, S. Todo, N. Sato; Sapporo, Japan 690 P6.06.119 - Schedule-dependent anticancer therapy by targeting TNF-alpha to tumor vessels in combination with melphalan and gemcitabine Lorenzo Mortara, P. Orecchia, P. Castellani, L. Borsi, B. Carnemolla, E. Balza; Varese, Italy 691 P6.06.120 - High-level expression of IGFBP-3 by recombinant vaccinia virus leads to its incorporation into IMV and affects virus replication and immunogenicity Jan Musil, L. Kutinova, K. Zurkova, P. Hainz, K. Babiarova, J. Krystofova; Prague, Czech Republic 692 P6.06.121 - Syntesis of matrix and matrix metalloproteases in 2D and 3D cultures of pancreatic cells Ekaterina V. Myrsikova, E.N. Kaliberda, E.V. Svirshchevskaya; Moscow, Russian Federation 693 P6.06.122 - Selective killing of activated B-cells and inhibition of antibody production with bispecific CD20 x CD95 antibodies Kristina Nalivaiko, M. Hofmann, L. Grosse-Hovest, P.H. Krammer, H. Rammensee, G. Jung; Tübingen, Germany 694 P6.06.123 - Modulating effects of different doses of 5-flurouracil (5-FU) on the maturation and function of dendritic cells (DC) in vitro Afshin Namdar, M. Hafezi, N. Khosravianfar, A. Rezaei, J. Hadjati; Isfahan, Iran, Islamic Republic of 695 P6.06.124 - Outer membrane proteins and vesicle proteins targeted as new vaccine strategies for pathogenic gram negative bacteria through particulate delivery system Bismita Nayak, P.R. Rauta; Rourkela, India 696 P6.06.125 - Down-regulation of pro-angiogenic and pro-metastatic genes in scFvs treated breast cancer cells Foroogh Nejatollahi, V. Younesi, M. Asgharpour; Shiraz, Iran, Islamic Republic of 697 P6.06.126 - Down-regulation of Epidermal Growth Factor in a breast cancer cell line treated with anti-HER2 single chain antibodies Foroogh Nejatollahi, M. Asgharpour, V. Younesi; Shiraz, Iran, Islamic Republic of 698 P6.06.127 - IL-12 immunotherapy: characterization of a CD4+ effector population Megan E. Nelles, C.L. Furlonger, J.A. Medin, C.J. Paige; Toronto, Canada 699 P6.06.128 - EBV-transformed Lymphoblastoid Cell Lines as Vaccines against Cancer Testis Antigen-positive Tumors Frank Neumann, D. Kaddu-Mulindwa, T. Widmann, K.D. Preuss, G. Held, C. Zwick, K. Roemer, M. Pfreundschuh, B. Kubuschok; Homburg, Germany 700 P6.06.129 - ENO1-specific Tregs frustrate Th1/Th17 effector cells isolated from pancreatic cancer patients Elena Niccolai, P. Cappello, C. della Bella, M. Benagiano, F. Cianchi, L. Bencini, F. Novelli, M. D’Elios, A. Amedei; Florence, Italy 701 P6.06.130 - IgE as a new player in tumor surveillance Elisa Agnese Nigro, V. Yenagi, E. Soprana, A.T. Brini, A.G. Siccardi, L. Vangelista; Milan, Italy 702 P6.06.131 - First exploration of clinical value of telomerase expression in triple-negative breast cancer tissues Malyshev Nikolay, E. Gross, R. Napieralski, H. Jansen, F. Yang, M. Kiechle, M. Aubele, M. Schmitt; Munich, Germany 703 P6.06.132 - Tumor-associated antigen-specific CD4+ T-cell immunity augmented by CTL-epitopes vaccination in patients with malignant tumor Y. Tomita, A. Yuno, H. Tsukamoto, Y. Yoshitake, T. Tsunoda, Y. Nakamura, M. Shinohara, Yasuharu Nishimura; Kumamoto, Japan 154 Posters - August 24 704 P6.06.133 - Effect of mature dendritic cells primed with autologous tumor antigens, patients with epithelial ovarian cancer to stimulate the cytotoxic activity of mononuclear cells in vitro Irina Obleuhova, V. Kurilin, M. Goncharov, A. Tarkhov, S. Krasilnikov, S. Sennikov; Novosibirsk, Russian Federation 705 P6.06.134 - Immunotherapeutic and toxic effects of a triple fusion protein encompassing apolipoprotein A-I, interleukin-15 and the interleukin-15 receptor sushi domain Maria C. Ochoa, J. Fioravanti, R. Inmaculada, S. Hervas-Stubbs, A. Azpilicueta, G. Mazzolini, A. Gurpide, J. Prieto, P. Berraondo, I. Melero; Pamplona, Spain 706 P6.06.135 - Cytotoxic effect of methanolic fractions of Scrophularia oxysepala on MCF-7 human breast cancer cell line Mona Orangi, B. Baradaran, T. Kazemi, A. Pasdaran, J. Majidi Zolbanin, B. Hosseini, L. Mohammadnejad; Tabriz, Iran, Islamic Republic of 707 P6.06.136 - Discovery of chemotherapy induced ovarian cancer antigens by interrogating memory T cells Fabio Palombo, M. Paroli, F. Bellati, M. Videtta, T. Donato, C. Mancone, D. Accapezzato, S. Piconese, P. Benedetti Panici, V. Barnaba; Rome, Italy 708 P6.06.137 - G1-4A, a polysaccharide from T. Cordifolia induces killer phenotype and increases dendritic cell immunogenicity in murine lymphoma model Vipul K. Pandey, B. Shankar, K.B. Sainis; Mumbai, India 709 P6.06.138 - Bivalent CD28 agonistic aptamer: a novel adjuvant-vaccine for lymphoma Fernando Pastor, M.M. Soldevilla, H. Villanueva, S. Inoges, A.L. de Cerio, M. Bendandi; Pamplona, Spain 710 P6.06.139 - Abrogation of tumor-associated immunosuppression by targeting tumor-infiltrating regulatory T-cell function can restore impaired T cell responses in patients with liver cancer Alexander Pedroza Gonzalez, J. Kwekkeboom, S.P. Singh, E. Tjwa, W.G. Polak, D.J. Grünhagen, K. Biermann, J.N.M. Ijzermans, H.L.A. Janssen, D. Sprengers; Rotterdam, Netherlands 711 P6.06.140 - Cancer from hell: Devil Facial Tumour Disease Terry Pinfold, G. Brown, A. Kreiss, G. Woods; Hobart, Australia 712 P6.06.141 - Expression patterns of cancer/testis antigens constitute a stable patient-specific fingerprint in multiple recurrent lesions of evolving metastatic melanoma Zoltan Pos, J.R. Wunderlich, D.F. Stroncek, J.A. Malek, P.F. Robbins, L. Rivoltini, M. Maio, L. Chouchane, E. Wang, F.M. Marincola; Budapest, Hungary 713 P6.06.142 - Targeting Th17-associated cytokines with a bi-specific antibody improves anti-myeloma responses Rao H. Prabhala, M. Fulciniti, J. Bae, A. Nigroiu, S. Lee, J.F. Daley, M. Marelli, K. Grabstein, K.C. Anderson, N.C. Munshi; Boston, United States 714 P6.06.143 - Anti-tumor activities of human Vγ9Vδ2 T cells in combination with zoledronic acid in a pre-clinical model of neuroblastoma E. Di Carlo, P. Bocca, L. Emionite, M. Cilli, G. Cipollone, F. Morandi, L. Raffaghello, V. Pistoia, Ignazia Prigione; Genoa, Italy 715 P6.06.144 - Analysis of IL-10 serum levels in epithelial ovarian carcinoma in comparison to Ovarian benign Cyst S. Rezaeifard, Shahrzad Rahimifar, M. Razmkhah; Shiraz, Iran, Islamic Republic of 716 P6.06.145 - Equipotent antagonism towards both ligands and excellent anti-tumor efficacy with a peptide inhibitor of PD-1 immune check point pathway P.G. Sasikumar, R.K. Shrimali, L.K. Satyam, S. Adurthi, R. Ramachandra, S. Vadlamani, K.A. Reddy, D.S. Samiulla, K. Sunilkumar, Murali Ramachandra; Bangalore, India 717 P6.06.146 - Development of a monoclonal antibody against the canine CCR2 as a new targeted anticancer therapy in the scope of comparative oncology Teresa P. Raposo, D.J. Argyle, B.C.B. Beirao, I. Pires, F.L. Queiroga; Vila Real, Portugal 718 P6.06.147 - Anti EGFR monoclonal antibody inhibits prostate cancer PC3 cells growth Alireza Rezaiemanesh, J. Majidi, B. Baradaran, A. Movasaghpour, A. Nakhlband, J. Barar, Y. Omidi; Tehran, Iran, Islamic Republic of 719 P6.06.148 - Characterization of a genetic mouse model of lung cancer: a promise to identify oncoantigens associated with different stages of NSCLC progression Federica Riccardo, M. Arigoni, M. Iezzi, D.L. Longo, M. Carrara, A. Fiore, G. Forni, R.A. Calogero, E. Quaglino, F. Cavallo; Torino, Italy 720 P6.06.149 - Tumour vaccine for oral cancer: prospects and challenges Gabriel Rodrigues; Manipal, India 721 P6.06.150 - Multifaceted immunotherapeutic effects of vitamin D-binding protein-derived macrophage activating factor (GcMAF) on human breast cancer and neuroblastoma cells Marco Ruggiero, S. Pacini, G. Morucci, J.J.V. Branca, E. Ward, R.J. Smith, L. Thyer, M. Gulisano; Firenze, Italy 722 P6.06.151 - In vitro cytotoxic effects of dichloromethane extract of Scrophularia atropatana on WEHI-164 cells Elham Safarzadeh, B. Baradaran, A. Delazar, T. Kazemi, M. Orangi, D. Shanehbandi, S. Esnaashari; Tabriz, Iran, Islamic Republic of 155 Posters - August 24 723 P6.06.152 - Tumour cell lysate loaded-Dendritic Cell vaccine induces biochemical and memory immune response in castration-resistant prostate cancer patients D. Reyes, C. Pereda, E. Castellón, R. Valdenevito, M. López, Flavio Salazar-Onfray; Santiago, Chile 724 P6.06.153 - Evaluation of anti-FoxP3 vaccine efficacy following DNA-protein prime-boost immunization in mice Morteza Samadi, A. Memarnejadian, R. Vahabpour, S. Sadat, M. Aghasadeghi, J. Hadjati; Yazd, Iran, Islamic Republic of 725 P6.06.154 - The relevance of heat shock protein 90 and its role in cancer treatment Alessandra Santos, B. Campostrini, M. Geller, A. Abrahão, L. Oliveira, K. Cunha, A. Fonseca, M. Ribeiro, M. Romero, E. Naliato; Rio de Janeiro, Brazil 726 P6.06.155 - Pseudo-exhaustion of CD8+ T cells in acute myeloid leukemia (AML) Frauke M. Schnorfeil, K. Emmerig, J. Neitz, F.S. Lichtenegger, R. Draenert, W. Hiddemann, M. Subklewe; Munich, Germany 727 P6.06.156 - Functionalized polyethyleneimine-based nanoparticles improve antigen cross-presentation of murine bone marrow derived macrophages and dendritic cells depending on size and zeta potential Matthias Schröder, A. Schallon, M. Wagner, M. Gottschaldt, U. Schubert, P. Knolle; Bonn, Germany 728 P6.06.157 - Immunopharmacodynamic response to blinatumomab in patients with relapsed/refractory B-precursor acute lymphoblastic leukaemia (ALL) Andrea Schub, V. Nägele, G. Zugmaier, C. Brandl, Y. Hijazi, M.S. Topp, P. Kufer, A. Wolf, M. Klinger; Munich, Germany 729 P6.06.158 - Role of the transcription factor forkhead box P3 in breast cancer and metastasis Lucia Sfondrini, A. Cataldo, V. Uva, T. Triulzi, P. Casalini, E. Tagliabue, A. Balsari; Milan, Italy 730 P6.06.159 - Production of lacZ inducible T cell hybridoma specific for human and mouse gp10025-33 peptides Adi Sharbi-Yunger; Rehovot, Israel 731 P6.06.160 - Dendritic cells transfected with allel-specific polyepitope DNA-constructs stimulate cytotoxic response mononuclear cells of breast cancer patients in vitro Yulia A. Shevchenko, S. Sennikov, Y.N. Khantakova, V.V. Kurilin, Y.A. Lopatnikova, S.V. Sidorov, A.Z. Maksyutov, R.A. Maksyutov, E.V. Gavrilova, S.A. Zaytsev; Novosibirsk, Russian Federation 732 P6.06.161 - Supportive involvement of tumor-associated myeloid cells in RNA adjuvant therapy for cancer Hiroaki Shime, M. Matsumoto, T. Seya; Sapporo, Japan 733 P6.06.162 - The cross-talk between plasmacytoid DC and conventional DCs shapes the anti-tumor memory CD8+T cells Kanako Shimizu, S. Fujii; Yokohama, Japan 734 P6.06.163 - Immunization against tumor-associated macrophages - enhancement of DNA vaccine potency against legumain Michal Smahel, M. Duskova, I. Polakova, J. Musil, M. Petrackova; Prague, Czech Republic 735 P6.06.164 - New role for Toll-like receptor 9 agonists, CpG-ODN as cancer cell “chemosensitizer” Michele Sommariva, L. Sfondrini, L. De Cecco, E. Wang, E. Tagliabue, A. Balsari; Milan, Italy 736 P6.06.166 - Dual targeting by TCR-redirected T cells enables remission from autochthonous mouse prostate cancer and long-term disease-free survival T. Manzo, Tabea Sturmheit, V. Basso, R. Hess Michelini, I. Olvera Gomez, T. Schumacher, M. Bellone, A. Mondino; Milan, Italy 737 P6.06.167 - Targeting the self-antigen nucleolin for antibody immunotherapy of breast and other cancers Natalie Sutkowski, W. Sun, D. Fernandes, S. Rubinchik; Charleston, United States 738 P6.06.168 - Low dose radiation-mediated enhanced effector function regulated by the ERK1/2 pathway in human T cells Zsuzsanna Tabi, L.K. Spary, S. Al-Taei, J. Salimu, A. Clayton, J. Staffurth, M.D. Mason; Cardiff, United Kingdom 739 P6.06.169 - Enhancement of antigen-specific CTL inducing ability in the leukemic plasmacytoid dendritic cell line (PMDC11) by lentiviral vector-mediated transduction of caTLR4 gene Masuhiro Takahashi, M. Iwafuchi, A. Yamahira, N. Satoh, T. Uchiyama, S. Hashimoto, A. Bonehill, E. Faure-Kumar, N. Kasahara, M. Narita; Niigata, Japan 740 P6.06.170 - TAPCells based vaccination induce specific anti NY-ESO1 immune response in melanoma patients F. Tempio, P. Guerrero, F. Falcon-Beas, I. Flores, C. Falcon-Beas, J. Gatica, F. Salazar-Onfray, Mercedes N. Lopez; Santiago, Chile 741 P6.06.171 - HSV-1 activated plasmacytoid dendritic cells inhibit melanoma cell growth Sabrina Thomann, J.B. Boscheinen, B. Schuler-Thurner, S. Groß, B. Schmidt; Erlangen, Germany 742 P6.06.172 - Polysaccharide nanocomplexes harboring split vaccine and TLR ligands are potent vaccine carriers against influenza Gizem Tincer, C. Coban, K. Ishii, I. Gursel; Ankara, Turkey 156 Posters - August 24 743 P6.06.173 - Protein chimera of IL-2-S4B6 mAb exerts similar or even higher biological activity as IL-2/S4B6 mAb immunocomplexes in vivo Jakub Tomala, J. Kovarova, M. Kabesova, P. Votavova, H. Chmelova, B. Dvorakova, B. Rihova, M. Kovar; Prague, Czech Republic 744 P6.06.174 - Search for an association between JC virus (JCV) and colorectal cancer in Tunisian patients Wafa Toumi, A. Ripalti, L. Ricciardiello, A. Cherif, J. Kharrat, M. Jendoubi, F. Ghoul, L. Satouri, M. Zili, R. Khelifa; Tunis, Tunisia 745 P6.06.175 - Chemotherapy can enhance trastuzumab-mediated ADCC Tiziana Triulzi, L. Sfondrini, S. Varchetta, V. Regondi, M. Sasso, P. Casalini, G. Bianchi, G. Mariani, A. Balsari, E. Tagliabue; Milan, Italy 746 P6.06.176 - Osteosarcoma antigen PBF-derived peptides could elicit immunological response in patients with refractory osteosarcoma Tomohide Tsukahara, M. Emori, A. Takahashi, T. Torigoe, T. Yamashita, N. Sato, T. Wada; Sapporo, Japan 747 P6.06.177 - Tattoo delivery of Semliki Forest virus-based immunization strategies against cervical cancer Stephanie van de Wall, T. Daemen; Groningen, Netherlands 748 P6.06.178 - A new identified CD20-spliced protein as potential target for T cell-based immunotherapy in B-cell lymphoma/leukemia patients Charline Vauchy, C. Gamonet, E. Daguindau, C. Henry, P. Rohrlich, O. Adotevi, C. Borg, C. Ferrand, Y. Godet; Besançon, France 749 P6.06.179 - Immunotherapy for the liver metastases prevention with a vaccine strain of an attenuated Salmonella Typhi Alejandrina Vendrell, A. Tesone, J. De Toro, L. Herschlik, M. Gravisaco, J. Goin, G. Larotonda, C. Mongini, C. Waldner; Buenos Aires, Argentina 750 P6.06.180 - Antitumor activity of a Salmonella Typhi vaccine strain in a mouse model of T-cell lymphoma Alejandrina Vendrell, A. Tesone, J. De Toro, L. Herschlik, M.J. Gravisaco, J.C. Goin, G. Larotonda, C. Mongini, C.I. Waldner; Buenos Aires, Argentina 751 P6.06.181 - Lcn2 secreted from DCs induces CD8+ T-cell apoptosis, it is involved in T-cell priming, and upon DCs vaccination trigger a Th1 phenotype M. Floderer, M. Prchal, J. Warszawska, S. Knapp, T. Felzmann, Caterina Vizzardelli; Vienna, Austria 752 P6.06.182 - Allogeneic dendritic cells induce potent antitumor immunity by activating KLRG1+CD8 T cells Chao Wang, Z. Zhu, Y. Wu, X. Liu, Y. Wang, Z. Li, D. Peng, Z. Chang, X. Cao, M. Zhang; Beijing, China 753 P6.06.183 - Expression of cancer testis antigens (CTAs) and its correlation with clinical parameters in Chinese hepatocellular carcinoma Meng Wang, J. Li, Y. Zhao, D. Li, Z. Fan, Y. Sun, Z. Tang, Z. Li, S. Wu, Y. Zhang; Zhengzhou, China 754 P6.06.184 - Cell surface delivery of TRAIL strongly augments the tumoricidal activity of T-cells Valerie R. Wiersma, M. de Bruyn, D.F. Samplonius, W. Helfrich, E. Bremer; Groningen, Netherlands 755 P6.06.185 - NK depletion enhances the rejection of established melanoma by tumor-specific CD4+ T cells Kyle A. Wilson, S.R. Goding, K.M. Harris, H.R. Neeley, P.A. Antony; Baltimore, United States 756 P6.06.186 - IL-17A promotes immune cell recruitment in human esophageal cancers Jian-chuan Xia, L. Lv, K. Pan; Guangzhou, China 757 P6.06.187 - The effects of esomeprazole combined with classical cancer drugs on lung cancer cells and peripheral blood mononuclear cells Arzu Yılmaztepe Oral, &. Korkmaz, F. Budak, G. Özkaya, E. Ulukaya, H. Oral; Bursa, Turkey 758 P6.06.188 - Establishment of a lymphoblastoid cell line with B1 cell characteristics derived from a chronic lymphocytic leukemia patient by in vitro EBV transformation Vahid Younesi, H. Nikzamir, M. Hojjat-Farsangi, S. Razavi, F. Shokri; Shiraz, Iran, Islamic Republic of 759 P6.06.189 - Identification of surface molecules with enzymatic and signaling proprieties as targets for mAb-immunotherapy of human prostate cancers Gianluca Zaccarello, A. Zitella, V. Quarona, L. Daniele, G. Chiorino, M. Bellò, A. Tizzani, A.L. Horenstein, G. Bisi, F. Malavasi; Torino, Italy 760 P6.06.190 - Modulation of tumor microenvironment associated with tumor regression in melanoma patients receiving adoptive cell transfer therapy Juhua Zhou, B. Xiao, J. Sun, Z. Liu, Y. Zhong, G. Zhang, X. Chi, Q. Huang; Yantai, China 761 P6.06.191 - A tumor vaccine against chronic lymphocytic leukemia Fang Zhu, R. Gorczynski, D.E. Spaner; Toronto, Canada 157 Posters - August 24 762 P6.06.192 - Construction and functional activity of shRNA targeting Wnt-1 gene hyperexpressed by Wnt-1 breast tumors in mice Dmitrii A. Zubkov, A.A. Lysenko, E.V. Smirnova, A.A. Zubareva, E.V. Svirshchevskaya; Moscow, Russian Federation P6.16 BIOMARKERS AND CLINICAL PROFILING OF HUMAN IMMUNE RESPONSES Session Time: Saturday, August 24, 13:20 - 15:00 763 P6.16.01 - Slceroderma: from clinical classification to autoantibodies profile R. Assandri M. A. Montanelli; Rozzano, Italy 764 P6.16.02 - Biomarkers associated with treatment failure in Kawasaki disease Jun Abe, S. Fukuda, H. Masuda, N. Sakamoto, S. Oana, H. Kato; Tokyo, Japan 765 P6.16.03 - Is Basophil Activation Test as a Safe Diagnostic Tool for Immediate Drug Hypersensitivity to Proton-Pump Inhibitors? Nilgun Akdeniz, L. Pur Ozyigit, B. Ertek, B. Aydin, D. Unal, M. Demirturk, A. Gelincik, S. Buyukozturk, B. Colakoglu, G. Deniz; Istambul, Turkey 766 P6.16.04 - HLA-G 14-bp Deletion/Insertion, 3003C/T, 3010C/G and 3027A/C polymorphisms in HTLV-1 infection Daiani C.C. Alves, M. Rocha-Júnior, R. Haddad, W. Virginia, O. Takayanagui, D. Covas, S. Kashima, E.A. Donadi; Ribeirão Preto, Brazil 767 P6.16.05 - Different In vitro profiles of biologicals in human PBMC lymphocytes activation assay Filippo Andreetta, E. Vicentini, F. Zanderigo, E. Zambello, J. Chappell; Verona, Italy 768 P6.16.06 - Standardization of ELISPOT counts for accurate assessment of human T cell responses performed by 10 different laboratories Tameem Ansari, A.Y. Karulin, P.V. Lehmann, S. Sundararaman; Shaker Heights, United States 769 P6.16.07 - A novel mechanism for recognition of a small molecule carbohydarte immunotherapeutic by human myeloid cells: Potential for modulation of efficacy in the clinic Mary A. Antonysamy, M.I. Nelson, R. Walsh, N.R. Ottoson, B. Rathmann, W. Grossman; Eagan, United States 770 P6.16.08 - Surface Plasmon Resonance Imagery-based strategy to study hnRNPA2/B1 peptides as specific biomarkers in systemic lupus erythematosus, rheumatoid arthritis and autoimmune hepatitis E. Beleoken, H. Leh, Eleonora De Martin, C. Johanet, D. Samuel, J. Duclos-Vallée, M. Buckle, E. Ballot; Villejuif, France 771 P6.16.09 - A novel cell-based assay for measuring neutralizing autoantibodies against type I interferons in patients with autoimmune polyendocrine syndrome type 1 Lars Breivik, E. Bratland, A. Hellesen, B. Oftedal, A.S. Bøe Wolff, E.S. Husebye; Bergen, Norway 772 P6.16.10 - Increased circulating levels of leukocytes, lymphocytes and atypical lymphocytes in patients with dengue hemorrhagic fever A.I.V. Fernandes, F.J. Rolim, L.H. Simões, Lucio R. Castellano; João Pessoa Paraíba, Brazil 773 P6.16.11 - Cancer Testis Antigens Expression: Sex and Multiple Myeloma Maurizio Chiriva-Internati, L. Mirandola, Y. Yu, M. Jenkins, J.A. Figueroa, E. Cobos; Lubbock, United States 774 P6.16.12 - Cancer treatment and diagnosis using cancer testis antigens for multiple myeloma Maurizio Chiriva-Internati, L. Mirandola, Y. Yu, F. Hardwicke, N. D’Cunha, L. Tijani, D.D. Nguyen, J.A. Figueroa, E. Cobos; Lubbock, United States 775 P6.16.13 - The cancer/testis antigens, SP17, AKAP4, and PTTG1 are expressed in non-small cell lung cancer: new biomarkers and vaccine targets Maurizio Chiriva-Internati, L. Mirandola, Y. Yu, C. Jumper, R. Alalawi, J.A. Figueroa, E. Cobos; Lubbock, United States 776 P6.16.14 - Proteomic analysis of aqueous humor from uveitis patients Pitipol Choopong, N. Tesavibul, V. Thongboonkerd; Bangkok, Thailand 777 P6.16.15 - Intracellular modulation, extracellular disposal and serum circulating increase of miR-150 upon lymphocyte activation Paola de Candia, A. Torri, T. Gorletta, E. Bulgheroni, M. Fedeli, L. Romanò, S. Esposito, G. Casorati, M. Pagani, S. Abrignani; Milan, Italy 778 P6.16.16 - Identification of biomarkers associated with treatment for latent tuberculosis by microarray Eleane de Oyarzabal, T. Herrera, L. Orozco, C. Rangel-Escareño, L. Ferreyra-Reyes, P. Cruz-Hebert, L. Garcia-Garcia, R.J. Wilkinson, E. Sada, M. Torres; Mexico, Mexico 779 P6.16.17 - Novel monoclonal antibodies against human Carbonic Anhydrase XII, a potential biomarker of tumor cells Dovile Dekaminaviciute, R. Lasickiene, M. Zilnyte, V. Jogaite, V. Michailoviene, S. Parkkila, D. Matulis, A. Zvirbliene; Vilnius, Lithuania 158 Posters - August 24 780 P6.16.18 - Tertiary lymphoid structures have features of an ongoing humoral immunity with a benefit for lung cancer patients Marie-Caroline Dieu-Nosjean, F. Tamzalit, C. Germain, A. Lepelley, R. Remark, A. Lupo, D. Damotte, P. Validire, W. Fridman, C. Sautès-Fridman; Paris, France 781 P6.16.19 - Assessment the immune responses in the microenvironment of breast cancer tissues Rahil Eftekhari, H. Shirzad, R. Esmaeili, K. Majidzadeh, J. Hadjati; Tehran, Iran, Islamic Republic of 782 P6.16.20 - Molecular allergology : Component resolved diagnostics for managing cow’s milk allergy in West Algeria Kamel Eddine El Mecherfi, W. Hachelaf, G. Boudraa, H. Rabesona, Y. Choiset, J. Chobert, O. Kheroua, M. Touhami, T. Haertlé, D. Saidi; Oran, Algeria 783 P6.16.21 - Timing of blood sampling for CD4 T-cell count influences HAART decisions Yonas B. Feyissa; Addis Ababa, Ethiopia 784 P6.16.22 - ACTC1, CCR5, TNF/LTA, CCL2, IL12B, IL10, MAL/TIRAP genes are associated to the development of Chronic Chagas disease cardiomyopathy Amanda F. Frade-Barros, P.C. Teixeira, M. Baron, B. Ianni, A.C. Pereira, C.W. Pissetti, V. Rodrigues, J. Kalil, C. Chevillard, E. Cunha-Neto; Sao Paulo, Brazil 785 P6.16.23 - Serological proteome analysis (SERPA) as a tool for the identification of tumor antigens capable of eliciting immune responses in chronic lymphocytic leukemia (CLL) Valentina Griggio, G. Mandili, C. Vitale, M. Capello, F. Novelli, M. Boccadoro, M. Massaia, M. Coscia; Torino, Italy 786 P6.16.24 - Impact of excipients and pH on the in vitro hemolysis by IgG solutions Andrea Heger, A. Zöchling, G. Kohla, T. Svae, J. Römisch; Vienna, Austria 787 P6.16.25 - Exhausted CD8 T cells in peripheral blood of breast cancer patients Joselin Hernandez-Ruiz, C. Lara-Gutierrez, H. Miranda-Hernandez, E. Gutierrez-Reyes; Mexico, Mexico 788 P6.16.26 - The impact of polymorphisms in the host immune response genes on the severity of chronic hepatitis C Xuan S. Hoang, M. Thelu, E.J. Marche, N. Sturm, V. Leroy, J.P. Zarski, P. Marche; Grenoble, France 789 P6.16.27 - Peptide Microarrays with Near Zero background enable high quality and massive data production from seroscreening of autoimmune diseases Mo Huang, Y. Lu, C. Liu, Z. Li, X. Liu, H. Ma; Suzhou, China 790 P6.16.28 - Chronic myeloid leukemia patients in prolonged remission after interferon monotherapy have constantly active NK-cells Mette M. Ilander, A. Kreutzman, P. Rohon, T. Melo, E. Faber, K. Porkka, J. Vakkila, S. Mustjoki; Helsinki, Finland 791 P6.16.29 - Neutrophil gelatinase-associated lipocalin in chronic heart failure Nilgun Isiksacan, M. Koser, M. Erturk, I. Akturk, S. Yazan, M. Yildirim, V. Ornek Diker, I. Bakir; Istanbul, Turkey 792 P6.16.30 - Post-traumatic Immunosuppression and its Reversal Nahidul Islam, M. Whitehouse, S. Mehandale, M. Hall, A. Blom, G. Bannister, J. Hinde, R. Ceredig, B. Bradley; GALWAY, Ireland 793 P6.16.31 - Monocyte surface antigen expression in severe sepsis Joel Jamsa, V. Huotari, E. Savolainen, H. Syrjala, T. Ala-Kokko; Oulu, Finland 794 P6.16.32 - Change in immune cells population following exposure to the venom from Hemiscorpius lepturus scorpion venom Ali Khodadadi, M. Pipelzadeh, Y. Heike, M. Assarehzadegan, B. Vazirianzadeh; Ahvaz, Iran, Islamic Republic of 795 P6.16.33 - Clinical utility of interferon-γ releases assay (IGRAs) in new and retreated cases of Pott’s disease at a tertiary care hospital Manoj Kumar, R. Kumar, A.K. Srivastava, V.L. Nag, N. Krishnani, A.K. Maurya, T.N. Dhole, S.G. Babu; Lucknow, India 796 P6.16.34 - Collagen Triple Helix Repeat Containing 1 (CTHRC1) Acts via ERK-Dependent Induction of MMP9 to Promote Invasion of Colorectal Cancer Cells J. Kim, Y. Choe, B. Kim, K. Kim, J. Kim, S. Lee, Hee Gu Lee; Daejeon, Korea, Republic of 797 P6.16.35 - High expression of prolactin receptor is associated with cell survival of cervical cancer cells Edgar I. López-Pulido, R. Ascencio-Cedillo, J.F. Muñoz-Valle, S. Del Toro-Arreola, C. Estrada-Chávez, A.L. Pereira-Suárez; Guadalajara, Mexico 798 P6.16.36 - A standardized long-term culture assay to measure antigen-specific memory T cells Franco Lori, G. Cugia, C. Pisano, D. De Forni, T. Bitai, S.A. Calarota, J. Lisziewicz; Alghero, SS, Italy 159 Posters - August 24 799 P6.16.37 - Development of the MeDALL allergy-chip, an allergen micro-array comprising 176 components for sensitive detection of allergen-specific antibodies Christian Lupinek, E. Wollmann, J. Bousquet, J.M. Anto, C. Harwanegg, R. Valenta; Vienna, Austria 800 P6.16.38 - Association between reduction of plasma adiponectin levels and risk of bacterial infection after gastric cancer surgery Kazuhisa Maeda, H. Yamamoto, Y. Uji, H. Tsuchihashi, T. Shimizu, Y. Endo, A. Kadota, K. Miura, T. Ito, T. Tani; Suita, Osaka, Japan 801 P6.16.39 - Mitral valve proteomic analysis: novel insights into rheumatic heart disease mechanisms Carlo O. Martins, K.S. Santos, F.M. Ferreira, E. Cunha-Neto, J. Kalil, L. Guilherme; São Paulo, Brazil 802 P6.16.40 - Transient alteration in cytokine patterns following influenza vaccination detected by Ki-67 expression and automated multiparameter analysis of flow cytometry Tim R. Mosmann, D. Roumanes, I. Naim, A. Rosenberg, J. Weaver, Y. Qi, A.M. Livingstone, G. Sharma; Rochester, United States 803 P6.16.41 - Recurrent ulcerative stomatitis and its correlation with psychological factors Mohammad Naghavi - Behzad, A. Naghavi-Behzad, M. Ghojazadeh, R. Piri, F. Pournaghi Azar; Tabriz, Iran, Islamic Republic of 804 P6.16.43 - Serum hepcidin levels in patients with Brucellosis E. Yılmaz, A. Oguz Ayarcı, D. Sıgırlı, M. Öner Torlar, F. Budak, G. Göral, Haluk B. Oral; Bursa, Turkey 805 P6.16.44 - A unique endotoxin tolerance profile strongly predominates during clinical sepsis Olga M. Pena, D.G. Hancock, J. Xia, C.D. Fjell, R.E.W. Hancock; Vancouver, Canada 806 P6.16.45 - Changes in IgA and IgM in saliva and serum of newborns during the first 30 days of life Sandra Pineda-Martínez, J. Hernández-Islas, B. Tecuatl-Herrada, D. Correa; Mexico City, Mexico 807 P6.16.46 - Lipid profile analysis in spinal trauma patients shows severe distortion of AA/DHA after injury Danuta Radzioch, J.B. De Sanctis, G. Wojewodka, M. Radhakrishna, I. Makriyianni, S. Parent, J. Ouellet, S. David; Montreal, Canada 808 P6.16.47 - Kinetics of inflammatory markers following traumatic injuries to the spinal cord Danuta Radzioch, G. Wojewodka, S. David, I. Makriyianni, M. Radhakrishna, S. Parent, J. Ouellet; Montreal, Canada 809 P6.16.48 - Circulating IL-12 and response to therapy in HCV-infected patients: Potential biomarker for a non-favorable outcome? F.A. Pereira, L.A.O. Pereira, T.M.A. Carmo, R. Paraná, A.T. Carvalho, O.A. Martins-Filho, J. Hagan, E.A.G. Reis, Mitermayer G. Reis; Salvador/Ba- Brazil, Brazil 810 P6.16.49 - Association of IL28B (rs12979860) and IL-12B (rs3212227) polymorphisms with response to HCV-therapy inpatients with a mixed genetic background F.A. Pereira, L.A.O. Silva, T.M.A. Carmo, J. Hagan, R. Paraná, Mitermayer G. Reis; Salvador/Ba- Brazil, Brazil 811 P6.16.50 - HLA-G expression is an independent predictor for survival in high grade ovarian carcinomas Marianne J. Rutten, D. Meijer, M.R. Buist, M.J. Van de Vijver, G.G. Kenter, E.S. Jordanova; Amsterdam, Netherlands 812 P6.16.51 - Phenotypic signature of B cell subsets as a tool for the investigation of immunogenicity William J. Sanderson, E.C. Jury, J. Manson, C. Mauri; London, United Kingdom 813 P6.16.52 - Role of the immunity in the aggressive forms of breast cancer seen in Western Kenya Rispah T. Sawe; Eldoret, Kenya 814 P6.16.53 - Gastrointestinal autoimmunity to tryptophan hydroxylase in Autoimmune Polyendocrine Syndrome type 1 (APS-1) Riccardo Scarpa, R. Alaggio, L. Norberto, B. Smith, M. Plebani, F. De Luca, M. Salerno, L. Ghizzoni, C. Betterle; Padova, Italy 815 P6.16.54 - Blood pulmonary tuberculosis biomarkers on diabetic individuals Carmen J. Serrano, R.A. González, L. Enciso, N. Macías, J.A. Enciso; Zacatecas, Mexico 816 P6.16.55 - Anti-carbamylated protein antibodies (Anti-CarP) precede the onset of Rheumatoid Arthritis Jing Shi, L.A. van de Stadt, E.W.N. Levarht, T.W.J. Huizinga, D. Hamann, D. van Schaardenburg, R.E.M. Toes, L.A. Trouw; Leiden, Netherlands 817 P6.16.56 - An innovative method to identify autoantigens expressed on the cell surface: SARF T. Shirai, Hiroshi Fujii, M. Ono, R. Watanabe, Y. Shirota, S. Saito, T. Ishii, H. Harigae; Sendai, Japan 818 P6.16.57 - Significant cancer-associated autoantibody signatures for early diagnosis and prognosis of gastric cancer Karina Silina, P. Zayakin, G. Ancans, Z. Kalnina, I. Meistere, A. Pismennaya, M. Leja, A. Line; Riga, Latvia 160 Posters - August 24 819 P6.16.58 - Rates of Persistent Positivity for Anti-Cardiolipin and Anti-Beta-2-Glycoprotein I Antibodies in Routine Clinical Practice Melissa R. Snyder, M.W. Ettore; Rochester, United States 820 P6.16.59 - The effect of dipeptidyl peptidase-IV inhibitor sitagliptin on the immune functions in patients with type 2 diabetes Lucie Sromova, P. Bušek, H. Mareckova, M. Andel, A. Sedo; Prague 2, Czech Republic 821 P6.16.60 - Tonsils of patients with IgA nephropathy contain cells producing aberrantly glycosylated IgA1 and anti-glycan antibodies: implications for tonsillectomy Hitoshi Suzuki, Y. Suzuki, H. Yanagawa, Y. Makita, J. Novak, Y. Tomino; Tokyo, Japan 822 P6.16.61 - Distribution of prostate specific antigen (PSA) among senegalese men with immunoenzymatic sandwich method Maguette D. Sylla Niang, B. Mbengue, N. Dramé, M. Jalloh, I. Labou, L. Niang, G. Woto Gaye, T.N. Dièye, S. Guèye, A. Dièye; Dakar, Senegal 823 P6.16.62 - A Peptide based approach for the serological diagnosis of Chikungunya fever Priyanka Verma, D.N. Rao; New Delhi, India 824 P6.16.63 - Kinetics of expression of CD62L and CXCR3 on CD8+ T cells during treatment of hepatocellular carcinoma with TACE Yanjun Wang, J. Zheng, B. Sun, D. Liu, L. Yan; Beijing, China 825 P6.16.64 - Cord blood graft composition and its impact on clinical outcome after allogeneic stem cell transplantation Helena Wikell, J. Gertow, M. Uhlin, J. Mattsson; Stockholm, Sweden 826 P6.16.65 - Characterising the effect of remote ischaemic preconditioning on the immune response in healthy volunteers Jenni M. Williams, J. Pilcher, R. Beasley, A.C. La Flamme; Wellington, New Zealand 827 P6.16.66 - Validation of in vitro human PBMC assay to determine Lymphocytes activation of new Biotherapeutics Erika Zambello, E. Vicentini, F. Andreetta, F. Zanderigo, J. Chappell; Verona, Italy 161 Posters - August 25 Panel N° P1.07 EFFECTOR FUNCTIONS OF PHAGOCYTES Session Time: Sunday, August 25, 13:20 - 15:00 001 P1.07.01 - Diverse role of Plasmodium falciparum haemozoin towards anti-malarial innate response Selorme Adukpo, A.F. Feßer, T. Velavan; Tubingen, Germany 002 P1.07.02 - Modulation of Moraxella catarrhalis and nontypeable Haemophilus influenzae phagocytosis by neuropeptides NPY and CGRP Daria Augustyniak, J. Nowak, A. Jankowski; Wroclaw, Poland 003 P1.07.03 - Understanding innate immune functions of peripheral blood monocytes Dominic H. Banda, K.C. Jambo, D.G. Russell, R.S. Heyderman, H.C. Mwandumba; Blantyre, Malawi 004 P1.07.04 - Downregulation of dendritic cells functions by Neutrophil Extracellular Traps Lorena S. Barrientos, V. Marin-Esteban, L. de Chaisemartin, C. Sandré, R. Gorges, C. Gueguen, L. Mascarell, S. Kerdine-Römer, M. Pallardy, S. Chollet-Martin; Chatenay-Malabry, France 005 P1.07.05 - Immunological prognosing of complications of locomotors trauma Olga V. Berdugina, K.A. Berdugin; Ekaterinburg, Russian Federation 006 P1.07.06 - Monocyte subsets and immunopathology in Leishmania braziliensis infection R. Costa, S. Passos, E.M. Carvalho, Lucas P. Carvalho; Salvador, Brazil 007 P1.07.07 - Modulation of Chitinases and CLPs during Macrophage Differentiation and Polarization M. Di Rosa, Michelino Di Rosa, M. Malaguarnera, C. De Gregorio, G. Malaguarnera, L. Malaguarnera; Catania, Italy 008 P1.07.09 - Effects of aging on phagocytic activity and nitric oxide production of peritoneal macrophages from elderly mice in response to Candida albicans Taiane P. Gardizani, K.H. Pinke, H.G. Lima, V.S. Lara; Bauru, Brazil 009 P1.07.10 - Functional analyses and cytochemical staining of leucocytes from lumpsucker (Cyclopterus lumpus L.), including IgM+ cells Gyri T. Haugland, A. Rønneseth, K. Ulven, N. Vestvik, H.I. Wergeland; Bergen, Norway 010 P1.07.11 - The differences in innate immune responses of Atlantic salmon, Atlantic cod and lumpsucker Gyri T. Haugland, A. Rønneseth, H. Wergeland; Bergen, Norway 011 P1.07.12 - The effects of anabolic steroids on dendritic cells L.M. Cosgrave, E.W. Brenu, Teilah K. Huth, B. Gray, S.M. Marshall-Gradisnik; Gold Coast, Australia 012 P1.07.13 - Inflammation driven functional differentiation of human macrophages in vitro Paola Italiani, E.M.C. Mazza, S. Bicciato, C. Gemelli, A. Grande, I. Cifola, C.M. Battaglia, P. Giungato, D. Boraschi; Pisa, Italy 013 P1.07.14 - Alveolar macrophage innate immune function in HIV-infected African adults Kondwani C. Jambo, D.H. Banda, D.G. Russell, R.S. Heyderman, H.C. Mwandumba; Blantyre, Malawi 014 P1.07.15 - The influence of T4 phage preparations on the activation of human monocytes in vitro Grazyna Korczak-Kowalska, P. Wierzbicki, K. Bocian, D. Kłosowska, M. Zarzycki, J. Borysowski, M. Pacek, B. Weber-Dąbrowska, A. Górski; Warsaw, Poland 015 P1.07.16 - 12/15-lipoxygenase mediates GC-induced anti-inflammatory mechanisms in monocytes Yvonne Kusche, L. Klotz, H. Wiendl, J. Roth, K. Barczyk; Münster, Germany 016 P1.07.17 - Synthetic immunomodulatory peptides IDR-HH2, IDR-1002 and IDR-1018 regulate neutrophil functions Francois Niyonsaba, L. Madera, K. Okumura, H. Ogawa, R.E.W. Hancock; Tokyo, Japan 017 P1.07.18 - Role of Circadian Rhythm in cell metabolism and macrophage function Jacqueline Oliva, B. Pineda Olvera, O. Rojas Espinosa, F. Sánchez García; Mexico, Mexico 018 P1.07.19 - Respiratory Syncytial Virus Fusion protein stimulates neutrophil extracellular traps formation Bárbara N. Porto, R.S. Czepielewski, A.P.D. Souza, C.B.C. Bonorino, R.T. Stein; Porto Alegre, Brazil 019 P1.07.20 - An inactive chromatin configuration at the IL-10 locus in human neutrophils Nicola Tamassia, M. Zimmermann, F. Bazzoni, G. Natoli, M.A. Cassatella; Verona, Italy 162 Posters - August 25 020 P1.07.21 - Ouabain affects human monocyte activation and function Mariana P.C. Teixeira, V.M. Rumjanek; Rio de Janeiro, Brazil 021 P1.07.22 - Test-system for observing heat shock protein 70kDa (Hsp70) effect on reactive oxygen species production by immune cells Natalia Troyanova, R. Mirzoev, A. Sapozhnikov; Moscow, Russian Federation P1.08 DENDRITIC CELL SUBSETS Session Time: Sunday, August 25, 13:20 - 15:00 022 P1.08.01 - Functional limitations of plasmacytoid dendritic cells limit type I interferon, T cell responses and virus control in early life Elodie Belnoue, P. Fontannaz, C. Tougne, A. Rochat, A. Bergthaler, P. Lambert, D. Pinschewer, C. Siegrist; Geneva, Switzerland 023 P1.08.02 - The role of Dendritic Cells and Monocytes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Ekua W. Brenu, T.K. Huth, S.K. Hardcastle, L. Cosgrave, D.R. Staines, S.M. Marshall-Gradisnik; Gold Coast, Australia 024 P1.08.03 - Lag-3 expression and role in human plasmacytoid dendritic cells biology C. Camisaschi, A. De Filippo, V. Beretta, F. Rini, M. Tazzari, F. Arienti, F. Triebel, L. Rivoltini, Chiara Castelli; Milano, Italy 025 P1.08.04 - Distinct modulation of human myeloid and plasmacytoid dendritic cells by anandamide in multiple sclerosis Valerio Chiurchiu, M. Cencioni, E. Bisicchia, M. De Bardi, C. Gasperini, G. Borsellino, D. Centonze, L. Battistini, M. Maccarrone; Rome, Italy 026 P1.08.05 - NF-kB/RelA subunit plays the critical roles on the functions of plasmacytoid dendritic cells to thymus Takahiro Doi, S. Mise, T. Fukazawa; Tsukuba, Japan 027 P1.08.06 - Diminished Memory T-cell Expansion due to Delayed Kinetics of Antigen Expression by Lentivectors Karina Furmanov, A. Hovav; Jerusalem, Israel 028 P1.08.07 - Migratory behavior of dendritic cells during the development of lupus María A. Gleisner, N. Crisóstomo, C. Fuentes, P. Reyes, M. Rosemblatt, M.R. Bono; Santiago, Chile 029 P1.08.08 - Differentially activated respiratory plasmacytoid and CD11b-high dendritic cells accumulate during sublethal Klebsiella pneumonia infection Holger Hackstein, S. Kranz, A. Wachtendorf, G. Michel, J. Lohmeyer, G. Bein, N. Baal, S. Herold; Giessen, Germany 030 P1.08.09 - Analysis of the characterization of bone marrow derived dendritic subsets Kahoko Hashimoto, T. Kawasaki, T. Yamamoto, K. Takahashi, M. Kojima; Narashino City, Chiba, Japan 031 P1.08.10 - Increased tubulointerstitial recruitment of human CD141hi CLEC9A+ and CD1c+ myeloid dendritic cells in fibrotic kidney disease Andrew J. Kassianos, X. Wang, S. Sampangi, K. Muczynski, H. Healy, R. Wilkinson; Brisbane, Australia 032 P1.08.11 - Human dendritic cell subpopulations show distinct behavior in their interaction with the pathogenic mould Aspergillus fumigatus Jasmin Kungl, T. Breitschopf, S. Krappmann, H. Einsele, J. Loeffler; Wuerzburg, Germany 033 P1.08.12 - CCR2+ monocyte-derived antigen-presenting cells from the genital tract promote Th1 and Th17 immunity after HSV-2 infection Su Hyun Lee, H. Yang, M. Kweon; Seoul, Korea, Republic of 034 P1.08.13 - Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid Jérôme C. Martin, G. Bériou, M. Heslan, C. Chauvin, L. Utrianen, A. Aumenier, C. Scott, A. Mowat, V. Cerovic, S. Houston, M. Leboeuf, F. Hubert, C. Hémont, M. Merad, S. Milling, R. Josien; Nantes, France 035 P1.08.14 - Human 6-sulfo LacNAc+/CD16+ dendritic cells are distinct from Tie-2+ monocytes Alessandra Micheletti, C. Costantini, F. Calzetti, W. Vermi, M.A. Cassatella; Verona, Italy 036 P1.08.15 - Distinct subsets of dendritic cells regulate the outcome of colonic inflammation A.R.B.M. Muzaki, Christiane Ruedl; Singapore, Singapore 037 P1.08.16 - Analysis of the expression of the inhibitory receptor ILT4 on dendritic cells from systemic lupus erythematosus (SLE) patients Adriana E. Monsivais Urenda, P. Guerra de Blas, E. Zárate Hernández; San Luis Potosí, Mexico 163 Posters - August 25 038 P1.08.17 - Human conventional CD1c+ Dendritic Cells produce IL-12 and induce potent CD8+ T cell priming Giulia Nizzoli; Milan, Italy 039 P1.08.18 - Tumor cell-derived Ag cross-presentation in human DC induced by NK cells: Mechanisms and specialization of the BDCA-3+ DC subset Vincent Ollion, F. Deauvieau, A. Doffin, E. Verronese, I. Durand, J. Marvel, H. Vie, C. Caux, J. Valladeau-Guilemond; Lyon, France 040 P1.08.19 - IL-21 promotes plasmacytoid dendritic cell-NK cell cooperation through the production of granzyme B Valentina Salvi, W. Vermi, A. Cavani, S. Lonardi, T. Carbone, P. Seeger, D. Bosisio, F. Facchetti, S. Sozzani; Brescia, Italy 041 P1.08.20 - Intestinal Aldh1a2+CD103+CD8a+ DCs preferentially induce Th1 cells but not Tregs Bo-Gie Yang, E. Lee, J. Kim, M. Jang, C. Hong, M. Song, A. Kumanogoh, Y. Sung, C.D. Surh, M. Jang; Pohang, Korea, Republic of 042 P1.08.21 - Independence of ICOS-L expression on IL-10 production by DC and its impact on T cell subsets in respiratory tract infection Xiaoling Gao, J. Yang, X. Yang; Winnipeg, Canada P1.14 CYTOKINES AND OTHER REGULATORY MEDIATORS OF INFLAMMATION Session Time: Sunday, August 25, 13:20 - 15:00 043 P1.14.01 - Can Serial Quantification of IL-1 in human peripheral blood predict Outcome of fracture healing? Sabir Ali, A. Singh, A.A. Mehdi, R.N. Srivastava; Lucknow, India 044 P1.14.02 - IL-1β, IL-6 and TNF-α gene’s expressions and receptor’s mutations in ovarian cancer tissues Maha M. Arafah, M. Al-Mutairi, S. Al-Daihan, Y. Al-Anazi, M. Al-Anazi, M. Adar, A. Warsy, A. Warsy, M. Rouabhia, A. Semlali; Riyadh, Saudi Arabia 045 P1.14.03 - Relationship between selenium intake and inflammatory markers in newly-diagnosed patients with B-cell non-Hodgkin lymphoma Mourad Aribi, M. Zahzeh; Tlemcen, Algeria 046 P1.14.04 - Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of acute inflammation Makoto Arita; Tokyo, Japan 047 P1.14.05 - Fragmented but not integral collagen IV induces IL-10 in human monocytes Lourdes Andrea Arriaga-Pizano, L. Martínez-Sánchez, I. Mancilla-Herrera, A. Jiménez-Uribe, C. López-Macías, A. Isibasi; Mexico City, Mexico 048 P1.14.06 - Analysis of c reactive protein levels after an eccentric exercise Victor Barros Costa; Brasilia, Brazil 049 P1.14.07 - Immunomodulatory properties of bifidobacteria strains Jirina Bartova, A. Salakova, J. Drbohlav, P. Roubal, O. Sveda, I. Lisová; Prague, Czech Republic 050 P1.14.08 - Higher baseline tumor necrosis factor [TNF]-α and early postoperative interleukin [IL]-10 level are associated with postoperative sepsis in cardiac surgery: A preliminary study Mouna Ben Azaiz, R. Arbi, C. Romdhani, W. Ghothban, S. Haddad, I. Labbane, C. Kdous, S. Shnik, F. Mustapha, E. Ghazouani; Tunis, Tunisia 051 P1.14.09 - Early diagnostics of the slowed down bone consolidation Olga V. Berdugina, K.A. Berdugin; Ekaterinburg, Russian Federation 052 P1.14.10 - Laboratory monitoring at hip arthroplasty Olga V. Berdugina, K.A. Berdugin; Ekaterinburg, Russian Federation 053 P1.14.11 - Effect of human recombinant interleukin-33 on collagen mRNA expression in lung fibroblasts Alexander Bocharov, N. Filimonova, N. Sheveleva; Kharkov, Ukraine 054 P1.14.12 - Pro and anti-inflammatory cytokines from periferal blood mononuclear cells in elderly José Burgos, K.H. Pinke, B. Calzavara, P. Freitas-Faria, M.P.P. Nascimento, J. Venturini, V.S. Lara; Bauru, Brazil 055 P1.14.13 - Acute inflammation and anemia: hepcidin and innate immunity Maria Carrabba, M. Zarantonello, L. Duca, N. Campostrini, G. Fabio; Milan, Italy 056 P1.14.14 - SNARE proteins in the synaptic secretion of IL-12 and in tumor-induced immunosuppression of dendritic cells Giulia Chiaruttini, I. Soncin, P. Larghi, T. Galli, F. Benvenuti; Trieste, Italy 164 Posters - August 25 057 P1.14.15 - EMF Exposure Facilitates Wound Healing Events Modulating Cytokines Expression Erica Costantini, G. Vianale, C. D’Angelo, R. Muraro, M. Reale; Chieti, Italy 058 P1.14.16 - Interleukin-1β micro-environment promotes viability and proliferation of malignant glioma cell U87MG Nandakumar D Nanjaiah, H. Fathima K, P. Ramaswamy; Bengaluru, India 059 P1.14.17 - Clinical relevance of Cytokines Gene Polymorphism (CGP) in recovery of hemorrhagic shock patients Dablu L.G. D.L.G, D.N.R. D.N.Rao, S.K.B. Dr.Sanjeev; New Delhi, India 060 P1.14.19 - Acute inflammation loci influence tissue repair in mice T. Canhamero, M. Correa, J.G. Fernandes, A. Borrego, J.R. Jensen, W.H.K. Cabrera, O.G. Ribeiro, N. Starobinas, O.M. Ibañez, Marcelo De Franco; Sao Paulo, Brazil 061 P1.14.20 - Content of IL-15 in patients with myalgic encephalomyelitis / chronic fatigue syndrome Nikolay Didkovski, I. Malashenkova, I. Zuykov, O. Gurskaya, J. Sarsania, G. Kazanova, N. Hailov, D. Ogurtzov; Moscow, Russian Federation 062 P1.14.21 - Phagocytosis of apoptotic or necrotic cells differentially regulates the expression of IL-12 and IL-35 subunits in human dendritic cells Karen O. Dixon, J. O`Flynn, S. van der Kooij, C. van Kooten; Leiden, Netherlands 063 P1.14.22 - Immunoproperties of hypothalamic proline-rich polypeptides for antibacaterial immune response Andranik Durgaryan, M. Matevosyan, A. Galoyan; Yerevan, Armenia 064 P1.14.23 - Targeting NO-driven Inflammation in Human Melanoma via IL-1s and CXCL-10 Suhendan Ekmekcioglu, K. Tanese, Y. Qin, E.A. Grimm; Houston, United States 065 P1.14.24 - Interleukin 6 and interleukin 8 in maternal serum as markers of bacterial infection and preterm delivery elimir P. Eri , V. Jerant Pati , M. Bogavac, A. Pati ; Banjaluka, Bosnia and Herzegovina 066 P1.14.25 - Constitutive STAT-3 activation with maintained responsiveness to IL-6 in peripheral lymphocytes of obese women D.H. Rhodes, V. Nguyen, M.E. Sullivan, S.L. Gomez, C. Braunschweig, Giamila Fantuzzi; Chicago, United States 067 P1.14.26 - Evaluation of the immunological reactivity of blood cells in early pregnancy for predicting of pregnancy outcomes Irina Gazieva; Yekaterinburg, Russian Federation 068 P1.14.27 - Cytokine’s concentrations and monocyte HLA DR expression as markers defining the therapeutic strategy in contemporary behavior in patients with acute pancreatitis Minkov Georgi, Y. Yovtchev, A. Petrov, S. Nikolov, T. Vlaykova, K. Halacheva; Stara Zagora, Bulgaria 069 P1.14.28 - Macrophage migration inhibitory factor as a regulator of neonatal innate immune responses Eric Giannoni, M. Weier, L. Guignard, F.C.G.J. Sweep, T. Calandra, T. Roger; Lausanne, Switzerland 070 P1.14.29 - TNF-alpha, IL-4 and IL-10 cytokines induces changes in HO-1 and HDC expression in cervical cancer cells Paulina Gomez-Lomeli, P.C. Ortiz-Lazareno, A. Bravo-Cuellar, G. Hernandez-Flores, J.R. Dominguez-Rodriguez, L.F. Jave-Suarez, A. Aguilar-Lemarroy; Guadalajara, Mexico 071 P1.14.30 - To study the contribution of activated CD4+ and CD8+T cells arisen from B-T constructs of F1 and V antigens of Yersinia pestis for the antibacterial activity as an improved vaccine Geetanjali Gupta, D. Rao; Jodhpur, India 072 P1.14.31 - Resiniferatoxin exhibits anti-inflammatory property by inhibits pro-inflammatory mediators in endotoxin-challenged mice Oscar Gutierrez-Coronado, J. Viveros-Paredes, M. Miranda-Beltran, M. Perez-Vega, C. Soria-Fregozo, P. Villalobos Gutierrez; Lagos de Moreno, Mexico 073 P1.14.32 - Biomarkers of cardiovascular risk in psychiatric disorders Angelos Halaris; Maywood, United States 074 P1.14.33 - miRNAs in Sera of Tunisian Patients discriminate between inflammatory Breast Cancer and non-inflammatory Breast Cancer K. Hamdi, D. Goerlitz, M. Islam, B. Neili, F. Ben ayed, S. Chivi, C. Loffredo, I. Jilson, A. Benammar Elgaaied, J. Blancato, R. Marrakchi, Raja Triki; Tunis, Tunisia 075 P1.14.34 - Identification, function and mechanism of novel potential cytokines and membrane molecules of immune cells Wenling Han, P. Wang, D. Ma; Beijing, China 165 Posters - August 25 076 P1.14.35 - The effect of type I and III interferons on the adrenal cortex in the context of autoimmune Addison’s disease Alexander Hellesen, L. Breivik, K. Edvardsen, E. Husebye, E. Bratland; Bergen, Norway 077 P1.14.36 - Immune Senescence in an Innate Immunity Drosophila model Ana M. Hernandez, M. Tatar; Providence, United States 078 P1.14.37 - Inverse susceptibility to liver and lung carcinogenesis in mouse lines genetically selected for acute inflammatory response L.R. Carvalho, W.H.K. Cabrera, A. Borrego, A.M. Santos, O.G. Ribeiro, J.R. Jensen, N. Starobinas, M. De Franco, Olga M. Ibañez; São Paulo, Brazil 079 P1.14.38 - Platelet-activating factor enhances tumor metastasis via the reactive oxygen species-dependent protein kinase CK2-mediated NF-kB activation Suhn-Young Im, K. Kim, K. Cho, H. Kim, H. Lee, K. Jang, H. Kim; Gwangju, Korea, Republic of 080 P1.14.39 - Pathophysiological roles of the CX3CL1-CX3CR1 axis in chemical-induced skin carcinogenesis Yuko Ishida, M. Nosaka, A. Kimura, Y. Kuninaka, M. Kawaguchi, N. Mukaida, T. Kondo; Wakayama, Japan 081 P1.14.40 - Inflammatory and cytotoxic effect of silver nanoparticles on human endothelial cells Jiyoung Jang, I. Choi; Seoul, Korea, Republic of 082 P1.14.41 - Involvement of collagen receptor DDR2 in cytokine production by dendritic cells Dae-Ki Kim, B. Poudel, Y. Lee; Jeonju-city, Korea, Republic of 083 P1.14.42 - The prenylated flavonoids and 2-arylbenzofurans from the root barks of Morus alba inhibit airway inflammation Hyun Pyo Kim, H. Lim, J. Lee, H. Jin, E. Woo, S. Lee; Chunchon, Korea, Republic of 084 P1.14.43 - Dynamic cross-talk model of innate immune response to double-stranded RNA: order emerging from noisy cell responses R. Bertolusso, B. Tian, Y. Zhao, L. Vergara, A. Sabree, M. Iwanaszko, T. Lipniacki, A.R. Brasier, Marek Kimmel; Houston, United States 085 P1.14.44 - Interleukin-33 promotes proliferation of primary human lung fibroblasts A. Bocharov, Olga Kornilova; Kharkov, Ukraine 086 P1.14.45 - Features of the allergic drug reactions in Russian patients: perspectives of a DNA bank development Ilya Kukes, T. Borisova; Moscow, Russian Federation 087 P1.14.46 - HMGB1 in an experimental model of acute lung injury Cilmery S. Kurokawa, J.R. Fioretto, J.P. Araújo Junior, R.B. Pires, M.A. Moraes, R.C. Bonatto, M.F. Carpi; Botucatu, Brazil 088 P1.14.47 - Prone positioning attenuates TNF-alpha production in rabbits with lung injury under protective conventional mechanical ventilation (CMV). Cilmery S. Kurokawa, R.B. Pires, J.R. Fioretto, S.O. Klefens, J.P. Araújo, M.A. Moraes, A.M. Lousada, R.C. Bonatto, M.F. Carpi; Botucatu, Brazil 089 P1.14.48 - A potential role for the X chromosome in the CD99 expression and proinflammatory cytokine secretion in response to TLR ligands Nicolas Lefèvre, F. Corazza, J. Duchâteau, A. Delbaere, G. Casimir; Brussels, Belgium 090 P1.14.49 - Study of immunosenescence through the production of cytokines by blood monocytes Heliton G. Lima, P. Freitas-Faria, K.H. Pinke, M.P.P. Nascimento, N.A. Vieira, V.C. Porto, V.S. Lara; Bauru, Brazil 091 P1.14.50 - Roles of IL-22 in the innate immune of chronic hepatitis B Y. Zheng, Zipei Liu, M. Li, J. Zhang, Q. Jing, K. Feng, J. Zhang; Beijing, China 092 P1.14.51 - TNF, autoantibodies and soluble receptors to TNF in health and rheumatoid arthritis Julia A. Lopatnikova, E.A. Golikova, N.S. Shkaruba, A.E. Sizikov, S.V. Sennikov; Novosibirsk, Russian Federation 093 P1.14.52 - Markers of cellular damage, inflammation and apoptosis in a model of endotoxic shock J. Martinez Castillo, D. Cid Guerrero, I. Vargas Rodriguez, S.H. Sanchez Rodriguez, R.M. Ramirez Santoyo, G.G. Guerrero M, Erendira E. Lopez Robles; Zacatecas, Mexico 094 P1.14.53 - Human acidic mammalian chitinase (AMCase); molecular cloning, protein expression, and production of monoclonal antibody Kanokwan Lowhalidanon, P. Meekrathok, S. Thongsom, W. Suginta, P. Khunkaewla; NakhonRatchasima, Thailand 095 P1.14.54 - CTRP4 Plays an Important Role in Endotoxin Shock Yang Luo, W. Tan, Z. Ma, L. Wang, D. Na, X. Wu, Y. Chen, Y. Zhang, D. Ma, L. Wang; Beijing, China 166 Posters - August 25 096 P1.14.55 - Endothelial cells enhances chemokines and reduces inflammatory cytokines release by human monocyte in vitro Ismael Mancilla-Herrera, J. Alvarado-Moreno, S. Estrada-Parra, C. López-Macías, A. Isibasi, L. Arriaga-Pizano; Mexico City, Mexico 097 P1.14.56 - Pro-inflammatory cytokines analysis in HPV-positive cancer cells Giorgio Mangino, S.M. Zangrillo, V.M. Chiantore, M. Iuliano, M. Severa, G. Fiorucci, E.M. Coccia, G. Romeo; Latina, Italy 098 P1.14.57 - IL-6, IL-6sr, TNF-α, IL-10 and IL-8 levels in patients with chronic periodontitis after periodontal therapy Patrizzia Mastromatteo-Alberga, M. Correnti, L. Escalona; Caracas, Venezuela, Bolivarian Republic of 099 P1.14.58 - Deficiency of IL-10/IL-12 cytokine exacerbate systemic inflammatory responses in renal injury induced by ischemia and reperfusion Vanessa Nunes de Paiva, R. M. M. Monteiro, R. Assumpção Larocca, P. Semedo, M. A. dos Reis, A. Pacheco-Silva, N. O. S. Câmara; Sao Paulo, Brazil 100 P1.14.59 - HMG-CoA reductase inhibitor simvastatin improves organ dysfunction, inflammatory profile, bacterial clearance and cognitive damage after onset of sepsis Flora M.J. Oliveira, C.F. Gonçalves-de-Albuquerque, I.M. Medeiros-de-Moraes, P.A. Reis, P.T. Bozza, F.A. Bozza, A.R. Silva, H.C. CastroFaria-Neto; Rio de Janeiro, Brazil 101 P1.14.60 - Human mesenchymal stem cell adherence and invasivity in vitro after transfection with CD29 specific siRNA Carmen Panaitescu, L. Marusciac, F. Bojin, V. Paunescu; Timisoara, Romania 102 P1.14.61 - In vitro effect of Interleukin-33 on gastric adenocarcinoma cell line (AGS) and intestinal epithelial cancer cell line (Caco-2) Laura F. Pisani, L. Pastorelli, N. Munizio, M. Vecchi; Milan, Italy 103 P1.14.62 - In silico design of cytokine-trap peptides for modulation of the IL-13 signalling pathway in asthma Nicola J. Purdy, W. Walker, J.G.L. Mullins; Swansea, United Kingdom 104 P1.14.63 - Chemokines and biomarkers of endothelial dysfunction in chronic urticaria Ilaria Puxeddu, F. Panza, F. Pratesi, D. Bartaloni, V. Rocchi, I. Del Corso, P. Migliorini; Pisa, Italy 105 P1.14.64 - Role of Cytokine Response in Disease Progression and Severe Clinical Outcomes in Leptospirosis E.A.G. Reis, J. Hagan, G.S. Ribeiro, A.T. Carvalho, O.A. Martins-Filho, R.R. Montgomery, A.C. Shaw, A.I. Ko, Mitermayer G. Reis; Salvador/Ba- Brazil, Brazil 106 P1.14.65 - IL-33 signaling modulates the development of adriamycin-nephropathy Vanessa O. Reis, J. Nogueira-Neto, B.C. Vivanco, A.C. Keller; São Paulo, Brazil 107 P1.14.67 - Nitric Oxide tightly regulates Dendritic Cells life cycle and cytokines release under inflammatory conditions Chiara Ripamonti, S. Baldassarri, C. Storini, D. Miglietta, M. Foti; Milano, Italy 108 P1.14.68 - Correlation of magnesium levels with inflammatory markers in thiazide induced hypomagnesemic rats Sarah Sadiq, A. Naveed, T. Ahmed, S. Khan; Islamabad, Pakistan 109 P1.14.69 - Anti-inflammatory, immunostimulatory and antiviral effects of Coffee fruit (Coffea arabica) Fátima B. Saldaña Morales, I.A. Lozada Requena, D.F. Zegarra Ruiz, S.R. Dávila Paico, M.A. Cabello Napuri, J.L. Aguilar Olano; Lima, Peru 110 P1.14.70 - Proinflammatory Effect of the P2X7 Receptor during Sepsis Patricia T. Santana, C.F. Benjamim, C. Takiya, C. Caruso-Neves, R. Coutinho-Silva; Rio de Janeiro, Brazil 111 P1.14.71 - Role and correlation of inflammatory cytokines, angiogenic markers and insulin growth factors in post treatment (neoadjuvant chemoradiation) disease mapping in advanced stage carcinoma of uterine cervix Manoj Sharma, R. Khan, M. Aggarwal, A. Sharma; New Delhi, India 112 P1.14.72 - S100A8 and S100A9 induce the expression of cytokines and regulate the NLRP-3 inflammasome via ROS-dependent activation of NF-κB Jean-Christophe C. Simard, A. Cesaro, M. Tardif, F. Antoine, P.A. Tessier, D. Girard; laval, Canada 113 P1.14.73 - Mice selected for maximal inflammatory response display a higher lung inflammation induced by Tityus serrulatus scorpion venom P.G. Lara, T.R. Narcizo, A.F. Machado, V.D. Aiello, L.A. Benvenuti, F.C.V. Portaro, O.A. Sant Anna, N. Starobinas, O.G. Ribeiro, Monica Spadafora-Ferreira; São Paulo, Brazil 114 P1.14.74 - Melaleuca alternifolia and its main component, terpinen-4-ol, inhibit the production of IL-1β, IL-6, IL-4 and IL-10 by activated monocytes Denise P. Spolidorio, M.N. Nogueira, T. Bedran, M.F. Correia, L. Barbosa, C. Rossa Junior; Araraquara, Brazil 167 Posters - August 25 115 P1.14.75 - Inflammatory responses to low volume high load and high volume medium load protocols during dynamic leg press exercise Johanna K. Stenholm, S. Walker, G. Paulsen, K. Häkkinen, W.J. Kraemer, M. Hämäläinen, K. Vuolteenaho, E. Moilanen, A.A. Mero; Jyväskylä, Finland 116 P1.14.76 - Cytokines profile in a social defeat animal model of depression and effects of a novel anti-asthenic drug ladasten Anna V. Tallerova, L. Kovalenko, O. Kuznetsova, A. Durnev, S. Seredenin; Moscow, Russian Federation 117 P1.14.77 - sICAM-1 and sUPAR as Immune Markers for Treatment Response in Ethiopian TB-Patients with and without HIV Co-Infection Wegene Tamene, D. Kassa, Y. Alemayehu, G. Gebremicheal, A. Alemu, T. Messele; Addis Ababa, Ethiopia 118 P1.14.78 - State of adaptive mucosal immunity among immunocompromised patients with allergic rhinosinusitis Nataly Tataurshchikova; Moscow, Russian Federation 119 P1.14.79 - High sensitivity C-reactive protein and insulin levels in obese and non-obese patients with polycystic ovarian syndrome Sadaf S. Uppal, A. Naveed, A. Majeed; Islamabad, Pakistan 120 P1.14.80 - HMGB1 is a major mediator of pathology in mice surviving sepsis Sergio I. Valdes-Ferrer, M. Rosas-Ballina, B. Lu, P.S. Olofsson, J. Roth, D.J. Antoine, U. Andersson, K.J. Tracey; Manhasset, United States 121 P1.14.81 - Association of polymorphism of TNF-alpha receptors genes with expression levels of membrane-bound receptors and serum levels of soluble receptors Filipp F. Vasilyev, S.V. Sennikov, J.A. Lopatnikova, A.N. Silkov; Novosibirsk, Russian Federation 122 P1.14.82 - Comparison of cytokine production in human lymphocytes and human tissue culture THP 1 stimulated by metallic ions Zora Venclikova, J. Bartova, J. Belacek; Prague, Czech Republic 123 P1.14.83 - TNF and IL-10 in a bitter-sweet battle in taste buds P. Feng, J. Chai, L. Huang, Hong Wang; Philadelphia, United States 124 P1.14.84 - The role of Notch signaling in IL-12 production in murine macrophages Wipawee Wongchana, B.A. Osborne, N. Boonyatecha, N. Sangphech, T. Palaga; Bangkok, Thailand 125 P1.14.85 - Cortex Magnolia Officinalis extract prevents gastric ulcer by stimulating CB2 gene expression and reducing IL-6 and TNF-alpha productions in stomach tissue Mei-Li Wu, H. Chaung, M. Hsieh, C. Chen, H. Chiu; Pingtung, Taiwan 126 P1.14.86 - An essential role for eosinophils in neutrophil accumulation in response to eotaxin Pedro P. Xavier-Elsas, R.A. Luz, L.C.G. Arcanjo, A.C. Faria, M.C. Gaspar-Elsas; Rio de Janeiro, Brazil 127 P1.14.87 - Interleukin-1 signaling prevents bacteremia in enteric infection with Citrobacter rodentium H. Yang, Mi-Na Kweon; Seoul, Korea, Republic of 128 P1.14.88 - IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages Y. Sato, H. Hara, S. Suzuki, T. Kaisho, Hiroki Yoshida; Saga, Japan P1.16 COMPLEMENT SYSTEM Session Time: Sunday, August 25, 13:20 - 15:00 129 P1.16.01 - Transcript levels of complement regulatory proteins (CD35 and CD59) in rheumatoid arthritis patients and their relationship with disease activity and prognosis Devyani Anand, U. Kumar, M. Kanjilal, S. Kaur, N. Das; New Delhi, India 130 P1.16.02 - Anti-mitochondria antibodies type 2 and neurological manifestations: Report of 5 cases Imen Ayadi, L. Laadhar, M. Kallel Sellami; Tunis, Tunisia 131 P1.16.03 - Immunotoxicity of work environment exposure in some welders: implications for occupational health Bosun Banjoko; Ile-Ife, Nigeria 132 P1.16.04 - Hereditary C1 esterase inhibitor deficiency in Tunisia: a seven years laboratory experience Ahlem Ben Hmid, H. Jouini, Y. Zerzeri, J. Sassi, L. Laadhar, M. Sallemi, S. Makni; Tunis, Tunisia 133 P1.16.05 - Humoral Immunity in the healthy population of the central region of Cuba L.C. Bequer Mendoza, T. Gómez Hernández, L. Salazar Torres, L. Perez de Alejo Rodriguez, V. Hernández Moreno, L. Molina Hernández, Oliver Perez; Santa Clara. Villa Clara, Cuba 168 Posters - August 25 134 P1.16.06 - Whole exome sequencing in a Finnish family with hereditary angioedema with normal C1 inhibitor Laura J. Bouchard, H. Jarva, A. Laukkanen, M.J. Savolainen, S. Meri; Helsinki, Finland 135 P1.16.07 - Effect of immune complex and cytokines on expression and modulation of neutrophil complement regulatory proteins in SLE Nibhriti Das, B. Biswas, U. Kumar, V. Arora, A. Kumar; New Delhi, India 136 P1.16.08 - Contribution of C5a measurement to explain some clinical biological discrepancies in monitoring of lupus Kamel Djenouhat, A. Tahiat, M. Boucelma; Algiers, Algeria 137 P1.16.09 - Complement activation in patients with systemic lupus erythematosus without nephritis A. Tahiat, Kamel Djenouhat, M. Boucelma, M.C. Abbadi; Algiers, Algeria 138 P1.16.10 - MASP2 and MBL: Dynamics and Intrathecal synthesis Alberto J. Dorta-Contreras, B. Padilla Docal, A. Arias Morales, O. Pérez, H. Reiber, J.C. Jensenius; Havana, Cuba 139 P1.16.11 - Human skin-derived mast cells express complement C3 and C5 Yoshihiro Fukuoka, M. Hite, A. Dellinger, L.B. Schwartz; Richmond, United States 140 P1.16.12 - Probiotic spores: a missing link between innate immunity and nutritional health E. Saball, M. Salvarrey, J. Moreno, N. Abraham, Roberto R. Grau; Rosario, Argentina 141 P1.16.13 - Hereditary complement C8 deficiency in a Turkish family found in a girl with recurrent meningitis and her asymptomatic sister Nesrin Gulez, F. Genel, L. Skattum, L. Truedsson; Izmir, Turkey 142 P1.16.14 - Complement component C3 variant (R102G) and the risk of neovascular age realated macular degeneration in a Tunisian population Imen Habibi, I. Sfar, A. Chebil, F. kort, R. Bouraoui, R. Limaiem, S. Ayed, T. Ben Abdallah, L. El Matri, Y. Gorgi; Tunis, Tunisia 143 P1.16.15 - The Yersinia pestis Outer Membrane Protein Ail Recruits C4b-Binding Protein Leading to Factor I-Mediated Inactivation of Covalently and Non-covalently Bound C4b Derek K. Ho, M. Skurnik, A. Blom, S. Meri; Helsinki, Finland 144 P1.16.16 - Neutralizing complement resistance improves cell-mediated killing (CDCC) of HER2 positive breast cancer cells by Trastuzumab and Pertuzumab S. Mamidi, S. Höne, Michael Kirschfink; Heidelberg, Germany 145 P1.16.17 - Dissecting the modular nature of properdin using recombinant thrombospondin repeats TSR4 and TSR5 Lubna Kouser, M. Abdul-Aziz, R.B. Sim, A.G. Tsolaki, U. Kishore; London, United Kingdom 146 P1.16.18 - Comparison of C3 and C4 with CH50 in North West of Iran Behzad Mansoori, A. Osali; Tabriz, Iran, Islamic Republic of 147 P1.16.19 - Myeloperoxidase directly interacts with properdin and induces alternative pathway complement activation Joseph O`Flynn, K. Dixon, M.C. Faber Krol, M.R. Daha, C. van Kooten; Leiden, Netherlands 148 P1.16.20 - Marine algae Bostrychia tenella fractions and extracts from associated endophytic microorganisms modulate the complement system J.C. Pereira, C.G. Nogueira-Santos, T.M.C. Ogasawara, R. de Felício, H.M. Debonsi, Luciana S. Pereira-Crott; Ribeirão Preto, Brazil 149 P1.16.21 - Developmental programming of low levels of C3 and C4 complement factors by gestational chronodisruption Jose M. Sarmiento, N. Mendez, H. Galdames, C. Spichiger, M. Seron-Ferre, H. Folch, C. Torres-Farfan, H. Richter; Valdivia, Chile 150 P1.16.22 - Dietary restriction and fasting downregulate complement activity via MBL-pathway Shushimita Shushimita, P. van der Pol, R. W. F. de Bruin, J. N. M. IJzermans, C. van Kooten, F. J. M. F. Dor; Rotterdam, Netherlands P2.06 LEUKOCYTE TRAFFICKING Session Time: Sunday, August 25, 13:20 - 15:00 151 P2.06.01 - CCL17 deficiency is associated with beneficial CNS immune responses and prevents cognitive decline in a mouse model of Alzheimer’s disease K. Neitzert, Ö. Albayram, R. Göhrs, I. Karaca, A. Ramirez, J. Walter, F. Jessen, W. Maier, A. Zimmer, Judith Alferink; Bonn, Germany 169 Posters - August 25 152 P2.06.02 - T-cell immunoglobulin- and mucin-domain-containing molecule (Tim)-1 is a novel physiological ligand for P-selectin controlling activated T cell trafficking under inflammatory conditions Stefano Angiari, T. Donnarumma, B. Rossi, G. Piacentino, S. Dusi, S. Xiao, V.K. Kuchroo, P.D. Rennert, G. Constantin; Verona, Italy 153 P2.06.03 - Expression and function of selectins during human development in utero Kaisa Auvinen, S. Jalkanen, M. Salmi; Turku, Finland 154 P2.06.04 - Susceptibility of Mycobacterium tuberculosis-infected CCR4 deficient mice is associated with a balance between lymphocytes and Foxp3+ regulatory cells Thaís B. Bertolini, A.R. Piñeros, R.Q. Prado, A.F. Gembre, J.C. Alves Filho, V.L. Bonato; Ribeirão Preto, Brazil 155 P2.06.05 - Pivotal role of Ccr1 in murine lupus nephritis Alexandre Bignon, F. Gaudin, P. Hémon, H. Tharinger, P. Loetscher, M. Peuchmaur, D. Berrebi, K. Balabanian; Clamart, France 156 P2.06.06 - Local and systemic effects of chronic peritonitis induced by pristane in the absence of galectin-3 Camila Brand, F.L. Oliveira, T.P. Costa, F.E.P.L. Abreu, R. Borojevic, R. Chammas, M.C. El-Cheikh; Rio de Janeiro, Brazil 157 P2.06.07 - CCR5-dependent T cell migration contribute to squamous cell carcinoma development C.E. Oliveira, T.H. Gasparoto, C.R. Pinheiro, K.A. Cavassani, G.P. Garlet, J.S. Silva, Ana P. Campanelli; Bauru, Brazil 158 P2.06.08 - The absence of chemokine signalling via CCR5 impairs sepsis outcome Fernanda V.S. Castanheira, F. Sonego, A. Kanashiro, P.G. Czaikoski, T.M. Cunha, J. Alves-Filho, F.Q. Cunha; Ribeirão Preto, Brazil 159 P2.06.09 - Melatonin regulates the migration of granulocytes into mouse peritoneal cavity via MT2 receptor Vitalij Cernysiov, M. Mauricas, I. Girkontaite; Vilnius, Lithuania 160 P2.06.10 - CLEVER-1 as a cell trafficking molecule Johannes Dunkel, P. Rantakari, M. Karikoski, O. Schulz, O. Pabst, S. Jalkanen; Turku, Finland 161 P2.06.12 - Phenotypic characterization of CLEVER-1 knock-out mice Kati Elima, M. Karikoski, P. Rantakari, M. Salmi, S. Jalkanen; Turku, Finland 162 P2.06.13 - Studies on the human primary amine oxidase/sialic acid binding Ig-like lectin -9 and -10 interactions Heli Elovaara, V. Parkash, R. Fair-Mäkelä, E. Bligt-Lindén, T.A. Salminen, S. Jalkanen; Turku, Finland 163 P2.06.14 - A novel role for GIRK channels in the immune system Erez S. Garty, A. Kaminitz, A. Ben-Nun, E. Reuveny; Rehovot, Israel 164 P2.06.15 - Integrin alpha 4 differentially affect the homing of effector and regulatory T cell subsets Simon Glatigny, R. Duhen, C. Arbelaez, S. Kumari, M. Oukka, E. Bettelli; Seattle, United States 165 P2.06.16 - Contribution of L-selectin to activated CD4 and CD8 T cell migration into dermal inflammation Thomas B. Issekutz; Halifax, Canada 166 P2.06.17 - Podoplanin (Aggrus)-bound CCL21 regulates adhesive migration of T lymphocytes on the cell surfaces of lymphatic endothelium Caname Iwata; Tokyo, Japan 167 P2.06.18 - TCR-Induced Activation of LFA-1 Involves Signaling through Tiam1 Farhana A. Jahan, M. Grönholm, C.G. Gahmberg; Helsinki, Finland 168 P2.06.19 - 17-parameter flow cytometry: immunophenotyping cellular infiltration during flavivirus encephalitis in the mouse T.M. Ashhurst, C. van Vreden, M. Karimi Azardaryany, K. Lundsten, S. Allen, S. Dervish, F. Kao, A. Smith, Nicholas Jonathan Cole King; Sydney, Australia 169 P2.06.20 - CD69 expression and leukocyte distribution in CD69-BAC transgenic mice Teresa Laguna, L. Notario, P. Lauzurica; Majadahonda, Spain 170 P2.06.21 - Induction of cytosolic phospholipase A2α is required for adipose neutrophil infiltration and hepatic insulin resistance early in the course of high fat feeding Rachel Levy, N. Hadad, O. Burgazliev, V. Elgazar carmon, A. Rudich; beer-Sheva, Israel 171 P2.06.22 - Deficiency of the leukocyte integrin inhibitor, Del-1 exacerbates experimental autoimmune encephalomyelitis through increased Th17 cells infiltration Jong-Hyung Lim; Dresden, Germany 170 Posters - August 25 172 P2.06.23 - Possible role of Myo1g in vesicular traffic of different molecules of B lymphocytes Orestes López-Ortega, J. Maravillas-Montero, G. Patiño-López, S. Shaw, L. Santos-Argumedo; México DF, Mexico 173 P2.06.24 - AChR-specific T cell trafficking in the thymus of chronic Experimental Autoimmune Myasthenia Gravis Roberta Marolda, C. Cordiglieri, P. Cavalcante, P. Bernasconi, R. Mantegazza, F. Baggi; Milan, Italy 174 P2.06.25 - Role of CD38 in regulating the migration of B cells in Chronic Lymphocytic Leukemia Silvia Mele, S. Devereux, A. Ridley; London, United Kingdom 175 P2.06.26 - The autotaxin/lysophosphatidic acid is a regulator of lymphocyte extravasation at the high endothelial venules of lymph nodes Masayuki Miyasaka, E. Umemoto, A. Takeda, Z. Bai, L. Cai, E. Hata, K. Tohya, Y. Komai, P. Veeraveedu, Y. Sugiura; Suita, Japan 176 P2.06.27 - Langerhans cell penetration through the epidermal- dermal barrier Christine Moussion, M. Sixt; Klosterneuburg, Austria 177 P2.06.28 - Identification and Characterization of a Monocyte CXCL4 Receptor J.M. Fox, F. Kausar, A. Day, M. Osbourne, A. Mueller, T. Tsuchiya, S. Kanegasaki, James E. Pease; London, United Kingdom 178 P2.06.29 - Involvement of CXCR3 and CXCR4 in natural killer cell trafficking into bone marrow during multiple myeloma growth Andrea Ponzetta, G. Benigni, F. Antonangeli, G. Sciumè, G. Bernardini, A. Santoni; Rome, Italy 179 P2.06.30 - Natural posttranslational modification of CXC chemokines modifies their in vitro and in vivo activity Paul Proost, A. Mortier, E. Moelants, T. Loos, M. Gouwy, S. Struyf, G. Opdenakker, J. Van Damme; Leuven, Belgium 180 P2.06.31 - Non-hematopoietic endothelial LSP1 orchestrates CXCL2-sensitive motile neutrophil functions in vivo Syed M. Qadri, M. Hossain, N. Xu, L. Liu; Saskatoon, Canada 181 P2.06.32 - Sphingosine-1-phosfate receptors are involved in cell migration in T-cell acute lymphoblastic leukemia and lymphoma Carolina V.M. Rachid, J.P. Lemos, W. Savino, D.A. Mendes-da-Cruz; Rio de Janeiro, Brazil 182 P2.06.33 - A new mTOR-dependent, Akt-independent pathway differentiates the migratory behavior of regulatory and conventional T cells Giorgio Raimondi, L.C. Chen, B.R. Rosborough, A.W. Thomson; Baltimore, United States 183 P2.06.34 - Role of oxysterol EBI2 ligand pathway in inflammation Andrea Reboldi, T. Yi, J.G. Cyster; San Francisco, United States 184 P2.06.35 - CR3 and CR4 differently mediate the adherence to fibrinogen of human dendritic cells Noémi Sándor, C. Kriston, A. Erdei, Z. Bajtay; Budapest, Hungary 185 P2.06.36 - Angiotensin II-induced vascular dysfunction depends on aortic infiltration and mutual activation of NK cells and monocytes Melanie Schwenk, S. Kossmann, M. Hausding, M. Knorr, M.I. Schmidgen, S.H. Karbach, A. Daiber, T. Münzel, P. Wenzel, C. Becker; Mainz, Germany 186 P2.06.37 - Morphometric analysis of the distribution of decidua NK cells and macrophages in the neighborhood of the trophoblast invasion front Peter Sedlmayr; Graz, Austria 187 P2.06.38 - Endothelial- specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo Ruth Seelige, C. Natsch, S. März, D. Jing, M. Frye, S. Butz, D. Vestweber; Muenster, Germany 188 P2.06.39 - PI3Kgamma confers resistance against Trypanosoma cruzi infection due to its important role in microbicidal activity of macrophages Maria C. Silva, R. Sesti, F.C. Dias, T.S. Medina, G.K. Silva, J.C.A. Filho, F.Q. Cunha, J.S. Silva, T.M. Cunha; Ribeirão Preto, Brazil 189 P2.06.40 - Nr4a1-dependent Ly6Clow monocytes monitor endothelial cells and orchestrate their disposal in the presence of nucleic acids L.M. Carlin, Efstathios Stamatiades, C. Auffray, R.N. Hanna, L. Glover, G. Vizcay-Barrena, C.C. Hedrick, H.T. Cook, S. Diebold, F. Geissmann; London, United Kingdom 190 P2.06.41 - Simultaneous analysis of multiple fluorescent proteins and fluorochromes by a novel spectral flow cytomete Micho Tomura, K. Futamura, M. Furuki; Kyoto-city, Japan 171 Posters - August 25 191 P2.06.42 - The atypical chemokine receptor D6 is mobilized from recycling endosome for adaptive up-regulation and chemokine degradation through a β-arrestin1/myosinVb-dependent mechanism Alessandro Vacchini, E.M. Borroni, C. Cancellieri, A. Mantovani, M. Locati, R. Bonecchi; Rozzano, Italy 192 P2.06.43 - LFA-1 is critical for T-cell mediated protective immunity elicited by heterologous prime-boost vaccination strategy against a systemic parasitic infection F. Virgilio, M. Mariana R. Dominguez, A. V. Machado, O. Bruna–Romero, R. Ricardo T. Gazzinelli, M. M. Rodrigues, José Ronnie C. Vasconcelos; São Paulo, Brazil 193 P2.06.44 - TNFR2 induces IRF-1 dependent IFNβ autocrine signaling in endothelial cells to promote monocyte recruitment Deepak Venkatesh, T. Ernandez, F. Rosetti, I. Batal, X. Cullere, F. Luscinskas, Y. Zhang, G. Stavraki, G. García-Cardeña, B. Horwitz, T. N Mayadas; Boston, United States 194 P2.06.45 - Role of CBAP in chemokine-induced zap70-mediated T-cell trafficking Y. Chiang, K. Ho, K. Ho, C. Sun, J. Chiu, F. Lee, F. Liao, H. Yang-Yen, Jeffrey J. Yen; Taipei, Taiwan P2.09 MHC AND OTHER POLYMORPHIC GENES IN HEALTH AND DISEASE Session Time: Sunday, August 25, 13:20 - 15:00 195 P2.09.01 - New genetic variants of the CCR5 gene in the Omani population Ali A. Al-Jabri, S.H. Al-Mahroqi; Muscat, Oman 196 P2.09.03 - Possible involvement of polymorphisms in OAS2, OAS3, and CD209 genes, associated with severe forms of tick-borne encephalitis, in predisposition to hepatitis C in Russian population Andrey Barkhash, G. Kochneva, E. Chub, S. Mikhaikova, A. Romaschenko; Novosibirsk, Russian Federation 197 P2.09.04 - Role of paired immunoglobulin-like receptor B (PirB) and T CD8 lymphocytes during axonal regeneration following peripheral axotomy André L. Bombeiro, S.L.O. Nunes, B.M. Moreira, A.L.R. Oliveira; Campinas, Brazil 198 P2.09.05 - Possible roles of MICA and NKG2D and their interaction in the pathogenesis of autoimmune Addison’s disease Eirik Bratland, A. Hellesen, K. Edvardsen, E.S. Husebye; Bergen, Norway 199 P2.09.06 - Cross-presentation in renal transplant recipients Eytan Breman, P.P. van Miert, D. Roelen, F.H. Claas, C. van Kooten; Leiden, Netherlands 200 P2.09.07 - MHC Class I expression in hematopoietic and non-hematopoietic cells regulates NK cell licensing and viral control Michael G. Brown, H. Wei; Charlottesville, United States 201 P2.09.08 - KIR-HLA interactions during pregnancy impact their population frequencies Jorg J.A. Calis, C. Kesmir; Utrecht, Netherlands 202 P2.09.09 - HLA-B*46:01 associated with oncogenic HPV persistence Hui-Chi Chen, Y. Chen, M. Pan, C. Lin, S. You, C. Chen; Taipei, Taiwan 203 P2.09.10 - Haplotypes of the HLA-G gene are associated TD1 R. S. de Albuquerque, N. Lucena-Silva, C.L. Silva, E. Castelli, Eduardo Donadi, C. Mendes-Junior; Ribeirao Preto, Brazil 204 P2.09.11 - Regulation of MHC class II expression in cancer cell lines involves the RNA binding protein EBP1 L. Pisapia, A. Cortese, P. Barba, Giovanna Del Pozzo; Naples, Italy 205 P2.09.12 - Major Histocompatibility Complex related LEI0258 allelic segregation in chicken Atefeh Esmailnejad, G. Nikbakht, F. Amini, N. Khazeni Oskoui; Tehran, Iran, Islamic Republic of 206 P2.09.13 - Motifs of the naturally processed peptides presented by HLA-A*24:07 Marsia Gustiananda, D. Cox, C. McMurtrey, K.W. Jackson, D. Mojsilovic, W. Bardet, S. Cate, J. Yaciuk, S. Kaabinejadian, W.H. Hildebrand; Jakarta, Indonesia 207 P2.09.14 - Superior detection of antigen specific CD4+ T-cells using pMHC-II tetramers with altered C-terminal peptide flanking residues Christopher J. Holland, G. Dalton, D.K. Cole, A. Godkin; Cardiff, United Kingdom 208 P2.09.15 - Genetic variants of suppressor molecule BTLA in susceptibility to prostate cancer Lidia Karabon, A. Szczepanska, K. Tupikowski, A. Partyka, A. Tomkiewicz, A. Wojciechowski, E. Pawlak, J. Dembowski, R. Zdrojowy, I. Frydecka; Wroclaw, Poland 172 Posters - August 25 209 P2.09.16 - Association of HLA-G polymorphisms with gastric adenocarcinoma risk and clinical outcome Samaneh Khorrami, R. Malekzadeh, H. Poustchi, R. Rahimi, A. Zavaran Hosseini; Tehran, Iran, Islamic Republic of 210 P2.09.17 - Frequencies of insertion/deletion polymorphism in HLA-G gene in non-small cell lung cancer patients and healthy controls in a Polish population sample Piotr Kusnierczyk, A. Wisniewski, R. Jankowska, A. Kowal, I. Porebska; Wroclaw, Poland 211 P2.09.18 - Association study among HLA, KIR, MICA, PARK2, and cytokine genes in patients with leprosy from Southern Brazil Priscila S. Mazini, D.S.A. Franceschi, C.C.C. Rudnick, P.G. Reis, M.T. Mira, A.M. Sell, V.M. Fava, J.E.L. Visentainer; Maringá, Brazil 212 P2.09.19 - Association of MICA gene with the development of chronic chagasic cardiopathy P.G. Reis, C.M. Ayo, C.F. Oliveira, Priscila S. Mazini, A.M. Sell, M.M.O. Dalalio, J.E.L. Visentainer; Maringá, Brazil 213 P2.09.20 - MIC and NKG2D genes polymorphism in Mexican population Miriam E. Nieves-Ramirez, E. Bravo-Flores, P.E. Alegre-Crespo, M. Tapia-Lugo, M.E. Perez-Rodriguez; Mexico City, Mexico 214 P2.09.21 - Association between the HLA-G molecule and lymph node metastasis in papillary thyroid cancer Larissa M. Nunes; El Paso, United States 215 P2.09.22 - MHC class I chain related gene A polymorphism and gastroduodenal lesions in Mexican population infected by Helicobacter pylori Oswaldo Partida-Rodriguez, M.E. Nieves-Ramirez, L. Flores, E. Lazcano, J. Torres, M.E. Perez-Rodriguez; Mexico City, Mexico 216 P2.09.23 - CTLA-4 and CD28 gene polymorphisms in renal cancer in the Polish population Anna M. Partyka, K. Tupikowski, L. Karabon, A. Kolodziej, R. Zdrojowy, A. Tomkiewicz, I. Frydecka; Wroclaw, Poland 217 P2.09.24 - Optimization of T-cell antigens for vaccine development Johanne Pentier, G.M. Dolton, J. Ekeruche, M. Clement, D.K. Cole, J.J. Miles, D.M. Lewinsohn, D.A. Price, L. Wooldridge, A.K. Sewell; Cardiff, United Kingdom 218 P2.09.25 - The HLA-DRB1*01 allele confers genetic susceptibility to lepromatous leprosy in Mexicans Rosalio Ramos-Payan, M. Escamilla-Tilch, N.M. Torres-Carrillo, M. Aguilar-Medina, M.I. Salazar, M. Fafutis-Morris, R. ArenasGuzmán, S. Estrada-Parra, I. Estrada-García, J. Granados; Culiacan, Sinaloa, Mexico 219 P2.09.27 - HLA-DRB1*11 is associated with Papillon-Lefevre Syndrome in Mexican patients carrying a novel cathepsin C mutation Jose G. Romero-Quintana, M. Aguilar-Medina, L.O. Frías-Castro, J.E. Dueñas-Arias, E. Arámbula-Meraz, J.G. Romero-Navarro, R. Ramos-Payán; Culiacan, Sinaloa, Mexico 220 P2.09.28 - Influence of TIM-1 haplotypes on CD4 counts in HIV seroprevalent North Indians Gaurav Sharma, G. Kaur, A. Kimura, T. Nakajima, H. Ohtani, T. Naruse, S.K. Sharma, M. Vajpayee, N.K. Mehra; New Delhi, India 221 P2.09.29 - Association studies of functional ICOS gene polymorphisms with schizophrenia disease in the Polish population Anna M. Tomkiewicz, L. Karabon, A.M. Partyka, D. Frydecka, A. Kiejna, A. Beszlej, I. Frydecka; Wroclaw, Poland 222 P2.09.30 - Change of C/A at the SNP −592 of human IL-10 gene increase serum IL-10 levels in patients with cervical lesions and cervical cancer Kirvis J. Torres Poveda, M. Bahena Román, A. Lagunas Martínez, K. Delgado Romero, D. Cantú, A. García Carrancá, V. Madrid Marina; Cuernavaca, Mexico 223 224 P2.09.31 - Comparison of the distribution of two promoter single nucleotide polymorphisms, -725C>G>T and -716T>G, in non-small cell lung cancer and healthy population sample Andrzej Wisniewski, R. Jankowska, A. Kowal, I. Porebska, M. Wagner, P. Kusnierczyk; Wroclaw, Poland P2.09.32 - Associations of IFN-alpha genetic variation with the functional phenotype of T subsets Jou-Hui Yu, H. Chang, Y. Li, M. Wu, W. Chung, H. Chaung; Pingtung, Taiwan P3.04 GENETIC REARRANGEMENTS OF LYMPHOCYTE RECEPTORS Session Time: Sunday, August 25, 13:20 - 15:00 225 P3.04.01 - Construction and functional activity of fibronectin scaffold containing different chains of hypervariable complementarity determining regions of mouse antibody against human IgG4 Gregory V. Brovman, L.E. Petrovskaya, T.A. Yagudin, E.V. Svirshchevskaya; Moscow, Russian Federation 226 P3.04.02 - Bi-polarized function of the 3’ regulatory region at the immunoglobulin heavy chain locus F. Braikia, D. Haddad, A. Khamlichi, Caroline Conte; Toulouse, France 173 Posters - August 25 227 P3.04.03 - Specification of the Vκ gene repertoire at the mouse Ig gene locus Y. Xiang, S. Park, William T. Garrard; Dallas, United States 228 P3.04.04 - Reassessing HLA-DRB3, DRB4 and DRB5 expression in different cell types Europa A. Gonzalez-Navarro, R. Faner, E. Rigol-Monzó, X. Coll, E. Garcia, N. De Moner, L. Carretero, D. Archila, M. Juan; Barcelona, Spain 229 P3.04.05 - Intrinsic bias and public rearrangements in the human immunoglobulin VLambda light chain repertoire Kam Hon Hoi, G. Ippolito, G. Georgiou; Austin, United States 230 P3.04.06 - Defects in VDJ recombination and thymocyte development induced by T cell-specific deletion of protein phosphatase 4/PP4 E. Hsing, F. Liao, W. Hsou, Y. Lin, Y. Jhou, Ching-yu Huang; Zhunan, Miaoli County, Taiwan 231 P3.04.07 - XLF is required for the generation of junctional diversity by TdT Hanna IJspeert, I. Jerchel, R. Leite, N.S. Verkaik, J.J.M. van Dongen, D.C. van Gent, M. van der Burg; Rotterdam, Netherlands 232 P3.04.08 - High throughput sequencing data reveals the shape of the immunoglobulin repertoire Katherine J.L. Jackson, A.M. Collins; Sydney, Australia 233 P3.04.09 - Identifying factors responsible for maintenance of immunoglobulin class switch recombination Michael X. Le, S. Ramachandran, R.M. Nepal, A. Chopra, T. Ketela, J. Moffat, A. Martin; Toronto, Canada 234 P3.04.10 - Detection Of Interferon Alpha Receptor 2 in Interferon Resistant HCV Patients Suhail R. Marazi, A. Rashid, Q. Bashir; Rawalpindi, Pakistan 235 P3.04.11 - In vivo analysis of Aicda gene regulation: critical balance between upstream enhancer and intronic repressor for the appropriate expression L. Huong, M. Kobayashi, M. Nakata, G. Shioi, H. Miyachi, T. Honjo, Hitoshi Nagaoka; Gifu, Japan 236 P3.04.12 - T-cell receptor (TCR) profiling by next-generation sequencing Tal Oron, L. Marchand, Q. Li, C. Polychronakos; Montreal, Canada 237 P3.04.13 - AID expression in pancreas promotes an inflammatory response Arantxa Pérez-García, P. Pérez-Durán, F. X Real, A. Ramiro; Madrid, Spain 238 P3.04.15 - T cell receptor repertoire plasticity in peripheral CD8 T cells Paul G. Thomas, G. Wang, J.L. McClaren, M.Y. Morris, P.C. Doherty, P. Dash; Memphis, United States P3.05 ANTIGEN PROCESSING AND PRESENTATION Session Time: Sunday, August 25, 13:20 - 15:00 239 P3.05.01 - Hypoxia directly enhances dendritic cell antigen presentation Sistiana Aiello, F. Rocchetta, N. Azzollini, P. Cassis, S. Solini, M. Mister, G. Remuzzi, M. Noris; Ranica, Italy 240 P3.05.02 - Synthetic immunoactive fragments of Survivin: selection and application for monomer and dimer detection Elena V. Akhidova, M.V. Kalintseva, T.D. Volkova, I.Y. Yakupov, D.O. Koroev, L.E. Zavalishina, O.M. Volpina; Moscow, Russian Federation 241 P3.05.03 - The impact of sub-cellular localization, dose, and expression pattern of tumour antigen on cross-presentation efficiency Chidozie Anyaegbu, S. Fisher, R.A. Lake, B.W.S. Robinson; Perth, Australia 242 P3.05.04 - High resolution mass spectrometry reveals unanticipated depth and diversity of HLA peptidomes Michal Bassani-Sternberg, M. Mann; Martinsried, Germany 243 P3.05.05 - Tumor associated MUC1 carried by microvesicles is cross-processed by Dendritic cells generating immunogenic MUC1 glycoepitopes and is cross-presented to CD8+T cells Federico Battisti, H. Rahimi, F. Belleudi, C. Napoletano, I. Zizzari, M. Antonilli, V. Visconti, F. Bellati, M. Nuti, A. Rughetti; Rome, Italy 244 P3.05.06 - Differential antigen-dependency of CD4+ and CD8+ T cells Anne C. Behrendt, H. Rabenstein, J. Ellwart, M. Horsch, J. Beckers, R. Obst; Munich, Germany 245 P3.05.07 - Immunoproteasome induction and MHC class I molecules presentation in motor neurons of a familial Amyotrophic Lateral Ssclerosis mouse model G. Nardo, R. Iennaco, M. Trolese, Caterina Bendotti; Milan, Italy 174 Posters - August 25 246 P3.05.08 - In vitro study of Thyroglobulin peptides associated to HLA-DR3 under thyroid antigen presentation conditions Teresa Ciudad, A. Kim, J. Alonso, E.A. James, W.W. Kwok, S. Sadegh-Nasseri, D. Jaraquemada; Cerdanyola del Valles, Spain 247 P3.05.09 - Epitopes of 21-hydroxylase targeted by autoreactive T cells in patients with autoimmune Addison’s disease are also targeted by T cells in mice immunized with 21-hydroxylase protein Kine Edvardsen, E. Bratland, A. Hellesen, E.S. Husebye; Bergen, Norway 248 P3.05.10 - Sub-optimal antigen presentation of CD8+ T cell epitopes by dendritic cells infected with Trypanosoma cruzi Jonatan Ersching, K.R. Bortoluci, M.M. Rodrigues; São Paulo, Brazil 249 P3.05.11 - Bone marrow endothelial cells of patients with multiple myeloma: antigen presenting functions and T cell regulation Arianna Ferrucci, P. Leone, R. Ria, V. Racanelli, A. Vacca; Bari, Italy 250 P3.05.12 - Inhibition of ERAP1 function promotes human NK cell immune responses against tumors: an innovative strategy of anticancer immunotherapy L. Cifaldi, P. Romania, D. Pende, F. Locatelli, Doriana Fruci; Rome, Italy 251 P3.05.13 - Human mesenchymal stromal cells derived from cervical neoplasisas down-regulate the expression of HLA class I molecules on cervical cancer cells Rosario García-Rocha, J.J. Montesinos, M.L. Mora-García, M.C. Moreno-Lafont, M.E. Castro-Manreza, B. Weiss-Steider, A. Monroy-García; México, Mexico 252 P3.05.14 - Effect of MBA on therapeutic protein immunogenicity Tal Gefen, J. Vaya, S. Khatib, D. Heller, E. Aizenstein, J. Pitcovski; Kiryat Shmona, Israel 253 P3.05.15 - Identification of gliadin peptides restricted by the HLA Class I B8 encoded by B*0801 allele in linkage with the celiac disease-associated DR3-DQ2 haplotype S. Picascia, J. Sidney, A. Camarca, G. Mazzarella, A. Sada, G. Iaquinto, S. Auricchio, A. Sette, R. Troncone, Carmen Gianfrani; Avellino, Italy 254 P3.05.16 - Identification of inducible lymphoid structures in the skin: a key site to elicit contact hypersensitivity responses Y. Natsuaki, G. Egawa, S. Nakamizo, S. Hanakawa, T. Hashimoto, Y. Miyachi, Kenji Kabashima; Kyoto, Japan 255 P3.05.17 - Novel antigenic MHC class I peptides are generated and presented in the absence of tapasin Takayuki Kanaseki, K. Camfield, N. Shastri, N. Sato; Sapporo, Japan 256 P3.05.18 - On the role of heparan sulfates in antigen cross-presentation Delphine Knittel, A. Savatier, J. Boulain, M. Léonetti; Gif-sur-Yvette, France 257 P3.05.19 - Porcine leukocyte antigen-derived peptides that are presented by human MHC molecules Chong-Kil Lee, C. Park, K. Kim, S. Im; Cheongju, Korea, Republic of 258 P3.05.20 - A new a high throughput method to assess quantitative and qualitative differences in the antibody response Alessandra Mariani, F. Buricchi, G. Volpini, S. Budroni, A. Di Domenico, F. Castellino, G. Del Giudice, D. Medini, O. Finco; Siena, Italy 259 P3.05.22 - Citrullination of myelin antigens increases binding to Multiple Sclerosis associated MHC class II molecules and enhances T cell responses Patrick C. Merky, M. Khademi, N. Abdelmagid, E.A. James, S. Haag, T. Olsson; Stockholm, Sweden 260 P3.05.23 - Thromboxane A2 controls primary T cell - DC interactions in vivo Federica Moalli, P. Halbherr, M. Pieczyk, S. Narumiya, J. Stein; Bern, Switzerland 261 P3.05.24 - Independent transport of MHC class II and H2-DM to processing compartments and convergence with molecules of distinct trafficking pathways Jonathan Cortés Alvarez, G. Pérez-Montesinos, C. Sánchez, L.C. Bonifaz, J. Moreno; Cuernavaca, Mexico 262 P3.05.25 - Ultrastructure of human autologous macrophage lymphocyte rosettes in Chagas disease Ivon T.C. Novak, A.D. Orquera; Cordoba, Argentina 263 P3.05.26 - The non-classical class II genes of the chicken, DMA and DMB, are similar to those of mammals, but a second DMB gene (DMB1) is differentially expressed with unusual regulatory and structural features Aimée Parker, K. Staines, C. Butter, J. Kaufman; Cambridge, United Kingdom 264 P3.05.28 - The wild-type hemochromatosis protein HFE inhibits MHC I antigen presentation Alexandre Reuben, M. Phénix, M.M. Santos, R. Lapointe; Montréal, Canada 175 Posters - August 25 265 P3.05.29 - Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells V. Tardif, Sebastián A. Riquelme, S. Remy, L.J. Carreño, T. Simon, C.A. Riedel, P. Blancou, S. Bueno, I. Anegon, A.M. Kalergis; Santiago, Chile 266 P3.05.31 - Stable antigen is most effective for eliciting CD8+ T cell responses after DNA vaccination and infection with recombinant vaccinia virus in vivo Christopher Schliehe, A. Bitzer, M. van den Broek, M. Groettrup; Vienna, Austria 267 P3.05.32 - The Mer Receptor Tyrosine Kinase promotes B-cell antigen processing through the IgD B-cell Receptor Wen-Hai Shao, Y. Zhen, F. Finkelman, P. Cohen; Philadelphia, United States 268 P3.05.33 - Genetic Regulation of the Bovine Immune System and Implications for Health Kathleen Thompson-Crispi, R. Ventura, F. Schenkel, F. Miglior, B. Mallard; Guelph, Canada 269 P3.05.34 - The influence of MHCII haplotypes on T cell priming and disease development in a chronic model of rheumatoid arthritis Jonatan Tuncel, S. Haag, D.E. Mason, S. Thordardottir, A.C.Y. Yau, E.C. Peters, R. Holmdahl; Stockholm, Sweden 270 P3.05.35 - Stem-cell transplantation restores CD8 T-cell immunity and corrects MHC class I deficiency Anthony P. Williams, Y. Gao, R. Carter, A. Cazaly, S.I. Khakoo, A. Mant, A.J. Cant, S. Gadola, P.D. Arkwright, T.J. Elliott; Southampton, United Kingdom 271 P3.05.36 - Systematic analysis of the antigen processing machinery in HPV-positive cell lines Jan Winter, A. Steinbach, K.M. Grabowska, A.K. Grabowska, A.B. Riemer; Heidelberg, Germany P3.08 TH1 AND TH2 CELLS Session Time: Sunday, August 25, 13:20 - 15:00 272 P3.08.01 - Chemokine receptor (CKR) expression on memory CD4+ Th2 cells in mice during an allergen-mediated exacerbation of allergic asthma Berislav Bosnjak, M.M. Epstein; Vienna, Austria 273 P3.08.02 - The role of CD244 in regulating M. tuberculosis antigen-specific CD4+ T cell function Xiaoxing Cheng, B. Yang, J. Jiang, X. Wang; Beijing, China 274 P3.08.03 - Dose-dependent differential effects of thrombin in allergic bronchial asthma Corina D’Alessandro-Gabazza, Y. Matsushima, A.L. Chelakkot Govindalayathil, Z. Roeen, T. Takagi, T. Yazuma, T. Kobayashi, M. Toda, E.C. Gabazza; Tsu, Japan 275 P3.08.04 - Serine protease inhibitor characteristics of human T helper 2 cells Sanna M. Edelman, T. Äijö, I. Koho, H. Kallionpää, S. Tuomela, R. Lahesmaa; Turku, Finland 276 P3.08.05 - New column-free procedure for the enrichment of human Th1(CD4+CXCR3+) cells from peripheral blood Maureen Fairhurst, J. Yu, S. de Jong, T. Thomas; Vancouver, Canada 277 P3.08.06 - Identification and characterization of the secreted form of TMEM98 that promotes Th1 cell differentiation both in vitro and in vivo Weiwei Fu, Y. Zhang, Y. Cheng, P. Wang, T. Li, W. Pan, D. Ma, W. Han; Beijing, China 278 P3.08.07 - NFκB attenuates IL-5 production and upregulates T-box transcription factors in Th2-like T cells Masaaki Hashiguchi, A. Kobayashi, Y. Kashiwakura, H. Kojima, Y. Kanno, T. Kobata; Tochigi, Japan 279 P3.08.08 - T-lymphocytes effectors/memory cells detection by intracellular cytokines staining in children of different age and adults Julia G. Lagereva, J.B. Beykin; Ekaterinburg, Russian Federation 280 P3.08.09 - Generation of mutants forms of mite allergen Der p 5 with reduce IgE binding Sadjia Lahiani, S. Khemili, A. Bouaziz, I. Bitam, D. Gilis, M.E. Dumez, M. Galleni; Liège, Belgium 281 P3.08.10 - The role of neuronal adhesion molecule AMIGO2 in T cell function and inflammatory diseases Zhilin Li, J. Kuja-Panula, H. Rauvala, L. Tian; Helsinki, Finland 282 P3.08.11 - IL-27 regulates Th1 lymphocytes and induces Th17-dependent protection against experimental Trypanosoma cruzi infection Tiago Medina, G.K. Silva, D. Fonseca, R. Sesti, M.C. Silva, J.S. Silva; Ribeirao Preto, Brazil 176 Posters - August 25 283 P3.08.12 - IL-4 receptor alpha signalling on dendritic cells is required for optimal Th2 responses in house dust mite induced allergic airway disease and schistosomiasis Natalie E. Nieuwenhuizen, H.H. Ndlovu, F. Kirstein, R. Hurdayal, F. Brombacher; Berlin, Germany 284 P3.08.13 - Differential mechanisms of contact hypersensitivity development to dinitrochlorobenzene (DNCB) in rats Aleksandra Popov Aleksandrov, I. Mirkov, J. Djokic, M. Ninkov, D. Miljkovic, D. Kataranovski, M. Kataranovski; Belgrade, Serbia 285 P3.08.14 - A novel strategy for integrating gene expression profiles derived from multiple publicly available datasets highlights novel hub genes and pathways in mouse models of allergic asthma MIchela Riba, J.M. Garcia-Manteiga, B. Bosnjak, M.M. Epstein, E. Stupka; Milan, Italy 286 P3.08.15 - Expression of cytokines and transcription factors in CD4+ T cell in myasthenia gravis V. Yilmaz, P. Oflazer, F. Aysal, Y.G. Parman, F. Deymeer, Güher Saruhan-Direskeneli; Istanbul, Turkey 287 P3.08.16 - MiRNA expression and function in CD4 T cells from asthmatic airways Laura J. Simpson, G. Seumois, P. Vijayanand, P. Woodruff, M. Ansel; San Francisco, United States 288 P3.08.17 - Differences in the polarization of the inflammatory response of patients with chronic obstructive pulmonary disease (COPD) secondary to smoking and to biomass smoke exposure Helena Solleiro-Villavicencio, M.I. Vargas-Rojas, A. Ramírez- Venegas, R.H. Sansores-Martínez, M. Velázquez-Uncal, O. Pérez-Bautista, R. Quintana, R. Falfán-Valencia, I. Pupko-Sissa; Mexico City, Mexico 289 P3.08.18 - Transgenic Expression of Survivin Compensates the OX40-Deficiency in Driving Th2 Development and Allergic Inflammation Jim Song, D. Lei, R. Haque; Hershey, United States 290 P3.08.19 - Resistin, Tumor Necrosis Factor-α and Insulin Resistance in Normal Pregnancy Abdolreza Sotoodeh Jahromi, F. Mehdizadeh; Jahrom, Iran, Islamic Republic of 291 P3.08.20 - Identifying the T helper cell population involved in class-switching to IgE Sharrada Subramaniam, J. He, L. Jones, M. Curotto de Lafaille; Singapore, Singapore 292 P3.08.21 - Retrogenic expression of human TCR in HLA-DR4 transgenic NOG mice Takeshi Takahashi, I. Katano, R. Ito, M. Ito; Kawasaki, Japan 293 P3.08.22 - The effect of toll-like receptor 4 on the development of acquired immunity against Salmonella infection Panagiotis Tourlomousis, P. Mastroeni, K.A. Fitzgerald, D.J. Maskell, C.E. Bryant; Cambridge, United Kingdom 294 P3.08.23 - Formation of the utero-(pre) placental blood flow in pregnant women with threatened abortion in early pregnancy due to impaired immune-hormonal homeostasis Iryna I. Voronova, T.N. Demina; Donetsk, Ukraine 295 P3.08.24 - Myofibroblast Apoptosis, Removal from the Lungs and Attenuation of Fibrosis by FasL+ Immune Cells Shulamit B. Wallach-Dayan, L. Elkayam, R. Golan-Gerstl, R. Breuer; Jerusalem, Israel 296 P3.08.25 - Impact of immunosuppressive drugs on killing capacity and cytokine production of BKV-specific T cells Benjamin J.D. Weist; Berlin, Germany 297 P3.08.26 - Bromodomain-Containing-Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells Joe, poh sheng Yeong, W. Zhang, P. Celine, C. Sum, N. Thiessen, S. Jones, S. Pettersson, S. Knapp, H. Yang, K. Chin; Singapore, Singapore - Moved to August 26 in P2.12: Signaling in immune cells in pag. 205 298 P3.08.27 - Effect of extremely low frequency electromagnetic field (ELF-EMF) on some cytokines production of rats Alireza Zamani, I. Salehi, K. Ghazikhanlou Sani; Hamadan, Iran, Islamic Republic of P3.13 REGULATORY T CELLS: BASIC ASPECTS Session Time: Sunday, August 25, 13:20 - 15:00 299 P3.13.01 - Increased CD8+ regulatory T cells in breast cancer F. Riazi-Rad, Z. Saraf, R. Omranipour, M. Alimohammadian, Soheila Ajdary; Tehran, Iran, Islamic Republic of 300 P3.13.02 - Regulatory T cells during tumor development in the APCmin/+ mouse model of colon cancer Paulina Akeus, V. Langenes, A. von Mentzer, S. Raghavan, M. Quiding-Järbrink; Gothenburg, Sweden 177 Posters - August 25 301 P3.13.03 - Asymptomatic Leishmania major-infected individuals exhibit lower frequency of regulatory T cells compared to the healed individuals Mohammad Hossein Alimohammadian, F. Bahrami, H. Darabi, F. Riazi-Rad, V. Khaze, S. Ajdary; Tehran, Iran, Islamic Republic of 302 P3.13.04 - Analysis of the Treg cell proteome by differential quantitative mass spectrometry Melanie Barra, D. Richards, J. Hansson, M. Delacher, J. Krijgsveld, M. Feuerer; Heidelberg, Germany 303 P3.13.05 - Association between SNP rs 2234711 and tuberculosis Behnoush Beiranvand, S. abediankenari, M. Rezaei, E. beiranvand; Ahvaz, Iran, Islamic Republic of 304 P3.13.06 - Prolactin Effect in Cd4+Cd25hicd127low/- Regulatory T Cell Function in Human Francisco Blanco-Favela, V. Legorreta-Haquet, K. Chávez-Rueda, E. Montoya-Diaz, L. Chavez-Sanchez, L. Arriaga-Pizano, E. ZentenoGalindo; México City, Mexico 305 P3.13.07 - Regulatory T-cells of mouse display distinctive surface glycosylation patterns and enhanced responsiveness to lectin-induced proliferation Joana Cabral, S. Hanley, J. Gerlach, L. Lokesh, T. Ritter, R. Ceredig, M.D. Griffin; Galway, Ireland 306 P3.13.08 - Immunological consequences of HIV co-infection with M. Leprae Karina I. Carvalho, F.R. Bruno, J. Tomimori, L. Nogueira, E. Moreira, E. Cunha-Neto, M.B. Xavier, J. Kalil, D. Nixon, E.G. Kallas; São Paulo, Brazil 307 P3.13.09 - PDCD5 negatively regulates autoimmunity by upregulating FOXP3+ regulatory T cells and suppressing Th17 and Th1 responses J. Xiao, C. Liu, G. Li, J. Hu, Y. Zhang, D. Ma, Yingyu Chen; Beijing, China 308 P3.13.10 - The endocannabinoid 2-Arachidonoylglycerol potentiates Foxp3 expression and Regulatory T cell functions through its metabolism Valerio Chiurchiu, M. Lanuti, M. De Bardi, N. Battista, E. Bisicchia, G. Borsellino, M. Maccarrone, L. Battistini; Rome, Italy 309 P3.13.11 - Altered expression of miR-146a and miR-155 in Th2 and IgG expressing B cells in the autoimmune disease pemphigus foliaceus Gabriel A. Cipolla, M. Petzl-Erler; Curitiba, Brazil 310 P3.13.12 - DX5+ CD4+ T cells modulate CD4+ T-cell response via inhibition of IL-12 production by DCs Hanane el Bannoudi, W.G. Han, J.N. Stoop, P. Louis-Plence, T.W.J. Huizinga, R.E.M. Toes; Leiden, Netherlands 311 P3.13.13 - T regulatory cells in cancer Eyad Elkord; Al Ain, United Arab Emirates 312 P3.13.14 - Regulatory T cells in acute lymphoblastic leukemia Mariana H. Garcia Hernandez, S. Godina Gonzalez, M.N. Medina Rosales; Zacatecas, Mexico 313 P3.13.15 - T Lymphocyte-mediated suppression of murine granulopoiesis by oral allergen pretreatment of sensitized/challenged mice Maria Gaspar-Elsas, T. Queto, B. de Luca, B. Vieira, C.L.C.A. Silva, R.A. Luz, R. Ferreira, P.P. Xavier-Elsas, D. Masid-de-Brito; Rio de Janeiro, Brazil 314 P3.13.16 - Augmented levels of CD4+CD25high Treg cells in peripheral blood of patients with acute and chronic brucellosis Hadi Ghazanfari, N. Hassannejad, A. Bahador, A. Bahador, J. Hajati; Isfahan, Iran, Islamic Republic of 315 P3.13.17 - Association of circulating regulatory T cell number with the incidence and prognosis of diffuse large B cell lymphoma Magdalena Głowala-Kosi ska, A. Chwieduk, J. Nieckula, M. Sadu -Wojciechowska, S. Grosicki, A. Rusin, E. Nowara, S. Giebel; Gliwice, Poland 316 P3.13.18 - Maintenance of memory regulatory T cells in peripheral tissues Iris K. Gratz, M.D. Rosenblum, H. Truong, M.M. Maurano, A.K. Abbas; San Francisco, United States 317 P3.13.19 - Beta2 adrenergic receptor signaling in CD4+ Foxp3+ regulatory T cells enhances their suppressive function in vitro Marcia G. Guereschi, L.P. Araujo, J.T. Maricato, M.C. Takenaka, V.M. Nascimento, B.C. Vivanco, V.O. Reis, A.C. Keller, A.S. Basso; São Paulo, Brazil 318 P3.13.20 - Role of cutatneous regulatory T cells in regulation of immune homeostasis and contact hypersensitivity reaction in the skin Sho Hanakawa, A. Kitoh, Y. Miyachi, K. Kabashima; Kyoto, Japan 319 P3.13.21 - Genome-wide DNA methylation profiling identifies hypomethylated genes with the Forkhead-binding motif in human regulatory T cells Y. Zhang, J. Maksimovic, G. Naselli, J. Qian, M.E. Blewitt, A. Oshlack, Leonard C. Harrison; Melbourne, Australia 178 Posters - August 25 320 P3.13.22 - Identification of PLAU as a critical gene for the suppressive function of memory-like CD4+ regulatory T cells Feng He, H. Chen, M. Probst-Kepper, R. Geffers, S. Eifes, A. del Sol, K. Schughart, A. Zeng, R. Balling; Esch-Belval, Luxembourg 321 P3.13.23 - CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied by downregulation of Bim Yuji Kashiwakura, D. Sakurai, Y. Kanno, M. Hashiguchi, A. Kobayashi, A. Kurosu, S. Tokudome, T. Kobata, H. Kojima; Mibu, Shimotsuga, Tochigi, Japan 322 P3.13.24 - Diurnal changes in trafficking receptor expression on thymus-deriving natural regulatory T cells Ewelina Kiernozek, A. Kowalik, K. Niedzielska, M. Markowska, N. Drela; Warsaw, Poland 323 P3.13.25 - Dexamethasone dose-dependent effect on nTreg generation in vitro in thymocytes co-cultures with JAWSII cells Anna Kowalik, K. Gugala, E. Kiernozek, E. Kozlowska, N. Drela; Warsaw, Poland 324 P3.13.26 - Donor-specific regulatory t cells generated on donor b cells are superior to CD4+CD25high cells in controlling alloimmune responses in humanized mice Young-Seon Lee, F. Noyan, M. Hardtke-Wolenski, A. Knoefel, R. Taubert, U. Baron, M.P. Manns, E. Jaeckel; Hannover, Germany 325 P3.13.27 - TIP60 Positively Regulates ThPOK-Mediated Repression of Eomesodermin in Human CD4+ T Cells Bin Li, Y. Li; Shanghai, China 326 P3.13.28 - The effects of 5-azacytidine on the enhancement of CD4+CD25highFOXP3+ T cells from the cultures of human CD4+CD25- T cells Chun-Hao Lu, C. Wu, M. Kuo; Taoyuan, Taiwan 327 P3.13.29 - Ctirical roles of the transcriptional regulator IκB-ζ in regulatory T cells Takashi Maruyama, T. Muta; Sendai, Japan 328 P3.13.30 - Differential sialylation dictates the fate of regulatory T cells Santiago P. Mendez Huergo, T. D´Alotto Moreno, M. Toscano, J.P. Cerliani, D.O. Croci, K. Mariño, G.A. Rabinovich; Buenos Aires, Argentina 329 P3.13.31 - Thymic precursors of T regulatory cells are resistant to caspase/granzyme B mediated degradation of Linker for activation of T cells M. Klossowicz, B. Scirka, K. Marek-Bukowiec, P. Kisielow, Arkadiusz Miazek; Wroclaw, Poland 330 P3.13.32 - Effect of gestational age and mode of delivery on CD4+ T cells and regulatory T cells (Treg) in neonatal cord blood Dhriti Mukhopadhyay, L. Weaver, R. Tobin, D. Jupiter, M.K. Newell-Rogers, L. Perger; Temple, United States 331 P3.13.33 - Adenosine production through CD39 and CD73 mediates development of sepsis-induced immunossupression via A2a receptor Daniele C.B. Nascimento, P.H. Melo, R.G. Ferreira, R.S. Peres, D.S. Zamboni, F.Q. Cunha, J.F. Alves-Filho; Ribeirão Preto, Brazil 332 P3.13.34 - CD4+ regulatory T lymphocytes in preeclamptic women and in their newborns: preliminary results David Felipe Navarro Barquín, L. Daza Benitez, S. López Briones, A. Macías Rocha, P. González; León de los Aldamas, Mexico 333 P3.13.35 - The influence of regulatory T cells on the response to the measles and DTP vaccines in Gambian infants Jorjoh Ndure, F. Noho-Konteh, J. Adetifa, S. Rowland-Jones, E. Clarke, J. Sutherland, H. Whittle, M. Plebanski, M. Ota, K. Flanagan; Banjul, Gambia 334 P3.13.36 - Homeostatic competition of regulatory T cells in the peripheral compartment of syngeneic and semi-allogeneic hosts Jeane S. Nogueira, C.F.C.G. Nunes, F.B. Canto, P.H.O. Vianna, M.M.C. Ferreira, A. Nóbrega, M. Bellio, R. Fucs; Rio de Janeiro, Brazil 335 P3.13.37 - Regulatory T cells are preferentially preserved over non-Tregs within neonatal-derived T cells present in adult mice Caroline F. Nunes, J.S. Nogueira, F.B. Canto, P. Vianna, M. Martins, M. Bellio, A. Nóbrega, J. Mengel, R. Fucs; Rio de Janeiro, Brazil 336 P3.13.38 - Identification of an endogenous subpopulation of regulatory CD8+ T cells specific for a tissue-restricted tumor associated antigen in tumor-bearing TRAMP mice Sara Martina Parigi, N. Rigamonti, E. Degl’Innocenti, E. Jachetti, M. Grioni, M. Bellone; Milan, Italy 337 P3.13.39 - CD39 is highly involved in mediating the suppressive activity of tumor-infiltrating CD8+ T regulatory lymphocytes Alessia Parodi, F. Battaglia, F. Kalli, F. Ferrera, G. Conteduca, G. Borgonovo, P. Traverso, G. Carmignani, D. Fenoglio, G. Filaci; Genova, Italy 338 P3.13.40 - The hunt for a natural regulatory T cell ligand Matt Phillips, J. Scott-Browne, J. Kappler, P. Marrack; Denver, United States 179 Posters - August 25 339 P3.13.41 - CD8+ regulatory T cells recognize donor MHC class II-derived immunomodulatory epitopes in an allotransplantation model E. Picarda, S. Bézie, A. Delhumeau, K. Renaudin, E. Mérieau, I. Anegon, Carole Guillonneau; Nantes, France 340 P3.13.42 - Interferon-alpha plays complex roles in human regulatory T cell deprogramming into Th1-like cells Silvia Piconese, Y. Pacella, E. Timperi, D. Accapezzato, G. Labbadia, V. Barnaba; Rome, Italy 341 P3.13.43 - Inducible IL-10 secreting CD49b+Treg cells as cell based-therapy for rheumatoid arthritis Julie Quentin, R. Vicente, D. Martire, A. Mausset-Bonnefont, C. Jorgensen, P. Louis-Plence; Montpellier, France 342 P3.13.44 - Systems analysis of innate activation reveals IL-1 family members as key modulators of T cells susceptibility to regulation and novel targets for therapeutic intervention Giorgio Raimondi, Y.T. Nicholson, C. Ziraldo, R. Starzl, S. Schneeberger, A.W. Thomson, G. Brandacher, Y. Vodovotz; Baltimore, United States 343 P3.13.45 - CD39 expression on Treg cells is genetically determined and can be further modulated upon activation Anne Rissiek, A. Cuapio, I. Baumann, A. Dodge-Khatami, P.C. Arck, F. Koch-Nolte, F. Haag, E. Tolosa; Hamburg, Germany 344 P3.13.46 - ART2 blockade during cell preparation preserves the vitality and function of Tregs and iNKT cells Björn Rissiek, W. Danquah, F. Haag, F. Koch-Nolte; Hamburg, Germany 345 P3.13.47 - miR-21 transfection can differentiate human naïve T cells to regulatory phenotype Eisa Salehi, H. Namdari, M. Ghayedi, P. Rahimzadeh, S. Mortezagholi, Z. Gheflati, J. Hajati, B. Dolatshah Earaghi; Tehran, Iran, Islamic Republic of 346 P3.13.48 - Nr4a nuclear orphan receptors are essential for thymic regulatory T cell development and immune homeostasis Takashi Sekiya, A. Yoshimura; Tokyo, Japan 347 P3.13.49 - CD8+CD122+CD49d- regulatory T cells maintain immune homeostasis by Fas/FasL pathway-mediated killing of activated T cells Haruhiko Suzuki, K. Akane, K. Isobe; Nagoya, Japan 348 P3.13.50 - Regulatory T cells in peripheral blood and tissue of active generalized vitiligo Manoj K. Tembhre, V.K. Sharma, A. Sharma, P. Chattopadhyay, S. Gupta; New Delhi, India 349 P3.13.51 - Characterization of the role of hydroxyprostaglandin dehydrogenase in regulatory T cells Yasser Thabet, E. Schönfeld, M. Mai, T. Sadlon, K. Subbaramaiah, A.J. Dannenberg, T. Sparwasser, S.C. Barry, J.L. Schultze, M. Beyer; Bonn, Germany 350 P3.13.52 - Regulatory T cell plasticity in HCV-related liver inflammation and tumor Eleonora Timperi, Y. Pacella, M. Rossi, G. Grazi, S. Brozzetti, V. Barnaba, S. Piconese; Roma, Italy 351 P3.13.53 - Application of novel Brilliant Violet™ fluorophores for multicolor flow cytometric analysis: phenotyping of regulatory T cells and conventional T cell subsets by surface and intracellular staining Carsten Wiethe, E. Tolosa, D. Nguyen, J. Ransom, C. Monell, X. Xiang, N. Jiang, G. Lay; San Diego, United States 352 P3.13.54 - PPAR-alpha deficiency modulates Treg cell functions and contributes to inhibit tumor growth in mice Akadiri Yessoufou, A. Hichami, F. Salvadori, K. Moutairou, W. Wahli, N.A. Khan; Cotonou, Benin P4.01 IMMUNITY TO VIRUS INFECTION Session Time: Sunday, August 25, 13:20 - 15:00 353 P4.01.001 - T-and B-cell responses to human rhinovirus infection Alar Aab, W. van de Veen, S. Söllner, O. Wirz, B. Stanic, M. Akdis, C. Akdis; Davos Platz, Switzerland 354 P4.01.002 - Tax-1-mediated HTLV-1 replication and NF-kB activation is inhibited by the MHC-II transactivator CIITA R. Abdallah, G. Forlani, Roberto S. Accolla, G. Tosi; Varese, Italy 355 P4.01.003 - Detection of the autoimmunity in primary Epstein-Barr virus infection by indirect immunofluorescence A. Sener, Ilhan Afsar, H. Er, B. Karaayak Uzun, S. Kaya; Izmir, Turkey 356 P4.01.004 - Human cytomegalovirus UL141 targets the TRAIL death receptors to inhibit host NK cell responses Rebecca J. Aicheler, P. Tomasec, W. Smith, E.C.Y. Wang, R.J. Stanton, C.A. Benedict, G.W. Wilkinson; Cardiff, United Kingdom 357 P4.01.005 - ERAP deficiency leads to absence of anti-influenza immune response to known immunodominant HLA-B27 peptide Ali Akram, R. Inman; Toronto, Canada 180 Posters - August 25 358 P4.01.006 - NF-kappaB1 is required for virus-specific CD8+ T cell responses, and prevents excessive inflammation and lethality during chronic infection Cody C. Allison, R. Gugasyan, S.P. Preston, J.P. Cooney, J.G. Toe, G. Ebert, M. Pellegrini; Melbourne, Australia 359 P4.01.007 - CD56+CD3+ T cells in relation to CMV infection in normal subjects and kidney transplant patients Mazen M. Almehmadi, S. Christams, B. Flangan, S. Heyworth, A. Hammad; Liverpool, United Kingdom 360 P4.01.008 - Involvement of NK cells in the acute lung injury of H1N1 influenza infection X. Zhang, W. Deng, L. Bao, M. Wen, B. Cao, C. Wang, Yunqing An; Beijing, China 361 P4.01.009 - Human cytomegalovirus viral IL-10 polarizes monocytes towards a deactivated M2c phenotype to repress host immune responses Selmir Avdic, J.Z. Cao, B.P. MsSharry, L.E. Clancy, R. Brown, M. Steain, D.J. Gottlieb, A. Abendroth, B. Slobedman; Sydney, Australia 362 P4.01.010 - Quantitation of mRNA cytokine levels in ferrets following influenza infection L.A. Carolan, J. Butler, S. Rockman, A.C. Hurt, A. Kelso, Ian G. Barr, K.L. Laurie; North Melbourne, Australia 363 P4.01.011 - Reproducibility of Pentamer and Streptamer staining of CMV-specific CD8+ T-cells: defining the optimal multimer concentration and incubation conditions Lorea Beloki, N. Ramirez, M. Ciaurriz, C. Mansilla, A. Zabalza, E. Bandres, M. Rodriguez-Calvillo, E. Olavarria; Pamplona, Spain 364 P4.01.012 - KIR2DL2 overexpression influences NK cell response to CpG Daria Bortolotti, A. Rotola, D. Di Luca, R. Rizzo; Ferrara, Italy 365 P4.01.013 - HLA-G influences nasal polyp relapse in HPV positive patients R. Rizzo, Daria Bortolotti, N. Malagutti, V. Gentili, A. Rotola, T. Pezzolo, C. Fabbri, C. Aimoni, S. Pelucchi, D. Di Luca; Ferrara, Italy 366 P4.01.014 - Beta-amyloidogenic peptides protect against Herpes Simplex Virus-1 (HSV-1) infections Karine Bourgade-Navarro, G. Giroux, C. Bocti, A. Le Page, G. Dupuis, E.H. Frost, T. Fülöp; Sherbrooke, Canada 367 P4.01.015 - HSV-1 infection causes reduced surface expression of MHCII and co-stimulatory molecules on infected DC and suppressed T cell activation in vitro Ramachandramouli Budida, M.V. Stankov, K. Doehner, A. Buch, B. Sodeik, G.M.N. Behrens; Hannover, Germany 368 P4.01.016 - Lethal immune mediated-disease after LCMV infection in STAT1 KO mice requires interferon regulatory factor 7 and is driven by type I interferon Iain L. Campbell, W. Li, M.J. Hofer; Sydney, Australia 369 P4.01.017 - Influenza vaccination leads to dramatic redistribution of lymph node resident dendritic cells into inter-follicular regions M.C. Woodruff, S. Turley, Michael C. Carroll; Boston, United States 370 P4.01.019 - Rapid T cell activation following Epstein-Barr virus transformed lymphoblastoid cell line co-culture with peripheral blood mononuclear cells from cytomegalovirus positive but Epstein-Barr virus naïve children Claudia Carvalho-Queiroz, S. Saghafian-Hedengren, N. Nagy, C. Nilsson, E. Sverremark-Ekström; Stockholm, Sweden 371 P4.01.020 - Seroprevalence against pandemic influenza virus A/H1N1/2009 in pregnant women Arturo Cérbulo-Vázquez, G. Cruz-Cureño, I. Garate-Bosco, C. López Macías, A. Isibasi, L. Arriaga-Pizano, J. Mancilla; Mexico City, Mexico 372 P4.01.021 - Role of CD48 in regulation of T-cell mediated immunity in HTLV-1 infection Chioma E. Chibueze, Y. White, M. Yoshimitsu, K. Uozumi, N. Arima; Kagoshima, Japan 373 P4.01.022 - Identification of Antiviral-related Genes Up-regulated in Response to Bombyx mori Nucleopolyhedrovirus T. Goo, S. Kim, Kwangho Choi, S. Kim, S. Park, S. Kang, E. Yun; Suwon, Korea, Republic of 374 P4.01.024 - Cross-reactive antibodies to swine influenza viruses in adults after vaccination with trivalent inactivated influenza vaccine in Korea Jang-Hoon Choi, N. Lee, K. Shin, C. Kang; Osong-eup, Korea, Republic of 375 P4.01.025 - Pentamers and streptamers for the monitoring of CMV-specific CD8+ T-cell immune reconstitution after allogeneic stem cell transplantation: a comparative analysis Miriam Ciaurriz, N. Ramirez, L. Beloki, C. Mansilla, A. Zabalza, E. Bandres, M. Rodriguez, E. Olavarria; Pamplona, Spain 376 P4.01.026 - Targeted PGE2 inhibition enhances anti-influenza immunity through induction of type I IFN in Macrophages Maziar Divangahi, F. Coulombe, J. Jaworska, M. Verway, F. Tzalepis, G. Kobinger, P. Joubert, J.H. Fritz, Z. Xing, W.S. Powell; Montreal, Canada 181 Posters - August 25 377 P4.01.027 - Serological survey of BTV in Morocco Kamar Drif, O. Fassi Fihri, C. Loutfi, G. Sebbar, M. Moulay Ennaji, M. Elharrak; Rabat, Morocco 378 P4.01.028 - Prevalence of human papillomavirus subtypes in breast cancer in Moroccan woman Amal Elamrani, M. Ennaji, M. Benhassou, M. Attaleb, M. Mzibri, M. Corbex, M. Tomassino, T. Gheit, M. Khyatti; Casablanca, Morocco 379 P4.01.029 - Lung CD8+ T cell impairment during acute viral respiratory infection is associated with a unique gene expression profile John J. Erickson, P. Lu, P. Gilchuk, S. Joyce, Y. Shyr, J.V. Williams; Nashville, United States 380 P4.01.030 - The complement system has a critical role in the inflammatory reaction that follows influenza virus infection Santiago F. Gonzalez, C. Herndon, J. Ortin, M. Carroll; Bellinzona, Switzerland 381 P4.01.031 - Human cytomegalovirus directly supress CD4 T-lymfocyte activation and proliferation Olesja Fornara, J. Odeberg, Z. Khan, G. Stragliotto, I. Peredo, L. Butler, C. Söderberg Nauclér; Stockholm, Sweden 382 P4.01.032 - Narrowing of influenza A virus specific T-cell receptor alpha and beta repertoire with increasing age A. Gil, M.B. Yassai, Y.N. Naumov, Liisa K. Selin; Worcester, United States 383 P4.01.033 - Study of humoral immune response in patients with tick-borne encephalitis against the background of virus circulation Anatoliy P. Godovalov, L.P. Bykova; Perm, Russian Federation 384 P4.01.034 - Some liquorogic features of meningeal form of tick-borne encephalitis Anatoliy P. Godovalov, L.P. Bykova; Perm, Russian Federation 385 P4.01.035 - EBV infection leads to activation of chronic lymphocytic leukemia (CLL) cells and worsen clinical prognosis in CLL patients J. Rolinski, Ewelina Grywalska, A. Bojarska-Junak, P. Grabarczyk; Lublin, Poland 386 P4.01.036 - Activation of type III interferon response by human paramyxovirus infection Maria Guerrero-Plata, R. Banos-Lara, L. Harvey, A. Mendoza; Baton Rouge, United States 387 P4.01.037 - Influenza virus NS1 protein counteracts ZAPS function to evade RIG-I-mediated antiviral defence Sumio Hayakawa, T. Kameyama, T. Yamada, A. Takaoka; Sapporo, Japan 388 P4.01.038 - Virus-associated activation of innate immunity induces rapid disruption of Peyer’s patches in mice Simon Heidegger, D. Anz, N. Stephan, B. Bohn, T. Herbst, K. Eisenächer, C. Hotz, S. Endres, C. Bourquin; Munich, Germany 389 P4.01.039 - Aged-related changes in the immune response to influenza infection Esteban A. Hernandez-Vargas, T. Ebensen, S. Binder, C. Guzman, M. Meyer-Hermann; Braunschweig, Germany 390 P4.01.040 - Myeloid derived supressor cells restrain Natural Killer cell activity in CVB3 myocarditis Lisa M. Holz, M. Sauter, N. Ettischer, R. Kandolf, K. Klingel; Tuebingen, Germany 391 P4.01.041 - Influenza-specific B cell response in the human challenge model for influenza A virus Arthur K.Y. Huang, C. Li, C. Chui, T. Wilkinson, R. Lambkin-Williams, A. Gilbert, J. Oxford, A.J. McMichael, X. Xu; Taoyuan, Taiwan 392 P4.01.042 - Inhibition of monocyte differentiation into dendritic cells by HTLV-I-infected breast milk macrophages Shinichiro Inagaki, M. Takahashi, Y. Fukunaga, H. Takahashi; Tokyo, Japan 393 P4.01.043 - Dengue and other flavi virus specific T cell specific responses in healthy individuals in Sri Lanka Kamal C. Jeewandara, G.N. Malavige, T.N. Adikari, M. Salimi, M.H.J.D. Ariyaratne, M. Peellawate, V. Jayasuriya, G.S. Ogg; Nugegoda, Sri Lanka 394 P4.01.045 - Release of interleukin-1alpha from herpes simplex virus 1 infected keratinocytes provides a functional danger signal K.A. Milora, Liselotte E. Jensen; Philadelphia, United States 395 P4.01.046 - Elevated plasma soluble Sema4D/CD100 level in patients with hemorrhagic fever with renal syndrome: positive correlation with disease severity Boquan Jin, B. Liu, Y. Ma, J. Yi, Z. Xu, Y. Zhang, C. Zhang, R. Zhuang, J. Wang, Y. Zhang; Xi’an, China 396 P4.01.047 - Evaluation of the immune response of live attenuated mumps vaccines (RS-12 strain) produced with different stabilizers in guinea pigs Razieh Kamali Jamil, Z. Sadigh, M. Taqavian, M. Shahkarami, F. Esna-Ashari; Karaj, Iran, Islamic Republic of 182 Posters - August 25 397 P4.01.048 - A NK complex-linked locus restricts the spread of Herpes simplex virus type 1 (HSV-1) in the central nervous system (CNS) of C57BL/6 mice Lorne F. Kastrukoff, A.S. Lau, F. Takei, A.A. Scalzo, F.R. Carbone; Vancouver, Canada 398 P4.01.049 - The importance of cross-strain protective human TCR signatures for universal immunity against influenza S. Valkenburg, S. Quinones Parra, L. Loh, S. Gras, L. Kedzierski, J. Rossjohn, P.C. Doherty, S. Turner, P.G. Thomas, Katherine Kedzierska; Parkville, Australia 399 P4.01.050 - T cell mediated mortality in neonatal mice upon LCMV infection Laurie L. Kenney, E.P. Carter, L.K. Selin; Worcester, United States 400 P4.01.051 - Association between IL-28B(rs12979860) polymorphisms of interferon-λ (IFN- λ) family with Hepatitis C virus infection outcome Rezvan Khajavi, A. Rafiei; Sari, Iran, Islamic Republic of 401 P4.01.052 - Regulatory T cells in persistently virus infected hosts influenced immune responses against superinfection with unrelated viruses J. Duppach, S. Francois, T. Sparwasser, U. Dittmer, Anke R.M. Kraft; Hannover, Germany 402 P4.01.053 - Granzyme B mediated T-cell immunity against small DNA viruses Arun Kumar, A. Kantele, L. Hedman, K. Hedman, R. Franssila; Helsinki, Finland 403 P4.01.054 - TLRs expression dynamics in patients with herpes-associated erythema multiforme due to immunotherapy E.A. Sorokina, N.K. Akhmatova, S. Skhodova, Olga V. Lebedinskaya; Perm, Russian Federation 404 P4.01.055 - Interferon-γ regulates contraction of the influenza-specific CD8 T cell response and limits the size of the memory population N. Prabhu, Debbie C.P. Lee, A.W. Ho, K.H.S. Wong, P.E. Hutchinson, Y. Chua, S. Baalasubramanian, D.M. Kemeny; Singapore, Singapore 405 P4.01.056 - Regulation of inducible expression of syncytin-1 following influenza A/WSN/33 virus infection Fang Li, C. Nellåker, A. Johansson, B. Owe-Larsson, S. Sabunciyan, H. Karlsson; Stockholm, Sweden 406 P4.01.057 - Profile of NAb responses in HIV-1-infected individuals in China and epitope analysis of viral envelope from broad neutralizers C. Ren, S. Liu, Y. Li, H. Yu, J. Wang, Z. Chen, F. Sun, W. Liu, S. Liang, P. Zhong, M. Zhuang, Hong Ling; Harbin, China 407 P4.01.058 - Delivery of human EV71 receptor by adeno-associated virus increase EV71 infection in adult mice Shih-Jen Liu, H. Shiao, A. Chou, S. Lin, I. Chen, P. Chong, M. Tao; Miaoli County, Taiwan 408 P4.01.059 - Double-stranded RNA (dsRNA)-induced IP-10/CXCL-10 production is augmented by Fas activation Caitriona Lyons, R. Moran, A. Houston, E. Brint; Cork, Ireland 409 P4.01.060 - Contribution of Hantaan virus-specific CD4+ T cells to anti-viral T-cell response in humans Ying Ma, B. Yuan, Y. Zhang, Y. Zhang, B. Liu, C. Zhang, R. Zhuang, B. Jin; Xi’an, China 410 P4.01.061 - CD200R1 is required for sustained HSV-1 infection and for HSV-induced and TLR2-dependent response Christopher R. MacKay, E. Kurt-Jones; Worcester, United States 411 P4.01.062 - α-defensin-induced MxA expression in healthy human periodontal tissue Rangsini Mahanonda, N. Sa-Ard-Iam, P. Rerkyen, A. Thitithanyanont, K. Subbalekha, S. Pichyangkul; Bangkok, Thailand 412 P4.01.063 - Immflammation in Influenza A H1N1 pandemic virus Pamela Martinez-Orellana, R. Almansa, B. Bidana, L. Cordoba, J. Martínez, J. Bermejo-Martin, M. Montoya; Barcelona, Spain 413 P4.01.064 - Strategies eliciting cross-reactive CD8+ T cell immunity by increasing cross presentation of nonreplicating viral immunogens Carmela Martire, B. Garulli, G. Di Mario, M.R. Castrucci, V. Barnaba, D. Accapezzato; Rome, Italy 414 P4.01.065 - mTOR-dependent regulation of mucosal CD8 T cell immunity R.T. Sowell, M. Rogozinska, C.E. Nelson, V. Vezys, Amanda L. Marzo; Chicago, United States 415 P4.01.066 - mTOR regulates protection against a lethal H5N1 influenza infection by modulating the antibody response Maureen A. McGargill, R. Keating, T. Hertz, M. Wehenkel, T.L. Harris, B.A. Edwards, J.L. McClaren, S.A. Brown, P.C. Doherty, P. Thomas; Memphis, United States 416 P4.01.067 - Influence of the factors OCT3/4, SOX2, KLF4 or c-Myc on cell transformation promoted by the oncoprotein tax from HTLV-I Gustavo E.A.B. Melo, K.T. Jeang, L. Zane, E.R. Vieira; Diamantina, Brazil 183 Posters - August 25 417 P4.01.069 - Immune deficiency in newborns and infants with cytomegalovirus infections Nushaba O. Mollayeva; Baku, Azerbaijan 418 P4.01.070 - APOBEC3 deaminases induce hypermutation in human papillomavirus 16 viral genomic DNA upon interferon-β stimulation Masamichi Muramatsu, Z. Wang, K. Wakae, K. Kitamura, M. Nakamura, S. Kyo, I. Kukimoto; Kanazawa, Japan 419 P4.01.071 - Rapid method to screen for CMV, EBV, and AdV specific T cells in multiple samples Michaela Niemöller, K. Lange, S. Weber-Lohmann, S. Höher-Peters, M. Assenmacher, A. Richter; Bergisch Gladbach, Germany 420 P4.01.072 - Polyfunctional T cells are generated concurrent with the establishment of immunodominance hierarchy during the evolution of the T cell responses to Epstein-Barr virus Jia Ning, K.H. Chan, A.K.S. Chiang; Hong Kong, China 421 P4.01.073 - Neuroimmunological characterization of children suffering from psychomotor retardation due to Cytomegalovirus infection E. Noris- Garcia, M. Interian, D. Padron, E. Aguero, M. Gonzalez, Giselle Penton Rol; La Havana, Cuba 422 P4.01.074 - Role of the FCGR2A Polymorphism in Susceptibility to Dengue in a Venezuelan Population Violeta Ogando, A. Guadarrama, E.V. Salazar, M.T. Fernandez-Mestre; Caracas, Venezuela, Bolivarian Republic of 423 P4.01.075 - Poly-γ-glutamic acid, a polypeptide secreted by Bacillus sp., induces CD14-dependent type I interferon responses through the TLR4-MD2 complex W. Lee, H. Cho, Jong-Won Oh; Seoul, Korea, Republic of 424 P4.01.076 - Phosphorylation dependent 14-3-3 protein interactions in innate immune response Tiina Öhman, S. Söderholm, P. Hintsanen, E. Välimäki, N. Lietzén, T. Aittokallio, S. Matikainen, T.A. Nyman; Helsinki, Finland 425 P4.01.078 - Expression of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) in the human term placenta A. Jabło ska, P. Suski, M. Studzi ska, J. Kalinka, Edyta Paradowska; Łód , Poland 426 P4.01.079 - Immune response to Apeu virus (orthobunyavirus) infection in murine model Paulo C. Peregrino Ferreira, A.T. Chaves, A. Bozzi, J.G. Oliveira, F.C. Costa, J.R. Santos, O.A. Martins-Filho, E.G. Kroon, R. Correa-Oliveira; Belo Horizonte, Brazil 427 P4.01.080 - Vaccinia and Apeu virus activation of human double-negative T cells stimulated in vitro Paulo C. Peregrino Ferreira, F.N.A. Villani, T.E. Silva, E.G. Kroon, J.G. Oliveira, O.A. Martins-Filho, R. Correa-Oliveira; Belo Horizonte, Brazil 428 P4.01.081 - Mkk4 is not essential for negative selection but is required for optimal T cell activation and function during acute but not chronic infection Simon P. Preston, J.P. Cooney, M. Pellegrini; Melbourne, Australia 429 P4.01.082 - Human APOBEC3 cytidine deaminases: not simply antiviral defense? Ann-Mareen Räthe, T. Kehl, M. Löchelt; Heidelberg, Germany 430 P4.01.083 - An evidence for the pathogenic role for virus-specific T cells in the mouse model of coxsackievirus B3-induced myocarditis A. Gangaplara, C. Massilamany, D. Steffen, A. Pattnaik, S. Huber, Jay Reddy; Lincoln, United States 431 P4.01.084 - Effects of inoculum size on memory T cell inflation during cytomegalovirus infection Anke Redeker, S.P.M. Welten, R. Arens; Leiden, Netherlands 432 P4.01.085 - Investigation of ELISA and PCR for diagnosis of Infectious Mononucleosis R.T.S.S. Roghanian, R.T.S.S. Roghanian, Rasoul T.S.S. Roghanian; Isfahan, Iran, Islamic Republic of 433 P4.01.086 - Virus detection within leucocytes of Atlantic salmon (Salmo salar L.) by flow cytometry Anita Rønneseth, G.T. Haugland, H.I. Wergeland; Bergen, Norway 434 P4.01.087 - Human papillomavirus-associated induction of human β-defensins in cervical intraepithelial lesions Cristina D. Rusanu, I. Iancu, A. Botezatu, I. Huica, G. Anton; Bucharest, Romania 435 P4.01.088 - PD-1 induces anti-viral T cell motility paralysis: the immunological synapse perspective. Catarina Sacristan, M. Cammer, B.H. Zinselmeyer, S. Heydari, D. Nayak, J. Herz, X. Cheng, S.J. Davis, M.L. Dustin, D.B. McGavern; New York, United States 436 P4.01.089 - Immunologic response among adults infected by different HIV-1 Subtypes who on anti-retroviral drugs in Northern Tanzania Elichilia R.P.N. Shao, B.M.R. Nyombi, J.B. Sabuni; Moshi, Tanzania, United Republic of 184 Posters - August 25 437 P4.01.090 - Development of a new generation smallpox vaccines Sergei N. Shchelkunov, R. Maksyutov, I. Kolosova, S. Yakubitskiy, E. Gavrilova, G. Shchelkunova; Koltsovo, Russian Federation 438 P4.01.091 - Plasticity of uterine Natural Killer cells during maternal cytomegalovirus infection N. Jabrane-Ferrat, Johan Siewiera; Toulouse, France 439 P4.01.093 - Severe tuberculosis is associated with a mixed (Th1, Th2, Th17) defective cytokine response to Mycobacterium.tuberculosis antigens in children M. Armand, V. Chhor, A. de Lauzanne, V. Guérin-El Khourouj, B. Pédron, P. Gressens, A. Faye, Ghislaine Sterkers; Paris, France 440 P4.01.095 - Expression profiles of Toll-like receptors 1-10 in human placenta during viral infection Patrycja Suski, J. Kalinka, M. Studzi ska, A. Jabło ska, Z. Le nikowski, E. Paradowska; Łód , Poland 441 P4.01.096 - Blimp-1 as a major transcription factor for the generation and function of cytotoxic CD4 effector T cells (ThCTL) Susan L. Swain, N.B. Marshall, M.D. Brauner, K. Kuang, L. Berg; Worcester, United States 442 P4.01.097 - Chronic exposure to IFNα reduces T helper-dependent antiviral CD8+ T cell responses Kahina Taleb, P. Villefroy, A. Hosmalin, A. Le Bon; Paris, France 443 P4.01.098 - Differential cytokine and chemokine signatures produced by human innate immune cells after in vitro infection with West Nile virus isolates Andrea Teixeira-Carvalho, L.M. Espina-Gomez, C. Chancey, A. Grinev, K. Bernard, L.D. Kramer, M. Rios; Bethesda, United States 444 P4.01.099 - Pro-apoptotic BH3-only proteins Noxa and Bim co-operate to negatively regulate CD8+ T cells during chronic active infection Jesse G. Toe, S.P. Preston, J.P. Cooney, H.W. Scott, G. Ebert, C.C. Allison, M. Pellegrini; Melbourne, Australia 445 P4.01.100 - Differential Responses of Immune Cells to Type I Interferon Contribute to Host Resistance to Viral Infection T. Baranek, T. Vu Manh, Y. Alexandre, M. Maqbool, J. Cabeza, Elena Tomasello, K. Crozat, G. Bessou, M. Dalod; Marseille, France 446 P4.01.102 - CytoDiffTM panel allowing monitoring effectiveness of the highly active antiretroviral therapy on HIV infected patients Vadim E. Tseylikman, I. Reshetnikov, G. Bouvier, S. Kvyatkovskaya, S. Kvyatkovskaya, D. Faye, &. Mirkina, E. Gautherot, &. Shatirko, E. Sukhacheva; Chelyabinsk, Russian Federation 447 P4.01.103 - Universal influenza vaccine requires CD4 T cells for heterosubtypic protection Sophie A. Valkenburg, O.T.W. Li, L.L.M. Poon; Pokfulam, Hong Kong 448 P4.01.104 - BCG restores antiviral immune response in patients with recurrent respiratory papillomatosis by affecting dendritic cell differentiation Evelina Vetskova, T. Avramov, M. Muhtarova, T. Stefanova, M. Nikolova; Sofia, Bulgaria 449 P4.01.105 - The influence of antibodies on the immune response to respiratory syncytial virus infection Marloes Vissers, I. Schreurs, M.I. de Jonge, R. de Groot, G. Ferwerda; Nijmegen, Netherlands 450 P4.01.106 - Lipopolysaccharide stimulation inhibits viral infection of human macrophages with two distinct mechanisms Marloes Vissers, K.R. Short, P.W.M. Hermans, D.A. Diavatopoulos, G. Ferwerda; Nijmegen, Netherlands 451 P4.01.107 - A novel RSV genetic vaccine based on chimpanzee Adenovirus and MVA vectors is safe and highly immunogenic in animal model and fully protects cotton rats and newborn calves from RSV challenge Alessandra Vitelli, A. Pierantoni, S. Capone, S. Colloca, A. Folgori, E. Scarselli, G. Taylor, M. Thom, R. Cortese, A. Nicosia; Rome, Italy 452 P4.01.108 - Molecular characterization of rotavirus detected in diarrhoeic children less than five years of age in Kano State, Nigeria Aminu Wada-Kura, O.S. Olonitola, S. Mijatovic-Rustempasic, M.D. Esona, A.G. Abubakar, M.D. Bowen, M. Aminu; Abuja, Nigeria 453 P4.01.109 - A Critical Role of IL-17 in Modulating B Cell Response During H5N1 Influenza Virus Infection Xiaohui Wang, L. Lu; Hong Kong, China 454 P4.01.110 - Early growth response genes (Egr) -2 and -3 are essential for the activation of naïve B and T cell and primary response against virus infection Ping Wang; London, United Kingdom 455 P4.01.111 - Peripheral blood monocytes in acute and stable copd have impaired responses to respiratory viruses Peter Wark, H.V. See, J. Simpson, P. Hansbro; New Lambton, Australia 185 Posters - August 25 456 P4.01.112 - Distinct immunity between pandemic H1N1 and seasonal H3N2 influenza infections in humans Chi-Chen Wei, L. Wang, P. Huang, K.D. Yang; ChangHua, Taiwan 457 P4.01.113 - Role of host and viral factors in negative antibody response of seronegative occult hepatitis B virus infection Ratna S. Wijaya, S.I. Ie, Y. A, T. Turyadi, K.E. El-Khobar, A.R. Harahap, D.H. Muljono; Tangerang, Indonesia 458 P4.01.114 - Viral dsRNA and ssRNA analogues directly activate mast cells to cysteinyl leukotriene generation and modulate their IgE-dependent releasability Piotr Witczak, K. Wódz, E. B bolewska, A. Słodka, E. Brzezi ska-Błaszczyk; Łód , Poland 459 P4.01.115 - Secondary Streptococcus pnuemoniae infection impairs the immunity to influenza virus by down-regulating the adaptive immune response Yuet Wu, K.H. Chow, P.L. Ho, W. Tu, Y.L. Lau; Hong Kong, Hong Kong 460 P4.01.116 - Irreversibly skewed development of B cells towards terminal stages during HIV-1 infection and resulted in their functional impairment J. Yan, C. Qiu, L. Li, C. Qiu, J. Sun, J. Xu, Xiaoyan Zhang; Shanghai, China 461 P4.01.117 - Immunological pressure by monoclonal antibodies targeting glycoproteins of the 2009 pandemic influenza A(H1N1) virus drives quasi-species with increased virulence in mice Hwajung Yi, M. Lee, C. Kang; Chungcheongbuk-do, Korea, Republic of 462 P4.01.118 - Adaptive Immunity Restricts Replication of Novel Murine Astroviruses Christine C. Yokoyama, J. Loh, G. Zhao, T.S. Stappenbeck, D. Wang, H.V. Huang, H.W. Virgin, L.B. Thackray; Saint Louis, United States 463 P4.01.119 - Hepatitis C virus-infected cells induce down-regulation of natural killer cell activating receptors through modulation of receptor traffic Joo Chun Yoon, D. Choi, J. Park, J. Lee; Seoul, Korea, Republic of 464 P4.01.120 - The roles of Interferon regulatory factor members in virus infection sensitized IDO immunomodulation Ren-In You, S. Lo, C. Yang, M. Dai, T. Chao, Ching-Liang Chu; Hualien, Taiwan 465 P4.01.121 - Immunogenicity of two measles-mumps-rubella vaccines in Iranian pre-school children, a randomized controlled trial Saeed Zarei, M. Jeddi-Tehrani, H. Zeraati, F. Pourheidari, A.A. Ferydonfar, J. Nasernia, B. Tavangar, Y. Vojgani, M.M. Akhondi, F. Shokri; Tehran, Iran, Islamic Republic of 466 P4.01.122 - HCV-specific CD8+ T-cells are abundant in HCV-seronegatives but show private TCR repertoires Shihong Zhang, R.K. Bakshi, P. Fytili, R. Jacobs, M.P. Manns, H. Wedemeyer, A. Kraft, M. Cornberg, V. Schlaphoff; Hannover, Germany 467 P4.01.123 - MAP kinase phosphatase 5 targets IRF3 to regulate type I interferon production in response to influenza infection Yongliang Zhang, S.J. James, H. Teh, H. Takahshi; Singapore, Singapore 468 P4.01.124 - 2009 H1N1 infection primes for strong immunological memory in human nasal-associated lymphoid tissue that offers cross-reactive immunity to H1N1 and avian H5N1 viruses W. Mahallawi, A. Kasbekar, M. McCormick, K. Hoschler, N. Temperton, S.C. Leong, H. Beer, F. Ferrara, P.S. McNamara, Qibo Zhang; Liverpool, United Kingdom 469 P4.01.125 - Impact of vaccination route and chosen adjuvant on immune responses and host-pathogen interplay during influenza infection Vanessa Zurli, M. Taccone, M. Brazzoli, S. Gallorini, C. Galeone, A. Bonci, D. Casini, B. Baudner, S. Bertholet, A. Seubert; Siena, Italy P4.03 HIV PATHOGENESIS AND IMMUNITY Session Time: Sunday, August 25, 13:20 - 15:00 470 P4.03.01 - The MHC class II transactivator CIITA inhibits HIV-1 replication in monocytic cells G. Forlani, E. Vicenzi, S. Ghezzi, G. Poli, Roberto S. Accolla, G. Tosi; Varese, Italy 471 P4.03.02 - Antinuclear antibodies in HIV infected Turkish patients Ilhan Afsar, H.H. Er, A. Sener, S. Kaya; Karabaglar/Izmir, Turkey 472 P4.03.03 - HLA-A68 and HLA-B15 Alleles are Correlated with Poor Immune Response to Highly Active Antiretroviral Therapy among Omani AIDS Patients Ali A. Al-Jabri, M. El-Beeli; Muscat, Oman 473 P4.03.04 - HIV infection is associated with altered monocyte subset proportion and responsiveness to LPS stimulation Thomas A. Angelovich, A. Maisa, J. Zhou, S.M. Crowe, P.M. Smooker, A.C. Hearps, A. Jaworowski; Melbourne, Australia 186 Posters - August 25 474 P4.03.05 - Poor handling of bacterial antigens relate to functionally defective myeloid dendritic cells in advanced stage of HIV infection Sunil K. Arora, M. Sachdeva, A. Sharma; Chandigarh, India 475 P4.03.06 - No association between TNF-α genetic variants and lipodystrophy in a population of HIV-infected patients from South of Spain María J. Bravo, J.D. Colmenero, M. Delgado, F. Orihuela, P. Morata, A. Alonso, A. Caballero, N. Fernández; Málaga, Spain 476 P4.03.07 - Increased immune activation and susceptibility to HIV-1 of CD4+ T cells in children born to HIV-1 infected women Madeleine J. Bunders, J.L. van Hamme, M.H. Jansen, K. Boer, N.A. Kootstra, T.W. Kuijpers; Amsterdam, Netherlands 477 P4.03.08 - Phenotypic and functional characterization of CD4 stem-cell like memory cells in rhesus macaques Emily Cartwright, C. McGary, M. Paiardini, A. Chahroudi, G. Silvestri; Atlanta, United States 478 P4.03.09 - Association of DC-SIGNR genotypes with dendritic cells in HIV-1 infection Omkar Chaudhary, M. Bala, J. Singh, A. Hazarika, R. Kumar, K. Luthra; New Delhi, India 479 P4.03.10 - Systems methodologies for understanding the pathogenesis of HIV infection Valery A. Chereshnev; Yekaterinburg, Russian Federation 480 P4.03.11 - Antiphospholipid antibodies in perinatally HIV infected children Liudmyla Chernyshova, Y. Stepanovskiy, B. Dons’koi, V. Chernyshov; Kiev, Ukraine 481 P4.03.12 - Mother-to-child anti-Nef antibody passage may protect HIV-1 vertically-infected children from AIDS disease Guillermo Corró, S.A. Marino, C.A. Rocco; Buenos Aires, Argentina 482 P4.03.13 - Inflammatory status in residual immunodeficiency under cART in HIV-infected patients Rebeca S. de Pablo-Bernal, E. Ruiz-Mateos, J. Delgado, R. de la Rosa, M. Leal, S. Ferrando-Martinez; Sevilla, Spain 483 P4.03.14 - Evaluation of Monocytes and Natural Killer cells activation, inflammatory parameters in Virologically Suppressed HIV infected Maraviroc treated patients Chiara Dentone, A. Di Biagio, A. De Maria, G. Cenderello, P. Fraccaro, A. Parodi, A. Signori, F. Bozzano, G. Filaci, D. Fenoglio; Genoa, Italy 484 P4.03.15 - Analysis of NKG2D ligand expression and release during HIV-1 infection: implication for NKG2D-mediated immunosurveillance G. Matusali, L. Vassena, E. Giuliani, Margherita Doria; Rome, Italy 485 P4.03.16 - Presence of HIV-1 broadly neutralizing antibodies during pregnancy in relation to mother-to-child transmission blocking Sheron Dzoro, K. Bedi, S. Mpoloka, A. Chaillon, R. Musonda, S. Gaseitsiwe, V. Novitsky, M. Essex, F. Barin, T. Mduluza; Gaborone, Botswana 486 P4.03.17 - A more pro-inflammatory environment is generated in nervous cells cultures in the simultaneous presence of HIV-1 and Toxoplasma gondii, even with lower parasite replication Edwin E. Escobar, M.A. Alfonzo; Caracas, Venezuela, Bolivarian Republic of 487 P4.03.18 - Enhancement of NK polyfunctional cells upon TLR-7/8 activation is dependent of CD62L expression in HIV-1 exposed non-infected individuals Josenilson Feitosa Lima, L. Mara Silva Oliveira, G. Eimi Mitsunari, A. José Silva Duarte, M. Notomi Sato; São Paulo, Brazil 488 P4.03.19 - Diminished immune response of M1 and M2 macrophages derived from HIV+ patients L.J. Galvão-Lima, M.S. Espindola, L.S. Soares, M.C. Cacemiro, F.A. Zambuzi, C. Fontanari, S.K. Haddad, V.R. Bollela, Fabiani G. Frantz; Ribeirao Preto, Brazil 489 P4.03.20 - NetFCM: A tool for Automated Flow Cytometric Data Analysis Juliet Frederiksen, M. Buggert, J. Tauriainen, A. Karlsson, O. Lund; Lyngby, Denmark 490 P4.03.21 - Divergent immunological and virological profile between HCV viremic HIV-1-infected injection drug users and former blood donors in China Wenqing Geng, H. Cui, H. Sun, H. Shang; Shenyang, China 491 P4.03.22 - Immunomodulatory effects of HIV-1 gp120 on human dendritic cells: role of STAT3/IL-6 axis M. Del Cornò, G. Donninelli, B. Varano, A. Masotti, L. Da Sacco, Sandra Gessani; Rome, Italy 492 P4.03.23 - Early appearance of an age-related, activated monocyte phenotype in young HIV+ individuals Anna C. Hearps, T.A. Angelovich, A. Maisa, G.F. Lichtfuss, C. Palmer, A.L. Landay, A. Jaworowski, S.M. Crowe; Melbourne, Australia 187 Posters - August 25 493 P4.03.24 - Lymphocytes TCD4+ and viral load in patient with premiere of aids that receive antirretroviral treatment Dayme D. Hernandez Requejo, J.J. Perez Avila; Habana, Cuba 494 P4.03.25 - Expression of CX3CR1 drives pro-inflammatory M-DC8+ (“slan-DC”) monocyte and NK cell accumulation into HIV-1-infected patient spleens S. Degrelle, C. Dutertre, S. Amraoui, J. Jourdain, K. Schaekel, B. Fabiani, L. Garderet, R. Cheynier, Y. RIchard, Anne Hosmalin; Paris, France 495 P4.03.26 - Change of cellular immunity in patients with HIV infection and tuberculosis Shalala H. Ibrahimova; Baku, Azerbaijan 496 P4.03.27 - Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo Andrea Introini, C. Vanpouille, A. Lisco, J. Grivel, L. Margolis; Bethesda, United States 497 P4.03.28 - Cytokines found to be elevated in HIV elite controllers reduce HIV replication in vitro Evan S. Jacobs, S.M. Keating, K. Anastos, H. Crystal, R.M. Greenblatt, A.L. Landay, E.T. Golub, J.N. Martin, S. Deeks, P.J. Norris; San Francisco, United States 498 P4.03.29 - DRB1*01:01 gene mutation study in the second exon in patients with HIV/AIDS Diana Kasjko, V. Jasinskis, J. Eglite, E. Dobele, L. Kovalchuka, G. Sture, L. Viksna, A. Sochnevs; Riga, Latvia 499 P4.03.30 - Effect of HAART on reconstitution of memory versus naive T cells during tuberculosis treatment in HIV/active pulmonary tuberculosis individuals Sophie N. Kiyingi; Kampala, Uganda 500 P4.03.31 - The Human Leukocyte Antigen-G 3’UTR 14-bp deletion is associated with increased CD4 T-cell recovery during HAART in European HIV-infected women Margit H. Larsen, L.W. Thørner, C. Erikstrup, L.H. Harritshøj, G. Kronborg, C. Pedersen, C.S. Larsen, G. Pedersen, J. Gerstoft, N. Obel; Copenhagen, Denmark 501 P4.03.32 - Incomplete immune recovery of naïve CD4 T-cell subsets after antiretroviral treatment in HIV-1 infection I-Na Lu, F. Ahmad, N.T. Baerlecken, R. Jacobs, R.E. Schmidt, D. Meyer-Olson; Hannover, Germany 502 P4.03.33 - Dissociation of the nuclear pore complex during viral infection Kazuhiko Maeda, S.A. Almofty, S.K. Singh, M.M.A. Eid, M. Shimoda, N. Sakaguchi; Kumamoto City, Japan 503 P4.03.34 - The origin of emerged HIV after terminating anti-retroviral therapy (ART) Jiro Matsumura, M. Shimizu, E. Shinya, S. Oka, H. Takahashi; Tokyo, Japan 504 P4.03.35 - Viral load impact in HIV cellular immune response from children and adolescents Tais N. Mazzola, J. Bernachi, E. Anjos, A. Longhini, R. Lemos, S. Saad, S. Costa, M. Da Silva, M. Vilela; Campinas, Brazil 505 P4.03.36 - CCR5 expression reduces T-tropic HIV-1 strain infection by forming CD4/CXCR4/CCR5 oligomers L. Martínez-Muñoz, R. Barroso, S.Y. Dyrhaug, G. Navarro, B. Vega, P. Lucas, S.F. Soriano, J. Rodríguez-Frade, R. Franco, Mario Mellado; Madrid, Spain 506 P4.03.37 - T-lymphocyte/macrophage activation and HIV production upon toll-like receptor (TLRs) stimulation in naive and HAART-treated HIV+ patients according to CD4 lymphopenia Esther Merlini, C. Tincati, G.M. Bellistri, J. Sanchez-Martinez, G. Ancona, A. d’Arminio Monforte, G. Marchetti; Milan, Italy 507 P4.03.38 - Platelet activation and activation of cell death pathways in platelets isolated from HIV/AIDS patients Emersom C. Mesquita, E.D. Hottz, R.T. Amâncio, A.M. Japiassú, D.M. Medeiros, B.G.J. Grinsztejn, P.T. Bozza, F.A. Bozza; Rio de Janeiro, Brazil 508 P4.03.39 - Differential capacity of CCR5- and CXCR4-dependent HIV-1 strains to replicate in primary cord blood CD4+ T cells. A transcriptome analysis Mohammad Ali Moni, S. Mariani, E. Vicenzi, G. Poli, P. Liò; Cambridge, United Kingdom 509 P4.03.41 - Chemokine and chemokine receptor expression in HIV-infected individuals with tuberculosis on ATT and ART Kaustuv Nayak, L. Hanna, S. Subramanyam, S. Anbalagan, S. Swaminathan; New Delhi, India 510 P4.03.42 - DNA sensing and innate immune activation during HIV infection Sara K. Nissen, J.F. Højen, R.K. Berg, S.R. Paludan, M. Tolstrup, M.R. Jacobsen, T.H. Mogensen; Aarhus N, Denmark 511 P4.03.43 - Characterization of HIV-specific lymphocytes as a tool for patient management Valentina Orlando, S. Meraviglia, E. Lo Presti, P. Di Carlo, N. Caccamo, L. Titone, F. Dieli; Palermo, Italy 512 P4.03.45 - Development of a new multi-epitope HIV-1 tat/env/pol/gag vaccine candidate: a preliminary study on immunogenicity Roghaye Rahimi, M. Ebtekar, N. Arabi, M. Mahdavi; Tehran, Iran, Islamic Republic of 188 Posters - August 25 513 P4.03.46 - Sub-optimal CD4 T-cell recovery in HIV-1 subtype C patients on antiretroviral therapy: A search for predictive biomarkers and baseline characteristics Gaone Retshabile, E.R. Kisanga, S. Gaseitsiwe, S. Moyo, H. Bussmann, J. Makhema, M. Essex, R. Marlink, R. Musonda; Gaborone, Botswana 514 P4.03.47 - CD4+ T cells lacking SAMHD1 expression are highly proliferative in vivo and decrease during HIV-1 infection Nicolas Ruffin, V. Brezar, D. Ayinde, O. Schwartz, J. Lelievre, Y. Levy, N. Seddiki; Créteil, France 515 P4.03.48 - The HIV Tat protein favors the activation of CD8 T cells thus contributing to HIV-related immune dysfunctions Fabio Sforza, F. Nicoli, V. Finessi, E. Gallerani, A. Caputo, R. Gavioli; Ferrara, Italy 516 P4.03.49 - HIV-1 Nef downregulates CD1a lipid-antigen presentation in dendritic cells via hemopoietic cell kinase (HCK) and p21 activated kinase 2 (PAK2) Eiji Shinya, M. Shimizu, A. Owaki, L. Mori, G. De Libero, H. Takahashi; Tokyo, Japan 517 P4.03.50 - Correlation between c-reactive protein and CD4+ cell count in HIV-infected and HIV/PTB co-infected patients at the University of Maiduguri Teaching Hospital (UMTH), Maiduguri, Nigeria Abdulrahman Tahir, H. Yusuph, B. Bakki, Y.B. Jibrin; Bauchi, Nigeria 518 P4.03.51 - Manipulation of rapid apoptosis for HIV-1 gp160-specific murine CD8+ CTLs by free antigenic peptide in vivo Hidemi Takahashi, M. Shimizu, Y. Norose, S. Takaku, M. Takahashi, Y. Nakagawa; Tokyo, Japan 519 P4.03.52 - Immunological, hematological and biochemical parameters are changed in asymptomatic HIV-infected patients, treated or not with antiretroviral drugs Karen I. Tasca, C.C. de Camargo, M. Gatto, M.B. Mendes, L.R. de Souza; Botucatu, Brazil 520 P4.03.53 - Can cytokine profiles in HIV patients be useful in clinical practice? Karen I. Tasca, M. Gatto, C.C. Camargo, S.A. Calvi, A. Sartori, L.R. de Souza; Botucatu, Brazil 521 P4.03.54 - Nef-HIV-1 dimerization domain plays a key role in p22-phox association and ROS modulation Guillermo Teran-Angel, J.C. Valencia-Molina, L. Barboza, D.L. Peterson, L. Berrueta, S. Salmen; Merida, Venezuela, Bolivarian Republic of 522 P4.03.55 - Genital epithelial cells interferon-alpha production is associated with HIV-1 infection in Beninese female commercial sex workers Valérie Thibodeau, A. Labbé, M. Alary, J. Poudrier, M. Roger; Montreal, Canada 523 P4.03.56 - Membrane-binding domain from NEF-HIV-1 increases FOXP3 transcription factor expression on human monocytes Juan C. Valencia-Molina, G. Teran-Angel, L. Barboza, L. Berrueta, D.L. Peterson, S. Salmen; Merida, Venezuela, Bolivarian Republic of 524 P4.03.57 - The role of immunological tolerance in humoral responses to the 2F5 epitope of HIV-1 Guang Yang, T.M. Holl, Y. Liu, T. Nojima, L. Verkoczy, J.L. VandeBerg, D. Kitamura, B. Haynes, G. Kelsoe; Durham, United States 525 P4.03.58 - Differences in the profile of antiviral response in mothers infected by HIV-1 and newborns Nátalli Zanete Pereira, E.C. Cardoso, G.E. Mitsunari, R.M.S.A. Ruocco, M. Zugaib, J.B. Oliveira-Filho, A.J.S. Duarte, M.N. Sato; São Paulo, Brazil P5.03 GENETICS OF AUTOIMMUNITY Session Time: Sunday, August 25, 13:20 - 15:00 526 P5.03.01 - Contribution of Lewis blood group types and their genes to genetic susceptibility and autoimmune response in Grave’s disease Khedhir H. Ali; Baghdad, Iraq 527 P5.03.03 - Association of LGALS3 gene polymorphism and Rheumatoid arthritis in Zahedan, southeast Iran Mahdi Atabaki, M. Hashemi, H. Daneshvar, Z. Zakeri; zahedan, Iran, Islamic Republic of 528 P5.03.04 - Molecular Analysis of Interleukin-17A Gene Polymorphisms in Patients with Multiple Sclerosis Zohreh Babaloo, R. Kh. Yeganeh, E. Sakhinia, M. Farhoodi, B. Baradaran; Tabriz, Iran, Islamic Republic of 529 P5.03.05 - Role of the GULP gene in renalglomerular macrophage phagocytosis in the autoimmune disorder Systemic Lupus Erythromatosus (SLE) model mice MRL/LPR mesangial cells Hirendra N. Banerjee, A. Alikhan, C. Krauss, C. Reilly; Kolkata, India 530 P5.03.06 - HLA DRB1-genotype in families with T1DM patients Margarita N. Boldyreva, L. Zilberman, T. Yankevic, L. Alexeev, I. Dedov; Moscow, Russian Federation 189 Posters - August 25 531 P5.03.07 - Epigenetic regulation of HLA class II genes and their role in autoimmune diseases Marie Cerná, P. Cepek, M. Zajacová, A. Kotrbova-Kozak; Prague, Czech Republic 532 P5.03.08 - Pristane-induced arthritis loci interact with Slc11a1 gene to determine susceptibility in mice selected for high inflammation Marcelo De Franco, M. Correa, A. Borrego, J.R. Jensen, W.H.C. Cabrera, N. Starobinas, O.G. Ribeiro, A. Galvan, T.A. Dragani, O.M. Ibañez; Sao Paulo, Brazil 533 P5.03.09 - Clinical relevance of typing HLA-DR7-DQ2 haplotype in celiac disease Juan Francisco Delgado de la Poza, M. Amengual Guedán, A. Veraguas Imbernon, E. Rodríguez Sánchez, M. De los Santos de Pelegrín, M. Guallarte Alias; Sabadell, Spain 534 P5.03.10 - Association of BANK-1 and Cytokine gene polymorphisms with Type 1 diabetes: A family-based and case-control study F. Zouidi, Mouna Dkhil, H. Fourati, O. Abida, J. Costa, M. Ben Ayed, T. Kammoun, M. Hachicha, C. Penha-Gonçalves, H. Masmoudi; Sfax, Tunisia 535 P5.03.11 - Causes of Multiple Sclerosis: a functional genomics approach Margaret A. Jordan, J. Field, G. Foo, L. Johnson, L. Laverick, M. Gresle, T. Spelman, H. Butzkeuven, A. Baxter; Townsville, Australia 536 P5.03.12 - Significance of single framework mutations for DNA-binding and hydrolyzing activity of antibodies from mice with autoimmune disorders Arina V. Kozyr, A.V. Kolesnikov, G.A. Savchenko, A.E. Khlyntseva, A.G. Bogun, I.G. Shemyakin, A.G. Gabibov; Obolensk, Russian Federation 537 P5.03.13 - CTLA4 +49G allele in combination with HLA-DR3 associates with type 1 diabetes as well as its onset in North Indians Neeraj Kumar, G. Kaur, U. Kanga, N. Tandon, S.C. Zucman, N.K. Mehra; New Delhi, India 538 P5.03.14 - TRIM39R, but not TRIM39B regulates type I interferon Riho Kurata, A. Tajima, T. Yonezawa, H. Inoko; Chiba, Japan 539 P5.03.15 - A “candidate-interactome” analysis of genome-wide association data in multiple sclerosis Rosella Mechelli, R. Umeton, C. Policano, V. Annibali, G. Coarelli, V.A.G. Ricigliano, A. Fornasiero, -. IMSGC WTCCC2, G. Ristori, M. Salvetti; Rome, Italy 540 P5.03.16 - Immunological relations between autoimmune diseases in Thyroid Screening with Vitiligo Vinit Mehrotra, G. Awasthi, A. Hamidy; Dehradun, India 541 P5.03.17 - Alteration of promiscuous gene expression in the thymus is associated to susceptibility to autoimmune type 1 diabetes mellitus in mice Ernna H. Oliveira, C. Collares, C. Macedo, E. Sakamoto-Hojo, E. Donadi, G. Passos; Ribeirão Preto, Brazil 542 P5.03.18 - Analysis of B-cell activating factor (BAFF) gene polymorphisms (-2841 T/C, -2704 T/C, -2701 T/A, -871 C/T) and soluble BAFF levels in primary Sjögren´s syndrome B.A. Treviño-Talavera, C.A. Palafox-Sánchez, J.F. Muñoz-Valle, M. Vázquez-Villamar, R.E. Navarro-Hernández, G. Orozco-Barocio, M. Vázquez-Del Mercado, Edith Oregon-Romero; Guadalajara, Mexico 543 P5.03.19 - Interleukin-10 gene polymorphisms (-1082 A/G, -819 C/T, -592 C/A) in primary Sjögren’s syndrome M. Vázquez-Villamar, Edith Oregon-Romero, D.C. Salazar-Camarena, B.A. Treviño-Talavera, G. Orozco-Barocio, J.F. Muñoz-Valle, Y. Valle, C.A. Palafox-Sánchez; Guadalajara, Mexico 544 P5.03.20 - Association between cytokine genes’ polymorphism and susceptibility to and severity of mixed connective tissue disease (MCTD) Agnieszka Paradowska-Gorycka, A. Felis-Giemza, M. Jurkowska, M. Olesinska; Warsaw, Poland 545 P5.03.21 - Dysfunction of ABIN1 as genetic basis for lupus nephritis D. Caster, E. Korte, K. McLeish, P. Gaffney, I. Adrianto, S. Nanda, P. Cohen, David Powell; Louisville, United States 546 P5.03.22 - Neurotransmitter GABA-A MAY regulate immune system functions as detected by gene networks of peripheral blood TCD4+, TCD8+ and CD14+ cells of recently diagnosed Type 1 Diabetes Mellitus D.M. Rassi, A.F. Evangelista, G. Martelli-Pallomino, J.O. Crispim, I.J. Wastowski, M. Foss-Freitas, M.C. Foss, E.T. Sakamoto-Hojo, G.A. Passos, Eduardo Antonio Donadi; Ribeirao Preto, Brazil 547 P5.03.23 - The PRL -1149 G/T polymorphism is associated with rheumatoid arthritis and anti-CCP antibodies in Mexican population Zyanya Reyes-Castillo, A.L. Pereira-Suárez, C.A. Palafox-Sánchez, E. Oregón-Romero, J.F. Muñoz-Valle; Guadalajara, Jalisco, Mexico 548 P5.03.24 - Combinatorial control of Th17 and Th1 cell function by genetic variation at genes associated with the IL-23 signaling pathway in spondyloarthritis Magda Rybczynska, M. Coffre, M. Roumier, E. Sechet, H. Law, L. Gossec, M. Dougados, E. Bianchi, L. Rogge; Paris, France 190 Posters - August 25 549 P5.03.25 - Increased systemic autoimmunity in men with sex chromosome aneuploidy (47,XXY) reveals a X-chromosome dosage effect Ram R. Singh, R. Okorogu, P. Surampudi, I. Valera, C. Okereke, C. Wang, R. Swerdloff, R. Halder; Los Angeles, United States 550 P5.03.26 - Study of programmed cell death 1 (PDCD1) genepolymorphims in Iranian patients with Ankylosing Spondylitis Narjes Soleimanifar; Tehran, Iran, Islamic Republic of 551 P5.03.27 - Endocrine orgam-specific autoimmunity in myasthenia gravis with thymoma related to defective function of the autoimmune regulator (AIRE) Anette S.B. Wolff, K. Kisand, J. Owe, N. Gilhus, M.M. Erichsen, B.E.V. Oftedal, N. Willcox, E.S. Husebye; Bergen, Norway 552 P5.03.28 - Behçet’s Syndrome in Iranian Azari People Fatemeh Zare Shahneh, B. Baradaran, S. Moradi, F. Hamzavi, B. Bayazi; Tabriz, Iran, Islamic Republic of P5.06 REGULATORY T CELLS IN AUTOIMMUNITY AND ALLERGY Session Time: Sunday, August 25, 13:20 - 15:00 553 P5.06.01 - CD4+ T cells limit their own-pathogenicity by activating regulatory T cells by different mechanisms in different inflammatory conditions Audrey Baeyens, D. Saadoun, F. Billiard, Y. Grinberg-Bleyer, S. Gregoire, E. Piaggio, K. Loser, B.L. Salomon; Paris, France 554 P5.06.02 - Role of Follicular Regulatory T cells in Multiple Sclerosis Tessa Dhaeze, B. Broux, B. Van Wijmeersch, P. Stinissen, N. Hellings; Diepenbeek, Belgium 555 P5.06.03 - Monocytes drive the induction of CD8+FOXP3+ regulatory T cells via the production of membrane TNF-alpha Shawn D.P. Ellis, M.R. Ehrenstein, C.A. Notley; London, United Kingdom 556 P5.06.04 - Diverse T-cell profiles in children with type 1 diabetes and/or celiac disease Maria Faresjö, K. Åkesson, A. Kivling, A. Rydén; Jönköping, Sweden 557 P5.06.05 - + Foxp3 + Treg and its ICOS + Subsets in Patients with Myocardial Infarction Samira Ghorbani; Isfahan, Iran, Islamic Republic of 558 P5.06.06 - Association between T cell immunoglobulin domain and mucin domain-1 gene polymorphisms with Allergic Rhinitis patients Hadi Hassannia, F. Hosseini, S. Abedian; Tehran, Iran, Islamic Republic of 559 P5.06.07 - Glycogen synthase kinase-3 regulates IL-10 production in Th1 cells Elaine V. Hill, T.H.S. Ng, D.C. Wraith; Bristol, United Kingdom 560 P5.06.08 - Enhanced regulatory T cell function and attenuated DSS-induced colitis in the mice deficient with GPx1 and catalase Hyung-ran Kim, H. Kim, J. Seoh; Seoul, Korea, Republic of 561 P5.06.09 - The extrinsic factors blocking regulatory T cell function in the pathogenesis of SLE Hyung-ran Kim, H. Kim, J. Seoh; Seoul, Korea, Republic of 562 P5.06.10 - Targeting PAI-1 signaling results in the enhancement of iTreg and reduction of mortality in a mouse model of septic shock Hong H. Mu, M. Nourian, H. Jiang; Salt Lake City, United States 563 P5.06.11 - General control nonrepressed 2 (GCN2) kinase participation in the remission phase of experimental autoimmune encephalomyelitis (EAE) in mice Heloisa Orsini, L. Pires, J. Maricato, B.A. Castilho, M. Mariano, A.S. Basso; São Paulo, Brazil 564 P5.06.12 - Effect of fetal therapy on T-regulatory cells during development of experimental allergic encephalomyelitis Ievgeniia A. Porozhan, N.N. Babenko, M.V. Ostankov, A.N. Goltsev; Kharkov, Ukraine 565 P5.06.14 - IL-10 and NOx are associated with CD4(+)FoxP3(+) regulatory T-cell subsets in the Systemic Lupus Erythematosus patients Andrea A. Silva, A.L.B. Santos, N.F. Rosário, A.C.A. Pires, C. Gagliardi; Niteroi, Brazil 566 P5.06.15 - Activin-A-induced human regulatory T cells: novel controllers of allergic asthma Sofia Tousa, M. Semitekolou, I. Morianos, A. Banos, M. Kapasa, K. Samitas, M. Gaga, G. Paraskevopoulos, C. Hawrylowicz, G. Xanthou; Athens, Greece 191 Posters - August 25 567 P5.06.16 - Immune regulation in lupus nephritis: role of CD4+CD25high FOXP3+ T regulatory cells and related cytokines (IL-6, IL-10, TGFβ) Konstantinos Tselios, A. Georgiadou, P. Klonizakis, A. Sarantopoulos, I. Gkougkourelas, M. Pantoura, P. Boura; Thessaloniki, Greece 568 P5.06.17 - Intravenous immunoglobulin selectively enhances CD4+CD25+FOXP3+ Treg function in patients Rogier van Gent, A.S.W. Tjon, T. Tha-In, H.J. Metselaar, L.J.W. van der Laan, Z.M.A. Groothuismink, P.A.W. te Boekhorst, M. van Hagen, J. Kwekkeboom; Rotterdam, Netherlands 569 P5.06.18 - Deficient differentiation of Treg cells in a murine model of Sjögren’s syndrome Akiko Yamada, R. Arakaki, M. Kurosawa, T. Kondo, K. Yamada, Y. Kudo, Y. Hayashi, N. Ishimaru; Tokushima, Japan P6.07 CELL-BASED THERAPY Session Time: Sunday, August 25, 13:20 - 15:00 570 P6.07.01 - Repeated intra-muscular injections of allogeneic mesenchymal stem cells (MSC) promote donor-specific T-cell hypo-responsiveness but also induce allo-antibody Senthilkumar Alagesan, M. Creane, T. O’Brien, R. Ceredig, T. Ritter, M.D. Griffin; Galway, Ireland 571 P6.07.02 - Generation of tolerogenic monocyte-derived dendritic cells from patients with primary Sjögren’s syndrome that suppress Ro/La specific T cell responses R. Volchenkov, J.G. Brun, R. Jonsson, Silke Appel; Bergen, Norway 572 P6.07.03 - Mesenchymal stem cells (MSC) modulate the expression of adhesion molecules involved in activated T-lymphocyte extravasation into the central nervous system (CNS): contribution to the therapeutic effect of MSC in inflammatory CNS diseases? Federica Benvenuto, L. Vergani, F. Gualandi, N. Kerlero De Rosbo, A. Uccelli; Genoa, Italy 573 P6.07.04 - Umbilical cord blood T cells cultured with IL-7 in addition to IL-2 exhibit a higher degree of polyfunctionality and superior proliferation potential Sofia Berglund, J. Gertow, I. Magalhaes, J. Mattsson, M. Uhlin; Stockholm, Sweden 574 P6.07.05 - A simple and quick method for isolation of mononuclear cells from peripheral blood and buffy coat Sudhir Bhatia; Duisburg, Germany 575 P6.07.06 - Altered B cell development and fuctions in Adenosine Deaminase deficient patients Immacolata Brigida, A.V. Sauer, F. Ferrua, S. Giannelli, S. Scaramuzza, M.P. Cicalese, M. Casiraghi, E. Traggiai, M. Van der Burg, A. Aiuti; Milan, Italy 576 P6.07.07 - The effector function of antiviral T cells in stem cell donors is strongly impaired by G-CSF mobilization Carola Bunse, S. Borchers, S. Tischer, N. Moraw, C. Figueiredo, U. Köhl, A. Ganser, R. Blasczyk, E. Mischak-Weissinger, B. Eiz-Vesper; Hannover, Germany 577 P6.07.09 - Overexpression of galectin-9 in islets prolongs grafts survival via downregulation of Th1 responses Feng-Cheng Chou, C. Kuo, Y. Wang, H. Sytwu; Taipei, Taiwan 578 P6.07.10 - T and B cell restricted MOG expression through retroviral transduction of bone marrow stem cells mediates protection against EAE induction Jie Y. Chung, Z. Nasa, A. Joglekar, F. Mackay, F. Alderuccio; Melbourne, Australia 579 P6.07.11 - Intrathecal transplantation of neural stem/precursor cells hampers the CNS-confined immune response of experimental autoimmune encephalomyelitis Donatella De Feo, A. Merlini, C. Laterza, B. Elena, F. Ruffini, G. Martino; Milan, Italy 580 P6.07.12 - Exploring the immunogenicity and efficacy of bone marrow-derived allogeneic cell therapy in vivo using a humanised mouse model Gang Feng, S. Menzies, A. Boyers, M. Rigby, A. Gutteridge, H. Fox, V. Owenson, O. Stevens, R. Deans, P. Whiting; Cambridge UK, United Kingdom 581 P6.07.13 - Performance characterization of a novel cell processing sorter: microchip sorting without aerosols in a closed system J. Lee, L. Pietrzyk, E. Rodriguez-Mesa, John Foster; Santa Barbara, United States 582 P6.07.14 - Purifying Tregs with a new closed sorter L. Pietrzyk, J. Dunne, John Foster; Santa Barbara, United States 583 P6.07.15 - Quality controls of Cell-Based therapies: Assessment of conditioned Dendritic Cells phenotypes by Global Gene Expression Profiles Maria Foti, C. Ripamonti, S. Baldassarri, J. Michalek; Milan, Italy 192 Posters - August 25 584 P6.07.16 - Improved monitoring and generation of HAdV-specific T cells by a newly identified A*02 MHC class I multimer and short-term in vitro expansion René Geyeregger; Vienna, Austria 585 P6.07.17 - Effect of myeloid-derived suppressor cells on dendritic cells maturation and function Najmeh Khosravianfar, A. Namdar, M. Hafezi, A. Razavi, J. Hadjati; Tehran, Iran, Islamic Republic of 586 P6.07.18 - Cloning of human antigen-specific TCRs can confer the candidates for cancer gene therapy Eiji Kobayashi, E. Mizukoshi, H. Kishi, H. Hamana, T. Nagai, T. Ozawa, H. Nakagawa, A. Jin, S. Kaneko, A. Muraguchi; Toyama-shi, Japan 587 P6.07.19 - A novel methodology of immune regulation using pluripotent stem cells H. Kudo, H. Sasaki, H. Wada, S. Kojo, T. Chikaraishi, Ken-ichiro Seino; Kawasaki Kanagawa, Japan 588 P6.07.20 - The application of in vitro expanded CD4 Th1 cells in adoptive cell therapies Kunyu Li, F. Ronchese, M. Thorn, C. Jackson, S. Young; Dunedin, New Zealand 589 P6.07.21 - Chondrogenic differentiation of mesenchymal stem cells alters cellular immunogenicity in vitro and in vivo A.E. Ryan, Paul Lohan, L. O’Flynn, O. Treacy, C. Coleman, G. Shaw, M. Murphy, R. Ceredig, M.D. Griffin, T. Ritter; Galway, Ireland 590 P6.07.22 - Migration of human mesenchymal stem cells towards inflammatory lesions after transfection with CD29 specific siRNA Laura Marusciac, C. Panaitescu, F. Bojin, V. Paunescu; Timisoara, Romania 591 P6.07.23 - Treatment with EBV-Cytotoxic T-Lymphocytes of pediatric liver transplant recipients affected by EBV-related Post-transplantation lymphoproliferative disease in early phase Monica Miele, M. Sciveres, M. Di Bella, S. Riva, G. Amico, R. Liotta, A. Sonzogni, P. Grossi, P. Conaldi; Palermo, Italy 592 P6.07.24 - Immune system modulation during cytokine induced killer cells adoptive therapy in hematologic patients S. Coin, I. Cavattoni, V. Artusi, A. Pievani, I. Pusceddu, E. Tagliafico, S. Cortelazzo, A. Rambaldi, M. Introna, Vladia Monsurro; Verona, Italy 593 P6.07.25 - Toxicity evaluation of CD44v6-specific T cells in a xenograft model that fully recapitulates human hematopoietic development Margherita Norelli, M. Casucci, B. Camisa, L. Falcone, G. Oliveira, A. Saudemont, C. Bordignon, F. Ciceri, C. Bonini, A. Bondanza; Milan, Italy 594 P6.07.26 - TLR7/8 Ligand Is Necessary to Generate Potent Blast-Derived Dendritic Cells in Acute Myeloid Leukemia Maryam Nourizadeh, F. Masoumi, A. Memarian, K. Alimoghaddam, S. Moazzeni, J. Hadjati; Tehran, Iran, Islamic Republic of 595 P6.07.27 - Mannose-α(1→2)-Mannose derivative for dendritic cell targeted delivery Juan S. Pappalardo, T.S. Levchenko, S. Salmaso, C.A. Langellotti, M. Vermeulen, M. Toniutti, T. Musacchio, V.P. Torchilin; Hurlingham, BA, Argentina 596 P6.07.28 - Therapeutic effect of bone marrow-derived clonal mesenchymal stem cells in DSS-induced colitis model J. Park, J. Kim, T. Yi, S. Song, Seok Hee Park; Suwoan, Korea, Republic of 597 P6.07.29 - Update on IPEX syndrome: new diagnostic biomarkers and therapeutic perspectives Laura Passerini, F. Barzaghi, E. Rossi Mel, C. Sartirana, V. Lampasona, E. Bosi, G. Fousteri, L. Naldini, M.G. Roncarolo, R. Bacchetta; Milan, Italy 598 P6.07.30 - Investigation of mouse bone marrow Lin¯ cells regenerative properties in vitro and in vivo Giedre Ramanauskaite, D. Zalalyte, A. Vaitkuviene, V. Kaseta, G. Biziuleviciene; Vilnius, Lithuania 599 P6.07.31 - Promotion of corneal graft survival by donor bone marrow derived dendritic cells is mediated by creating an intragraft immunoregulatory milieu L. O’Flynn, O. Treacy, A.E. Ryan, M. Morcos, L. Joshi, J. Gerlach, M. Cregg, M. Nosov, Thomas Ritter; Galway, Ireland 600 P6.07.32 - Ex vivo generation and expansion of polyclonal human Treg E. Candia, C. Covian, F. Rodriguez, J. Morales, Mario Rosemblatt, J. Fierro; Santiago, Chile 601 P6.07.33 - Generation of highly effective and stable murine alloreactive Tregs by combined anti-CD4 mAb, TGF-β and RA treatment Ulrike Schliesser, M. Chopra, A. Beilhack, S. Vogel, J. Schumann, K. Wood, H. Volk, B. Sawitzki; Berlin, Germany 602 P6.07.34 - Generation and Characterization of WT1-specific T cells derived from healthy donors for adoptive tumor therapy S. Schmied, Anne Richter, M. Assenmacher; Bergisch-Gladbach, Germany 603 P6.07.35 - Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction Michiko Shimoda, A. Bolduc, M. Takezaki, Y. Ametani, A.L. Mellor, M. Kamanaka, R.A. Flavell, T. Tsubata, P.A. Koni; Augusta, United States 193 Posters - August 25 604 P6.07.36 - Cell therapy of cancer with alloreactive intentionally mismatched IL-2 activated donor lymphocytes targeting anti-cancer killer NK & T cells using monoclonal and bispecific antibodies Shimon Slavin, C. Brodie; Tel Aviv, Israel 605 P6.07.37 - Distribution of the lymphoid cells of various functional activity after transplantation Anastasia O. Solovieva, A.F. Poveshchenko, K.E. Zubareva, O.V. Povesh henko, V.I. Konenkov; Novosibirsk, Russian Federation 606 P6.07.38 - Tumor associated fibroblasts are endowed with increased ability to support tumor development Marius Toma, R.A. Lazarovicz, O. Gavriliuc, C.A. Tatu, A. Gruia, C. Tatu, G. Tanasie, C. Panaitescu, F. Bojin, V. Paunescu; Timisoara, Romania 607 P6.07.39 - Mesenchymal stromal cell therapy prolongs corneal allograft survival in rats Oliver Treacy, L. O’Flynn, A. Ryan, M. Morcos, M. Wilk, S. Schu, M. Cregg, M. Griffin, M. Nosov, T. Ritter; Galway, Ireland 608 P6.07.40 - TLR5 signaling enhances the proliferation of human allogeneic CD40-activated-B-cell-induced regulatory CD4 T cells P. Chan, J. Zheng, Y. Liu, Z. Xiang, Wenwei Tu; Hong Kong, Hong Kong 609 P6.07.41 - Adoptive T cell therapy in patients with prostate cancer Katerina Vavrova, K. Zurkova, R. Horvath, J. Bartunkova; Prague, Czech Republic 610 P6.07.42 - Changes in T lymphocyte subsets accompany the clinical response to Mesenchymal Stem Cell (MSC) therapy - first experience in irradiation-induced colitis Jan Voswinkel, J. Lataillade, S. Francois, M. Mohty, N. Gorin, M. Benderitter, A. Chapel; Paris, France 611 P6.07.43 - Genetically modified T cells expressing an affinity enhanced NYESO-1 T Cell Receptor in cancer therapy Daniel D. Williams, A.P. Rapoport, E.A. Stadtmauer, G.K. Binder-Scholl, J.E. Brewer, A.D. Bennett, M. Kalos, B.L. Levine, C.H. June, B.K. Jakobsen; Abingdon, United Kingdom 612 P6.07.44 - Exploring leukemia- and virus-reactive CD8+ T lymphocytes with stem-cell-like and central memory properties for effective immunotherapy in humanized mice Yan Xu, A. Mades, S.A. Khan, M. Theobald, U.F. Hartwig; Mainz, Germany 613 P6.07.45 - Intrapancreatic transplantation of allogeneic mesenchymal stromal cells (MSCs) decreases blood glucose levels in experimental type 1 diabetes Juliana N.U. Yaochite, L.S. Neto, C. Caliári-Oliveira, M.M. da Matta, K.C. Malmegrin, C.C.B.O. Menezes, D.T. Covas, J.C. Voltarelli, E.A. Donadi; Ribeirão Preto, Brazil 614 P6.07.46 - Generation of gene engineered mesenchymal stem cells and its efficacy against human breast cancer Fei Ling Yap, S. Cheong, R. Ammu, C. Leong; Bukit Jalil, Kuala Lumpur, Malaysia 615 P6.07.47 - Endothelial cells: new targets for MSCs-mediated immunomodulation in mouse Lucia Zanotti, C. Soldani, C. Ploia, F. Moalli, E. Dander, G. D’Amico, A. Sarukhan, A. Viola; Rozzano, Milan, Italy 616 P6.07.48 - Treatment of autoimmune hepatitis by inhibiting CD8+T cells using hepatic stroma-induced regulatory DCs Q. Wang, D. Chen, H. He, H. Tang, W. Song, Minghui Zhang; Beijing, China 617 P6.07.49 - Spatial distribution of transplanted bone marrow-derived mesenchymal stem cells in recipient’s organs in the B16 melanoma model Kristina E. Zubareva, A.O. Solovieva, A.F. Povesh henko, O.B. Gritsyk, E.A. Nechaeva, V.I. Konenkov; Novosibirsk, Russian Federation P6.08 STEM CELLS IN IMMUNITY Session Time: Sunday, August 25, 13:20 - 15:00 618 P6.08.01 - Comparison of immunoregulatory properties of stem cells from human exfoliated deciduous teeth and bone marrow-derived mesenchymal stem cells Khadijeh-minoo Adib, R. Alipour, B. Hashemi Beni; Isfahan, Iran, Islamic Republic of 619 P6.08.02 - Production and characterization of murine monoclonal antibodies against human synthetic peptide of CD34 Leili Aghebati Maleki, J. Majidi, B. Baradaran, J. Abdolalizadeh, A. Movassaghpour; Tabriz, Iran, Islamic Republic of 620 P6.08.03 - The effect of TNF-α in differential gene expression pattern of CXCR4 on human marrow-derived mesenchymal stem cells Maryam Banoo Ayatollahi, R. Ziaei, R. Yaghobi, Z. Sahraeian, B. Geramizadeh; Shiraz, Iran, Islamic Republic of 621 P6.08.04 - Association between T Reg marker polymorphism and tuberculosis Elham Beiranvand, S. Abediankenari, B. Beiranvand; Tehran, Iran, Islamic Republic of 194 Posters - August 25 622 P6.08.05 - Developmental endothelial locus-1 (Del-1) is a negative regulator of GCSF-dependent hematopoietic stem cell mobilization Lan-Sun Chen, I. Mitroulis, N. Mende, G. Siegert, C. Waskow, G. Hajishengallis, T. Chavakis; Dresden, Germany 623 P6.08.06 - Differential efficacy of human mesenchymal stem cells on disease in murine lupus based on source of origin E.L. Collins, F. Gu, O. Naga, Gary Gilkeson; Charleston, United States 624 P6.08.07 - LT-beta receptor signaling promotes progression of chronic myeloid leukemia in mice Sabine Hoepner, C. Riether, C. Schürch, A.F. Ochsenbein; University of Bern, Switzerland 625 P6.08.08 - In vivo imaging approach for continuous monitoring of transplanted cells Zaruhi Karabekian, A. Popratiloff, N. Sarvazyan; Washington, United States 626 P6.08.09 - Preparation of a high affinity monoclonal antibody against morphine showing no cross reactivity with heroin Susan Kashanian; Tehran, Iran, Islamic Republic of 627 P6.08.10 - Recombinant human Cyclophilin A supports differentiation of granulocytes Ludmila M. Khromykh, N.L. Kulikova, L.Y. Grivtsova, M.A. Frenkel, N.N. . Tupitsyn, A.A. Kalinina, D.B. Kazansky; Moscow, Russian Federation 628 P6.08.11 - Susceptibility of human cardiac progenitor cells to natural killer cell lysis Laura Lauden, W. Boukouaci, N. Dam, N. Jabrane-Ferrat, D. Charron, R. Tamouza, R. Al-Daccak; Paris, France 629 P6.08.12 - Properties of TiCaPCON-based nanostructured coating as bioimplant constituent A.N. Kopilov, N.Y. Anisimova, Olga V. Lebedinskaya, D.V. Shtansky, M.V. Kiselevsky; Perm, Russian Federation 630 P6.08.13 - Mass-production and characterization of anti-human CD34 monoclonal antibody in peritoneum of BALB/c mice Jafar Majidi, B. Baradaran, l. Aghebati Maleki, J. Abdolalizadeh, A. Movassaghpour; Tabriz, Iran, Islamic Republic of 631 P6.08.14 - Cell Cycle Analysis of Human Colorectal Cancer Stem Cells Reveals their Quiescent Nature Hamid Reza R. Mirzaei, H. Mirzaei, J. Jalili, M. Eghbali, N. Bagherpour; Tehran, Iran, Islamic Republic of 632 P6.08.15 - NF-kB rela-deficient macrophages fail to support bone formation and maintain the microenvironment for hematopoiesis after X-ray irradiation and HSC transplanatation Setsuko Mise-Omata, T. Fukazawa, Y. Obata, T.S. Doi; Tsukuba, Japan 633 P6.08.16 - The effect of the Immunomodulatory functions of adipose derived mesenchymal stem cells on the expression of major transcription factors in CD4 T cell subsets Adel Mohammadzadeh, A. Pourfatolah, M. Soleymani, S. Moradi; Tehran, Iran, Islamic Republic of 634 P6.08.17 - The effect of DiD on the immunosuppressive function and differentiation potency of Mesenchymal stem cells Maryam S. Mohtasebi, F. Nasri, E. Kamali Sarvestani; Shiraz, Iran, Islamic Republic of 635 P6.08.18 - Human mesenchymal stem cells modulation of alveolar macrophage polarization in vivo and in vitro A.D. Krasnodembskaya, Thomas Morrison, D. McAuley, M.A. Matthay; Belfast, United Kingdom 636 P6.08.19 - The characteristic of minor cell populations in multiple sclerosis patients after cell therapy Darya Nizheharodava, A. Borisov, E. Nazarova, E. Rudakovskaya, M. Zafranskaya; Minsk, Belarus 637 P6.08.20 - Immunoregulatory activity of Decidual/Endometrial Stromal Cells in humans Carolina Reyes-Perdomo, K. Torres, M. López, P. Silva, E. García-Olivares, O. Blanco Muñoz; Floridablanca, Colombia 638 P6.08.21 - Adipose Derived Stem Cells Isolated from Omentum: a Novel Source of Chemokines for Ovarian Cancer Growth Somayeh Rezaeifard, M. Razmkhah, M. Robati, M. Momtahan, A. Ghaderi; Shiraz, Iran, Islamic Republic of 639 P6.08.22 - Isolation and Characterization of Mesanchaymal Stem Cells from Mouse Decidua Bizhan Sadighimoghadam, S. Moazzeni; Tehran, Iran, Islamic Republic of 640 P6.08.23 - The role of p15Paf oncogene in hematopoiesis Miloje Savic, L.K. Denzin; New Brunswick, United States 641 P6.08.24 - Cytotoxic CD8+ T cells regulate myelopoiesis by cytokine signals to bone marrow stromal cells Christian Schürch, C. Riether, A.F. Ochsenbein; Bern, Switzerland 642 P6.08.25 - Large zinc finger transcrition factor Schnurri-3 functions in the osteochondroprogenitor cell to regulate bone mass Anju Singh, C. Lester, L.H. Glimcher, D. Jones; Rockville, United States 195 Posters - August 25 P7.02 Systems and theoretical immunology Session Time: Sunday, August 25, 13:20 - 15:00 643 P7.02.01 - Emergence of tissue-level NF-kappaB dynamics during inflammation Christopher R. Boddington, J. Bagnall, L. Schmidt, D.G. Spiller, D.A. Jackson, M.R.H. White, P. Paszek; Manchester, United Kingdom 644 P7.02.02 - Cytokines prophyle in Gaucher disease type I patients with bone metabolic changes Alexandra M. Craciun, P. Grigorescu-Sido, A. Zimmermann; Cluj-Napoca, Romania 645 P7.02.03 - Clostridium difficile infected human signaling pathways: An integrated model Rajat K. De, N. Tomar; Kolkata, India 646 P7.02.04 - Systems Biology Approaches for Predicting and Controlling the Reactivity of Tumor Infiltrating Lymphocytes Moran Hod-Marco, K. Oved, M. Besser, Y. Reiter; Haifa, Israel 647 P7.02.05 - Utilizing next-generation sequencing of the humoral repertoire for monoclonal antibody discovery Tarik A. Khan, A. Mirsky, S.T. Reddy; Basel, Switzerland 648 P7.02.06 - Therapeutic Potential of Inhibition of Complement Activity for Alleviating Degenerative Eye Diseases K. Valter, D. Garnett, J. Zhou, Girish J. Kotwal; Camps, Saint Kitts and Nevis 649 P7.02.07 - Hgshs Nisha Patel; Manchester, United Kingdom 650 P7.02.08 - A new model for estimation of cell proliferation dynamics using Carboxyfluorescein succinimidyl ester (CFSE) data Cristina Peligero, J.M. Argilaguet, W.C. Thompson, H.T. Banks, A. Meyerhans; Barcelona, Spain 651 P7.02.09 - High-throughput antibody repertoire analysis in S. pneumoniae immunized mice U. Haessler, M. Tamborrini, S. Cook, G. Pluschke, Sai T. Reddy; Basel, Switzerland 652 P7.02.10 - Development of a bioinformatic framework for the study of high-throughput antibody repertoire data S. Cook, V. Greiff, A. Mirsky, Sai T. Reddy; Basel, Switzerland 653 P7.02.11 - Heterogenous differentiation patterns in individual CD8+ T lymphocytes Jan C. Rohr, C. Gerlach, L. Perie, N. van Rooij, J.W.J. van Heijst, A. Velds, J. Urbanus, S.H. Naik, J.B. Beltman, H. Jacobs, R. de Boer, T.N.M. Schumacher; Amsterdam, Netherlands 654 P7.02.12 - Thorough characterization of TCR-pMHC binding free energy estimated by string model and Miyazawa-Jernigan matrix Hiromichi Tsurui, S. Hirose; Tokyo, Japan P7.03 STRUCTURAL BIOLOGY IN IMMUNOLOGY Session Time: Sunday, August 25, 13:20 - 15:00 655 P7.03.01 - Polyclonal T-cell Receptors recognise an unusually long tumour antigenic peptide complexed to HLA-B7 Kok-Fei Chan, S. Gras, L. Nielsen, J. McCluskey, J. Rossjohn, W. Chen; Melbourne, Australia 656 P7.03.02 - Use of The Alcoholic Extract of Alfalfa Root Instead of SLO for ASO Diagnostic Test Hamid Chegni, M. Oshaghi, B. Gharegozlou, B. Gharegozlou, B. Gharegozlou; Mashhad, Iran, Islamic Republic of 657 P7.03.03 - Mapping the N- and O-glycome of mouse Peyer’s patches Chu-Wen Cheng, S. Yu, K. Khoo; Taipei, Taiwan 658 P7.03.04 - Disintegrin-like molecule isolated from snake venom induces endothelial cell migration and inhibits adhesion on extracellular matrix components I.C. Lima, J.C. Silva-Santos, M.S. Della-Casa, I.L. Santos, A. Moura-da-Silva, Patricia B. Clissa; São Paulo, Brazil 659 P7.03.05 - Pathological Characteristic of Experimental Colorectal Cancer Model in Three Rat Strains Shouzhi Gu, Z. Liu; Hamamatsu, Japan 660 P7.03.06 - Ubiquitin ligase MARCH I involves peptide discrimination for MHC II complex Yuko Kozono, R. Tanizawa, Y.C. Sasaki, S. Ishido, O. Kanagawa, H. Kozono; Noda, Japan 661 P7.03.07 - Structural analysis of the class II HLA molecule, DP5, in complex with the Cry j 1 antigen of Japanese cedar pollen Seisuke Kusano, M. Shirouzu, K. Yamamoto, T. Sasazuki, S. Yokoyama; Yokohama-city, Kanagawa, Japan 196 Posters - August 25 662 P7.03.08 - Structures of the Pore-Forming Toxin Monalysin solved by X-ray crystallography and electron microscopy Philippe Leone, C. Bebeacua, C. Kellenberger, O. Opota, B. Lemaitre, A. Roussel; Marseille, France 663 P7.03.09 - Homology modeling of the extracellular region of the B cell protein CD19 Mark Maloney, N. Nordgren, W. Nasir, P. Nyholm; Atlanta, United States 664 P7.03.10 - Assessing changes expression and presentation of NKG2D under the influence of serum factors in breast cancer patients Reyhaneh Roshani, a. khodadadi, m. Ghaforian Borujerdnia, a. Talezadeh; ahvaz, Iran, Islamic Republic of 665 P7.03.11 - How T cells engage an EBV-associated cancer epitope Andrea J.A. Schauenburg, J.J. Miles, E. Gostick, D.K. Cole, L. Wooldridge, S.R. Burrows, P.J. Rizkallah, A.K. Sewell, D. Prize; Cardiff, United Kingdom 666 P7.03.12 - Human milk immunoglobulins contain various combinations of antigen-binding sites resulting in binding polyspecificity and catalytic polyreactivity Sergey Sedyh, V. Buneva, G. Nevinsky; Novosibirsk, Russian Federation 667 P7.03.13 - Synergistic inhibition of Her2 overexpressing tumor cells by a combination of anti Her2 monoclonal antibodies Fathollah Tahmasebi; Tehran, Iran, Islamic Republic of 668 P7.03.14 - Nicotinic receptors in nervous and immune systems:identification and functional roles Victor I. Tsetlin, I.V. Shelukhina, I.E. Kasheverov, Y.N. Utkin, M.V. Skok; Moscow, Russian Federation 669 P7.03.15 - Rules that govern high TCR-CD3 cell surface expression Marleen M. van Loenen, R. de Boer, R.S. Hagedoorn, E.H.M. van Egmond, M. Griffioen, J. Falkenburg, M.H.M. Heemskerk; Leiden, Netherlands 197 Posters - August 26 Panel N° P1.04 NKT CELLS Session Time: Monday, August 26, 13:20 - 15:00 001 P1.04.01 - CD2/CD3/CD28 stimulation augments Granzyme B-dependent tumor clearance of Ph+ B-Acute Lymphoblastic Leukemia by ex-vivo expanded human iNKT cells Claudia A. Alves de Araujo, W. Luszczek, C. Calabrese, G. Neale, A. Seth, A. Pillai; Memphis, United States 002 P1.04.02 - Interaction between iNKT and B-1 cells after P.acnes adjuvant stimulus Liane Butin, M. Gambero, M.E. Ishimura, D. Teixeira, A.C. Keller, I.M. Longo-Maugeri; São Paulo, Brazil 003 P1.04.03 - Phenotypic and functional dynamics of invariant Natural Killer T (CD3+6B11+iNKT) cells in patients with tobacco-related oral carcinoma A.K. Singh, N.K. Shukla, Satya N. Das; New Delhi, India 004 P1.04.04 - Role of excessive thymic differentiation of RORgt+NKT17 cells in the pathogenesis of autoimmune diabetes Caterina Di Pietro, A. Rezzonico, M. Fedeli, G. Casorati, M. Falcone; Milan, Italy 005 P1.04.05 - Interleukin-7 Receptor α-dependent thymopoiesis regulates thymic invariant natural killer T cell retention Michael B. Drennan, F. Pattyn, S. Govindarajan, K. De Wilde, S. Schlenner, C. Ware, S. Nedospasov, H. Rodewald, D. Elewaut; Ghent, Belgium 006 P1.04.06 - Difluoro substituted CD1d ligands as optimal adjuvants for the priming of multifunctional CD4 T cells Yifang Gao, B. Linclau, S. Gadola, T. Elliott, A. Williams; Southampton, United Kingdom 007 P1.04.07 - Dynamics of iNKT cell-mediated provision of B cell help for antibody production Yasmeen G. Ghnewa, G.S. Zeng, V.G. Lyons, D.G. Doherty; Dublin, Ireland 008 P1.04.08 - iNKT cells can promote differentiation of B cells into cells with regulatory B cell phenotypes Yasmeen G. Ghnewa, G.S. Zeng, V.P. O’Reilly, D.G. Doherty; Dublin, Ireland 009 P1.04.09 - Effective stimulation of invariant natural killer T cells by oligomannose-coated liposomes Mariko Ishii, N. Kokima; Hiratsuka, Japan 010 P1.04.10 - Sterol carrier protein 2 is required for the maturation of iNKT cells and their stimulation by endogenous lipids Lucia Mori, F. Facciotti, G.S. Ramanjaneyulu, R.B. Chan, M.R. Wenk, U. Seedorf, G. De Libero; Singapore, Singapore 011 P1.04.11 - Octaarginine-modified liposomes enhance α-galactosylceramide based antitumor therapy Takashi Nakamura, D. Yamazaki, J. Yamauchi, H. Harashima; Sapporo, Japan 012 P1.04.12 - Roles of NKT cells in human gastric cancer Carolina H. Ribeiro, F. Cristi, G. Pérez, K. Kramm, M. Bustamante, F. Gálvez, M. Garrido-Tapia, C.J. Hernández, J.C. Aguillón, M.C. Molina; Santiago, Chile 013 P1.04.13 - CD1d-restricted invariant natural killer T (iNKT) cells mediate airway inflammation through IL-25 and IL-18 Hiroshi Watarai; Yokohama, Japan 014 P1.04.14 - Signal control of iNKT development and effector lineage differentiation Xiaoping Zhong, S. Wang, J. Shin, J. Wu; Durham, United States P1.09 DENDRITIC CELL DIFFERENTIATION AND FUNCTION Session Time: Monday, August 26, 13:20 - 15:00 015 P1.09.01 - House dust mite-sensitized myeloid dendritic cells induce reduction of allergen-specific murine airway inflammation Luciana Aragão-França, F. Costa, D. Athanazio, N. Alcântara Neves, L. Pontes de Carvalho; Salvador, Brazil 016 P1.09.02 - E-cadherin contribution for Langerhans cell differentiation Hideko Azuma, N. Mayumi, E. Watanabe, Y. Norose, E. Watari, S. Kawahara, T.B.H. Geijtenbeek, H. Takahashi; Tokyo, Japan 017 P1.09.03 - Novel inducible immortalized dendritic cell line with entire properties of primary cells Joanna Bandola, C. Richter, S. Thieme, M. Laugsch, K. Anastassiadis, S. Brenner; Dresden, Germany 018 P1.09.04 - Age-associated shift in rat dendritic cell T-helper polarizing capacity Biljana Bufan, Z. Stojic -Vukanic , N. Arsenovic -Ranin, D. Kosec, I. Pilipovic, M. Perisic , J. Ðikic , G. Leposavic ; Belgrade, Serbia 198 Posters - August 26 019 P1.09.05 - Junctional Adhesion Molecules and Dendritic Cell Migration S. Roh, Se Eun Byeon, C. Yoon, Y. Bae; Suwon, Gyeonggi-do, Korea, Republic of 020 P1.09.06 - CD300 molecules as regulators of dendritic cell responses Georgina J. Clark, R. Gasiorowski, P. Fromm, D.N.J. Hart; Sydney, Australia 021 P1.09.07 - Human monocyte-derived dendritic cells required direct contact with natural killer cells to induce a Th1 profile of response Maria A. Clavijo Salomón, R.N. Ramos, G.G. Romagnoli, B. Zelante, J.A.M. Barbuto; Sao Paulo, Brazil 022 P1.09.08 - Cytokine production by human dendritic cells treated with Brazilian propolis Bruno J. Conti, K.B. Santiago, E.O. Cardoso, J.M. Sforcin; Botucatu, Brazil 023 P1.09.11 - CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice Marco Di Gioia, I. Zanoni, R. Ostuni, S. Barresi, A. Broggi, B. Costa, R. Marzi, F. Granucci; Milan, Italy 024 P1.09.12 - Role of the Hypoxia-Inducible Factor-1alpha and Akt on hypoxia-induced migratory program in dendritic cells Irene Filippi, C. Aldinucci, A. Pucci, S. Sozzani, F. Carraro, A. Naldini; Siena, Italy 025 P1.09.13 - Ceramide formation is involved in Lactobacillus acidophilus-induced IFN-β response in dendritic cell Eva Fuglsang, L. Henningsen, H. Frøkiær; Copenhagen, Denmark 026 P1.09.15 - T300A variant of autophagy ATG16L1 gene is associated with decreased antigen sampling and processing by dendritic cells in paediatric Crohn’s disease C. Strisciuglio, E. Miele, M.E. Wildenberg, A. Camarca, M. Barone, A. Staiano, R. Troncone, Carmen Gianfrani; Avellino, Italy 027 P1.09.16 - CD137 ligand generated dendritic cells are more potent than classical dendritic cells in inducing an antigen-specific T cell response Zulkarnain Harfuddin; Singapore, Singapore 028 P1.09.17 - Inflammation in the periphery and dendritic cell progenitors in the bone marrow Prue H. Hart, R.L.X. Ng, N.M. Scott, D.H. Strickland; Perth, Australia 029 P1.09.18 - Immune dysregulation in sickle cell disease Borys Hrinczenko, H. Mahtani, H. Rogers, R. Cleveland, L. Kass, P. Triozzi; East Lansing, United States 030 P1.09.19 - Characterization of Monocyte-Derived Dendritic Cells able to induce an E6/E7-specific, HLA I-restricted, cytotoxic activity Marco Iuliano, G. Mangino, S.M. Zangrillo, V.M. Chiantore, G. Fiorucci, G. Romeo; Latina, Italy 031 P1.09.20 - Inhibition of nitric oxide production and pro-inflammatory cytokines by several medicinal plants Fathollah Kalantar, Z. Amirghofran, S. Malek-Hossein, H. Golmoghaddam, M. Shabani; Shiraz, Iran, Islamic Republic of 032 P1.09.21 - Soluble TNFRp75 regulation of TNF-TNFRp55 dependent dendritic cell activation controls protective immunity against Mycobacterium tuberculosis Roanne S. Keeton, N. Allie, N. Hsu, P. Randall, M. Jacobs; Cape Town, South Africa 033 P1.09.22 - SHIP-1 Expression maybe involved in the endocytic functions of early bone marrow-derived dendritic cells but not myeloid derived suppressor cells Ying Ying Kong, M. Fuchsberger, S. Xiang, M. Hibbs, V. Apostolopoulos, M. Plebanski; Melbourne, Australia 034 P1.09.23 - Tofacitinib, a JAK inhibitor, induces tolerogenic phenotype in human dendritic cells Satoshi Kubo, K. Yamaoka, S. Iwata, M. Kondo, Y. Tanaka; Fukuoka, Japan 035 P1.09.24 - Estrogen receptor signaling and X-chromosome complement both independently contribute to the enhanced TLR-7-mediated responses of woman plasmacytoid dendritic cells Sophie Laffont, N. Rouquié, C. Seillet, J. Plumas, C. Aspord, J. Guéry; Toulouse, France 036 P1.09.25 - Bovine lactoferrin induces CCL1 production in myeloid cells Daniela Latorre, P. Puddu, P. Valenti, S. Gessani; Bellinzona, Switzerland 037 P1.09.26 - Baicalin from Scutellaria baicalensis impairs Th1 polarization through the inhibition of dendritic cell maturation M. Kim, Jun Sik Lee; Gwangju, Korea, Republic of 038 P1.09.28 - LAMP-2, a novel endocytic receptor on human monocytes derived dendritic cells (MDDC). Dario Leone; Vienna, Austria 199 Posters - August 26 039 P1.09.29 - Role of muscarinic activation in regulation of human dendritic cells maturation process María G. Lombardi, G. Salamone, P. Martinez Pulido, M.S. Gori, L. Ariolfo, J. Pimentel, M.E. Sales; CABA, Argentina 040 P1.09.30 - Growth phase-dependent immune response to Staphylococcus aureus Lisbeth D. Lund, Y. Souwer, H. Frokiar, E.C. de Jong; Frederiksberg C, Denmark 041 P1.09.31 - ESAT-6 and HspX improve the effectiveness of Bacille Calmette-Guérin to induce human Dendritic Cells-dependent T cells and Natural Killer cells activation Laura Marongiu, M. Donini, L. Toffali, E. Zenaro, S. Dusi; Verona, Italy 042 P1.09.32 - Dendritic cell CCAAT/ enhancer binding protein delta modulates Th17/Treg responses in an IL-10 dependent manner Mohammad G. Mohammad, V.W.W. Tsai, S.N. Breit, P.E. Sawchenko, D.A. Brown; Sydney, Australia 043 P1.09.33 - Study of leukemic cell products and IL-1β as modulators of human dendritic cells Juliana M. Motta, A. Sperandio, M.T.L. Castelo-Branco, V.M. Rumjanek; Rio de Janeiro, Brazil 044 P1.09.34 - Evaluation of the effect of the 14kDa protein isolated from aged garlic extract on dendritic cells Hasan Namdar Ahmadabad, M. Zuhair, M. Nezafat Firizi; Tehran, Iran, Islamic Republic of 045 P1.09.35 - IL-1 and IL-1 Receptor Antagonist Genes Polymorphism in ACPA Positive Rheumatoid Arthritis Patients Nardjess Ouikhlef, I. Allam, N. Raaf, A. Abdessamed, N. Bahaz, A. Tahiat, K. Cherguelaine, A. Ladjouze, R. DjiDjik, M. Ghaffor; Algiers, Algeria 046 P1.09.37 - Dendritic cell reprogramming by endogenously produced lactic acid A. Nasi, T. Fekete, A. Krishnamurthy, S. Snowden, É. Rajnavölgyi, A.G. Rothfuchs, A.I. Catrina, C.E. Wheelock, N. Vivar, Bence Rethi; Stockholm, Sweden 047 P1.09.38 - CD1c+ DCs are superior at stimulating Th2 cytokine production upon grass pollen stimulation compared to circulating basophils and pDCs Frida Rydnert, K. Lundberg, L. Greiff, M. Lindstedt; Lund, Sweden 048 P1.09.39 - Absence of Estrogen Receptor Alpha Reduces the Number and Function of Bone Marrow derived PDCA1+ cells in Lupus Prone Mice Jennifer L. Scott, G.S. Gilkeson, M. Cunningham, O. Naga; Charleston, United States 049 P1.09.40 - Endogenous production of activin A acts as negative regulator of NK-DC functional interactions Pascal Seeger, D. Bosisio, S. Parolini, R. Badolato, A. Gismondi, A. Santoni, S. Sozzani; Brescia, Italy 050 P1.09.41 - CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3 and Batf3 Cyril Seillet, J.T. Jackson, K.A. Markey, G.R. Hill, K.P.A. MacDonald, S.L. Nutt, G.T. Belz; Melbourne, Australia 051 P1.09.42 - β2 adrenergic receptor-mediated IL12p70 suppression in LPS-activated dendritic cells is IL-10and PKA-independent Maisa C.S. Takenaka, J.T. Maricato, V.M. Nascimento, M.G. Guereschi, L.P. Araujo, A.S. Basso; São Paulo, Brazil 052 P1.09.43 - Monocyte-derived dendritic cells pre-treated with TLR-3 and TLR-7 agonists express functional stability and Th17 polarization capacity in response to tumor conditioned media from colorectal cancer patients Sasa Vasilijic, D. Vucevic, I. Rajkovic, Z. Kostic, S. Jankovic, D. Mikic, M. Colic; Belgrade, Serbia 053 P1.09.44 - Agonistic anti-4-1BB mAb promotes the maturation and activation of hypoxic dendritic cells Qun Wang, C. Liu, Z. Dong, C. Guo, L. Zhang; Jinan, China 054 P1.09.45 - The equivalents of human blood and spleen DC subtypes can be generated in vitro from human CD34+ stem cells in the presence of Flt3L and TPO Li Wu, A. Proietto, D. Mittag; Beijing, China 055 P1.09.46 - Stat6 in dendritic cells negatively regulate IL-10 production and enhance arthritis Kunihiro Yamaoka, S. Kubo, M. Kondo, K. Maeshima, K. Nakano, K. Oshita, Y. Tanaka; Kitakyushu, Japan 056 P1.09.47 - PU.1 regulates CCR7 expression in dendritic cells Takuya Yashiro, M. Hara, K. Okumura, C. Nishiyama; Bunkyo-ku, Tokyo, Japan 057 P1.09.48 - Specialized role of skin dendritic cell subsets in induction of antigen-specific cellular and humoral immunity following intradermal vaccination Marija Zaric, O. Lyubomska, C. Scott, R. Donnelly, A. Kissenpfennig; Belfast, United Kingdom 058 P1.09.49 - Unique features of sublingual mucosal dendritic cells after antigen application Chenyang Zhang, T. Ohno, M. Azuma; Tokyo, Japan 200 Posters - August 26 P2.05 IMMUNE RESPONSES IN AGING Session Time: Monday, August 26, 13:20 - 15:00 059 P2.05.01 - How M. leprae Hsp65 influences the immune response in genetically selected aged mice? Estevam J. Baldon, E.B. Marengo, V. Bueno, M. De Franco, O.A. Sant’Anna; São Paulo, Brazil 060 P2.05.02 - Interferon signaling pathway: Intrahepatic expression of STAT 1 and interferon resistance in HCV patients Qudsia Bashir, A. Rashid, A. Naveed, R.S.A. Khan, S. Razak; Islamabad, Pakistan 061 P2.05.03 - Impact of Cytomegalovirus seropositivity on the lymphocytes counts in middle age individuals: increase of CD4+CD62L-CD28- lymphocytes in a sub-group of CMV+ individuals P. Apoil, B. Puissant-Lubrano, N. Congy-Jolivet, M. Peres, D. Bloom, F. Roubinet, Antoine Blancher; Toulouse, France 062 P2.05.04 - Reduced naïve CD8+ T-cell priming capacity in elderly and HIV infected individuals Olivia Y. Briceño, A. Lissina, G. Afonso, E. Gostick, D. Price, C. Katlama, U. Karrer, R. Mallone, D. Sauce, V. Appay; Paris, France 063 P2.05.05 - Is angiotensin-I converting enzyme (ACE) associated with immunosenescence? M.E. Ishimura, B. Viniauskas, D. Teixeira, J. Chagas, I.M. Longo-Maugeri, Valquiria Bueno; São Paulo, Brazil 064 P2.05.06 - SRC homology 2 domain-containing phosphatase-1 (SHP-1) is a negative T cell regulator of T lymphocyte responses associated with aging Tamas Fulop, A. Le Page, H. Garneau, N. Allard, K. Tsvetkova, A. Larbi, C. Fortin, G. Dupuis; Sherbrooke, Canada 065 P2.05.07 - MF59-induced ATP-signaling pathway is not impaired by immunosenescence thereby contributing to an efficient adjuvant activity in the elderly Marilena Gallotta, M. Taccone, M. Tortoli, M. Vono, A. Bonci, D. Casini, S. Bertholet, E. De Gregorio, D.T. O’Hagan, A. Seubert; Siena, Italy 066 P2.05.08 - The significance of thymic involution and the function of re-entryed T cells in thymus Yanan Gao, X. Pei, Y. Zhang; Beijing, China 067 P2.05.09 - Targeting macrophages rescues age-related immune deficiencies in geriatric mice Connie Jackaman, H.G. Radley-Crabb, Z. Soffe, T. Shavlakadze, M.D. Grounds, D.J. Nelson; Bentley, Australia 068 P2.05.11 - Crucial role of Menin in the regulation of CD4 T cell immunosenescence Makoto Kuwahara, T. Nakayama, M. Yamashita; Kisarazu-shi, Japan 069 P2.05.12 - Gender specific immune status differences in children and adults Julia Lagereva, S. Belyaeva; Ekaterinburg, Russian Federation 070 P2.05.13 - Lipid laden multilocular cells in the aging thymus are phenotypically heterogeneous Larissa G.P. Langhi, L.R. Andrade, M.K. Shimabukuro, D.D. Taub, R. Borojevic, V. de Mello-Coelho; Rio de Janeiro, Brazil 071 P2.05.14 - Ageing impairs macrophage phagocytosis: impact of altered cellular microenvironment? Eimear Linehan, D.C. Fitzgerald; Belfast, United Kingdom 072 P2.05.15 - The effect of anti-CMV response differs in nonagenarians and young controls: a transcriptomic analysis Saara Marttila, J. Jylhävä, M. Jylhä, A. Hervonen, M. Hurme; Tampere, Finland 073 P2.05.16 - Fetal microchimerism induces positive effects on the immune system of elderly individuals Tapio Nevalainen, J. Jylhävä, S. Marttila, T. Kuparinen, M. Jylhä, A. Hervonen, M. Hurme; Tampere, Finland 074 P2.05.17 - Bone marrow T cells from the femur are similar to iliac crest derived cells in old age and represent a useful tool for studying the aged immune system Theresa Pritz, K. Landgraf-Rauf, D. Herndler-Brandstetter, R. Rauf, J. Lair, R. Gassner, B. Weinberger, M. Krismer, B. Grubeck-Loebenstein; Innsbruck, Austria 075 P2.05.18 - Association analysis between CTLA-4 polymorphisms and bipolar disorder Alireza Rafiei, Z. Hosseini Khah, M. Taheri, S. Hosseini, M. Vesali; Sari, Iran, Islamic Republic of 076 P2.05.19 - Survival, proapoptotic proteins and TNFR induced in senil cataract Atzin Robles-Contreras, M. Arredondo-Flores, J.L. Oliva-Ramirez, C. Palacio-Pastrana, L.L. Arroyo, O. Guerrero-Berguer, H.J. Perez-Cano; Mexico city, Mexico 077 P2.05.20 - CMV infection associates to the expansion of polyfunctional CD8+CD57+ T cells in young individuals A. Pera, C. Campos, B. Sanchez-Correa, C. Alonso, R. Tarazona, Rafael Solana; Cordoba, Spain 201 Posters - August 26 078 P2.05.21 - Association between early development of cellular immunity to cytomegalovirus and Graft-Versus Leukemia effect in pediatric transplantation V. Guérin-El Khourouj, R. Porcher, S. Leveillé, J. LeGoff, B. Pédron, A. Baruchel, J. Dalle, Ghislaine Sterkers; Paris, France 079 P2.05.22 - Age influences the systemic inflammatory response in patients with community-acquired pneumonia Lonneke A. van Vught, H. Endeman, S.C.A. Meijvis, B.P. Scicluna, A.H. Zwinderman, D.H. Biesma, T. van der Poll; Amsterdam, Netherlands 080 P2.05.23 - Age-related changes in cell surface markers of BALB/C mice: A flow cytometric analysis Emine Yavuz, S. Hasgur, E.U. Bagriacik; Ankara, Turkey 081 P2.05.24 - irradiation indeces immune modification in splenocytes Yasuhiro Yoshida, Y. Song, R. Okazaki, T. Kanazawa; Kitakyushu, Japan 082 P2.05.25 - Cytomegalovirus infection impacts the development of CD4 memory T cells in young individuals Zdenek Zadrazil, A. Larbi, A. Vasudev; Singapore, Singapore P2.08 ANTIGEN RECEPTOR SIGNALING Session Time: Monday, August 26, 13:20 - 15:00 083 P2.08.01 - Functional relevance of NTAL adaptor cleavage M.M. Arbulo-Echeverria, F.J. Garcia-Cozar, Enrique Aguado; Cadiz, Spain 084 P2.08.02 - Analysis of TCR-Vβ repertoire in lung and blood lymphocytes of pulmonary sarcoidosis patients reveals presence of CD4+ and CD8+ T cell expansions Kerstin M. Ahlgren, T. Ruckdeschel, A. Eklund, J. Wahlström, J. Grunewald; Stockholm, Sweden 085 P2.08.03 - The contribution of ligand affinity of the inhibitory coreceptor ILT2 to differential patterning of TCR at the immune synapse Mina O. Aletrari, K. Sabaratnam, R. Zhang, S. Dyball, S. Seyedmohammad, M. Purbhoo; London, United Kingdom 086 P2.08.04 - Tollip-induced down-regulation of MARCH1 Marie-Claude Bourgeois-Daigneault, A. Pezeshki, T. Galbas, M. Houde, M. Baril, K. Früh, A. Amrani, S. Ishido, D. Lamarre, J. Thibodeau; Montreal, Canada 087 P2.08.05 - Intrinsic binding of V genes to autoantigens may contribute to BCR repertoire A.Q. Maranhão, B.W. Costa, P.M.M. Vieira, L. Guedes, M.E.T. Walter, T. Raiol, Marcelo M. Brigido; Brasilia, Brazil 088 P2.08.06 - PAG (Cbp) as a positive reulator of mast cell signaling Viktor Bugajev, L. Dráberová, M. Machyna, P. Dráber; Prague 4, Czech Republic 089 P2.08.07 - The phosphatase JKAP inhibits T-cell receptor signaling and autoimmunity by inactivating Lck Huai-Chia Chuang, J. Li, J. Lan, D. Chen, C. Yang, J.W. Belmont, T. Tan; Zhunan Miaoli County, Taiwan 090 P2.08.09 - Higher sensitivity of restored human CD8 T-cells to virus- and tumor-derived antigens Julia Fischer, S. Stevanovic, G. Grigoleit, T. Hünig; Würzburg, Germany 091 P2.08.10 - Regulation of AP-1 activation in T cells by EGR-2 Emma L.M. Ghaffari, T. Miao, A.L.J. Symonds, P.K. Bhullar, S. Li, P. Wang; London, United Kingdom 092 P2.08.11 - VAV1 controls inflammation in Experimental Autoimmune Encephalomyelitis (EAE) Andre O. Guerreiro-Cacais, M. N’Diaye, R. Berglund, A.D. Beyeen, M. Jagodic, T. Olsson; Stockholm, Sweden 093 P2.08.12 - Phage mini-antibodies and their use for detection of microbial cells by using electro-optical sensor Olga I. Guliy, l. Dykman, S. Staroverov, V. Bunin, O. Ignatov; Saratov, Russian Federation 094 P2.08.13 - Cdc42 controls cytokine secretion at the immune synapse Claire Hivroz, A. Bohineust, K. Chemin, S. Dogniaux, S. Guegan; Paris, France 095 P2.08.14 - OCILRP2 costimulates T cell activation by activating MAPK signaling pathway Yanzhong Hu; Kaifeng, Henan, China 096 P2.08.15 - Generation of LYPLA1 knockout Jurkat T cells by transcription activator-like effector nuclease (TALEN) technology D. Biedenweg, U. Jehmlich, A. Alahmad, Matthias Hundt; Greifswald, Germany 202 Posters - August 26 097 P2.08.18 - A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosomal-associated protein transmembrane 5 Yohei Kawano, R. Ouchida, J. Wang, S. Yoshikawa, D. Kitamura, H. Karasuyama; Tokyo, Japan 098 P2.08.19 - Detection of antigen-stimulated cytokine-secretion in human T-cells at single cell levels on a live cell chip Hiroyuki Kishi, A. Jin, H. Hamana, K. Tajiri, S. Hatakeyama, E. Kobayashi, T. Ozawa, T. Nagai, A. Muraguchi; Toyama, Japan 099 P2.08.20 - Recombinant P. aeruginosa outer membrane proteins and immune response A.V. Soldatenkova, L.A. Geiderova, E.A. Akhmatov, N.A. Mikhailova, N.K. Akhmatova, Olga V. Lebedinskaya; Perm, Russian Federation 100 P2.08.21 - Lck Mediates Signal Transmission from CD59 to the TCR/CD3 Pathway in Jurkat T Cells Anna M. Lipp, K. Juhasz, C. Paar, C. Ogris, P. Eckerstorfer, R. Thuenauer, J. Hesse, H. Stockinger, G.J. Schütz, U. Bodenhofer, Z. Balogi, A. Sonnleitner; Linz, Austria 101 P2.08.22 - The initiation of B cell receptor signaling is sensitive to the stiffness properties of the substrate presenting the antigens Wanli Liu, Z. Wan; Beijing, China 102 P2.08.23 - C-type lectin related protein OCILRP2 enhances development and functional differentiation of mouse bone marrow-derived dendritic cells Yuanfang Ma; Kaifeng, Henan China, China 103 P2.08.24 - Inhibition of PI3K/Akt pathway in antigen-stimulated B-lymphocytes and hybridoma cells induces their apoptotic death Yana Malyutina, Y. Makarova, A. Kabakov; Obninsk, Russian Federation 104 P2.08.25 - The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling Pieta K. Mattila, C. Feest, D. Depoil, B. Treanor, B. Montaner, K.L. Otipoby, R. Carter, L.B. Justement, A. Bruckbauer, F.D. Batista; Turku, Finland 105 P2.08.26 - CD22 ligand-binding and signalling domains reciprocally regulate B-cell Ca2+ signalling Jennifer Müller, I. Obermeier, M. Wöhner, C. Brandl, S. Mrotzek, P. Maity, M. Reth, L. Nitschke; Erlangen, Germany 106 P2.08.27 - Germline TSC1 mutations are permissive for T lymphocyte development and homeostasis in Tuberous Sclerosis individuals Karolina Pilipow, V. Basso, N. Migone, A. Mondino; Milan, Italy 107 P2.08.28 - Ligation of human Fc receptor like-2 (FCRL2) by specific monoclonal antibodies downregulates B cell receptor mediated signaling Mahdi Shabani, A.A. Bayat, M. Jeddi-Tehrani, H. Rabbani, C. Ulivieri, Z. Amirghofran, C.T. Baldari, F. Shokri; Tehran, Iran, Islamic Republic of 108 P2.08.29 - Cell membrane permeable phosphopeptides of Gab1 inhibit signaling in B cells by interacting with SHP-2 phosphatase Eszter Szarka, Á. Kertész, J. Varga, Á.S. Garai, G. Gógl, A. Reményi, T. Janáky, G. Váradi, G. Tóth, G. Sármay; Budapest, Hungary 109 P2.08.30 - Perturbing human TCR signaling pathway through superantigen from Staphylococcus aureus: Multi objective optimization under FBA Namrata Tomar, R.K. De; Kolkata, India 110 P2.08.31 - Suppression of T cells proliferation by A novel generated monoclonal antibody, COS3A Siriwan Wansook, S. Pata, K. Mahasongkram, W. Kasinrerk, P. Khunkaewla; Nakhonratchasima, Thailand P2.12 SIGNALLING IN IMMUNE CELLS Session Time: Monday, August 26, 13:20 - 15:00 111 P2.12.01 - Symmetry breaking in reconstituted actin cortices Enas Abu Shah, K. Keren; Haifa, Israel 112 P2.12.03 - Identification of signalling cascades during the inflammatory activation of phagocytes induced by S100A8 and S100A9 Selina Fassl, J. Austermann, M. Riemenschneider, A. Witten, M. Stoll, J. Roth, T. Vogl; Muenster, Germany 113 P2.12.04 - Type-1 serine/threonine phosphatases and PI3K signaling contribute for the TLR antagonist effect of Natterins Marcio José Ferreira, C. Lima, M. Lopes-Ferreira; São Paulo, Brazil 114 P2.12.05 - T cell proliferation defect of DiGeorge syndrome patients is associated with impaired CrKL signaling Mauro Giacomelli, R. Kumar, A. Prandini, A. Soresina, D. Moratto, S. Negri, O. Scomodon, A. Plebani, R. Badolato; Brescia, Italy 203 Posters - August 26 115 P2.12.06 - CD38/CD203a/CD73 runs in human T lymphocytes a novel adenosinergic loop independent from CD39 Alberto L. Horenstein, A. Chillemi, G. Zaccarello, V. Quarona, A. Zito, F. Malavasi; Turin, Italy 116 P2.12.07 - Genetically engineered chimeric molecules targeting Influenza A viral antigen Iva I. Ivanova, N. Mihaylova, N. Kerekov, A. Erdei, J. Prechl, A. Tchorbanov; Sofia, Bulgaria 117 P2.12.08 - Experimental and computational study of ROS and RNS in endothelial and leukocyte interactions Mahendra Kavdia, J. Chen, S. Kar; Detroit, United States 118 P2.12.09 - Arhgap12 as a novel binding partner of GULP regulates Rac1 activity during Stablin-2-mediated cell corpse engulfment Sang-Yeob Kim, D. Bae, S. Kim, H. Choi, J. Pyo, S. Park, I. Kim; Seoul, Korea, Republic of 119 P2.12.10 - Acetylation modulates Interleukin-2 receptor signaling Taku Kuwabara, M. Kondo; Ota-ku, Tokyo, Japan 120 P2.12.11 - Galphai2 and Galphai3 differentially regulate arrest and chemotaxis in neutrophils Yoshihiro Kuwano, M. Adler, H. Zhang, A. Groisman, K. Ley; Tokyo, Japan 121 P2.12.12 - RUNX transcription factors regulate the transcriptional activity of CD69 Teresa Laguna, L. Notario, P. Lauzurica; Majadahonda, Spain 122 P2.12.14 - The late endosomal transporter CD222 spatially regulates the distribution of proximal T cell signaling molecules Vladimir Leksa, K. Pfisterer, F. Forster, W. Paster, V. Supper, P. Eckerstorfer, C. Donner, H. Stockinger; Vienna, Austria 123 P2.12.15 - The activation and co-stimulatory functions of Fc receptor like 1 protein (FcRL1) in human B cells depend on phosphatidylinositol 3-kinase Chuen-Miin Leu, Y. Chen, T. Hsieh, G.R.A.A. Ehrhardt, M.D. Cooper; Taipei City, Taiwan 124 P2.12.16 - Sterile alpha motif (SAM) and individual H5 alpha helix mediates SLP-76 oligomer formation for microclusters and T-cell activation Hebin Liu, Y. Thaker, L. Stagg, H. Schneider, J. Ladbury, C.E. Rudd; SuZhou, China 125 P2.12.17 - Functionally Relevant phoshorylatable Serine Clusters targeted by Casein Kinase 2 on the Cytoplasmic region of the human CD6 Lymphocyte Surface Receptor L. Bonet, M. Farnós, M. Martínez-Florensa, V.G. Martinez, Francisco Lozano; Barcelona, Spain 126 P2.12.18 - Targeted mitochondrial antioxidant SkQ has anti-inflammatory properties in vitro and in vivo Alexander Lukashev, M. Skulachev; Moscow, Russian Federation 127 P2.12.19 - SAP-mediated inhibition of Diacylglycerol kinase alpha regulates TCR-induced diacylglycerol signaling and restimulation induced cell death in XLP patients G. Baldanzi, E. Ruffo, Valeria Malacarne, K.E. Nichols, L. Patrussi, C.T. Baldari, A. Snow, A. Graziani; Novara, Italy 128 P2.12.21 - The influence of calpain-calpastatin system in human lymphocyte - assessment of lymphocyte signaling process of centenarians and elderly people Anna Mikosik, A. Jasiulewicz, J. Frackowiak, J. Foerster, D. Schetz, J.M. Witkowski; Gdansk, Poland 129 P2.12.22 - CD157-extracellular matrix proteins interactions enhance integrin-mediated signalling cascade in monocytes Simona Morone, A. Giacomino, R. Parrotta, N. Lo Buono, M. Cuccioloni, E. Ortolan, A. Funaro; Torino, Italy 130 P2.12.23 - IL-21 isoform is a membrane-bound ligand and activates directly interacted cells Hidetoshi Nara, M. Rahman, A. Araki, L. Jin, Y. Takeda, H. Asao; Yamagata City, Japan 131 P2.12.24 - Differential TLR1/2 pro-inflammatory signaling during the first 9 months of life Elisa Nemes, M. Shey, W. Whatney, C. Riou, T. Scriba, W. Hanekom; Cape Town, South Africa 132 P2.12.25 - Dasatinib leads to a reduced number of B cells in mice and promotes apoptosis of human CD19+ peripheral blood B cells Morten P. Oksvold, C.B.F. Thien, S.A. Dagger, L. Forfang, J.H. Myklebust, E.B. Smeland, W.Y. Langdon; Oslo, Norway 133 P2.12.26 - Regulation of TCR trafficking and immune synapse assembly by Rab29 Anna Onnis, S. Spanò, F. Finetti, L. Patrussi, J.E. Galan, C.T. Baldari; Siena, Italy 134 P2.12.27 - A mutation in the moesin gene induces an alteration of T lymphocyte adhesion/migration process in a new combined immunodeficiency syndrome Farid Ouchani, C. Lagresle, S. Luce, K. Jacobs, C. Picard, A. Fischer, G. De Saint Basile, N. Jabado, M. Cavazzana-Calvo, I. André-Schmutz; Paris, France 204 Posters - August 26 135 P2.12.28 - Characterization of THEMIS as a novel attenuator of TCR signalling Wolfgang Paster, A. Bruger, C. Brockmeyer, G. Fu, A. Kabat, C. Wuelfing, N.R.J. Gascoigne, O. Acuto; Oxford, United Kingdom 136 P2.12.30 - Platelets and leukocytes reactivity in patients with ischemic stroke Iryna Prylutska, E. Barinov, O. Sulaieva, A. Kit; Donetsk, Ukraine 137 P2.12.31 - The chicken IFN- λ Receptor Complex Andreas Rohringer, K. Goossens, A. Ward, A. Bean; Geelong, Australia 138 P2.12.32 - A novel tool to isolate and analyze lipid rafts Philipp Schatzlmaier, J. Huppa, H. Stockinger; Vienna, Austria 139 P2.12.34 - IL-10 receptor and endoplasmic reticulum stress impairs STAT3 activation in type 1 diabetes patients and their healthy first degree relatives Mamdouh A.K. Sedhom, A. Cotterill, K. Irvine, R. Thomas; Woolloongabba, Brisbane, QLD, Australia 140 P2.12.35 - Enhanced expression of adenosine-producing ectonucleotidases in activated and memory T cells Ivan Shevchenko, A.V. Bazhin, V. Umansky; Heidelberg, Germany 141 P2.12.36 - Phenotypical analysis of transgenic mice expressing soluble human CD6 supports an immunomodulatory role for this protein Inês T. Simões, V.G. Martinez, R. Fenutría, J. Alberola-Ila, F. Lozano; Barcelona, Spain 142 P2.12.37 - Understanding signalling requirements of LTi cells in vivo and in vitro J. Wagner, Gleb Turchinovich, D. Finke; Basel, Switzerland 143 P2.12.38 - Elucidation of IL-17 signaling pathways Evgeny Varfolomeev, D. Vucic; South San Francisco, United States 144 P2.12.39 - Biological evaluation of human PBMC and Th17 cells using MILLIPLEX® MAP cell signaling and cytokine panels J. Hwang, T. Warmke, R. Keith, Rick Wiese; St Charles, United States 145 P3.08.26 - Bromodomain-Containing-Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells Joe, poh sheng Yeong, W. Zhang, P. Celine, C. Sum, N. Thiessen, S. Jones, S. Pettersson, S. Knapp, H. Yang, K. Chin; Singapore, Singapore P3.06 COSTIMULATION Session Time: Monday, August 26, 13:20 - 15:00 146 P3.06.01 - The effect of a high intensity interval exercise on the proliferative response of lymphocytes R. Tossige-Gomes, Karine Beatriz Costa, S.M. Magalhães, V.O. Ottone, F.C. Magalhães, F.T. Amorim, E. Rocha-Vieira; Diamantina, Brazil 147 P3.06.02 - Regulatory T cells control Th1 priming by inhibiting the CD70/CD27 pathway Maxime Dhainaut, C. Coquerelle, S. Uzureau, V. Acolty, J. Denoeud, G. Oldenhove, E. Pays, M. Moser; Gosselies, Belgium 148 P3.06.03 - XCR1 promotes the activation of CD8+ T lymphocytes by optimizing their interaction with CD8a+ dendritic cells Sonia Ghilas, K. Crozat, M. Dalod; Marseille, France 149 P3.06.04 - The Inducible Costimulator (ICOS) facilitates interleukin-4 synthesis through phosphoinositide 3-kinase signaling Mathieu Gigoux, A. Lovato, J. Leung, J. Leconte, N. Sonenberg, W. Suh; Montréal, Canada 150 P3.06.05 - Discovery of a novel immune checkpoint regulator of the B7 family that negatively modulates T cell activation Iris Hecht, J.R. Podojil, K. McNamee, I. Vaknin, A. Oren, A. Toporik, G. Cojocaru, G. Rotman, R. Williams, S.D. Miller; Tel Aviv, Israel 151 P3.06.06 - Nucleic acid-mediated T cell activation through a novel sensing mechanism induces Th2 responses Takayuki Imanishi, S. Akira, T. Saito; Yokohama, Japan 152 P3.06.07 - Semaphorin 4A regulates activation of CD8+ T cells Daisuke Ito, S. Nojima, A. Kumanogoh; Suita city, Japan 153 P3.06.08 - CD28 costimulates the CD4+ T cell tolerogenic response to exogenous antigen in vivo A. Jaekel, E. Mettke, Nele Reeg, Y. Yang, A. Hutloff, H. Mages, S. Gurka, R. Kroczek; Berlin, Germany 154 P3.06.09 - TIM-3 does not act as a receptor for galectin-9 Judith Leitner, K. Grabmeier-Pfistershammer, A. Rieger, W.F. Pickl, G. Zlabinger, P. Steinberger; Vienna, Austria 205 Posters - August 26 155 P3.06.10 - Endothelial-lymphocyte interaction causes proliferation and transient Foxp3 enrichment of CD4+ T lymphocytes Wen Chean Lim, E. Healy, T.M. Millar; Southampton, United Kingdom 156 P3.06.11 - Setting an intrinsic brake on T cell division number: Roles for TCR affinity and IL-2 concentration Julia M. Marchingo, S. Heinzel, C.J. Wellard, M.R. Dowling, P.D. Hodgkin; Melbourne, Australia 157 P3.06.12 - Role of metalloprotease ADAM17 in regulating ICOSL-mediated humoral immune response Joanna Marczynska, A. Ozga, A. Włodarczyk, D. Michalczyk, M. Bana , M. Kwitniewski, A. Hutloff, J. Scheller, S. Rose-John, J. Cichy; Kraków, Poland 158 P3.06.13 - IL-35 is induced in human T cells upon co-stimulation via CD43 and PD-1 Madhura Modak, M. Seyerl, R. Aigner, O. Majdic, D. Olive, G. Zlabinger, J. Stöckl; Vienna, Austria 159 P3.06.14 - High throughput generation of antibody secreting B-cell clones from peripheral blood of rabbits Sonja Offner, F. Ros, I. Thorey, G. Tiefenthaler, K. Kaluza, V. Lifke, J.A.A. Fischer, S. Klostermann, J. Endl, E. Kopetzki, A. Pashine, B. Kaluza, J. Platzer, S. Seeber; Penzberg, Germany 160 P3.06.15 - Co-stimulatory effects of PD-1 in sublingual mucosa-mediated CD4+ T cell responses Tatsukuni Ohno, C. Zhang, H. Yagita, M. Azuma; Tokyo, Japan 161 P3.06.16 - Combining molecular adjuvant or a sub-immunizing dose of inactivated Foot and Mouth Disease Virus (FMDV) with plasmids encoding P12A3C or VP1 protein enhances DNA vaccine potency Erica Pereyra, V. Gnazzo, I. Soria, C. Langellotti, C. Bellusci, A. D´Antuono, M. Nora, V. Quattrocchi, P. Zamorano, C. Mongini; Buenos Aires, Argentina 162 P3.06.17 - The impact of CD27 signaling on Wnt-mediated T cell expansion Carla Ruckstuhl, C. Schürch, C. Riether, A. Ochsenbein; Bern, Switzerland 163 P3.06.18 - Constitutively active STAT3 acts as a tolerogenic factor in human CD4+ T-cells Klaus G. Schmetterer, A. Neunkirchner, D. Wojta-Stremayr, J. Leitner, P. Steinberger, W.F. Pickl; Vienna, Austria 164 P3.06.19 - Adapters TRIM and LAX regulate transport and surface expression of CTLA-4 via Rab8 vesicles Helga Schneider, M.C. Banton, K.L. Inder, E. Valk, C.E. Rudd; Cambridge, United Kingdom 165 P3.06.20 - Signaling through Flt3 on activated splenic B-cells drives plasma cell differentiation Mattias N.D. Svensson, K. Månsson, K.M.E. Andersson, M. Bemark, M. Brisslert, M. Bokarewa; Gothenburg, Sweden 166 P3.06.21 - PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model Horng-Tay Tzeng, P. Chen, P. Hsu; Taipei, Taiwan 167 P3.06.22 - Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells Ei Wakamatsu, R. Abe, D. Mathis, C. Benoist; Noda, Japan 168 P3.06.23 - The immunomodulatory potency of interleukin 2 applied as ‘natural adjuvant’ bound to virus-like nanoparticles is critically influenced by its membrane-anchor characteristics Daniela Wojta-Stremayr, A. Neunkirchner, K.G. Schmetterer, W.F. Pickl; Vienna, Austria P4.06 IMMUNITY TO FUNGAL INFECTION Session Time: Monday, August 26, 13:20 - 15:00 169 P4.06.01 - Anti-aspergillus fumigatus IgY antibodies and their protective efficacy in immunocompromised BALB/c mice K. Kissoyan, N. Al-Akl, Alexander Abdelnoor; Beirut, Lebanon 170 P4.06.02 - HeNe laser increases the pro-inflammatory cytokines production and the in vitro phagocytosis of P. brasiliensis by macrophages Thiago Alves da Costa, R. Thomé, R. Di Gangi, C. Francelin, L. Verinaud; Campinas, Brazil 171 P4.06.03 - Cryptococcus gattii infection inhibits the induction of Th1 immune responses Pornpimon Angkasekwinai, M. Chayakulkeeree; Pathumthani, Thailand 172 P4.06.04 - Disentangling immunity and tolerance in candidiasis Antonella De Luca, A. Carvalho, C. Cunha, G. Giovannini, L. Bartolommei, S. Moretti, C. Massi-Benedetti, M. Puccetti, R.G. Iannitti, L. Romani; Perugia, Italy 173 P4.06.05 - Paracoccidioides brasiliensis induces neutrophil extracellular traps in vitro Tatiana F. Bachiega, R.K. Fernandes, D.R. Rodrigues, H.A. Balderramas, L.A. Dias-Melicio, Â.M.V.C. Soares; Botucatu, Brazil 206 Posters - August 26 174 P4.06.06 - Characterization of Regulatory T Cells in Pulmonary Paracoccidioidomycosis Using Foxp3-GFP Transgenic Mice Silvia Boschi Bazan, T. Costa, V. Calich; São Paulo, Brazil 175 P4.06.07 - Deciphering the class and specificity of the T cell response to C. albicans Simone Becattini, F. Mele, G. Gyuelveszi, L. Perez, A. Sette, A. Lanzavecchia, F. Sallusto; Bellinzona, Switzerland 176 P4.06.08 - Variability in autologous/heterologous binder serum activity anti-Candida albicans and relationship with oral presence of the yeast, in patients with risk factors Daniela Brito, N. Semprún- Hernández1, J. Puentes, S. Azuero; maracaibo, Venezuela, Bolivarian Republic of 177 P4.06.09 - Granulomas developed in paracoccidioidomycosis in oral lesions of patients and in experimentally infected mice present similar patterns Eva Burger, M. Miyazawa, D.T. Oliveira, A.A.C. Pereira, M.L. deCarli, I. Felipe, J.A.C. Hanemann; Alfenas, Brazil 178 P4.06.10 - Cutaneous candidiasis in BALB/c mice Tacito G. Campois, A.Z. Zucoloto, G.F.S. Quirino, L.A. Custodio, I.C. Costa, E.E.J. Araújo, T.I.E. Svidzinski, I. Felipe; Londrina, Brazil 179 P4.06.11 - Immune response investigation in a murine model of sporotrichosis L. Souza Ferreira, L. Carolina de Abreu Ribeiro, D. Cardoso Geraldo Maia, T. de Cássia Negrini, P. Alegranci, D. Cordeiro de Matos, M. Bassi Quiles, M. Campos Polesi Placeres, Iracilda Zeppone Carlos; Araraquara, Brazil 180 P4.06.12 - Identification of NETs (neutrophil extracellular traps) in tegumentary lesions of patients with paracoccidioidomycosis Amanda M.D. Coletta, T.F. Bachiega, J.C.Q. Silva, B.R.S. Silva, S.A. Marques, M.E.A. Marques, J. Defaveri, A.M.V.C. Soares, L.A. Dias-Melicio; Botucatu, Brazil 181 P4.06.13 - High-throughput miRNA sequencing of human monocyte-derived dendritic cells confronted with Aspergillus fumigatus Kristin Czakai, I. Leonhardt, M. Walter, M. Bonin, O. Kurzai, H. Einsele, J. Loeffler; Wuerzburg, Germany 182 P4.06.14 - Involvment of Notch-TLR signaling in experimental paracoccidioidomycosis Lavínia M. Dal’Mas Romera, S.R. de Almeida; São Paulo, Brazil 183 P4.06.15 - Thymic alterations during Paracoccidioides brasiliensis infection Rosaria Di Gangi, T. Alves da Costa, C. Francelin, R. Thomé, L. Verinaud; Campinas, Brazil 184 P4.06.16 - Anti-DEC-205 receptor carrying P10 induces protective response in experimental Paracoccidioidomycosis Suelen S. Dos Santos, E. Rampazzo, K.S. Ferreira, C.P. Taborda, S.B. Boscardin, S.R. Almeida; Sao Paulo, Brazil 185 P4.06.17 - Concanavalin-A induces IL-17 production during the course of Candida albicans infection Ionice Felipe, P.G.C. de Carvalho, L.A. Custodio, I. Conchon-Costa, C.G.T.J. Andrade, G.F.S. Quirino, E. Burger, R.S. Almeida; Londrina, Brazil 186 P4.06.18 - Inhibition of PGE2 and LTB4 production by dendritic cells induced by Paracoccidioides brasiliensis is associated with the non maturation of these cells Reginaldo K. Fernandes, T.F. Bachiega, D.R. Rodrigues, M.A. Golim, L.A. Dias-Melicio, H.A. Balderramas, R. Kaneno, Â.M.V.C. Soares; Botucatu, Brazil 187 P4.06.19 - Therapy with scFv transfected-dendritic cells induce a decrease levels of specific IgG2b upon Paracoccidioides brasiliesnsis infection G.P.J. Jannuzzi, J.R.F.A. Almeida, S.R.A. Almeida, Karen S.F. Ferreira; Diadema, Brazil 188 P4.06.20 - In pulmonary paracoccidioidomycosis, IDO exerts a protective effect to susceptible mice but a deleterious effect to resistant mice Eliseu Frank de Araujo, V.L.G. Calich; São Paulo, Brazil 189 P4.06.21 - Evaluation of infiltration with important acquired immune cells in kidney and spleen of mouse model in groups affected by systemic candidiasis, treated by etanolic extract of Zataria multiflora Boiss. in comparison to control groups Hadi Ghazanfari, N. Hassannejad, M. Bayat, P. Dehghan, S. Hejazi, S. Ghanadian; Isfahan, Iran, Islamic Republic of 190 P4.06.23 - Differential immune reactivity of Paracoccidioides brasiliensis phylogenetic species S1, PS2 and P. lutzii antigens by paracoccidioidomycosis patients` sera Eiko N. Itano, A. Lenhard-Vidal, J.P. Assolini, A. Sano, C.S.O. Bredt, M.A. Ono; Londrina, PR, Brazil 191 P4.06.25 - Protein-based Mycosis Vaccines: Mechanism and Prospects for Future Human Use Markus Kalkum, D. Diaz-Arevalo, J. Champer, T.B. Hong, K. Vega, J.I. Ito; Duarte, United States 192 P4.06.26 - Preliminary evaluation of antigens from Paracoccidioides brasiliensis responsible for protective immune response induced in P. brasiliensis-infected mice by treatment with complete Freund’s adjuvant Taise N. Landgraf, F.F. Fernandes, G. Peron, A.A.M. Coelho-Castelo, A. Panunto-Castelo; Ribeirão Preto, Brazil 207 Posters - August 26 193 P4.06.27 - CD5 modulates the inflammatory response to fungal cell wall components Marc Orta, E. Carreras, R. Fenutría, I. Simões, C. Raman, F. Lozano; Barcelona, Spain 194 P4.06.28 - Host parasite interaction in Drosophila melanogaster Francesco Paparazzo, S. Hutter, A. Tellier, W. Stephan; Martinsried, Germany 195 P4.06.29 - Inhibition of neutrophil extracellular traps (NETs) by Cryptococcus neoformans: involvement of the capsular polysaccharide Glucuronoxylomannan (GXM) Juliana D.B. Rocha, M.M.T.C. Nascimento, M.P. Nunes, D. Decote-Ricardo, G.A. DosReis, E.M. Saraiva, C.G. Freire-de-Lima; Rio de Janeiro, Brazil 196 P4.06.30 - The resistance to infection by Paracoccidioides brasiliensis requires production of IL-6, IL-17 and IL-23 Fernanda A. Rocha, N. Ketelut-Carneiro, J.S. Silva; Ribeirão Preto, Brazil 197 P4.06.31 - In situ expression of regulatory cytokines in oral paracoccidioidomycosis lesions Denise B.R. Rodrigues, M.S. Araujo, P.M. Alves, S.A.L. Pereira, L.M.B. Lima, M.F. Silva, V. Rodrigues; Uberaba, Brazil 198 P4.06.32 - Interferon-gamma production by human neutrophils upon challenge with Paracoccidioides brasiliensis Daniela R. Rodrigues, R.K. Fernandes, H.A. Balderramas, T.F. Bachiega, S.A. Calvi, L.A. Dias-Melicio, M. Penitenti, M.R.V. Ikoma, A.M.V.C. Soares; Botucatu, Brazil 199 P4.06.33 - Interaction between monocyte-derived dendritic cells from active and cured paracoccidioidomycosis patients and Paracoccidioides brasiliensis antigens: differences on phenotype, cytokines release and lymphoproliferation Paula K. Sato, T.M. Oshiro, É.C. Passos, C.L. Diogo, C.A. Fonseca, M.A. Shikanai-Yasuda; São Paulo, Brazil 200 P4.06.34 - Frequencies of Heterologous Serum Agglutination (FHSA) Heterologous Representativeness Index (HRI) and Autologous Reactivity as indicators of variability in binder activity anti-Candida albicans - Evaluation in age groups of healthy individuals carriers of the yeast in oral cavity Neomar Semprún Hernández, A. Bohórquez Visier, M. Ribas, R. Colmenares, S. Azuero; Cabimas, Venezuela, Bolivarian Republic of 201 P4.06.35 - IL-18 does not modulate dectin-1 expression on human monocytes challenged with Paracoccidioides brasiliensis M.B. Cestari, T.F. Bachiega, R.K. Fernades, Juliana C.Q. Silva, M.A. Golim, A.M.V.C. Soares, L.A. Dias-Melicio; Botucatu, Brazil 202 P4.06.36 - Dectin-1 plays a prominent role in the immune response against the dermatophyte “Trichophyton rubrum” in murine model Fábio S.Y. Yoshikawa, S.R. de Almeida; São Paulo, Brazil 203 P4.06.37 - The role of IL-6 and IL-8 in vulvovaginal candidiasis in adolescent Girls Uktam K. Ziyadullaev; Tashkent, Uzbekistan P4.07 IMMUNITY TO HELMINTH INFECTION Session Time: Monday, August 26, 13:20 - 15:00 204 P4.07.01 - Involvement of Treg and alternatively activated macrophages in evasion strategies during hydatidosis Manel Amri, C. Touil-Boukoffa; Algiers, Algeria 205 P4.07.02 - Galectin-like molecule in parasite inhibits remission of experimental autoimmune encephalomyelitis by enhancing auto-reactive B cells So Jin Bing, D. Ha, S. Lee, J. Cho, S. Park, H. Yu, Y. Jee*; Jeju, Korea, Republic of 206 P4.07.03 - Anisakis simplex allergens remain biologically active after canning and simulated gastric fluid treatment of parasitized fish Noelia Carballeda-Sangiao, A. Rodríguez-Mahíllo, F. Olivares Ponce, M. Tejada, M. Careche, I. Moneo, M. Gonzalez-Muñoz; Madrid, Spain 207 P4.07.04 - Immunomodulatory effect of Toll-like receptor 7/8-agonist (imidazoquinoline Resiquimod) in experimental secondary hydatidosis infection Margherita Conchedda, V. Seu, A. Caddori, A. Caredda, F. Gabriele; Monserrato (Cagliari), Italy 208 P4.07.05 - Immunomodulation by TLR-7-agonist, IL-27 or IL-25 in Hymenolepis diminuta infection in rats Margherita Conchedda, V. Seu, S. Capra, A. Caredda, F. Gabriele; Monserrato (Cagliari), Italy 209 P4.07.06 - An essential role of galectin-1 in driving Th2-polarized responses during helminth infection Sebastian Dergan Dylon, J. Ilarregui, L. Rutitzky, M. Stadecker, G. Rabinovich; Buenos Aires, Argentina 210 P4.07.07 - The change of CD4+CD25+ regulatory T cells and related cytokines in mice infected with Echinococcus multilocular Jian-Bing Ding, X. Ma, H. Zhao, Y. Zhu, F. Zhang, H. Wen; Urumqi,Xinjiang, China 208 Posters - August 26 211 P4.07.08 - Heligmosomoides polygyrus L4 stage from inflammatory milieu effects on dendritic precursor JAWSII cells K. Donskow-Lysoniewska, K. Brodaczewska, Maria Doligalska; Warsaw, Poland 212 P4.07.09 - Chitosan stimulates lymphocyte proliferation during muscle phase of Trichinella spiralis infection in mice K. Brodaczewska, N. Wolaniuk, K. Donskow-Lysoniewska, Maria Doligalska; Warsaw, Poland 213 P4.07.10 - The role of TLR3 in the development of a protective immune response against Plasmodium Marion Draheim, J. Roland, S. Pied; Lille, France 214 P4.07.11 - Oral Fluids: utility in parasitic infections diagnosis Yousr Galaï, M. Benabid, F. Amri, K. Aoun, A. Bouratbine; Belvedere Tunis, Tunisia 215 P4.07.12 - Schistosomiasis vaccine discovery using high throughput schistosome tegument proteins microarray recognition Soraya T. Gaze Jangola, P. Driguez, J. Bethony, D. MacManus, D. Doolan, R. Correa-Oliveira, P. Felgner, A. Loukas; Belo Horizonte, Brazil 216 P4.07.14 - Differential expression of ovine TLR2 and TLR4 in peripheral blood mononuclear cells cultured with hydatid cyst derived antigens Alireza Haghparast, N. Soleymani, H. Borji, A. Naghibi, F. Taran, J. Mehrzad, M. Nazem Shirazi, M. Torabi; Mashhad, Iran, Islamic Republic of 217 P4.07.15 - Induction of regulatory T cells by Opisthorchis viverrini Chamraj Kaewraemruaen, R.W. Sermswan, S. Wongratanacheewin; Khon Kaen, Thailand 218 P4.07.16 - Down regulation of NKG2D and Fc gamma receptor I in peripheral blood mononuclear cells induced by excretory-secretory antigens from the third stage Gnathostoma spinigerum larvae (L3) Yaowapa Maneerat, S. Benjathammaraksa, Y. Eshita, R. Kumsiri, K. Wetchabut, S. Nuamtanong, T. Kalambaheti, J. Waikagul; BKK, Thailand 219 P4.07.17 - Swiprosin-1/EFhd2 limits autoantibody and IgE levels by restricting co-stimulation dependent B cell activation S. Brachs, A. Turqueti-Neves, C. Lang, B. Brachvogel, M. Bösl, T. Winkler, D. Voehringer, H. Jäck, Dirk Mielenz; Erlangen, Germany 220 P4.07.18 - Regulation of intestinal immune response by selective removal of the anterior, posterior, or entire pituitary gland in Trichinella spiralis infected golden hamsters R. Hernández-Cervantes, A. Quintanar-Stephano, V. López-Salazar, L. López-Griego, R. Hernández-Bello, J.C. Carrero, K.E. Nava-Castro, Jorge Morales-Montor; México, D.F., Mexico 221 P4.07.19 - The effects of astaxanthin in improving age associated declines of Th2 immune responses Motoko Morimoto, S. Abe, N. Azuma, S. Kamei, K. Dewa; Sendai City, Miyagi, Japan 222 P4.07.20 - Dendritic cell capture and transfer of HIV-1 to CD4+ T lymphocytes is inhibited by helminth parasite antigens Emily E.I.M. Mouser, H.H. Smits, M. Yazdanbakhsh, E.C. de Jong, G. Pollakis, W.A. Paxton; Amsterdam, Netherlands 223 P4.07.21 - Helminth infection alters mood and short-term memory as well as neurotransmitter and cytokine levels in the mouse hippocampus Karen E. Nava-Castro, J. Morales-Montor, O. Picazo, H. Besedovsky, R. Hernández-Bello, L. López-Griego, E. Becerril, J. Moreno, L. Pavón, I. Camacho-Arroyo; México, D.F., Mexico 224 P4.07.22 - CD28 is required for protection against Nippostrongylus brasiliensis secondary infection and recall of memory responses in inducible CD28 deleting mice Hlumani H. Ndlovu, M. Darby, M. Froelich, W. Horsnell, F. Ludher, T. Hunig, F. Brombacher; Cape Town, South Africa 225 P4.07.23 - Analysis of Schistosoma mansoni candidate antigens as diagnostic targets for schistosomiasis P. O. Ogongo, A.R. Wilson, Thomas M. Kariuki; Nairobi, Kenya 226 P4.07.24 - Leukocyte adhesion to mesenteric endothelial cells mediated by P2Y1 receptor activation during schistosomiasis Suellen D.S. Oliveira, N.F. Oliveira, R. Coutinho-Silva, C.L.M. Silva; Rio de Janeiro, Brazil 227 P4.07.25 - Purinergic signaling in mesenteric endothelial cells and peritoneal macrophages in chronic inflammation Suellen D.S. Oliveira, N.F. Oliveira, J.R. Meyer-Fernandes, C.L.M. Silva, R. Coutinho-Silva; Rio de Janeiro, Brazil 228 P4.07.26 - Atopic responses among pre-school children in a schistosomiasis endermic community in Zimbabwe Noah H. Paul, N. Rujeni, F. Chidzwondo, N. Midzi, F. Mutapi, T. Mduluza, T. Mduluza, T. Mduluza, T. Mduluza, T. Mduluza, T. Mduluza; Harare, Zimbabwe 229 P4.07.27 - Impaired CXCR4/CXCL12 chemokine receptor/ligand axis limits filarial infection Nicolas Pionnier, E. Brotin, G. Karadjian, N. Vallarino-Lhermitte, A. Nieguitsila, P. Hémon, M. Aknin, F. Bachelerie, C. Martin; Paris, France 230 P4.07.28 - Opisthorchis viverrini induces Th17 cytokine responses in hamsters Supavadee Polyiam, Y. Huang, R. Anderson, S. Wongratanacheewin, R.W. Sermswan; Khon Kaen, Thailand 209 Posters - August 26 231 P4.07.29 - Study of nitric oxide metabolites(NOx) production during human hydatidosis: Relationship with cyst fertility Zeghir-Bouteldja Razika, T. Chafia; Algeria, Algeria 232 P4.07.30 - Evaluation of CCA urine test for diagnosis of Schistosoma mansoni infection in Brazil Alda M.S. Silveira, C. Caffrey, M.H. Hsieh, D. Ray, B. Suzuki, L.A.O. Fraga; Governador Valadares, Minas Gerais, Brazil 233 P4.07.31 - High IL-4 production related to granuloma development in high-tolerogenic mice infected with Schistosoma mansoni Daniel A. Tavares, A.C. da Silva, A.M.L. Xavier; Rio de Janeiro, Brazil 234 P4.07.32 - Reduction of B lymphocytes production in mice genetically selected for humoral response and infected with Schistosoma mansoni Aurelizia M.L. Xavier, M.F.S. da Silva, E. Hayashi, A.C. da Silva, D.A.G. Tavares; Niteroi, Brazil 235 P4.07.33 - Ultrastructural alterations in adult Schistosoma mansoni harbored in low-inflammatory mice Aurelizia M.L. Xavier, M.F.S. da Silva, E.V. Guimarães, A.C. da Silva, A.H.A. Moraes Neto, D.A.G. Tavares; Niteroi, Brazil 236 P4.07.34 - Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in Strongyloides venezuelensis-infected mice Koubun Yasuda, T. Muto, M. Matsumoto, Y. Sasaki, K. Matsushita, T. Yoshimoto, K. Nakanishi; Nishinomiya, Japan P4.08 IMMUNITY TO PROTOZOAN PARASITE INFECTION Session Time: Monday, August 26, 13:20 - 15:00 237 P4.08.01 - CCL3, CCL4 and CXCL8 chemokines mRNA expression in human neutrophils in response to Leishmania infantum A. Hematzadeh, S. Pakzad, T. Naji, Soheila Ajdary; Tehran, Iran, Islamic Republic of 238 P4.08.02 - Trypanosoma cruzi oral/intragastric infection in murine model: infection and immune response features of the host Juliana B. Albuquerque, D.S. Santos, L.R. Berbert, C.E. Carvalho-Pinto, A.R. Pérez, O. Botasso, E. Roggero, R. Manarin, W. Savino, J. de Meis; Rio de Janeiro, Brazil 239 P4.08.03 - Congenital infection with Trypanosoma cruzi primes cord blood Vδ2 T cells to proliferate in response to isopentenyl pyrophosphate Cristina Alonso-Vega; Cochabamba, Bolivia, Plurinational State of 240 P4.08.04 - Phenotypic and functional analysis of CD4+FoxP3+ regulatory T cells (TREG) in the early phase of murine infection with Trypanosoma cruzi B. Villas-Bôas, R.S. do Nascimento, M. D’Império-Lima, José M. Alvarez; São Paulo, Brazil 241 P4.08.05 - Phagocyte-derived from cells B1 (B1CDP) facilitate Leishmania major infection in vitro via IL-10 and PGE-2 secretion Angélica F. Arcanjo, I.F. La Roque de Freitas, J.D.B. Rocha, M.P. Nunes, A. Popi, M. Mariano, C. Bandeira-de-Melo, G.A. DosReis, D. Decote-Ricardo, C.G. Freire-de-Lima; Rio de Janeiro, Brazil 242 P4.08.06 - Analysis of Metalloproteinases and their Inhbitors in Chronic Chagas’Cardiomyopathy Monique A. Baron, P.C. Teixeira, R.H. Santos, E.C. Mairena, I.C. Navarro, N.A. Stolf, A. Fiorelli, J. Kalil, L.R.P. Ferreira, E.C. Neto; São Paulo, Brazil 243 P4.08.07 - Role of IL-9 in the intestinal inflammation induced after Toxoplasma gondii infection Luciana Benevides, M.S. Dias, M. Souza, D.M. Fonseca, J.S. Silva; Ribeirão Preto, Brazil 244 P4.08.08 - Splenic phagocytes shape the immunity to Plasmodium infection in distinct but complementary ways Henrique Borges Da Silva, P.J. Spence, S. Reece, J. Thompson, N. Van Rooijen, J. Langhorne, C. Tadokoro, M.R. D’Império Lima; São Paulo, Brazil 245 P4.08.09 - Neutrophil migration during placental malaria Stéphanie Boström, A. van der Does, B. Amulic, M. Troye-Blomberg; Stockholm, Sweden 246 P4.08.10 - Histopathological study in intestinal wall of dogs naturally infected with Leishmania in the intestines Wilma A. Buzetti, D.T. Silva, M.F. Neves, A.G.S. Lins; Ilha Solteira, Brazil 247 P4.08.11 - Comparative evaluation of rK39 and soluble antigen ELISA, IFAT and parasitological tests for Canine Visceral Leishmaniasis diagnosis D.T. Silva, Wilma A.S. Buzetti, M.F. Alves, M.S. Paixão, M.S. Tenorio; Ilha Solteira, Brazil 248 P4.08.12 - Role of L-arginine during acute phase of Chagas disease in pregnant Wistar rats infected with the Y strain of Trypanosoma cruzi Ana A. Carraro Abrahão, C.M. Bronzon da Costa, M.R. Barbosa de Freitas, V. Brazão, C.D. dos Santos, C.C. Kuehn, M.A. Sala, J.C. do Prado Júnior; Ribeirão Preto, Brazil 210 Posters - August 26 249 P4.08.13 - Zinc intake improves immune response during pregnancy in wistar rats infected with Y strain of Trypanosoma cruzi Ana A. Carraro Abrahão, C.M. Bronzon da Costa, M.R. Barbosa Freitas, V. Brazão, C.D. Santos, M.A. Sala, J.C. Prado Júnior; Ribeirão Preto, Brazil 250 P4.08.14 - T cell immunoglobulin- and mucin-domain-containing molecule-3 secretion by patients with active cutaneous leishmaniasis Lucio R. Castellano, D. Correia, M.V. Silva, H. Dessein, A. Dessein, V. Rodrigues; João Pessoa, PB, Brazil 251 P4.08.15 - Trypanosomiasis-associated modulation of B cell lymphopoiesis and immune function Jennifer Cnops, V. Bockstal, F. Kauffmann, P. Garside, M. Radwanska, C. De Trez, S. Magez; Brussels, Belgium 252 P4.08.16 - Towards an immunosense vaccine to prevent toxoplasmosis Hua Cong, Q. Yuan; Jinan, China 253 P4.08.17 - Effect of congenital toxoplasmosis on the uNKs cells population and their products in a mouse model Dolores Correa, A. Besné-Mérida, C. Cedillo-Peláez, C. Rico-Torres, F. García-Vázquez, J. Farfán-Morales, J. Vargas-Villavicencio; Mexico, Mexico 254 P4.08.18 - Metalloproteinases 2 and 9 are differentially expressed in patients with indeterminate and cardiac clinical forms of Chagas disease Rodrigo Correa-Oliveira, J.A.S. Gomes, L.R. Garzoni, M.M. Saraiva, R.M. Saraiva, R.M. Saraiva, L.C. Sangenis, M.C. Chambela, F.F. Araujo, A. Teixeira-Carvalho, M.P. Damasio, V.A. Valente, K.S. Ferreira, G.R. Souza, M.O.C. Rocha; Belo Horizonte, Brazil 255 P4.08.19 - Kinetics of the IgG antibodies acquisition in Plasmodium vivax infected individuals living in a low malaria transmission area in Brazil Maristela G. Cunha, M.M. Póvoa, E.S. Silva, A.M. Ventura, M.D. Ohnishi, N. Sepulveda, P.H. Corran, E. Riley, C. Drakeley; Belém, Brazil 256 P4.08.20 - Molecular basis of CD8+T cell’s protective response to Toxoplasma infection W. Gao, H. Chu, E. Robey, Shaodong Dai; Denver, United States 257 P4.08.21 - NOD2-dependent Th1 response impairs host survival during N. caninum infection Marcela Davoli Ferreira, C. Martins Mota, D. Morais da Fonseca, D. Lima Junior, J. Santana da Silva, T. Mineo; Ribeirão Preto, Brazil 258 P4.08.22 - Glucocorticoid mediated caspase-8 and caspase-9 activation promotes thymocyte apoptosis and thymus atrophy in Trypanosoma cruzi infection D.A. Farias-de-Oliveira, D.M.S. Villa-Verde, P.H.N. Panzenhagen, D.S. dos Santos, L.R. Berbert, W. Savino, Juliana de Meis; Rio de Janeiro, Brazil 259 P4.08.23 - Melatonin and lycopene role on immune system against Chagas’disease José Clóvis do Prado Júnior, M.D. Filipin, V. . Brazão, M.A. Toldo, F.H. Santello; Ribeirão Preto, Brazil 260 P4.08.24 - Impact of the absence of galectin-3 on the course of experimental Trypanosoma cruzi infection Danielle S. dos Santos, J.B. de Albuquerque, L.R. Berbert, D.A. Farias-de-Oliveira, L.V.C. Guillermo, W. Savino, J. de Meis, D.M.S. Villa-Verde; Rio de Janeiro, Brazil 261 P4.08.25 - Casein diets prevent experimental cerebral malaria by enhancing host pro-inflammatory immune responses during early stage Yonghui Feng, X. Sun, X. Wei, J. Liu, Y. Cao; Shenyang, China 262 P4.08.26 - Association of IL-1β in the severity of diffuse cutaneous leishmaniasis Edith Fernández, C. Rangel, K. Carrillo, N. Salaiza, I. Becker; Mexico, Mexico 263 P4.08.27 - Oxidized ATP action on macrophage during infection with Leishmania amazonensis Vanessa R. Figliuolo da Paz, S.P. Chaves, G.F. Santoro, C.M.L.M. Coutinho, J.R. Meyer-Fernandes, B. Rossi-Bergmann, R. Coutinho-Silva; Rio de Janeiro, Brazil 264 P4.08.28 - Purinergic receptor functionality controls murine infection by L. amazonensis Vanessa R. Figliuolo da Paz, S.P. Chaves, L.E. Savio, É. Salles, H. Guedes, M.R. D’Império, B. Rossi-Bergmann, R. Coutinho-Silva; Rio de Janeiro, Brazil 265 P4.08.29 - A non-regulated Th1/Th2 inflammatory immune response is linked to clinical problems in congenital toxoplasmosis Yevel Flores-García, R. Figueroa-Damián, I. Cañedo-Solares, D. Correa; Mexico City, Mexico 266 P4.08.30 - Sero-immunoproteomics of Leishmania infantum: a reappraisal of the role of antibodies in protection to the development of kala-azar and antigen discovery for the design of bio-markers and vaccines Luiz G.A. Gardinassi, G.R. Garcia, S.R. Maruyama, F.O. Silva, C.H.N. Costa, R.P. Almeida, A.M.R. Jesus, I.K.F.M. Santos; Ribeirao Preto, Brazil 267 P4.08.31 - Myeloid-derived suppressor cells are key players to balance the exacerbated inflammatory response during acute Trypanosoma cruzi infection A. Arocena, L. Onofrio, A. Paroli, M. Aoki, Susana Gea; Córdoba, Argentina 211 Posters - August 26 268 P4.08.32 - Evaluation of immunological responses against cocktail DNA vaccine of Leishmania major genes in BALB/c mice Fatemeh Ghaffarifar, A. Dalimi, Z. Sharifi, Z.M. Hassan, O. Jorjani, F. Tabatabaie; Tehran, Iran, Islamic Republic of 269 P4.08.33 - Role of arachidonic acid metabolites in Trypanosoma cruzi infection N.A. Guerrero, M. Fresno, Núria Gironès; Madrid, Spain 270 P4.08.34 - Role of B-1 cells in experimental Leshmania amazonensis infection Wagner F.K.M. Gonzaga, M.M. Geraldo, B.C. Vivanco, J.D. Lopes, P. Xander; São Paulo, Brazil 271 P4.08.35 - Identification of Toxoplasma gondii sequences of potential diagnostic value via cDNA library immunoscreening Hossein Hajghani; Kerman, Iran, Islamic Republic of 272 P4.08.36 - Effect of Phlebotomus papatasi saliva extracts on humoral and cellular immune response in individuals living in an endemic area for leishmania major infection Wafa Kammoun Rebai, I. Naouar, A. Toumi, A. Ben Salah, H. Louzir, A. Meddeb-Garnaoui; Tunis, Tunisia 273 P4.08.37 - Cytokine responses & parasite genotypes associated with pathogenesis of human African trypanosomiasis trypanosomiasis in North-eastern Uganda Charles D. Kato, P. Alibu, E. Matovu; Kampala, Uganda 274 P4.08.38 - Induction of protective immune responses against cutaneous leishmaniasis in BALB/c mice by a vaccine containing a new low pathogenic strain of Leishmania major along with imiquimod Vahid Khaze, M. Alimohammadian, S. Ajdary, B. Laamrad, F. Riazi-Rad, H. Darabi, F. Bahrami; Tehran, Iran, Islamic Republic of 275 P4.08.39 - Antiparasitic effects of Foeniculum vulgare extracts against Toxoplasma gondii Fariba Khoshzaban, F. Ghaffarifar; Tehran, Iran, Islamic Republic of 276 P4.08.40 - Serum nitric oxide levels in subjects with high bilirubin value in comparison of normal healthy control subjects Ramesh Kumar; Jhansi, Uttar Pradesh, India 277 P4.08.41 - CD4-CD8- T cells, B cells and complement are critical for resolution of Babesia microti infection in the absence of CD4 Maude Leveque, Z. Silver, C. Wilson, J. Su, S. Telford, J.A. Gelfand, P.J. Krause, E. Vannier; Boston, United States 278 P4.08.42 - Alteration of s-Fas and s-FasL ligand expression during canine visceral leishmaniasis Valéria M. Lima, J. Perosso, S.d. Ferreira, K.L.O. Silva, L.M. Melo; Araçatuba, Brazil 279 P4.08.43 - Phagocytosis of promastigotes of Leishmania amazonensis by B-1 cells M.M. Geraldo, F.M.C. Barbosa, W.F.K.M. Gonzaga, B.C. Vivanco, P. Xander, P. Xander, José D. Lopes; São Paulo, Brazil 280 P4.08.44 - A Mechanistic Insight Into Arabinosylated Lipoarabinomannan (Ara-LAM) Mediated Modulation Of IFN-γ signaling and Different Transcription Factors During Experimental Visceral Leishmaniasis Subrata Majumdar, S. Majumder, B. Paul Chowdhury; Kolkata, India 281 P4.08.45 - Leishmania-induced biphasic ceramide generation in macrophages is crucial for uptake and survival of the parasite Saikat Majumder, R. Dey, S. Bhattacharjee, A. Rub, G. Gupta, S. Bhattacharyya Majumdar, B. Saha, S. Majumdar; Kolkata, India 282 P4.08.46 - Leishmania infantum excreted/secreted proteins impairs differentiation and modulates cytokine production in human dendritic cells and monocytes Wafa Markikou-Ouni, S. Drini, M. Chenik, A. Meddeb-Garnaoui; Institut Pasteur de Tunis, Tunisia 283 P4.08.56 - Excreted/secreted proteins of Leishmania major induce production of IFN-g and granzyme B by CD4+T cells I. Naouar, T. Boussoffara, M. Ben Ahmed, N. Belhaj Hmida, A. Ben Salah, H. Louzir, Wafa Kammoun; Tunis Belvedere, Tunisia 284 P4.08.47 - Leishmania infantum excreted/secreted proteins impairs human dendritic cells differentiation and modulates cytokines production by human dendritic cells and monocytes W. Markikou-Ouni, S. Drini, M. Chenik, A. Meddeb-Garnaoui, Wafa Kammoun; Institut Pasteur de Tunis, Tunisia 285 P4.08.48 - Role of neutrophils in parasite persistence and in host immunity during the initial phase of L. chagasi experimental infection Claudia Marques, S. Falcão, F. Novais, D.M. Santos, A. Rodrigues, F. Passero, D. Mateus, G.M. Santos-Gomes, A. Barral, C.I. de Oliveira; Lisboa, Portugal 286 P4.08.49 - Salivary antigen SP32 is the immunodominant target of the antibody response to Phlebotomus papatasi bites in humans Soumaya Marzouki; Tunis, Tunisia 287 P4.08.50 - Role of P2X7 receptor in the response of phagocytes to Plasmodium chabaudi infection Maria Menezes, É. Salles, A. Cassado, E. Amaral, H. Silva, J. Álvarez, R. Coutinho-Silva, M. D’Império Lima; São Paulo, Brazil 212 Posters - August 26 288 P4.08.51 - Relationship between parasite load and renal lesion in acute experimental Chagas disease Camila B. Miguel, W.F. Rodrigues, J.R.D. Lemos, R.C. Parreira, R.B. Miguel, A.P. Rogério, C.J.F. Oliveira, J.E. Lazo-Chica; Uberaba, Brazil 289 P4.08.52 - Temporal transcriptomic dynamics of human macrophage response to Leishmania major infection Ghada Mkannez, K. Ghedira, F. Guerfali, I. Rabhi, A. Daskalaki, B. Trentin, R. Sghaier, H. Attia, S. Sysco Consortium, O. Collaboraters; Tunis, Tunisia 290 P4.08.53 - MAP kinases activation in macrophages during infection with Neospora caninum Caroline M. Mota, A.M. Oliveira, M.D. Ferreira, F.M. Santiago, P.S.C. Barros, J. Mineo, T.W.P. Mineo; Uberlândia, Brazil 291 P4.08.54 - Seroepidemiology of toxoplasmosis in childbearing women of eastern azarbaijan - iran Mohammad Naghavi - Behzad, A. Naghavi-Behzad, R. Piri, N. Nezami; Tabriz, Iran, Islamic Republic of 292 P4.08.55 - A successful safety trial of gentamicin-attenuated Leishmania infantum vaccine in an endemic area in Southeast of Iran Mohammad J. Namazi, H. Daneshvar, H. Kamyabi; Sabzevar, Iran, Islamic Republic of 293 P4.08.57 - Polymorphisms of cytokines genes associated with ocular toxoplasmosis Carlos Andrés Naranjo, J. Sepúlveda Arias, J. Gómez, A. De la Torre; Pereira, Colombia 294 P4.08.58 - Immunomodulation of Leishmania infection by murine mesenchymal stromal cells in vitro Ana P. Nazario, A.E. Vargas, A.P. Dagnino, P.S. Almeida, E. Engster, P.R.T. Romao; Porto Alegre, Brazil 295 P4.08.59 - Effect of Entamoeba histolytica calreticulin in the immune response of patients with acute amoebic liver abscess Miriam E. Nieves-Ramirez, E. Gonzalez, P. Moran, A. Valadez, M. Garcia, L. Rojas, O. Partida-Rodriguez, E. Hernandez, R. Cerritos, C. Ximenez; Mexico City, Mexico 296 P4.08.60 - Polymorphism of lcr1 gene in different Leishmania species Hamid M. Niknam, F. Firoozeh Abrishami, K. Kiana Fatemi, H. Azimian; Tehran, Iran, Islamic Republic of 297 P4.08.61 - Analysis of the cardiac disorder caused by the intracellular parasite Toxoplasma gondii Kazumi Norose, T. Ishikawa, K.X. Li, T. Ogura, H. Nakaya, M. Furuya, M. Osawa; Chiba, Japan 298 P4.08.62 - Adoptive transfer of Treg (CD4+Foxp3+) cells to B6 mice during Toxoplasma gondii infection induces down-modulation of exacerbated inflammatory immune response but does not generate protection Jonadab E. Olguín, J. Fernández, C. Castellanos, J. Campuzano, N. Salinas, R. Saavedra; Ciudad de México, Mexico 299 P4.08.63 - Natural isotypic response against potential vaccine candidate Plasmodium falciparum Glutamate-Rich Protein (GLURP) in individuals living in Brazilian malaria-endemic area Lilian R. Pratt-Riccio, J.C. Lima-Junior, L.J.M. Carvalho, M. Theisen, F. Santos, J. Oliveira-Ferreira, C.T. Daniel-Ribeiro, D.M. Banic; Rio de Janeiro, Brazil 300 P4.08.64 - Th2-skewed response depends on Insulin-like growth factor I in Leishmania (Leishmania) major-infection Luiza C. Reis, E. Ramos-Sanchez, H. Goto; São Paulo, Brazil 301 P4.08.65 - Modulation of T helper immune response by photodynamic therapy in experimental leishmaniasis Virmondes Rodrigues, P.M. Alves, M.F. Silva, D.M. Souza, S.M.C.F. Carlos, M.V. Silva, T.P. Paulino, D.B.R. Rodrigues; Uberaba, Brazil 302 P4.08.66 - Th17 and Tc17 cells on pregnant women seroposite and seronegative for toxoplasmosis Virmondes J. Rodrigues, J.L.A. Silva, K.R. Oliveira; Uberaba, Brazil 303 P4.08.67 - Inflammatory response of a prostate stromal cell induced by live Trichomonas vaginalis Jae-Sook Ryu, S. Im, N. Gu, M. Ahn; Seoul, Korea, Republic of 304 P4.08.68 - Do different T cell receptor sequences dictate the phenotype of memory CD8 T cells in the Toxoplasma gondii-infected brain? Anna Sanecka, E. Frickel; London, United Kingdom 305 P4.08.69 - Chagas’disease: evaluation of melatonin and lycopene influence on cytokines’profile during acute phase Fabricia H. Santello, M.D. Filipin, V. Brazão, M.A. Toldo, J. do Prado Júnior; Ribeirão Preto, Brazil 306 P4.08.70 - Increased levels of interleukin-4 (IL-4), interleukin-10 (IL-10) and IFN-γ in Iranian Visceral Leishmaniasis (VL) Children Narges Seyfizadeh, Z. Babaloo, M. Bonyadi, N. Seyfizadeh, N. Mirsamadi; Tabriz, Iran, Islamic Republic of 307 P4.08.71 - Infection with Leishmania major induces a cellular stress response in tissue resident macrophages Ana Caroline C. Silva, A.A. Filardy, C.M. Koeller, K.G. Pinto, M. Menezes Passos Diniz, F.L. Ribeiro-Gomes, M.F. Lopes, C.G. Freire-de-Lima, M.P. Nunes, G.A. DosReis; Rio de Janeiro, Brazil 213 Posters - August 26 308 P4.08.72 - Identification of proteins in Leishmania amazonensis extract that may enhance the parasite infection Virgínia M.G. Silva, C.F. Araújo, C.M. Andrade, J.P.C. Cunha, F.K. Marchini, W.L.C. Santos, L.C.P. Carvalho; Jequié, Brazil 309 P4.08.73 - Theileria parva: Genotypic and antigenic diversity in buffalo and buffalo associated- cattle Tatjana Sitt, R. Pelle, L. Steinaa, W. Weir, I. Morrison, P. Toye; Nairobi, Kenya 310 P4.08.74 - Plasma cytokine as biomarker of cardiac morbidity in Chagas disease Giovane R. Sousa, J.A.S. Gomes, R.C.G. Fares, M.P.S. Damásio, A.T. Chaves, N.I. Medeiros, K.S. Ferreira, M.P. Nunes, R. Corrêa-Oliveira, M.O.C. Rocha; Belo Horizonte, Brazil 311 P4.08.75 - A new highly sensible method for division of patients with different forms of Chagas disease according to cytokine production Giovane R. Sousa, J.A.S. Gomes, R.C.G. Fares, M.P.S. Damásio, A.T. Chaves, K.S. Ferreira, N.I. Medeiros, M.P. Nunes, R. Corrêa-Oliveira, M.O.C. Rocha; Belo Horizonte, Brazil 312 P4.08.76 - High IL-17 expression is correlated with better cardiac function in human Chagas disease M.O.C. Rocha, Giovane R. Sousa, R.C.G. Fares, M.P.S. Damásio, A.T. Chaves, K.S. Ferreira, V.A.A. Valente, M.P. Nunes, J.A.S. Gomes, R. Corrêa-Oliveira; Belo Horizonte, Brazil 313 P4.08.77 - The effects of recombinant protein based on Trypanosoma cruzi P21-His6 treatment in infected mice with Leishmania amazonensis C.M. Luise Junior, T.L. Teixeira, F.C. Machado, A.P.N. Quintal, Maria A. Souza, C.V. Silva; Uberlandia, Brazil 314 P4.08.78 - Recombinant human thrombopoietin inhibits the development of murine experimental cerebral malaria by decreasing the inflammatory response Xiaodan Sun, Y. Pan, W. Xu, J. Liu, H. Shang, L. Cui, Y. Cao; Shen Yang, China 315 P4.08.79 - Patients with visceral leishmaniasis present an increased expression of TLR2 and TLR4 in lymphocytes and lipid and protein changes M. Gatto, M.M. Abreu, M.A. Golin, J.C. Simão, Karen I. Tasca, L. Gollino, C.M.C.B. Fortaleza, P.C.M. Pereira, S.A. Calvi; Botucatu, Brazil 316 P4.08.80 - Xanthine oxidase and inducible NOSynthase stress failed to efficiently suppress Leishmania major in BALB/c bone marrow dendritic cells Nabila Tounsi, S. Meghari, M. Moser, B. Djerdjouri; Alger, Algeria 317 P4.08.81 - Leishmania-reactive CD3+CD4-CD8- (Double negative) T cells display functional characteristics of memory T cells and protect against secondary challenge Z. Mou, I. Okwor, D. Liu, Jude E. Uzonna; Winnipeg, Canada 318 P4.08.82 - Molecular characterization T. gondii atypical strains isolated from pregnant women and their neonates in Southern Brazil Rogerio S. Vaz, V.T. Soccol; Curitiba - Paraná, Brazil 319 P4.08.83 - Unusual T. gondii strains associated to congenital toxoplasmosis Rogerio S. Vaz, V.T. Soccol; Curitiba - Paraná, Brazil 320 P4.08.84 - Serological prevalence of Toxoplasma gondii antibodies in pregnant women from Southern Brazil R.S. Vaz, Rogerio S. Vaz; Curitiba - Paraná, Brazil 321 P4.08.85 - Congenital Toxoplasmosis: Current Brazilian public health policy Rogerio S. Vaz; Curitiba - Paraná, Brazil 322 P4.08.86 - Effect of Leishmania mexicana amastigotes in the regulation of L-arginine metabolism in classically and alternatively activated macrophages Arturo A. Wilkins-Rodríguez, A.R. Escalona-Montaño, M. Aguirre-García, L. Gutiérrez-Kobeh; México, D.F., Mexico 323 P4.08.87 - B-1 cells increase susceptibility to murine viscetal leishmaniasis Vanessa Xavier, B.C. Vivanco, W.F.K.M. Gonzaga, C.L. Barbieri, J.D. Lopes, P. Xander; São Paulo, Brazil P4.09 MALARIA PATHOGENESIS AND VACCINES Session Time: Monday, August 26, 13:20 - 15:00 324 214 P4.09.02 - Targeting a Plasmodium vivax merozoite surface protein 1 fragment to the DEC205+ dendritic cell population elicits strong antibody and T cell responses Kelly N.S. Amorim, M.M. Yamamoto, S.B. Boscardin; São Paulo, Brazil Posters - August 26 325 P4.09.03 - T Regulatory cell function in Lethal Plasmodium berghei ANKA and Non-Lethal Plasmodium yoelii infection: Role of Th17 Arindam Bhattacharyya; Kolkata, India 326 P4.09.04 - Systems immunology approach to identify the molecular profile of T cells during Plasmodium mono and mixed infections Julie G. Burel, S.H. Apte, J.M. McCarthy, D.L. Doolan; Brisbane, Australia 327 P4.09.05 - Immunogenicity and efficacy of Plasmodium falciparum MSP3-based immunogens in Saimiri sciureus monkeys C. Bianco-Jr, P.H. Castro, C. Faro, F.A. Alves, P. Druilhe, C.T. Daniel-Ribeiro, Leonardo J.M. Carvalho; Rio de Janeiro, Brazil 328 P4.09.06 - The response of P2X7 deficient and competent immune cells to Plasmodium chabaudi AS infection in chimeric mice Alexandra A. Cassado; São Paulo, Brazil 329 P4.09.07 - CD4+ T cell promote B cell polyclonal activation in an ICOS-dependent manner during Plasmodium chabaudi infection Sheyla I. Castillo-Méndez, S.M. Muxel, E.P. Amaral, C.A. Zago, É. Salles, L.R. Sardinha, N.O. Câmara, E. Faquim-Mauro, J.M. Álvarez, M.R. D´Império Lima; São Paulo, Brazil 330 P4.09.08 - Nitric oxide but not cytokine production by macrophages stimulated with malaria hemozoin is dependent on Nod2 activation Yolanda Corbett, N. Basilico, S. Parapini, S. D’Alessandro, D. Scaccabarozzi, B. Rocca, K. Fitzgerald, D. Golenbock, D. Taramelli; Milan, Italy 331 P4.09.09 - High levels of heme correlate with severe malaria pathology and morbidity in patients from endemic areas in India Esther Dalko, A. Panda, F. Herbert, R. Tripath, B. Ravindran, S. Sharma, B. Das, S. Pied; Lille, France 332 P4.09.11 - Cellular cytokine and chemokine responses associated with susceptibility to severe malaria in children in Papua New Guinea D. Stanisic, J. Cutts, Emily Eriksson, F. Fowkes, J. Taraika, M. Laman, L. Manning, T. Davis, I. Mueller, L. Schofield; Melbourne, Australia 333 P4.09.12 - Sexual hormones are involved in oxidative stress in mice infected with P. berghei ANKA Martha Legorreta-Herrera, N.A. Mosqueda-Romo; México, Mexico 334 P4.09.13 - Blood group O protects against complicated Plasmodium falciparum malaria by the mechanism of inducing high levels of anti-malarial IgG antibodies Amre Nasr, M. Eltoum, A. Yassin, G. ElGhazali; Khartoum, Sudan 335 P4.09.14 - Targeting the Plasmodium chabaudi MSP1(19) protein to the DEC205 dendritic cell population induces faster parasite clearence Raquel H. Panatieri, H.B. da Silva, M.M. Yamamoto, M. D’Imperio Lima, S.B. Boscardin; Sao Paulo, Brazil 336 P4.09.15 - Placental lesions as result of TLR4 activation by Plasmodium berghei are associated with low birth weight Aramys S. Reis, R. Barboza, S.B. Boscardin, S. Epiphanio, C.R.F. Marinho; São Paulo, Brazil 337 P4.09.16 - The P2X7 receptor contributes to protection and to ameliorate the clinical manifestations of blood-stage Plasmodium chabaudi malaria Érika M. Salles, M. Menezes, A. Cassado, E. Amaral, S. Castillo-Mendez, H. Silva, J. Alvarez, R. Coutinho-Silva, M. D’Império-Lima; São Paulo, Brazil 338 P4.09.17 - Polygenic control of human antibody responses to synthetic malaria vaccine Osvaldo A. Sant’Anna, M.V. Valero, A.G. Trezena, J. Kalil, M.E. Patarroyo; São Paulo, Brazil 339 P4.09.18 - Inflammatory factors and leucocytes are involved in the pathogenesis of malaria associated acute lung injury/acute respiratory distress syndrome in murine model Michelle K. Sercundes, L.d. Ortolan, D. Debone, E.H. Aitken, M. Russo, J.M. Alvarez, C.R.F. Marinho, S. Epiphanio; Sao Paulo, Brazil 340 P4.09.19 - Extracellular ATP accelerates malaria anemia Kazutomo Suzue, M. Nishimori, M. Hirai, T. Imai, T. Taniguchi, H. Okada, C. Shimokawa, S. Koyasu, H. Hisaeda; Maebashi, Gunma, Japan 341 P4.09.20 - The role of P2X7 receptor in hepatic necrosis caused by Plasmodium chabaudi AS infection Flavia Sarmento Vieira, A. Freitas do Rosario, M. D’Imperio Lima; Sao Paulo, Brazil 342 P4.09.21 - S-nitrosoglutathione prevents experimental cerebral malaria Graziela M. Zanini, Y.C. Martins, P. Cabrales, J.A. Frangos, L.J.M. Carvalho; Rio de Janeiro, Brazil 343 P4.09.22 - Pys48 and Pys25 DNA Vaccine supplement medicated the inhibitory development of Plasmodium yoelii gametocytes into gametes Li Zheng, Y. Cao; Shenyang, China 215 Posters - August 26 P5.18 INFLAMMATORY BOWEL DISEASES Session Time: Monday, August 26, 13:20 - 15:00 344 P5.18.01 - Modulation of macrophage differentiation by crotoxin from Crotalus durissus terrificus in acute intestinal inflammation in mice Caroline S. Almeida, J. Jacysyn, E.L. Faquim-Mauro; São Paulo, Brazil 345 P5.18.02 - The role of IFITM genes in the pathogenesis of the gastro-intestinal tract Zoya Alteber, E. Tzehoval, L. Eisenbach; Rehovot, Israel 346 P5.18.03 - Profile of ANCA (Anti-Neutrophil Cytoplasmic Antibodies) and ASCA (Anti-Saccharomyces Cerevisiae mannan Antibodies) in patients with IBD (Inflammatory Bowel Diseases): Crohn’s disease and Ulcerative Colitis Siham Aziz, N. Tahiri Jouti, W. Badre, A. Naya, Z. Serhier, R. Alaoui, S. Zamiati; Casablanca, Morocco 347 P5.18.04 - Glucocorticoid-induced leucine zipper (GILZ) regulates intestinal immune homeostasis and anti-inflammatory effects of glucocorticoids Oxana Bereshchenko, M. Coppo, M. Biagioli, T. Frammartino, M. Cimino, A. Venanzi, D. Sorcini, M. Di Sante, S. Bruscoli, C. Riccardi; Perugia, Italy 348 P5.18.05 - Polymorphisms of NOD2/CARD15 and PTPN22 in Algerian adult inflammatory bowel disease (IBD) Aziza Boukercha, A. Bouzidi, H. Saoula, F. Chemandji, M. Nakmouche, C. Touil-Boukoffa, H. Mesbah-Amroun; Algiers, Algeria 349 P5.18.06 - Autoimmune diseases association study with the KIAA1109-IL2-IL21region in a Tunisian population D. Bouzid, H. Fourati, A. Amouri, I. Marques, Olfa Abida, N. Tahri, C. Penha-Gonçalves, H. Masmoudi; Sfax, Tunisia 350 P5.18.07 - Frequency of NOD2/CARD15 and MDR1 gene polymorphisms in a cohort of Algerian pediatric Crohn’s disease patients Amira Bouzidi, A. Boukercha, F. Benhassine, W. Messadi, C. Touil-Boukoffa, H. Mesbah-Amroun; Algiers, Algeria 351 P5.18.08 - miR-132/212 cluster knockout ameliorated DSS-induced colitis Ichino Chinen, T. Nakahama, N.T. Nguyen, D. Millrine, S. Lee, T. Kishimoto; Suita, Japan 352 P5.18.09 - Overexpression of IL-9 and its receptor in Crohn’s disease Mircea T. Chiriac, N. Nalleweg, G. Hundorfean, M.F. Neurath, J. Mudter; Erlangen, Germany 353 P5.18.10 - Integrity of the splenic nerve is required to mediate the vagal anti-inflammatory effect on colonic inflammation in a murine DSS-induced model of colitis Léa M.M. Costes, B.J. Olivier, J. van der Vliet, W.J. de Jonge, G.E. Boeckxstaens, C. Cailotto; Amsterdam, Netherlands 354 P5.18.11 - Neutrophil gelatinase B-associated lipocalin - matrix metalloproteinase-9 (NGAL-MMP-9) complex as a surrogate serum marker for mucosal healing in ulcerative colitis Magali de Bruyn, I. Arijs, W. Wollants, K. Machiels, K. Van Steen, M. Ferrante, S. Vermeire, P. Rutgeerts, G. Opdenakker; Leuven, Belgium 355 P5.18.12 - Rip-2 mediated control of pathogenic and protective T cell function during chronic colitis Nichole K. Escalante, M. Cruz Tleugabulova, D. Philpott, T. Mallevaey; Toronto, Canada 356 P5.18.13 - Significance of IL-9 levels in inflammatory bowel disease C. Defendenti, Atzeni Fabiola, S. Saibeni, S. Bollani, S. Bruno, P. Almasio, P. Sarzi-Puttini; Milan, Italy 357 P5.18.15 - Vanin-1 (VNN1), an epithelial pantetheinase that regulates intestinal inflammation Thomas Gensollen, C. Bourges, F. Galland, P. Naquet; Marseille, France 358 P5.18.16 - Assessment of loss of response to Infliximab therapy in inflammatory bowel diseases using antibodies to Infliximab and trough Levels Luisa Guidi, M. Marzo, G. Andrisani, A. Papa, C. Felice, D. Pugliese, S. Canestri, B. Tolusso, E. Gremese, A. Armuzzi; Rome, Italy 359 P5.18.17 - Mannose receptor contributes to intestinal inflammation Sigrid E.M. Heinsbroek, R. Schilderink, A.A. te Velde, S. Gordon, W.J. de Jonge; Amsterdam, Netherlands 360 P5.18.18 - Microscopic colitis patients demonstrate a mixed Th17/Tc17 and Th1/Tc1 mucosal cytokine profile Ashok K. Kumawat, H. Strid, C. Tysk, J. Bohr, E. Hultgren Hörnquist; Orebro, Sweden 361 P5.18.19 - Involvement of mast cells in the development of colitis-associated colon cancer Young-Mi Lee, M. Xin, D. Kim; Iksan, Korea, Republic of 362 P5.18.20 - Whey and Soy protein supplements improves body composition in patients with Crohn`s disease under azathioprine and anti-TNF- α therapy Júlia F. Machado, V. Oya, C.S.R. Coy, A.M. Morcillo, M.M.S. Vilela; Campinas, Brazil 216 Posters - August 26 363 P5.18.21 - The role of FIBCD1 in intestinal homeostasis and inflammation Jesper B. Moeller, A. Schlosser, T. Bak-Thomsen, M. Hammond, L. Dubey, O. Nielsen, G.L. Sorensen, U. Holmskov; Odense C, Denmark 364 P5.18.22 - Protective role of HLADRB1*04 allele against ulcerative colitis in Iran Mojgan Mohammadi, M.M. Hayatbakhsh, H. Abdoli Sereshki, M.J. Zahedi, H. Rafatpanah, M. Rastin, A.R. Nicpoor; Kerman, Iran, Islamic Republic of 365 P5.18.23 - SHIP represses auto-inflammation and is required for intestinal immune homeostasis Eyler N. Ngoh, S.B. Weisser, H. Brugger, R. Jen, A. Hirschfeld, S. Turvey, L.M. Sly; Vancouver, Canada 366 P5.18.24 - Multispecific anti-neutrophil cytoplasmic antibodies in chronic inflammatory bowel diseases: what does that mean? Branka Nikolic, M. Nikolic, S. Dobric, D. Popovic, S. Andrejevic; Belgrade, Serbia 367 P5.18.25 - Phenotypic and functional characterization of intraepithelial and lamina propria inflammatory cell infiltrate in autoimmune enteropathy Moira Paroni, G. Nizzoli, A. Magarotto, U. Gianelli, C. Ciafardini, D. Conte, S. Abrignani, J. Geginat, F. Caprioli; Milan, Italy 368 P5.18.26 - Decrypting the role of S1P/SphK axis in the dextran sulphate sodium-mediated colitis in mice Peter N. Pushparaj, L.A. Damiati, S.D. Kumar, K. Gauthaman, J. Manikandan, M.H. Al-Qahtani; Jeddah, Saudi Arabia 369 P5.18.27 - Systems immunological strategies to decipher the genomic expression patterns in dextran sulphate sodium-mediated acute colitis Peter N. Pushparaj, L.A. Damiati, J. Manikandan, K. Gauthaman, M.H. Al-Qahtani; Jeddah, Saudi Arabia 370 P5.18.28 - Dissecting the effect of resveratrol in dextran sulphate sodium-mediated colitis in Balb/c mice Peter N. Pushparaj, S.D. Kumar, L.A. Damiati, J. Manikandan, K. Gauthaman, M.H. Al-Qahtani; Jeddah, Saudi Arabia 371 P5.18.29 - TL1A/DR3 interaction is associated with pathogenesis of inflammatory bowel disease in adults and children Tomasz J. Slebioda, P.M. Wierzbicki, M. Stanislawowski, K. Celinski, P. Landowski, B. Kaminska, A. Bojarska-Junak, J. Rolinski, K. Adrych, Z. Kmiec; Gdansk, Poland 372 P5.18.30 - Anti-TNF-alpha monoclonal antibody therapy of crohn’s disease is associated with acute reduction of circulating classical and intermediate monocyte numbers Stephanie M. Slevin, C. Dennedy, A. Ribeiro, R. Ceredig, M.D. Griffin, L.J. Egan; Galway, Ireland 373 P5.18.31 - A crude extract of hydatid laminated layer prevents Dextran Sulfate Sodium induced-colitis in mice by Nitric Oxide Synthase2 down-regulation Imene Soufli, H. Rafa, M. Amri, R. Toumi, K. Abdelouhab, C. Touil-Boukoffa; Algiers, Algeria 374 P5.18.32 - Transfer of Myeloid Derived Suppressor Cells from neonatal tolerized IL-10 gene-deficient mice protects from development of intestinal inflammation Beate C. Sydora, E.J. Albert, R.R. Foshaug, B.S. Sydora, R.N. Fedorak; Edmonton, Canada 375 P5.18.33 - Infiximab Simultaneously Restore Foxp3+Treg, Type 1-Like Treg and B cells in IBD Z. Li, S. Vermeire, D. Bullens, M. Ferrante, K. Van Steen, M. Noman, P. Rutgeerts, J. L. Ceuppens, Gert Van Assche; Leuven, Belgium 376 P5.18.34 - BCG-specific lymphocyte proliferation and cytokine in patients with Crohn`s disease under anti-TNF- α and azathioprine therapy. V. Oya, T. Davanço, C.S.R. Coy, M.T.N. da Silva, T.N. Mazzola, A.M. Morcillo, E.L.C. Pinto, Maria M.S. Vilela; Campinas, São Paulo, Brazil 377 P5.18.35 - Prevalence of IgA anti-zein antibodies in Mexican patients with celiac disease (CD) and irritable bowel syndrome (IBS) L.A. Sanchez-Vargas, J.M. Remes-Troche, G. Mellado-Sanchez, E. Bravo-Sarmiento, Hector Vivanco-Cid; Veracruz, Veracruz, Mexico 378 P5.18.36 - NDST4 deficiency enhances acute colitis and colitis-associated tumorigenesis in mice C.Y. Huang, M.H. Tsai, T.M. Jao, S.T. Tzeng, J.X. Lee, W.C. Lo, C.W. Chang, Y.L. Li, Ya C. Yang; Taipei, Taiwan P5.19 REPRODUCTIVE IMMUNOLOGY Session Time: Monday, August 26, 13:20 - 15:00 379 P5.19.01 - HLA antigens and anti-sperm antibody Gholamreza Azizi, A. Mirshafiey, M. Eslami, S. Namaki; Karaj, Iran, Islamic Republic of 380 P5.19.02 - Multiple immune accentuations predict implantation failure and mark target group among IVF patients for intravenous immunoglobulin therapy Viktor Chernyshov, I. Sudoma, B. Dons’koi, Y. Goncharova; Kiev, Ukraine 217 Posters - August 26 381 P5.19.03 - Features of the immune response and microbial colonization in children with extremely low birth weight Guzel Chistyakova; Yekaterinburg, Russian Federation 382 P5.19.04 - Maternal-fetal immunotolerance from mice with pregnancy loss induced by adoptively transferring exosomes from T lymphocytes Cheng Cui, S. Hao, Y. Wang, M. Li, W. Lv; Shijiazhuang, China 383 P5.19.05 - The predominance of Th17 lymphocytes and decreased number and function of Treg cells are present in preeclampsia Dorota A. Darmochwal-Kolarz, M. Kludka-Sternik, B. Kolarz, J. Rolinski, J. Oleszczuk; Lublin, Poland 384 P5.19.06 - Effect of prenatal steroid treatment on the developing immune system Ines Dipenbruck, C.C. Much, A. Krumholz, R. Thieme, D. Thieme, M. Solano, P.C. Arck, E. Tolosa; Hamburg, Germany 385 P5.19.07 - HLA-G6 and reproductive immunology Faramarz Farzad, S. Abediankenari, I. Naghavian; Sari, Iran, Islamic Republic of 386 P5.19.08 - Automated clustering of flow cytometry data identifies a Th0 population induced by influenza vaccination in pregnant women Dzhamala Gilmandyar, D. Roumanes, J. Rebhahn, L. Thornburg, T.R. Mosmann; Rochester, United States 387 P5.19.09 - Inflammation as a cause of placental dysfunction in high-risk pregnancies Sylvie Girard, A.E.P. Heazell, H. Derricott, C.P. Sibley, S.M. Allan, R.L. Jones; Manchester, United Kingdom 388 P5.19.10 - Inhibition of TLR3 mediated direct natural killer cell activation by a macrolide antibiotic clarithromycin N. Hirohata, S. Komine-Aizawa, Satoshi Hayakawa; Tokyo, Japan 389 P5.19.11 - The export of T helper cells from thymus during pregnancy Sandra Hellberg, R.B. Mehta, M. Edström, A. Forsberg, G. Berg, O. Winqvist, M.C. Jenmalm, J. Ernerudh; Linköping, Sweden 390 P5.19.12 - Expression of LAG-3, but not PD-1, is enriched on double negative T cells at the female genital tract Jennifer Juno, J. Lajoie, C. Wachihi, M. Kimani, J. Kimani, F. Plummer, K. Fowke; Winnipeg, Canada 391 P5.19.13 - Reduced inhibitory NK cell receptors expression in women with recurrent spontaneous abortions (RSA) Vasiliki Kitsiou, S. Dendrinos, K. Psarra, E. Konsta, E. Grigoriou, G. Kreatsas, C. Papasteriades; Athens, Greece 392 P5.19.14 - Lipid bodies in preimplantation embryo health Christiana Kyvelidou, G.J. Tserevelakis, G. Filippidis, C. Fotakis, I. Athanassakis; Heraklion, Greece 393 P5.19.15 - Influence of THP-1 cells on endothelial cells tube formation in the presence of soluble placenta-derived factors Tatiana Y. Lvova, O.I. Stepanova, K.N. Furaeva, E.A. Potolicina, D.A. Korenkov, S.A. Selkov, D.I. Sokolov; Saint-Petersburg, Russian Federation 394 P5.19.17 - Effect of high-dose dexamethasone in early pregnancy on pregnancy outcome Hasan Namdar Ahmadabad, S. Moazzeni, M. Salehnia; Tehran, Iran, Islamic Republic of 395 P5.19.18 - Genetic polymorphisms of KIR2DL4 and LILRB1 in spontaneous abortion and control women in Polish population Izabela Nowak, E. Barcz, A. Malinowski, J. Wilczynski, M. Banasik, E. Majorczyk, P. Kusnierczyk; Wrocław, Poland 396 P5.19.19 - Potential role of circulating microRNAs as a biomarker for unexplained recurrent spontaneous abortion Weibing Qin, N. Yang, Y. Wang, Z. Miao, R. Cui, X. Wang; Guangzhou, China 397 P5.19.20 - Pro-inflammatory and anti-inflammatory cytokine production patterns in intra-uterine growth restriction (IUGR) Raj Raghupathy, M. Al-Azemi Majedah, F. Azizieh; Faculty of Medicine, Kuwait 398 P5.19.21 - Trophoblast cells induce and recruit iTregs by VIP production and through a TGF beta dependent pathway L. Fraccaroli, E. Grasso, V. Hauk, G. Mor, C. Perez-Leiros, Rosanna Ramhorst; Buenos Aires, Argentina 399 P5.19.22 - CD4(+) CD25(high) Foxp3(+) cells increased in the peritoneal fluid of patients with endometriosis Luiz V. Rizzo, S. Podgaec, L.F. Cordeiro Fernandes, E. Chada Baracat, M. Simoes Abrao; Sao Paulo, Brazil 400 P5.19.23 - Immune profile of Sudanese women with conception disorders: Possible role for T-helper cytokines Habab M.A. Saad; Khartoum, Sudan 401 P5.19.24 - Intravenous immunoglobulin treatment on expanded CD56+ cells in women with recurrent reproductive failure R. Ramos-Medina, A. Garcia-Segovia, A. Aguraron de la Cruz, J. Gil, J. Carbone, A. Seyfferth, J. Alonso, L. Ortiz-Quintana, E. Fernandez-Cruz, Silvia Sanchez-Ramon; Madrid, Spain 218 Posters - August 26 402 P5.19.25 - Expression profiling of vitamin D receptor in reproductive tissues of pregnant mice Mehdi Shabazi, A.h. Zarnani; Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of 403 P5.19.26 - Immune cells functional disorder in case of preeclampsia Dmitry Sokolov, Y. Onohina, V. Mikhaylova, O. Ovchinnikova, D. Korenkov, S. Selkov; St.Petersburg, Russian Federation 404 P5.19.27 - Influence of placental secretory factors to endothelial cell and monocyte phenotype and monocyte transendothelial migration activity Olga I. Stepanova, T. Lvova, K. Furaeva, E. Rebezova, A. Baldin, D. Sokolov, S. Selkov; Saint Petersburg, Russian Federation 405 P5.19.28 - Parameters of cellular immunity in pregnant women with threatened abortion in early pregnancy, against the low level of progesterone Iryna I. Voronova, T.N. Demina; Donetsk, Ukraine 406 P5.19.29 - Polymorphisms -725 C>G>T, -716 T>G of the HLA-G gene in spontaneous abortion and control women in Polish population Marta Wagner, I. Nowak, E. Barcz, A. Malinowski, J. Wilczynski, M. Banasik, A. Wisniewski, E. Wisniewska, P. Kusnierczyk; Wroclaw, Poland 407 P5.19.30 - Spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin A4 axis Jie Zhao, X.Z. Ye, Z.H. Feng; Wuhan, China 408 P5.19.31 - The role of systemic inflammation in the development of pregnancy and obstetric complications Iuliia Zhuravleva, L. Solomatina, A. Brazhnikov, E. Gusev; Ekaterinburg, Russian Federation P5.20 TUMOR IMMUNITY AND IMMUNOSURVEILLANCE Session Time: Monday, August 26, 13:20 - 15:00 409 P5.20.001 - Anti-tumor specific T-helper cell priming by CIITA-driven MHC-II-positive tumor cells in dendritic cell-depleted transgenic mice L. Lombardo, G. Forlani, A. Tedeschi, Roberto S. Accolla; Varese, Italy 410 P5.20.002 - Domination of Th17 subpopulation of lymphocytes during tumor progression Maryam Ajami, R. Mansouri, J. Hadjati; Tehran, Iran, Islamic Republic of 411 P5.20.003 - Relation between Hepatitis B virus DNA load and quantitative HBsAg in HBV infected patient’s sera Sohrab Alam, A. Afrin, A. Hye, S.K. Saha, S. Choudhury, S.A. Khan, Z.F. Rahman, M. Hossain, M.S. Hassan, I. Mahmud; Dhaka, Bangladesh 412 P5.20.004 - BRCA1 gene deletions and duplications in Omani Breast cancer cases Aliya Alansari, K. Al-Mawali, B. Al-Bahrani, M. Al-Moundhri; Al-Khoud, Oman 413 P5.20.005 - Interplay of Th17/Treg cells in immunopathogenesis of Urothelial carcinoma of bladder Vivek Anand, S. Chugh, L. Swaroop, A. Seth, A. Sharma; New Delhi, India 414 P5.20.006 - Association some of the major histocombatibility complex class II alleles with breast cancer among Jordanian females Manar F. Atoum, R.Q. Tanashat; Zarqa, Jordan 415 P5.20.007 - Expression of CD95 and caspases activity in peripheral blood lymphocytes during breast cancer development Uliana S. Bagina, K.S. Ignatyev, P.I. Kovchur, I.E. Bahlaev, T.O. Volkova; Petrozavodsk, Russian Federation 416 P5.20.008 - Serum Amyloid A impacts the growth of melanoma cells and may be a link between inflammation and cancer outcome Luziane P. Bellé, F.H. Knebel, R.C. Albuquerque, S.S. Maria-Engler, A. Campa; Sao Paulo, Brazil 417 P5.20.009 - A relationship between soluble MICA and anti-MICA-Abs in nasophayngeal carcinoma patients Arij Ben Chaaben, H. Abaza, H. Douik, T. Mamoghli, G. Kablouti, L. Harzallah, S. Gritli, D. Charron, F. Guemira, R. Tamouza; Tunis, Tunisia 418 P5.20.010 - Tertiary lymphoid tissue (TLT) in colorectal cancer: lymph node-like aggregates supporting the immune response Francesca Bergomas, G. Di Caro, F. Grizzi, A. Doni, P. Bianchi, A. Malesci, L. Laghi, P. Allavena, A. Mantovani, F. Marchesi; Rozzano (MI), Italy 419 P5.20.011 - Role of ATP and myeloid derived suppressor cells in neuroblastoma microenvironment Giovanna Bianchi, P. Pellegatti, D. Marimpietri, L. Emionite, I. Marigo, M. Cilli, F. Di Virgilio, V. Bronte, V. Pistoia, L. Raffaghello; Genoa, Italy 420 P5.20.012 - Antitumor activity of synthetic phosphoethanolamine in experimental melanoma L.C. Veronez, T.H. Geraldino, C.D. Polli, L.R. Azevedo, D.O. Miranda, R.O. Lopes, D.A. Maria, S.B. Garcia, Gabriela S. Bisson; Ribeirão Preto, Brazil 219 Posters - August 26 421 P5.20.013 - Proteomic identification of Annexin A4 as a novel renal cell carcinoma associated antigen Apollinariya V. Bogolyubova, C. Gouttefangeas, D.J. Kowalewski, A.T. Kopylov, A. Stenzl, S.A. Nedospasov, P.V. Belousov; Moscow, Russian Federation 422 P5.20.014 - Proliferative potential of double positive CD4+/CD8+ T lymphocytes in coculture with tumor cells Florina M. Bojin, L. Cernescu, A. Cean, G. Tanasie, C. Panaitescu, V. Paunescu; Timisoara, Romania 423 P5.20.015 - Cis-acting genetic elements at or near the Pas1 locus control Kras2 mutations and gene expression in lung tumors from mice selected for acute inflammatory response Andrea Borrego, A. Galvan, J.R. Jensen, W. Cabrera, O.G. Ribeiro, N. Starobinas, M. De Franco, O.M. Ibañez, G. Manenti, T.A. Dragani; São Paulo, Brazil 424 P5.20.016 - Inhibition of cell cycle progression and apoptotic activity of Ganoderma lucidum in oral cancer cell lines Marinela Bostan, M. Mihaila, G. Matei, L. Brasoveanu; Bucharest, Romania 425 P5.20.017 - Urethane-induced lung cancer and associated events D. Teixeira, G.N. Gomes, A.E. Hirata, Valquiria Bueno; São Paulo, Brazil 426 P5.20.018 - SIGIRR as a novel HER2-Regulated gene in breast tumors Luis Felipe I. Campesato, A.M. Silva, F.C.P. Navarro, M. Marçola, R.P. Markus, A. Lepique, E.T. Costa, A.A. Camargo; São Paulo, Brazil 427 P5.20.019 - ANGPTL4 is involved in the metastatic hepatoma cells’ survival in the third microenvironment Lili Cao, L. Han, Z. Zhang, W. Sun; Jinan, China 428 P5.20.020 - Identification of Early Pancreatic Cancer-Associated Autoantibodies in Mouse and Human Michela Capello, S. Ferri-Borgogno, P. Cappello, W. Zhou, G. Mandili, I. Sperduti, F.C. Linty, G. Maruccio, M. Milella, F. Novelli; Turin, Italy 429 P5.20.021 - CD4+CD25highFoxP3+ regulatory T lymphocytes in peripheral blood of gastric cancer patients during chemoradiotherapy Agata Chwieduk, A. Gdowicz-Kłosok, A. Namysł-Kaletka, P. Polanowski, R. Kawczynski, J. Wydmanski; Gliwice, Poland 430 P5.20.022 - Dendritic cells from mesothelioma patients are numerically and functionally impaired Scott M. Cornwall, M. Wikstrom, A. Nowak, J. Alvarez, D. Nelson; Bentley, Australia 431 P5.20.023 - High proportion of PMN-MDSCs within primary tumors correlates with disease aggressiveness in melanoma Laetitia Douguet, A. Pommier, R. Lengagne, M. Avril, B. Lucas, A. Prevost Blondel; Paris, France 432 P5.20.024 - IL-18-Binding Protein (BP) is expressed in human ovarian cancer and may limit IL-18 activity Silvano Ferrini, G. Carbotti, M. Fabbi, A. Orengo, A. Brizzolara, G. Barisione, D. Mezzanzanica, P. Pinciroli, M. Bagnoli, I. Airoldi; Genoa, Italy 433 P5.20.025 - Proteolytic machinery involved in MICA and MICB processing in cervical Cancer Mariel Garcia-Chagollan, M.R. Bueno-Topete, S. Fujimura-Hernandez, R.A. Franco-Topete, B.E. Bastidas Ramirez, M. Fafutis-Morris, S. del Toro-Arreola; Guadalajara, Mexico 434 P5.20.026 - Analysis of lymphocyte subpopulations in blood from gastric cancer patients during radiotherapy Agnieszka Gdowicz-Klosok, A. Chwieduk, A. Namysł-Kaletka, R. Kawczynski, P. Polanowski, J. Wydmanski; Gliwice, Poland 435 P5.20.027 - Involvement of the long pentraxin PTX3 in skin carcinogenesis Stefania Gentile, E. Bonavita, N. Polentarutti, F. Pasqualini, F. Feruglio, S. Tartari, M. Nebuloni, T. Schioppa, A. Mantovani, C. Garlanda; Rozzano, Italy 436 P5.20.028 - Intra-tumoral B cells are able to organize into tertiary lymphoid structures and to develop a protective humoral immune response in lung cancer patients Claire Germain, F. Tamzalit, S. Knockaert, S. Gnjatic, P. Validire, R. Remark, D. Damotte, W.H. Fridman, C. Sautes-Fridman, M.C. Dieu-Nosjean; Paris, France 437 P5.20.030 - The heterogeneity of lung metastasis immune microenvironment according to the primary tumor location Nicolas A. Giraldo, R. Remark, A. Lupo, D. Damotte, M. Alifano, I. Cremer, M.C. Dieu-Nosjean, C. Sautès-Fridman, W.H. Fridman; Paris, France 438 P5.20.031 - Azacytidine and Everolimus therapy reduces the high frequency of terminally differentiated CD38+HLADR- CD8 T cells in relapsed AML patients Chindu Govindaraj, P. Tan, P. Walker, A. Spencer, A. Wei, M. Plebanski; Melbourne, Australia 439 P5.20.032 - Panobinostat in combination with azacitidine reduces the frequency of TNFR2+ Tregs in newly diagnosed acute myeloid leukemia patients Chindu Govindaraj, P. Tan, P. Walker, A. Wei, A. Spencer, M. Plebanski; Melbourne, Australia 440 P5.20.033 - The effects of Cancer Associated Fibroblasts on mechanisms of immune evasion in a rat chemical mammary carcinoma model Gurcan Gunaydin, Y. Dolen, N. Unver, S. Kesikli, D. Guc; Ankara, Turkey 220 Posters - August 26 441 P5.20.034 - Effects of Silymarin on frequency and function of Myeloid-derived suppressor cells in animal model of tumor Morteza Hafezi, A. Namdar, N. Khosravianfar, A. Razavi, J. Hadjati; Tehran, Iran, Islamic Republic of 442 P5.20.035 - Formation of vascular mimicry in human gastric cancer and the corelation with LOX and MMP-9 Mei Han, Y. Cao, H. Sun, R. Bai; Yinchuan, China 443 P5.20.036 - Aberrant expression of circulating PD-L1+CD14+HLA-DR-/low cells in esophageal squamous cell carcinoma patients: Immunosuppressive characteristics and tumor clinical relevance Haitao Huang, G. Zhang, G. Li, H. Ma, X. Zhang; Suzhou, China 444 P5.20.037 - Microparticles: a road to antitumor immunity Bo Huang; Beijing, China 445 P5.20.038 - Mapping on chromosome 17 a novel major locus determining kidney cancer susceptibility in mice J.R. Jensen, A. Galvan, M. Colecchia, W.H.K. Cabrera, O.G. Ribeiro, N. Starobinas, A. Borrego, M. De Franco, T.A. Dragani, Olga M. Ibañez; São Paulo, Brazil 446 P5.20.039 - Anti-tumor effect of BCG-LM via activated eosinophils. Toshihiro Ito, I. Yano, T. Nakayama; Chiba, Japan 447 P5.20.040 - Inducible nitric oxide synthase from prostate cancer stem/initiating cells inhibits T cell priming Elena Jachetti, M. Grioni, S. Mazzoleni, C. Brambillasca, R. Galli, M. Bellone; Milan, Italy 448 P5.20.041 - Inflammatory stress upregulates chemokine expression in uveal melanoma cell lines and increases monocyte migration Tina Jehs, H.B. Juel, C. Faber, I.H.G. Bronkhorst, M.J. Jager, M.H. Nissen; Copenhagen, Denmark 449 P5.20.042 - Interleukin-33/ST2 Axis Promotes Breast Cancer Progression and Angiogenesis by Intratumoural Accumulation of Immunosuppressive and Natural Helper Cells Ivan Jovanovic, N. Pejnovic, G. Radosavljevic, J. Pantic, M. Milovanovic, N. Arsenijevic, M. Lukic; Kragujevac, Serbia 450 P5.20.043 - The role of memory T lymphocytes during growth of SL2 tumours in DBA/2 mice Jurgita Jursenaite, I. Girkontaite, M. Mauricas, D. Characiejus; Vilnius, Lithuania 451 P5.20.044 - Myeloma with biclonal IgG lambda and IgD kappa in serum : a case report Sana Khlif, H. Hachicha, S. Ben jemaa, S. Feki, M. Medhaffer, M. Ben Ayed, S. Baklouti, M. Elloumi, H. Masmoudi; Sfax, Tunisia 452 P5.20.045 - Effect of SAA1, SAA2 and SAA4 knockdown on proliferation and invasion of glioblastomas multiformes cells Franciele H. Knebel, L.P. Bellé, R.B. Haga, G.H. Kaihami, A. Campa; São Paulo, Brazil 453 P5.20.046 - Inactivation of tumor-specific CD8+ CTLs within tumor-infiltrating lymphocytes by tumor-infiltrating immunosuppressive tolerogenic dendritic cells Hideki Kogo, H. Harimoto, M. Shimizu, T. Date, Y. Nakagawa, K. Nakatsuka, A. Wakabayashi, C. Sakamoto, E. Uchida, H. Takahashi; Tokyo, Japan 454 P5.20.047 - Systemic changes of cellular immune parameters as observed in patients with preinvasive/invasive cervical cancer before and after treatment Olga V. Kurmyshkina, P.I. Kovchur, I.E. Bakhlaev, T.O. Volkova, A.N. Poltorak; Petrozavodsk, Russian Federation 455 P5.20.048 - Repurposing Na+/K+ pump blockers for in vitro suppression of tumor development Radu Lazarovicz, M. Toma, O. Gavriliuc, L. Marusciac, A. Gruia, C. Tatu, G. Tanasie, C. Panaitescu, F. Bojin, V. Paunescu; Timisoara, Romania 456 P5.20.049 - Down-regulation of EMT signal and invasive properties of colon cancer cells by SOCS1 Choong-Eun Lee, W. Kim, S. Ahn, B. Yoo; Suwon, Korea, Republic of 457 P5.20.050 - B7-H4 modulates anti-tumor responses by limiting immunosuppression in the tumor microenvironment Joanne Leung, W. Suh; Montreal, Canada 458 P5.20.051 - DcR3 gene polymorphisms are associated with sporadic breast infiltrating ductal carcinoma in chinese northeast women:a case control study Z. Fu, D. Li, S. Chen, Dianjun Li; Harbin, China 459 P5.20.052 - HVEM gene polymorphisms are associated with sporadic breast cancer in Chinese women Dianjun Li, D. Li, Z. Fu, S. Chen; Harbin, China 460 P5.20.053 - Association of LTBR gene polymorphisms with sporadic infiltrative duct carcinoma in northeast Chinese Han population S. Chen, W. Yuan, Z. Fu, Dianjun Li; Harbin, China 221 Posters - August 26 461 P5.20.054 - Association Analysis between HLA-DRB1 Allelic Polymorphisms and Age to Identify Genes Promoting the Early Onset of Solid Cancers Hui Liu; Dalian, China 462 P5.20.055 - HLA-E is expressed and functional in melanoma but not melanocytes Elisa Lo Monaco, E. Tremante, P.G. Natali, M. Mottolese, P. Visca, M. Benevolo, P. Giacomini; Roma, Italy 463 P5.20.056 - Dendritic cell density and HMGB1 expression in non-small cell lung carcinomas Jose S. Lopez-Gonzalez, D. Aguilar-Cazares, M. Meneses-Flores, H. Prado-Garcia, V. Rojo-Leon, L. Islas-Vazquez; Mexico city, Mexico 464 P5.20.057 - Studies on immunogenetic mechanism of hepatocellular carcinoma caused by Fas gene polymorphism Haiting Mao, J. Zhang, Y. Yang, J. Sun, C. Ma, W. Gao, B. Song, Q. Shao, X. Qu; Jinan, China 465 P5.20.058 - Identification and characterization of candidate MDSCs in PBMCs of patients with lymphoproliferative malignancies Olivia Marini, M.A. Cassatella, G. Pizzolo, P. Scapini, C. Tecchio; Verona, Italy 466 P5.20.059 - Degree and organization pattern of lymphocyte populations within the active border of human colorectal cancer liver metastases: association between immunological imprint and survival Anastasia Meshcheryakova, D. Tamandl, M. Svoboda, E. Bajna, J. Stift, D. Heiden, T. Grünberger, E. Jensen-Jarolim, M. Bergmann, D. Mechtcheriakova; Vienna, Austria 467 P5.20.060 - Melanoma cells produce adenosine through a CD38/CD73 pathway and suppress CD4+ T cell proliferation Fabio Morandi, A.L. Horenstein, B. Morandi, P. Carrega, A. Chillemi, G. Zaccarello, M.C. Mingari, V. Pistoia, F. Malavasi; Genoa, Italy 468 P5.20.061 - Nasopharyngeal carcinoma-derived exosomes recruit, expand and up-regulate biological activities of human regulatory T cells Dhafer Mrizak, O. Moralès, N. Martin, Y. De Launoit, P. Busson, N. Delhem; Lille, France 469 P5.20.062 - Evaluation of the use of the CA-15-3 in monitoring of Breast cancer in A B U teaching hospital, Zaria, northern Nigeria Bolanle O.P. Musa, D.A. Dawotola, L.M.D. Yusufu, V.I. Odigie; Zaria, Nigeria 470 P5.20.063 - Prediction of Radix Astragali immunomodulatory effects of CD80 expression on THP-1 cells from chemical chromatograms by Quantitative Pattern-Activity Relationship (QPAR) Chun-har Michelle Ng, T. Lau, K. Fan, Q. Xu, F. Chau, M. Sze; Hong Kong, Hong Kong 471 P5.20.064 - Myeloid-derived suppressor cells attenuate Th1 development through IL-6 production to promote tumor progression H. Tsukamoto, S. Senju, Yasuharu Nishimura; Kumamoto, Japan 472 P5.20.065 - Evaluation of a hydroalcoholic extract of Uncaria tomentosa on dendritic cells and Th1/Th2/Th17 profile, IL-12 in breast cancer patients C.E. Nuñez, Cesar E. Nuñez, I.A. Lozada-Requena, T.P. Ysmodes, S.R. Davila, Y.P. Alvarez, C. Ocampo, J.L. Aguilar Olano; Lima, Peru 473 P5.20.066 - Allelic variants in promoter region of FOXP3 gene as a protective factor in breast cancer development Julie M.M. Oda, K.B. de Oliveira, R.L. Guembarovski, C.E.C. de Oliveira, P.M.M. Ozawa, B.K.B. Hirata, C.B. Ariza, C.Z. Campos, D.R. Derossi, M.A.E. Watanabe; Londrina, Brazil 474 P5.20.067 - Modeling leukemia immunoediting in mouse-human chimeras Giacomo Oliveira, C. Toffalori, J.M. Garcia-Manteiga, B. Camisa, A. Bondanza, E. Stupka, F. Ciceri, K. Fleischhauer, C. Bonini, L. Vago; Milano, Italy 475 P5.20.068 - Breast and kidney-expressed chemokine (CXCL14) in breast cancer Zhou Luo Ou, X. Gu, F. Lin, X. Yang, Y. Guo, Z. Shao; Shanghai, China 476 P5.20.069 - Role and potential application of chemokine-binding proteins in breast cancer Zhou Luo Ou, X. Zeng, F. Lin, X. Yang, Y. Guo, Z. Shao; Shanghai, China 477 P5.20.070 - Genetic variation in DNA repair genes: ERCC4 and XRCC3 and cervical squamous cell carcinoma risk Edyta A. Pawlak-Adamska, M. Bartosinska, I. Wlodarska-Polinska, A. Ignatowicz-Pacyna, J. Kornafel, I. Frydecka; Wroclaw, Poland 478 P5.20.071 - Silencing of claudin-10 expression on B-1 cells impaired the increased metastatic behavior of melanoma cells an in vitro coculture system Elizabeth C. Pérez, P. Xander, M.F. Laurindo, R. Novaes e Brito, B. Vivanco, L. Osugui, M. Mariano, J.D. Lopes; São Paulo, Brazil 479 P5.20.072 - Role of STAT3 signaling in MDSC-mediated immune suppression Laura Pinton, S. Solito, L. Perilli, V. Damuzzo, S. Francescato, P. Zanovello, V. Bronte, S. Mandruzzato; Padova, Italy 222 Posters - August 26 480 P5.20.073 - Inhibition of Th17 cells and induction of regulatory T cells is mediated by SOCS-1 in the tumor microenvironment of breast cancer patients Arash Pourgholaminejad, R. Eftekhari, R. Mirzaei, J. Hadjati; Tehran, Iran, Islamic Republic of 481 P5.20.074 - Characterization of Th17 cells and regulatory T cells in pleural effusions of lung cancer patients Heriberto Prado-Garcia, S. Romero-Garcia, J. Orozco-Gaytan, J.S. Lopez-Gonzalez, A. Arreola-Morales; Mexico City, Mexico 482 P5.20.075 - Expression of at least one desmoglein is essential for multicellular tumor spheroid (MCTS) formation Alexander V. Prokhorov, E.V. Svirshchevskaya; Moscow, Russian Federation 483 P5.20.076 - Polyomavirus BK large tumor antigen exerts tolerogenic signatures with immunodominant p53-binding regions in prostate cancer Maurizio Provenzano; Zurich, Switzerland 484 P5.20.077 - Role of G-protein coupled receptor 120 in tumor-promotion of human colorectal cancer Q. Wu, Liu Qian, M. Jin, J. Liu, Y. Zhang; Shanghai, China 485 P5.20.078 - Role of ectoenzymes in the interaction between myeloma, bone cells and immune effectors: the potential role of adenosine and the oxytocin/oxytocin receptor Valeria Quarona, M. Lazzaretti, A. Chillemi, A. Zito, G. Zaccarello, A.L. Horenstein, F. Saccucci, V. Pistoia, N. Giuliani, F. Malavasi; Torino, Italy 486 P5.20.079 - Mesenchymal sterm cells (MSCs) in head and neck squamous cell cancer (HNSCC) Valentina Querci, V. Santarlasci, L. Maggi, M. Capone, M. Rossi, L. Cosmi, F. Liotta, F. Annunziato; Florence, Italy 487 P5.20.080 - Defective IL-23/IL-17 axis protects p47phox-/- mice from colon cancer Cornelia Richter, J. Bandola, M. Herrero San Juan, B. Weigmann, H. Bonig, S. Brenner, H.H. Radeke; Dresden, Germany 488 P5.20.081 - Epigenetic modifications of the long pentraxin PTX3 in human colorectal cancer Marcello Rubino, C. Greco, S. Vetrano, E. Barbati, L. Laghi, R. Papait, A. Mantovani, C. Garlanda; Rozzano (MI), Italy 489 P5.20.082 - Targeting colon cancer cell NF-кB regulates tumor-associated macrophage polarization and enhances anti-tumor immune response A.E. Ryan, A. Colleran, A. O’Gorman, L. O’Flynn, J. Pindjacova, P. Lohan, M. Nosov, C. Mureau, M.D. Griffin, L.J. Egan, Oliver Treacy; Galway, Ireland 490 P5.20.083 - Tumor-specific Th17 cells orchestrate anti-tumoral responses Juan J. Sáez, S. Nuñez, F. Flores, D. Fernández, M. Rosemblatt, M.R. Bono, D. Sauma; Santiago, Chile 491 P5.20.084 - The Inhibitory effects of Metformin on tumor cell growth in hypoxia conditions Zohreh Safari, M.H. Seyedzadeh, A. Zare, J. Arasteh, R. Safaralizadeh, G.A. Kardar; Tabriz, Iran, Islamic Republic of 492 P5.20.085 - Cooperation between adenosinergic and hypoxic axes in chronic lymphocytic leukemia cells (CLL) Sara Serra, T. Vaisitti, A.L. Horenstein, F. Malavasi, S. Deaglio; Torino, Italy 493 P5.20.086 - Oxidative stress induces a temporary initial decrease of HSP70 content in EL4 lymphoma cells Olga Shustova, A. Boyko, A. Klinkova, N. Troyanova, E. Kovalenko, A. Sapozhnikov; Moscow, Russian Federation 494 P5.20.087 - Cancer/testis antigen HCA587 promotes the metastatic behavior of melanoma cells Xiao Song, J. Hao, J. Chen, W. Song, Y. Li, Y. Zhang, Y. Yin; Beijing, China 495 P5.20.088 - Immunophenotypes of Burkitt’s lymphoma cell lines alter at different EBV infection latency types Irina Spaka, A. Spaks, S. Kozireva, J. Osmjana, M. Upmane, R. Birkenfelde, V. Kalnina, S. Lejniece, I. Kholodnyuk; Riga, Latvia 496 P5.20.089 - CD11b+Ly6G+Ly6Cint myeloid-derived suppressor cells become expanded by medroxiprogesterone acetate in mammary tumor bearing hosts and suppress NK cell effector functions R.G. Spallanzani, T. Dalotto, D. Avila, A. Ziblat, C. Domaica, M. Fuertes, X. Raffo Iraolagoitia, G. Rabinovich, M. Salatino, Norbeto Walter Zwirner; Buenos Aires, Argentina 497 P5.20.090 - IL-12p40, IL-23 and IL-10 production from monocytes of patients with colorectal cancer: effect of inhibition of JNK signaling pathway Noyko S. Stanilov, S.A. Stanilova, Z. Dobreva; Stara Zagora, Bulgaria 498 P5.20.091 - Association of -1082 A/G promoter polymorphism of IL-10 gene with colorectal cancer development Noyko S. Stanilov, J.P. Jovchev, L.D. Miteva, Z.G. Dobreva, T.S. Deliysky, A.V. Avramova, S.A. Stanilova; Stara zagora, Bulgaria 499 P5.20.092 - Can humoral immunity enhance development of skin tumors? A.A. Lavezo, L.R. Carvalho, T. Canhamero, A. Borrego, W.H.K. Cabrera, J.R. Jensen, M. De Franco, O.G. Ribeiro, O.M. Ibañez, Nancy Starobinas; São Paulo, Brazil 223 Posters - August 26 500 P5.20.093 - CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer Yu Su, Y. Lin, L. Zhang, B. Liu, X. Wang, H. Li, X. Xing, X. Cheng, B. Dong, Y. Hu; Beijing, China 501 P5.20.094 - Essential involvement of tumor-derived IDO in ovarian cancer progression Yuko Tanizaki, A. Kobayashi, T. Yahata, M. Yamamoto, M. Shiro, Y. Mabuchi, S. Minami, M. Nosaka, T. Kondo, K. Ino; Wakayama, Japan 502 P5.20.095 - Immune profiling of lung cancer tissues associated with COPD Elena Tassi, C. Vegetti, P. Baldassari, A. Molla, G. Sozzi, U. Pastorino, A. Anichini; Milan, Italy 503 P5.20.096 - Targeted-Therapy attenuates local and systemic immune suppression in Solitary Fibrous Tumor patients Marcella Tazzari, T. Negri, F. Rini, B. Vergani, C. Camisaschi, A. Villa, S. Stacchiotti, L. Rivoltini, S. Pilotti, C. Castelli; Milan, Italy 504 P5.20.097 - Flow cytometric analysis of the tumour microenvironment during immune mediated tumour rejection or persistence Alexandra M. Terry, A. Buckley, J. Holst, B. Fazekas de St Groth, E. Shklovskaya; Camperdown, Australia 505 P5.20.098 - Antitumor and immunological effects of Nilotinib combined with Interleukin-2 in the B16 melanoma model involve IFN-g producing CD27+ NK cells K. Geisler, A. Reischer, B. Jacobs, I. Kroeger, K. Meinhardt, R. Bauer, A. Mackensen, B. Ryffel, Evelyn Ullrich; Frankfurt, Germany 506 P5.20.100 - Tumors with processing defects display novel tumor antigens via the non-classical HLA-E E. Doorduijn, C. Oliveira, B. Querido, M. Sluijter, Thorbald van Hall; Leiden, Netherlands 507 P5.20.101 - NLRP3 inflammasome activation is involved in breast cancer cell death in vitro Nathalia M. Vasconcelos, R.S. Fontenele, B.C. Guido, K.G. Magalhães, J.R. Correa; Brasília, Brazil 508 P5.20.102 - Influence of natural killer cells in mammary tumor in female dogs A. Matsui, M.B. Bandarra, G.M. Magalhães, P.R.R. Moreira, A.C. Alessi, D.P. Munari, Rosemeri O. Vasconcelos; Jaboticabal, Brazil 509 P5.20.103 - Antitumor activity of synthetic phosphoethanolamine in experimental colon cancer Luciana C. Veronez, L.R. Azevedo, D.O. Miranda, T.H. Geraldino, R.O. Lopes, S.B. Garcia, G.S. Bisson; Ribeirão Preto, Brazil 510 P5.20.104 - CCR5-expressing B-1 cells attract CD8 T cells to melanoma millieu and decrease tumor aggressiveness Bruno C. Vivanco, J.D. Lopes, E. Perez, P. Xander, M. Guereschi, F.T.d. Konno; São Paulo, Brazil 511 P5.20.105 - Devil Facial Tumour Disease, a devil of a cancer that is transmissible and fails to induce an immune response Greg M. Woods, A. Kreiss, H. Siddle, L. Howson, T. Kobayashi, G. Brown, C. Tovar, J. Murphy, L. Corcoran, J. Kaufman; Hobart, Australia 512 P5.20.106 - Co-existence of HLA class I expression and CD8+ T cell infiltration is associated with favorable clinical outcomes in Ewing’s sarcoma family of tumors (ESFT) Hiroki Yabe, T. Tsukahara, S. Kawaguchi, T. Torigoe, N. Sato, H. Morioka, H. Yabe; Saitama City, Japan 513 P5.20.107 - The Immunology of Ovarian Cancer Anhar Yassin; Edinburgh, United Kingdom 514 P5.20.108 - Critical role of interleukin-27 in tumor immunology Zhinan Yin; Tianjin, China 515 P5.20.109 - The role of the CXCR3 receptor ligand system in the immune escape of multiple myeloma Claudia Zelle-Rieser, S. Thangavadivel, M. Lechner, A. Brunner, R. Greil, K. Jöhrer; Innsbruck, Austria 516 P5.20.110 - A Novel Subset of Tumor-infiltrating B7-H3+CD14+HLA-DR-/low Myeloid-derived Suppressor Cells Foster Immune Privilege and Tumor Progression in NSCLC Guangbo Zhang, H. Huang, X. Zhang; Suzhou, China P6.09 VACCINE ADJUVANTS Session Time: Monday, August 26, 13:20 - 15:00 517 P6.09.01 - Commensal bacteria-derived membrane vesicles supress Th-1 dominated immune responses in vaccinated and tumor-bearing mice Esin Alpdundar, S. Yildiz, B. Bayyurt, M. Ozcan, G. Gucluler, D. Bayik, B. Gungor, I. Gursel, M. Gursel; Ankara, Turkey 518 P6.09.02 - Immunomodulatory cytokine gene expression profiles and lymphoprolifration response in hamsters vaccinated by leptospiral vaccine with several adjuvants Reza Banihashemi, M. Tebianian, J. Majidi, B. Baradaran, A. Jabbari, K. Tadayyon, S. Jalali, M. Sekhavati, R. Ghaderi, G. Shokri; Tehran, Iran, Islamic Republic of 224 Posters - August 26 519 P6.09.03 - Intradermal and subcutaneous adjuvant effects of type I enterotoxigenic Escherichia coli (ETEC) heat-labile toxin derivatives Catarina J.M. Braga, J.F. Rodrigues, S.B. Boscardin, L.C.S. Ferreira; São Paulo, Brazil 520 P6.09.04 - Investigating Layered Double Hydroxides (LDHs) as Designer Inorganic Vaccine Adjuvants Hannah C. Buckley, S. Preston, G. Williams, O. Rysnik, D. Lunn, B. Lambrecht, D. O’Hare, J. Austyn; Oxford, United Kingdom 521 P6.09.05 - A novel allergen-adjuvant conjugate suitable for allergen-specific Th2 redirection E. Cardilicchia, Lucia Filì, A. Casini, L. Maggi, C. Manuelli, E. Occhiato, F. Boscaro, S. Romagnani, E. Maggi, P. Parronchi; Florence, Italy 522 P6.09.06 - Helix pomatia Hc (HpH) hemocyanin as protein-carrier and bio-adjuvant of bacterial and viral proteins Stela Chausheva, V. Gesheva, N. Mihaylova, K. Idakieva, L. Doumanova, A. Tchorbanov; Sofia, Bulgaria 523 P6.09.07 - Novel vaccine adjuvant for induction of cellular and humoral immunity Sandrine Crabe, J. Nitcheu, V. Serra; Evry, France 524 P6.09.09 - Long-term antigen-specific antibody responses against RSV glycoprotein by an osmotic active nanocarrier via enhanced phagocytosis Jannatul Firdous, M.A. Islam, S. Park, B. Shim, M. Song, J. Chang, D. Boraschi, S. Han, C. Cho, C. Yun; Seoul, Korea, Republic of 525 P6.09.10 - Autologous hsp70 enhances the expression of adhesion, fusion receptors, HLA and costimulatory molecules on murine peritoneal macrophages in a T cell lymphoma Pramod K. Gautam, P. Deepak, S. Kumar, A. Acharya; Varanasi, India 526 P6.09.11 - Mast cells redirect the differentiation of dendritic cells away from tolerance and towards immunogenicity S. Karaki, F. Capel, A. Biola-Vidamment, T. Barbin, G. Schlecht-Louf, T. Tran, M. Dy, M. Arock, F. Bachelerie, Veronique Godot; Creteil, France 527 P6.09.12 - Adjuvant potential of QS-21 on protective efficacy of DPT vaccine Camy Goyal, S. Mishra, M. Gautam, S. Gairola, B. Patwardhan; Lalru, India 528 P6.09.13 - An adjuvant, fungal immunomodulatory protein (FIP)-fve, potentiates the immune response by engaging the co-stimulatory molecules, CD27 and CD134 (OX-40) Ong Haris, K. I-Chun, H. Chiung-Hui; Singapore, Singapore 529 P6.09.14 - SCE 350ET: A plant derived adjuvant inducing Th1 and Th2 type immune response Bindhya Jayashankar, K.P. Mishra, D. Singh, S. Murthy, R.K. Tulswani, K. Udayasankar, K. Mishra, L. Ganju, S.B. Singh; Delhi, India 530 P6.09.15 - Oligomannose-coated liposome as a novel antigen-delivery vehicle and an adjuvant for induction of cellular immune responses Naoya Kokima, M. Ishii, Y. Kawauchi; Hiratsuka, Japan 531 P6.09.16 - Fucoidan effect on mononuclear leukocyte immunophenotype and lymphoid organ morphology in mice Olga V. Lebedinskaya, E.A. Lebedinskaya, N.K. Akhmatova, I.D. Makarenkova; Perm, Russian Federation 532 P6.09.17 - Chitosan effect on the inactivated influenza vaccine immunogenicity N.K. Akhmatova, S.S. Markushin, E.A. Akhmatov, L.A. Geiderova, E.V. Sorokina, N.P. Utkina, E.A. Ilinykh, Olga V. Lebedinskaya; Perm, Russian Federation 533 P6.09.18 - Functional and immunophenotype characteristics of peripheral blood mononuclear leukocytes from healthy donors under sodium nucleinate effect Olga V. Lebedinskaya, E.A. Lebedinskaya, N.K. Akhmatova; Perm, Russian Federation 534 P6.09.19 - Studies with novel synthetic immunogens as a tool for efficient antibody generation J. Malik, G. Dunau, G. Casi, C. Cattaneo, C. Fessele, M. Soukupova, S. Dziadek, Valeria Lifke; Penzberg, Germany 535 P6.09.20 - EDA-streptavidin fusion protein conjugated to biotinylated HCV-NS3 protein for the induction of T cell immune responses against NS3 Teresa Lozano, L. Arribillaga, L. Villanueva, M. Gorraiz, M. Durantez, N. Casares, F. Borras-Cuesta, P. Sarobe, J. Prieto, J. Lasarte; Pamplona, Spain 536 P6.09.21 - Development of a new microparticle vaccine adjuvant with the ability to deliver peptides to dendritic cells Francesco Mainini, S. Young, D. Larsen, G. Webster, M. Eccles; Dunedin, New Zealand 537 P6.09.22 - PolyICLC increases the immunogenicity and efficacy of the filovirus virus-like particle (VLP) vaccine Karen O. Martins, T.K. Warren, J. Wells, A. Bergeron, J. Steffens, S. van Tongeren, S. Bavari; Frederick, United States 538 P6.09.23 - Physicochemical and immunological parameters of the anti-allergic adjuvanted vaccine PROLINEM-DS Arelis Más Quintero, W. Ramírez, A. Labrada, Y. Oliva, M. Mateo, V. Bourg, D. Torralba, J. Llama; Mayabeque, Cuba 225 Posters - August 26 539 P6.09.24 - Immunogenic and adjuvant properties of OmpS1 and OmpS2 porins Mario A. Moreno-Eutimio, R. Pastelin-Palacios, C. Perez-Shibayama, C. Gil-Cruz, M. Fernández-Mora, A. Isibasi, E. Calva, C. Lopez-Macias; Mexico City, Mexico 540 P6.09.25 - The role of alum-induced host DNA release in antigen-presenting cell activation and T cell priming Laura E. Noges, A.S. McKee, J. Kappler, P. Marrack; Denver, United States 541 P6.09.26 - Salmonella typhi porins are adjuvants on the specific immune responses to co-inmunized antigens Marisol Pérez-Toledo, R. Pastelin-Palacios, C. Gil-Cruz, C. Pérez-Shibayama, M. Moreno-Eutimio, A. Cunningham, M. Pérez-Tapia, L. Bonifaz, A. Isibasi, C. López-Macías; Mexico City, Mexico 542 P6.09.27 - Therapeutical effects of a novel nDer p2-conjugated TLR7 in a mouse model of lung inflammation Sara Pratesi, F. Nencini, G. Petroni, P. Parronchi, E. Maggi, A. Vultaggio; Florence, Italy 543 P6.09.28 - Inhibitory effects of silibinin on invasive properties of human breast cancer cell line, MDA-MB-231, through suppression of the proteolytic cascade of cathepsin B/ urokinase-type plasminogen activator Shahrzad Rahimifar, M. Yousefi, M. Momeny, A. Emami; Tehran, Iran, Islamic Republic of 544 P6.09.29 - Effective mucosal protection against sexually-transmitted viral infections is provided by MEC/CCL28 Veronica Rainone, G. Dubois, L. Gissmann, V. Temchura, K. Uberla, M. Nebuloni, D. Trabattoni, F. Veas, M. Clerici; Milan, Italy 545 P6.09.30 - Adjuvants as possible solution to polysaccharide unconjugated vaccines B. Romeu, M. Lastre, M. Cuello, O. Cabrera, E. González, D. González, A. Mandariote, L. García, D. Cardoso, Oliver Pérez; Havana, Cuba 546 P6.09.31 - Influence of phosphate salts and alum content on to the immunogenicity and stability of a Dermatophagoides siboney adjuvanted vaccine Roxana Samalea, W. Ramírez, B. Tamargo, D. Torralba, A. Morejón, D. Martínez, A. Más, J.F. Infante, V. Bourg, A. Labrada; Mayabeque, Cuba 547 P6.09.32 - GM-CSF enhances the cellular immune response elicited by a DNA vaccine against HIV even in a low dose approach. Vinicius C. Santana, R.R. Almeida, S.P. Ribeiro, D.S. Rosa, J. Kalil, E. Cunha-Neto; São Paulo, Brazil 548 P6.09.33 - Proteus mirabilis flagellin, neither a good adjuvant nor a protective antigen against urinary tract infection Paola Scavone, A. Umpiérrez, A. Rial, J.A. Chabalgoity, P. Zunino; Montevideo, Uruguay 549 P6.09.34 - Circulating influenza-specific CD4+ ICOS1+ IL-21+ expand after vaccination, exert helper function and predict antibody responses in humans Fabiana Spensieri, E. Borgogni, L. Zedda, M. Bardelli, F. Buricchi, G. Volpini, S. Tavarini, O. Finco, G. Del Giudice, F. Castellino; Siena, Italy 550 P6.09.35 - Immunological characterization of M13 phage vaccine Kazuhisa Sugimura, T. Osako, S. Kawabata, R. Miyahara, T. Tsurumaru, R. Oda, D. Tomari, R. Shioya, S. Hashiguchi; Kagoshima, Japan 551 P6.09.36 - New proteoliposomevaccineformulation from N. meningitidisserogroup B, without aluminum hydroxide, retains its antimeningococcalprotectogenic potential as well as Th-1 adjuvant capacity Beatriz Tamargo; Habana, Cuba 552 P6.09.37 - Evaluation of the Adjuvant properties for Chitosan-Polyvinylpyrrolidone-based Nanoparticles I.Y. Izaguirre-Hernández, A.Y. Tenorio-Barajas, V.M. Altuzar-Aguilar, C.O. Mendoza-Barrera, Hector Vivanco-Cid; Veracruz, Veracruz, Mexico 553 P6.09.38 - A Non-lytic form of Listeriolysin O induces Human Dendritic Cells to produce IL-12 and IL-23 K. Hernandez-Flores, P. Thomas-Dupont, F. Mijangos-Zamudio, Y. Paterson, Hector Vivanco-Cid; Veracruz, Veracruz, Mexico 554 P6.09.39 - Adjuvant-induced muscle ATP release potentiates response to vaccination Maria Vono, M. Taccone, P. Caccin, M. Gallotta, M. Pallaoro, R. Rappuoli, E. De Gregorio, F. Di Virgilio, C. Montecucco, A. Seubert; Padova, Italy 555 P6.09.40 - Effect of monogalactosyldiacylglycerol from different marine macrophytes on conformation and immunogenicity of hemagglutinin of Influenza A virus H1/N1 A/California/07/2009 Vladimir N. Vorontsov, N.M. Sanina, E.Y. Kostetsky, A.V. Tsybulsky, L.A. Davydova, A.N. Mazeika, N.S. Vorobieva, V.L. Shnyrov; Vladivostok, Russian Federation 556 P6.09.41 - Cyclic-di-GMP based immune stimulatory formulations as novel vaccine adjuvants and anti-cancer agents Soner Yildiz, E. Alpdundar, B. Bayyurt, M. Ozcan, G. Gucluler, D. Bayik, B. Gungor, I. Gursel, M. Gursel; Ankara, Turkey 226 Posters - August 26 P6.10 MUCOSAL VACCINES Session Time: Monday, August 26, 13:20 - 15:00 557 P6.10.01 - Determinants of immune responses to mucosal delivery of a malaria parasite protein on Lactococcus lactis cell walls and co-administration of an inducer strain Sivagowry Anavarathavinayagamoorthy, R. Ramasamy; Colombo, Sri Lanka 558 P6.10.02 - Mucosal delivery of ACNPV baculovirus driving expression of the Gal-lectin LC3 fragment confers protection against amoebic liver abscess in hamster Julio C. Carrero, D.M. Meneses-Ruiz, J.H. Aguilar-Diaz, J. Hernandez-Ruiz, A. Luz-Madrigal, L. Vaca, J.P. Laclette; Ciudad de México, Mexico 559 P6.10.03 - Mucosal influenza vaccine comprising of M2e-HSP70 formulated with N-Trimethyl chitosan(TMC) particles induces strong M2e specific immune responses Mehran Dabaghian, S. Ebrahimi, M. Tebianian, G. Nikbakht Brujeni; Tehran, Iran, Islamic Republic of 560 P6.10.04 - Beta-glucan particles as novel antigen delivery systems: towards oral vaccination Rebecca De Smet, S. Verschuere, T. Demoor, L. Allais, M. Dierendonck, B.G. De Geest, C. Pilette, C. Cuvelier; Ghent, Belgium 561 P6.10.05 - Hsp65-producing Lactococcus lactis prevents experimental colitis by IL-10- and TLR2-dependent pathways Ana M.C. Faria; Belo Horizonte, Brazil 562 P6.10.06 - Prime-boost strategies in mucosal immunization affect local IgA production and the type of Th response Fabio Fiorino, E. Pettini, G. Pozzi, D. Medaglini, A. Ciabattini; Siena, Italy 563 P6.10.07 - Nanogel-based PspA nasal vaccine induces S. pneumoniae -specific neutralizing antibody immune responses in nonhuman primates Yoshiko Fukuyama, Y. Yuki, Y. Katakai, H. Takahashi, S. Sawada, H. Shibata, M. Mejima, S. Kurokawa, K. Akiyoshi, H. Kiyono; Tokyo, Japan 564 P6.10.08 - Immunisation using a sustained release vaccine generates functional CD8 T cell memory Andrew J. Highton, S. Hook, R. Kemp; Dunedin, New Zealand 565 P6.10.09 - In vitro Inhibition of Staphylococcus aureus Isolates by Anti-Anti-Idiotypic Antibodies to Staphylococcal Protein A (SpA) Angel A. Justiz Vaillant, P. Akpaka, M. Smikle, N. McFarlane-Anderson; Saint Augustine, Trinidad and Tobago 566 P6.10.10 - Nanogel-based pneumococcal surface protein A (PspA) intranasal vaccine prevents invasive disease and nasal colonization by pneumococcus Ilgyu Kong, A. Sato, Y. Yuki, T. Nochi, H. Takahashi, S. Sawada, M. Mejima, K. Okada, K. Akiyoshi, H. Kiyono; Tokyo, Japan 567 P6.10.11 - The protective activity of the bacterial antigens in mucosal route of immunization in mice Olga V. Lebedinskaya, N.P. Utkina, N.K. Akhmatova; Perm, Russian Federation 568 P6.10.13 - T-cell priming characterisation through a systems biology approach E. Pettini, Gennaro Prota, A. Ciabattini, A. Boianelli, F. Fiorino, G. Pozzi, A. Vicino, D. Medaglini; Siena, Italy 569 P6.10.15 - Encapsulation of antigens in whole plant cells functions as a combined production and delivery platform for oral vaccines Robert P. Shepherd, A.M. Walmsley; Clayton, Australia 570 P6.10.16 - Establishment of murine norovirus S7 infection system for vaccine development Natsumi Takeyama, Y. Chen, Y. Tohya, K. Oroku, H. Kiyono, Y. Yuki; Ome, Tokyo, Japan 571 P6.10.17 - Maternal antibodies enhance systemic and local immune responses after early mucosal immunization in a porcine model Marco A. Vega-Lopez, E.R. Guzman-Bautista, C.E. Garcia-Ruiz, A.L. Gama, C. Ramirez-Estudillo, O.I. Rojas; Mexico, D.F., Mexico 572 P6.10.18 - M-cell targeting strategy improved the immunogenicity of viral myocarditis-specific mucosal DNA vaccine Yan Yue, S. Xiong, W. Xu; Suzhou, Jiangsu Province, China P7.05 EVOLUTION OF THE IMMUNE SYSTEM AND COMPARATIVE IMMUNOLOGY Session Time: Monday, August 26, 13:20 - 15:00 573 P7.05.01 - Innate immunity of the Mytilus galloprovincialis mussel and environmental pollution: Study of some parameters and interactions Younes Bouallagui, R. Ben Younes, R. Oueslati; Bizerta, Tunisia 227 Posters - August 26 574 P7.05.02 - The role of bidirectional activity of NWC promoter in the evolution of RAG transposon L. Sniezewski, A. Laszkiewicz, L. Bzdzion, M. Kasztura, S. Walach, P. Kisielow, Malgorzata Cebrat; Wroclaw, Poland 575 P7.05.03 - Amyloidogenesis as protective response in invertebrates and vertebrates Magda de Eguileor, R. Girardello, A. Grimaldi, D. Malagoli, L. Pulze, G. Tettamanti, E. Ottaviani, R. Valvassori; Varese, Italy 576 P7.05.04 - Innate immunity and evolution of antioxidant defenses: the methionine sulfoxide reductase genes in the ciliated protozoan Tetrahymena thermophila Diana Ferro, F. Cattalini, O. Coppellotti, R. Bakiu, E. Piccinni, G. Santovito; Padova, Italy 577 P7.05.05 - Evolution of the complement system: ancient molecules and new evidences from tunicates Nicola Franchi, L. Ballarin, N. Parrinello; Palermo, Italy 578 P7.05.07 - Characterization of the IL-17 and IL-17 receptor families in lampreys Qifeng Han, M. Hirano, M. Cooper; Atlanta, United States 579 P7.05.08 - Genomic analysis in inbred mice provides insights into the evolutionary history of NKG2D ligand genes Mizuho Kondo, J. Kasamatsu, Y. Sarada, N. Otsuka, T. Takada, A. Toyoda, A. Fujiyama, T. Shiroishi, M. Kasahara; Sapporo, Japan 580 P7.05.09 - Cranial base (CB)/brain and immune system of the fetus and neonate in concert in evolutionary development Alexandra Kunz, C. Iliadis; Boston, United States 581 P7.05.10 - A Research Coordination Network in Ecological Immunology Lynn B. Martin, D.M. Hawley, D.R. Ardia; Tampa, United States 582 P7.05.11 - Functional analyses of lymphocytes and granulocytes isolated from the thymus, spiral valve intestine, spleen, and kidney of juvenile Australian lungfish, Neoceratodus forsteri Mohammad G. Mohammad, M.H. Golakani, J. Joss; Sydney, Australia 583 P7.05.12 - The introduction of monoclonal antibody Institute: the region’s largest student center Mohammad Naghavi - Behzad, M. Ghojazadeh, A. Naghavi-Behzad, R. Piri; Tabriz, Iran, Islamic Republic of 584 P7.05.13 - The cattle germline IGHV repertoire is very limited Mikael Niku, J. Liljavirta, K. Durkin, E. Schroderus, A. Iivanainen; Helsinki, Finland 585 P7.05.14 - Risk Factors Associated with the Acquisition of HIV/STIs in Female Sex Workers (FSWs) in Lagos Nigeria Ngozi M. Otuonye, O. Enabulele Onmoiwu, H. Aliyu, C. Onwuamah; Yaba, Lagos, Nigeria 586 P7.05.15 - Boosting heterosubtypic neutralization antibodies in recipients of the 2009 pandemic H1N1 influenza vaccine Chao Qiu, Y. Huang, Y. Hu, Z. Yuan, X. Zhang, J. Xu; Shanghai, China 587 P7.05.16 - R4 regulators of G-protein signaling share a common ancestry with the MHC paralogons Jaanus Suurväli, J. Robert, P. Boudinot, S. Rüütel Boudinot; Tallinn, Estonia 588 P7.05.17 - Comparative study on primary structure and function of rhesus monkey and human granulocyte-macrophage colony stimulating factor Ze Tao, H. Yang, D. Jia, L. Wan, J. Cheng, X. Lu; Chengdu, Sichuan, China 589 P7.05.18 - The Drosophila immune response to Invertebrate Iridescent Virus 6 Cara C. West, W. Theurkauf, N. Silverman; Worcester, United States P7.07 VETERINARY IMMUNOLOGY Session Time: Monday, August 26, 13:20 - 15:00 590 P7.07.02 - Tumoral necrosis factor alpha (TNF-alpha) and interleukine 1 alpha (IL-1 alpha) expression in intestinal mucosa of young alpacas (vicugna pacos) with histological diagnostic of necrotic enteritis Carla Bardález, A. Manchego, K. Chiok, N. Sandoval, J. More, M. Ramírez, H. Rivera; Lima, Peru 591 P7.07.03 - Dynamics of T and B cells in lymphoid organs during the experimental infection of specific-pathogen free (SPF) layers with Fowl adenovirus (FAdV) serotype 4 Ivan Best, W. Medina, E. Choque, M. Fernández-Sánchez, M. Fernández-Díaz; Chincha, Peru 592 P7.07.04 - Immunological assessment of Aleuria Aurantia Lectin Gesa M. Bindke, F. Roth-Walter, J. Singer, K. Jaeger, R. Brunthaler, K. Köhler, A. Willensdorfer, E. Jensen-Jarolim; Vienna, Austria 228 Posters - August 26 593 P7.07.05 - Immunodiagnosis of porcine cysticercosis: Identification of accurate antigens through immunoproteomics Raúl J. Bobes, Y. Diaz Masmela, G. Fragoso, J. Ambrosio, G. Rosas, K.J. Estrada, J.C. Carrero, E. Sciutto, J.P. Laclette; Mexico City, Mexico 594 P7.07.06 - Monocyte chemoattractant protein-1 polymorphisms influence T cell proliferation and T subsets Hsiu-Luan Chang, H. Chaung, J. Yu, Y. Li, S. Liu, W. Chung; Pingtung, Taiwan 595 P7.07.07 - Soluble FliC fusion protein cloned from Salmonella Enteritidis stimulates TLR7 and TLR8 expressions Hso-Chi Chaung, Y. Lien, M. Wu, L. Hung, W. Chung; Pingtung, Taiwan 596 P7.07.08 - Gentamicin-attenuated Leishmania infantum vaccine: protection of dogs against canine visceral leehmaniasis in endemic areas of southeast of Iran Hamid Daneshvar, M. Namazi, M. Molaie, H. Kamiabi, S. Phillips, R. Burchmore; Kerman, Iran, Islamic Republic of 597 P7.07.09 - Bm86 and Hd86 anti-Hyalomma scupense tick vaccine trials in cattle, efficacy and limits Yousr Galaï, M. Ben Saïd, M. Gharbi, M. Jedidi, J. de la Fuente, M. Darghouth; Belvedere Tunis, Tunisia 598 P7.07.10 - Evaluation of vaccines against foot and mouth disease in the mouse model, correlation with efficacy in cattle Victoria Gnazzo, E. Pereyra, V. Quattrocchi, I. Soria, C. Langellotti, C. Mongini, V. Lopez, E. Smitsaart, P. Zamorano; Capital Federal, Argentina 599 P7.07.11 - Producing Anti-Somatostatin-14 in Eggs of Immunized Chickens and Evaluating Antibody by ELISA Fariba Golchinfar, R. Madani; Karaj, Iran, Islamic Republic of 600 P7.07.12 - Development of monoclonal antibodies against (PPR) virus Fariba Golchinfar, R. Madani, T. Emami; Karaj, Iran, Islamic Republic of 601 P7.07.13 - Participation of Treg cells in equine Recurrent Airway Obstruction Claudio Henriquez, G. Morán, B. Perez, N. Morales, H. Folch; Valdivia, Chile 602 P7.07.14 - Emetic potential of newly identified staphylococcal superantigens Ken’ichi Imanishi, K. Omoe, H.K. Ono, H. Kato, K. Shinagawa, J. Yagi, A. Nakane, T. Uchiyama, D. Hu; Tokyo, Japan 603 P7.07.15 - The technique for large-scale production of CpG DNA adjuvant and applications in avian vaccines H. Chaung, L. Hung, Y. Tsai, Yi-Yang Lien; Pingtung, Taiwan 604 P7.07.16 - Development of an ELISA for determination of potency in snake anti venoms Rasool Madani, F. Golchinfar, T. Emami; Karaj, Iran, Islamic Republic of 605 P7.07.17 - Determination of lymphocytes subpopulations in peripheral blood cells of dogs with atopic dermatitis Alicja Majewska, K. Dembele, M. Gajewska, T. Motyl; Warsaw, Poland 606 P7.07.18 - Human anti-langerin (CD207) polyclonal antibodies detect epidermal Langerhans-like cells in the sea turtle (Chelonia mydas) Fernando A. Muñoz, J. Calderon-Amador, A. Negrete-Philippe, L. Flores-Romo; San Luis Potosí, Mexico 607 P7.07.19 - Isolation and characterization of recombinant single chain fragment variable antibodies against Toxoplasma gondii surface antigen Mohadese Nakhaei Moghadam, M. Golchin; Kerman, Iran, Islamic Republic of 608 P7.07.20 - Failures of immunization in animals with reference to the West Africa sub-region Moses O. Odugbo; Vom, Nigeria 609 P7.07.21 - Polyspecific antigen binding by bovine immunoglobulin heavy- and light-chain variable domains Yfke Pasman, A.K. Kaushik; Guelph, Canada 610 P7.07.22 - Pathogenesis of pancytopenia in canine visceral leishmaniasis: bone marrow morphological alterations and IGF-I and IL-7 mRNA expressions Flaviane A. Pinho, S.I. Miyashiro, L.S. Silva, E.M. Ramos-Sanchez, F.A.L. Costa, H. Goto; São Paulo, Brazil 611 P7.07.23 - Booster BCG vaccination modulates response against Mycobacterium bovis-PPD in dairy herds with tuberculosis Elsa Ramírez, C. Estrada, A. Ruiz, H. Esquivel, L. Higareda, G. López, L. Bojórquez; Guadalajara, Mexico 612 P7.07.24 - Improvement in bovine haemorrhagic septicaemia vaccine potency and efficacy by aluminium nanoparticles and keyhole limpet hemocyanin, and an approach to develop a DIVA strategy Susim M. Ray; Hisar,Haryana, India 229 Posters - August 26 613 P7.07.25 - TIR8/SIGIRR is expressed in tissues of adult and embryo chicken Federica Riva, G. Manarolla, L. Turin; Milan, Italy 614 P7.07.26 - Infection and immunity during leptospirosis disease in Golden Syrian Hamster: approaching for vaccine biological models Luis Alfredo Rosario Fernandez; Havana, Cuba 615 P7.07.28 - Ocular infectious bronchitis virus vaccination induces different immune responses in the mucosal and systemic immune compartment Frederik W. van Ginkel, R.S. Gurjar, N. Orr, S.L. Gulley; Auburn, United States 616 P7.07.29 - Expression of TNF-alpha mRNA in canine mammary tumors as a potential marker for tumor evolution T.L.L. Castanheira, E. Garrido, F.S. Fernando, M.C. Rosolem, H.J. Montassier, Rosemeri O. Vasconcelos; Jaboticabal, Brazil 617 P7.07.30 - Novel dendrimeric peptide: Immune response and protection against Foot and Mouth Disease Virus (FMDV) induced by synthetic peptides in cattle I. Soria, V. Quattrocchi, C. Langellotti, S. Digiacomo, D. Buscafusco, B. Garcia de la Torre, D. Andreu, F. Sobrino, E. Blanco, Patricia Zamorano; Buenos Aires, Argentina 618 P7.07.31 - Establishment and characterization of monoclonal antibodies against tumor-associated antigen(s)in Mc29 virus-transformed chicken hepatoma cells Tanya Zhivkova, R. Alexandrova; Sofia, Bulgaria 619 P7.07.32 - Expression of the novel antigen receptor (IgNAR) in the bamboo shark and isolation of antigen-specific IgNAR domains from shark antibody repertoires Stefan Zielonka, M. Empting, P. Ockelmann, M. Lierz, H. Kolmar; Darmstadt, Germany 230 Posters - August 27 Panel N° P1.03 NK CELLS AND NK RECEPTORS Session Time: Tuesday, August 27, 13:20 - 15:00 001 P1.03.01 - Sp1 transcription factor is involved in the regulation of NKG2D ligands in tumor cells and during tumor Progression Andrea Acebes Huerta, L. Huergo Zapico, A. Lopez Soto, A. Fernandez Guizán, M. Villa Álvarez, S. González Rodríguez; Gijón, Spain 002 P1.03.02 - A novel immunological approach to prevent HCV recurrence in liver transplantation Ester Badami, P. Pizzillo, D. Galvagno, M. Spada, B. Gridelli, P. Conaldi; Palermo, Italy 003 P1.03.03 - D56+ cells in demyelinating polyneuropathies Irina P. Balmasova, O.L. Timchenko, R.I. Sepiashvili, N.D. Yushchuk; Moscow, Russian Federation 004 P1.03.04 - Assessment of natural killer receptors and activity in severe and moderate Chronic Fatigue Syndrome S.L. Hardcastle, Ekua W. Brenu, D. Staines, S. Marshall-Gradisnik; Gold Coast, Australia 005 P1.03.05 - Host response to murine CMV in class I MHC disparate mice reveals primacy of licensed NK cells in viral control Michael G. Brown, J. Prince, A. Lundgren, M.D. Stadnisky, S.D. Turner, W.T. Nash, A. Beeber; Charlottesville, United States 006 P1.03.06 - ADAM10 contributes to MICA/B shedding from multiple myeloma cells in response to genotoxic stress Francesca Cecere, A. Zingoni, R. Molfetta, A. Soriani, C. Fionda, M.T. Petrucci, M.R. Ricciardi, R. Paolini, M. Cippitelli, A. Santoni; Rome, Italy 007 P1.03.07 - Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors J. Ni, Mathias Miller, A. Cerwenka; Heidelberg, Germany 008 P1.03.08 - N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation Elena Ciaglia, S. Pisanti, P. Picardi, C. Laezza, A. Malfitano, A. D’Alessando, P. Gazzerro, E. Carbone, M. Bifulco; Fisciano, Italy 009 P1.03.09 - NK cells in dasatinib-treated chronic myeloid leukemia patients are terminally differentiated effector cells lacking homing and KIR receptors Beatriz Colom-Fernandez, A. Kreutzman, B. Maestro Gutiérrez, V. López Huete, V. García-Gutiérrez, J. Steegmann, C. Muñoz Calleja; Madrid, Spain 010 P1.03.10 - Induction of functional NK receptors on peripheral blood CD8+ T cells Margareta Correia, M. Miller, A. Stojanovic, A. Cerwenka; Heidelberg, Germany 011 P1.03.11 - Receptors of NK cells and lymphocytes subsets in patients stage II and III breast cancer L.J. Najar Acosta, A. Daneri Navarro, G. Ramirez Rosales, R.A. Franco Topete, A. Oceguera Villanueva, J.M. Castro Cervantes, E. Salas Gonzalez, J.C. Canton Romero, A. Quintero Ramos, Alicia del Toro Arreola; Guadalajara, Mexico 012 P1.03.12 - An approach to the immunophenotypic signature of selected CD4+NKG2D+ T cell subsets M. Garcia-Chagollan, M. Bueno-Topete, L. Jave-Suarez, S. Fujimura-Hernandez, A. Cid-Arregui, A. Aguilar-Lemarroy, Susana del Toro-Arreola; Guadalajara, Mexico 013 P1.03.13 - HMPV infection, immune evasion and its elimination Mohammad Diab, A. Vitenshtein, O. Mandelboim; Jerusalem, Israel 014 P1.03.14 - Neuroblastoma-derived transforming growth factor (TGF) β1 modulates the chemokine receptor repertoire of human resting Natural Killer Cells Alessandra Dondero, F. Bellora, L. Moretta, A. Castellano, F. Locatelli, M.V. Corrias, A. Moretta, C. Bottino, R. Castriconi; Genova, Italy 015 P1.03.15 - Related Human Cytomegalovirus Genes US18 and US20 Target MICA for Lysosomal Degradation Ceri A. Fielding, V. Prodhomme, R. Aicheler, S. Seirafian, J. Davies, R. Stanton, A. Davison, P. Lehner, P. Tomasec, G. Wilkinson; Cardiff, United Kingdom 016 P1.03.16 - Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function Jessica Filtjens, S. Taveirne, A. Van Acker, E. Van Ammel, M. Van Hees, T. Kerre, T. Taghon, B. Vandekerckhove, J. Plum, G. Leclercq; Ghent, Belgium 017 P1.03.17 - Inhibition of Glycogen Synthase Kinase-3 increases NKG2D Ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in Multiple Myeloma cells: role of STAT3 Cinzia Fionda, G. Malgarini, A. Soriani, A. Zingoni, F. Cecere, M. Iannitto, M. Ricciardi, M. Petrucci, A. Santoni, M. Cippitelli; Rome, Italy 018 P1.03.18 - Do NK cells play a role in the possible association between natalizumab treatment and the development of melanoma? Ilaria Gandoglia, A. Laroni, P. Carrega, G.L. Mancardi, G. Ferlazzo, A. Uccelli; Genoa, Italy 231 Posters - August 27 019 P1.03.19 - Elucidating the role of the natural killer cell receptor, Ncr1, in controlling melanoma metastases using in vivo reflectance confocal microscopy Ariella Glasner, A. Levi, J. Enk, T. Neuman, C.D. Enk, O. Mandelboim; Jerusalem, Israel 020 P1.03.20 - The receptor KIR3DS1 expressed by NK cell is associated with HCV viral clearance Rafael Gonzalez, A. Rivero-Juarez, B. Manzanares, Á. Camacho, M. Frías, A. Martínez, L. Castro, A. Rivero, J. Peña; Córdoba, Spain 021 P1.03.21 - Measurement of natural killer cell apoptotic inducing lytic proteins in peripheral blood mononuclear cells and isolated natural killer cells Teilah K. Huth, E.W. Brenu, K.J. Ashton, D. Staines, S.M. Marshall-Gradisnik; Gold Coast, Australia 022 P1.03.22 - Functional NK cells developed from human hematopoietic stem cell in human interleukin-2 transgenic NOG mice Ikumi Katano, R. Ito, T. Takahashi, M. Ito; Kawasaki, Japan 023 P1.03.23 - Multi-step defect in NK cells and acute myeloid leukemia interaction Zena Khaznadar, N. Setterblad, G. Henry, S. Agaugue, E. Raffoux, N. Boissel, H. Dombret, A. Toubert, N. Dulphy; Paris, France 024 P1.03.24 - Differential requirements of activating and inhibitory Ly49 receptors in recognition of MCMV-infected cells M. Babic-Cac, V. Juranic-Lisnic, M. Pyzik, B. Popovic, S.M. Vidal, S. Jonjic, Astrid Krmpotic; Rijeka, Croatia 025 P1.03.25 - Spinal Cord Injury-induced Immune Depression Syndrome - the role of NK and T cells Inês Laginha; Berlin, Germany 026 P1.03.26 - Cytomegalovirus regulation of mouse PVR Tihana Lenac Rovic , N. Stanietsky, S. Jordan, V. Juranic Lisnic , A. Tomic, M. Babic, A. Krmpotic, P. Tsukerman, O. Mandelboim, S. Jonjic ; Rijeka, Croatia 027 P1.03.27 - Regulatory roles of novel NK-like CD56brightCD11c+ cells on expansion of γδ T cells and memory CD8+ T cells Wen Li, H. Yammamoto, K. Yamanishi, H. Yamanishi, H. Okamura; Nishinomiya, Japan 028 P1.03.28 - Structure of the human activating receptor NKp65 bound to its keratinocyte ligand KACL (CLEC2A) reveals basis for genetically linked recognition in the natural killer gene complex Yili Li, Q. Wang, S. Chen, P.H. Brown, R.A. Mariuzza; Rockville, United States 029 P1.03.29 - Crosstalk between Dendritic Cells and NK cells in the Immune Response against the dimorphic fungus Paracoccidioides brasiliensis Larissa N.A. Longhi, M.C. Ferreira, M.H.S.L. Blotta, R.L. Mamoni; Campinas, Brazil 030 P1.03.30 - Interleukin-21 promotes the differentiation of a population of natural killer lymphocytes expressing CD86 and HLA-DR with the ability to activate naive CD4 T cells Romain Loyon, E. Picard, A. Claude, J. Pallandre, O. Adotevi, Y. Godet, C. Borg; Besançon, France 031 P1.03.31 - NK cell reconstitution following manipulated or un-manipulated haploidentical hematopoietic stem cell transplantation in leukemia patients Raffaella Meazza, M. Falco, C. Tuberosa, F. Loiacono, M. Mingari, A. Moretta, A. Bacigalupo, L. Moretta, F. Locatelli, D. Pende; Genova, Italy 032 P1.03.32 - Simultaneously expression of NKG2DL MICA/MICB and NKG2D receptor on human cervical cancer cells J-F Mendoza-Rincon, S.B.C. Bautista-Castillo, C.M.R. Mendoza-Rodriguez; Mexico City, Mexico 033 P1.03.33 - Characterisation of chicken NK cell receptors El Kahina Meziane, N. Potts, T. Pizzari, D. Richardson, K. Watson, T. Goebel, J. Kaufman; Cambridge, United Kingdom 034 P1.03.34 - Dopaminergic D5 Receptor-mediated inhibition of NK cell proliferation and production of IFN-γ Joanna Mikulak, L. Bozzo, A. Roberto, P. Tentorio, S. Bonaldo, D. Mavilio; Rozzano (MI), Italy 035 P1.03.35 - Helicobacter pylori increases NK cell response increasing ULBP2 surface expression in adenocarcinoma gastric cell lines María C. Molina, C.J. Hernández, C.H. Ribeiro, M. Garrido-Tapia, K. Kramm; Santiago, Chile 036 P1.03.36 - Adenosine produced by a CD38-mediated pathway in CD56bright CD16- NK cells inhibits autologous CD4+T cell proliferation Fabio Morandi, A.L. Horenstein, A. Chillemi, G. Zaccarello, F. Malavasi, V. Pistoia; Genoa, Italy 037 P1.03.37 - Correlation between natural killer cells functionality and response to trastuzumab treatment in HER2+ breast cancer patients Lapo Morelli, M. Ciranna, G. Curigliano, G. Penna, M. Rescigno; Milan, Italy 232 Posters - August 27 038 P1.03.38 - Modulation of activatory and inhibitory receptors of NK cells by CD137 costimulation Shadi Navabi, N.H.J.H. Doroudchi, M; Shiraz, Iran, Islamic Republic of 039 P1.03.39 - Natural killer cells in upper respiratory airway Kazunari Okada, S. Sato, A. Sato, Y. Inoue, T. Yabe, H. Kiyono; Tokyo, Japan 040 P1.03.40 - Expression of Ly6C defines two subsets of mature mouse NK cells Ai Omi, T. Kiniwa, Y. Enomoto, A. Miyajima; Bunkyo-ku, Tokyo, Japan 041 P1.03.41 - Cervical cancer cells treated with EGCG inhibitor induces changes in IFN-gamma, TNF-alpha and perforin secretion in NK-92 cells Pablo C. Ortiz-Lazareno, A. Bravo-Cuellar, P. Gomez-Lomeli, G. Hernandez-Flores, J.R. Dominguez-Rodriguez, L.F. Jave-Suarez, A. Aguilar-Lemarroy; Guadalajara, Mexico 042 P1.03.42 - Multidisciplinary approaches to enhance BRAF targeted therapy in Melanoma Pradeepa Narayana Pangigadde, T. Tan, S. Ferrone, K. Karre, F. Colucci, E. Carbone; Stockholm, Sweden 043 P1.03.43 - KIR2DS1-dependent acquisition of CCR7 and migratory properties by human NK cells interacting with allogeneic HLA-C2+ DC or T cell blasts SIlvia Pesce, S. Sivori, S. Carlomagno, L. Moretta, A. Moretta, E. Marcenaro; Genova, Italy 044 P1.03.44 - Regulation of NKG2D and DNAM-1 ligand expression in HCMV infected fibroblasts: role of the DNA damage response pathway and of viral replication Benedetta Pignoloni, V. Dell’Oste, G. Gribaudo, M. Cippitelli, G. Malgarini, C. Fionda, A. Zingoni, S. Landolfo, A. Santoni, C. Cerboni; Rome, Italy 045 P1.03.45 - Deletion of IL-33 receptor reduces NK cell and CD8 T cell responses to herpesvirus infection Branka Popovic, M. Milovanovic, A. Krmpotic, M. Lukic, S. Jonjic; Rijeka, Croatia 046 P1.03.46 - Down-regulation of the NKG2D receptor is differentially controlled by MICA and ULBP2 ligands Linda Quatrini, R. Molfetta, F. Gasparrini, C. Capuano, A. Zingoni, R. Galandrini, A. Santoni, R. Paolini; Rome, Italy 047 P1.03.47 - Expression of ligands for NK cell receptors NKG2D and DNAM-1 on drug-induced senescent Multiple Myeloma cells depends on redox signaling Biancamaria Ricci, A. Soriani, M. Iannitto, C. Fionda, M. Cippitelli, S. Morrone, M. Petrucci, M. Ricciardi, A. Santoni; Rome, Italy 048 P1.03.48 - Tumour-Priming of Natural Killer Cells May S. Sabry, M.W. Lowdell; London, United Kingdom 049 P1.03.49 - Association of activating kir genes with the late-onset crohn’s disease Suzanne Samarani, D. Mack, C. Bernstain, C. Deslandres, C. Faure, D. Amre, A. Ahmad; Montreal, Canada 050 P1.03.50 - In vitro culture with IL-15 increases NK cell degranulation and enhances NK cell-mediated dendritic cell maturation B. Sanchez-Correa, J.M. Bergua, C. Campos, M.J. Arcos, H. Bañas, S. Morgado, S. Sanchez Mateos, J.J. Gordillo, J.G. Casado, Raquel Tarazona; Caceres, Spain 051 P1.03.51 - Immunosuppressed pre-metastatic niches are caused by hypoxic tumour-derived factors Jaclyn Sceneay, M.T. Chow, D.D.L. Bowtell, M.J. Smyth, A. Moeller; Melbourne, Australia 052 P1.03.52 - Characterization of activated and expanded natural killer cells for the use in cancer therapy M. Granzin, S. Müller, B. Gerstmayer, S. Tomiuk, A. Jacobs, B. Wollscheid, V. Huppert, Jürgen Schmitz; Bergisch Gladbach, Germany 053 P1.03.53 - Conserved cellular miRNA-viral mRNA interactions in influenza A/H1N1: a bioinformatical approach Einat Seidel, M. Seidel, O. Mandelboim; Jerusalem, Israel 054 P1.03.54 - Improvement of NK cells functional activation after long-term IL-2 stimulation in vitro from ovarian neoplasia patients Rodrigo F. Silva; Campinas, Brazil 055 P1.03.55 - Role of HLA-I molecules on NK cells’ phenotype and functions Marwan C. Sleiman, N. Brons, T. Kaoma, F. Bernardin, J. Zimmer; Luxembourg, Luxembourg 056 P1.03.56 - Impairment of natural killer cell function in HIV-1 infected individuals from Brazil Luana S. Soares, M.S. Espíndola, L.J.G. Lima, M.C. Cacemiro, C. Fontanari, L.H. Faccioli, S.K. Haddad, V.R. Bolela, F.G. Frantz; Ribeirao Preto, Brazil 057 P1.03.57 - Influence of age and pro-inflammatory state on the frequency of NK cells subpopulations C. Campos, A. Pera, B. Sanchez-Correa, S. Morgado, I. López, C. Alonso, R. Tarazona, Rafael Solana; Cordoba, Spain 233 Posters - August 27 058 P1.03.58 - NKG2D ligand expression in glomeruli correlates with renal NK cell infiltration in the MRL mouse model Roberto Spada, S. Perez, D.F. Barber; Madrid, Spain 059 P1.03.59 - Phenotypic and functional characterization of the CD56dimCD16lowNK cell subset in bone marrow and peripheral blood of healthy donors Helena Stabile, S. Morrone, D. Pagliara, F. Locatelli, A. Santoni, A. Gismondi; Rome, Italy 060 P1.03.60 - CD28 and CTLA-4 are expressed by mouse NK cells and differentially control NK cell IFN-γ production in response to mature dendritic cells Ana Stojanovic, N. Fiegler, M. Brunner-Weinzierl, A. Cerwenka; Heidelberg, Germany 061 P1.03.61 - CRACC-CRACC interaction enhances NK cell-mediated liver injury via Kupffer cells Rui Sun, Y. Li, Z. Tian; Hefei, China 062 P1.03.62 - Immunoregulatory effects of Natural Killer cells in Multiple Sclerosis Ilhan Tahrali, U. Kucuksezer, E. Aktas Cetin, N. Okumus Akdeniz, A. Yilmaz, U. Uygunoglu, A. Altintas, G. Deniz; Istanbul, Turkey 063 P1.03.63 - NK cell degranulation against human melanoma cell lines is correlated with the expression of NKG2D ligands S. Morgado, B. Sanchez-Correa, J.G. Casado, F. Sierra, E. Durán, S. Sanchez Mateos, J.J. Gordillo, A. Pera, R. Solana, Raquel Tarazona; Caceres, Spain 064 P1.03.64 - Phenotypic Evaluation of NK and NKT-like cells in peptic ulcer and gastric adenocarcinoma caused by Helicobacter pylori infection Mohsen Tehrani, A. Ajami, M. Shadman, A. Rafiei, H. Hussein-Nattaj, V. Hosseini, T. Taghvaei, H. Mesali, H. Asgarian; Sari, Iran, Islamic Republic of 065 P1.03.65 - Fluorescent tagged NK cell receptors expressed in vivo using retrogenic mice to study the delivery of signals in NK cells David Tomaz, N. Guerra, J. Dyson, K. Gould; London, United Kingdom 066 P1.03.66 - MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells Pinchas Tsukerman, O. Mandelboim; Jerusalem, Israel 067 P1.03.67 - Phenotypic and functional assays based on NK cells to address the diagnosis of X-linked lymphoproliferative disease 1 Claudia Tuberosa, R. Meazza, M. Falco, V. Cetica, C. Bottino, M. Aricò, M. Mingari, A. Moretta, L. Moretta, D. Pende; Genoa, Italy 068 P1.03.69 - The human cytomegalovirus induces the CEACAM1 expression to escape immune elimination Alon Vitenshtein, O. Mandelboim; Jerusalem, Israel 069 P1.03.70 - The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity through the lytic synapse formation Toyoshi Yanagihara, Y. Sakai, Y. Tanaka, Y. Fukui; Fukuoka city, Japan 070 P1.03.71 - Dimerization of NKp46 receptor is essential for NKp46-mediated lysis: characterization of the dimerization site by epitope mapping Rami Yossef, M. Jaron-Mendelson, A. Porgador; Beer-Sheva, Israel P1.05 INNATE LYMPHOCYTES Session Time: Tuesday, August 27, 13:20 - 15:00 071 P1.05.01 - Role of γδ T cells in neuronal injury Katja Derkow, C. Krüger, S. Lehnardt; Berlin, Germany 072 P1.05.02 - IL-22 promotes bacteria-driven colon cancer Fanny Franchini, S. Kirchberger, N. West, D.J. Royston, F.M. Powrie; Oxford, United Kingdom 073 P1.05.03 - B1 cells provide immunosurveillance of healthy and inflamed skin Skye A. Geherin, M.H. Lee, R.P. Wilson, G.F. Debes; Philadelphia, United States 074 P1.05.04 - Activating receptor engagement elicits inflammatory signatures in RORγt+ innate lymphoid cells Timor Glatzer, M. Killig, I. Ommert, M. Luetke-Eversloh, M. Babic, D. Paclik, J. Gröne, J. Meisig, K. Stölzel, C. Romagnani; Berlin, Germany 075 P1.05.05 - The regulatory effect of IL-4 on the anti-tumor immune response mediated by human γδ T cells Y. Mao, J. Zhang, Y. Hu, L. Cui, N. Kang, Wei He; Beijing, China 076 P1.05.06 - Intestinal epitherial NK cells produce α-defensin, but convetional NK cells do not Tetsuji Hori, N. Nagaoka, M. Yamamoto, M. Ando, S. Matsumoto; Tokyo, Japan 234 Posters - August 27 077 P1.05.07 - TCRγδ signal activation is required to overcome inhibition by ubiquitin ligase Cbl-b during γδT cell cytotoxicity S. Yin, J. Zhang, L. Cui, Y. Hu, Ning Kang, W. He; Beijing, China 078 P1.05.08 - Innate lymphoid cells mediate IL-33 dependent fibrosis Tamar Mchedlidze, S. Pflanz, M. Schuchmann, M. Neurath, S. Wirtz; Erlangen, Germany 079 P1.05.09 - Morphologic, flow cytometric, functional, and molecular analyses of S100B positive lymphocytes, unique cytotoxic lymphocytes containing S100B protein Yukari Miki, Y. Gion, Y. Mukae, A. Hayashi, K. Takahashi; Kagawa, Japan 080 P1.05.10 - Type I Interferon signaling in a mouse de novo glioma model Takayuki Ohkuri, A. Ghosh, A. Kosaka, J. Zhu, M. Ikeura, S.C. Watkins, H. Okada, S.N. Sarkar; Pittsburgh, United States 081 P1.05.11 - Insight into interaction innate immune response: Role for Asn40Asp allele of OPRM1 gene Anuradha Pal, S. Kapur; Hyderabad, India 082 P1.05.12 - Human B-1 cell frequency and aging from cord blood to the elderly Ali A. Pourfathollah, M. Jazayeri; Tehran, Iran, Islamic Republic of 083 P1.05.13 - An innate-like CD4+ T cell expressing complement receptor 1 Brian Reilly, K. Rasberry, J. Atkinson; Lubbock, United States 084 P1.05.14 - The C-terminal region of the Activation Induced Cytidine Deaminase (AID) is required for the gene conversion and mediates the end joining during class switch recombination Somayeh Sabouri, M. Kobayashi, T. Honjo; Kyoto, Japan 085 P1.05.15 - HIV infection inhibits the crosstalk between monocytes-derived dendritic cells and Vγ9 2δ cells Alessandra Sacchi, N. Tumino, R. Casetti, A. Rinaldi, F. Turchi, F. Martini; Rome, Italy 086 P1.05.16 - Type 2 Innate Lymphoid cells (ILC2) reside in the human skin and contribute to atopic dermatitis Maryam Salimi, J.L. Barlow, S.P. Saunders, L. Xue, D. Gutowska-Owsiak, X. Wang, D. Johnson, S.C. Scanlon, A.N.J. McKenzie, P.G. Fallon, G.S. Ogg; Oxford, United Kingdom 087 P1.05.17 - The role of gamma-delta T lymphocytes in the switch of Ig isotypes in B-1 cells under the influence of TI-2 antigens Nadezda Snegireva, M. Gavrilova, E. Sidorova; Moscow, Russian Federation 088 P1.05.18 - Innate protective responses of B1 cells dependent on activation-induced cytidine deaminase (AID) and interleukin-13 Natsuo Yamamoto, N. Nakazawa, S. Kerfoot, C. DelaCruz, M. Majewska-Szczepanik, M. Szczepanik, Y. Abe, N. Ohana, K. Kanemitsu, P. Askenase; Fukushima, Japan P1.12 LECTINS AND GLYCOIMMUNOLOGY Session Time: Tuesday, August 27, 13:20 - 15:00 089 P1.12.01 - The interaction of complement-activating lectins with Mycobacterium tuberculosis Marcin A. Bartlomiejczyk, A.S. Swierzko, A. Brzostek, J. Dziadek, M. Cedzynski; Lodz, Poland 090 P1.12.02 - Pseudo-mannosylated compounds inhibit DC-SIGN mediated HIV infection by competitive inhibition and by interfering with DC-SIGN signal Angela Berzi, N. Varga, P. Antonazzo, I. Cetin, M. Biasin, D. Trabattoni, A. Bernardi, M. Clerici; Milan, Italy 091 P1.12.03 - Treatment with interferon beta-1a reduces alpha-2,3-sialylation of CD4+ helper T cells J. Piel, K. Friebe, Felix Bischof; Tübingen, Germany 092 P1.12.04 - Jacalin has distinct immunomodulatory effects on early and late stages of experimental colon carcinogenesis Gabriela S. Bisson, T.H. Geraldino, P. Modiano, L.C. Veronez, R.O. Lopes, S.B. Garcia; Ribeirão Preto, Brazil 093 P1.12.05 - The change in the glycosylation of human leukocytes in immunosuppressive environment Katarzyna Bocian, E. Pocheć, M. Dolińska, G. Korczak-Kowalska; Warsaw, Poland 094 P1.12.06 - Anti-Polygalacturonic acid antibodies in diagnosis and pathogenesis of rheumatoid arthritis Hui Dai, X. Gao; Beijing, China 095 P1.12.07 - Interaction of Siglec-7 and -9 with their ligands inhibit NK cell anti-tumor immune responses Kayluz Frias Boligan, C. Schneider, O. Chijioke, C. Jandus, C. Münz, S. von Gunten; Bern, Switzerland 235 Posters - August 27 096 P1.12.08 - Dectin-1 expressed on human pulmonary epithelial cells is an important pattern recognition receptor for the detection of nontypeable Haemophilus influenzae Kerstin A. Heyl, T.E. Klassert, B.B. Singer, A. Heinrich, M.M. Müller, R. Bals, H. Slevogt; Jena, Germany 097 P1.12.10 - CLEC4F is a Kupffer Cells-Specific C-type Lectin Induced in F4/80-positive Cells upon Entry to Liver Shie-Liang E. Hsieh; Taipei, Taiwan 098 P1.12.11 - Characterization of carbohydrate preference of SIGNR1 as pathogen uptake receptor using carbohydratecoated liposomes Yoko Kawauchi, N. Kojima; Hiratsuka, Japan 099 P1.12.12 - The role of membrane lectins from subcellular fractions of human prostate in intracellular transformation at different pathologies Nino Kvitsinadze, I. Megrelishvili, R. Solomonia, E. Davitashvili; Tbilisi, Georgia 100 P1.12.13 - The C-type lectin receptor SIGN-R3 binds to commensal microbiota and influences immune regulation in experimental colitis M. Eriksson, T. Johannssen, D. von Smolinski, A.D. Gruber, P.H. Seeberger, Bernd Lepenies; Potsdam, Germany 101 P1.12.14 - Role of galectin-7 in psoriasis by regulating the skin inflammatory response through keratinocytes Chia-Hui Lo, C. Yen, H. Chen, Y. Lo, H. Chen, F. Liu; Taipei, Taiwan 102 P1.12.15 - R-MC 17 antigen - a rat homologue of DEC-205 antigen? Ivana Majstorovic, D. Vucevic, V. Ilic, S. Gasic, B. Draskovic-Pavlovic, M. Colic; Belgrade, Serbia 103 P1.12.16 - Mannose receptor plays a key role in Th1 polarization of Lactobacillus acidophilus NCFM stimulated dendritic cells Ronja Mathiesen, L. Henningsen, E. Fuglsang, H. Frøkiær; Copenhagen, Denmark 104 P1.12.18 - Increased sialylation of a recombinant IgG mutant produced in human embryonic kidney 293 (HEK293) cells Yusuke Mimura, K. Ronan, L. Unwin, S. Albrecht, Y. Mizukami, M. Goodall, T. Matsumoto, R. Jefferis, P.M. Rudd; Ube, Japan 105 P1.12.19 - C-type lectin receptor Mincle and MCL mediate acquired immunity induced by mycobacterial glycolipid TDM Daiki Mori, Y. Miyake, K. Toyonaga, Y. Yoshikai, S. Yamasaki; Fukuoka, Japan 106 P1.12.20 - Anti-inflammatory drugs from bugs: Mycobacterium tuberculosis gives us a hand E. Blattes, A. Vercellone, H. Eutamène, C. Turrin, V. Théodorou, J. Majoral, A. Caminade, J. Prandi, Jérôme Nigou, G. Puzo; Toulouse, France 107 P1.12.21 - Galectin-3 regulates dendritic cell responses and hematopoietic cell mobilization during acute peritonitis induced by pristane Felipe L. Oliveira, C. Brand, D. Hsu, L. Fu-Tong, R. Borojevic, R. Chammas, M.C. El-Cheikh; Rio de Janeiro, Brazil 108 P1.12.22 - Galectin-8 knockout mice have sex-dependent altered homeostasis of t and b lymphocytes and autoimmune features Evelyn Pardo, D. Valenzuela, A. Soza, A. González; Santiago, Chile 109 P1.12.23 - The binding specificity of H. pylori LPS to DC-SIGN receptor Karolina Rudnicka, E. Miszczyk, A. Matusiak, M. Chmiela; Lodz, Poland 110 P1.12.24 - Galectin-3 plays a role in murine NK cell-mediated INF-γ production E. Kim, B. Choi, J. Lee, Hee-Jong Woo; Seoul, Korea, Republic of 111 P1.12.25 - The MBL paradox: is functional MBL deficiency may be advantageous Tatjana Zaharov; Odense C, Denmark P2.07 PERIPHERAL TOLERANCE AND LYMPHOCYTE ANERGY Session Time: Tuesday, August 27, 13:20 - 15:00 112 P2.07.01 - Anergy in CLL B lymphocytes: implications for the biology and the therapy of the disease Benedetta Apollonio, S. Cristina, M. Bertilaccio, E. ten Hacken, L. Scarfò, F. Stevenson, G. Packham, P. Ghia, M. Muzio, F. Caligaris Cappio; Milano, Italy 113 P2.07.02 - Immune regulation mediated by soluble MHC-II targeting CD4+ T-cells Katerina Bakela, M. Grigoriou, P. Petroulakis, E. Gizeli, I. Athanassakis; Heraklion, Greece 236 Posters - August 27 114 P2.07.03 - Hepatocyte growth factor attenuates in vitro murine cytotoxic T-lymphocyte activity Mahdia Benkhoucha, N. Molnarfi, G. Schneiter, R. Vuilleroy De Silly, P. Walker, P. Lalive; Geneva, Switzerland 115 P2.07.05 - T cell receptor modulation in peripheral CD8 T cells to influenza infection Pradyot Dash, J.L. McClaren, P.C. Doherty, P.G. Thomas; Memphis, United States 116 P2.07.06 - Activation induced split anergy: a mechanism for persistence of autoimmune T cells Shweta Dubey, R.R. Singh; Noida, India 117 P2.07.07 - Ectopic expression of IL-35Ig by dendritic cells induces IDO-related tolerance in vivo Marco Gargaro, M. Belladonna, C. Volpi, R. Bianchi, F. Fallarino, C. Orabona, M. Pallotta, D. Matino, U. Grohmann, P. Puccetti; Perugia, Italy 118 P2.07.08 - Abnormal transcriptional regulation of the E3 ligase Cbl-b by early growth response genes 2 and 3 in systemic lupus erythematosus patients D. Gomez-Martin, J. Romo-Tena, K. Santana-de Anda, Jorge Alcocer-Varela; Mexico city, Mexico 119 P2.07.09 - Olfactory exposure to Tokishakuyaku-san (TJ-23) prolonged cardiac allograft survival and generated regulatory cells Xiangyuan Jin, M. Uchiyama, Q. Zhang, L. Yu, M. Niimi; Tokyo, Japan 120 P2.07.10 - Combination of anti-BTLA antibody (6B2) and anti-PD-1 antibody (PIM-2) induced indefinite survival of fully MHC-mismatched murine cardiac allograft Xiangyuan Jin, M. Uchiyama, L. Yu, H. Bashuda, H. Yagita, M. Niimi; Tokyo, Japan 121 P2.07.11 - Tolerogenic human IL-10-modulated dendritic cells as inducers of regulatory T cells: analysis of mature CD83highCCR7highHLA-DRhigh and immature CD83lowCCR7negativeHLA-DRlow DC subpopulations Fanny Kryczanowsky, E. Graulich, K. Rost, K. Steinbrink; Mainz, Germany 122 P2.07.12 - A humanized mouse model for the study of B cell tolerance in human lymphocytes Julie Lang, M. Kelly, D. Nemazee, B. Freed, R. Torres, R. Pelanda; Denver, United States 123 P2.07.13 - Serial transfere of anergy status induced by TSST-1 into newly stimulated T cells Naoko Negishi, T. Sato, Y. Kametani, S. Hori, K. Okumura, S. Habu; Tokyo, Japan 124 P2.07.14 - The role of GRAIL in anti-cancer immune responses Roza Nurieva, J. Wang, A. Sahoo, A. Alekseev; Houston, United States 125 P2.07.15 - The soluble cytoplasmic tail of CD45 (ct-CD45) induces a non-canonical form of anergy in human T cells Alexander E. Puck, M. Seyerl, S. Hopf, O. Majdic, G. Zlabinger, J. Leitner, P. Steinberger, J. Stöckl; Vienna, Austria 126 P2.07.16 - Characterization of the molecular regulatory pathways involved in MDSC-mediated tolerance Samantha Solito, L. Pinton, V. Damuzzo, L. Perilli, G. Basso, P. Zanovello, V. Bronte, S. Mandruzzato; Padova, Italy 127 P2.07.17 - PD-L1 expression induced by the 2009 pandemic influenza A (H1N1) virus impairs the human T cell response Nuriban Valero-Pacheco, L. Arriaga-Pizano, E. Ferat-Osorio, R. Pastelin-Palacios, M. Villasís-Keever, C.M. Alpuche-Aranda, L.E. Sánchez-Torres, A. Isibasi, L.C. Bonifaz, C. López-Macías; Mexico City, Mexico 128 P2.07.18 - Induction of allogeneic immune tolerance by simultaneously blocking ICOS and OX40 costimulatory pathways Yu-liang Wang; Tianjin, China P3.02 ROLE OF THE STROMA IN INNATE AND ADAPTIVE IMMUNITY Session Time: Tuesday, August 27, 13:20 - 15:00 129 P3.02.01 - Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo A.R. Ribeiro, P. Rodrigues, C. Meireles, J.P. Di Santo, Nuno L. Alves; Porto, Portugal 130 P3.02.02 - Host-derived osteopontin drives the metastatic spread of breast cancer tuning the immunesuppressive microenvironment of the lung niche Claudia Chiodoni, C. Tripodo, S. Sangaletti, I. Torselli, M.P. Colombo; Milan, Italy 131 P3.02.03 - In vivo evidence on mesenchymal stromal cells modulates the lymphomyeloid lineage commitment Shiu-Huey Chou; New Taipei City, Taiwan 132 P3.02.04 - Thymic Nurse Cells from diabetic mice present phenotypic and functional alterations and express leptin receptor Carolina Francelin, R. Di Gangi, I. Geniseli, P. Nagib, J. Gameiro, T. Alves da Costa, R. Thomé, D. Villa-Verde, L. Verinaud; Campinas, Brazil 237 Posters - August 27 133 P3.02.05 - CD49b regulates the establishment and maintenance of T helper cell memory Asami Hanazawa, K. Tokoyoda; Berlin, Germany 134 P3.02.06 - Effects on vaccine memory after Doxorubicin treatment of healthy Rhesus Macaques Hanna Ingelman-Sundberg, S. Eksborg, K. Haanstra, M. Jonker, A. Nilsson; Stockholm, Sweden 135 P3.02.07 - Expression of IL-4 Receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma Frank Kirstein, W.G.C. Horsnell, A.L. Lopata, D. Kuperman, D.J. Erle, F. Brombacher; Cape Town, South Africa 136 P3.02.08 - Skin-resident fibroblasts create unique niches for regulating ATP-mediated mast cell activation Yosuke Kurashima, T. Amiya, K. Fujisawa, S. Sato, Y. Kogure, J. Kunisawa, H. Kiyono; Tokyo, Japan 137 P3.02.09 - PI3K p110δ controls stromal cell distribution and is expressed in gp38+ stromal cells in secondary lymphoid organs T.M. Zotes, S. Pérez-Yagüe, Roberto Spada, C.O. Sorzano, K. Okkenhaug, B. Vanhaesebroeck, A.C. Carrera, D.F. Barber; Cantoblanco (Madrid), Spain 138 P3.02.10 - Prostate cancer-associated stroma induces immunosuppressive monocytes Lisa K. Spary, J. Salimu, M.D. Mason, Z. Tabi; Cardiff, United Kingdom 139 P3.02.11 - Analysis of tumor microenvironment and immune responses against cancer stem cells and application to cancer immunotherapy Toshihiko Torigoe, Y. Hirohashi, R. Morita, K. Yasuda, A. Takahashi, T. Kanaseki, N. Sato; Sapporo, Japan - Moved to August 26 in P5.20: Tumor immunity and immunosurveillance 140 P3.02.12 - Aggregates of B cells and platelet MPs circulate in the human peripheral blood Fatemeh Yari, M. Esmaeili, Z. Sharifi, M. Nikougoftar; Tehran, Iran, Islamic Republic of P3.10 TH17 CELLS Session Time: Tuesday, August 27, 13:20 - 15:00 141 P3.10.01 - New light of the il23/th17 in pemphigus foliaceus Olfa Abida, S. Krichen-Makni, D. Bouzid, A. Masmoudi, M. Abdelmoula, M. Ben Ayed, T. Sellami-Boudawara, H. Turki, H. Masmoudi; Sfax, Tunisia 142 P3.10.02 - Differential mucosal expression of Th17 related genes between inflamed and non-inflamed colon of patients with Crohn’s disease Ahmed Abidi, N. Lidiraa, M. Fekih, N. Ben Mustapha, K. Hamdi, B. Neili, A. Gati, A. Filali, A. Ben Ammar-Elgaaied, R. Marrakchi; Tunis, Tunisia 143 P3.10.03 - The role of β2 adrenergic receptor signaling during the reciprocal differentiation of Th17 and Foxp3+ Treg cells Leandro P. Araujo, M.G. Guereschi, M.C. Takenaka, V.M. Nascimento, J.T. Maricato, A.S. Basso; São Paulo, Brazil 144 P3.10.04 - Regulation of cytokine gene expression in human T helper cells: role of IL-2 and pSTAT5 in the activation-dependent down-regulation of IL-17 production Dominik Aschenbrenner, F. Mele, A. Lanzavecchia, F. Sallusto; Bellinzona, Switzerland 145 P3.10.05 - Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4 Manuela Capone, L. Cosmi, L. Maggi, V. Santarlasci, V. Querci, F. Liotta, P. Parronchi, E. Maggi, S. Romagnani, F. Annunziato; Florence, Italy 146 P3.10.07 - Role of Notch receptor signaling in CD4+ T helper 1 and T helper 17 cell differentiation Manuel Coutaz, F. Auderset, S. Schuster, F. Radtke, F. Tacchini-Cottier; Epalinges, Switzerland 147 P3.10.08 - Defective Th17 development in human neonatal T cells involves reduced RORC2 mRNA content Sytze De Roock, A. Stoppelenburg, R. Scholman, S. Hoeks, J. Meerding, B. Prakken, M. Boes; Utrecht, Netherlands 148 P3.10.09 - Phagocytosis of different source of infected apoptotic cells: does a trigger to Th17 or Th1 differentiation? Naiara N. Dejani, F.F. Verdan, V.E. Nino, F.N. Dias, A.C.G. Salina, A.I. Medeiros; Ribeirao Preto, Brazil 149 P3.10.10 - Cytokine regulation of immunopathology in Echinococcus multilocularis X. Ma, L. Luo, Jian B. Ding, Y. Zhu, N. Pang, H. Wen; Urumqi,Xinjiang, China 150 P3.10.11 - Pharmacological modulation of epigenetic regulation of Treg and Th17 differentiation in vitro Macarena Fritz, C. Doñas, V. Manriquez, G. Tejon, M. Bono, A. Loyola, M. Rosemblatt; Santiago, Chile 151 P3.10.13 - Transfection of human naïve CD4+ T-cells with mir-326 and study of their differentiation to Th-17 cell Mojgan Ghayedi, P. Rahimzadeh, S. Morteza Gholi, H. Namdari, F. Noorbakhsh, E. Salehi; Tehran, Iran, Islamic Republic of 238 Posters - August 27 152 P3.10.14 - Activation of TGF-β-induced non-Smad signaling pathways during Th17 differentiation Steffen Haupeltshofer, M. Hasan, B. Neumann, K. Angstwurm, R. Gold, I. Kleiter; Bochum, Germany 153 P3.10.15 - The aryl hydrocarbon receptor: differential contribution to Th17 and Tc17 development Mark D. Hayes, V. Ovcinnikovs, I. Kimber, R.J. Dearman; Manchester, United Kingdom 154 P3.10.16 - T cell-dependent IgA induction by plastic Th17 cells Keiji Hirota, M. Villa, J. Turner, J.H. Duarte, J. Demengeot, O.M. Steinmetz, B. Stockinger; London, United Kingdom 155 P3.10.17 - A novel assay format for ELISA measurement of antigen-specific human IL-21 production by peripheral mononuclear cells Jenny Y. Huang, C. Ehrnfelt, T. Bengtsson, S. Paulie, N. Ahlborg; Stockholm, Sweden 156 P3.10.18 - Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine Hisako Kayama, T. Kusu, K. Takeda; Suita, Japan 157 P3.10.19 - Human Th17 cells: a unique cell type in health and disease Kerry Ko, M.S. Powell, E. Orlowski, S. Prickett, D. Krumbiegel, P. Hogarth; Melbourne, Australia 158 P3.10.20 - Therapeutic effect of RORγt-DNA-binding domain in TH17-mediated Autoimmune diseases Sang Kyu Lee, T. Park, S. Park, J. Cho, N. Kim; Seoul, Korea, Republic of 159 P3.10.21 - Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells Alessio Mazzoni, L. Maggi, V. Santarlasci, M. Capone, M. Rossi, V. Querci, F. Liotta, E. Maggi, L. Cosmi, F. Annunziato; Florence, Italy 160 P3.10.22 - Discovery of potent and selective retinoid related orphan receptor gamma (ROR-Gamma) inverse agonists for the treatment of Th17 mediated diseases Kavitha Nellore, M. Bejugam, A. Ramanathan, S. Mukherjee, A. Lakshminarasimhan, S.S. Dodheri, N. Rao, R. Damarla, S. Samajdar, H. Subramanya; Bangalore, India 161 P3.10.23 - Unravelling the transcriptional circuit regulating IL-10 production in human Th17 cells Samuele Notarbartolo, D. Aschenbrenner, A. Lanzavecchia, F. Sallusto; Bellinzona, Switzerland 162 P3.10.24 - Differential regulation of T cell responses and disease severity by mycoplasma and its superantigen in autoimmune diabetic mice Maziar M. Nourian, H. Mu; Salt Lake City, United States 163 P3.10.25 - Th17 and IL17 expression in Autoimmune Polyendocrine Syndrome Type 1 and Addison disease: what’s the difference? Anna Parolo, R. Scarpa, C. Agostini, C. Betterle; Padova, Italy 164 P3.10.26 - The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses M. Meisel, N. Hermann-Kleiter, R. Hinterleitner, T. Gruber, K. Wachowicz, Christa Pfeifhofer-Obermair, F. Fresser, M. Leitges, C. Soldani, A. Viola; Innsbruck, Austria 165 P3.10.27 - IL-17 is predominantly expressed by neutrophils, but Th17 cells are associated with survival in cervical cancer Simone Punt, E. Kritikou, G. Fleuren, E.S. Jordanova, A. Gorter; Leiden, Netherlands 166 P3.10.28 - Characterisation of a population of human CCR6 TH1 cells expressing RORC S.M. Restorick, L. Durrant, M. Voice, P. Moss, S. John Curnow; Birmingham, United Kingdom 167 P3.10.29 - Rarity of human T helper 17 cells is due to retinoic acid orphan receptor-dependent mechanisms that limit their expansion Veronica Santarlasci, L. Maggi, M. Capone, V. Querci, D. Cavalieri, F. Liotta, R. De Palma, E. Maggi, L. Cosmi, F. Annunziato; Florence, Italy 168 P3.10.30 - Disequilibrium of Tregs and TH17 cells in the pathogenesis of autoimmune skin disorder: Pemphigus vulgaris Alpana Sharma, A. Raju, V. Anand, S. Khandpur; New Delhi, India 169 P3.10.31 - Characterization of the immune mechanisms involved in periodontal disease in obese rats Dagmar R. Stach-Machado; Campinas, Brazil 170 P3.10.32 - The histamine H4 receptor mediates inflammation in models of arthritis via inhibition of Th17 Robin L. Thurmond, J.M. Cowden, F. Yu, M. Zhang, P. Ling, S. Nguyen, M. Farahani, J. Zhu, J.P. Riley, P.J. Dunford; San Diego, United States 171 P3.10.33 - IL-2 interferes with CD4+ T cell homing by reducing the expression of the 4 integrin Julia Triebus, D. Engelbert, A. Hamann; Berlin, Germany 239 Posters - August 27 172 P3.10.34 - Infected apoptotic adherent or non-adherent cells instruct DCs to trigger Th17 differentiation Felipe F. Verdan, N. Dejani, V.E. Niño, F.N. Dias, A.C.G. Salina, A.I. Medeiros; Ribeirão Preto, Brazil 173 P3.10.35 - Protein Kinase C θ regulates Th1/Th17 plasticity Katarzyna Wachowicz, N. Kleiter, N. Thuille, G. Baier; Innsbruck, Austria 174 P3.10.36 - Myeloid-derived suppressive cells promote Th17 cell differentiation and IL-17 production Xiang-Yang Wang, H. Yi, C. Guo, X. Yu; Richmond, United States 175 P3.10.37 - Runx1-deficiency in CD4+ T Cells Causes Fatal Autoimmune Inflammatory Lung Disease due to Spontaneous Hyperactivation of Cells Won F. Wong; Kuala Lumpur, Malaysia 176 P3.10.38 - The effects of traditional Chinese medicine type on Th17 cells in chronic hepatitis C patients received antivirval therapy Shimin Wu, Z. Xiaolian; Wuhan, China 177 P3.10.39 - Distinct Th17 inductions contribute to the gender bias in CVB3-induced myocarditis Sidong Xiong, Z. Li, Y. Yue, W. Xu; Suzhou, Jiangsu Province, China 178 P3.10.40 - The predominant Th17 phenotype in gastric cancers may be associated with HLX expression decrease blocking Th1 cell specific T-box transcription factor Z. Su, T. Wang, P. Zhang, X. Ji, Huaxi Xu; Zhenjiang, China 179 P3.10.41 - A probiotic strain of Lactobacillus L casei stimulates gene expression in PBMC in obese people M. Zarrati, Eisa Salehi, F. Shidfar, K. Bidad, F. Najafi, Z. Gheflati, M. Meydani, M. Hosein Zadeh, V. Mofid; Tehran, Iran, Islamic Republic of 180 P3.10.42 - Antagonistic regulation of human Th17 and GM-CSF-producing T helper cells R. Noster, R. Riedel, M. Mashreghi, A. Radbruch, Christina E. Zielinski; Berlin, Germany P3.15 B AND T CELL MEMORY Session Time: Tuesday, August 27, 13:20 - 15:00 181 P3.15.01 - In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator Takahiro Adachi, S. Yoshikawa, H. Karasuyama; Tokyo, Japan 182 P3.15.02 - A triple positive staining to capture B cells expressing anti-tetanus toxoid IgG in human blood Eduardo Aliprandini, W. Quintilio, J. Kalil, S.B. Boscardin, A.M. Moro; São Paulo, Brazil 183 P3.15.03 - Ex vivo analysis of human memory B lymphocytes specific for A and B influenza hemagglutinin by polychromatic flow-cytometry Liliana Alleri, F. Angiolini, F. Buricchi, E. Degl’Innocenti, I. Isnardi, E. Fragapane, G. Del Giudice, F. Castellino, G. Galli, M. Bardelli; Siena, Italy 184 P3.15.04 - Innate signals control the binary cell fate choice between CD8+ effector and memory T cell differentiation via Notch R.A. Backer, C. Helbig, M. Willemsen, A. Kent, A. van Kampen, K. van Gisbergen, J. Magarian Blander, Derk Amsen; Amsterdam, Netherlands 185 P3.15.05 - Optimized fluorescent labeling to identify memory B cells specific for Neisseria meningitidis serogroup B antigens ex vivo N. Nair, E. Faenzi, F. Buricchi, Laura Bonoli, F. Castellino, O. Finco, R. Rappuoli, G. Del Giudice, G. Galli, M. Bardelli; Siena, Italy 186 P3.15.06 - Modulation of heme oxygenase (HO)-1 enzyme activity by metalloporphyrins affects the antiviral T-cell response V. Fortmeier, Carola Bunse, S. Tischer, N. Moraw, C. Figueiredo, E. Zilian, R. Blasczyk, S. Immenschuh, B. Eiz-Vesper; Hannover, Germany 187 P3.15.07 - Pou6f1 is dispensable for mouse T cell development and virus-specific memory CD8+ T cell generation Marlene J. Carrasco-Alfonso, W. Jiang, J. Luckey; Boston, United States 188 P3.15.08 - Unique features of protective cytotoxic T cell response during chronic T. gondii infection Hamlet Chu, N. Shastri, E. Robey; Berkeley, United States 189 P3.15.09 - Dividing and non-dividing CD27low and CD27high human memory B-cells are differently induced depending on the stimulus Antonio Clemente, J. Pons, N. Lanio, N. Matamoros, J.M. Ferrer; Palma de Mallorca, Spain 190 P3.15.10 - Distinct memory T- cell-subsets secrete IFN- and IL2 in response to CD4+ T-cell HIV-1 epitopes from a vaccine candidate A.C.S. Borgo, L. Marti, S.L. Moraes, A. Segurado, L. Fonseca, E.G. Kallas, J. Kalil, E. Cunha-Neto, Simone G. Fonseca; Goiania, Brazil 240 Posters - August 27 191 P3.15.11 - Higher cytotoxic capacity in peripheral blood of sarcoidosis patients Helena Forsslund, T. Enger, D. Lorenz, R. Rao, J. Rahman, A. Eklund, M. Sköld, S. Brighenti, J. Grunewald, J. Wahlström; Stockholm, Sweden 192 P3.15.12 - Interleukin-33 is dispensable for the maintenance of memory CD8 T cells Anja Froehlich, W.V. Bonilla, S. Nakae, D.D. Pinschewer, M. Loehning; Berlin, Germany 193 P3.15.13 - Phenotypic and functional heterogeneity of circulating CD4+ and CD8+ T cell subsets and their age related changes N.D. Marín, M. Rojas, S.C. París, Luis F. García; Medellín, Colombia 194 P3.15.14 - Lung APCs of influenza memory mice challenged with influenza virus contain less virus compared to primary infected mice Kjell-Olov Grönvik, A. Daggfeldt; Uppsala, Sweden 195 P3.15.15 - Single cell tracking reveals the segregation of early memory CD8+ T cells from the effector pool by slowing down cell cycle Ichiko Kinyjo, J. Qin, P. Mrass, C.J. Wellard, M. Tomura, O. Kanagawa, A. Miyawaki, P.D. Hodgkin, W. Weninger; Sydney, Australia 196 P3.15.16 - Molecular mechanisms for memory B-cell development and function Daisuke Kitamura, K. Haniuda, S. Fukao, S. Horiuchi, S. Takatsuka, T. Moutai, T. Nojima; Noda, Chiba, Japan 197 P3.15.17 - Isolation of mouse B cells and T cell subsets in as little as 15 minutes Andy I. Kokaji, V. Posarac, L. Tonelli, J.W. Dixon, D.W. Kellerman, P.T. Morin, S. Clarke, M.A. Fairhurst, K.L. McQueen, T.E. Thomas; Vancouver, Canada 198 P3.15.18 - AID dependent memory response in unimmunized mice Simon Le Gallou, R. Fritzen, J. Weill, C. Reynaud; Paris, France 199 P3.15.19 - In vivo IL-6 inhibition using anti-IL-6 receptor antibodies modulates double negative (CD19+IgD-CD27-) B cells in Rheumatoid Arthritis patients Zafar Mahmood, K. Muhammad, P. Roll, M. Schmalzing, T. Dörner, H. Tony; Würzburg, Germany 200 P3.15.20 - Characterising PI16-positive T helper cells Arunesh P. Mohandas, H. Zola, S. Barry, D. Krumbiegel; Adelaide, Australia 201 P3.15.21 - Functional genomic characterization of murine CD8+ CD103+ tissue resident memory T cells Barbara Molnár-Érsek, E. Buzás, T. Simon, A. Nagy, B. Bagita, A. Falus, Z. Pós; Budapest, Hungary 202 P3.15.22 - Identification of dominant B & T cell epitopes of E2 glycoprotein:a way towards vaccine preparation for chikungunya Pradeep K. Nagar; New Delhi, India 203 P3.15.23 - Comparison of four established cell culture conditions to assess antigen-specific memory B cell responses in humans and nonhuman primates Sathit Pichyangkul, U. Kum-Arb, A. Limsalakpetch, K. Yongvanitchit, E. Angov, E.S. Bergmann-Leitner, R. Im-Erbsin, C. Ockenhouse, C.J. Mason, D.L. Saunders; Bangkok, Thailand 204 P3.15.24 - Evaluation of IgA antibody, Melatonin and Cortisol levels in diurnal and nocturnal colostrum samples from healthy puerperae that delivery by vaginal and caesarean partum Gerlandia N. Pontes, M.M.S. Carneiro-Sampaio, R.P. Markus; São Paulo, Brazil 205 P3.15.25 - High frequency of T memory stem cells precedes T cell immune-reconstitution following human bone marrow transplantation Alessandra Roberto, L. Castagna, S. Gandolfi, P. Tentorio, M. Roederer, D. Mavilio, E. Lugli; Rozzano (MI), Italy 206 P3.15.26 - Regulation of epigenetic modifications for AID-accession to the IgV-locus by histone acetyltransferase activity of GANP in germinal center B-cells Nobuo Sakaguchi, S.K. Singh, M.M.A. Eid, S.A. Almofty, M. Shimoda, K. Maeda; Kumamoto City, Japan 207 P3.15.27 - Expression of TCR transgenic b-chain leads to contraction of T lymphocytes pools with surface phenotypes of effector and central memory cells Yulia Silaeva, A. Kalinina, M. Vagida, L. Khromykh, A. Deikin, T. Ermolkevich, E. Sadchikova, I. Goldman, D. Kazansky; Moscow, Russian Federation 208 P3.15.28 - Modulation of mTOR by Respiratory Syncytial virus and its contribution to CD8 T cells memory differentiation Ana Souza, R. Czepielewski, S. Muraro, B. Porto, M. Cunha, C. Bonorino, R. Stein; Porto Alegre, Brazil 209 P3.15.29 - Tsc2 controls the generation of virus-specific memory CD8 T cells Ryan T. Sowell, M. Rogozinska, A.L. Marzo; Chicago, United States 241 Posters - August 27 210 P3.15.30 - Memory B Cell and Plasma Cell Development in Response to Vaccination David Tarlinton, V. Peperzak, I. Vikstrom, D. Zotos; Parkville, Australia 211 P3.15.31 - Newly identified MHC class I epitopes from common human Adenovirus serotypes to improve diagnostic and therapeutic options in adoptive T-cell therapy Sabine Tischer, C. Bunse, N. Moraw, M. Kramer, A. Heim, R. Geyeregger, R. Blasczyk, B. Maecker-Kolhoff, B. Eiz-Vesper; Hannover, Germany 212 P3.15.32 - Histamer-based selection and separation of functionally active ADV-specific CD8+ T lymphocytes Sabine Tischer, T. Kaireit, N. Moraw, C. Bunse, C. Figueiredo, O. Hiller, B. Maecker-Kolhoff, S. Immenschuh, R. Blasczyk, B. Eiz-Vesper; Hannover, Germany 213 P3.15.33 - Evaluation of B cell subpopulations over time upon immunization against Streptococcus pneumoniae in HIV-1 patients - A 48 week study Olga Tsachouridou, L. Skoura, S. Metallidis, P. Zembekakis, D. Pilalas, A. Margariti, A. Kourelis, N. Malisiovas, P. Nikolaidis; Thessaloniki, Greece 214 P3.15.34 - Blockade or deletion of FcγR2B (CD32) prevents FVIII-specific memory B cells response in Haemophilia A mouse model Nadine Vollack, M. von Hornung, K. Kalippke, A. Trummer, A. Ganser, A. Tiede, S. Werwitzke; Hanover, Germany 215 P3.15.35 - CD8 T cell effector and memory fate decisions are differentially regulated by CD27 and 4-1BB costimulation Jane E. Willoughby, J.P. Kerr, V.Y. Taraban, A. Rogel, S.L. Buchan, P.W. Johnson, A. Al-Shamkhani; Southampton, United Kingdom 216 P3.15.36 - Analysis of factors that induce memory T cells Tomoyoshi Yamano, T. Soh, Y. Oki, K. Fukuda, H. Kishimoto; Munich, Germany 217 P3.15.37 - Identification of T-lymphocyte responses and long-term immunological memory in survivors of ebolavirus infection S. Mulangu, H. Marcus, J. Ledgerwood, N. Kisalu, M. Roederer, R. Koup, B. Graham, J. Muyembe, Nancy J. Sullivan; Bethesda, United States P4.12 MICROBIOME, GUT FLORA AND INFLAMMATION Session Time: Tuesday, August 27, 13:20 - 15:00 218 P4.12.01 - Tuberculosis and acquired immunodeficiency syndrome Elham Beiranvand, S. Abediankenari, M. Rezaei, B. Beiranvand, A. Khalili; Tehran, Iran, Islamic Republic of 219 P4.12.02 - Characterization of commensal bacteria based on their effects on human dendritic cell-induced T-lymphocyte polarization Krisztian Bene, M. Toth, N. Boiko, E. Rajnavolgyi; Debrecen, Hungary 220 P4.12.03 - Staphylococcus aureus affect T-regulatory cell phenotype and FoxP3-expression Sophia Björkander, Y. Haileselassie, L. Hell, S. Roos, U. Holmlund, E. Sverremark-Ekström; Stockholm, Sweden 221 P4.12.04 - Enterococcusdurans EP1 modulates inflammation in a DSS-induced colitis model in mice Paula Carasi, S.M. Racedo, C. Jacquot, M. Serradell, M.C. Urdaci; La Plata, Argentina 222 P4.12.05 - Butyric acid in the gingival tissue induces mitochondrial oxidative stress while acutely increasing caspase-9 activity Marni E. Cueno, K. Imai, N. Matsukawa, T. Tsukahara, K. Ochiai; Tokyo, Japan 223 P4.12.06 - Homology modeling and structural analyses of the six Porphyromonas gingivalis FimA variants Marni E. Cueno, K. Nagano, K. Imai, F. Yoshimura, K. Ochiai; Tokyo, Japan 224 P4.12.08 - The intestinal microbiota triggers epithelial Toll-like receptor expression and impairs neuropilin-1 processing and hedgehog signaling in the small intestinal mucosa Nives Hörmann, J. Hahlbrock, I. Brandao, F. Bäckhed, U. Walter, C. Reinhardt; Mainz, Germany 225 P4.12.09 - Is IutA from Escherichia coli a type 1 Thymus-independent antigen? Taise N. Landgraf, F.F. Fernandes, A.A.M. Coelho-Castelo, A. Panunto-Castelo; Ribeirão Preto, Brazil 226 P4.12.11 - The protective role of the intestinal microbiota in the host defense against Streptococcus pneumoniae-induced pneumonia T. Schuijt, Jacqueline M. Lankelma, T. van der Poll, W.M. de Vos, W.J. Wiersinga; Amsterdam, Netherlands 227 P4.12.12 - Probiotics promote protective immunity against enteric bacteria infection by gut immune maturation Se Na Lee, J. Yang, S. Lee, M. Kweon; Seoul, Korea, Republic of 228 P4.12.13 - Modulation of Enteropathogen-mediated immunity by Sodium Butyrate Enea Milioris, V. Iebba, N.K. Klein, M. Bajaj-Elliott; London, United Kingdom 242 Posters - August 27 229 P4.12.14 - Relation between IL-17 gene polymorphisms and H. pylori associated gastric diseases Ali Moravej, M. Rasouli, A. Kouhpayeh, M. Kalani; Fasa, Iran, Islamic Republic of 230 P4.12.15 - Phenotype and function of lymphocytes in normal and inflamed appendix Ghasem Mosayebi, S. Alizadeh, A. Ghazavi, M. Okhovat; Arak, Iran, Islamic Republic of 231 P4.12.16 - High fat diet impairs respiratory tolerance in a mouse model of allergic asthma Angela Pizzolla, D.Y. Oh, J. Rolland, R. O’Hehir, C. Hardy; Melbourne, Australia 232 P4.12.17 - Link between Western diet and intestinal inflammation: role of TLRs/NLRs Claudia Sardi, P. Luchini, A. Emanuelli, L. Manara, E. Martini, M. Kallikourdis, A. Balsari, C. Rumio; Rozzano, Italy 233 P4.12.18 - Immunoregulatory mechanisms associated with Bifidobacterium infantis 35624 exopolysaccharides Elisa Schiavi, M. Gleinser, P. Konieczna, R. Ferstl, D. Patsch, M. Ziegler, R. Frei, L. O’Mahony; Davos, Switzerland 234 P4.12.19 - Epigenetic control of host genes in intestinal epithelial cells by commensal bacteria Kyoko Takahashi, Y. Sugi, T. Kobayakawa, A. Hosono, S. Kaminogawa; Kanagawa, Japan 235 P4.12.20 - Fibre, short-chain fatty acids and microbiota combat the development of asthma Alison N. Thorburn; Clayton, Australia 236 P4.12.22 - Remodeling of stromal architecture in the gut mucosa as a mirror of immunological changes under various conditions (germ-free animals, colitis and cancer) Luca Vannucci, J. Krizan, O. Chernyavskiy, R. Stepankova, F. Caja, D. Stakheev, L. Rajsiglova, J. Dvorak, P. Rossmann; Prague 4, Czech Republic 237 P4.12.23 - The Microbial Landscape Of Breast Cancer: Examination At The Site Of Disease C. Xuan, J. Shamonki, A. Chung, P.A. Sieling, Delphine J. Lee; Santa Monica, United States 238 P4.12.24 - Synthesis and pharmacological evaluation of 8-substituted phenyl xanthines for asthma therapy Rakesh Yadav, D. Yadav, A. Kuhad, R. Bansal; Banasthali, India 239 P4.12.25 - Comparative fecal microbiome of Holstein and Nelore bovines: differential bacterial composition can be related to susceptibility to ectoparasites Amanda F. Zangirolamo, T.M. Banin, I.K.F.M. Santos, S.R. Maruyama; Ribeirão Preto, Brazil P5.05 ENVIRONMENTAL FACTORS IN AUTOIMMUNITY AND ALLERGY Session Time: Tuesday, August 27, 13:20 - 15:00 240 P5.05.01 - Nutrition has relation with lifetime asthma diagnosis in middle-aged Mahdi Akhbardeh, A. Sadeghi; Hawthorn, United States 241 P5.05.02 - High psychological stress in children may alter the immune response Emma Carlsson, A. Frostell, J. Ludvigsson, M. Faresjö; Jönköping, Sweden 242 P5.05.03 - Infection with the respiratory pathogen Bordetella pertussis modulates the course of experimental autoimmune encephalomyelitis Sarah Edwards, S.C. Higgins, N. McGuinness, K.H.G. Mills; Dublin, Ireland 243 P5.05.04 - Bisphenol A suppresses interferon-gamma production and related biochemical pathways in human PBMC E. Raggl, S. Geisler, H. Schennach, J.M. Gostner, Dietmar Fuchs; Innsbruck, Austria 244 P5.05.05 - Epicutaneous exposure to nanoparticles is potential initiator of IgE-mediated hypersensitivity induced by IgG reduction Toshiro Hirai, Y. Yoshioka, H. Takahashi, K. Ichihashi, N. Nishijima, T. Yoshida, S. Tsunoda, K. Higashisaka, Y. Tsutsumi; Osaka, Japan 245 P5.05.06 - Serum levels of pro-inflammatory cytokines in rats exposed to car exhaust and cigarette smokin Morteza Hosseinzadeh, A. Khosravi, K. Sayemiri, M. Motavali; tehran, Iran, Islamic Republic of 246 P5.05.07 - Autoimmune pulmonary alveolar proteinosis and exposure to industrial spray paint Tasnim Imran, Z. Al-Khateeb, P. Jiang; Newark, United States 247 P5.05.08 - The investigation of prevalence of allergic rhinitis and single nucleotide polymorphisms of STAT6, IL-4R in Xinjiang of China Xiao f. Jiang, G. Li, Y. Qing, D.J. hong, M.N. re, Z. Xiu, L.F. tai; Urumqi, China 243 Posters - August 27 248 P5.05.09 - Immunological analysis of allergic reactions to the carbohydrate α-Gal Dagmar Kollmann, C. Ebner, W. Emminger, A. Mangold, H.J. Ankersmit, B. Bohle; Vienna, Austria 249 P5.05.10 - Both reactive oxygen species and reactive nitrogen species participate in the redox-regulation of toluene diisocyanate-induced lung inflammation Pei-Chi Lo, C. Shieh; Tainan, Taiwan 250 P5.05.11 - Screening for celiac disease in patients with Hashimoto’s thyroiditis S. Hamdane, Amani Mankai, W. Sakly, M. Chadli-Chaieb, I. Ghedira; Tunis, Tunisia 251 P5.05.12 - The influence of Professional Contact to Fungal Allergens on developing Respiratory Allergy Disorders in workers of bakeries in Georgia Nunu Mitskevich, K. Machavariani, A. Telia, G. Khechinashvili; Tbilisi, Georgia 252 P5.05.13 - Lack of association between serotonin transporter gene polymorphisms and asthma Mozhgan Moghtaderi, S. Farjadian, S. Aleyasin, S. Kashef; Shiraz, Iran, Islamic Republic of 253 P5.05.14 - Effect of the indoor air pollutant 2-ethyl-hexanol on immune cells Kentaro Morita, Y. Song, T. Nakanishi, Y. Yoshida; Fukuoka, Japan 254 P5.05.15 - Therapeutic potential of Allium cepa L. and the flavonoid quercetin in an experimental model of respiratory allergy Tatiane Oliveira Teixeira, K. M Dourado, A. Cerqueira-Lima, E. da Silva Velozo, L. C Pontes de Carvalho, N. Maria Alcântara Neves, C. Alexandrina Viana de Figueiredo; Salvador, Brazil 255 P5.05.16 - Characteristics of effector and regulatory T cell subsets in the lungs of smoking and non-smoking healthy individuals Mahyar Ostadkarampour, M. Müller, S. Kullberg, A. Eklund, J. Grunewald, J. Wahlström; Stockholm, Sweden 256 P5.05.17 - Immune markers in oral discomfort patients before and after elimination of oral galvanism Stepan Podzimek, M. Tomka, J. Bartova, J. Prochazkova; Prague, Czech Republic 257 P5.05.18 - Prolonged exposure to type-I IFN inhibits IL-10 signaling in memory and regulatory T cells: a new mechanism contributing to the development of autoimmune diseases Giorgio Raimondi, Y.T. Nicholson, L.C. Chen; Baltimore, United States 258 P5.05.19 - Novel immunoregulatory function of the carcinogen Acrolein: inhibition of allergic sensitization and promotion of tumor growth in BALB/c mice Franziska Roth-Walter, A. Willensdorfer, C. Stremnitzer, C. Schultz, S. Diesner, K. Szalai, J. Fazekas, A. Moskovskich, H. Birnleitner, E. Jensen-Jarolim; Vienna, Austria 259 P5.05.20 - Effect of petrochemical pollutants on Avicennia marina pollens allergenicity Mandana Salehi, Z. Pourpak; Tehran, Iran, Islamic Republic of 260 P5.05.21 - Treatment of patients with severe Pneumonia and Pneumonia associated with Diabetes Tatyana Slavyanskaya, R. Sepiashvili; Moscow, Russian Federation 261 P5.05.22 - From gut immune regulation to self-tolerance: preventing autoimmune diabetes in the gut mucosa Chiara Sorini, V. Usuelli, D. Cavalieri, K. Honda, E. Bosi, M. Falcone; Milan, Italy 262 P5.05.23 - Thymic Atrophy Induced by Malaria Infection Aggravates Experimental Autoimmune Encephalomyelitis (EAE) Rodolfo Thomé, L.K. Issayama, T. Alves da Costa, R.D. Gangi, C. Francelin, A.d. Farias, L.M.B. Santos, L. Verinaud; Campinas, Brazil 263 P5.05.24 - Natural tolerance towards peanuts in African allergic patients Eva Wollmann, E. Sibanda, C. Hamsten, A. Önell, D. Gallerano, C. Lupinek, R. Valenta, M. van Hage; Vienna, Austria 264 P5.05.25 - Resveratrol modulates collagen-induced arthritis by inhibiting Th17 and B-cell function Damo Xu, x. Gao, M. Komai-Koma, B.P. Leung, I.B. McInnes; University of Glasgow, United Kingdom P5.07 ANIMAL MODELS OF AUTOIMMUNITY Session Time: Tuesday, August 27, 13:20 - 15:00 265 244 P5.07.01 - Biochemical studies on glyoxal mediated glycated histones; Implications for presence of serum antibodies against the glycated histones in patients with type 1 diabetes mellitus Nadeem A. Ansari, D. Dash; Lucknow, India Posters - August 27 266 P5.07.02 - Effect of IL-7 on T cell differentiation during autoimmunity Carlos A. Arbelaez; Seattle, United States 267 P5.07.03 - Systemic autoimmunity caused by a chronic innate response to intracellular nucleic acids Rayk Behrendt, B. Hiller, T. Schumann, K. Peschke, M. Achleitner, N. Schubert, R. Naumann, A. Dahl, W. Mueller, A. Roers; Dresden, Germany 268 P5.07.04 - Lack of T-bet does not inhibit dendritic cell ability to initiate an immune response in a dendritic cell driven model of experimental eutoimmune encephalomyelitis Helen E. Cambrook, R.J. Mellanby, R.C. McPherson, D.G. Turner, M.D. Leech, R.A. O’Connor, S.M. Anderton; Edinburgh, United Kingdom 269 P5.07.05 - Genistein derivatives down-modulates pro-inflammatory cytokines in activated J774A.1 cells and reverses clinical signs of experimental autoimmune encephalomyelitis Sandra B.R. Castro, C.O.R. Junior, C. Souza Alves, A.T. Dias, M.A. Juliano, M.C.M.N. Castanon, M.V. Almeida, H.C. Teixeira, A. Ferreira; Juiz de Fora, Brazil 270 P5.07.06 - Genistein modulates TLR3, TLR4 and TLR9 in antigen presenting cells and delayed clinical signs of experimental autoimmune encephalomyelitis A.T. Dias, Sandra B.R. Castro, C. Souza Alves, L.C. Silva, M.G. Evangelista, M.A. Juliano, A. Ferreira; Juiz de Fora, Brazil 271 P5.07.07 - Prolactin levels correlate with abnormal B cell maturation in MRL and MRL/lpr mouse models of systemic lupus erythematosus-like disease Adriana K. Chavez-Rueda, F. Blanco-Favela, M.V. Legorreta-Haquet, R. Flores-Fernandez, L. Chávez-Sánchez; Mexico, Mexico 272 P5.07.08 - Vitamin D does not boost MOG therapeutic effect in experimental autoimmune encephalomyelitis Fernanda Chiuso-Minicucci, S.F.G. Zorzella-Pezavento, L.L.W. ISHIKAWA, T.G.D. França, P.M. Colavite, L.C. Rosa, A. Sartori; Botucatu, Brazil 273 P5.07.09 - Galectin-9 contributes to enhanced experimental autoimmune encephalomyelitis Jinhee Cho, S. Bing, S. An, A. Kim, Y. Jee; Jeju, Korea, Republic of 274 P5.07.10 - Neutrolphils infiltration, increased IL-1 production and SAPHO syndrome-like phenotype in PSTPIP2 deficiency mice I-Tsu Chyuan, H. Liao, C. Wu, M. Yen, H. Tsai, P. Hsu; Hsinchu City, Taiwan 275 P5.07.11 - Induction of SLE-like syndrome in Balb/c mice by immunization with active chromatin Fatemeh Faraji, F. Lavi Arab, M. Mahmoudi, M. Rastin, M. Ghoryani, H. Reihani, D. Haghmorad, R. Nosratabadi, N. Tabasi, S. Zamani Taghizadeh Rabe; Mashhad, Iran, Islamic Republic of 276 P5.07.12 - X-ray irradiation suppresses SLE-like morbidity in NZBWF1 mice Kazuko N. Fujita, B. Wang, T. Kuwabara, K. Tanaka, I. Kamata, Y. Akasaka, T. Ishii; Tokyo, Japan 277 P5.07.13 - Autoantibody repertoire and inflammatory myeloid cell expansion drive the transition from autoreactivity to autoimmunity in a novel mouse model of systemic lupus erythematosus Si-Han V. Hai, V.C. Lam, B. Cook, A. Weiss, M.L. Hermiston; San Francisco, United States 278 P5.07.14 - Specificity of antinuclear antibodies in Swiss Webster mice following exposure to gold salts and mercury Said Havarinasab; Linköping, Sweden 279 P5.07.15 - Effect of mercury (Hg) and silver (Ag) in mice model of autoimmunity- Re-challenging of mice by additional heavy metal exposure leads to acceleration of the autoimmune response Said Havarinasab; Linköping, Sweden 280 P5.07.16 - Human parvovirus B19 NS1 protein aggravates hepatic fibrosis in NZB/W F1 mice Tsai-Ching Hsu, B. Tzang, C. Tsai, C. Chiu; Taichung, Taiwan 281 P5.07.17 - RORγt transgenic mice developed spontaneous sialadenitis like Sjögren’s syndrome Mana Iizuka, H. Tsuboi, H. Asashima, Y. Kondo, S. Takahashi, I. Matsumoto, T. Sumida; Tsukuba, Japan 282 P5.07.18 - Early local IL-12p40/p(40)2 production and intensity of peritoneal inflammation correlate with susceptibility to pristane induced arthritis C. Rossato, L.L. Albuquerque, O.G. Ribeiro, N. Starobinas, M. Spadafora-Ferreira, W.H.K. Cabrera, A. Borrego, O.M. Ibañez, M. De Franco, José R. Jensen; São Paulo, Brazil 283 P5.07.19 - Immune regulation of monophasic experimental autoimmune uveitis influencing relapsing disease Ulrike Kaufmann, M. Diedrichs-Möhring, G. Wildner; Munich, Germany 284 P5.07.21 - Spatial learning and memory impairment in an acute experimental autoimmune encephalomyelitis Dejana Kosanovic, A. Stojkovic, N. Vukov, K. Jovanova-Nesic; Belgrade, Serbia 245 Posters - August 27 285 P5.07.23 - Assessment of vitamin D effects in lupus- like syndrome induced mouse model Fahimeh Lavi Arab, F. Faraji, M. Mahmoudi, M. Rastin, M. Ghoryani, H. Reihani, D. Haghmorad, R. Nosratabadi, N. Tabasi, S. Zamani Taghizadeh Rabe; Mashhad, Iran, Islamic Republic of 286 P5.07.24 - B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes and encephalomyelitis by suppressing Th1 and Th17 cells Ming-Hong Lin, L. Yeh, H. Chiou, S. Fu, K. Lin, S. Chen, D. Chang, H. Sytwu; Taipei, Taiwan 287 P5.07.25 - Dominancy of encephalitogenic peptide itself directs sustainable remission of a model of multiple sclerosis, through later expansion of ‘armoured’ effector regulatory T cells: possibility of vaccination for autoimmune disease Youwei Lin, S. Miyake, T. Yamamura; Tokyo, Japan 288 P5.07.26 - Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γ levels and increased expression of IFN-γ-receptor-1 on B cells Takeshi Machida, N. Sakamoto, K. Honma, T. Matsuyama, K. Yui, H. Sekine; Fukushima, Japan 289 P5.07.27 - Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their maturation program Mitsuru Matsumoto, Y. Nishikawa, Y. Mouri, H. Nishijima; Tokushima, Japan 290 P5.07.28 - Natural killer cells promote induction of experimental autoimmune encephalomyelitis but are protective at the acute stage of disease Niamh Mc Guinness, L.S. Dungan, S. Edwards, S.C. Higgins, M.A. Lynch, K.H.G. Mills; Dublin, Ireland 291 P5.07.29 - Expression of CXCR3 on specific T cells is essential for homing to the prostate gland in an experimental model of autoimmune prostatitis M.L. Breser, Rubén D. Motrich, V.E. Rivero; Córdoba, Argentina 292 P5.07.30 - Analysis of the immune response and the prostate-reactive T cell repertoire in a mouse model of experimental autoimmune prostatitis in NOD mice Ruben D. Motrich, M.L. Breser, V.E. Rivero; Cordoba, Argentina 293 P5.07.31 - Establishment of collagen-induced arthritis in cynomolgus monkeys, a model for rheumatoid Arthritis Jia Ni, J. Liu, J. Deng, G. Cui, L. Le, S. Wang, K. Zhang; Shanghai, China 294 P5.07.32 - Activation of T cells around the blood brain-barrier illuminated by a fluorescent NFAT marker Marija Pesic, I. Bartholomäus, N.I. Kyratsous, V. Heissmeyer, H. Wekerle, N. Kawakami; Martinsried, Germany 295 P5.07.33 - A mouse model for paraneoplastic neurological syndrome: when efficient anti-tumoral immunity leads to autoimmunity in the CNS Béatrice Pignolet, C. Gebauer, G. Martin-Blondel, C. Dalard, S. Desbois-Beaumel, D. Brassat, R.S. Liblau; Toulouse, France 296 P5.07.34 - Induction of systemic lupus erythematosus-like syndrome in BALB/c mice leads to disturbance in peripheral T cell subpopulations Parisa Rahimzadeh, M. Ghayedi, S. Morteza Gholi, H. Namdari, A. Mirshafiey, E. Salehi; Tehran, Iran, Islamic Republic of 297 P5.07.35 - TLR8-deficiency accelerates autoimmunity in a spontaneous lupus mouse model N. Tran, Marie-Laure Santiago-Raber; Geneva, Switzerland 298 P5.07.36 - Conditional mouse model to study the tissue- and time specific effects of NADPH oxidase 2 -derived reactive oxygen species during arthritis Outi Sareila, P. Rantakari, C. Hagert, S. Jalkanen, M. Poutanen, R. Holmdahl; Turku, Finland 299 P5.07.37 - Lack of IRF-1 accelerates development of tubulointerstitial nephritis and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice T. Machida, N. Sakamoto, E. Suzuki, X. Zhang, C. Reilly, G. Gilkeson, Hideharu Sekine; Fukushima, Japan 300 P5.07.38 - Novel anthraquinone derivatives reduce inflammatory cytokines in vitro and ameliorate clinical signs of experimental autoimmune encephalomyelitis Caio Cesar Souza Alves, S.B.R. Castro, C.F. Costa, T.A. Correa, M.V. Almeida, A. Ferreira; Juiz de Fora, Brazil 301 P5.07.39 - The up-regulation of innate immune response can be observed by expression of TLR3, TLR4 and TLR9 by antigen-presenting cells in EAE model M.G. Evangelista, S.B.R. Castro, A.T. Dias, Caio Cesar Souza Alves, M.A. Juliano, A. Ferreira; Juiz de Fora, Brazil 302 P5.07.40 - Mouse SCID Models of Systemic Lupus Erythematosus Andrey I. Tchorbanov, N. Kerekov, N. Mihaylova; Sofia, Bulgaria 246 Posters - August 27 303 P5.07.41 - Reduced disease severity in an APRIL-deficient lupus mouse model Ngoc Lan Tran, M. Santiago-Raber; Geneva, Switzerland 304 P5.07.42 - Effects of Cystamine on CD4+/CD25+ regulatory T cells in lupus-prone mice Bor-Show Tzang, T. Hsu, C. Chiu, Y. Wang; Taichung, Taiwan 305 P5.07.43 - Autoantibody induction by DNA-containing immune complexes requires HMGB1 with TLR2/miR-155 pathway Sidong Xiong, Z. Wen, W. Xu; Suzhou, Jiangsu Province, China 306 P5.07.44 - Differential Modulation of Effector and Regulatory T Cells Leads to Attenuation of Autoimmune Diabetes in Ptpn22 Transgenic Nonobese Diabetic Mice Li-Tzu Yeh; Taipei, Taiwan 307 P5.07.45 - Adoptive cell transfer from multiple low dose streptozotocin diabetic donors can induce diabetes in healthy young C57/BL6 mice Nemanja S. Zdravkovic, S. Pavlovic, M.L. Lukic; Kragujevac, Serbia 308 P5.07.46 - Downmodulation of peripheral MOG-specific immunity by pVAXhsp65 treatment during EAE do not reach the CNS Sofia F.G. Zorzella-Pezavento, F. Chiuso-Minicucci, T.G.D. França, L.L.W. Ishikawa, L.C. Rosa, P.M. Colavite, C. Marques, M.R.V. Ikoma, C.L. Silva, A. Sartori; Botucatu, Brazil P5.14 PSORIASIS AND SKIN DISEASES Session Time: Tuesday, August 27, 13:20 - 15:00 309 P5.14.01 - Genome-wide linkage scan for psoriasis susceptibility loci in multiplex Tunisian families Myriam Ammar, C. Bouchlaka, I. Zaraa, C. Helms, C. Jordan, N. Doss, R. Marrakchi, A. El Gaied, M. Mokni, A. Bowcock; Tunis, Tunisia 310 P5.14.02 - Absence of functional or quantitative defects of peripheral regulatory T lymphocytes in patients with Alopecia areata Ahlem Ben Hmid, N. Belhaj Hmida, M. Mokni, H. Louzir, I. Zaraa, M. Ben Ahmed; Tunis, Tunisia 311 P5.14.03 - Atypical pemphigus Emilio Berti, L. Venegoni, D. Fanoni, L. Lunardon, R. Fiorani, S. Muratori; Milan, Italy 312 P5.14.04 - Neutrophil depletion by two different antibodies in a hapten-induced inflammation model in mice Anne Deen Christensen, S. Skov, C. Haase; Copenhagen, Denmark 313 P5.14.05 - Secretory leukocyte protease inhibitor (SLPI) controls the immunogenicity of DNA deposits in psoriasis Joanna Cichy, J. Skrzeczynska-Moncznik, A. Wlodarczyk, K. Zabieglo, M. Banas, M. Kapinska-Mrowiecka, A. Dubin; Krakow, Poland 314 P5.14.06 - Skin inflammation is induced by weathered marine crude oil exposure J.M. Kemp, L.R. Luckett-Chastain, W.M. McShan, Randle M. Gallucci; Oklahoma City, United States 315 P5.14.07 - The Ying & Yang of p40 in psoriatic plaque formation in mice Stefan Haak, P. Kulig, S. Pantelyushin, G. Gyülvészi, F. Sallusto, B. Reizis, B. Becher; New York, United States 316 P5.14.08 - Essential role of ITAM-Syk-IL-1 axis in skin dendritic cells for the sensitization of allergic contact dermatitis Hiromitsu Hara, S. Yasukawa, H. Yoshida, M. Furue; Saga, Japan 317 P5.14.09 - αE integrin augments Arthus reaction by modulating the function of CD8+ T cells Takafumi Kadono, D. Yamada, Y. Masui, Y. Asano, Y. Tada, M. Sugaya, S. Sato; Tokyo, Japan 318 P5.14.10 - IRF-2 haploinsufficiency and a TLR 7/8 stimulator synergize in the development of psoriasis-like skin inflammation Makiko Kawaguchi, S. Makoto, K. Takayuki, M. Sohshi, S. Hiraku, K. Takafumi, S. Shinichi; Bunkyo-ku, Japan 319 P5.14.11 - High B-cell-activating factor (BAFF) levels in Tunisian pemphigus patients Lilia Laadhar, K. Mejri, M. Kallel Sellami, I. Zarraa, H. Lahmar, M. Mokni, I. Mokhtar, B. Fazaa, M. Zitouni, S. Makni; Tunis, Tunisia 320 P5.14.12 - IgE levels and immune response in bullous pemphigoid and mucous membrane pemphigoid Luisa Lunardon, D. Fanoni, M. Riboldi, F. Vaira, S. Muratori, E. Berti; Milan, Italy 321 P5.14.13 - Keratinocyte-restricted Rabgef1 gene deletion results in the development of lesions resembling atopic dermatitis, as well as systemic inflammation, in vivo Thomas Marichal, L.L. Reber, P. Starkl, S. Tam, M. Tsai, S.J. Galli; Stanford, United States 247 Posters - August 27 322 P5.14.14 - Evidence for vitamin D deficiency and increased prevalence of fractures in autoimmune bullous skin diseases A.V. Marzano, V. Trevisan, C. Eller-Vainicher, P. Beck-Peccoz, C. Crosti, I. Chiodini, Emilio Berti; Milan, Italy 323 P5.14.15 - Expression of pemphigus vulgaris antigen desmoglein 3 on pancreatic cells Elena V. Matushevskaya, A.V. Prokhorov, E.V. Svirshchevskaya; Moscow, Russian Federation 324 P5.14.16 - Activation-induced cytidine deaminase promotes oncogenesis of ultraviolet light-independent squamous cell carcinoma of the skin Taichiro Nonaka, M. Uemura, H. Hiai, N. Minato, T. Honjo, K. Kinoshita; Kyoto, Japan 325 P5.14.17 - Role of Interleukin-1 processing and signaling in imiquimod-induced psoriasis-like skin inflammation Hanitriniaina Rabeony, P. Vasseur, I. Paris, J. Jégou, B. Ryffel, F. Bernard, J. Lecron, F. Morel; Poitiers University, France 326 P5.14.19 - Role and mechanisms of action of fibroblast growth factors in epidermal barrier function: Implications for inflammatory skin disease Jitka Sulcova, E. Guiducci, M. Meyer, M. Kopf, H. Rodewald, S. Werner; Zurich, Switzerland 327 P5.14.20 - Di methyl fumarate (DMF), is there a possibility for broader use in psoriasis treatment? Sahar Tahvili, B. Zandieh, Z. Amirghofran, F. Hanjani; Shiraz, Iran, Islamic Republic of 328 P5.14.21 - An orally bioavailable CCR6 antagonist confers protection against IL17-mediated inflammation Joanne B. Tan, Z. Miao, R. Berahovich, K. Ebsworth, J. Powers, M. Leleti, T. Schall, J. Jaen, M. Walters; Mountain View, United States 329 P5.14.22 - The inhibitory effects of yuzu seed oil to atopic dermatitis model mice by oral administration Ken-ichiro Terashita, Y. Watanabe, K. Asano, K. Yamawaki, S. Aoki, E. Takahashi, M. Toutani, S. Mizobuchi; Nankoku, Japan 330 P5.14.23 - IL-17A-producing CD8+ T cells in psoriasis: correlation with psoriasis severity and relationship with MAIT cell lineage Marcel B.M. Teunissen, N. Yeremenko, D. Baeten, S. Chielie, P.I. Spuls, M.A. de Rie, P.C.M. Res; Amsterdam, Netherlands 331 P5.14.24 - Skin involvement in cutaneous and systemic vasculitis Pamela Vezzoli, A.V. Marzano, E. Berti; Bergamo, Italy 332 P5.14.25 - Topical application of the yuzu seed oil inhibits mite-antigen induced atopic dermatitis in NC/Nga mice Kyouko Yamawaki, Y. Watanabe, K. Asano, S. Aoki, K. Terasita, E. Takahashi, M. Toutani, S. Mizobuchi; Nankoku, Japan P5.16 LIVER IMMUNOLOGY Session Time: Tuesday, August 27, 13:20 - 15:00 333 P5.16.01 - Contribution of quanta-lite® M2 EP (MIT3) test in primary biliary cirrhosis immunological diagnosis Mounira Benidir, S.S. Salah, A. Aït-Kaci, S. Kebbab, S. Semmane, M.C. Abbadi; Algiers, Algeria 334 P5.16.02 - Interleukin-6 and C-reactive protein are overexpressed in the liver of perinatal deaths diagnosed with fetal inflammatory response syndrome L.H.M. Pereira, J.R. Machado, J.G.P. Olegário, L.P. Rocha, M.V. Silva, C.S.O. Guimarães, M.A. Reis, Lucio R. Castellano, F.S. Ramalho, R.R.M. Corrêa; João Pessoa Paraíba, Brazil 335 P5.16.03 - Critical role of invariant natural killer T cells in xenobiotic induced murine model of primary biliary cirrhosis C. Chang, H. Jen, Y. Chen, Ya-Hui Chuang; Taipei, Taiwan 336 P5.16.04 - Deranged neutrophil phagocytic capacity on cirrhosis and hyperammonemia is recovered by the blue agave inulin effect on cirrhotic patient gut microbiota A.J. Tovar-Cuevas, J.E. Segura-Ortega, G.E. Hernandez-González, J. Ríos-Bojorquez, V. Delgado-Rizo, Mary Fafutis-Morris; Guadalajara, Mexico 337 P5.16.05 - Disruption of chemokine-glycosaminoglycan interactions protects the liver in the murine Concanavalin A-induced acute hepatits model Rafael Fernandez-Botran, Q. Xie, L. Gobejishvili, Z. Zhang, S. Joshi-Barve, C. McClain, S. Barve; Louisville, United States 338 P5.16.06 - Development of a new murine model for autoimmune hepatitis useful for pathogenic studies and preclinical trials Irene Gil Fariña, M. di Scala, N. Zabaleta, E. López-Franco, C. Olagüe, Á. Vales, L. Guembe, J. Prieto, G. González-Aseguinolaza; Pamplona, Spain 339 P5.16.07 - High frequency of antiphospholipid antibodies in primary biliary cirrhosis A. Mankai, W. Manoubi, W. Sakly, A. Achour, Y. Thabet, Ibtissem Ghedira; Tunis, Tunisia 340 P5.16.08 - CD8 T cell responses to T cell apoptosis-derived antigens as a marker of chronic immune activation and liver inflammation in chronic HCV infection Helene Martini, A. Citro, S. Piconese, G. Labbadia, G. D’Ettorre, V. Vullo, V. Barnaba; Rome, Italy 248 Posters - August 27 341 P5.16.09 - Activation of CD11b+ Kupffer cells/macrophages as a common cause for exacerbation of TNF/ Fas-ligand-dependent hepatitis in hypercholesterolemic mice Hiroyuki Nakashima, Y. Ogawa, S. Shono, M. Kinoshita, M. Nakashima, A. Sato, M. Ikarashi, S. Seki; Saitama, Japan 342 P5.16.10 - In vitro infection with Hepatitis C Virus increases the phenotype and the suppressive activity of the human regulatory T cell Laurissa Ouaguia, O. Morales, M. Senechal, C. Wychowski, A. Carpentier, L. Aoudjehane, Y. Calmus, Y. de Launoit, F. Conti, N. Delhem; Lille, France 343 P5.16.11 - Disproportionate decline of liver infiltrating regulatory T cells under therapy for autoimmune hepatitis Richard Taubert, M. Hardtke-Wolenski, F. Noyan, A. Wilms, A. Baumann, J. Schlue, S. Olek, M. Manns, E. Jaeckel; Hannover, Germany 344 P5.16.12 - IFNγ/STAT1-mediated tissue factor expression contributes to T cell-mediated hepatitis via induction of hypercoagulation in mice Hiroko Tsutsui, R. Uchiyama; Nishinomiya, Japan P5.21 MYELO- AND LYMPHO-PROLIFERATIVE DISORDERS Session Time: Tuesday, August 27, 13:20 - 15:00 345 P5.21.01 - Myeloid cell-derived reactive oxygen species trigger ERK pathway-dependent parthanatos in human lymphocytes Ali A. Akhiani, J. Aurelius, O. Werlenius, C. Movitz, A. Martner, K. Hellstrand, F.B. Thorén; Göteborg, Sweden 346 P5.21.02 - Notch signalling controls leukemic cells Mariastefania Antica, M. Paradžik, M. Kunšti , M. Konjevi , M. Matuli ; Zagreb, Croatia 347 P5.21.03 - Vasculitis associated myelodysplasia in a prospective 4 year study Cristina Belizna, A. Ghali, D. Henrion, J. Voswinkel, N. Ifrah; Angers, France 348 P5.21.04 - CD137 ligand reverse signalling induces differentiation of primary acute myeloid leukaemia cells Kin Cheng, S. Wong, Y. Linn, L. Ho, H. Schwarz; Singapore, Singapore 349 P5.21.05 - Serum free ligh