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Transcript 
Characterization of an Extensive Transverse Tubular
Network in Sheep Atrial Myocytes and its Depletion in
Heart FailureCLINICAL PERSPECTIVE
by Katharine M. Dibb, Jessica D. Clarke, Margaux A. Horn, Mark A. Richards, Helen
K. Graham, David A. Eisner, and Andrew W. Trafford
Circ Heart Fail
Volume 2(5):482-489
September 1, 2009
Copyright © American Heart Association, Inc. All rights reserved.
Figure 1. Specimen deconvolved images of cell membranes of sheep atrial myocytes.
Katharine M. Dibb et al. Circ Heart Fail. 2009;2:482-489
Copyright © American Heart Association, Inc. All rights reserved.
Figure 2. Measurement of proximity of t-tubules and surface membrane to voxels within a sheep
atrial myocyte.
Katharine M. Dibb et al. Circ Heart Fail. 2009;2:482-489
Copyright © American Heart Association, Inc. All rights reserved.
Figure 3. Comparative measurements on sheep ventricular and rat atrial myocytes.
Katharine M. Dibb et al. Circ Heart Fail. 2009;2:482-489
Copyright © American Heart Association, Inc. All rights reserved.
Figure 4. Half-distance of voxels in the cell from the nearest membrane.
Katharine M. Dibb et al. Circ Heart Fail. 2009;2:482-489
Copyright © American Heart Association, Inc. All rights reserved.
Figure 5. Correlation between t-tubules and intracellular release of Ca2+.
Katharine M. Dibb et al. Circ Heart Fail. 2009;2:482-489
Copyright © American Heart Association, Inc. All rights reserved.
Figure 6. Loss of atrial t-tubules in heart failure (HF).
Katharine M. Dibb et al. Circ Heart Fail. 2009;2:482-489
Copyright © American Heart Association, Inc. All rights reserved.
Figure 7. Spatial features of the Ca2+ transient in a myocyte from a heart failure sheep.
Katharine M. Dibb et al. Circ Heart Fail. 2009;2:482-489
Copyright © American Heart Association, Inc. All rights reserved.
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