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Thursday May 9, 2013 LIFE-CHANGING RESEARCH MAY 5 – 9 | SEATTLE 342 530 Gene Therapy and Delivery [PH] #5963-5969 532 Corneal Wound Repair and Healing [CO] #5974-5980 533 Disruptions to Visual Development: Detection, Treatment and Consequences [EY] #5981-5987 531 Beyond Large Print: Advances in Accessibility and Technology for the Visually Impaired — Minisymposium [LV] #5970-5973 TCC 303 TCC 305 TCC LL 4/5 528 Photoreceptor Degeneration and Death [RC] #5949-5955 611-614 618-620 527 Cataract II [LE] #5942-5948 609 529 Refractive Error and Visual Function: What Affects How We See [CL] #5956-5962 526 Anatomy Challenges for the Future [AP] #5935-5941 608 615-617 525 Clinical and Translational Studies in Ocular Inflammation [IM] #5928-5934 524 Imaging: Diagnostic and Function [RE] #5921-5927 502 ER Stress and the Unfolded Protein Response in Ocular Health and Disease [BI, RE, RC, PH, LE, GL, CO] #5362-5367 6C 606-607 523 Structure/Function [GL] #5914-5920 501 Restoration of Vision [BI, VI, RE, RC, PH, NT, LE, GL, GEN, CO, CL] #5355-5361 8:30–10:30am Symposium 10:30am–12:15pm 6B Room Thursday, May 9 548 ARVO/Alcon Keynote Series 2–3:15pm Orlando Welcomes ARVO 2014 Kickoff Reception East Lobby, 6th Floor 3:15–4pm Networking Happy Hour, Exhibit Halls, 12:30–2pm Exhibit Halls, 10am–2pm 343 Posterior Segment Inflammation II [IM, BI] Anterior Eye: Physiology and Pharmacology [PH, AP] Ocular Surface in Health and Disease [CO] Contact Lens II [CO, VI] Image Processing and Segmentation Algorithms [MOI] Improving Imaging and Ophthalmic Instrumentation [VI] Diabetic Retinopathy and Vascular Biology II [RC] Glia in Health and Disease [RC] Intraocular Pressure [GL] Pediatric Epidemiology [CL] Myopia, CL [CL] Vision Impairment [CL] Chemical Composition and Physical Properties [LE] Trauma [RE] Laser/Intravitreal Treatment [RE] Vitreoretinal Surgery III [RE] Retina-RPE Transplantation [RE] Imaging II, RE [RE] Ocular and Orbital Tumors [AP] Thyroid Eye Disease [EY] 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 Session Title 8:30–10:15am 503 Session Number Thursday, May 10 n Posters #5900-5913 #5874-5899 #5819-5873 #5811-5818 #5764-5810 #5760-5763 #5754-5759 #5730-5753 #5719-5729 #5693-5718 #5664-5692 #5615-5663 #5582-5614 #5555-5580 #5543-5554 #5491-5542 #5453-5490 #5418-5452 #5399-5417 #5368-5398 (D0263-D0276) (D0237-D0262) (D0130-D0184) (D0071-D0078) (D0011-D0057) (D0007-D0010) (D0001-D0006) (C0201-C0224) (C0190-C0200) (C0164-C0189) (C0135-C0163) (C0001-C0049) (B0105-B0137) (B0078-B0103) (B0053-B0064) (B0001-B0052) (A0152-A0189) (A0117-A0151) (A0043-A0061) (A0001-A0031) ProgramBoard Number Number Dry Eye and Lacrimal Gland V [CO, VI] Inner Retina and Blood Vessels [VI] Cell Biology of the Retina and RPE II [RC, VN] Apoptosis and Cell Stress [BI] Advancing Functional Assessment of the Visual System [VN, VI] Bipolar and Horizontal Cells [VN] Genetic Risk Factors for Common Eye Disorders with Complex Inheritance [GEN, VN] Genetics II [GL] Proliferative Vitreoretinopathy [RE] AMD IV, RE [RE] Retina: Physiology and Pharmacology [PH, BI, VN] Oculoplastics: Eyelids [EY] 536 537 538 539 540 541 542 543 544 545 546 #6366-6382 #6314-6365 #6263-6313 #6250-6262 #6216-6249 #6165-6215 #6145-6164 #6119-6144 #6109-6118 #6067-6108 #6054-6066 #5999-6053 #5988-5998 (D0277-D0293) (D0185-D0236) (D0079-D0129) (D0058-D0070) (C0101-C0134) (C0050-C0100) (B0216-B0235) (B0190-B0215) (B0180-B0189) (B0138-B0179) (B0065-B0077) (A0062-A0116) (A0032-A0042) ProgramBoard Number Number 12:30–1:30pm: All Posters — authors will be present at poster boards 12:30–2pm: Networking Happy Hour in Exhibit/Poster Halls. Poster board numbers indicate location: Poster Area A and B = South Exhibit Hall; Poster Area C and D = North Exhibit Hall Corneal Infection/Inflammation II [IM, CO] 535 Session Title 534 Session Number 10:30am–12:15pm NOTES NOTES _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ 344 266 Thursday – Symposium – 5355 – 5367 6B 6C Thursday, May 09, 2013 8:30 AM-10:30 AM Thursday, May 09, 2013 8:30 AM-10:30 AM Biochemistry/Molecular Biology / Clinical/ Epidemiologic Research / Cornea / Genetics / Glaucoma / Lens / Nanotechnology and Regenerative Medicine / Physiology/ Pharmacology / Retinal Cell Biology / Retina / Visual Psychophysics / Physiological Optics Biochemistry/Molecular Biology / Cornea / Glaucoma / Lens / Physiology/Pharmacology / Retinal Cell Biology / Retina 501 Restoration of Vision The greatest contributions to life-changing research may be the ability to restore vision. A number of advancements in ophthalmic research have already achieved this with corneal transplants, retinal prosthetics, and gene therapy. In addition, rapidly developing therapies using stem cells and optogenetics are poised to offer new therapeutic options for eye disease. An important element of this work is the higher order processing that must occur to incorporate the newly restored visual input from the retina. This symposium provides an overview of each of these areas by a dynamic leader in the field. Each speaker will examine the recent developments in their area and the exciting advancements that will continue to provide new opportunities for sight to individuals with blinding eye disease. Moderators: Machelle Pardue and David Berson 5355 — 8:30 Corneal Transplants. Donald T. Tan. Singapore National Eye Center, Singapore, Singapore *CR 5356 — 8:46 Stem Cell Transplantation. Kang Zhang. Attn: Zhang Lab-Osler Ln, Univ Of California, San Diego, La Jolla, CA *CR 5357 — 9:02 Stem Cell Therapy. Thomas A. Reh. Dept of Biological Structure, University of Washington, Seattle, WA 5358 — 9:18 Retinal Prosthetics. Eberhart Zrenner. Institute for Ophthalmic Research, Centre for Ophthalmology, Tuebingen, Germany *CR 5360 — 9:50 Optogenetics. Botond Roska. Friedrich Mieshcer Institute for Biomedical Research, Basel, Switzerland *CR 5361 — 10:06 Learning to See Late in Life. Pawan Sinha. Brain and Cognitive Sciences, MIT, Cambridge, MA Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) have been implicated in a variety of biological and pathological processes, the latter including atherosclerosis, Alzheimer’s disease, Parkinson’s disease, and diabetes, to name but a few. In the eye, ER stress and the UPR have been associated with several clinically significant diseases, including glaucoma, age-related macular degeneration, corneal dystrophy, and cataracts. In addition, ER stress also is a normal process that occurs during ocular development, such as in the formation of the lens. This symposium will present a succinct overview of the key features of ER stress and UPR mechanisms, as well as the evidence pointing to their involvement in ocular diseases and the development of novel therapeutic approaches to intervene in or prevent such diseases. Moderators: Steven J. Fliesler and Melinda K. Duncan — 8:30 Introduction 5362 — 8:35 Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response. Randal J. Kaufman. Neuroscience & Stem Cell Research, SanfordBurnham Medical Research Institute, La Jolla, CA 5363 — 8:55 ER Stress and the Unfolded Protein Response in Diabetic Retinopathy. Sarah X. Zhang. Ophthalmology, SUNY-Buffalo, Buffalo, NY 5364 — 9:14 Targeting ER Stress and the Unfolded Protein Response in Treatment of Primary Open Angle Glaucoma. Gulab S. Zode. Univ of Iowa, Howard Hughes Medical Institute, Iowa City, IA *CR 5365 — 9:33 The Unfolded Protein Response in the Control of Normal Lens Development and Cataract. Melinda K. Duncan. Biological Sciences, University of Delaware, Newark, DE 5366 — 9:52 7-Ketocholesterol-mediated ER Stress is an Age-Related Risk Factor in the Pathogenesis of AMD. Ignacio R. Rodriguez. LRCMB-MRDS, National Eye Institute, Bethesda, MD 5367 — 10:11 Fuchs Endothelial Corneal Dystrophy: Role of the Unfolded Protein Response in Cellular Pathogenesis. Albert S. Jun. Ophthal-Smith 5011, Johns Hopkins Wilmer Eye Inst, Baltimore, MD *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 345 Thursday Symposium 8:30 am – 10:30 am 5359 — 9:34 Range of retinal targets amenable to AAV mediated gene therapy. William W. Hauswirth. Dept. of Ophthalmology, University of Florida College of Medicine, Gainesville, FL *CR 502 ER Stress and the Unfolded Protein Response in Ocular Health and Disease 5368 – 5386 – Thursday – Posters Exhibit Hall A0001-A0031 Thursday, May 09, 2013 8:30 AM-10:15 AM Immunology/Microbiology / Biochemistry/ Molecular Biology 503 Posterior Segment Inflammation II Moderator: Manfred Zierhut 5368 — A0001 Pivotal roles of EBI3 for the initiation and maintenance of experimental autoimmune uveitis. Atsunobu Takeda1, T. Yoshimura1, E. Hasegawa1, S. Hirakawa1, T. Hisatomi1, K. Sonoda2, T. Ishibashi1. 1 Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; 2 Ophthalmology, Graduate School of Medicine, Yamaguchi University, Ube, Japan 5369 — A0002 The effect of light on retinal structure and the development of EAU in the transgenic spontaneous model of uveitis. Clare L. Corbett, E. Muckersie, J. V. Forrester. Ophthalmology, University of Aberdeen, Aberdeen, United Kingdom 5370 — A0003 Comparison of Pharmacokinetic profiles of Sirolimus following Subconjunctival or Intravitreal Administrations in Rabbits and Humans. Masaaki Kageyama1, J. Naor2, H. Takanaga1, L. J. Wilson2, N. Ihekoromadu2, A. A. Khwaja2, S. Mudumba1. 1Research & Development, Santen Inc, Emeryville, CA; 2Global Clinical Development & Medical Affairs, Santen Inc, Emeryville, CA *CR, f 5371 — A0004 Regulatory Effect of Interleukin 37 in Behcet’s disease. Zi Ye1, C. Wang1, A. Kijlstra2, P. Yang1. 1The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing, China; 2University Eye Clinic Maastricht, Maastricht, Netherlands Thursday Posters 8:30 am – 10:15 am 5372 — A0005 Efficacy of Rebamipide in an Endotoxin-Induced Uveitis Model. Akira Takamiya, H. Yokota, A. Shimouchi, A. Yoshida. Ophthalmology, Asahikawa Medical Unversity, Asahiawa, Japan *CR 5373 — A0006 Evidence-Based Analysis for the Medical Treatment of Behçet’s Disease. Philip I. Murray, M. Mubin, H. Knott, B. Markandey, N. Joji, R. Malhotra, A. K. Denniston. Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom 5374 — A0007 Activation of the aryl hydrocarbon receptor(AhR) inhibits Th1 and Th17 cell immune response in Behcet’s disease. Peizeng Yang1, C. Wang1, Z. Ye1, A. Kijlstra2. 1 Ophthal, The 1st Hosp, Chongqing Medical University, Chongqing, China; 2University Eye Clinic Maastricht, Maastricht, Netherlands 5375 — A0008 Comparison of the Spectral Domain Optical Coherence Tomography Characteristics in Patients with Multifocal Choroiditis and Punctate Inner Choroidopathy. Roomasa Channa1, J. Wang2, M. A. Ibrahim1, J. Lee1, D. Ferraz1, Y. J. Sepah1, M. G. Bittencourt1, R. Sophie1, E. Hatef Naimi1, Q. Nguyen1. 1Retinal Imaging Research and Reading Center, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD; 2Dana Center, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD *CR 5382 — A0015 Choroidal Bulging in Patients with Vogt-Koyanagi-Harada and Long-standing Disease. Viviane M. Sakata1, F. G. da Silva1, C. Hirata1, E. Olivalves1, W. Y. Takahashi1, R. A. Costa2, 3, J. H. Yamamoto1. 1Ophthalmology, Hospital das Clínicas da Faculdade de Medicina da Universidade São Paulo, São Paulo, Brazil; 2 Division of Macula: Imaging & Treatment, Centro Brasileiro de Ciências Visuais, Belo Horizonte, Brazil; 3Ophthalmology, Faculdade de Medicina da Universidade de Ribeirão Preto, Ribeirão Preto, Brazil *CR 5376 — A0009 Fundus autofluorescence and birdshot chorioretinopathy: a study of 162 patients. Astrid Queant, D. Monnet, A. P. Brezin. Cochin Hospital, Paris, France 5383 — A0016 Sympathetic ophathalmia: Histopathological and Immunohistochemical Characteristics. Hassan Aziz, H. W. Flynn, R. C. Young, J. L. Davis, S. R. Dubovy. Bascom Palmer Eye Institute, Miami, FL 5377 — A0010 Treatment Paradigms in Retinal Vasculitis. Jacqueline R. Busingye1, S. Schwartzman2, 3, J. M. Ackert1, T. Flynn1. 1 Ophthalmology, Mount Sinai School of Medicine, New York, NY; 2Rheumatology, Hospital for Special Surgery, New York, NY; 3Rheumatology, Weill Medical College of Cornell University, New York, NY *CR 5378 — A0011 Punctate Inner Choroidopathy characterization by Enhanced Depth ImagingOptical Coherence Tomography: Quantitative analysis of Retinal and Choroidal layers by manual segmentation. Noa Fernandez Ledo, J. Zarranz-Ventura, D. A. Sim, P. A. Keane, C. A. Egan, P. J. Patel, M. C. Westcott, R. W. Lee, A. Tufail, C. E. Pavesio. Medical Retina, Moorfields Eye Hospital, London, United Kingdom *CR 5379 — A0012 Clinical course of a cohort of patients with Punctate Inner Choroidopathy managed with different modalities of treatment in North Scotland. Shiao Wei Wong1, 2, P. Tyagi2, K. Khan1, S. Hewick2, L. Kuffova1. 1Aberdeen Royal Infirmary, NHS, Aberdeen, United Kingdom; 2 Raigmore Hospital, NHS, Inverness, United Kingdom 5380 — A0013 Clinical Characteristics of Vogt-Koyanagi-Harada Disease with Choroidal Folds. Kouhei Hashizume1, Y. Imamura2, T. Fujiwara1, S. Machida1, M. Ishida2, D. Kurosaka1. 1 Ophthalmology, Iwate Medical University, Morioka, Japan; 2Ophthalmology, Teikyo University School of Medicine, Mizonokuchi Hospital, Kawasaki, Japan 5381 — A0014 Clinical Outcomes of VogtKoyanagi-Harada Disease at a Tertiary Center in 194 Patients: The KKESH Uveitis Survey Study Group. Abdulaziz A. Alrushood1, 4, J. Arevalo1, 2, H. A. Al Dhibi1, Y. A. Al-Zahrani1, V. Gupta1, S. M. Alsulaiman1, A. F. Lasave3, H. N. Al-Shamsi1. 1 Retina and Vitreous, KKESH, Riyadh, Saudi Arabia; 2Retina and Vitreous, Wilmer Eye Institute, Baltimore, MD; 3Retina and Vitreous, Clínica de Oftalmologia de Cali and Hospital Universitario del Valle, cali, Cambodia; 4Ophthalmology, Dammam universty, dammam, Saudi Arabia *CR 5384 — A0017 Natural history of Multiple Evanescent White Dot Syndrome: a multimodality imaging study. Mafalda Macedo1, 2, S. Vaz-Pereira1, 3, G. De Salvo1, B. Pal1. 1Medical Retina Department, Moorfields Eye Hospital, London, United Kingdom; 2Department of Ophthalmology, Hospital de Santo Antonio-CHP, Porto, Portugal; 3Department of Ophthalmology, Hospital de Santa Maria, Lisbon, Portugal 5385 — A0018 A retrospective analysis of the natural history and management of serpiginous choroidopathy (SC) in Australia and New Zealand. Anthony J. Hall1, 2, J. Toniolo1, 2, J. Sims4, S. Fraser-Bell5, J. Khan6, C. Younan7, B. Kent-Smith8, S. Young9, E. Paul2, L. Lim3. 1 Ophthalmology, Alfred Hospital, Melbourne, Prahran, VIC, Australia; 2Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, VIC, Australia; 3Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC, Australia; 4Auckland Eye, Auckland, New Zealand; 5Sydney Eye Hospital, Sydney, NSW, Australia; 6Ophthalmology, Royal Perth Hospital, Perth, WA, Australia; 7 Ophthalmology, Westmead Hospital, Sydney, NSW, Australia; 8Ophthalmology, Whangarei Area Hospital, Whangarei, New Zealand; 9 Ophthalmology, Repatriation General Hospital, Sydney, NSW, Australia 5386 — A0019 MicroRNA-146a and Ets1 gene polymorphisms in ocular Behcet’s disease and Vogt-Koyanagi-Harada syndrome. Qingyun Zhou1, A. Kijlstra2. 1Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; 2Eye Research Institute Maastricht, Maastricht, Netherlands The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 346 Thursday – Posters – 5387 – 5408 5387 — A0020 Characteristics, Complications, and Surgical Outcomes of Panuveitis in 400 patients (727 eyes) over 25 Years: The KKESH Uveitis Survey Study Group. J Fernando Arevalo1, 2, A. F. Lasave3, H. N. Al-Shamsi2, S. M. Al Sulaiman2, A. A. Alrushood2, Y. A. Alzahrani2, V. Gupta2, A. M. Al-Mahmood4, H. A. Al Dhibi2. 1 Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD; 2Vitreoretinal Division, King Khaled Eye Specialist Hosp, Riyadh, Saudi Arabia; 3Clínica de Oftalmologia de Cali and Hospital Universitario del Valle, Cali, Colombia; 4Anterior Segment and Uveitis Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia *CR 5388 — A0021 Comparison of the effect of Dexamethasone drug delivery system in macular edema in patients with uveitis or retinal vein occlusion. Thomas Ness, D. Boehringer, A. Pielen, S. Heinzelmann. University Eye Hospital, University of Freiburg, Freiburg, Germany *CR 5389 — A0022 Involvement of Vitreous in Castleman’s Disease. Sunju Park, M. S. Katz, D. C. Gritz. Ophthalmology and VIsual Sciences, AECOM/Montefiore Medical Center, Bronx, NY 5390 — A0023 The use of Bromfenac for the Treatment of Macular Edema Secondary to NonInfectious Uveitis. Joanna Saade, M. Abdulaal, R. N. Hamam. American University of Beiirut, Beirut, Lebanon 5391 — A0024 Assessment of Changes in Quality of Life Among Patients in the SAVE Study - Sirolimus As Therapeutic Approach To UVEItis: A Randomized Study To Assess The Safety And Bioactivity Of Intravitreal And Subconjunctival Injections Of Sirolimus In Patients With Non-infectious Uveitis. Erin Vigil, Y. J. Sepah, O. O. Agbedia, A. L. Watters, M. A. Sadiq, M. Ansari, M. G. Bittencourt, M. A. Ibrahim, Q. Nguyen. The Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD *CR, f 5392 — A0025 Mycophenolate Mofetil in Refractory Non-infectious Uveitis. Manoel Gusmao Isidro, V. M. Sakata, D. C. Cavalcanti, J. Zaghetto, E. Olivalves, C. Hirata, J. H. Yamamoto. Hospital das Clinicas da Faculdade de Medicina da Universidade São Paulo, São Paulo, Brazil 5394 — A0027 Decline in Ocular Toxoplasmosis in the Midwestern United States. Asim Farooq1, J. H. Hou1, S. Patel1, 2, H. Tessler1, D. A. Goldstein1, 3. 1 Ophthalmology, Illinois Eye & Ear Infirmary, Chicago, IL; 2Ophthalmology, Weill Cornell Medical College, New York, NY; 3Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL *CR 5396 — A0029 The serum angiotensin converting enzyme and lysozyme levels in patients with ocular involvement of ankylosing spondylitis, behcet disease, sarcoidosis and latent tuberculosis. Ozlem Gurses1, E. Karaismailoglu1, 2. 1 Ophthalmology, Middle East Technical University, Oran ankara, Turkey; 2Statistics, Hacettepe University Medical Faculty, Ankara, Turkey f 5397 — A0030 Inflammatory activity and visual outcomes in patients treated with cryotherapy for pars planitis. Benjamin C. Chaon, J. C. Folk, E. H. Sohn. Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA 5398 — A0031 Predictive factors for postoperative complications in diagnostic vitrectomy. Michael Karampelas1, R. Moya1, D. A. Sim1, 2, J. Zarranz-Ventura1, D. G. Charteris1, R. W. Lee1, 3, C. E. Pavesio1, 2. 1NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom; 2University College London, Institute of Ophthalmology, London, United Kingdom; 3 Department of Clinical Sciences, University of Bristol, Bristol, United Kingdom *CR Exhibit Hall A0043-A0061 Thursday, May 09, 2013 8:30 AM-10:15 AM Physiology/Pharmacology / Anatomy/Pathology 504 Anterior Eye: Physiology and Pharmacology 5401 — A0045 The effect of sulindac liposome on inflammation induced corneal neovascularization. Jun-Sub Choi, C. Joo. Ophthalmology & Visual Science, Catholic Univ Korea Coll of Med, Seoul, Republic of Korea 5402 — A0046 Application of phosphoproteomic analysis in myopic chick retina. Fengjuan Yu1, K. Li1, T. Lam1, C. To1, 2. 1 Laboratory of Experimental Optometry, School of Optometry, the HongKong Polytechnic University, Kowloon, Hong Kong; 2State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, SunYat-sen University, Guangzhou, China 5403 — A0047 Gender, Ethnicity, and Time After Awakening Affect Tear Film Cytokine Concentrations. Meng C. Lin1, 2, J. O. Niimi1, N. A. McNamara2, 3, Y. Zhou1, J. Shumaker1, H. M. French1, T. Leung1, S. L. Wang1, K. Siemasko4, M. E. Stern4. 1School of Optometry, Clinical Research Center, University of California, Berkeley, Berkeley, CA; 2School of Optometry, University of California, Berkeley, Berkeley, CA; 3Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, CA; 4Allergan, Inc, Irvine, CA *CR 5404 — A0048 Cross-Species and Cross-Age Comparison of Esterase Mediated Metabolism in Vitreous Humor: Human versus Rabbit, Dog and Monkey. Mayssa Attar, J. Shen, M. S. Kim, Q. Radojicic. Drug Safety Evaluation, Allergan, Irvine, CA *CR 5405 — A0049 Bicarbonate sensitive soluble adenylyl cyclase (sAC) generates the cAMP in aqueous humor (AH). Yong Lee1, Y. Lee1, L. Ramos-Espiritu3, L. Y. Marmorstein1, J. Buck3, L. Levin3, A. D. Marmorstein1, 2. 1Ophthalmology and Vision Science, University of Arizona, Tucson, AZ; 2 Physiology, University of Arizona, Tucson, AZ; 3 Pharmacology, Weill Cornell College of Medicine, New York, NY *CR Moderator: Caterina Gagliano 5406 — A0050 Beneficial Assessment of A Combined Tropicamide and Various Oxime Treatments Against Miosis and Visual Dysfunction Following Ocular Exposure to the Nerve Agent Sarin. 5399 — A0043 Induction of MAPK Phosphatase-1 by the Novel Selective Glucocorticoid Receptor Agonist Mapracorat Suppresses Inflammatory Signaling Pathways in Human Corneal Epithelial Cells. Megan E. Cavet, K. L. Harrington, T. R. Vollmer, M. Richardson, J. Zhang. Pharmaceutical R&D, Bausch & Lomb, Rochester, NY *CR 5407 — A0051 Dexamethasone Modifies Viability of Mitomycin C-Treated Tenon’s Fibroblasts. Shu-Wen Chang1, 2, W. Ho1, T. Chen1, S. Chou3. 1Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan; 2 Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; 3Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City, Taiwan 5400 — A0044 Pirfenidone nanoparticles improve healing and prevent corneal scarring following alkali burn. Sarbani Hazra1, S. Chowdhury2, R. Guha2, T. Ruchit3, U. B. Kompella3, A. Konar2. 1Veterinary Surgery & Radiology, WBUAFS, Kolkata, India; 2Animal Facilities, Indian Institute of Chemical Biology, Kolkata, India; 3Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO *CR 5408 — A0052 TRPV1 and corneal Pain. Eric Senning, S. E. Gordon. Physiology and Biophysics, University of Washington, Seattle, WA f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 347 Thursday Posters 8:30 am – 10:15 am 5393 — A0026 Study of the Prevalence of Ophthalmology Uveitis Tertiary Hospital in Teresina-Pi. Leonardo Pinheiro Teixeira1, L. Rosa Ribeiro Cunha1, C. Dar’k Amorim Teles1, V. Cortizo2. 1Faculdade de Saúde Ciencias Humanas e Tecnológicas do Piauí - NOVAFAPI, Teresina- PI, Brazil; 2Universidade Federal do Piauí - UFPI, Teresina- PI, Brazil 5395 — A0028 Treatments and visual outcomes in patients with ocular sarcoidosis. Hisae Nakahara1, 2, T. Kaburaki1, M. Takamoto1, A. Yoshida3, K. Okinaga1, J. Numaga1, K. Ando1, Y. Fujino1, 4, H. Kawashima3, S. Amano1. 1 Ophthalmology, Univ of Tokyo School of Med, Bunkyo-ku, Japan; 2Ophthalmology, Senpo Tokyo Takanawa Hospital, Minato-ku, Japan; 3 Ophthalmology, Jichi Medical University, Shimotsuke-shi, Japan; 4Ophthalmology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Japan *CR 5409 – 5430 – Thursday – Posters 5409 — A0053 Different Roles of Carbonic Anhydrase in Human vs. Bovine Corneal Endothelial Transport. Thomas M. Malikowski1, M. E. Duffey2, S. P. Patel3, 4. 1School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, NY; 2Physiology & Biophysics, University at Buffalo, Buffalo, NY; 3Ophthalmology, SUNY Eye Institute, University at Buffalo, Buffalo, NY; 4 Research Service, VAWNYHS, Buffalo, NY *CR 5410 — A0054 ROCK Inhibitor Y-27632 Enhances the Mucin Secretion from Goblet Cells Derived from Limbal Stem Cells. Won Seok Choi1, E. Chung2, T. Chung2, J. Hyon3, 4, W. Wee3, Y. Shin1. 1Ophthalmology, Hallym University College of Medicine, Seoul, Republic of Korea; 2 Ophthalmology, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; 3 Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea; 4 Ophthalmology, Seoul National University Bundang Hospital, Seoul, Republic of Korea 5411 — A0055 Impact of Acute Exposure to High Altitude on Anterior Chamber Geometry. M Dominik Fischer1, 2, G. Willmann1, A. Schatz1, K. Schommer3, A. Zhour1, E. Zrenner1, K. BartzSchmidt1, F. Gekeler1. 1Centre for Ophthalmology, University Hospital Tuebingen, Tuebingen, Germany; 2Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom; 3 Department of Sports Medicine, Medical Clinic, University Hospital Heidelberg, Heildelberg, Germany *CR 5412 — A0056 Evaluation of Feature Detectors and Descriptors on the Iris. Sandro I. De Zanet1, 2, M. Rueegsegger1, 2, T. Rudolph1, 2, S. Wolf2, J. H. Kowal1, 2. 1Ophthalmic Technologies ARTORG Center, University of Bern, Bern, Switzerland; 2 Department of Ophthalmology, University of Bern, Bern, Switzerland *CR Thursday Posters 8:30 am – 10:15 am 5413 — A0057 Tear Film and Lid Margins in Over-Blink. Heiko Pult2, 1, B. H. Riede-Pult2, 1, C. A. Blackie3, 4, P. J. Murphy5, D. R. Korb3, 4. 1 School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom; 2Dr. Heiko Pult - Optometry and Vision Research, Weinheim, Germany; 3TearScience Inc., MA, USA, Boston, MA; 4Korb Associates, Boston, MA; 5School of Optometry and Vision Sciences, University of Waterloo, Waterloo, ON, Canada *CR 5414 — A0058 The role of reactive oxygen species on cytotoxicity of moxifloxacin and benzalkonium chloride on human corneal epithelial cells. Ta-Ching Chen, F. Hu. National Taiwan University Hospital, Taipei, Taiwan 5415 — A0059 Growth factor secretion in human keratocyte cultures following photodynamic inactivation (PDI). Tanja Stachon1, J. Wang1, 2, A. Langenbucher3, B. Seitz1, N. Szentmáry1. 1Department of Ophthalmology, Saarland University Hospital, Homburg/Saar, Germany; 2Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, China; 3 Experimental Ophthalmology, Saarland University, Homburg/Saar, Germany 5416 — A0060 Efficacy of a novel synthetic topical tetrapeptide on eliciting analgesia subsequent to experimentally induced chemical corneal injury. Bruce I. Gaynes, M. Russo, D. Goldmeier. Ophthalmology, Loyola University Chicago, Maywood, IL *CR 5417 — A0061 Enantiomeric Separation, Ophthalmic Formulations and Mydriatic Activity Oo Cyclopentolate Hydrochloride. Danilo Aleo1, S. Mangiafico1, M. G. Saita1, B. Melilli1, M. G. Cro1, S. Mangiafico1, N. D’Antona2, G. Nicolosi2. 1R&D, Medivis, Catania, Italy; 2 Istituto Chimico Biomolecolare, CNR, Catania, Italy *CR Exhibit Hall A0117-A0151 Thursday, May 09, 2013 8:30 AM-10:15 AM Cornea 505 Ocular Surface in Health and Disease Moderator: Mary Ann Stepp 5418 — A0117 A Modified Delphi Technique to Obtain Consensus on the Scoring of Ocular Surface Disease Damage and Activity Indices. Priscilla Mathewson, G. P. Williams, P. J. Tomlins, S. Kolli, P. I. Murray, S. Rauz. Academic Unit of Ophthalmology, University of Birmingham, West Midlands, United Kingdom 5419 — A0118 Indications and Outcomes of the Needle Dissection Technique for the Full Gundersen Conjunctival Flap in 76 eyes. Heidrun Gollogly, L. Maguire. Ophthalmology, Mayo Clinic, Rochester, MN 5420 — A0119 Characterization of patients with ocular chronic graft-versus-host disease and evaluation of a new grading scale. Christiane Blecha1, D. Wolff2, D. A. Maerker1, H. Helbig1, T. Dietrich-Ntoukas1. 1Ophthalmology, University Hospital Regensburg, Regensburg, Germany; 2 Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany 5421 — A0120 Proliferative Gain of Function of Stromal Fibroblasts via SDF-1 in Pathogenesis of Pterygia. Kyoung Woo Kim, S. Park, J. Kim. Department of Ophthalmology, Chung-Ang University Hospital, Seoul, Republic of Korea 5422 — A0121 Behaviour of Conjunctival Goblet Cells after allogenic Hematopoietic Stem Cell Transplantation. Alexandra B. Knoll1, E. Jakob1, K. Brandauer1, B. C. Dobner1, U. Hegenbart3, P. Dreger3, G. Auffarth2, F. Mackensen1. 1 Interdisciplinary Uveitis Center, University Hospital Heidelberg, Heidelberg, Germany; 2 Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany; 3Heamatology, University Hospital Heidelberg, Heidelberg, Germany *CR 5423 — A0122 Differences among signs and symptoms of dry eye among patients with Sjogren’s syndrome, blepharitis, or no ocular surface disease. Bridgette E. McCabe1, M. Massaro-Giordano1, N. M. Fuerst1, M. Pistilli1, G. Ying1, I. Macchi2, 1, R. Salvo1, V. Y. Bunya1. 1 Scheie Eye Institute- Ophthalmology, University of Pennsylvania, Philadelphia, PA; 2Campus Biomedico Rome, Rome, Italy *CR 5424 — A0123 Evaluation of a protocol for isolation and expansion of murine and rat lacrimal gland mesenchymal stem cells. Mathias Roth, A. Kunze, G. Geerling, S. Schrader. Ophthalmology, University of Düsseldorf, Düsseldorf, Germany *CR 5425 — A0124 Long-Term Outcomes of Patients with Ocular Surface Stem Cell Transplant: 20 years follow-up. Kunal Suri, S. C. Kaufman. Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN *CR 5426 — A0125 Mild-moderate dry eye patients exhibit ocular surface temperature lower than normal subjects. Giuseppe Giannaccare, P. Versura, M. Grillini, E. C. Campos. Ophthalmology Unit, DIMES Department, Alma Mater Studiorum University of Bologna and S.Orsola-Malpighi Teaching Hospital, Bologna, Italy 5427 — A0126 Ocular Surface Changes in Glaucomatous Patients Treated with and without Preservatives beta-Blockers. Serena Telani1, M. M. Iester1, P. Frezzotti2, M. Figus3, P. Fogagnolo4, A. Perdicchi5, A. Ferreras6, C. Traverso1. 1University Eye Clinic, Genova, Italy; 2University Eye Clinic, Siena, Italy; 3University Eye Clinic, Pisa, Italy; 4 University Eye Clinic, Milano, Italy; 5University Eye Clinic, La Sapienza, Rome, Italy; 6Univerisity Eye Clinic, Zaragoza, Spain *CR 5428 — A0127 Ocular surface findings associated to clinical signs of hyperandrogenism assessed by an innovative videodermoscopic method. Ilaria Macchi1, L. Guccione2, F. Mantelli1, A. Micera3, C. G. Moretti2, S. Bonini1. 1 Ophthalmology, Campus Biomedico Unversity, Rome, Italy; 2Endocrinology, San Giovanni Calibita Fatebenefratelli Hospital, Rome, Italy; 3IRCCS GB Bietti, Rome, Italy *CR, f 5429 — A0128 PROSE treatment for Ocular Surface Disease in patients with history of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. Thanos D. Papakostas1, H. Le2, J. Chodosh1, D. S. Jacobs2, 1. 1Ophthalmology, Massachusetts Eye & Ear Infirmary, Boston, MA; 2 Boston Foundation for Sight, Needham, MA *CR 5430 — A0129 Assessment of the EyePRIM Device for Conjunctival Impression for Flow Cytometry. Paul J. Tomlins1, P. Roy2, J. Curnow1, S. Rauz1. 1Centre for Translational Inflammation Research, University of Birmingham, Birmingham, United Kingdom; 2Opia Technologie, Paris, France *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 348 Thursday – Posters – 5431 – 5455 5431 — A0130 Relationships of meibomian gland dysfunction and cardiovascular disease risk factors in a middle-aged population. HungChi Chen1, 2, C. Chen2, H. Chen3, Y. Hwang1, 2, H. Lin1, D. H. Ma1. 1Ophthalmology, Chang Gung Memorial Hospital, Taoyuan County, Taiwan; 2 Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan; 3Internal Medicine, Taipei City Hospital-Heping Branch, Taipei, Taiwan 5440 — A0139 Extended Soft Bandage Contact Lenses Therapy for Ocular Graft-VersusHost Disease. Yichen Sun1, 4, Y. Inamoto3, J. P. Sheehan1, P. Li2, R. K. Wang1, 2, S. Lee3, T. T. Shen1, 2. 1 Ophthalmology, University of Washington, Seattle, WA; 2Bioengineering, University of Washington, Seattle, WA; 3Fred Hutchinson Cancer Research Center, Seattle, WA; 4Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan *CR, f 5449 — A0148 A Plaque Method for Direct and Sensitive Enumeration of Surviving Acanthamoeba During Biocidal Efficacy and Regimen Testing of Contact Lens Disinfection Solutions. Shawn C. Lynch, J. G. Carr, C. Kovacs, M. A. Dehmler, T. Bassage, W. Haas, T. W. Morris. Bausch & Lomb, Rochester, NY *CR 5441 — A0140 Three-dimensional volumetric reconstruction of the mouse diabetic cornea. Danielle M. Robertson1, M. Petroll1, M. Zhu1, V. Koppaka1, 2. 1Ophthalmology, Univ Texas Southwestern Med Ctr, Dallas, TX; 2Pharmacy, University of Colorado Denver, Denver, CO 5450 — A0149 Atypical Pathogens Observed in Recent Clinical Studies of Bacterial Conjunctivitis. Lynne S. Gearinger1, C. M. Sanfilippo1, L. Zhang2, W. Haas1, T. L. Comstock3, T. W. Morris1. 1Microbiology and Sterilization Sciences, Bausch & Lomb, Inc, Rochester, NY; 2 Global Clinical Operations, Bausch & Lomb, Inc, Rochester, NY; 3Global Medical Affairs, Bausch & Lomb, Inc, Rochester, NY *CR, f 5442 — A0141 Rat Exorbital Lacrimal Gland Ducts Have Gastrin Receptors. Mortimer Lorber1, E. C. Permaul2, S. Sen2, D. Berry2. 1 Pharmacology & Physiology, Georgetown Univ School of Medicine, Washington, DC; 2Lombardi Comprehensive Cancer Center, Georgetown Univ School of Medicine, Washington, DC 5451 — A0150 A Parallel-Group Study Evaluating the Safety and Efficacy of BrimonidineTartrate 0.025% Ophthalmic Solution in a Population of Adult and Geriatric Subjects. Gerald Horn1, M. J. Chapin2, P. J. Gomes2. 1Eye Therapeutics, Schaumburg, IL; 2Ora, Inc, Andover, MA *CR, f 5434 — A0133 Prevention, Prophylaxis, and Treatment of Ocular Surface Disease in a Tertiary Care Inpatient Setting: Identifying Patients at Risk. Jesse T. McCann, I. Belinsky, L. Park. NYU Medical Center, New York, NY 5443 — A0142 Changes in corneal innervations after herpes simplex virus type 1 (HSV-1) latency established with different reactivation phenotypes. Jiucheng He1, 2, R. Cosby1, 2, J. M. Hill1, 2, H. E. Bazan1, 2. 1Ophthalmology & Neuroscience Ctr, LSU Health Sciences Center, New Orleans, LA; 2LSU Eye Center, LSU Health Sciences Center, New Orleans, LA 5435 — A0134 Risk Factors of Severe Acanthamoeba Keratitis. Machiko ShimmuraTomita, H. Takano, N. Kinoshita, F. Toyoda, A. Ota, A. Kakehashi. Ophthalmology, Jichi Medical University Saitama Medical Center, Saitama, Japan 5444 — A0143 Assessment of the Eyeprim® Device for Conjunctival Impression and PCR. Pierre Roy1, H. Groux2, F. Cottrez2, L. Protat1. 1OPIA Technologies SAS, Paris, France; 2 IMMUNOSEARCH, Grasse, France *CR 5452 — A0151 Evolution in post transplant patients with Herpetic Keratitis in Hospital Fundacion Nuestra Señora de la Luz. cristina C. fernandez1, C. Pacheco-Del-Valle2, A. Babayan3, O. Baca4, R. Velasco5. 1cornea, Hospital Fundacion Nuestra Señora de la Luz, Distrito Federal, Mexico; 2 cornea, Hospital Fundacion Nuestra Señora de la Luz, Distrito Federal, Mexico; 3cornea, Hospital Fundacion Nuestra Señora de la Luz, Distrito Federal, Mexico; 4cornea, Hospital Fundacion Nuestra Señora de la Luz, Distrito Federal, Mexico; 5 cornea, Hospital Fundacion Nuestra Señora de la Luz, Distrito Federal, Mexico 5436 — A0135 Evaluation of different applicator-systems for autologous serum eyedrops. Alexander Kunze, K. Spaniol, G. Geerling. Ophthalmology, University Hospital Duesseldorf, Duesseldorf, Germany *CR 5445 — A0144 Classification of the ocular surface manifestations in patients with StevensJohnson Syndrome. Tais H. Wakamatsu, M. S. Santos, T. P. Barreiro, C. C. Farias, F. E. Hirai, J. A. Gomes. Ophthalmology, Federal University of São Paulo, Sao Paulo, Brazil *CR 5432 — A0131 Antibacterial Activity of Lysozyme in Hyperosomolar Conditions. Poonam Mudgil, J. Whitehall. School of Medicine, University of Western Sydney, Penrith, NSW, Australia 5433 — A0132 Treatment of Ocular Surface Failure Due to Limbal Stem Cell Deficiency by Cultivated Limbal Epithelial Cell Transplantation (CLET). Beatriz Eugenia E. Ramirez Villagran1, M. F. Pastor3, J. M. Herreras1, 2, I. Pérez1, J. García-Sancho3, A. Sanchez3, M. Calonge1, 2. 1Ocular Surface Group, IOBA-University of Valladolid, Valladolid, Spain; 2 CIBER-BBN (Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine), Spain, Spain; 3IBGM-University of Valladolid, Valladolid, Spain *CR 5438 — A0137 Cytokine tear film expression in patients with primary and recurrent pterygium. Victor M. Bautista, N. Rangel-Acosta, N. LópezEspinosa, A. Nava-Castañeda. Microbiology and Ocular Proteomics, Inst de Ophthal Conde de Valenciana, Mexico, Mexico 5439 — A0138 Effectiveness and safety of intralesional injection of 0.01 mg Mitomycin C one month prior to bare sclera excision for pterygium treatment. Brian Tieu, M. Kapur. UTMB, Galveston, TX 5446 — A0145 Ocular surface in Sjögren’s syndrome. Hayette Rebika1, S. Lazreg2. 1CHU Clermont Ferrand, Clermont Ferrand, France; 2 Cabinet Dr Lazreg, Blida, Algeria Thursday, May 09, 2013 8:30 AM-10:15 AM Cornea / Visual Psychophysics / Physiological Optics 506 Contact Lens II Moderators: J. Martin Heur and Vasile Diaconu 5447 — A0146 Treatment of Ocular cGVHD with PRP: a confocal microscopy study. Marco Marenco1, E. Gerace1, A. Plateroti1, C. Colica1, G. Ferrazza2, L. De Felice2, E. M. Vingolo1, M. Gharbiya1, R. Plateroti1. 1Ophthalmology, Sapienza University of Roma, Rome, Italy; 2Hematology, Sapienza University of Roma, Rome, Italy 5453 — A0152 Corneal confocal and topographical changes with use of rigid contact lens in keratoconus patients following collagen cross linking. Sri Vatsa Sehra, J. S. Titiyal, R. Tandon, N. Sharma, R. Sinha. Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India 5448 — A0147 Angiogenin is a Requirement for Active Stromal tissue Formation and Recurrence of Pterygium. Jae Chan Kim, K. Kim, S. Park, Y. Chun, S. Wee. Department of Ophthalmology, Chung-Ang University Hospital, Seoul, Republic of Korea 5454 — A0153 Is the Use of an Integrating Sphere Really Desirable When Measuring Contact Lens Transmittance? Claude J. Giasson1, 2, C. Deschênes1, V. Diaconu1. 1School of Optometry, University of Montreal, Montreal, QC, Canada; 2LOEX, CHA, Quebec, QC, Canada 5455 — A0154 Peripheral Defocus with Spherical and Bifocal Soft Contact Lenses. David A. Berntsen, C. E. Kramer. College of Optometry, University of Houston, Houston, TX *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 349 Thursday Posters 8:30 am – 10:15 am 5437 — A0136 Standardized Quantification of Inflammatory Biomarker HLA-DR for Multicenter Clinical Trials of Ocular Surface Disease. Penny A. Asbell1, S. P. Epstein1, N. Gadaria-Rathod1, Y. Wei1, M. G. Maguire2. 1 Ophthalmology, Mount Sinai School of Medicine, New York, NY; 2Ophthalmology, University of Pennsylvania, Philadelphia, PA *CR Exhibit Hall A0152-A0189 5456 – 5478 – Thursday – Posters 5456 — A0155 Functional and visual improvement with Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) scleral lenses for irregular corneas. Jennifer C. Lee, G. B. Chiu, D. Bach, S. R. Bababeygy, J. A. Irvine, J. M. Heur. Ophthalmology, Doheny Eye Institute at Keck School of Medicine of the University of Southern California, Los Angeles, CA 5463 — A0162 Optical Path Length Quantification of Soft Contact Lens Parameter Changes During Dehydration. Pete S. Kollbaum1, D. Iskander2, R. McGiffen1, M. E. Jansen1. 1 Optometry, Indiana University, Bloomington, IN; 2Institute of Biomedical Engineering and Instrumentation, Wroclaw University of Technology, Wroclaw, Poland *CR 5473 — A0172 Ocular Signs and Symptoms in Contact Lens Wearers in a Controlled Low Humidity Environmental Exposure Chamber (LH-EEC), A Natural Provocation Research Model. Piyush Patel1, F. Soong1, J. P. Varikooty2, N. J. Keir2, L. W. Jones2. 1Inflamax Research, Mississauga, ON, Canada; 2CCLR, University of Waterloo, Waterloo, ON, Canada *CR 5457 — A0156 Migrating versus Stationary Pressure Experiments in Lubricity Measurements of Hydrogels. Alison C. Dunn1, J. M. Uruena1, J. Pruitt2, T. E. Angelini1, W. G. Sawyer1. 1Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL; 2Biocompatibility Projects, Alcon Vision Care Research, Johns Creek, FL *CR 5464 — A0163 A Novel Approach for Data Collection Evaluating Doctor and Patient Preferences for Wearing a Daily Disposable Contact Lens for Astigmatism. W L. Ball. PDMA, Johnson & Johnson, Jacksonville, FL *CR 5474 — A0173 Correction of infant aphakia after cataract surgery with rigid gas-permeable contact lenses. Anja K. Gruenert1, M. Klueppel3, J. Hausser4, T. Reinhard2, R. Sundmacher1, T. Guthoff1, T. A. Fuchsluger1, G. Geerling1. 1 Department of Ophthalmology, Heinrich-HeineUniversity, Duesseldorf, Germany; 2Department of Ophthalmology, University of Freiburg Hospital, Freiburg, Germany; 3Practice, Moers, Germany; 4 Practice, Duesseldorf, Germany *CR 5458 — A0157 Struggle with Soft Contact Lens Wear Addressed by Refitting with Daily Disposable Lenses. Robin L. Chalmers, S. B. Hickson-Curran, L. J. Keay, W. Gleason, R. Albright. Clinical Trial Consultant, Atlanta, GA *CR, f 5459 — A0158 In vivo confocal microstructural analysis of corneal epithelial cell changes related to daily wear use of silicone hydrogel contact lenses. Jessica Lee1, X. Zhang1, C. Marchetti1, Y. Jiang2, Y. Sun1, S. M. Debanne2, J. Lemp3, B. Benetz1, P. Eric1, L. B. Szczotka-Flynn1. 1 Ophthalmology, University Hospitals Case Medical Center, Cleveland, OH; 2Epidemiology & Biostatistics, University Hospitals Case Medical Center, Cleveland, OH; 3Alcon Laboratories, Fort Worth, TX *CR, f Thursday Posters 8:30 am – 10:15 am 5460 — A0159 The relationship between clinical grading and objective image analysis of Lid Wiper Epitheliopathy. Jalaiah P. Varikooty1, B. J. Lay3, N. J. Keir1, H. Burdin3, L. W. Jones1, T. L. Simpson2, J. Lemp4. 1CCLR, School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada; 2School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada; 3 ADCIS, Baltimore, MD; 4Global Medical Affairs, R&D, Alcon, Fort Worth, TX *CR, f 5461 — A0160 Corneal Stroma and Endothelial Cell Changes in Contact Lens Wearers Visualized with Confocal Microscopy. Christine Marchetti1, J. Lee1, X. Zhang1, Y. Sun1, S. M. Debanne1, Y. Jiang1, J. R. Kern2, B. Benetz1, E. Pearlman1, L. B. Szczotka-Flynn1. 1Ophthalmology, University Hospitals Case Western Reserve, Cleveland, OH; 2Alcon Laboratories, Fort Worth, TX *CR, f 5462 — A0161 The effect of recovery periods on end of day comfort. Ulrike Stahl1, N. J. Keir1, J. P. Varikooty1, K. Nandakumar1, A. J. Keech1, A. Landers2, L. W. Jones1. 1School of Optometry and Vision Science, Centre for Contact Lens Research, Waterloo, ON, Canada; 2Alcon Vision Care, Duluth, GA *CR, f 5465 — A0164 Visual Correction for Irregular Corneas with Scleral Lenses. Muriel Schornack, C. B. Nau, J. Pyle, S. V. Patel. Ophthalmology, Mayo Clinic, Rochester, MN 5466 — A0165 Visual Performance and Residual Aberration in Keratoconus Subjects Wearing Custom Scleral Contact Lenses. Jason D. Marsack, C. Nguyen, D. E. Koenig, A. Ticak, J. D. Elswick, R. A. Applegate. Optometry, University of Houston, Houston, TX *CR 5467 — A0166 Direct comparison between in situ versus extraction techniques for measuring adsorbed proteins: application to lysozyme deposited onto hydrogel contact lenses. Brad Hall, C. Phan, L. N. Subbaraman, L. W. Jones, J. A. Forrest. University of Waterloo, Waterloo, ON, Canada *CR 5468 — A0167 PRG4 as a Natural Boundary Lubricant for Commercial Silicone Hydrogel Contact Lenses. Michael L. Samsom1, A. Chan1, L. W. Jones2, T. A. Schmidt1. 1Biomedical Engineering, University of Calgary, Calgary, AB, Canada; 2 School of Optometry, University of Waterloo, Waterloo, ON, Canada *CR 5469 — A0168 Decreased Clearance between Scleral Contact Lens and Cornea after 2 Hours of Lens Wear. Cherie B. Nau, M. Schornack. Ophthalmology, Mayo Clinic, Rochester, MN 5470 — A0169 Multivariate Statistical Analysis Examining and Modeling Drug Release from Contact Lens Materials. Frances Lasowski, G. Guidi, H. Sheardown. Chemical Engineering, McMaster University, Hamilton, ON, Canada *CR 5471 — A0170 A study of the feasibility of fitting custom designed contact lenses to guinea pigs, guided by AS-OCT imaging and corneal topography. Yue Liu1, Z. Chen2, C. F. Wildsoet1. 1VIsion Science, Univ of CA, Berkeley Sch of Optometry, Berkeley, CA; 2Department of Ophthalmology & Vision Science, Eye & ENT hospital,Fudan University, Shanghai, China *CR 5475 — A0174 The evaluation of Lid Wiper Epitheliopathy in contact lens wearers in a Controlled Low Humidity Environmental Exposure Chamber. Lyndon W. Jones1, J. P. Varikooty1, N. J. Keir1, F. Soong2, P. Patel2. 1CCLRSchool of Optometry, University of Waterloo, Waterloo, ON, Canada; 2Inflamax Research, Mississauga, ON, Canada *CR 5476 — A0175 Determination of Oxygen Permeability of Soft Contact Lenses Using Polarographic Lens Stacking and Single-Lens with Various Powers. X Michael Liu, G. L. Oltean. Global R&D, Bausch & Lomb, Rochester, NY *CR 5477 — A0176 The Large-Scale Epidemiological Study on the Prescription of Contact Lenses in Japan -The Result from Analyzing approximately 330,000 Eyes of Japanese Subjects-. Eiichi Okada1, N. Mizuki2, T. Kawagoe2, M. Nagasaki1, N. Matsunaga3, M. Yoshida3. 1Okada Eye Clinic, Yokohama, Japan; 2 Department of Ophthalmology, Yokohama City University, School of Medicine, Yokohama, Japan; 3 Department of Public Health, Kyorin University, School of Medicine, Mitaka, Japan 5478 — A0177 Comparative study of refractive change between glasses and contact lenses users -5 years prospective study against approximately 273 thousand Japanese eyes-. Masao Yoshida1, N. Mizuki2, T. Kawagoe2, M. Nagasaki3, N. Matsunaga1, E. Okada3. 1Department of Public Health, Kyorin University School of Medicine, Mitaka, Japan; 2Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Japan; 3Okada Eye Clinic, Yokohama, Japan 5472 — A0171 Investigation of Latanoprost Release from Contact Lens Materials Using in vitro Cell Models. Saman Mohammadi1, L. W. Jones2, 3, M. Gorbet1, 3. 1Systems Design Engineering, University of Waterloo, Waterloo, ON, Canada; 2School of Optometry, University of Waterloo, Waterloo, ON, Canada; 3Centre for Contact Lens Research, University of Waterloo, Waterloo, ON, Canada *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 350 Thursday – Posters – 5479 – 5498 5479 — A0178 Risk Factors for microbial bioburden during daily wear of silicone hydrogel contact lenses. Ying Jiang1, M. Jacobs2, S. Bajaksouzian2, A. Foster2, S. M. Debanne1, R. Bielefeld3, M. Garvey3, S. Raghupathy Bsoptom4, J. R. Kern5, L. B. Szczotka-Flynn4. 1Department of Epidemiology & Biostatistics, Case Western Reserve Rniversity, Cleveland, OH; 2Department of Pathology, Case Western Reserve University, Cleveland, OH; 3Division of Information Technology Services, Case Western Reserve University, Cleveland, OH; 4Department of Ophthalmology & Visual Sciences and University Hospitals Eye Institute, University Hospitals Case Medical Center, Cleveland, OH; 5Alcon Laboratories, Fort Worth, TX *CR, f 5480 — A0179 An Examination of the Effects of Evaporation on Antimicrobial Efficacy of Contact Lens Care Solutions. Nancy Brady, M. Milenkovic, A. Lam. Corneal Microbiology, Abbott Medical Optics, Santa Ana, CA *CR 5481 — A0180 Evaluation of an auto-refractor for over-refraction with multifocal contact lenses patients. Anna Giner2, M. Aldaba2, M. Arjona1, J. Pujol1. 1CD6 - Optica i optometria, Polithechnical University of Catalonia, Terrassa, Spain; 2CD6, Polithechnical University of Catalonia, Terrassa, Spain *CR 5482 — A0181 Evaluation of the effect of soft contact lens edge shape on conjunctival epithelium. Dorota H. Szczesna-Iskander1, D. Iskander2. 1Institute of Physics, Wroclaw University of Technology, Wroclaw, Poland; 2Institute of Biomedical Engineering And Instrumentation, Wroclaw University of Technology, Wroclaw, Poland *CR 5486 — A0185 Effect of Static and NonStatic in-vitro Techniques on Lipid Penetration Into SiHy Contact Lenses. Jean T. Jacob1, 2, R. Frederick1, 2, C. Tucker1, 3, L. Love1, 4. 1Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA; 2Biomedical Engineering, Tulane University, New Orleans, LA; 3University of New Orleans, New Orleans, LA; 4Xavier University, New Orleans, LA *CR 5487 — A0186 Visual Performance and Optical Quality with New Silicone-hydrogel Soft Contact Lenses for Keratoconus. Asaki Suzaki1, N. Maeda2, M. Fuchihata2, S. Koh2, K. Nishida2, T. Fujikado1. 1 Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan; 2Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan *CR 5488 — A0187 In-Vitro Spoilation of SiHy Soft Contact Lenses using LAESI-MS and FCSLM. Trust T. Razunguzwa1, H. Goodman1, C. Peng2, N. Fajardo2, C. J. Radke2. 1Protea Biosciences Group Inc., Morgantown, WV; 2Chemical and Biomolecular Engineering, University of California, Berkeley, CA *CR 5489 — A0188 Tear Film Proteins StronglyAdherent to a Non-Ionic Silicone Hydrogel Contact Lens Across the Wear Cycle. Michael S. Foster, A. Landers, M. M. Gabriel, J. D. Lane, W. L. Nash. Vision Care, Alcon, Duluth, GA *CR 5490 — A0189 Objective Visual Performance of Low-add Multifocal Contact Lenses. Balamurali Vasudevan, S. N. Gaib. Optometry, Midwestern University, Glendale, AZ *CR Exhibit Hall B0001-B0052 5483 — A0182 The Cause of Midday Visual Fogging in Scleral Gas Permeable Lens Wearers. Anna McKinney1, W. L. Miller1, N. E. Leach1, C. Polizzi1, E. van der Worp2, J. P. Bergmanson1. 1 University of Houston College of Optometry, Houston, TX; 2Maastricht University, Maastricht, Netherlands *CR Thursday, May 09, 2013 8:30 AM-10:15 AM 5484 — A0183 Designing Multifocal Contact Lenses using a Novel Through-Focus Image Quality Metric Highly Correlated with Clinical Visual Acuity. Nishant Mohan, A. C. Kingston, I. G. Cox. Bausch and Lomb, Rochester, NY *CR Moderator: Delia DeBuc 507 Image Processing and Segmentation Algorithms 5491 — B0001 Using Asymmetry Analysis to Reduce Normal Variability of Spectral Domain Optical Coherence Tomography (SD-OCT) Macular Thickness. Muhammed S. Alluwimi, W. H. Swanson, V. Malinovsky. School of Optometry, Indiana University Bloomington, Bloomington, IN 5492 — B0002 Comparison and normalization of retinal reflectivity profiles between spectraldomain optical coherence tomography devices. Zhihong Hu, M. Nittala, S. Sadda. Retina, Doheny Eye Institute, Arcadia, CA *CR 5494 — B0004 An automated system for the detection of AMD-related drusen in retinal fundus images. Damon Wong1, J. Liu1, F. Yin1, J. Zhang2, N. Tan1, M. Bhargava3, G. C. Cheung3, T. Y. Wong3. 1Insittute for Infocomm Research, Singapore, Singapore; 2Nanyang Technological University, Singapore, Singapore; 3Singapore Eye Research Insttute, Singapore, Singapore *CR 5495 — B0005 Automated quantification of drusen and choroid using clinical SD-OCT. Li Zhang1, G. H. Buitendijk3, 4, K. Lee1, A. Wahle1, M. Sonka1, 2, C. C. Klaver3, 4, M. D. Abramoff2, 5. 1 Electrical And Computer Engineering, University of Iowa, Iowa City, IA; 2Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA; 3 Department of Ophthalmology, Erasmus Medical Center, Rotterdam, Netherlands; 4Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands; 5Veterans Affairs, Iowa City VA Medical Center, Iowa City, IA *CR 5496 — B0006 Automatic Drusen Quantification and Risk Assessment of Agerelated Macular Degeneration on Color Fundus Images. Mark J J P van Grinsven1, Y. T. Lechanteur2, J. P. van de Ven2, B. van Ginneken1, C. B. Hoyng2, T. Theelen2, C. I. Sanchez1. 1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands *CR 5497 — B0007 Tissue, microscopy, and computational techniques for mapping human retinal pigment epithelium cell number and autofluorescence. Thomas Ach1, J. D. Messinger1, M. J. Bentley2, F. C. Delori3, K. R. Sloan2, C. A. Curcio1. 1Dept of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL; 2 Computer and Information Science, University of Alabama at Birmingham, Birmingham, AL; 3 Ophthalmology, Schepens Eye Research Institute, Boston, MA 5498 — B0008 A Multimodal MachineLearning-Based Approach for Segmenting the Optic Disc and Cup in Fundus and SDOCT Images. Mohammad Saleh Miri1, 2, M. D. Abramoff2 3, K. Lee1, M. Niemeijer1, A. Wahle1, Y. H. Kwon3, M. K. Garvin2, 1. 1Electrical and Computer Engineering, The University of Iowa, Iowa City, IA; 2 Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, IA; 3The Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 351 Thursday Posters 8:30 am – 10:15 am 5485 — A0184 Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) Treatment: A Partner Clinic Experience. Kira L. Segal1, M. N. Lee2, K. O. Chapman2, M. Rosenblatt2, K. C. Sippel2, C. E. Starr2, J. Ciralsky2. 1Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; 2Ophthalmology, NewYork-Presbyterian, New York, NY Multidisciplinary Ophthalmic Imaging 5493 — B0003 Retinal Central Reflex Quantification: A New Approach for Central Reflex Grading and Severity Measurement. Alauddin Bhuiyan1, E. L. Lamoureux2, J. Wang3, C. Y. Cheung2, K. Yogesan1, T. Y. Wong2. 1Australian E-Health Research Centre, Commonwealth Scientific &Industrial Research Organization, Floreat, WA, Australia; 2Singapore Eye Research Institute, Singapore, Singapore; 3University of Sydney, Sydney, NSW, Australia *CR 5499 – 5517 – Thursday – Posters 5499 — B0009 Automated segmentation of the in-vivo lamina cribrosa (LC) imaged using 3D optical coherence tomography (OCT). Bo Wang1, 2, Z. Nadler1, J. E. Nevins1, R. A. Bilonick1, 3, H. Ishikawa1, 4, L. Kagemann1, 4, I. Grulkowski5, J. J. Liu5, J. G. Fujimoto5, J. S. Schuman1, 4. 1UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA; 2Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA; 3 Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA; 4Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA; 5Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA *CR 5500 — B0010 Automated Choroidal Segmentation in 1µm Swept Source Deep Range Imaging OCT. Qi Yang1, C. A. Reisman1, R. Ramachandran2, A. S. Raza2, D. C. Hood2, 3, K. Chan1. 1Topcon Adv Biomed Imaging Lab, Topcon Medical Systems, Oakland, NJ; 2 Psychology, Columbia University, New York, NY; 3 Ophthalmology, Columbia University, New York, NY *CR 5501 — B0011 SD OCT Analysis of Retinal Zones Identified as Abnormal with UltraWidefield Autofluorescence. Jerome Sherman1, 2, D. Epshtein1, S. Nath3, 4, S. Slotnick1, 2. 1Clinical Sciences, SUNY College of Optometry, New York, NY; 2SUNY Eye Institute, State University of New York, NY, NY; 3Eye Institute and Laser Center, New York, NY; 4NY Eye and Ear Infirmary, New York, NY *CR Thursday Posters 8:30 am – 10:15 am 5502 — B0012 Validation of the Precision of a Novel Representation of Images Obtained by the Optos P200Tx Ultra Wide-Field Imaging System. Natasha Maqsood1, R. Sophie1, J. van Hemert2, D. Swan2, M. Verhoek2, M. G. Bittencourt1, D. A. Ferraz1, H. Jang1, Y. J. Sepah1, Q. Nguyen1. 1 Retinal Imaging Research and Reading Centre, Johns Hopkins University, Baltimore, MD; 2Optos, Dunfermline, United Kingdom *CR 5503 — B0013 Total Retinal Thickness Using Iowa Reference Algorithm: Measurement Reproducibility in 5 SD-OCT Scanners. Adnan Rashid1, U. Schmidt-Erfurth4, 5, B. S. Gerendas5, S. M. Waldstein6, H. Bogunovic1, A. Wahle1, C. Simader6, K. Lee1, M. Sonka1, 2, M. D. Abramoff2, 3. 1 Electrical and Computer Engineering, The University of Iowa, Iowa City, IA; 2Ophthalmology and Visual Sciences, The university of Iowa, Iowa City, IA; 3Veterans Affairs, Medical Center, Iowa City, IA; 4Department of Ophthalmology, Medical University of Vienna, Vienna, Austria; 5 Ophthalmology & Optometry, Med Univ Vienna, Vienna Gen Hosp, Vienna, Austria; 6Vienna Reading Center, Department of Ophthalmology, University of Vienna, Vienna, Austria *CR 5504 — B0014 Fully Automatic Risk Assessment Of Diabetic Retinopathy In Digital Fundus Images. E Simon Barriga1, 2, C. Agurto1, H. Yu1, V. Joshi1, C. Carranza2, J. Wigdahl1, S. C. Nemeth1, G. Zamora1, W. C. Bauman3, P. Soliz1, 4. 1 VisionQuest Biomedical LLC, Albuquerque, NM; 2 Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM; 3Retina Institute of South Texas, San Antonio, TX; 4Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA *CR 5510 — B0020 Automated choroidal neovascularization associated abnormality detection and quantitative analysis from clinical SD-OCT. Xiayu Xu1, L. Zhang1, K. Lee1, A. Wahle1, X. Chen3, X. Wu1, M. D. Abramoff1, 2, M. Sonka1. 1Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA; 2 Ophthalmology & Visual Sciences, University of Iowa, Iowa City, IA; 3School of Electronics and Information Engineering, Soochow University, Soochow, China *CR 5505 — B0015 Correlation between Fluorescein Leakage Maps Generated by Automated Leakage Quantification of Fluorescein Angiogram and Retinal Thickness Maps Created by OCT in Eyes with Neovascular AMD. Mostafa Hanout1, E. Magdy2, O. O. Agbedia1, M. A. Ibrahim1, M. G. Bittencourt1, M. A. sadiq1, D. Ferraz1, A. Moradi1, A. S. Fahmy2, 3, Q. Nguyen1. 1 Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD; 2Center for Informatics Science, Nile University, Cairo, Egypt; 3Systems of Biomedical Engineering Department, Cairo University, Cairo, Egypt *CR 5511 — B0021 A new computer-assisted image processing technique for quantitative analysis of the impact of pterygia on refractive indices and ocular higher-order aberrations. Koray Gumus1, A. Guven2, M. Guler2, M. Gerdan1. 1 Department of Ophthalmology, Erciyes University School of Medicine, Kayseri, Turkey; 2Biomedical Engineering Faculty, Erciyes University, Kayseri, Turkey 5506 — B0016 Semi-automated Contour Analysis of SD-OCT images after Epiretinal Membrane Peeling using either air tamponade or balanced salt solution. Focke Ziemssen, M. Leitritz, D. Zobor, M. Voelker, K. Bartz-Schmidt, F. Gelisken. Center of Ophthalmology, University Tuebingen, Tuebingen, Germany *CR 5507 — B0017 A Fully Automatic Framework for Segmentation and Localization of Retinal Structures in Fundus Images. Attila Budai1, 2, K. Mogalle1, K. Laurik4, J. M. Hornegger1, 2, G. Michelson3. 1Pattern Recognition Lab, University of Erlangen-Nuremberg, Erlangen, Germany; 2 Erlangen Graduate School in Advanced Optical Technologies, Erlangen, Germany; 3 Interdisciplinary Center of Ophthalmic Preventive Medicine and Imaging (IZPI), Erlangen, Germany; 4 Department of Ophthalmology, Semmelweis University, Budapest, Hungary *CR 5508 — B0018 Reliability of automatic measurements for thickness profiles of intraretinal layers using ultra-high resolution optical coherence tomography. Xinting Liu, M. Shen, S. Huang, D. Zhu, L. Leng, F. Lu. Wenzhou Medical College, Wen Zhou, China 5509 — B0019 Automatic Segmentation of OCT Datasets Using Superpixels-Classification. Pascal A. Dufour1, 2, H. Abdillahi3, 2, L. Ceklic3, 2, U. E. Wolf-Schnurrbusch3, 2, S. Wolf2, J. H. Kowal1, 2. 1 Ophthalmic Technologies ARTORG Center, University of Bern, Bern, Switzerland; 2Department of Ophthalmology, University Hospital Bern, Bern, Switzerland; 3Bern Photographic Reading Center, University Hospital Bern, Bern, Switzerland *CR 5512 — B0022 Choroidal Thickness in AgeRelated Macular Degeneration as measured by Semi-Automated Segmentation of the Choroid in Enhanced-Depth Imaging Optical Coherence Tomography. Glenn Yiu1, S. Fekrat1, N. Sarin1, S. J. Chiu2, S. Stinnett1, S. Farsiu1, 2, C. A. Toth1, 2. 1 Ophthalmology, Duke University Medical Center, Durham, NC; 2Biomedical Engineering, Duke University, Durham, NC *CR 5513 — B0023 Clinical Utility of Thresholding Segmentation in Ultra-Widefield (Optos®) Fundus Autofluorescence Images. Sarah MacIver1, J. Sherman2, 3, N. Hutchings1. 1Univ of Waterloo Sch of Optom, Waterloo, ON, Canada; 2 Clinical Sciences, SUNY State College of Optometry, New York, NY; 3SUNY Eye Institute, State University of New York, New York, NY *CR 5514 — B0024 Reliability of Automated Leakage Quantification of Fluorescein Angiography in Eyes with Diabetic Macular Edema. Owhofasa O. Agbedia1, E. Magdy2, M. A. Ibrahim1, Y. J. Sepah1, R. Sophie1, M. G. Bittencourt1, M. Hanout1, D. V. Do1, A. Fahmy2, Q. Nguyen1. 1Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD; 2Center for Informatics Science, Nile University, Giza, Egypt *CR 5515 — B0025 Evaluation of a New Registration Algorithm Using iVue SD-OCT. Jing Cui, B. K. Jang. Optovue, Inc, Fremont, CA *CR 5516 — B0026 Digital Image Grading Tool for Uveitis Clinical Trials. Brian Madow. Ophthalmology, University of South Florida, Tampa, FL 5517 — B0027 Automated correction of 3D acquisitions using a high frequency rotative ultrasound probe. Charly Maindron1, 2, M. Le Loir4 1, B. Cochener4, 1, M. Lamard3, 1. 1LaTIM - UMR 1101, Brest, France; 2Quantel Medical, Cournon d’Auvergne, France; 3Université de Bretagne Occidentale, Brest, France; 4CHU Brest, Service d’ophtalmologie, Brest, France *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 352 Thursday – Posters – 5518 – 5538 5518 — B0028 3D Motion Correction and Signal Improvement in High speed Polarization Sensitive Optical Coherence Tomography. Martin F. Kraus1, 2, A. Dhalla2, J. J. Liu2, K. J. Mohler2, C. D. Lu2, B. Potsaid2, J. M. Hornegger1, D. Huang3, J. G. Fujimoto2. 1Pattern Recognition Lab and SAOT, University Erlangen Nuremberg, Erlangen, Germany; 2Dept. of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA; 3Casey Eye Institute, Oregon Health & Science University, Portland, OR *CR 5519 — B0029 Retinal layer segmentation in a pediatric normal group. Stefan Pelz, H. Wildberger, C. Gerth-Kahlert. Ophthalmology, University of Zurich, Zurich, Switzerland 5520 — B0030 Detection of Neovascularization in Digital Fundus Images Using a Multiscale Analysis Approach. Carla Agurto Rios1, H. Yu1, J. Wigdahl1, V. Murray2, E. Barriga1, W. C. Bauman3, P. Soliz1, 4. 1Research & Development, VisionQuest Biomedical LLC, Albuquerque, NM; 2 Universidad de Ingenieria & Tecnologia, Lima, Peru; 3Retina Institute of South Texas, San Antonio, TX; 4Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa city, IA *CR 5526 — B0036 Spectral Domain OCT individual retinal layering of diabetics with and without retinopathy. Silvia Bini1, S. Vujosevic1, M. Berton1, E. Pilotto1, E. Midena1, 2. 1Department of Ophthalmology, University of Padova, Padova, Italy; 2G.B. Bietti Foundation, IRCCS, Roma, Italy 5527 — B0037 Large Retinal Hemorrhage Detector for Automated Diabetic Retinopathy Screening System. Li Tang1, 2, M. Niemeijer3, M. D. Abramoff1, 2. 1Ophthal & Visual Sciences, University of Iowa, Iowa City, IA; 2Department of Veterans Affairs, Center of Excellence for Prevention of Visual Loss and Blindness, Iowa City, IA; 3IDx LLC, Iowa City, IA *CR 5528 — B0038 Image Registration for Motion Artifact Removal in Retinal Vascular Imaging Using Speckle Variance Fourier Domain Optical Coherence Tomography. Hansford C. Hendargo1, R. Estrada2, S. J. Chiu1, C. Tomasi2, S. Farsiu3, 1 , J. A. Izatt1, 3. 1Biomedical Engineering, Duke University, Durham, NC; 2Computer Science, Duke University, Durham, NC; 3Ophthalmology, Duke University, Durham, NC *CR 5522 — B0032 Multispectral Retinal Image Analysis (MRIA) for the Quantification of Macular Pigment. Antonio Calcagni1, 2, I. Styles2, A. D. Palmer2, Y. Shen2, H. Bartlett1, F. Eperjesi1, J. M. Gibson1, E. Claridge2. 1School of Life and Health Sciences, Aston University, Birmingham, United Kingdom; 2School of Computer Science, University of Birmingham, Birmingham, United Kingdom 5530 — B0040 Automatic Segmentation of Corneal Lamellar Graft Surfaces from LowContrast Optical Coherence Tomography Images. Alec V. Arshavsky1, 3, F. LaRocca2, J. A. Izatt2, 3, A. N. Kuo3, S. Farsiu2, 3. 1East Chapel Hill High School, Chapel Hill, NC; 2Biomedical Engineering, Duke University, Durham, NC; 3 Ophthalmology, Duke University, Durham, NC *CR 5523 — B0033 Automatic Segmentation of Photoreceptors in AOSLO Images Using Graph Theory and Dynamic Programming. Stephanie J. Chiu1, A. M. Dubis2, A. Dubra3, 4, J. Carroll3, 4, J. A. Izatt1, 2, S. Farsiu2, 1. 1Biomedical Engineering, Duke University, Durham, NC; 2Ophthalmology, Duke University, Durham, NC; 3Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 4Biophysics, Medical College of Wisconsin, Milwaukee, WI *CR 5531 — B0041 Automated Segmentation of Sub-Retinal Layers in Age-related Macular Degeneration. Katrina A. Mears1, L. Zhang2, K. Lee2, X. Xu2, M. Sonka1, 2, M. D. Abramoff1, 2. 1 Department of Ophthalmnology and Visual Sciences, University of Iowa Hospitals and Clinids, Iowa city, IA; 2Electrical and Computer Engineering, University Of Iowa, Iowa city, IA *CR 5524 — B0034 Texture-Based Eye Motion Correction for 3D OCT Imaging. Omaima M. Nomir, H. Jiang, J. Wang, D. DeBuc. Ophthalmology, Univ of Miami School of Med, Miami, FL *CR 5525 — B0035 Automated Detection of Hyperreflective Structures Associated with Diabetic Retinopathy using Spectral Domain Optical Coherence Tomography (SD-OCT). David W. Stein1, N. K. Waheed2, M. Adhi2, S. K. Semy1, J. S. Duker2, W. Kuklinski1. 1MITRE, Bedford, MA; 2 Ophthalmology, New England Eye Center, Boston, MA *CR 5532 — B0042 Methods for manual and automated detection of the four outer retinal hyper-reflective bands in optical coherence tomography scans. Douglas Ross1, 2, M. Clark4, P. Godara6, 3, G. McGwin3, R. F. Spaide5, K. R. Sloan2, C. A. Curcio3. 1Mechanical Engineering, UAB, Birmingham, AL; 2Computer and Information Sciences, UAB, Birmingham, AL; 3Ophthalmology, UAB, Birmingham, AL; 4UAB, Birmingham, AL; 5Vitreous Retina Macula Consultants NY, New York, NY; 6Ophthalmology, Eye Institute, Birmingham, AL *CR 5534 — B0044 Novel method for registration and statistical analysis of volumetric retinal OCT data using surface currents. Evgeniy Lebed1, S. Lee1, S. X. Han1, P. Mackenzie3, A. Trouve2, M. V. Sarunic1, M. Beg1. 1Engineering Science, Simon Fraser University, Burnaby, BC, Canada; 2 Centre de Mathématiques et Leurs Applications, Ecole Normale Supérieure, Cachan, France; 3 Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada 5535 — B0045 Signal Normalization Between Non-Averaged and Frame-Averaged Optical Coherence Tomography (OCT) Images. Chieh-Li Chen1, 2, H. Ishikawa1, 2, G. Wollstein1, R. A. Bilonick1, 3, I. A. Sigal1, 2, L. Kagemann1, 2, J. G. Fujimoto4, J. S. Schuman1, 2. 1UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA; 3 Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA; 4Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA *CR 5536 — B0046 Use of super-resolution image reconstruction techniques in optical coherence tomography. David Alonso-Caneiro, S. A. Read, M. J. Collins. Contact Lens and Visual Optics Lab, Queensland University of Technology, Brisbane, QLD, Australia 5537 — B0047 Image Fusion System to Combine Fluorescence Lifetime Imaging of the Retina with Optical Coherence Tomography Imaging. Jens H. Kowal1, 2, P. A. Dufour1, 2, T. Rudolph1, 2, S. Wolf2. 1Ophthalmic Technologies ARTORG Center, University of Bern, Bern, Switzerland; 2Department of Ophthalmology, University of Bern, Bern, Switzerland *CR 5538 — B0048 Volumes of retinal layers measured by spectral-domain optical coherence tomography and public domain software ImageJ. Albert Caramoy1, K. Droge1, B. Kirchhof1, C. B. Hoyng2, S. Fauser1. 1Department of Ophthalmology, University of Cologne, Cologne, Germany; 2Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 353 Thursday Posters 8:30 am – 10:15 am 5521 — B0031 Triangle mesh segmentation and reconstruction of HD 3D OCT data sets for augmented reality simulation purposes. Carl G. Glittenberg, S. Binder. Dept of Ophthalmology, Rudolph Foundation Hospital, Vienna, Austria 5529 — B0039 A computer-aided manual segmentation method for SD-OCT images yields increased inter-grader reproducibility. Yijun Huang1, J. W. Pak1, S. Luo1, J. White1, X. Zhang2, R. P. Danis1. 1Ophthal & Vis Sciences-FUNDUS, University of Wisconsin-Madison, Madison, WI; 2 Department of Psychology, Columbia University, New York, NY *CR 5533 — B0043 Global and Regional Intrasession Test-Retest Variability of Macular Thickness Measurements with Spectral-domain Optical Coherence Tomography with and without Tracking. Elaine Thung, S. Knipping, J. Caprioli, K. Nouri-Mahdavi. Ophthalmology, UCLA Jules Stein Eye Institute, Los Angeles, CA *CR 5539 – 5554 – Thursday – Posters 5539 — B0049 Fully-automated multimodal co-registration of optical coherence tomography to colour fundus photography and fluorescein angiography. Pedro Guimaraes1, P. Rodrigues2, C. F. Lobo2, P. Serranho3, 1, R. Bernardes1, 2. 1IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Portugal; 2CNTM/AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal; 3Mathematics Section, Department of Science and Technology, Open University, Lisbon, Portugal f 5540 — B0050 Automatic Segmentations of Intra-retinal Layers and Optic Nerve Head in UHR-OCT Images Using Dynamic Programming. Shenghai Huang, M. Shen, X. Liu, L. Leng, F. Lu. Wenzhou Medical College, Wenzhou, China 5541 — B0051 Virtual Frame Averaging - A Novel Image Enhancement Method for Three-Dimensional (3D) Optical Coherence Tomography (OCT) Images. Hiroshi Ishikawa1, 2, C. Chen1, 2, G. Wollstein1, L. Kagemann1, 2, I. A. Sigal1, 2, R. A. Bilonick1, 3, J. G. Fujimoto4, J. S. Schuman1, 2. 1UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA; 3Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA; 4Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA *CR Thursday Posters 8:30 am – 10:15 am 5542 — B0052 DTI Fiber tracking Analysis of the visual input to the pallidum in humans: preliminary results. Hachemi Nezzar1, 2, L. J. Sakka3, 2, J. Coste3, 2, J. Gabrillargues4, 2, F. Chiambaretta1, J. Lemaire3, 2. 1Dept of Ophthalmology, CHU Clermont Ferrand, Clermont-Ferrand, France; 2IGCNC EA 3295, Université d’Auvergne, Clermont Ferrand, France; 3 Dept of Neurosurgery, CHU Clermont Ferrand, Clermont Ferrand, France; 4Dept of Radiology, neuroradiology, CHU Clermont Ferrand, Clermont Ferrand, France Exhibit Hall B0053-B0064 Thursday, May 09, 2013 8:30 AM-10:15 AM Visual Psychophysics / Physiological Optics 508 Improving Imaging and Ophthalmic Instrumentation Moderator: Zoran Popovic 5543 — B0053 Stabilized cone imaging with adaptive optics optical coherence tomography. Omer P. Kocaoglu1, R. D. Ferguson2, Z. Liu1, R. S. Jonnal1, Q. Wang1, D. X. Hammer3, D. T. Miller1. 1School of Optometry, Indiana University, Bloomington, IN; 2Physical Sciences Inc., Andover, MA; 3Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD *CR 5544 — B0054 In vivo Imaging of the Human Retinal Pigment Epithelium Cell Mosaic using Short-wavelength Autofluorescence and achromatizing lenses. Alfredo Dubra1, 2, D. H. Scoles3, Y. N. Sulai4. 1Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 2Biophysics, Medical College of Wisconsin, Milwaukee, WI; 3 Biomedical Engineering, University of Rochester, Rochester, NY; 4The Institute of Optics, University of Rochester, Rochester, NY *CR 5545 — B0055 A novel compact optical instrument for the clinical measurement of intraocular light scattering. Onurcan Sahin1, H. S. Ginis2, 1, G. M. Perez3, J. M. Bueno2, P. Artal2. 1Institute of Vision & Optics, University of Crete, Heraklion, Greece; 2Laboratorio de Optica, Universidad de Murcia, Murcia, Spain; 3Voptica SL, Murcia, Spain *CR 5546 — B0056 The Effect of AOSLO Image Distortion on Metrics of Mosaic Geometry. Robert F. Cooper1, Z. Harvey2, M. Dubow3, 4, Y. N. Sulai5, A. Pinhas3, 4, D. H. Scoles6, N. Shah3, R. B. Rosen3, A. Dubra2, 7, J. Carroll2, 8. 1Biomedical Engineering, Marquette University, Milwaukee, WI; 2 Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 3New York Eye and Ear Infirmary, New York, NY; 4Mount Sinai School of Medicine, Mount Sinai Hospital, New York, NY; 5The Institute of Optics, University of Rochester, Rochester, NY; 6 Biomedical Engineering, University of Rochester, Rochester, NY; 7Biophysics, Medical College of Wisconsin, Milwaukee, WI; 8Cell Biology, Medical College of Wisconsin, Milwaukee, WI *CR 5548 — B0058 Evaluation of a Dual-Conjugate Adaptive Optics Clinical Prototype for Retinal Imaging. Zoran Popovic1, J. Thaung1, B. Svensson2, M. Owner-Petersen1. 1Department of Ophthalmology, University of Gothenburg, Mölndal, Sweden; 2Exomed AB, Sollentuna, Sweden *CR 5549 — B0059 AO-OCT Retinal Imaging with 163-Segment Deformable Mirror. Susanna C. Finn1, C. Greiner1, N. Doble1, R. J. Zawadzki2, J. S. Werner2, S. S. Choi1. 1Vision Science, New England College of Optometry, Boston, MA; 2 Ophthalmology & Vision Science, University of California Davis, Davis, CA *CR 5550 — B0060 Use of multiple metrics to describe the parafoveal cone mosaic. Marco Lombardo1, S. Serrao1, P. Ducoli1, G. Lombardo2, 3 1 . Fondazione GB Bietti IRCCS, Rome, Italy; 2 CNR-IPCF Unit of Support Cosenza, Rende, Italy; 3 Vision Engineering, Rome, Italy 5551 — B0061 Improved Sensitivity of Automated Cone Identification in Images of Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO). Keiko Yonezawa1, H. Sonobe1, A. Uji2, S. Ooto2, M. Hangai2, N. Yoshimura2. 1Medical Imaging Project, Canon Inc., Tokyo, Japan; 2Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan *CR 5552 — B0062 Photoreceptors, Retinal Nerve Fibers and Retinal Blood Flow Observation by AOSLO Applied to Wide Diopter Range. Takashi Yuasa1, F. Hirose1, K. Saito1, K. Matsumoto1, H. Sonobe1, A. Uji2, S. Ooto2, M. Hangai2, N. Yoshimura2. 1Medical Imaging Project, Canon Inc., Ohta-ku, Japan; 2Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto City, Japan *CR 5553 — B0063 Compact multimodal adaptive optics imager (MAOI). R. D. Ferguson, M. Mujat, A. Patel, N. Iftimia. Biomedical Imaging Group, Physical Sciences Inc, Andover, MA *CR 5554 — B0064 Use of variable Field Size in AOSLO retinal imaging to improve postprocessing. Ting Luo, G. Huang, T. Y. Chui, S. A. Burns. School of Optometry, Indiana University Blooomington, Bloomington, IN 5547 — B0057 Photoreceptor imaging with in-the-plane adaptive optics optical coherence tomography using toroidal mirrors. Zhuolin Liu, O. P. Kocaoglu, Q. Wang, D. T. Miller. School of Optometry, Indiana University, Bloomington, IN *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 354 Thursday – Posters – 5555 – 5575 Exhibit Hall B0078-B0103 Thursday, May 09, 2013 8:30 AM-10:15 AM Retinal Cell Biology 509 Diabetic Retinopathy and Vascular Biology II Moderators: Michael H. Elliott and M. Elizabeth Hartnett 5555 — B0078 Pleiotropic effects of Dll1RGD in mice oxygen-induced retinopathy. Guorui Dou1, 2, Y. Wang1, H. Han2, X. Zhao2. 1 Ophthalmology, Xijing Hospital, Xian, China; 2 Developmental Biology and Medical Genetics, Fourth Military Medical University, Xian, China 5556 — B0079 Mice lacking Adenylyl Cyclase (AC) 1 and 8 Mimic Supernormal Intraretinal Ion Channel Activity in Light-adapted Diabetic Mice But have No Impairment in Visual Performance. Robin Roberts1, A. C. Conti3, 4, B. A. Berkowitz1, 2. 1Anatomy & Cell Biol, Wayne State Univ Sch of Med, Detroit, MI; 2Ophthalmology, Wayne State University School of Medicine, Detroit, MI, MI; 3Neurosurgery, Wayne State University School of Medicine, Detroit, MI, MI; 4 Research Service, John D. Dingell VA Medical Center, Detroit, MI, MI 5557 — B0080 Detection and Quantification of VEGF, HIF-1α, HIF-2α and TEAD4 Transcripts in the Mouse Model of Oxygen-Induced Retinopathy. Andrew J. Stempel1, C. W. Morgans2, T. Stout1, B. Appukuttan1. 1Ophthalmology, Casey Eye Institute-OHSU, Portland, OR; 2Physiology & Pharmacology, Oregon Health & Science University, Portland, OR *CR 5558 — B0081 Müller Cell Associated Surfactant Protein A Impairs Retinal Endothelial Cell Function. Faizah N. Bhatti1, 2, G. S. Ball1, R. R. Akram1, M. H. Elliott2. 1Neonatal Perinatal Medicine, Univ of Oklahoma Hlth Sci Ctr, Oklahoma City, OK; 2Ophthalmology, Univ of Oklahoma Hlth Sci Ctr, Oklahoma City, OK 5561 — B0084 Quercetin protects retinal vascular degeneration through anti-angiogenic mechanisms in STZ-induced diabetic rats. Binit Kumar1, S. K. Gupta1, B. P. Srinivasan1, T. C. Nag2, S. Srivastava1, R. Saxena3. 1Department of Pharmacology, Ocular Pharmacology Lab, Delhi Institute of Pharmaceutical Sciences & Research, University of Delhi, New Delhi, India; 2Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India; 3Dr R P Centre For Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India 5562 — B0085 Retinal pathology reminiscent of retinopathy of prematurity in a rat model for periventricular leucomalacia. Janina Steck1, C. Blueml2, S. E. Kampmann2, B. Gerstner3, R. F. Maier2, K. Stieger1, B. Lorenz1. 1Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany; 2Department of Pediatrics, PhillipsUniversity, Marburg, Germany; 3Department of Pediatric Cardiology, Justus-Liebig-Universtiy, Giessen, Germany *CR 5563 — B0086 Tweak/Fn14 Pathway is Involved in Retinal Neovascularization. Hossein Ameri1, 2, R. Liu1, Y. Ha1, A. A. Paulucci3, M. Motamedi1, 3, B. F. Godley1, R. G. Tilton1, 4, W. Zhang1, 2. 1Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, TX; 2Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX; 3Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, TX; 4Division of Endocrinology and Stark Diabetes Center, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 5564 — B0087 Kelch like-ECH-associated protein 1 (Keap1) and retinal antioxidant defense in the development of diabetic retinopathy. Qing Zhong, R. A. Kowluru. Ophthalmology, Wayne State Univ/Kresge Eye Inst, Detroit, MI 5565 — B0088 Curcumin-induced MiRNAs Decrease VEGF, VEGFR, and NF-kB Expression in Human Retinal Endothelial Cells (hRECs) Under Hyperglycemic Condition. Annie N. Farrell, E. Y. Hur, J. C. Howell, R. Haque. Department of Ophthalmology, Emory University, Atlanta, GA 5566 — B0089 The combined effect with EPO and VEGF in retinal angiogenesis. Zhihong Yang, H. Wang, Y. Jiang, M. McCloskey, M. Hartnett. Moran Eye Center, Salt Lake City, UT *CR 5567 — B0090 Role of Prorenin Receptor (PRR) and NADPH Oxidase (NOX) in the Regulation of VEGF in ARPE-19 Cells under Hyperglycemic Conditions. Rashidul Haque, P. M. Iuvone, K. S. Choi, D. J. Park, A. N. Farrell, E. Y. Hur. Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 5568 — B0091 Retinal Protease and Collagen Responses to Increasing Numbers of Intermittent Hypoxia During Hyperoxia in a Rat Model for Oxygen-Induced Retinopathy. Kay D. Beharry1, C. L. Cai2, P. Sharma2, G. B. Valencia2, D. R. Lazzaro3, J. V. Aranda1. 1Pediatrics & Ophthalmology, State Univ of New York Downstate Med Ctr, Brooklyn, NY; 2Pediatrics/Neonatology, State Univ of New York Downstate Med Ctr, Brooklyn, NY; 3Ophthalmology, State Univ of New York Downstate Med Ctr, Brooklyn, NY 5569 — B0092 Insulin and Angiogenesis: Excessive Insulin Induces Over-Proliferation of Tunic Vasculosa Lentis in Mice. Huiyi Chen, D. P. Hainsworth, L. W. Reneker. Ophthalmology, University of Missouri-Columbia, Columbia, MO 5570 — B0093 Angiogenic profile of hypoxic vascular endothelial cells overexpressing RTEF1. Binoy Appukuttan1, A. J. Stempel1, B. Wilmot2, T. Stout1. 1Ophthalmology, Casey Eye Institute OHSU, Portland, OR; 2OCTRI, OHSU, Portland, OR *CR 5571 — B0094 Manipulating Pericyte Contractility Alters Endothelial Growth and Angiogenic Potential. Jennifer T. Durham, I. M. Herman. Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA *CR 5572 — B0095 Enhancing function of endothelial progenitors by targeting the transforming growth factor-β1/plasminogen activator inhibitor-1 system. Sergio Caballero1, S. Hazra1, V. Stepps3, A. D. Bhatwadekar1, M. E. Boulton2, R. N. Mames4, S. Bartelmez3, M. B. Grant1. 1Pharmacology/Therapeutics, University of Florida, Gainesville, FL; 2Anatomy and Cell Biology, University of Florida, Gainesville, FL; 3 BetaStem Therapeutics, Inc., San Franscisco, CA; 4 The Retina Center, Gainesville, FL *CR 5573 — B0096 Mechanisms of Hyperoxiainduced Retinal Endothelial Cell Death and Senescence. Orla M. Galvin, T. A. Gardiner, D. M. McDonald. Queen’s University Belfast, Belfast, United Kingdom 5574 — B0097 SOCS3 inhibits pathologic angiogenesis. Jean-Sebastien Joyal1, A. Stahl2, Y. Sun1, Z. Shao1, Z. Fu1, A. Juan1, D. T. Pei1, C. G. Hurst1, J. Chen1, L. E. Smith1. 1Ophthalmology, Children’s Hospital, Harvard Med Sch, Boston, MA; 2Ophthalmology, University Eye Hospital Freiburg, Freiburg, Germany 5575 — B0098 The Alternative Complement System Mediates Neovascularization in Retinopathy. John H. Sweigard, R. Yanai, K. M. Connor, P. Y. Gaissert, A. Thanos. Angiogenesis, Harvard Medical School/MEEI, dorchester, MA f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 355 Thursday Posters 8:30 am – 10:15 am 5559 — B0082 Knockout of IGFBP-3 in Mice Produces Changes Similar to Chronic Diabetes in the Retina. Jena J. Steinle1, 4, Y. Jiang1, Q. Zhang1, L. Liu4, B. Peng3, J. Pintar3, T. S. Kern2. 1 Ophthalmology, Univ of Tennessee Hlth Sci Ctr, Memphis, TN; 2Ophthalmology and Medicine, Case Western Reserve University, Cleveland, Oman; 3Neuroscience and Cell Biology, UMDNJRobert Wood Johnson Medical School, Piscataway, NJ; 4Anatomy and Cell Biology, University of Tennessee Health Science Center, Memphis, TN *CR 5560 — B0083 A potential role for cytochrome P450 epoxygenases and their epoxyeicosatrienoic acid products in oxygen-induced retinopathy. Megan E. Capozzi1, J. S. Penn1, 2. 1Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN; 2Department of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN *CR 5576 – 5596 – Thursday – Posters 5576 — B0099 Regulation of Retinal Angiogenesis by a Novel Lactate Receptor, GPR81. Ankush Madaan1, 2, D. Hamel2, J. Rivera2, S. Chemtob1, 2. 1Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada; 2CR Hospital Sainte Justine, Universite de Montreal, Montreal, QC, Canada 5577 — B0100 TEAD4 Isoform Inhibits Vessel Growth in an Aortic Ring Assay. Trevor J. McFarland, B. Appukuttan, T. Stout. Retina, Casey Eye Institute-OHSU, Portland, OR *CR 5578 — B0101 Human adipose stem cell derived pericytes protect against retinal vasculopathy in vivo. Thomas A. Mendel1, 2, E. B. Clabough2, 3, D. S. Kao2, T. N. Demidova-Rice4, 5, B. Zotter2, E. P. Rakoczy6, A. J. Katz7, 8, I. M. Herman4, S. M. Peirce9, P. A. Yates2. 1Pathology, University of Virginia, Charlottesville, VA; 2Ophthalmology, University of Virginia, Charlottesville, VA; 3 Biology, Randolph-Macon College, Ashland, VA; 4 Molecular Physiology and Pharmacology, Tufts University, Boston, MA; 5E.L. Steele Laboratory for Tumor Biology, Harvard Medical School, Boston, MA; 6Molecular Ophthalmology, The University of Western Australia, Nedlands, WA, Australia; 7Plastic Surgery, University of Virginia, Charlottesville, VA; 8 Plastic Surgery, University of Florida, Gainesville, FL; 9Biomedical Engineering, University of Virginia, Charlottesville, VA *CR 5579 — B0102 Regulating the Regulator: MicroRNA-dependent Control of the Proangiogenic Activity of the Matricellular Protein CCN1 in Ischemic Retinopathy. Lulu Yan, O. Szereszowiec, B. Chaqour. SUNY Downstate Medical Center, Brooklyn, NY Thursday Posters 8:30 am – 10:15 am 5580 — B0103 Role of Nrf2 in the regulation of retinal revascularization and pathologic angiogenesis in oxygen-induced retinopathy. Yanhong Wei1, J. Gong1, R. Thimmulappa2, S. Biswal2, E. J. Duh1. 1Ophthalmology, Johns Hopkins University, Baltimore, MD; 2Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD Exhibit Hall B0105-B0137 Thursday, May 09, 2013 8:30 AM-10:15 AM Retinal Cell Biology 510 Glia in Health and Disease Moderators: Erica L. Fletcher and Przemyslaw Sapieha 5582 — B0105 Gene Expression Changes in Aging Retinal Microglia: Relationship to Microglial Support Functions and Regulation of Microglial Activation. Wenxin Ma1, 4, R. Cojocaru2, 4 , N. Gotoh2, 4, L. Gieser2, 4, R. Villasmil3, 4, T. Cogliati2, 4, A. Swaroop2, 4, W. T. Wong1, 4. 1Unit on Neuron-Glia Interactions in Retinal Disease, NEI/NIH, Bethesda, MD; 2NeurobiologyNeurodegeneration and Repair Laboratory, NEI/ NIH, Bethesda, MD; 3Flow Cytometry Core Facility, NEI/NIH, Bethesda, MD; 4NEI/NIH, Bethesda, MD 5583 — B0106 Reactive microglia and the formation of Müller glia-derived retinal progenitors. Chris Zelinka, M. Scott, A. J. Fischer. Neuroscience, Ohio State University, Columbus, OH 5584 — B0107 Dicer Loss Leads to Müller Cell Gliosis in the Mouse Retina. Vijay P. Sarthy1, V. Dudley1, D. Dalkara2, D. V. Schaffer2, J. G. Flannery2. 1Ophthal-Feinberg Med Sch, Northwestern University, Chicago, IL; 2Chemical and Biomolecular Engineering, The Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 5585 — B0108 A Novel Glial Cell in the Human Retina. Ellen Miller1, C. Zelinka2, A. J. Fischer2, C. M. Cebulla1. 1Ophthalmology, Havener Eye Institute, The Ohio State University Wexner Medical Center, Columbus, OH; 2Neuroscience, The Ohio State University, Columbus, OH 5586 — B0109 The Time Course of Gene Expression during Reactive Gliosis in the Optic Nerve. Juan Qu, T. C. Jakobs. Ophthalmology, Massachusetts Eye & Ear Infirmary, Boston, MA 5587 — B0110 Retinal Astrocytes in the Mouse Model of Oxygen-Induced Retinopathy. Felicitas Bucher, A. Stahl, G. Martin, H. T. Agostini. University Eye Hospital Freiburg, Freiburg, Germany 5588 — B0111 Glia alterations in the retina of a multiple sclerosis animal model. Heiko Schmid1, L. Horstmann1, F. Kurschus2, A. Waisman2, B. H. Dick1, S. C. Joachim1. 1Experimental Eye Research Institute, Knappschaftskrankenhaus Bochum, Bochum, Germany; 2Institute for Molecular Medicine, University Medical Center of the Johannes Guntenberg University, Mainz, Germany *CR 5589 — B0112 Powerful Beneficial Effects of Macrophage Colony-stimulating Factor on Retinal Microglia Proliferation and Vascular Repair in the Mouse Model of Oxygen-Induced Retinopathy. Xiaoshuang Jiang, Y. Ni, G. Xu. Ophthalmology Department, Eye and ENT Hosp of Fudan University, Shanghai, China 5590 — B0113 Role of Translocator Protein (TSPO) in the Regulation of Microglial Function in the Mouse Retina. Minhua Wang1, L. Zhao1, W. Ma1, R. Fariss2, W. T. Wong1. 1Unit on Neuron-Glia Interations in Retinal Disease, National Institutes of Health, National Eye Institute, Bethesda, MD; 2 Biological Imaging Core, National Institutes of Health, National Eye Institute, Bethesda, MD 5591 — B0114 Microglial response to nanosecond laser application to the retinal pigment epithelium. Erica L. Fletcher1, S. A. Mills1, U. Greferath1, R. H. Guymer2, M. J. Plunkett3, A. I. Jobling1. 1Dept Anatomy/ Neuroscience, University of Melbourne, Parkville, VIC, Australia; 2Centre for Eye Research Australia, The University of Melbourne, Parkville, VIC, Australia; 3Ellex Pty Ltd, Adelaide, SA, Australia *CR 5592 — B0115 BMP7 Can Act as a Trigger of Reactive Gliosis in Muller Glia. Subramanian Dharmarajan1, N. Sheibani2, T. L. Belecky-Adams1. 1 Dept of Biology, IUPUI, Indianapolis, IN; 2 Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 5593 — B0116 Modulation of Müller glial-neuronal cell interactions attenuates photoreceptor damage in a novel transgenic model of conditional Müller cell ablation. Weiyong Shen, L. Zhu, S. Lee, S. H. Chung, M. C. Gillies. Clin Ophthal & Eye Health, University of Sydney, Sydney, NSW, Australia *CR 5594 — B0117 The change of retinal ganglion cells and expression of vascular endothelial growth factor in diabetic rat model. Chankee Park, J. Kim, H. L. Park. Catholic University of Korea, Seoul St. Mary’s hospital, Seoul, Republic of Korea 5595 — B0118 Functional Analysis of Cultured Astrocytes from the Murine Optic Nerve Head. Rumi Kawashima, K. Matsushita, S. Usui, K. Nishida. Osaka University Medical School, Suita, Japan *CR 5596 — B0119 Retinal glial changes in Alzheimer’s disease. Malia M. Edwards1, D. S. McLeod1, R. Gutierrez-Lanza2, J. J. Rodriguez Arellano2, 3, G. A. Lutty1. 1Wilmer Eye Institute, Baltimore, MD; 2Department of Neusosciences, University of the Basque Country UPV/EHU, Leioa, Spain; 3Department of Neuroscience, Ikerbasque, Bizkaia, Spain The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 356 Thursday – Posters – 5997 – 5616 5597 — B0120 Quantitative Profiling of RMG Cell Surface Proteome Changes in Response to LPS Treatment. Stefanie M. Hauck1, C. von Toerne1, M. Blindert1, J. Behler1, C. A. Deeg2, M. Ueffing3, 1. 1Department of Protein Science, Helmholtz Center Munich, Neuherberg, Germany; 2 Institute of Animal Physiology, Department for Veterinary Sciences, Faculty of Veterinary Medicine, LMU Munich, Munich, Germany; 3 Centre of Ophthalmology, University Medical Centre, Tübingen, Germany 5598 — B0121 Anti-VEGF therapy inhibits microglial activation and migration in the retina. Aude Couturier1, 2, E. Bousquet2, M. Zhao2, B. Goldenberg2, Y. De Kozak2, F. F. Behar-Cohen2, 3. 1 ophthalmology, Hopital Lariboisière, Université Paris Diderot-Sorbonne Paris Cité, APHP, Paris, France; 2UMRS 872 Physiopathology of Ocular Diseases: Therapeutic Innovations, INSERM, Paris, France; 3Ophthalmology, Hopital Hotel Dieu, Université Paris Descartes, APHP, Paris, France *CR 5599 — B0122 The Role of Endoglin in Retinal Neovascularization. Sandra Suarez2, J. M. Barnett3, J. S. Penn1, 2. 1Ophthalmology and Visual Sciences, Vanderbilt Univ Medical Center, Nashville, TN; 2Cell and Developmental Biology, Vanderbilt University, Nashville, TN; 3 Pharmacology, Vanderbilt University, Nashville, TN *CR 5600 — B0123 Investigation of Iba1+/NG2+ cells In the Adult Mouse Retina after IschemiaReperfusion Injury with or without Lycium barbarum polysaccharide treatment. Qian Feng1, S. Chung1, K. So1, 2. 1Department of Anatomy, The University of Hong Kong, Hong Kong, Hong Kong; 2 Laboratory of Neurodegenerative Diseases, The University of Hong Kong, Hong Kong, Hong Kong 5601 — B0124 Vitreous Levels of Soluble Vascular Adhesion Protein-1 and Prorenin in Proliferative Diabetic Retinopathy. Saori Takashina1, 2, K. Noda1, 2, S. Namba1, 2, R. Ando1, 2, M. Murata1, 2, C. Yoshizawa2, W. Saito2, A. Kanda1, 2, S. Ishida1, 2. 1Laboratory of Ocular Cell Biology and Visual Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 2Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan 5603 — B0126 The involvement of apolipoprotein E on intraocular angiogenesis. Yuhei Hashimoto, S. Nakamura, H. Takizawa, K. Tsuruma, M. Shimazawa, H. Hara. Gifu Pharmaceutical University, Gifu, Japan 5606 — B0129 Knocking Down p75NTR Expression Prevents Retinal Acellular Capillary Formation In ProNGF-Overexpression Model. Ahmed Shanab1, 2, B. A. Mysona1, 2, S. Matragoon1, 3, A. B. El-Remessy1, 2. 1Clinical and Experimental Therapeutic, University of Georgia, Augusta, GA; 2 Vision Discovery Institute, Georgia Health Science University, Augusta, GA; 3VA Medical Center, Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 5607 — B0130 Angiogenic potency of endogenous calcitonin gene-related peptide (CGRP) in mouse model of oxygen-induced retinopathy. Yuichi Toriyama1, 2, Y. Iesato1, 2, T. Sakurai2, A. Kamiyoshi2, Y. IchikawaShindo1, 2, T. Shindo2, T. Murata1. 1Department of Ophthalmology, Shinshu University Graduate School of Medicine, Matsumoto,Nagano, Japan; 2 Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto,Nagano, Japan 5608 — B0131 Involvement of netrin-4 in oxygen induced neovascularisation. Sabrina V. Klein1, A. B. Maier1, Y. Liang2, N. Kociok1, M. Koch3, W. J. Brunken4, O. Strauss1, A. M. Joussen1. 1 Ophthalmology, Charite Universitätsmedizin Berlin, Berlin, Germany; 2Ophthalmology, Peking University, Beijing, China; 3Institute for Biochemistry II, University of Cologne, Cologne, Germany; 4Department of Ophthalmology and Cell Biology, SUNY Downstate Medical Center, New York, NY 5609 — B0132 Annexin V inhibits pathological retinal angiogenesis but not physiological retinal vascular development. Satoshi Morooka1, T. Murakami1, M. Nukada1, 2, N. Yoshimura1. 1 Ophthalmology and Visual Sciences, Kyoto University, Kyoto, Japan; 2Shiga Medical Center for Adults, Shiga, Japan *CR 5610 — B0133 Loss of Caveolin-1 Results in Blood-Retinal Barrier Permeability, Venous Enlargement and Mural Cell Alteration. Xiaowu Gu1, 2, S. J. Fliesler3, 4, M. H. Elliott1, 2. 1Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK; 2 Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK; 3Departments of Ophthalmology and Biochemistry, SUNY/Buffalo & SUNY Eye Institute, Buffalo, NY; 4Research Service, VAWNYHS, Buffalo, NY 5611 — B0134 Systemic Inflammatory Stress Provokes Abnormal Retinal Vascular Development. Sophie Tremblay1, S. Favret1, F. Binet1, S. Chaychi2, A. Polosa2, P. Lachapelle2, S. Chemtob3, P. Sapieha1. 1Vision Health, HMR Research Center, Montreal, QC, Canada; 2 Ophtalmology Department, McGill UniversityChildren’s Hospital, Montreal, QC, Canada; 3FoetoMaternal Pathologies, CHU Ste-Justine Research Center, Montreal, QC, Canada 5612 — B0135 Elucidating molecular mechanisms of blood retina barrier permeability. Daniel L. Chao1, E. Salero1, Y. Wang1, C. Volmar2, J. L. Goldberg1. 1Ophthalmology, Bascom Palmer Eye Inst, Univ of Miami, Coral Gables, FL; 2Psychiatry, University of Miami, Miami, FL 5613 — B0136 EphA2 Stimulation of Angiogenesis is Dependent on VEGFR2. Luciana Ferrara, A. De Erkenez, E. Fassbender, S. Shen, A. Woolfenden, Y. Qiu, S. H. Poor, K. Anderson, B. D. Jaffee. Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA *CR 5614 — B0137 Blockade of transient receptor potential (TRP) channels inhibits retinal neovascularization via inhibition of calcium ion dependent signaling pathway. Hyun Beom Song1, 2, H. Jun1, J. Kim1, I. Jo3, J. Kim2, 4. 1Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; 2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea; 3Department of Molecular Medicine and Ewha Medical Research Institute, Ewha Womans University Medical School, Seoul, Republic of Korea; 4Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea Exhibit Hall C0001-C0049 Thursday, May 09, 2013 8:30 AM-10:15 AM Glaucoma 511 Intraocular Pressure Moderator: Arthur J. Sit 5615 — C0001 Postural change in intraocular pressure between sitting and lying body positions - a direct comparison of its measurement with an unmodified Goldmann applanation tonometer, Tonopen XL, pneumatonometer, and HA-2 hand-held applanation tonometer. Yaniv Barkana. 1 Ophthalmology, Assaf Harofe Medical Center, Beer Yaakov, Israel; 2Ophthalmology, Tel Aviv University, Tel Aviv, Israel *CR 5616 — C0002 A new Tonometer-the Corvis ST Tonometer Clinical Comparison with Non-contact, and Goldmann Applanation Tonometers. Jiaxu Hong, J. Xu, A. Wei, S. X. Deng, X. Sun. Ophthalmology, Eye & Ear, Nose, Throat Hospital, Shanghai, China 5604 — B0127 Increased expression of Adenosine A2B receptor in endothelial precursor cells contributes to diabetes-induced dysfunction. Rehae C. Miller, M. B. Grant. Pharmacology and Therapeutics, University of Florida, Gainesville, FL f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 357 Thursday Posters 8:30 am – 10:15 am 5602 — B0125 Are hypoxia and succinate mediators of renin-angiotensin system related vascular injury in the retina? Roksana Armani, A. Agrotis, J. L. Wilkinson-Berka. Immunology, Monash University, Melbroune, VIC, Australia *CR 5605 — B0128 Role of Sp1 transcription factor in the pathogenesis of diabetic retinopathy. Kelly Donovan, O. Alekseev, J. Azizkhan-Clifford. Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 5617 – 5640 – Thursday – Posters 5617 — C0003 Intraocular pressure characteristics of subjects with either exfoliation syndrome or exfoliative glaucoma as determined with the Water Drinking Test: preliminary findings. Mehmet C. Mocan1, B. Kasım1, E. Muz1, M. Orhan1, M. T. Irkec1, D. G. Mikropoulos2, A. P. Konstas2. 1Department of Ophthalmology, Hacettepe Univ School of Medicine, Ankara, Turkey; 21st Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece *CR 5618 — C0004 Investigation of the Effect of Gonioscopy on Intraocular Pressure. Ardalan Aminlari, C. Callahan, I. U. Scott, G. C. Papachristou, J. Olson. Ophthalmology, Penn State Hershey Eye Center, Hershey, PA 5619 — C0005 Diurnal Non-Clinic-Measured Intraocular Pressure Profile in Primary AngleClosure Glaucoma Patients. Shaoying Tan, N. B. Baig, C. C. Tham. Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong *CR 5620 — C0006 The Effect of Child Delivery Process on the Intraocular Pressure in Healthy Women. Amit Meshi1, S. Armarnik1, H. Kaneti2, F. Segev1, E. I. Assia1, 3, N. Geffen1. 1Ophthalmology, Meir Medical Center, Kfar-Saba, Israel; 2Obstetrics and Gynecology, Meir Medical Center, Kfar-Saba, Israel; 3Ein-Tal, Tel Aviv, Israel *CR, f 5621 — C0007 Association of Epidural Steroid Injections(s) with Intraocular Pressure Elevation. Deepti Saini1, I. U. Scott1, C. Callahan1, J. Malayil2, J. Gillon1, J. Eckert2. 1Ophthalmology, Penn State Milton S. Hershey Medical Center, Hershey, PA; 2Pain Management, Penn State Milton S. Hershey Medical Center, Hershey, PA 5622 — C0008 Relationship between Central Corneal Thickness and Intraocular Pressure in Indigenous Africans in Nigeria. Nwamalubia N. Nzelu- Egwuonwu. 1Ophthalmology, Mass Medical Mission, Lagos, Nigeria; 2Ophthalmology, Mass Medical Mission, Lagos, Nigeria Thursday Posters 8:30 am – 10:15 am 5623 — C0009 Refined IOP measurement with rebound tonometry in the rabbit. Hong Zhang1, 2, D. Yang1, 3, C. Ross1, J. P. Wigg1, S. S. Pandav1. 1 Ophthalmology, Ctr for Eye Resrch Australia, East Melbourne, VIC, Australia; 2Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia; 3 Harbin Medical University, Harbin, China 5624 — C0010 IOP measurement with I-CARE Rebound Tonometer, Pneumotonometer and Tonopen in Sedated Children with Glaucoma and Controls. Fatemah T. Al-Shamlan1, J. Song1, 2, D. P. Edward1, 2, I. Al Jadaan1, S. A. Al Shahwan1, J. Morales1, A. O. Khan1, S. Al-Mesfer1, A. H. Awad1, S. Al Turkmani1. 1King Khalid Eye Specialist Hospital, Riyadh, Saudi Arabia; 2Ophthalmology, Wilmer Eye Institute/Johns Hopkns University, Baltimore, MD f 5626 — C0012 24-Hour Intraocular Pressure Rhythm in Young Healthy Subjects Evaluated With Continuous Monitoring Using Contact Lens Sensor. Christophe Chiquet1, 2, B. Mottet1, 2, F. Aptel1, 2, R. Hubanova1, J. Pépin2, J. Romanet1. 1 Department of Ophthalmology, University Hospital, CHU Grenoble, Grenoble, France; 2Lab Hypoxia and Physiopathology, INSERM U1042, Joseph Fourier University, Grenoble, France *CR 5627 — C0013 Randomized Clinical Investigation to Assess the Efficacy of SENSIMED Triggerfish® Continuous IOP Monitoring. Milko E. Iliev1, J. Thygesen2, E. Vandewalle3, J. Garcia-Feijoo4, S. GarciaDelpech5. 1Ophthalmology, University of Bern, Bern, Switzerland; 2Ophthalmology, Copenhagen University Hospital, Glostrup, Denmark; 3 Ophthalmology, University Hospitals Leuven, Leuven, Belgium; 4Ophthalmology, Instituto de Investigación Sanitaria HCSC, Universidad Complutense, Madrid, Spain; 5Ophthalmology, Hospital Universitario y Politécnico la Fe, Valencia, Spain *CR, f 5628 — C0014 Single versus Multiple Measurements for Comparing Group Intraocular Pressure. Brian Chon1, 2, G. Smits3, S. C. Lin2, S. Ianchulev2, 3. 1School of Medicine, Duke University, Durham, NC; 2Department of Ophthalmology, University of California San Francisco, San Francisco, CA; 3Transcend Medical, Menlo Park, CA *CR, f 5629 — C0015 Ocular Hypertension Profile after Pterygium Excision. Maria Husain, A. Nguyen, K. Nagi. Ophthalmology, University of Texas Health Science Center, San Antonio, TX 5630 — C0016 IOP lowing effect of prostanoid FP and EP3 receptor dual agonist on mouse eyes. Reiko Yamagishi1, K. Nagai3, S. Yamane3, M. Aihara2, 1. 1Dept of Ophthalmology Sch of Med, University of Tokyo, Bunkyo-ku, Japan; 2Shirato eye clinic, Tokyo, Japan; 3Ono Pharmaceutical Co., LTD., Osaka, Japan *CR 5631 — C0017 Sub-chronic IOP lowering effect of AMA0076 and Y-39983 in Dutch Belted rabbits. Sarah Van de Velde1, T. Van Bergen1, D. Sijnave1, K. P. Hollanders1, E. Vandewalle1, L. K. Moons2, D. Leysen3, I. Stalmans1. 1Lab of Ophthalmology, KULeuven, Leuven, Belgium; 2 Biology, Zoölogical Institute, KULeuven, Leuven, Belgium; 3Amakem Therapeutics, Diepenbeek, Belgium *CR 5632 — C0018 Altered expression of TGFβ1 and MMP-9 results in elevated intraocular pressure in mice. Anuja Siwakoti1, J. Robertson2, J. A. West-Mays2. 1Medical Sciences, Mcmaster University, Hamilton, ON, Canada; 2Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada 5633 — C0019 Sustained Delivery of Travoprost from a Biodegradable Hydrogel Punctum Plug for the Treatment of Glaucoma. Abbe Miller, C. D. Blizzard, A. S. Sawhney, M. Bassett, P. Jarrett, A. Driscoll, M. O’Connor, D. Molla, S. Takach. Ocular Therapeutix, Inc., Bedford, MA *CR 5634 — C0020 Assessment of Intervisit IOP Control in Eyes with Advanced Glaucoma. Priya Patel, N. Pritz, R. D. Fechtner, A. S. Khouri. New Jersey Medical School, Newark, NJ 5635 — C0021 Short duration intraocular pressure patterns detected by a contact lens sensor for 24-hour recording. Kaweh Mansouri1, 2, R. N. Weinreb2, R. Goedkoop3, M. Moshtaghi2, S. Dorairaj4, 2, A. Tafreshi2, J. H. Liu2. 1Glaucoma sector, Division of Ophthalmology, University of Geneva, Geneva, Switzerland; 2Department of Ophthalmology, Hamilton Glaucoma Center, University of California, San Diego, La Jolla, CA; 3 Sensimed AG, Lausanne, Switzerland; 4Department of Ophthalmology, Mayo clinic, Jacksonville, FL *CR, f 5636 — C0022 Intraocular pressure after phacoemulsification in glaucoma patients. Karine D. Bojikian1, 2, M. A. Slabaugh1, P. P. Chen1. 1 Ophthalmology, University of Washington, Seattle, WA; 2Ophthalmology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil *CR 5637 — C0023 24-hour intraocular pressure (IOP) fluctuation profile before and after laser peripheral iridotomy in newly diagnosed subjects with primary angle closure. Baskaran Mani1, 2, T. Aung1, 2. 1Singapore Eye Research Institute, Singapore, Singapore; 2Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore *CR 5638 — C0024 Effects of Different Sleeping Postures on Intraocular Pressure and Ocular Perfusion Pressure in Healthy Young Subjects. Chungkwon Yoo, T. Lee, Y. Y. Kim. Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea 5639 — C0025 Intraocular pressure and central corneal thickness in 91,000 patients. Shilpa Desai1, J. Schallhorn1, S. C. Schallhorn2, Y. Ou1. 1Ophthalmology, USCF, San Francisco, CA; 2 Optical Express, San Diego, CA *CR 5640 — C0026 Spectral analysis of intraocular pressure pulse wave for early prediction of glaucoma. Magdalena Widlicka1, D. Iskander2, P. Krzyzanowska-Berkowska3, M. A. Kowalska1. 1 Institute of Physics, Wroclaw University of Technology, Wroclaw, Poland; 2Institute of Biomedical Engineering and Instrumentation, Wroclaw University of Technology, Wroclaw, Poland; 3Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland *CR 5625 — C0011 Twenty-Four-Hour Habitual Intraocular Pressure in Young, Myopic, Untreated Open- Angle Glaucoma Patients. Jeong D. Dawoon, K. S. Michael, L. Kyong Sub, L. Jong Rak. Ophthalmolgy, Asan Medical Center, Seoul, Republic of Korea The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 358 Thursday – Posters – 5641 – 5662 5641 — C0027 Intraocular pressure measured by tonometry and a contact lens sensor in patients with open angle glaucoma. Katrin Lorenz1, R. Goedkoop2, M. M. Keilani1, N. Berssenbruegge1, C. A. Korb1, J. WasielicaPoslednik1, N. Pfeiffer1. 1Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany; 2Sensimed AG, Lausanne, Switzerland *CR, f 5642 — C0028 Characterization of Vav2/3deficient mice with spontaneous IOP elevation. Keiko Fujikawa1, K. Inoue1, T. Koshiyama2, R. Yamagishi3, M. Aihara3, 4. 1Hokkaido University Graduate School of Health Science, Sapporo, Japan; 2 Hokkaido University Graduate School of Medicine, Sapporo, Japan; 3University of Tokyo Graduate School of Medicine, Tokyo, Japan; 4Shirato Eye Clinic, Tokyo, Japan *CR 5649 — C0035 Establishment of the ocular hypertension model using the common marmoset. Masamitsu Shimazawa1, S. Nakamura1, M. Miwa2, K. Tsuruma1, M. Aihara3, K. Nakamura2, H. Hara1. 1Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan; 2Department of Behavioral and Brain Sciences, Primate Research Institute, Kyoto University, Inuyama, Japan; 3Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan *CR 5650 — C0036 Intraocular pressure in chronic users of low-dose oral corticosteroids for connective tissue disease. Beatriz Gomes1, 2, M. R. Santhiago1, H. Moraes1. 1Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 2Bonsucesso Federal Hospital, Rio de Janeiro, Brazil 5643 — C0029 First implantation of a telemetric, intraocular pressure sensor in patients with glaucoma. Niklas Plange, A. Koutsonas, P. Walter. Dept of Ophthalmology, RWTH Aachen University, Aachen, Germany *CR, f 5651 — C0037 Changes in intraocular pressure measurements and corneal biomechanical properties in eyes with glaucoma using prostaglandin analogues. Maria Jose Montero, O. D. Albis-Donado, J. Jimenez-Roman. Glaucoma, APEC, mexico city, Mexico 5644 — C0030 Comparison of Rebound Tonometer Icare-Pro and Goldmann Handheld Applanation Tonometer in Congenital Glaucoma. Laura Morales-Fernandez, L. Borrego, J. M. Martinez de la Casa, F. Saenz-Frances, J. Garcia-Feijoo. Glaucoma, Hospital Clinico, Madrid, Spain *CR 5652 — C0038 Effect on intraocular pressure after intravitreal injection of anti-vascular endothelial growth factor agents in eyes with neovascular age related macular degeneration. Junglim Kim1, J. Lee2. 1busan paik hospital, Busan, Republic of Korea; 2Yonseiplus eye center, seoul, Republic of Korea 5645 — C0031 The Effect of the Automated Visual Field Examination on Intraocular Pressure (IOP) in Patients with Glaucoma. Sonya Makhni1, D. Dave1, M. Karl2, J. B. Serle1. 1Mount Sinai School of Medicine, New York, NY; 2SUNY Downstate College of Medicine, Brooklyn, NY *CR 5653 — C0039 Intraocular Pressure Changes by Continous Recording Through Triggerfish Contact Lens Application in Patients Undergoing Water Drinking Test: Correlation with Goldmann Readings in Controlateral Eye. Nicola Ungaro1, G. Scazzi1, M. Giacosa1, M. Tardini2, G. Bacchi1, S. A. Gandolfi2. 1Azienda Ospedaliera Universitaria di Parma, Parma, Italy; 2Università degli studi di Parma, Parma, Italy *CR 5646 — C0032 Ocular Indications of Partial Penetrance in Mice Heterozygous for NBCe1 (Slc4a4). Michael F. Romero1, 2, H. L. Holmes1, U. Roy Chowdhury3, C. R. Hann3, M. Chang1, M. P. Fautsch3, A. Chen1. 1Physiology & Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN; 2Nephrology & Hypertension, Mayo Clinic College of Medicine, Rochester, MN; 3 Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 5648 — C0034 The Role Of Ageing In Experimental Glaucoma. T. H. Khanh Vu1, 2, K. Cho1, M. M. Jager2, D. F. Chen1. 1Ophthalmology, Schepens Eye Research Institute, Boston, MA; 2 Ophthalmology, Leiden University Medical Center, Leiden, Netherlands *CR 5655 — C0041 Are thinner corneas associated with reduced hystersis? Trupti Patil, R. Sasikumar, S. A. Devi. Glaucoma, Narayana Nethralaya, Banglore, India 5656 — C0042 Continuous intraocular pressure monitoring with a wireless contact lens and ocular telemetry sensor in patients with open angle glaucoma: pilot study. Claudia Cortes Alcocer1, 2, J. Jimenez-Roman1, F. Gil Carrasco1, F. Del Real2. 1Glaucoma, APEC, Mexico City, Mexico; 2 Universidad La Salle, Mexico City, Mexico 5658 — C0044 24-hour IOP monitoring with the SENSIMED Triggerfish contact lens: effect of sleep position and assessment of upward drift. Laura Beltran-Agullo1, J. Cheng1, Y. M. Buys1, 2, F. Jahan3, J. G. Flanagan1, 2, C. M. Shapiro3, 1 , N. Hossain3, S. Simon-Zoula4, G. E. Trope1, 2. 1 Ophthalmology, Toronto Western Hospital, Toronto, ON, Canada; 2University of Toronto, Toronto, ON, Canada; 3Sleep Research Unit, Toronto Western Hopsital, Toronto, ON, Canada; 4 Sensimed AG, Lausanne, Switzerland *CR, f 5659 — C0045 The Effect of Intravitreal Kenolog on Intraocular Pressure in Patients with Glaucoma. Melanie McQueen, J. Tannir, R. Momi, B. A. Hughes, A. Goyal, M. S. Juzych, C. Kim, A. M. Eby, F. Fatima, M. H. Peracha. Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI 5660 — C0046 Comparative Agreement Among Three Methods of Tonometry: Goldmann Applanation, Transpalpebral, and Dynamic Contour. Luis A. Zarate1, M. García-Huerta1, R. Castañeda1, M. Turati1, F. Gil Carrasco1, J. Jimenez-Roman1, J. A. Paczka2. 1Glaucoma, Asociacion Para Evitar la Ceguera en Mexico, Mexico, Mexico; 2Glaucoma, 3. Asistencia e Investigacion en Glaucoma, A.C, Guadalajara, Mexico 5661 — C0047 Hemofiltration impact on intraocular pressure in patients with end stage renal disease without any evidence of glaucoma. Ruth Georgina Navarrete Ortega1, R. Navarrete Ortega1, H. Perez Grovas1, 2. 1Glaucoma, Hospital Nuestra Señora De La Luz, México, City, Mexico; 2 Nefrology, Instituto Nacional De Cardiologia “Ignacio Chavez”, México, City, Mexico f 5662 — C0048 Central Corneal Thickness and IOP Response to Topical Ocular Hypotensive Medication in the Low-pressure Glaucoma Treatment Study. Christopher C. Teng1, 2, G. De Moraes1, 2, J. M. Liebmann2, D. S. Greenfield3, R. Ritch1, 4, T. Krupin5, 6. 1Ophthalmology, Einhorn Clinical Research Center, New York Eye & Ear Infirmary, New York, NY; 2Ophthalmology, NYU School of Medicine, New York, NY; 3 Ophthalmology, Bascom Palmer Eye Institute, Palm Beach Gardens, FL; 4Ophthalmology, New York Medical College, Valhalla, NY; 5 Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL; 6The Chicago Center for Vision Research, Chicago, IL *CR, f f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 359 Thursday Posters 8:30 am – 10:15 am 5647 — C0033 Microbead Occlusion Model of Glaucoma in Non-Human Primates. Wendi S. Lambert, B. J. Carlson, D. J. Calkins. Vanderbilt Eye Institute, Vanderbilt University Med Center, Nashville, TN *CR 5654 — C0040 Comparison of the Cellular Response to Overnight Contact Lens Wear on the Sclera and Cornea. John G. Flanagan1, 2, A. D. Stavropoulos1, 5, D. Luensmann2, 3, C. K. Postnikoff4, M. Gorbet4, 3. 1Dept of Ophthal & Vision Sci, Univ of Toronto,Toronto Western Hosp, Toronto, ON, Canada; 2School of Optometry and Vision Science, Univeristy of Waterloo, Waterloo, ON, Canada; 3 Centre for Contact Lens Research, Univeristy of Waterloo, Waterloo, ON, Canada; 4Systems Design Engineering, Univeristy of Waterloo, Waterloo, ON, Canada; 5Institute of Medical Sciences, Univeristy of Toronto, Toronto, ON, Canada *CR 5657 — C0043 Development of an implantable system for measuring intraocular pressure in rats. Christopher L. Passaglia1, S. Bello2, R. T. Tzekov3, 4, S. S. Malavade3. 1Chemical and Biomedical Engineering, University of South Florida, Tampa, FL; 2Electrical Engineering, University of South Florida, Tampa, FL; 3 Ophthalmology, University of South Florida, Tampa, FL; 4Roskamp Institute, Sarasota, FL *CR 5663 – 5685 – Thursday – Posters 5663 — C0049 Comparison of Intraocular Pressure Measurements Using a Tono-Pen with Ocufilm + Cover Versus Examination Glove Fingertip Cover. Daniel Apple, B. Markowitz. Ophthalmology, University of South Carolina School of Medicine, Columbia, SC 5670 — C0141 Inter-ocular Difference of Axial Lengths in Children with Unilateral Congenital and Developmental Cataracts. Kathryn M. Haider, J. Wang, D. C. Mitchell, H. A. Smith, H. A. Smith, G. Roberts, D. Sprunger, D. E. Neely, D. Plager. Ophthalmology, Indiana University, Indianapolis, IN *CR 5677 — C0148 A comparison of non-cycloplegic and cycloplegic autorefraction using Spot™ (PediaVision LLC, Pompano Beach, FL) to manual cycloplegic retinoscopy in a pediatric population. Adil Bhatti, R. Abo-Shasha, R. Munger, M. O’Connor. Ophthalmology, University of Ottawa, Ottawa, ON, Canada Exhibit Hall C0135-C0163 5671 — C0142 Ophthalmic abnormalities in children with Developmental Coordination Disorder: Data from the Avon Longitudinal Study of Parents and Children. Alex Creavin1, 2, R. Lingam1, K. Northstone1, C. Williams1. 1School of social and community medicine, Bristol University, Bristol, United Kingdom; 2Ophthalmology, Cheltenham general hospital, Cheltenham, United Kingdom 5678 — C0149 Statistical evaluation in pediatric patients of Lang I stereo-test for the diagnosis of microesotropia in daily practice. Davide Allegrini1, M. Spera2, L. M. Rossetti1, L. Ottobelli1, A. C. Piantanida2. 1Eye Clinic, San Paolo Hospital, Milano, Italy; 2Eye Center, C.O.L. Centro Oculistico Lariano, Cernobbio (Como), Italy Thursday, May 09, 2013 8:30 AM-10:15 AM Clinical/Epidemiologic Research 512 Pediatric Epidemiology Moderators: Marjean T. Kulp and Mark A. Bullimore 5664 — C0135 The Prevalence of Infantile Esotropia in Children of Chinese Descent. Maria del Pilar Gonzalez Diaz, A. M. Wong. Ophthalmology and Visual Sciences, University of Toronto - The Hospital for Sick Children, Toronto, ON, ON, Canada 5665 — C0136 Chronic anterior uveitis in paediatric patients. Cristobal A. Couto, M. Frick, B. A. Schlaen, E. Hurtado Jallaza, M. Lopez. Ophthalmology, University of Buenos Aires, Buenos Aires, Argentina Thursday Posters 8:30 am – 10:15 am 5666 — C0137 Pediatric Idiopathic Orbital Inflammation. Jordan Spindle1, M. Pellegrini2, T. R. Shepler3, B. Esmaeli4, E. Wladis5, E. Piozzi6, C. L. Shields2, R. Shinder1, 4. 1Ophthalmology, SUNY Downstate Ophthalmology, Brooklyn, NY; 2Ocular Oncology, Wills Eye Institute, Philadelphia, PA; 3 Texas Oculoplastic Consultants, Austin, TX; 4 University of Texas MD Anderson Cancer Center, Houston, TX; 5Opthalmology, Albany Medical College, Albany, NY; 6A. O. Ospedale Niguarda Ca’ Granda, Milan, Italy 5667 — C0138 Risk Factors for Amblyopia in the Vision in Preschoolers (VIP) Study. Maisie R. Pascual1, J. Huang2, M. G. Maguire2, M. T. Kulp3, G. E. Quinn4, E. Ciner5, L. A. Cyert6, D. A. OrelBixler7, B. Moore8, G. Ying2. 1Drexel University College of Medicine, Philadelphia, PA; 2University of Pennsylvania, Philadelphia, PA; 3Ohio State University, Columbus, OH; 4Children’s Hospital of Philadelphia, Philadelphia, PA; 5Salus University, Elkins Park, PA; 6Northeastern State University, Tahlequah, OK; 7University of California, Berkeley, Berkeley, CA; 8New England College of Optometry, Boston, MA *CR 5668 — C0139 Refractive error and amblyopia in a school-children population of Central Italy. Paolo Trabucco1, M. Salomone1, I. Domanico1, E. gerace2, C. Carnevale2, E. M. Vingolo1. 1 Ophthalmology, Univ of Rome La Sapienza Osp “S M Goretti” LT, Latina, Italy; 2Ophthalmology, Univ of Rome La Sapienza, Rome, Italy 5669 — C0140 Efficacy and Safety of Ahmed Glaucoma Valve Implantation for Pediatric Glaucoma. Maria E. Lim, D. E. Neely, K. M. Haider, D. Plager. Indiana University School of Medicine, Indianapolis, IN 5672 — C0143 IOLunder2 study: outcomes following surgery with and without primary intraocular lens implantation in children <2years old. Lola A. Solebo1, 2, I. Russell-Eggitt2, 3, J. S. Rahi2, 4. 1MRC Centre Epidemiology (Child Health), Institute Child Health, UCL, London, United Kingdom; 2Ulverscroft Vision Research Group, London, United Kingdom; 3Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital, London, United Kingdom; 4Institute of Ophthalmology, UCL, London, United Kingdom 5673 — C0144 Clinical testing of a new objective binocular refraction device. Lei Shi1, Y. Chen1, J. W. Lewis2, M. X. Wang3. 1Center for Laser Applications, University of Tennessee Space Inst, Tullahoma, TN; 2E-Vision Technologies, Tullahoma, TN; 3Wang Vision Institute, Nashville, TN *CR 5674 — C0145 Ophthalmological long-term follow-up in children and young adults with Kearns-Sayre Syndrome. Marita A. Gronlund1, A. K. Seyedi Honarvar1, N. Darin2, M. Tulinius2, S. Andersson1. 1Pediatric Ophthalmology, Inst Neurosci & Phys/Ophthal, Goteborg, Sweden; 2 Dept of Peadiatrics, The Queen Silvia Children’s Hospital, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden 5675 — C0146 How should we assess reliability of visual field assessment in children? Dipesh Patel1, 3, P. Cumberland1, 2, I. Russell-Eggitt4, 2, B. Walters4, 2, J. S. Rahi1, 5. 1MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, United Kingdom; 2 Ulverscroft Vision Research Group, London, United Kingdom; 3Moorfields Eye Hospital, London, United Kingdom; 4Great Ormond Street Hospital, London, United Kingdom; 5UCL Institute of Ophthalmology, London, United Kingdom 5676 — C0147 Intraocular Pressure and Traumatic Hyphema in Children. Jeffrey SooHoo1, E. A. McCourt1, 2. 1Ophthalmology, University of Colorado Denver, Aurora, CO; 2 Ophthalmology, Children’s Hospital Colorado, Aurora, CO 5679 — C0150 Demographic Trends in Pediatric Cataract Surgery at a Tertiary Referral Center. Monica L. Bratton1, A. Lam2, D. Weakley1, S. Wang1. 1Department of Ophthalmology, University of Texas Southwestern, Dallas, TX; 2 University of Texas Southwestern Medical School, Dallas, TX 5680 — C0151 Relation between grade and gender and reasons for spectacle non-compliance among school aged children. Mabel Crescioni1, J. D. Twelker1, 2, J. M. Miller1, 2, T. K. Green1, I. Campus1, E. M. Harvey1, 2. 1Ophthalmology and Vision Science, University of Arizona, Tucson, AZ; 2 Public Health, University of Arizona, Tucson, AZ 5681 — C0152 Pilot testing of a multifunctional device for pediatric vision screening application. Ying-Ling Chen1, L. Shi1, J. W. Lewis2, M. X. Wang3. 1Center for Laser Applications, Univ of Tennessee Space Inst, Tullahoma, TN; 2E-Vision Technologies, Inc, Tullahoma, TN; 3Wang Vision Institute, Nashville, TN *CR 5682 — C0153 Ophthalmologic correlates of disease severity in Wolfram Syndrome. Smith Ann Chisholm1, 2, J. Hoekel2, T. Hershey3, 4, L. Tychsen1, 2. 1Ophthalmology, Washington University in St. Louis, Saint Louis, MO; 2Ophthalmology, Saint Louis Children’s Hospital, Saint Louis, MO; 3Neurology, Washington University in St. Louis, Saint Louis, MO; 4Radiology, Washington University in St. Louis, Saint Louis, MO 5683 — C0154 Detecting Tumor Progression in Optic Pathway Glioma. John P. Kelly, A. H. Weiss. Ophthalmology W-4743, Seattle Children’s Hospital, Seattle, WA 5684 — C0155 Down Syndrome and Accommodation: The Added Advantage of Bifocals. Brinda Muthusamy, R. Adyanthaya, S. Isenor, K. Irsch, K. Klein, D. L. Guyton. Pediatric Ophthalmology & Adult Strabismus, The Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD *CR 5685 — C0156 Retrospective Review of Refractive Error in Two Age Groups of Hispanic and African American Children Seen in a Chicago Vision Clinic. Sandra S. Block, M. A. Suckow, K. O’Leary, V. Conrad. School-Based Vision Clinic, Illinois College of Optometry, Chicago, IL The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 360 Thursday – Posters – 5686 – 5705 5686 — C0157 Development and validation of a novel functional vision instrument for children and young people with visual impairment. Val Tadic1, A. Cooper2, G. Lewando Hundt3, J. S. Rahi1, 4. 1MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, United Kingdom; 2Psychology Department, Goldsmiths, University of London, London, United Kingdom; 3School of Health and Social Studies, University of Warwick, London, United Kingdom; 4 UCL Institute of Ophthalmology, London, United Kingdom 5687 — C0158 A novel measure of visual function and vision related quality of life for childhood uveitis. Sheila Angeles-Han1, 2, S. Yeh1, 3, C. McCracken1, L. Vogler1, 2, K. Rouster-Stevens1, 2, C. Kennedy2, S. R. Lambert1, 3, K. Jenkins2, S. Prahalad1, 2, C. Drews-Botsch4. 1Pediatrics, Emory University, Atlanta, GA; 2Children’s Healthcare of Atlanta, Atlanta, GA; 3Ophthalmology, Emory University, Atlanta, GA; 4Rollins School of Public Health, Emory University, Atlanta, GA *CR 5688 — C0159 Effects of Lighting on Test Performance on the Odom-Robin Visual Efficiency Near Vision Chart in a School Aged Population. Robin B. Mumford1, S. Silva2, E. Stoddard2, J. V. Odom3. 1Mumford Institute, Highlands, NJ; 2After-School All- Stars of NY CampUs, New York, NY; 3WVU Eye Institute, Morgantown, WV *CR 5689 — C0160 Prevalence of Anisocoria and Association Between Age and Pupil Size in Children. Jillian Silbert1, N. S. Matta1, J. Tian2, E. Singman2, D. I. Silbert1. 1Vision Research Department, Family Eye Group, Lancaster, PA; 2 Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD *CR 5690 — C0161 Mutation analysis in patients suspected to have PAX6-related ocular malformations. Daniel Gratie, E. M. Stone, J. East, R. F. Mullins, A. V. Drack. Ophthalmology, University of Iowa, Iowa City, IA *CR 5692 — C0163 Quality Improvement in the Ophthalmic Care of Patients with Down Syndrome through a Comprehensive, CenterBased Model. Daniel Hammer, S. M. Culican. Washington University in Saint Louis, Saint Louis, MO Thursday, May 09, 2013 8:30 AM-10:15 AM Clinical/Epidemiologic Research 513 Myopia, CL Moderators: Jane E. Gwiazda and Donald O. Mutti 5693 — C0164 Predicting the onset of myopia: a retrospective study. Bjorn Drobe1, R. de SaintAndré2, 3. 1R&D Singapore, Essilor International, Singapore, Singapore; 2Sarl Roger de Saint-André, Gaillac, France; 3Centre d’Optométrie, Université Paris-Sud (Paris 11), Faculté des Sciences d’Orsay, Les Ulis, France *CR 5694 — C0165 A genome-wide association study for simple myopia and hyperopia in Twin Eye Study population. Li Deng. Vision Science, New England College of Optometry, Boston, MA 5695 — C0166 Heritability of Myopia and Ocular Biometrics in Koreans: The Healthy Twin Study. Tae-Young Chung, D. Lim, M. Kim, M. Lee, E. Chung. Samsung Medical Center, Seoul, Republic of Korea 5696 — C0167 Larger refractive group differences in visual activities are found in children than in young adults. Kara E. Gerger, J. E. Gwiazda. The New England Coll of Optom, Boston, MA 5697 — C0168 Refractive Errors and Ocular Biometry in Singapore Adults: The Singapore Epidemiology of Eye Disease (SEED) Study. Gus Gazzard1, 2, C. Pan3, Y. Zheng4, 5, A. R. Anuar4, P. Mitchell6, T. Aung5, 4, C. Cheng4, 3, T. Y. Wong4, 3, S. Saw3, 4. 1Institute of Ophthalmology, UCL, London, United Kingdom; 2NIHR Biomedical Research Centre, London, United Kingdom; 3Saw Swee Hock School of Public Health, Singapore, Singapore; 4 SERI, Singapore Eye Research Institute, Singapore, Singapore; 5SNEC, Singapore National Eye Centre, Singapore, Singapore; 6University of Sydney, Sydney, NSW, Australia *CR 5698 — C0169 Outdoor activity exhibit protective effect for myopia in children having a moderate near workload. Yuanbo Liang1, 2, Z. Lin3, 2, B. Vasudevan4, V. Jhanji2, T. Gao5, N. Wang3, K. J. Ciuffreda6. 1Clinical Research Center, The Joint Shantou International Eye Center (JSIEC) of Shantou, Shantou, China; 2Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China; 3 Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing, China; 4College of Optometry, Mid Western University, Glendale, AZ; 5Handan Eye Hospital, Handan, China; 6Department of Biological and Vision Sciences, SUNY College of Optometry, New York, NY 5699 — C0170 The effect of light intensity and accommodation on short-term axial length changes in myopes and emmetropes. Emma Chu, J. E. Gwiazda. Vision Science, New England College of Optometry, Boston, MA 5700 — C0171 International educational performance and myopia - a role for cram schools? Ian G. Morgan1, K. A. Rose2. 1Research School of Biology, Australian National University, Canberra, ACT, Australia; 2Discipline of Orthoptics, University of Sydney, Sydney, NSW, Australia 5701 — C0172 Age of Spectacle Wear as a proxy for myopia severity in genetic studies. Katie M. Williams1, P. G. Hysi1, A. Nag1, E. Yonova1, C. Venturini1, 2, C. J. Hammond1. 1Departments of Ophthalmology and Twin Research, King’s College London, London, United Kingdom; 2Institute of Ophthalmology, University College London, London, United Kingdom 5702 — C0173 Prevalence of myopia at age 6 in a Dutch Birth Cohort Study: The Generation R Study. Jan Roelof Polling1, 2, R. Gaillard3, A. Hofman4, V. Jaddoe3, J. R. Vingerling1, 4, C. C. Klaver1, 4. 1Ophthalmology, Erasmus MC, Rotterdam, Netherlands; 2Orthoptics & Optomery, University of Applied Sciences, Utrecht, Netherlands; 3Generation R Study Group, Erasmus MC, Rotterdam, Netherlands; 4Epidemiology, Erasmus MC, Rotterdam, Netherlands *CR 5703 — C0174 Peripheral Refraction in a Population of Schoolage Children in Central China: the Anyang Childhood Eye Study. ShiMing Li1, S. Li1, N. Wang1, P. Mitchell2. 1Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing, China; 2Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, ACT, Australia *CR 5704 — C0175 Scleral Encircling Acceleration or Deceleration of Myopic Progression in Myopic Eyes. Changho Kim, S. Kim. Ophthalmology, Severance hospital, Yonsei Univ College of Medicine, Seoul, Republic of Korea 5705 — C0176 Curry consumption and high myopia in adults: A possible protective effect. Ainur R. Anuar2, 1, Y. Zheng1, 3, L. Huang1, B. Mani1, C. Y. Cheung1, C. Cheng1, M. Chew1, J. S. Mehta1, 5, T. Y. Wong1, 4, T. Aung1, 4. 1Epidemiology, Singapore Eye Research Institute, Singapore, Singapore; 2Ophthalmology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 3 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China; 4Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; 5Duke-NUS Graduate Medical School of Medicine, National University of Singapore, Singapore, Singapore *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 361 Thursday Posters 8:30 am – 10:15 am 5691 — C0162 Risk Factors of Astigmatism in the Vision in Preschoolers (VIP) Study. Jiayan Huang1, G. Ying1, M. G. Maguire1, G. E. Quinn2, M. T. Kulp3, E. Ciner4, L. A. Cyert5, D. A. Orel-Bixler6, B. Moore7. 1University of Pennsylvania, Philadelphia, PA; 2Children’s Hospital of Philadelphia, Philadelphia, PA; 3Ohio State University, Columbus, OH; 4Salus University, Elkins Park, PA; 5Northeastern State University, Tahlequah, OK; 6University of California, Berkeley, CA; 7New England College of Optometry, Boston, MA *CR Exhibit Hall C0164-C0189 5706 – 5727 – Thursday – Posters 5706 — C0177 Comparison of Cycloplegic refraction between Retinoscopy, Closed field and Open field autorefraction in Pseudomyopia. Jameel Rizwana Hussaindeen, K. Ramani. Elite School of Optometry, Sankara Nethralaya, Unit of Medical Research Foundation, Chennai, India 5707 — C0178 Eye shape and peripheral refraction as predictors of myopia progression in a population of Chinese children. David Troilo1, L. Jiang2, A. Benavente-Perez1, X. Zhou2, F. Lu2, J. Qu2. 1SUNY College of Optometry, New York, NY; 2 Wenzhou Medical College, Wenzhou, China 5708 — C0179 Three-Dimensional Modeling of Highly Myopic Human Eyes Using Optical Coherence Tomography Imaging. Yumiko AkagiKurashige, K. Yamashiro, M. Miyake, A. Oishi, A. Tsujikawa, M. Hangai, N. Yoshimura. Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan *CR 5709 — C0180 Biometric characteristics of the Marfan eye: From the Marfan Eye Consortium of Chicago. Sarah Wehrli2, 1, M. Mets1, 2, I. S. Kassem3, 1, A. A. Fawzi2, 1, N. F. Azar3, 1, I. H. Maumenee3, 1. 1Lurie Children’s Hospital of Chicago, Chicago, IL; 2Northwestern, Chicago, IL; 3 UIC, Chicago, IL 5710 — C0181 Implementation of atropine treatment for progressive myopia in children. Ruben Kok1, J. Polling1, 2, C. C. Klaver1, 3. 1 Ophthalmology, Erasmus MC Rotterdam, the Netherlands, Rotterdam, Netherlands; 2Optometry & Orthoptics, University of Applied Sciences, Utrecht, Netherlands; 3Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands *CR Thursday Posters 8:30 am – 10:15 am 5711 — C0182 The Economic Cost of Myopia in Singapore. Seang-Mei Saw1, 2, Y. Zheng2, J. Chay3, C. Pan1, E. L. Lamoureux2, 3, E. A. Finkelstein3, 1, T. Y. Wong2, 4. 1Saw Swee Hock School of Public Health, National Univ of Singapore, Singapore, Singapore; 2Singapore Eye Research Institute, Singapore Eye Research Institute, Singapore, Singapore; 3HSSR, DukeNUS Graduate Medical School, Singapore, Singapore; 4Ophthalmology, National University Health System, National University of Singapore, Singapore, Singapore *CR 5712 — C0183 Correlation in Myopia Progression between right and left eyes in Chinese children with Myopia. Padmaja Sankaridurg1, 2, B. A. Holden1, 3, X. Chen4, 2, A. Ho1, 3, L. Li4, 2, L. Donovan1, 2, J. Ge4. 1Optometry, Brien Holden Vision Institute, Sydney, NSW, Australia; 2 Research, Vision Cooperative Research Centre, Sydney, NSW, Australia; 3School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, Australia; 4State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Guangzhou, China *CR, f 5713 — C0184 Prevalence of myopia in Chinese urban and rural children. Mingzhi Zhang. Ophthalmology, Joint Shantou International Eye Center, Shantou, China 5714 — C0185 Refractive Errors and AgeRelated Macular Degeneration: A Systematic Review and Meta-Analysis. Chen Wei Pan1, M. K. Ikram2, 3, C. Y. Cheung2, 3, G. C. Cheung2, 3 , J. B. Jonas4, T. Y. Wong2, 3, S. Saw1, 2. 1Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; 2 Singapore Eye Research Institute, Singapore, Singapore; 3Ophthalmology, National University of Singapore, Singapore, Singapore; 4Ophthalmology, Medical Faculty Mannheim of the Ruprecht-KarlsUniversity Heidelberg, Mannheim, Germany *CR 5721 — C0192 The global burden of visual difficulty. Fawzia Djafari1, 2, S. Haddad3, M. Aubin1, 2, M. Roy-Gagnon1, C. Vela1, E. E. Freeman1, 2. 1Maisonneuve-Rosemont hospital, Montréal, QC, Canada; 2Ophthalmology, Université de Montréal, Montreal, QC, Canada; 3Centre de Recherche, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada 5715 — C0186 Longitudinal anterior globe width growth depends on refractive error. Melissa D. Bailey, N. G. Satiani, L. T. Sinnott. Optometry, Ohio State University, Columbus, OH 5722 — C0193 Improving Visual Prognosis of Glaucoma Patients during 30 Years based on the Data of the Finnish Register of Visual Impairment. Hannu M. Uusitalo1, 2, A. Siitonen1, M. Ojamo2. 1Department of Ophthalmology, SILK, University of Tampere, Tampere, Finland; 2Finnish Register of Visual Impairment, THL, Helsinki, Finland 5716 — C0187 Macular Thickness in Myopic and Mon-myopic Young Adults. Leslie Hyman1, J. E. Gwiazda2, E. Harb2, W. L. Marsh-Tootle3. 1 Preventive Medicine, Stony Brook Medicine, Stony Brook, NY; 2New England College of Optometry, Boston, MA; 3UAB College of Optometry, University of Alabama at Birmingham, Birmingham, AL 5723 — C0194 A New Computerized Autoacuity Test for Assessment of the Visual Acuity of Pre-school Children. Mingxing Wu1, Y. Qin1, L. Liu1, S. Ye1, M. Fu3, Z. Liu1, Y. Tsau2. 1Cataract, Zhongshan Ophthalmic Center, Guangzhou, China; 2Dimetek Digital Medical Technologies, Limited, Shenzhen, China; 3Shenzhen Children and Women Hospital, Shenzhen, China 5717 — C0188 Vitamin D receptor gene polymorphisms and the risk of myopia. Jeremy A. Guggenheim1, K. Northstone2, G. McMahon2, B. St Pourcain2, C. Williams2. 1Centre for Myopia Research, Hong Kong Polytechnic University, Kowloon, Hong Kong; 2School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom 5724 — C0195 Longitudinal Relationships between Visual Acuity and Depressive Symptoms: the Salisbury Eye Evaluation Study. Dandan D. Zheng1, S. L. Christ2, S. K. West3, B. E. Munoz3, B. K. Swenor3, B. L. Lam4, D. J. Lee1, 4. 1 Epidemiology & Public Health, University of Miami, Miami, FL; 2Human Development and Family Studies, Purdue University, West Lafayette, FL; 3Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, FL; 4Bascom Palmer Eye Institute, University of Miami, Miami, FL 5718 — C0189 What is the ‘real’ baseline for the rate of progress of myopia for a child?The rate of progress of myopia with and without spectacle vision correction. Li Li2, 1, P. Sankaridurg1, T. J. Naduvilath1, X. Chen2, Z. Lin2, B. A. Holden1. 1Brien Holden Vision Institute, Sydney, NSW, Australia; 2Zhongshan Ophthalmic Center, Guangzhou, China *CR, f Exhibit Hall C0190-C0200 Thursday, May 09, 2013 8:30 AM-10:15 AM Clinical/Epidemiologic Research 514 Vision Impairment Moderators: Priya M. Mathews and Tunde Peto 5719 — C0190 The utility of routine testing for tuberculosis in a county-hospital uveitis population. An analysis of predictive values. Bryan K. Hong, S. R. Bababeygy, H. Nazari Khanamiri, N. A. Rao. Ophthalmology, Doheny Eye Institute, LAC & USC, Los Angeles, CA 5720 — C0191 Correlation of Ophthalmic Screening Tests in an American Indian/Alaskan Native Cohort. Laura J. Kopplin1, D. Choi3, S. L. Mansberger2. 1Casey Eye Institute, Portland, OR; 2 Devers Eye Institute, Portland, OR; 3Public Health & Preventive Medicine, Oregon Health and Science University, Portland, OR *CR 5725 — C0196 The Vision In Stroke (VIS) study: Profile of visual impairment following stroke. Fiona J. Rowe. Orthoptics and Vision Science, University of Liverpool - Sydney Jones Library, Liverpool, United Kingdom 5726 — C0197 Vision Impairment and Eye Care Utilization Among Older Adults Residing in Assisted Living. Amanda Elliott1, G. McGwin2, 3, C. Owsley2. 1Nursing, University of South Florida, Tampa, FL; 2Ophthalmology, University of Alabama at Birmingham, Birmingham, AL; 3Epidemiology, University of Alabama at Birmingham, Birmingham, AL *CR 5727 — C0198 Refractive Error And Cause Of Vision Impairment Among Children In A Low Vision Service. Dawn K. DeCarlo1, G. McGwin1, 2, E. L. Forte1, L. Gao1, C. Owsley1. 1Ophthalmology, Univ of Alabama at Birmingham, Birmingham, AL; 2Epidemiology, University of Alabama at Birmingham, Birmingham, AL *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 362 Thursday – Posters – 5728 – 5749 5728 — C0199 Estimation of design effect, sample size and number of clusters needed for trachoma prevalence surveys. Beatriz E. Munoz1, J. King2, J. M. Ngondi3, P. Emerson2, S. K. West1. 1 Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, MD; 2Carter Center, Atlanta, GA; 3 Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambrige, United Kingdom 5729 — C0200 Visual Acuity and Associated Risk Factors in indigenous and non-indigenous Mexican population. Jesus Arrieta-Camacho, E. O. Graue-Hernández, A. J. Ramirez-Miranda, A. Jimenez-Corona. Anterior Segment, Inst de Oftalmologia CONVAL, Mexico City, Mexico *CR Exhibit Hall C0201-C0224 Thursday, May 09, 2013 8:30 AM-10:15 AM Lens 515 Chemical Composition and Physical Properties Moderator: Ales Cvekl 5730 — C0201 The viscosity of the lens. Mai T. Thao1, D. S. Perez1, J. P. Dillon1, E. R. Gaillard1, 2. 1 Chemistry and Biochemistry, Northern Illinois University, Dekalb, IL; 2Biology, Northern Illinois University, Dekalb, IL 5731 — C0202 Resting Potential of Rat Crystalline Lens. Sebastiao Cronemberger1, V. V. Oliveira2, R. Fleming2, N. S. Calixto1, A. Dantas2. 1 Ophthalmology, Federal University of Minas Gerais, Belo Horizonte, Brazil; 2Ophthalmology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil 5732 — C0203 Conformational characteristics of proteins and lipids in transparent human lenses and lenses with cortical opacities - A Raman spectroscopic study. Ralph Michael1, C. Otto2, A. Lenferink2, G. A. Montenegro1, R. I. Barraquer1, G. Vrensen3. 1Institut Universitari Barraquer, Barcelona, Spain; 2Medical Cell Bio Physics, University of Twente, Enschede, Netherlands; 3Leiden University Medical Center, University of Leiden, Leiden, Netherlands 5735 — C0206 The Spectrin-Actin Network and Beaded Filaments Cooperate to Assemble Large Gap Junction Plaques, Facilitating Normal Ion Homeostasis in Mouse Lens Fiber Cells. Velia M. Fowler1, R. B. Nowak1, J. Gao2, R. T. Mathias2, S. K. Biswas3, W. Lo3. 1Cell Biology, Scripps Research Institute, La Jolla, CA; 2 Physiology and Biophysics, State University of New York at Stonybrook, Stony Brook, NY; 3 Neurobiology, Morehouse School of Medicine, Atlanta, GA 5736 — C0207 Filensin and CP49 expression are not restricted to lens fiber cells. Paul G. FitzGerald1, R. A. Quinlan2. 1Cell Biol & Human Anatomy, Univ of California, Davis, Davis, CA; 2 Biophysical Sciences Institute, Durham University, Durham, United Kingdom 5737 — C0208 A Putative glutathione transporter identified in mouse lens with glutathione de novo synthesis deficiency (LEGSKO) is also elevated in aged human lens. Xingjun Fan. Pathology, Case Western Reserve Univ, Cleveland, OH 5738 — C0209 Metabolite and lipid mapping in normal and functionally perturbed ocular lens by MALDI imaging mass spectrometry. Angus C. Grey1, M. G. Nye-Wood1, J. M. Spraggins3, R. M. Caprioli4, 3, K. L. Schey4, 3, P. J. Donaldson2. 1 Optometry and Vision Science, University of Auckland, Auckland, New Zealand; 2School of Medical Sciences, University of Auckland, Auckland, New Zealand; 3Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN; 4Biochemistry, Vanderbilt University, Nashville, TN 5739 — C0210 Discovery of key proteins involved in Parkinson’s disease and Alzheimer’s disease in human eyes. Chunmei He1, J. Zhang2, 1, T. T. Shen1. 1Ophthalmology, University of Washington, Seattle, WA; 2Pathology, University of Washington, Seattle, WA 5740 — C0211 Danio rerio αB1-crystallin encodes for an activated chaperone. Hanane A. Koteiche, S. Mishra, H. S. Mchaourab. Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 5741 — C0212 Assessing the zebrafish as an efficient model for analyzing mammalian α-crystallin transcriptional regulation. Mason Posner, Z. Haley, A. Drossman. Biology, Ashland University, Ashland, OH 5742 — C0213 Kinetics of Diabetes Related Modifications in Heat Shock Proteins. Devi Kalyan Karumanchi1, E. R. Gaillard1, 2, J. P. Dillon1. 1Department of Chemistry and Biochemistry, Northern Illinois University, Dekalb, IL; 2Department of Biology, Northern Illinois University, Dekalb, IL 5743 — C0214 UVA light through sensitization of kynurenines oxidizes ascorbate and promotes lens protein modification: Implications for lens aging and cataract formation. Cibin T. Raghavan1, M. D. Linetsky2, R. H. Nagaraj1. 1Ophthalmology, Case Western Reserve University, Cleveland, OH; 2 Chemistry, Case Western Reserve University, Cleveland, OH 5744 — C0215 Stimulation of Glycolysis in the Lens by Pyruvate. Implications in Protection against Oxidative Stress. Kavita R. Hegde1, S. D. Varma2. 1Natural Sciences, Coppin State University, Baltimore, MD; 2Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 5745 — C0216 Patterns of Cellular Expression and Self Assembly of Human Amyloid Proteins in vivo. Owen Lawrence1, J. L. Dodge1, J. M. Clark1, J. I. Clark1, 2. 1Biological Structure, University of Washington, Seattle, WA; 2 Ophthalmology, University of Washington, Seattle, WA 5746 — C0217 Domain Structure of Reconstituted Cortical and Nuclear Human Lens Lipid Membranes. Laxman Mainali1, M. Raguz1, 3, W. J. O’Brien2, W. K. Subczynski1. 1Biophysics, Medical College of Wisconsin, Milwaukee, WI; 2 Ophthalmology and Microbiology/Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI; 3Medical Physics and Biophysics, University of Split, Split, Croatia 5747 — C0218 Mice Expressing CRYAAN101D Show Altered Membrane Structure and Increased Membrane-Association of Deamidated αA Compared to CRYAA Wild-Type (WT) Mice. Kiran Srivastava, R. Joseph, S. M. Hegde, O. P. Srivastava. Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 5748 — C0219 Probing structure of human β-crystallins by protein cross-linking. Kirsten J. Lampi1, L. L. David2. 1Integrative Biosciences, Oregon Health and Science University, Portland, OR; 2Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 5749 — C0220 Oxygen Metabolism in Primary Human Lens Epithelial Cells. Miyuki Kubota1, 2, C. J. Siegfried1, Y. Shui1, F. Bai1, A. J. Huang1, D. C. Beebe1, 3. 1Ophthalmology & Visual Sciences, Washington University School of Medicine, St Louis, MO; 2Ophthalmology, Keio University School of Medicine, Tokyo, Japan; 3Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 363 Thursday Posters 8:30 am – 10:15 am 5733 — C0204 Fiber Cell Compaction in Adult Human Lenses Begins Near the Remodeling Zone in the Outer Cortex. M J. Costello1, A. Mohamed2, K. Gilliland1, W. C. Fowler3, S. Johnsen4. 1Cell Biology & Physiology, University of North Carolina, Chapel Hill, NC; 2Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India; 3Ophthalmology, University of North Carolina, Chapel Hill, NC; 4 Biology, Duke University, Durham, NC 5734 — C0205 The Tropomodulin1-Actin Network and CP49 Beaded Filaments Regulate Formation of Undulating Aquaporin Junctions in Mouse Lens Fiber Cells. Sondip K. Biswas1, R. B. Nowak2, V. M. Fowler2, W. Lo1. 1Neurobiology, Morehouse School of Medicine, Atlanta, GA; 2Cell Biology, The Scripps Research Institute, La Jolla, CA 5750 – 5768 – Thursday – Posters 5750 — C0221 Gap junctional conductance produced by Cx50, but not Cx46, is regulated by the PI3K signaling pathway in the lens. Jennifer M. Martinez1, H. Wang1, P. V. Mhaske1, C. Sellitto1, M. Srinivas2, R. Z. Lin1, T. W. White1. 1Physiology, Stony Brook University, Patchogue, NY; 2Biological Sciences, State University of New York- College of Optometry, New York, NY 5756 — D0003 A prospective study on Terson’s syndrome and intraocular infections in critically ill patients. Daniel Barthelmes1, 2, M. Haenggi2, T. M. Merz2, J. Takala2, M. Lensch2, S. M. Jakob2. 1 Ophthalmology and Eye health, The University of Sydney, Sydney, NSW, Australia; 2Intensive Care Medicine, University Hospital Bern, Bern, Switzerland 5751 — C0222 Cell transduction of αA-crystallin is negatively impacted by phosphorylation mimics. Niklaus H. Mueller, K. L. Christopher, D. A. Ammar, J. M. Petrash. Ophthalmology, Univ of Colorado School of Medicine, Aurora, CO *CR 5757 — D0004 Torsion-Induced Traumatic Optic Neuropathy (TON). Matthew A. Reilly1, R. E. Sponsel1, 2, R. D. Glickman3. 1Biomedical Engineering, University of Texas at San Antonio, San Antonio, TX; 2WESMDPA, San Antonio, TX; 3Ophthalmology, University of Texas Health Science Center San Antonio, San Antonio, TX *CR 5752 — C0223 αB-Crystallin secretion from astrocytes and its implications for Alzheimer’s Disease. Juliet A. Moncaster1, 2, J. Ghosh1, T. Ikezu2, J. C. Voss3, R. K. Gangalum4, S. Sarangi1, C. R. Abraham2, S. P. Bhat4, P. K. Stanton5, L. E. Goldstein1, 2. 1Psychiatry, School of Medicine, Boston University, Boston, MA; 2BU Alzheimer’s Disease Center, School of Medicine, Boston University, Boston, MA; 3Biochemistry and Molecular Medicine, UC Davies, Sacramento, CA; 4 Ophthalmology, Jules Stein Eye Institute, Los Angeles, CA; 5Cell Biology and Anatomy, New York Medical College, Valhalla, NY *CR 5753 — C0224 Chaperone peptides of α-crystallin inhibit cataract formation in rats. Rooban B. Nahomi1, B. Wang2, C. T. Raghavan1, O. Voss3, A. Doseff3, P. Santhoshkumar4, R. H. Nagaraj1. 1Ophthalmology, Case Western Reserve University, Cleveland, OH; 2Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH; 3Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH; 4Ophthalmology, University of Missouri, Columbia, MO Exhibit Hall D0001-D0006 Thursday, May 09, 2013 8:30 AM-10:15 AM Retina 516 Trauma Thursday Posters 8:30 am – 10:15 am Moderator: Hugo Quiroz-Mercado 5754 — D0001 High-Power Blue Laser PointerInduced Maculopathy. sulaiman M. Alsulaiman1, A. A. Alrushood1, J. Almasaud1, S. Alzaaidi1, Y. A. Alzahrani1, J. Arevalo1, 2, N. G. Ghazi1, E. B. Abboud1, S. Alreshaid1. 1King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 2Wilmer Eye Institute, Baltimore, MD 5755 — D0002 The effects of repeated exposure to low level blast overpressure on rat ocular tissues. Jae Hyek Choi1, 2, W. A. Greene1, 2, M. Chavko3, A. J. Johnson2, J. M. Cleland2, H. H. Wang2. 1National Research Council, Washington, DC; 2Ocular Trauma Department, U.S. Army Institute of Surgical Research, Fort Sam Houston, TX; 3NeuroTrauma Department, Naval Medical Research Center, Silver Spring, MD 5758 — D0005 Pars Plana Vitrectomy with medium-term Perfluoro-N-Octane for severe ocular trauma and hemorrhage with or without retinal detachment. Ramanath Bhandari1, S. Schwartz2, C. Gonzalez2, R. Victoria2, N. Mandava1, H. Quiroz-Mercado2. 1Ophthalmology, Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, Aurora, CO; 2 Ophthalmology, Denver Health Medical Center, Denver, CO *CR 5762 — D0009 Rescue Laser Photo Stimulation for Diabetic Macular Edema Unresponsive to Anti-VEGF Therapy. Jose A. Cardillo1, 2, A. J. Dare4, R. Peroni3, 4, R. Jorge2. 1Retina Department, Universidade Federal de São Paulo, São Paulo, Brazil; 2Retina Department, Universidade de São Paulo, Ribeirão Preto, Brazil; 3Retina Department, Hospital de Olhos de Araraquara, Araraquara, Brazil; 4Retina Department, Centro Brasileiro de Especialidades Oftalmológicas, Araraquara, Brazil 5763 — D0010 A Simple Artificial Eye Model for Practicing Anterior and Posterior Segment Lasers. Malav Joshi, T. W. Altenbernd. Ophthalmology and Vision Science, University of Arizona, Tucson, AZ Exhibit Hall D0011-D0057 Thursday, May 09, 2013 8:30 AM-10:15 AM Retina 518 Vitreoretinal Surgery III Moderator: Elliott H. Sohn 5759 — D0006 Outcome of Retinal Surgery in Eyes with Ruptured Globes. Khoa V. Lam1, D. Xing2, E. K. Chin2, S. S. Park2. 1UC Davis School of Medicine, Davis, CA; 2Department of Ophthalmology & Vision Science, Univ of California Davis Eye Ctr, Sacramento, CA 5764 — D0011 The Effect of Internal Limiting Membrane Peeling in Epiretinal Membrane Including Pseudolamellar Macular Hole. Jung Min Park1, S. Oh1, S. Lee2. 1Ophthalmology, Maryknoll Hospital, Busan, Republic of Korea; 2 Ophthalmology, Haeundae paek hospital, Busan, Republic of Korea Exhibit Hall D0007-D0010 5765 — D0012 Clinical Findings at Initial Pan Retinal Photocoagulation for Proliferative Diabetic Retinopathy Predict Future Need for Pars Plana Vitrectomy. Ravi Parikh1, 4, J. Van Houten3, E. F. Cherney2. 1School of Medicine, Vanderbilt University, Nashville, TN; 2Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN; 3Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN; 4Health Policy and Management HSPH, Harvard University, Boston, MA Thursday, May 09, 2013 8:30 AM-10:15 AM Retina 517 Laser/Intravitreal Treatment Moderator: Robert L. Avery 5760 — D0007 A comparison of anti-VGEF therapy and laser in preserving visual function in patients with proliferative diabetic retinopathy. Marisol Estudillo, V. H. Gonzalez. OpthalmologyRetina, Valley Retina Institute,PA, McAllen, TX *CR, f 5761 — D0008 Intravitreal Ranibizumab Combined with Panretinal Photocoagulation in Patients with Treatment-Naive Proliferative Diabetic Retinopathy. Daniel A. Ferraz1, 2, R. Sophie2, M. G. Bittencourt2, R. C. Preti1, L. M. Vazquez1, A. A. Motta1, M. Hanout2, Y. J. Sepah2, Q. Nguyen2, W. Y. Takahashi1. 1Ophthalmology, University of São Paulo, São Paulo, Brazil; 2Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD *CR 5766 — D0013 Retinal ganglion cell layer thickness reduces after internal limiting membrane peeling during macular hole surgery. Adil Darugar, V. Caillaux, A. Erginay, B. M. Dupas, V. Krivosic, J. Perol, S. Bruneau, A. Gaudric, P. Massin, R. Tadayoni. Department of Ophthalmology, Hôpital Lariboisière, Université Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris, France, Paris, France *CR 5767 — D0014 Trends in choice of surgical technique and reimbursement for retinal detachment repair. Baseer Ahmad, G. K. Shah, K. J. Blinder. The Retina Institute / Retina Consultants of St. Louis, St. Louis, MO *CR 5768 — D0015 Retained Lens Fragments After Cataract Surgery: Outcomes of Same-Day Versus Delayed Pars Plana Vitrectomy. Yasha S. Modi, A. E. Epstein, W. E. Smiddy, W. J. Feuer, H. W. Flynn. Ophthalmology, Bascom Palmer Eye Institute, Miami, FL *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 364 Thursday – Posters – 5769 – 5790 5769 — D0016 Anatomical outcomes of epiretinal membrane surgery with or without internal limiting membrane peeling. Sheyman, J. S. Myung, T. Lyu, K. Wald. Department of Ophthalmology, Mount Sinai School of Medicine, New york, NY 5778 — D0025 Retinal Vascular Remodeling Following Macular Hole Surgery. Gene Chen1, R. Iezzi1, J. W. McLaren1, R. C. Gentile2, A. J. Barkmeier1. 1Ophthalmology, Retina, Mayo Clinic, Rochester, MN; 2Ophthalmology, Retina, New York Eye and Ear Infirmary, New York City, NY 5770 — D0017 One-year anatomical and functional outcomes after macular hole surgery: a prospective controlled study. Sumeer Thinda, R. J. Shah, S. J. Kim. Ophthalmology, Vanderbilt Univ Medical Center, Nashville, TN f 5779 — D0026 One-year results of the Prospective Retinal and Optic nerve Vitrectomy Evaluation (PROVE) Study: A controlled clinical trial. Rohan J. Shah, M. Lalezary, S. J. Kim, R. Reddy, J. Kammer, R. W. Kuchtey, K. M. Joos, F. Recchia, E. F. Cherney, J. C. Law. Department of Ophthalmology, Vanderbilt University, Nashville, TN *CR, f 5771 — D0018 Retrospective analysis of laser therapy versus observation for symptomatic retinal artery macroaneurysms. Jacob C. Meyer, G. K. Shah. The Retina Institute, St. Louis, MO *CR 5772 — D0019 Ultrastructural changes of the vitreoretinal interface during longterm followup after the removal of the internal limiting membrane. Toshio Hisatomi1, 2, H. Enaida1, S. Notomi1, Y. Sassa1, A. Takeda1, T. Ishibashi1. 1 Ophthalmology, Kyushu Univ., Fukuoka, Japan; 2 Clinical Research Institute, Kyushu Medical Center, Fukuoka, Japan *CR 5773 — D0020 Evaluation of Brilliant Blue Green (BBG) Toxicity on Retinal Ganglion Cells Exposed to Varying levels of Illumination with Surgical Metal Halide Endoilluminator. K V Chalam, W. Li, S. Balaiya. Ophthalmology, Univ of Florida-Jacksonville, Jacksonville, FL 5774 — D0021 Outcomes of Transpupillary Posterior Chamber Intraocular Lens Removal with Pars Plana Vitrectomy and Placement of Anterior Chamber Intraocular Lens. Pavlina Kemp, A. T. Johnson, J. C. Folk, S. R. Russell, V. B. Mahajan, H. Boldt, T. A. Oetting, E. H. Sohn. Department of Ophthalmology, University of Iowa, Iowa City, IA *CR 5775 — D0022 Microfiltration of Brilliant Blue G Dye. Sri Krishna Mukkamala. 1Ophthalmology, Columbia University, New York, NY; 2Vitreous Retina Macula Consultants, New York, NY 5776 — D0023 Traumatic Optic Neuropathy after Vitrectomy Surgery: A controlled prospective trial. Sivashakthi Kanagalingam, M. Lalezary, S. J. Kim. Ophthalmology, Vanderbilt University Medical Center, Nashville, TN f 5781 — D0028 Quantitative assessment of Differences in Macular Visibility through a Variety of Intraocular Lenses during Vitrectomy: an Eye Model Experimental Study. Hirokazu Sakaguchi1, J. Hidaka2, Y. Oshima1, N. Maeda1, K. Nishida1. 1Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan; 2HOYA Corporation Medical Division, Itabashi, Japan *CR 5782 — D0029 Risk factors for development of full thickness macular holes following pars plana vitrectomy for myopic foveoschisis. Yasushi Ikuno, X. Gao, S. Fujimoto, K. Nishida. Department of Ophthalmology, Osaka Univ Medical School, Suita, Japan *CR 5783 — D0030 Clinical Efficacy and Safety of Dexamethasone/Netilmicin Gel in the Management of Ocular Inflammation After Vitreoretinal Surgery. Vincenzo Papa1, D. Rasà1, C. Iannacone3, C. Cannatella1, A. Rapisarda2. 1 Medical Affairs, SIFI SPA, Catania, Italy; 2 Ophthalmology Unit, Garibaldi Hospital, Catania, Italy; 3Department of Statistics, Sparc Consulting Srl, Milano, Italy *CR, f 5784 — D0031 Cone implicit time as a predictor for visual outcome in Macular Hole Surgery. Sten Andreasson, S. Kjellstrom, H. Barth, F. K. Ghosh. Ophthalmology, University Hospital of Lund, Lund, Sweden 5786 — D0033 Diluted Preserved Triamcinolone Acetonide for Internal Limiting Membrane Staining: Staining Morphology and Cytotoxicity Evaluations. Jerry Huang1, L. Yeung1, N. Wang2, Y. Chen2, Y. Hwang2, K. Chen2, W. Wu2, T. Chen2, C. Lai2. 1Chang-Gung Memorial Hospital, Keelung, Taiwan, Keelung City, Taiwan; 2 Chang-Gung Memorial Hospital, Taoyuan, Taiwan, Guishan Township, Taoyuan County, Taiwan 5787 — D0034 A computational study of the pressure burden on localized retina during vitrectomy. Yong Joon Kim1, K. Choi1, S. Jo2, Y. Joo2. 1Department of Ophthalmology, Soonchunhyang University, College of Medicine, Seoul, Republic of Korea; 2Department of Mechanical Engineering, Soonchunhyang University, Asan, Republic of Korea 5788 — D0035 Iatrogenic retinal breaks in 25-gauge air vitrectomy compared with the standard 25-gauge system for macular diseases. Cesare Mariotti1, F. Viti1, T. Avitabile2, M. D. Toro2, A. Saitta1, A. Giovannini1, A. Longo2, V. De Grande2, S. Stella2, M. Reibaldi2. 1Clinica Oculistica, Universita Politecnica delle Marche, Ancona, Italy; 2Ophthalmology, University of Catania, Catania, Italy 5789 — D0036 Dynamic Contour Tonometry versus Goldmann Applanation Tonometry after vitrectomy. Nikolaos Mamas, M. Fuest, G. Roessler, B. A. Mazinani, N. Plange. Ophthalmology, RWTH Aachen University, Aachen, Germany *CR 5790 — D0037 Macular hole repair closure rates in phakic and non-phakic patients with nonsupine positioning and sulfur hexafluoride endotamponade. Jaafar El Annan1, J. Heffez3, J. D. Udoetuk1, M. M. Sanghvi2, P. E. Carvnounis1. 1 Ophthalmology, Baylor College of Medicine, Houston, TX; 2George Washington University School of Medicine and Health Sciences, Washington, DC; 3Retina Consultants P.C., Washington, DC *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 365 Thursday Posters 8:30 am – 10:15 am 5777 — D0024 Macular hole surgery: Does C3F8 provide better anatomical and functional outcomes than SF6 and C2F6? Javier ZarranzVentura1, 2, A. Sallam1, P. A. Keane2, D. A. Sim2, N. Kirkpatrick1, R. Johnston1. 1Vitreo-Retinal Service, Cheltenham General Hospital, Cheltenham, United Kingdom; 2Medical Retina Service, National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom *CR 5780 — D0027 Association of M2 macrophages in the development of fibrovascular membranes in diabetic retinopathy. Yoshiyuki Kobayashi1, S. Yoshida1, S. Nakao1, T. Tachibana1, T. Nakama1, K. Ishikawa1, Y. Sassa1, 2, H. Enaida1, Y. Oshima1, T. Ishibashi1. 1Ophthalmology, Kyushu University, Fukuoka, Japan; 2Ophthalmology, Fukuoka University Chikushi Hospital, Fukuoka, Japan 5785 — D0032 One Year Clinical Outcomes Of A Randomized Clinical Trial Investigating Pre-operative Adjunctive Bevacizumab For Tractional Retinal Detachment (TRD) Due To Proliferative Diabetic Retinopathy (PDR). Elizabeth O. Tegins1, M. Javaheri2, D. Eliott4, 2, L. A. Kim2, 4, H. Salehi-Had2, 5, D. R. Hinton2, 3, E. H. Sohn1, 2. 1Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA; 2Doheny Eye Institute, University of Southern California and Los Angeles County Hospitals, Los Angeles, CA; 3Departments of Pathology and Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA; 4Massachusetts Eye and Ear Infirmary, Boston, MA; 5Atlantis Retina Institute, Huntington Beach, CA *CR, f 5791 – 5817 – Thursday – Posters 5791 — D0038 Efficacy of pneumatic displacement of sub macular haemorrhage (SMH) secondary to wet age related macular degeneration (ARMD). Indu Kumar, T. Papathomas, A. Kamal. Ophthalmology, Aintree University Hospital, Liverpool, United Kingdom 5792 — D0039 Movement of fovea toward optic disc after macular hole surgery with internal limiting membrane peeling. Kenichi Kawano1, Y. Ito1, M. Kondo1, 2, H. Terasaki1. 1 Opthalmology, Nagoya University, Nagoya, Japan; 2 Opthalmology, Mie University, Tsu, Japan 5793 — D0040 Course of Intra-Ocular Pressure After Vitreoretinal Surgery With Silicone Oil Injection: A Follow-Up of 5 Years. Elyse Jabbour1, G. Azar1, 2, J. Antoun1, A. Jalkh1, 2. 1 Ophthalmology, Eye & Ear University Hospital, Beirut, Lebanon; 2Department of Medicine, Université Saint Esprit Kaslik (USEK), Beirut, Lebanon 5794 — D0041 27-gauge sutureless microincision vitrectomy surgery for various retinal pathologies. Stanislao Rizzo, F. GenovesiEbert, F. Barca, E. Di Bartolo. UO Chirurgia Oftalmica, Azienda Ospedaliero-Univ Pisana, Pisa, Italy 5795 — D0042 Anatomic and functional followup of patients with an idiopathic epiretinal membrane and a preserved visual acuity. Arnaud Bonnabel, R. Isaico, A. M. Bron, C. CreuzotGarcher. Ophthalmology, General Hospital, Dijon, France *CR 5796 — D0043 To develop a new surgical strategy for removing emulsified droplets in the eye to reduce the complications associated the use of silicone oil (SO). Yau Kei J. Chan1, H. Shum2, S. Wong1. 1Department of Ophthalmology, University of Hong Kong, Pokfulam, Hong Kong; 2 Department of Mechanical Engineering, University of Hong Kong, Hong Kong, Hong Kong Thursday Posters 8:30 am – 10:15 am 5797 — D0044 Blood flow changes of the retina and choroid after vitrectomy for epiretinal membrane measured by laser speckle flowgraphy. Eiko Tsuiki, K. Suzuma, Y. Maekawa, T. Kitaoka. Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan 5798 — D0045 Vitreous oxygenation bioimplant for central retina artery occlusion. Raul Velez-Montoya, J. Olson. Ophthalmology, University of Colorado, Aurora, CO *CR 5799 — D0046 Epiretinal Membrane Peeling Following Uncomplicated Primary Retinal Detachment Repair. Kyle Godfrey1, T. Banker2, E. Weichel3, 2. 1Georgetown University School of Medicine, Washington, DC; 2Ophthalmology, Georgetown University Hospital, Washington, DC; 3 Retina Group of Washington, Washington, DC 5800 — D0047 Vitreous levels of MCP-1 and CD163 in vitreoretinal diseases. Takashi Tachibana, S. Yoshida, Y. Kobayashi, T. Nakama, K. Ishikawa, S. Nakao, Y. Sassa, H. Enaida, Y. Oshima, T. Ishibashi. Kyushu University, Fukuoka, Japan 5801 — D0048 Vitrectomy for macular hole secondary to blunt ocular trauma. Satomi Ohta, T. Baba, S. Yamamoto. Chiba University, Chiba, Japan 5802 — D0049 Rate of Elevated Intraocular Pressure Post Primary Vitrectomy Surgery. Milad Hakimbashi1, 2, K. A. Rezaei2, 1. 1 Ophthalmology, Rush University, Chicago, IL; 2Ophthalmology, Illinois Retina Associates, Chicago, IL *CR 5803 — D0050 An Experimental Proliferative Vitreoretinopathy (PVR) Model in Pigmented Rabbits for Testing of New Treatment. Lichun Zhong. Ocular Science Department, Toxikon Corporation, Bedford, MA 5804 — D0051 Light Microscopy Features of Epiretinal Membranes. Laura N. Distefano2, M. Dutra Medeiros5, A. Salas Torras2, A. R. Carvalho2, M. Dinarès i Fernández3, F. Tresserra4, M. A. Zapata1, 2, J. Garcia-Arumi1, 2. 1Retina and Vitreous, Vall d’ Hebron Hospital, Barcelona, Spain; 2Vall d’Hebron Research Institute, Barcelona, Spain; 3 Anatomical Pathology, Vall d’Hebron Hospital, Barcelona, Spain; 4Anatomical Pathology, Instituto Universitario USP Dexeus, Barcelona, Spain; 5 Centro Hospitalar Lisboa Central, Lisboa, Portugal 5805 — D0052 Treatment of Surgically Induced Cystoid Macular Edema by Intravitreal Implant of Dexamethasone. Rino Frisina. Ophthalmology, Sant’Anna Hospital, Brescia, Italy 5806 — D0053 Anatomic and Visual Success after Macular Hole Surgery in an Asian population. Karen Chia, H. Wong. Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore, Singapore 5807 — D0054 Cutter Velocities of Two Vitrectomy Probes: Dual Pneumatic and a Single Pneumatic Drive With Spring Return. Dina Joy K. Abulon. Medical Affairs, Alcon Labs, Irvine, CA *CR 5808 — D0055 Robot assistance for micrometer precision in vitreoretinal surgery. Thijs H. Meenink1, 2, G. Naus1, 2, M. D. de Smet3, 4, M. Beelen1, 2, M. Steinbuch1. 1Mechanical Engineering, Technische Universiteit Eindhoven, Eindhoven, Netherlands; 2PRECEYES Medical Robotics, Eindhoven, Netherlands; 3Ophthalmology, Clinique de Montchoisi, Lausanne, Switzerland; 4Department of Ophthalmology, University of Amsterdam, Amsterdam, Netherlands *CR 5809 — D0056 Results of long-term silicone oil tamponade for more than 12 months and its complications. Yong Sok Ji, H. Jung, K. Yoon, S. Park. Chonnam National University Hospital, Gwangju, Republic of Korea 5810 — D0057 Temporal pattern of macular thickness resolution and visual acuity improvement after epiretinal membrane peel surgeries. Ashley Campbell, D. Vavvas. Ophthalmology, Massachusetts Eye and Ear, Boston, MA *CR Exhibit Hall D0071-D0078 Thursday, May 09, 2013 8:30 AM-10:15 AM Retina 519 Retina-RPE Transplantation Moderators: Robert L. Avery and Susanne Binder 5811 — D0071 iPS-RPE implantation in the Royal College of Surgeons Rat does not lead to adverse events in a long term study of health and graft stability. Stephen Bravo1, P. D. Westenskow1, T. Kurihara1, A. Dorsey1, L. Paris1, J. H. Lin2, M. Friedlander1. 1Department of Cell Biology, The Scripps Research Institute, La Jolla, CA; 2 Department of Pathology, UC San Diego School of Medicine, La Jolla, CA 5812 — D0072 Development of a Novel Device for Subretinal Transplantation Surgery of Human iPSC-RPE Cell-Sheet. Hiroyuki Kamao1, 2, M. Mandai1, O. Mita3, Y. Harada3, J. Kiryu2, M. Takahashi1. 1Laboratory for Retinal Regeneration, Riken Center for Developmental Biology, Kobe, Japan; 2Ophthalmology, Kawasaki Medical School, Okayama, Japan; 3Nidek inc., Gamagori, Japan *CR 5813 — D0073 Three-dimensional imaging of developing photoreceptors transplanted in a mouse model of CEP290-Leber congenital amaurosis (LCA). Yi-Sheng Chang1, 2, R. Fariss2, C. Lin2, J. Nakamura2, W. McIntosh Ambrose2, K. Homma2, R. A. Rachel2, A. V. Cideciyan3, S. G. Jacobson3, A. Swaroop2. 1Department of Ophthalmology, National Cheng Kung University, Tainan City, Taiwan; 2National Eye Institute, National Institutes of Health, Bethesda, MD; 3 Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 5814 — D0074 Retinal Pigment Epithelium - Choroid Transplantation: results up to 3 years. Laura Bertazzi1, A. Peroglio Deiro1, M. G. Cereda2, G. Pertile1. 1Ophthalmology, Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy; 2 Ophthalmology, Ospedale Sacco, Milano, Italy 5815 — D0075 The sodium iodate model for transplantation of hESC-derived RPE. Madalena Carido1, Y. Zhu1, B. Benkner2, T. Kurth1, T. A. Münch2, E. Tanaka1, M. Ader1. 1Center for Regenerative Therapies Dresden, DRESDEN, Germany; 2Werner Reichardt Centre for Integrative Neuroscience, Tubingen, Germany 5816 — D0076 Transplantation of CD73-sorted photoreceptor precursors into the rat retina. Kai Postel, T. Santos-Ferreira, M. Ader. DFG-Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany 5817 — D0077 Cone-like photoreceptor transplantation into the mouse retina. Tiago Santos-Ferreira, K. Postel, M. Ader. AG Ader, DFG-Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 366 Thursday – Posters – 5818 – 5838 5818 — D0078 Development of an ex-vivo retinal explant model to assess transplantation efficiency of photoreceptor progenitor cells. Anat Yanai, C. R. Laver, A. E. Bashar, A. Metcalfe, K. Gregory-Evans. Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada 5823 — D0134 Pigment Migration Distribution in Eyes with Non-neovascular Age-Related Macular Degeneration. Yanling Ouyang1, 2, F. M. Heussen1, 2, A. C. Walsh2, A. M. Joussen1, S. R. Sadda2. 1Ophthalmology, CharitéUniversitätsmedizin Berlin, Berlin, Germany; 2 Ophthalmology, Doheny Eye Institute, Los Angeles, CA *CR 5831 — D0142 Long-term progression, cystoid macular edema and secondary epiretinal membranes in severe chloroquine retinopathy. Simone Kellner1, 2, S. Weinitz1, 2, G. Farmand1, U. Kellner1, 2. 1Rare Retinal Disease Center, AugenZentrum Siegburg, MVZ ADTC Siegburg GmbH, Siegburg, Germany; 2RetinaScience, Bonn, Germany Exhibit Hall D0130-D0184 5824 — D0135 Acute zonal occult outer retinopathy: A new classification based on multimodal imaging. Samira Khan, L. M. Jampol. Ophthalmology, Northwestern Univeristy, Chicago, IL *CR 5832 — D0143 Reading Center Evaluation of Retinal Vein Occlusion Using Wide-field Angiography. Eric Brinton1, A. Domalpally2, B. A. Blodi1, 2. 1Ophthalmology, University of Wisconsin, Madison, WI; 2Ophthalmology, Fundus Photograph Reading Center, Madison, WI Thursday, May 09, 2013 8:30 AM-10:15 AM Retina 520 Imaging II, RE Moderators: Michael D. Abramoff and Stephen H. Tsang 5819 — D0130 The Papillomacular Fold in Posterior Microphthalmos: New Insights Based on Novel Spectral-Domain Optical Coherence Tomography Findings. Sawsan R. Nowilaty1, A. Mousa2, N. G. Ghazi1. 1Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 2Department of Ophthalmology, King Saud University, Riyadh, Saudi Arabia 5820 — D0131 The Use of PolyChromatic Angiography for the Assessment of the Effects of VEGF and Bevacizumab on the Rabbit Retina. Samir R. Tari1, C. Samson2, U. B. Kompella4, R. L. Harris3, C. Lin5, D. A. Antonetti5, G. R. Barile6. 1PCAsso Diagnostics, North Brunswick, NJ; 2New York Eye and Ear Infirmary, New York, NY; 3Rutgers University, New Brunswick, NJ; 4University of Colorado Denver, Denver, CO; 5University of Michigan, Ann Arbor, MI; 6 Manhattan Eye Ear and Throat Hospital, New York, NY *CR 5822 — D0133 Choroidal Thickness in Pseudoxanthoma Elasticum Measured by Enhanced Depth Imaging Optical Coherence Tomography. Martin Gliem, C. K. Brinkmann, F. G. Holz, P. Charbel Issa. Department of Ophthalmology, University of Bonn, Bonn, Germany *CR 5833 — D0144 Characterization of Ultrawidefield Fundus Autofluorescence Patterns in Retinal Dystrophies. George Trichonas, E. I. Traboulsi, J. P. Ehlers. Ophthalmology, Cleveland Clinic, Cleveland, OH *CR 5826 — D0137 Comparison of a widefield Polarization-sensitive OCT with standard imaging of Geographic atrophy. Philipp K. Roberts1, 2, S. Zotter2, B. Baumann2, M. Bolz1, C. G. Kiss1, R. G. Sayegh1, M. Baratsits1, M. Pircher2, C. K. Hitzenberger2, U. Schmidt-Erfurth1. 1 Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria; 2Center for Medical Physics And Biomedical Engineering, Medical University of Vienna, Vienna, Austria *CR 5834 — D0145 The Characterization of Retinal Bestrophinopaties, and Pseudovitelliform Dystrophies using Polarisation Sensitive Optical Coherence Tomography. Gabor Deak1, M. Ritter1, S. Zotter2, P. K. Roberts1, B. Baumann2, M. Pircher2, C. K. Hitzenberger2, U. Schmidt-Erfurth1. 1 Department of Ophthalmology, Medical University of Vienna, Vienna, Austria; 2Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria *CR 5827 — D0138 Detection of Fundus Abnormalities in Diabetic Retinopathy using Spectal Domain OCT versus Mydriatic Color Fundus Imaging. Qing Shao1, Y. Ouyang1, 2, F. M. Heussen1, 2, A. C. Walsh2, A. M. Joussen1, S. R. Sadda2. 1Ophthalmology, Charité-Universitätsmedizin, Berlin, Germany; 2 Ophthalmology, Doheny Eye Institute - USC, Los Angeles, CA *CR 5835 — D0146 Choroidal Thickness after Treatment of Uveal Melanoma with Plaque Brachytherapy. Kavitha R. Sivaraman, C. C. Chow, W. F. Mieler. Department of Ophthalmology, University of Illinois Eye & Ear Infirmary, Chicago, IL *CR 5828 — D0139 Efficacy of NIR and SW-FAF in resolved central serous chorioretinopathy: Detecting outer retinal layer abnormality. Seong-Woo Kim1, J. Oh1, S. Kim1, J. Oh2, C. Yun1, K. Huh1. 1Ophthalmology, Korea University, College of Medicine, Seoul, Republic of Korea; 2 Ophthalmology, Dongguk University, Ilsan Hospital, Goyang, Republic of Korea 5829 — D0140 A Comparison of Heidelberg and Zeiss OCT Imaging in Common Laboratory Animals: Retinal Cell Layer Definition and Correlation to Histopathology. Margaret E. Collins1, W. S. Culp3, K. Tenneson2, S. Wise2, M. Vezina2. 1Toxicology, Charles River, Reno, NV; 2 Ocular and Neuroscience, Charles River, Montreal, QC, Canada; 3Technical Operations, Charles River, Reno, NV *CR 5830 — D0141 Retinal Arteriolar Dilation to Flicker Light is Reduced with Repeated Stimulation. Jonathan E. Noonan1, R. Man1, T. T. Nguyen1, J. Wang1, 2, E. L. Lamoureux1, 3. 1Centre for Eye Research Australia, East Melbourne, VIC, Australia; 2Centre for Vision Research, Sydney, NSW, Australia; 3Singapore Eye Research Institute, Singapore, Singapore 5836 — D0147 Choroidal and Retinal Thickness in Patients Affected by Chronic Posterior Uveitis. Luisa Pierro, M. Gagliardi, E. Miserocchi, L. Iuliano, I. Bianchi, C. Del Turco, G. Parrinello, G. Modorati, M. B. Parodi, F. Bandello. Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy *CR 5837 — D0148 Loss of GCL in HIV positive patients with low (< 100) nadir CD4 counts. Frank D. Verbraak1, 2, N. Demirkaya1, M. D. Abramoff3. 1Ophthalmology, Univ of Amsterdam Acad Med Ctr, Amsterdam, Netherlands; 2 Biomedical Engineering & Physics, Academic Medical Center, Amsterdam, Netherlands; 3 University of Iowa, Iowa City, IA *CR 5838 — D0149 Long-term follow-up of fundus autofluorescence and multi-spectral reflectance imaging using ultra-widefield scanning laser ophthalmoscopy in patients with different retinal pathologies. Viola Graham, M. Fleckenstein, K. Zilkens, S. Schmitz-Valckenberg, F. G. Holz. Department of Ophthalmology, University of Bonn, Bonn, Germany *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 367 Thursday Posters 8:30 am – 10:15 am 5821 — D0132 In-vivo Imaging and Measurement of the Bursa Premacularis using 1,050nm Swept-Source Deep Range Imaging Optical Coherence Tomography (DRI-OCT1 Atlantis®). Silvestro Caputo1, A. Sala-Puigdollers1, H. Jaberansari2, J. Gray1, Y. D’Souza1, S. J. Charles1, S. Biswas1, D. B. Henson1, 3, D. McLeod1, 3 , P. E. Stanga1, 3. 1Vitreoretinal Unit, Manchester Royal Eye Hospital, Manchester, United Kingdom; 2 School of Medicine, University of Manchester, Manchester, United Kingdom; 3Manchester Academic Health Science Centre and Centre for Ophthalmology and Vision Research, Institute of Human Development, University of Manchester, Manchester, United Kingdom *CR 5825 — D0136 Retinal Morphology Changes After Epiretinal Membrane Peeling. Judy E. Kim1, N. R. Mathews1, S. Tarima2. 1Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 2Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI 5839 – 5863 – Thursday – Posters 5839 — D0150 Measuring drusen over time: OCT vs. Fundus Photography. Giovanni Gregori1, C. A. Garcia Filho1, Z. Yehoshua1, R. Portella Nunes1, W. J. Feuer1, S. R. Sadda2, P. J. Rosenfeld1. 1 Ophthalmology, Bascom Palmer Eye Institute, Miami, FL; 2Ophthalmology, Doheny Eye Institute USC, Los Angeles, FL *CR 5840 — D0151 Varicela Zoster virus and Central serous retinopathy. Lukan P. Mishev, A. Misheva, I. Misheva, Y. Cankova, A. Angelov. Ophthalmology, Focus Eye Center, Sofia, Bulgaria 5841 — D0152 Comparison of foveal central thickness in using different spectral-domain OCT machines with manual measurements. Makoto Shirasawa, H. Terasaki, H. Kawano, T. Yamashita, S. Sonoda, T. Sakamoto. Ophthalmology, Kagoshima University, Kagoshima City, Japan 5842 — D0153 Optical coherence tomography features in uveitic macular edema. Breno R. Lima1, S. Mahesh2, H. Sen1. 1National Eye Institute, National Institutes of Health, Bethesda, MD; 2Wills Eye Institute, Philadelphia, PA 5843 — D0154 Posterior Eye Wall Radius of Curvature as a Measure of Staphyloma Progression in Myopic Foveoschisis Patients as Gauged by Optical Coherence Tomography. Pamela Sherwood1, J. Leong1, S. Chang1, G. C. Cheung2, Q. V. Hoang1. 1Ophthalmology, Columbia University Medical Center, New York, NY; 2Singapore National Eye Centre, Singapore, Singapore *CR 5844 — D0155 Evaluation of the Digital Light Projector Camera (DLP-Cam) for Low-Cost Diabetic Retinopathy Screening. Taras V. Litvin1, G. Y. Ozawa1, J. A. Cuadros1, M. S. Muller3, A. E. Elsner2, 3, T. Gast3, J. Clendenon3, L. Ensman2, T. Roy1, D. Li1. 1School of Optometry, UC Berkeley, Berkeley, CA; 2School of Optometry, Indiana University, Bloomington, IN; 3Aeon Imaging, LLC, Bloomington, IN *CR Thursday Posters 8:30 am – 10:15 am 5845 — D0156 Ultra-widefield retinal imaging documentation and analysis of peripheral retinal disease in Marfan syndrome: From the Marfan Eye Consortium of Chicago. Safa Rahmani1, 2, A. A. Fawzi1, A. T. Lyon1, 2, I. H. Maumenee3, M. Mets2. 1Northwestern University, Chicago, IL; 2 Lurie Children’s Hospital of Chicago, Chicago, IL; 3 Univeristy of Illinois at Chicago, Chicago, IL 5846 — D0157 Intravitreal Injection of Bevacizumab for Macula Edema Secondary to Central Retinal Vein Occlusion: Efficacy at 1 Day after Injection. Atsushi Ishikawa, Y. Imamura, M. Mita-Takahashi, R. Higashida, Y. Tsutsumi, Y. Ichikawa, M. Ishida. Teikyo University, Kawasaki, Japan 5847 — D0158 Fundus Autofluorescence of Exudative Age-Related Macular Degeneration with Intraretinal Cystoid Lesion. Tetsuya Yamagishi1, H. Koizumi2, T. Yamazaki1, N. Terao1, K. Nakayama1, S. Kinoshita1. 1Department of Ophthalmology, Kyoto Prefectural Univ of Med, Kyoto, Japan; 2Department of Ophthalmology, Tokyo Women’s Medical University, Tokyo, Japan *CR 5848 — D0159 Retinal vascular abnormalities in the far periphery of pathologic myopic eyes imaged by ultra wide-field fluorescein angiography. Yuichiro Kaneko1, M. Moriyama1, N. Shimada1, N. Nagaoka1, K. Shinohara1, Y. Tanaka1, K. Ohno-Matsui1, T. Tokoro1, S. Hirahara2, Y. Ogura2. 1Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Bunkyo-ku, Japan; 2 Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Scinences, Nagoya, Japan 5849 — D0160 Retinal-choroidal changes after loading phase of ranibizumab in diabetic macular edema. Paola Giorno, M. Parravano, A. Cacciamani, F. Oddone, F. Scarinci, A. Boninfante, M. Varano. Ophthalmology, Fondazione G.B. Bietti-IRCCS, Rome, Italy 5850 — D0161 Refractive Impact on the Espion Multifocal ERG in Clinical Practice. John Hamilton, A. M. Theogene, R. Munger, S. G. Coupland. Ophthalmology, University of Ottawa Eye Institute, Ottawa, ON, Canada *CR 5851 — D0162 Macular and Optic Nerve Optical Coherence Tomography in Marfan Patients: from the Marfan Eye Consortium of Chicago. WanWan Xu1, S. Kurup2, A. A. Fawzi1, M. K. Durbin4, I. H. Maumenee3, M. Mets2, 1. 1 Ophthalmology, Northwestern University, Chicago, IL; 2Ophthalmology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL; 3 Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL; 4Carl Zeiss Meditec, Inc, Dublin, CA *CR 5852 — D0163 Multimodal imaging in Persistent Placoid Maculopathy. Mohamed G. Gendy1, A. A. Fawzi1, R. T. Wendel2, D. J. Pieramici3, J. A. Miller4, D. M. Brown5, L. M. Jampol1. 1Ophthalmology, Northwestern University, Chicago, IL; 2Retina Consultants, Sacramento, CA; 3 California Retina Consultants, Bakersfield, CA; 4 Retina Consultants of Michigan, Southfield, MI; 5 Retina Consultants of Houston, Houston, TX *CR 5853 — D0164 Novel angiographic findings in Susac syndrome identified by ultra-widefield imaging technology. Priyanka Kumar, R. J. Courtney, K. Baynes, C. Y. Lowder, J. P. Ehlers, R. Rennebohm, S. K. Srivastava. Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH *CR 5854 — D0165 Development of a Premacular Vitreous Pocket. Tadashi Yokoi, N. Azuma. Ophthalmology, National Center for Child Health and Development, Tokyo, Japan 5855 — D0166 Evaluation of subfoveal choroidal thickness before and after cataract surgery. Minoru Tanigawa, Y. Shimada, Y. Ochiai, H. Ochiai, Y. Tsukahara, H. Yamanaka. ShinNagata Eye Institute, Kobe, Japan 5856 — D0167 Classification and Quantitative Analysis of Geographic Atrophy Lesions Using Spectral-Domain Optical Coherence Tomography. Jinfeng Qu1, 2, M. Nittala2, A. Hariri2, D. M. Wu2, S. Sadda2. 1Ophthalmology, People’s Hospital of Peking University, Beijing, China; 2 Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA *CR 5857 — D0168 Spectral-Domain Optical Coherence Tomography Findings of Eyes With Idiopathic Macular Telangiectasia. Mounir Benzerroug, S. Molva, D. Bremond-Gignac, S. Milazzo. Ophthalmology, Amiens University Hospital, Amiens, France 5858 — D0169 Assessing IOLMaster Measurement of Eye Axial Length in Pathologic Myopia Patients with Staphyloma. Jamie Leong, R. H. Silverman, S. Chang, Q. V. Hoang. Ophthalmology, Columbia University, New York, NY *CR 5859 — D0170 Is the Integrity of the Photoreceptor Layer A Prognostic Factor for Visual Acuity Gain in Thick Macular Puckers? Aranzazu Mateo Montoya1, B. Wolff1, V. Martinet1, P. Cornut2, J. A. Sahel1. 1Retina, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France; 2Hôpital Edouard Herriot, Lyon, France *CR 5860 — D0171 Cyst Size Does Not Predict Response to Therapy on OCT Imaging of Macular Edema. Gautam Kamthan, R. M. Lieberman. Mount Sinai School of Medicine, New York, NY 5861 — D0172 Photoreceptor Changes on Multi-Modal Adaptive-Optics Imaging Correlate with Transient Abnormalities on Autofluorescence and Indocyanine Green Angiography in a Patient with Multiple Evanescent White Dot Syndrome. John E. Legarreta1, A. D. Legarreta1, 2, Z. Nadler1, L. T. Labriola1. 1Ophthalmology, UPMC Eye Center/ University of Pittsburgh, Pittsburgh, PA; 2Duke University, Durham, NC 5862 — D0173 Unique Features of Choroidal Vasculature In Patients with Choroidal Neovascular Membranes. Swetangi D. Bhaleeya, D. J. D’Amico, S. Kiss. Ophthalmology, Weill Cornell Medical Center, New York City, NY *CR 5863 — D0174 Choroidal thickness after treatment of chronic central serous chorioretinopathy: half-fluence photodynamic therapy versus intravitreal injection of bevacizumab. Yong Un Shin, B. Lee, D. Lee. Ophthalmology, Hanyang University Medical Center, Seoul, Republic of Korea *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 368 Thursday – Posters – 5864 – 5887 5864 — D0175 Steroid-associated central serous chorioretinopathy, multidisciplinary imaging. Byung Ro Lee, Y. Shin, S. Lee. Ophthalmology, Hanyang Univ Hosp, Seoul, Republic of Korea *CR 5872 — D0183 Ultra-wide field fluorescein angiography in patients with diabetic retinopathy. Taneto Tomiyasu, S. Hirahara, M. Yoshida, M. Nozaki, Y. Ogura. Opthalmology, Nagoya City Univ Medical School, Nagoya, Japan 5865 — D0176 Progression of Atrophy of the Retinal Pigment Epithelium in Stargardt Macular Dystrophy on Fundus Autofluorescence Imaging. Emily Fletcher1, 2, Y. Wolfson1, B. E. Munoz1, H. P. Scholl1, 3. 1Ophthalmology, Johns Hopkins University, Baltimore, MD; 2Retina Division, Gloucester Royal Hospital, Gloucester, United Kingdom; 3Ophthalmology, Medical University Graz, Graz, Austria 5873 — D0184 Repeatability and Reproducibility of Spectral-domain Optical Coherence Tomography in Measurement of Retinal Thickness in Rats. TaeGi Kim, J. Yang, J. Han, S. Yu, H. Kwak. Ophthalmology, Kyung Hee University Hospital, Seoul, Republic of Korea 5866 — D0177 Macular Choroidal Thickness Evaluation By SD OCT In Patients Affected By Retinal Vein Occlusion. Davide Borroni, E. Melardi, C. Gandolfi, M. Al Oum, S. Donati, M. Chiaravalli, C. Azzolini. Department of Surgical and Morphological Sciences, University of Insubria-Circolo Hospital, Varese, Italy Thursday, May 09, 2013 8:30 AM-10:15 AM 5867 — D0178 The Dissociation Between the Ganglion Cell Analysis/Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer Thickness in Hereditary Retinal Disease. Sherry J. Bass, A. Wong, J. Sherman. Clinical Sciences, SUNY College of Optometry, New York, NY *CR 5868 — D0179 Myopia Progression Accompanying with Myopic Disc Change at the Convalescent Stage of Vogt-Koyanagi-Harada Disease. Hiroyuki Takahashi, H. Takase, N. Shimada, K. Ohno-Matsui, M. Mochizuki. Ophthal & Visual Science, Tokyo Medical and Dental Univ, Bukyo-ku, Japan *CR 5869 — D0180 Novel and safe technique for smartphone fundus photography: Application in human and animal eyes. Luis J. Haddock1, D. Kim1, F. C. Delori2, S. Mukai1. 1Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA; 2 Ophthalmology, Schepens Eye Research Institute, Boston, MA 5870 — D0181 Comparing Optos OTI and Heidelberg Spectralis SD-OCT in Patients with Diabetic Macular Edema. Samia Fatum, M. Sinczak, A. Sachdev, V. Chong. Ophthalmology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom *CR Anatomy/Pathology 521 Ocular and Orbital Tumors Moderators: Seymour Brownstein and Valerie A. White 5874 — D0237 Malignant Cancer After Trauma or Presumed Trauma in Cats. Richard R. Dubielzig. Pathobiol Sciences, Univ of WisconsinMadison, Madison, WI *CR 5875 — D0238 Canine Primary Ocular Osteosarcomas and Chondrosarcomas. Felicia D. Duke, R. R. Dubielzig. Pathobiological Sciences, University of Wisconsin, Madison, WI *CR 5876 — D0239 AJCC TNM Collaborative Internet Staging Validation For Ophthalmic Tumors. Priya Selvakumar. 1The Ophthalmic Oncology Task Force, American Joint Committee on Cancer, Chicago, IL; 2Health Informatics Research, Princess Margaret Cancer Centre, Toronto, ON, Canada 5877 — D0240 Prognostic Factors Associated with Histopathology in Intraocular and Ocular Adnexal Lymphoma: A Twenty Years Review for the University of Wisconsin Madison. Pimkwan Jaru-ampornpan1, A. Azari1, M. Rezaei Kanavi1, 2, H. Potter1, D. M. Albert1. 1Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Madison, WI; 2Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran 5878 — D0241 Uveal Lymphoma: Comparison of Diagnostic Imaging Studies. Mary E. Aronow1, C. Portell2, J. Sweetenham2, A. D. Singh1. 1Cole Eye Institute, Cleveland Clinic, Shaker Heights, OH; 2Hematologic Oncology and Blood Disorders, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH 5880 — D0243 The Usefulness of Cell Block Technique in Cytological diagnosis of Primary Intraocular Lymphoma. Takako Ito1, H. Yoshikawa1, A. Takeda1, T. Yoshimura1, S. Hirakawa1, K. Sonoda2, T. Koga3, T. Ishibashi1. 1 Ophthalmology, Kyushu University, Fukuoka, Japan; 2Ophthalmology, Yamaguchi University, Yamaguchi, Japan; 3Pathology, Kyushu University, Fukuoka, Japan 5881 — D0244 Distinct Profiles of Vitreous micro RNA in Primary Vitreoretinal Lymphoma and Uveitis. Jingsheng Tuo, D. Shen, C. Chan. Laboratory of Immunology, National Eye Institute/ NIH, Rockville, MD 5882 — D0245 Using a Murine Xenograft Model for Von Hippel-Lindau Disease-Associated Retinal Hemangioblastomas to Test Novel Therapies. Stanley Park1, 2, Y. Wang1, K. Huntoon3, D. Shen1, Z. Zhuang3, C. Chan1. 1Immunopathology Section, Laboratory of Immunology, NEI, NIH, Bethesda, MD; 2Howard Hughes Medical Institute, Chevy Chase, MD; 3Surgical Branch, NINDS, NIH, Bethesda, MD 5883 — D0246 Transvitreal endoresection of retinal hemangioblastoma after ligating feeder vessels. Gibran S. Khurshid. Ophthal & Visual Sci, Univ of Texas Medical Branch, Galveston, TX 5884 — D0247 Prognostic Factors after Treatment of Patients with Retinal Capillary Hemangioma(RCH). Hyesun Kim, J. Yi, H. Kwon, C. S. Lee, S. lee. Department of Ophthalmology, Yonsei University Severance Hospital, Seoul, Republic of Korea 5885 — D0248 Safety and Efficacy of Anti-VEGF Therapy for Choroidal Neovascularization Overlying Choroidal Osteoma. Mohammed A. Khan1, F. C. DeCroos2, P. P. Storey2, J. Shields3, S. J. Garg2, C. L. Shields3. 1 Ophthalmology, Wills Eye Institute, Philadelphia, PA; 2Retina Service, Wills Eye Institute, Philadelphia, PA; 3Oncology Service, Wills Eye Institute, Philadelphia, PA *CR 5886 — D0249 Effect of menopausal status on the progression of orbital cavernous hemangiomas. Anupam Jayaram, G. Lissner. Ophthalmology, Northwestern University, Chicago, IL 5887 — D0250 The effect of Transforming growth factor-beta-induced protein (TGFBIp) in lymphangiogenesis. Yong-Sun Maeng, T. Kim, H. Lee, E. Kim. Ophthalmology, Yonsei University, Seoul, Republic of Korea f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 369 Thursday Posters 8:30 am – 10:15 am 5871 — D0182 Improving the Analysis of Choroidal Laser Doppler Flowmetry Measurements; Application in Patients with Retinal Diseases. Nattapon Boonarpha1, 2, G. Czanner1, 3, A. Raj1, 2, Y. Zheng1, 2, M. Geiser4, C. E. Riva5, J. Sahni1, 2, S. P. Harding1, 2. 1Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom; 2St. Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom; 3Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom; 4University of Applied Sciences of Western Switzerland, Sion, Switzerland; 5Medical School, University of Lausanne, Lausanne, Switzerland *CR Exhibit Hall D0237-D0262 5879 — D0242 Clinical and epidemiologyc features of lymphoproliferative lesions in the orbital and adnexal region at the Asociación Para Evitar la Ceguera en México. Linda Guakil1, G. Salcedo1, A. A. Rodríguez-Reyes2, R. Rubio1. 1 Orbit and Oculoplastics, Asociacion Para Evitar La Ceguera En Mexico, Mexico, Mexico; 2Pathology, Asociacion Para Evitar La Ceguera En Mexico, Mexico, Mexico 5888 – 5905 – Thursday – Posters 5888 — D0251 RAS Mutations Coexist with PIK3CA and MET Mutations in Lacrimal Gland Epithelial Neoplasms. Bita Esmaeli1, V. T. Yin1, K. Wani2, K. Aldape2, D. Bell2. 1Head & Neck Surgery/Ophthal, UT MD Anderson Cancer Center, Houston, TX; 2Pathology, UT MD Anderson Cancer Center, Houston, TX 5889 — D0252 Screening of Optic Pathway Gliomas in Children with Neurofibromatosis Type-1. Raffaele Parrozzani1, M. Clementi2, G. Orlando3, G. Miglionico3, E. Trevisson2, E. Midena3, 1. 1GB Bietti Eye Foundation, IRCCS, Rome, Italy; 2Department of Pediatrics, Clinical Genetics, University of Padova, Padova, Italy; 3 Department of Ophthalmology, University of Padova, Padova, Italy 5890 — D0253 Association of AJCC pT category with outcome in sebaceous carcinoma of the eyelid. Valerie A. White1, 2, K. Mulay3, S. Agrawal4, S. Honavar4. 1Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; 2 Ophthalmology and Visual Science, University of British Columbia, Vancouver, BC, Canada; 3 Ophthalmic Pathology, LV Prasad Eye Institute, Hyderabad, India; 4Oculoplastic and Orbital Surgery, LV Prasad Eye Institute, Hyderabad, India 5891 — D0254 Stratifin- A novel biomarker in the prognosis of Ocular Surface Squamous Neoplasia patients. Sheetal Chauhan1, S. Sen1, A. Sharma2, S. Kashyap1, S. S. Chauhan3, R. Tandon4, N. Pushker4, M. Vanathi4, R. Azad4. 1Ocular Pathology, R.P.Centre, All India Institute of Medical Sciences, New Delhi, India; 2Ocular Microbiology, All India Institute of Medical Sciences, New Delhi, India; 3Biochemistry, All India Institute of Medical Sciences, New Delhi, India; 4Ophthalmology, All India Institute of Medical Sciences, New Delhi, India Thursday Posters 8:30 am – 10:15 am 5892 — D0255 Incidence and immunostaining pattern of oncocytomas of the caruncle - a single center 12 year analysis. Sandra C. Bajorat1, M. von Schoenfels1, I. Leuschner2, J. Roider1, S. O. Koinzer1. 1Ophthalmology, University of Kiel, University Medical Center, Kiel, Germany; 2 Pathology, University of Kiel, University Medical Center, Kiel, Germany *CR 5893 — D0256 Classification Schemes for Conjunctival Melanocytic Neoplasia: the Effect of Immunohistochemistry on C-MIN Scoring. Emilia H. DeMarchis1, P. Egbert2, J. Kim3, 4. 1School of Medicine, Stanford University, Palo Alto, CA; 2Department of Ophthalmology, Stanford University, Stanford, CA; 3Department of Pathology, Stanford University, Stanford, CA; 4 Department of Dermatology, Stanford University, Stanford, CA 5894 — D0257 Immunohistochemical Analysis with a Novel Red Chromagen of Benign and Malignant Melanocytic Lesions of the Conjunctiva. Seymour Brownstein1, 2, K. Jiang1, 2, K. Lam1, 2, B. F. Burns2, J. Farmer2. 1 Ophthalmology, Ottawa Hospital, Ottawa, ON, Canada; 2Pathology, Ottawa Hospital, Ottawa, ON, Canada 5895 — D0258 Conjunctival Nevus: Clinicopathological Review of 724 cases. Stephanie De la O-Pérez1, H. A. RodríguezMartínez2, D. Ríos y Valles-Valles1, O. PérezOlvera2, A. Gómez-Leal1, A. Medina-Cruz2, M. Y. Namba-Bando1, L. H. De La O-Cerna3, A. A. Rodríguez-Reyes1. 1Ophthalmic Pathology Service, Hospital “Dr. Luis Sánchez Bulnes”, Asociación Para Evitar la Ceguera en México, Mexico city, Mexico; 2Anatomopathological Research Laboratory “Roberto Ruiz Obregón” Experimental Medicine Department, Medical Faculty, National Autonomous University of Mexico, General Hospital of Mexico, Mexico City, Mexico; 3Eye Bank, University Hospital, Autonomous University of Coahuila, Torreón, Mexico 5896 — D0259 The Growth of Small Choroidal Melanocytic Lesion after Intravitreal Bevacizumab Injection. Hee Jung Kwon, H. Kang, H. Kim, S. Lee, C. S. Lee. Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea 5897 — D0260 Clinical utility of SD-OCT -Enhanced Depth Imaging in Evaluation of Retinal and Choroidal Tumors of the Human Eye. Peter G. Hovland. Colorado Retina Associates, Denver, CO 5898 — D0261 Waardenburg Syndrome: Iris and Choroidal Hypopigmentation findings on Anterior and Posterior Segment Imaging. Stephanie Nickerson, C. L. Shields, S. AL-Dahmash, J. Shields. Ocular Oncology Service, Wills Eye Institute, Philadelphia, PA 5899 — D0262 Does beta-ray emitting therapy of ciliary body tumors decrease central corneal endothelial cell density? Eva Suranyi1, A. Berta2, L. Modis3, E. Szalai4, J. Damjanovich5. 1 Ophthalmology, University of Debrecen, Debrecen, Hungary; 2Ophthalmology, University of Debrecen, Debrecen, Hungary; 3Ophthalmology, University of Debrecen, Debrecen, Hungary; 4Ophthalmology, University of Debrecen, Debrecen, Hungary; 5 Ophthalmology, University of Debrecen, Debrecen, Hungary Exhibit Hall D0263-D0276 Thursday, May 09, 2013 8:30 AM-10:15 AM Eye Movements / Strabismus / Amblyopia / Neuro-Ophthalmology 522 Thyroid Eye Disease Moderator: Huibert J. Simonsz 5900 — D0263 Signal intensity measurement of magnetic resonance imaging for extraocular muscles inflammation in thyroidassociated ophthalmopathy before and after methylprednisolone pulse therapy. Tomoaki Higashiyama, Y. Nishida, Y. Ichiyama, S. Muraki, M. Ohji. Ophthalmology, Shiga University of Medical Science, Otsu, Japan *CR 5901 — D0264 Subclinical alterations of extraocular muscles in Graves’ Disease. Alberto Cuccu1, I. Zucca1, M. Galantuomo1, S. Mariotti2, F. Boi2, R. Vacca2, M. Fossarello1. 1Ophthalmology, University of Cagliari, Cagliari, Italy; 2Medical Science, University of Cagliari, Cagliari, Italy 5902 — D0265 Medical Histories and Ophthalmic Features, including Orbital Images of MRI, in Patients with Dysthyroid Optic Neuropathy. Ai Kozaki, T. Inoue, C. Funaki, K. Mizuno, R. Inoue, Y. Inoue. Ophthalmology, Olympia Eye Hospital, Tokyo, Japan 5903 — D0266 Protocol for Protein Isolation from Human Orbital Fat Tissue: Use for Western Blots and Antigen Biomarker Identification in Thyroid Eye Disease. Katie Mills1, M. Z. Radic2, I. Neeli2, M. E. Phillips1, C. Cutler Peck1, B. N. Wilkes1, J. C. Fleming1, A. Iannaccone1, N. C. Kerr1. 1Ophthalmology, Hamilton Eye Institute, Memphis, TN; 2Molecular Science, University of TN, Memphis, TN 5904 — D0267 Palmitate induced secretion of IL-6 and MCP-1 in orbital fibroblasts derived from patients with thyroid-associated ophthalmopathy. Ji-Sun Paik1, W. Cho2, E. Oh3, 4 , S. Lee3, 4, S. Yang1. 1Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of Korea; 2 Ophthalmology and Visual Science, DaeJeon St. Mary’s Hospital, the Catholic University of Korea, Seoul, Republic of Korea; 3Institue of Hansen’s Disease, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea; 4 Pathology, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea 5905 — D0268 Treatment of Esotropia from Thyroid Eye Disease by Lateral Rectus Resection. Daniel Greninger, P. H. Berg, E. A. Steele. Ophthalmology, Oregon Health and Science University, Portland, OR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 370 Thursday – Posters – 5906 – 5913 5906 — D0269 Lower Social Grade and Higher Social Deprivation are Independently Associated with Severe Thyroid Eye Disease. Matthew R. Edmunds1, 2, J. A. Huntbach2, O. M. Durrani2. 1 Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom; 2 Birmingham & Midland Eye Centre, Birmingham, United Kingdom 5913 — D0276 Posterior conjunctival plication to correct secondary ptosis after eyelid retraction repair in Graves disease. Vinita Srivastava1, H. R. Patel1, H. A. Shah1, 2, H. H. Lee1, 2, W. R. Nunery1, 3. 1 Dept of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2Oculofacial Plastic and Orbital surgery, Indianapolis, IN; 3Oculofacial Plastic and Orbital surgery, Louisville, KY 5907 — D0270 Rapamycin enhances the TNF-α-induced secretion of IL-6 and IL-8 by suppressing PDCD4 degradation in orbital fibroblasts. Won-Mo Lee1, J. Won2, J. Paik2, W. Cho2, E. Oh3, 4, S. Lee3, 4, S. Yang2. 1SeongMo Eye Clinic, Dae Jeon, Republic of Korea; 2 Ophthalmology and Visual Science, the Catholic University of Korea, Seoul, Republic of Korea; 3 Institute of Hansen’s Disease, The Catholic University of Korea, Seoul, Republic of Korea; 4 Department of Pathology, The Catholic University of Korea, Seoul, Republic of Korea 5908 — D0271 Readability Assessment of Online Thyroid Eye Disease Patient Information. Alastair K. Denniston1, 2, M. R. Edmunds1, 2. 1 Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom; 2 University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom 5909 — D0272 Clinical and Biochemical Characteristics of Thyroid-Associated Ophthalmopathy in Korean Populations using VISA and Fat/Muscle Typing. Young Ji Lee1, S. Lee1, H. Lew2, J. Yoon1. 1Institute of Vision Research, Department of Ophthalmology, Yonsei University College Of Medicine, Seoul, Republic of Korea; 2Department of Ophthalmology, CHA University, Bundang CHA Medical Center, Sungnam, Republic of Korea 5910 — D0273 Clinical Features of Japanese Elderly Patients with Dysthyroid Ophthalmopathy. Kahori Mizuno, A. Kozaki, C. Funaki, G. Ito, R. Inoue, K. Nishiyama, T. Inoue, Y. Inoue. Ophthalmology, Olympia Eye Hospital, Tokyo, Japan 5911 — D0274 Thyroid Eye Disease With Compressive Optic Neuropathy: Decompression Versus Radiation. Sheila Goyal, M. A. Slabaugh, S. Chang. Ophthalmology, University of Washington, Seattle, WA Thursday Posters 8:30 am – 10:15 am 5912 — D0275 Expression of GRα mRNA and NF-kB in orbital fat and extraocular muscle in Thyroid Eye Disease. Ivana L. RomeroKusabara1, 3, A. N. Cury2, 3, J. Vital Filho1, N. M. Scalissi2, K. C. Melo3, G. Demartino3, C. A. Longui2, 3 , M. R. Melo3. 1Ophthalmology, Santa Casa of Sao Paulo, Sao Paulo, Brazil; 2Endocrinology, Santa Casa of Sao Paulo, Sao Paulo, Brazil; 3Molecular Medicine Laboratoty, Physiology, Santa Casa of Sao Paulo, Sao Paulo, Brazil f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 371 5914 – 5929 – Thursday – Papers/Minisymposium 6B Thursday, May 09, 2013 10:30 AM-12:15 PM Glaucoma 523 Structure/Function Moderator: Claude F. Burgoyne 5914 — 10:30 Relationships among Visual Cortex Metabolism, Retinal Morphology and Visual Function in Early and Advanced Glaucoma. Kevin C. Chan1, 2, I. P. Conner1, Z. Safiullah2, S. Kim3, 2, G. Wollstein1, J. S. Schuman1, 2. 1 UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA; 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA; 3Department of Radiology, University of Pittsburgh, Pittsburgh, PA *CR 5915 — 10:45 The relationship between cup/ disc ratio and estimated number of retinal ganglion cells. Andrew J. Tatham1, R. N. Weinreb1, L. M. Zangwill1, J. M. Liebmann2, C. A. Girkin3, F. A. Medeiros1. 1Hamilton Glaucoma Center, University California San Diego, La Jolla, CA; 2 Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY; 3Department of Ophthalmology, University of Alabama, Birmingham, AL *CR, f Thursday Papers/ Minisymposium 10:30 am – 12:15 pm 5916 — 11:00 Machine Classifier Clustering of Ocular Structure Measurements Poorly Corresponds with Longitudinal Functional Performance in Glaucoma. Jessica E. Nevins1, D. Danks2, 3, G. Wollstein1, H. Ishikawa1, 4, L. Kagemann1, 4, I. A. Sigal1, 4, J. S. Schuman1, 4. 1 UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA; 2Department of Philosophy, Carnegie Mellon University, Pittsburgh, PA; 3Institute for Human & Machine Cognition, Pensacola, FL; 4Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA *CR 5917 — 11:15 Posterior Lamina Cribrosa Displacement at Different Stages of Glaucoma. Sung Chul Park1, 2, R. L. Furlanetto1, C. F. Netto1, Y. Liu1, 3, Y. Kung1, 3, S. Fernando-Sieminski4, J. M. Liebmann1, 5, R. Ritch1, 2. 1Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY; 2Department of Ophthalmology, New York Medical College, Valhalla, NY; 3New York Medical College, New York, NY; 4Ross Eye Institute, State University of New York at Buffalo, Buffalo, NY; 5Department of Ophthalmology, New York University School of Medicine, New York, NY *CR 5918 — 11:30 Relating retinal ganglion cell (RGC) function and retinal nerve fiber layer (RNFL) retardance to progressive loss of RNFL thickness (RNFLT). Brad Fortune, G. Cull, J. Reynaud, C. F. Burgoyne. Discoveries in Sight Research Laboratories, Devers Eye Institute and Legacy Research Institute, Legacy Health, Portland, OR *CR 5919 — 11:45 Why ISNT Rim Area Greater for Superior Optic Disc? William H. Swanson1, V. Malinovsky1, M. W. Dul2. 1School of Optometry, Indiana University, Bloomington, IN; 2SUNY College of Optometry, State University of New York, New York, NY 5920 — 12:00 Retinal venous pulsatility is reduced in regions of nerve fibre layer loss in glaucoma. Mojtaba Golzan1, W. Morgan2, S. Graham1. 1Macquarie University, Sydney, NSW, Australia; 2Lions Eye Institute, University of Western Australia, Perth, NSW, Australia 6C Thursday, May 09, 2013 10:30 AM-12:15 PM Retina 524 Imaging: Diagnostic and Function Moderators: Timothy W. Olsen and David J. Wilson 5921 — 10:30 SD-OCT Progressive Alterations in a Family Affected with Müller Cell Sheen Dystrophy. Valentina Franco-Cardenas, J. DalmaWeiszhausz, R. E. Martinez-Munoz, A. Dalma. Retina, Asociacion para Evitar la Ceguera en Mexico, Mexico City, Mexico 5922 — 10:45 Outer Retina Analysis by Optical Coherence Tomography in Cone-Rod Dystrophy Patients. Luiz H. Lima1, J. M. Sallum1, R. F. Spaide2. 1Ophthalmology, Federal Unive of Sao Paulo-UNIFESP, Sao Paulo, Brazil; 2Vitreous, Retina, Macula Consultants of New York, New York, NY *CR 5923 — 11:00 Atypical findings in Spectral Domain Optical Coherence Tomography of Ocular Toxoplasmosis with Active Lesions. Florian M. Heussen, Y. Ouyang, Q. Shao, A. M. Joussen, U. Pleyer. Ophthalmology, Charite University Medicine Berlin, Berlin, Germany *CR 5924 — 11:15 Short-term Spectral Domain Optical Coherence Tomography Changes after Phacoemulsification in Eyes with No Pre-operative Macular Pathology. Yulia Wolfson, W. Stark, S. B. Bressler, N. M. Bressler. Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD *CR 5925 — 11:30 Macular vascular development assessed by fluorescein angiography in premature newborn patients with retinopathy of prematurity. Alberto Hernandez-Vargas, G. Salcedo-Villanueva, R. Romero Vera, S. Salinas Longoria, F. Schoonewolff, V. Morales-Canton, J. J. Fromow-Guerra, M. A. Martinez-Castellanos. Assoc Para Evitar la Ceguera en Mexico, IAP, Mexico, Mexico *CR 5926 — 11:45 Three-year multimodal imaging and predictive value of retinal nerve fiber layer axoplasmic debris in branch retinal vein occlusion. Marion R. Munk1, S. Sacu1, R. Dunavoelgyi1, M. Baratsits1, A. Montuoro2, G. Matt1, C. G. Kiss1, W. Buehl1, U. Schmidt-Erfurth1. 1 Dept of Ophthalmology, Medical University Vienna, Vienna, Austria; 2Vienna Reading Center, Medical University Vienna, Vienna, Austria *CR 5927 — 12:00 Assessment of the inner segment/ outer segment layer in patients with macular edema due to central retinal vein occlusion. Barbara A. Blodi, S. Chen, Y. Huang, J. W. Pak, A. Domalpally. Department of Ophthalmology and Visual Science, University of Wisconsin, Madison, WI *CR 606/607 Thursday, May 09, 2013 10:30 AM-12:15 PM Immunology/Microbiology 525 Clinical and Translational Studies in Ocular Inflammation Moderators: Andrew D. Dick and Justine R. Smith 5928 — 10:30 Targeted B-cell Therapy with Rituximab for the Treatment of Autoimmune Retinopathy: Results of a Pilot Clinical Trial. H Nida Sen1, M. D. Dalal1, L. Grange1, Y. Wang1, J. R. Heckenlively2, P. R. Sherry1, C. Chan1, R. B. Nussenblatt1. 1National Eye Institute, National Institutes of Health, Bethesda, MD; 2Kellogg Eye Center, University of Michigan, Ann Arbor, MI f 5929 — 10:45 IV Secukinumab Is An Effective Treatment In Patients With Noninfectious Uveitis Requiring Steroid Sparing Immunosuppressive Therapy. Erik Letko1, S. Yeh2, C. L. Grosskreutz3, U. Pleyer4, C. Foster5, M. G. Brigell6. 1Corneal Consultants of Colorado, Denver, CO; 2 Ophthalmology Eye Center, Atlanta, GA; 3Global Translational Medicine Head for Ophthalmology Novartis Institutes for Biomedical Research, Cambridge, MA; 4Ophthalmology University Charite Berlin, Berlin, Germany; 5Ophthalmology Ocular Immunol & Uveitis Foundation, Cambridge, MA; 6Novartis Institutes for BioMedical Research, Inc., Cambridge, MA *CR, f The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 372 Thursday – Papers/Minisymposium – 5930 – 5944 5930 — 11:00 Clinical Characteristics and Treatment Outcomes of Juvenile Idiopathic Arthritis Associated Uveitis. Nisha Acharya1, 2, S. Patel3, G. Homayounfar1, W. Enanoria1, 2, A. Shakoor1, A. Chakrabarti3, D. A. Goldstein3, 4. 1 F.I. Proctor Foundation, University of California, San Francisco, San Francisco, CA; 2Department of Ophthalmology, University of California, San Francisco, San Francisco, CA; 3Department of Ophthalmology, University of Illinois College of Medicine at Chicago, Chicago, IL; 4Department of Ophthalmology, Northwestern Memorial Feinberg School of Medicine, Chicago, IL *CR 5931 — 11:15 12-Month Results of the SAVE Study - Sirolimus as Therapeutic Approach to UVEitis: A Randomized Study to Assess the Safety and Bioactivity of Intravitreal and Subconjunctival Injections of Sirolimus in Patients with Non-infectious Uveitis. Quan Dong Nguyen1, 2, M. A. Ibrahim2, A. L. Watters2, Y. J. Sepah2, M. G. Bittencourt2, J. Yohannan2, J. Naor3, N. K. Shams3, D. V. Do2. 1Diseases of the Retina & Uveitis, Johns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD; 2Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD; 3Santen, Inc, Emeryville, CA *CR, f 5932 — 11:30 The Course of Uveitis in Pregnancy and the Postpartum. Lyndell Lim1, 5, N. Chiam1, R. J. Stawell3, 4, L. Busija1, A. J. Hall2, 3. 1 Centre for Eye Research Australia, University of Melbourne, East Melbourne, VIC, Australia; 2 Ophthalmology, The Alfred Hospital, Melbourne, VIC, Australia; 3Eye Surgery Associates, Melbourne, VIC, Australia; 4Ocular Immunology Clinic, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia; 5Victoria Parade Eye Consultants, East Melbourne, VIC, Australia *CR 5933 — 11:45 Visual outcomes in uveitis with angiographic macular leakage treated with the fluocinolone acetonide implant or standard treatment. Thomas A. Albini1, D. A. Goldstein2, D. Callanan3, Q. Nguyen4, S. K. Srivastava5. 1 Ophthalmology, Bascom Palmer Eye Institute, Miami, FL; 2Ophthalmology, Northwestern Universty, Chicago, IL; 3Ophthalmology, Texas Retina Associates, Dallas, TX; 4Ophthalmology, Johns Hopkins University, Baltimore, MD; 5 Ophthalmology, Cleveland Clinic, Cleveland, OH *CR, f 5934 — 12:00 Health utility in the Multicenter Uveitis Steroid Treatment Trial. Elizabeth A. Sugar1, 3, A. E. Burke2, 3, L. T. Drye2, 3, J. Holbrook2, 3, J. H. Kempen5, 6, J. E. Thorne2, 4, K. D. Frick7. 1Biostatistics, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; 2Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; 3Center for Clinical Trials, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; 4Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD; 5 Ocular Inflammation Service, The University of Pennsylvania, Philadelphia, PA; 6Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, The University of Pennsylvania, Philadelphia, PA; 7Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD *CR, f 608 Thursday, May 09, 2013 10:30 AM-12:15 PM Anatomy/Pathology 526 Anatomy Challenges for the Future 5939 — 11:30 Sox9 regulates the formation and branching morphogenesis of mouse ocular glands. Ziyan Chen2, 1, J. Huang1, Y. Liu1, D. C. Beebe1, 3. 1Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO; 2Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China; 3Cell Biology and Physiology, Washington University in St. Louis, St. Louis, MO *CR 5940 — 11:45 Identification of Signaling Pathways involved in Retina-Lens Tissue Interactions using Embryos Over-Expressing Pairedless Pax6 (Pax6ΔPD) Gene. Vijay K. Kalaskar1, J. D. Lauderdale2. 1Neuroscience Division of Biomedical & Health Sciences Institute, University of Georgia, Athens, GA; 2Cellular Biology, University of Georgia, Athens, GA 5941 — 12:00 Topical small molecule translational bypass therapy rescues Pax6 aniridia mutant phenotype. Cheryl Y. GregoryEvans, X. Wang, A. Metcalfe, X. Shan, K. GregoryEvans. Ophthalmology, University of British Columbia, Vancouver, BC, Canada 609 Moderators: Ludwig M. Heindl and Robert J. Zawadzki Thursday, May 09, 2013 10:30 AM-12:15 PM 5935 — 10:30 Anatomy of CD31+ blood vessels and LYVE1+ macrophages in the adult human sclera. Simona L. Schlereth1, F. Schroedl2, R. Grajewski1, C. Cursiefen1, L. M. Heindl1. 1 Ophthalmology, University of Cologne, Cologne, Germany; 2Paracelsus Medical University, Salzburg, Austria *CR 527 Cataract II 5936 — 10:45 Optic Nerve Parameters in Preterm and Full Term Infants Using Spectral Domain Optical Coherence Tomography (SDOCT). Amy Y. Tong1, R. S. Maldonado2, D. Tran-Viet2, A. L. Rothman1, E. L. Yuan2, A. M. Dubis2, S. Stinnett2, M. A. El-Dairi2, S. F. Freedman2, C. A. Toth2. 1Duke University School of Medicine, Durham, NC; 2Duke Eye Center, Durham, NC *CR 5938 — 11:15 Canonical Wnt signaling is required for lacrimal gland formation, eyelid closure and to suppress corneal cell fate in mouse conjunctival and eyelid epithelium. Jie Huang1, Y. Liu1, D. C. Beebe1, 2. 1Ophthalmology, Washington University, Brentwood, MO; 2Cell Biology and Physiology, Washington University, St. Louis, MO *CR Moderators: Linda Musil and Michael Wormstone 5942 — 10:30 Effects of basic FGF on the regeneration of lens in New Zealand Albino rabbits. Zhenzhen Liu, M. Wu, Y. Zhu, W. Zhang, X. Tan, S. Huang, F. Shang, Y. Liu. Lab of Cataract Prevention and Treatment, Zhongshan Ophthalmic Center, Guangzhou, China 5943 — 10:45 FGF2 Antagonizes the TGFβ2Induced Aberrant Expression of Tropomyosin and α-Smooth Muscle Actin in Mouse and Human Lens Epithelial Cells and Has a Role in Posterior Capsule Opacity. Eri Kubo1, N. Hasanova1, H. Osada1, E. Kiyokawa2, H. Sasaki1, N. Fatma3, D. P. Singh3. 1Department of Ophthalmology, Kanazawa Medical University, Ishikawa, Japan; 2Department of Oncogenic Pathology, Kanazawa Medical University, Ishikawa, Japan; 3Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE 5944 — 11:00 Increased Matrix Rigidity Drives Repair Cell Transdifferentiation into Myofibroblasts in a PCO Model. Janice L. Walker1, 2, B. Bleaken1, M. Stepp3, 4, A. S. Menko1, 2. 1 Pathology, Anatomy & Cell Biology, Thomas Jefferson University, Philadelphia, PA; 2Wills Vision Research Center at Jefferson, Philadelphia, PA; 3 Department of Anatomy and Regenerative Biology, The George Washington Universtiy, Washington, DC; 4Department of Ophthalmology, The George Washington Universtiy, Washington, DC f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 373 Thursday Papers/ Minisymposium 10:30 am – 12:15 pm 5937 — 11:00 Expression of the Lymphangiogenic Marker Podoplanin (D2-40) in Human Fetal Eyes. Martina C. Herwig1, K. Münstermann2, U. Klarmann3, K. U. Loeffler1, A. M. Müller2. 1Dept. of Ophthalmology, University of Bonn, Bonn, Germany; 2Dept. of Pediatric Pathology, University of Bonn, Bonn, Germany; 3 Institute of Medical Biometry, University of Bonn, Bonn, Germany Lens 5945 – 5963 – Thursday – Papers/Minisymposium 5945 — 11:15 STEP Phosphatase and AMPA Receptor GluA2 Regulation in DiabetesInduced Cataract in Rabbit. Peter Frederikse1, C. Kasinathan1, M. Bhattacharyya1, N. J. Kleiman2. 1 University of Medicine and Dentistry of New Jersey, Newark, NJ; 2Mailman School of Public Health, Columbia University, New York City, NY *CR 5946 — 11:30 APC-Coated Intraocular Lenses Reduce the Occurrence of PCO in a Human Anterior Chamber Model. Raffael Liegl, C. M. Wertheimer, M. Kernt, A. Wolf, A. Kampik, K. EiblLindner. Ophthalmology, Ludwig-MaximiliansUniversity Munich, Muenchen, Germany *CR 5947 — 11:45 The study of surface properties of intraocular lens by nanometric analysis. Jun Kong1, 2, N. Yang1, X. Li1, Y. Lu1, J. Zhang1. 1 Ophthalmology, the 4th Affiliated Hospital of China Medical University, Shenyang, China; 2 Ophthalmology, UCSD, San Diego, CA 5948 — 12:00 Epilepsy Cataract: Valproic Acid Suppresses the Nrf2 Dependent Stress/ Antioxidant Protection. Toshimichi Shinohara1, P. Periyasamy1, K. R. Bidasee2, M. Ayaki3, E. Rajan1. 1Ophthalmol and Vis Sci, Univ of Nebraska Medical Center, Omaha, NE; 2Pharmacology and Experimental Neuroscience, Univ of Nebraska Medical Center, Omaha, NE; 3Ophthalmology, Mita Hospital, Tokyo, Japan 611-614 Thursday, May 09, 2013 10:30 AM-12:15 PM Retinal Cell Biology 528 Photoreceptor Degeneration and Death Moderators: Rong Wen and Xi-Qin Ding Thursday Papers/ Minisymposium 10:30 am – 12:15 pm 5949 — 10:30 Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the Unfolded Protein Response. Marina S. Gorbatyuk1, S. Choudhury2, S. R. Nashine2, Y. Bhootada1, A. S. Lewin3, O. Gorbatyuk3. 1Vision Sciences, UAB, Birmingham, AL; 2Cell Biology and Anatomy, UNTHSC, Fort Worth, TX; 3Molecular Genetics & Microbiology, UF, Gainesville, FL *CR 5950 — 10:45 How long does a photoreceptor take to die? Temporal characteristics of neuronal cell death in the retina. Francois Paquet-Durand1, A. Sahaboglu-Tekgöz1, O. Paquet-Durand2, J. Dietter1, P. A. Ekstrom3, B. Hitzmann2, M. Ueffing1. 1Experimental Ophthalmology, Institute for Ophthalmic Research, Tuebingen, Germany; 2 Institute of Food Science and Biotechnology, University of Stuttgart Hohenheim, Stuttgart, Germany; 3Clinical Sciences, University of Lund, Lund, Sweden 5951 — 11:00 Expression and localization of cell cycle and proliferation genes in early retinal degeneration models. Sem Genini, K. L. Gardiner, G. D. Aguirre. Clinical Studies, Univ of Pennsylvania, Sch Veterinary Med, Philadelphia, PA 5957 — 10:45 Risk factors for lacking adequate refractive correction in the U.S., NHANES 1999-2008. Susan Vitale, R. Sperduto, E. Y. Chew, F. L. Ferris. Div Epidemiol & Clin Applications, National Eye Inst/NIH, Bethesda, MD *CR 5952 — 11:15 cGMP Accumulation Causes Cone Degeneration in CNG Channel Deficiency. Arjun Thapa1, J. Xu1, L. M. Morris1, H. Ma1, S. Michalakis2, M. Biel2, W. Baehr3, A. M. Dizhoor4, I. V. Peshenko4, X. Ding1. 1Cell Biology, Univeristy of OKlahoma, Oklahoma City, OK; 2Center for Integrated Protein Science Munich (CIPSM) and Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, München, Germany; 3The John A. Moran Eye Center, University of Utah, Salt Lake CIty, UT; 4 Department of Basic Sciences and Pennsylvania College of Optometry, Salus University, Elkins Park, PA 5958 — 11:00 Heterogeneity of effects in refractive error: lessons from the CREAM Consortium genome-wide association metaanalysis. Christopher J. Hammond1, P. G. Hysi1, V. J. Verhoeven2, C. C. Klaver2. 1Ophthalmology, King’s College London, London, United Kingdom; 2 Ophthalmology & Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands *CR 5953 — 11:30 Exploration of the Mechanisms of Cone Photoreceptor Death in the Deficiency of Phosphodiesterase. Lynsie M. Morris1, Z. D. Ma1, A. Thapa1, H. Ma1, S. Michalakis2, M. Biel2, W. Baehr3, X. Ding1. 1Cell Biology, OU Health Sciences Center, Oklahoma City, OK; 2Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany; 3John A. Moran Eye Center, University of Utah, Salt Lake City, UT 5954 — 11:45 Genetic ablation of DHDDS induces photoreceptor degeneration. Rong Wen, Y. Li, Z. Wang, B. L. Lam, Y. Li. Bascom Palmer Eye Inst, University of Miami, Miami, FL *CR 5955 — 12:00 Rip3 knockdown rescues photoreceptor cell death in pde6c zebrafish model of achromatopsia. Ishaq Ahmed Viringipurampeer, Z. Mohammadi, X. Shan, K. Gregory-Evans, C. Y. Gregory-Evans. Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada 615-617 Thursday, May 09, 2013 10:30 AM-12:15 PM 5959 — 11:15 The role of time outdoors on the progression of refractive error in Australian children. Kathryn A. Rose1, A. French1, P. Mitchell2, I. G. Morgan3. 1Discipline of Orthoptics, University of Sydney, Sydney, NSW, Australia; 2Department of Ophthalmology, University of Sydney, Sydney, NSW, Australia; 3Research School of Biology, Australian National University, Canberra, ACT, Australia *CR 5960 — 11:30 Influence of education on penetrance of myopia genes. Caroline C. Klaver1, 2, V. J. Verhoeven1, 2, G. H. Buitendijk1, 2, J. R. Vingerling1, 2. 1Ophthalmology, Erasmus Medical Center, Rotterdam, Netherlands; 2Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands *CR 5961 — 11:45 School readiness, behavioural and emotional difficulties: the impact of strabismus and its treatment. Phillippa Cumberland1, 3, J. S. Rahi1, 2. 1MRC Centre for Epidemiology of Child Health, UCL Institute of Child Health, London, United Kingdom; 2UCL Institute of Ophthalmology, London, United Kingdom; 3Ulverscroft Vision Research Group, London, United Kingdom 5962 — 12:00 The Magnitude and Symmetry of Refractive and Corneal Astigmatism in Children. John D. Twelker, J. M. Miller, D. H. Messer, E. M. Harvey. Ophthal & Vision Science, University of Arizona, Tucson, AZ Clinical/Epidemiologic Research 529 Refractive Error and Visual Function: What Affects How We See 618-620 Thursday, May 09, 2013 10:30 AM-12:15 PM Physiology/Pharmacology Moderators: Susan Vitale and Kathryn A. Rose 5956 — 10:30 Atherosclerosis, Inflammation and Decline in Contrast Sensitivity: The Beaver Dam Offspring Study. Karen J. Cruickshanks1, 2, D. M. Nondahl1, D. S. Dalton1, G. Huang3, 2, B. E. Klein1, R. Klein1, F. Nieto2, C. R. Schubert1. 1 Ophthalmology and Visual Sciences, U of WI SMPH, Madison, WI; 2Population Health Sciences, U of WI SMPH, Madison, WI; 3National Chiao Tung University, Hsinchu, Taiwan 530 Gene Therapy and Delivery Moderators: Tao L. Lowe and Caterina Gagliano 5963 — 10:30 Oral delivery of bioencapsulated myelin basic protein ameliorate amyloid burden and RGC loss in transgenic mouse model of Alzheimer’s disease. Qiuhong Li1, A. Verma1, P. Zhu1, P. K. Shil1, N. Kohli2, D. Westerveld2, H. Daniell2. 1Ophthalmology, University of Florida, Gainesville, FL; 2University of Central Florida, Orlando, FL The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 374 Thursday – Papers/Minisymposium – 5964 – 5981 5964 — 10:45 Treatment of Patients with Leber Congenital Amaurosis Type 2 with an AAV Vector Expressing RPE65. Tim Stout1, R. G. Weleber1, M. McBride1, D. J. Wilson1, D. Peters1, M. R. Humphries3, T. R. Flotte3, L. J. Jensen1, A. Lauer1, J. D. Chulay2. 1Ophthalmology, Casey Eye Institute-OHSU, Portland, OR; 2AGTC Inc, Alachua, FL; 3School of Medicine, University of Massachusetts, Worcester, MA *CR, f 5965 — 11:00 Sustained Therapeutic Reversal of Canine Bestrophinopathy with Gene Therapy using Recombinant AAV2. Karina E. Guziewicz1, A. M. Komaromy2, S. Iwabe1, A. V. Cideciyan3, E. V. Dutrow1, B. Zangerl4, W. A. Beltran1, S. G. Jacobson3, W. W. Hauswirth5, G. D. Aguirre1. 1 Clinical Studies, University of Pennsylvania, Philadelphia, PA; 2Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, MI; 3Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA; 4Centre for Eye Health, University of New South Wales, Kensington, NSW, Australia; 5Department of Ophthalmology, University of Florida, Gainesville, FL *CR 5966 — 11:15 Vertical Gene Transfer of Mutant Human G11778A ND4 in Next Generation MitoMice. Hong Yu, S. S. Ozdemir, T. Chou, V. Porciatti, J. Guy. Ophthalmology, Bascom Palmer Eye Inst, Univ of Miami, Miami, FL 5967 — 11:30 Gene Therapy with the Mitochondrial Heat Shock Protein 70 (mtHSP70) Chaperone Supresses Neurodegeneration and Irreversible Visual Loss in Experimental Optic Neurits. Venu Talla, S. S. Ozdemir, T. Chou, V. Porciatti, J. Guy. Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL 5969 — 12:00 Gene therapy in Leber congenital amaurosis due to rpe mutations: results of the first six patients included in a clinical trial. Guylene Le Meur1, P. Lebranchu2, Y. Péréon3, S. Schmitt4, S. Bézieau5, P. Moullier6, F. Rolling7, M. Weber8. 1CHU hotel dieu, Nantes, France; 2CHU hotel Dieu, Nantes, France; 3CHU hotel Dieu, Nantes, France; 4CHU hotel Dieu, Nantes, France; 5CHU hotel Dieu, Nantes, France; 6 INSERM UMR 1089, Nantes, France; 7INSERM UMR 1089, Nantes, France; 8CHU hotel Dieu, Nantes, France f Thursday, May 09, 2013 10:30 AM-12:15 PM Low Vision Group 531 Beyond Large Print: Advances in Accessibility and Technology for the Visually Impaired - Minisymposium Over the last 20 years technological innovation has advanced at an amazing pace and in doing so has revolutionized accessibility to information for people with vision impairments. Presenters in this symposium will provide an overview of how recent and future advances in technology and computer vision can be utilized by vision scientists to provide immediate and potentially life-changing solutions for individuals with vision impairments. Moderators: James B. Nolan, Ava K. Bittner and Alexandra R. Bowers — 10:30 Introduction — 10:40 Oberdorfer Award in Low Vision Presentation 5970 — 10:45 Oberdorfer Award in Low Vision – Using the Cloud and Emerging Technologies to Provide On-demand Low Vision Solutions Anytime, Anywhere, on Any Device. Gregg Vanderheiden. Industrial Engineering and Biomedical Engineering, University of WisconsinMadison, Madison, WI 5971 — 11:15 Accessibility and Vision Rehabilitation Science: Tear Down That Wall!. Aries Arditi. Visibility Metrics LLC, Chappaqua, NY 5972 — 11:35 Computer Vision-based Assistive Technology for the Visually Impaired. James Coughlan. Smith-Kettlewell Eye Research Institute, San Francisco, CA 5973 — 11:55 Using Text Detection to Help Low Vision Users. Peter Hallinan. The Blindsight Corporation, Berkeley, CA *CR TCC 303 Thursday, May 09, 2013 10:30 AM-12:15 PM Cornea 5975 — 10:45 Type III Intermediate Filament Overexpression in the Genesis of Corneal Fibrosis. Royce Mohan1, L. Cauley2, P. BargagnaMohan1. 1Neuroscience, University of Connecticut Health Center Health Center, Farmington, CT; 2 Immunology, University of Connecticut Health Center, Farmington, CT *CR 5976 — 11:00 Genome-wide transcriptional analysis of differentially expressed genes in diabetic, healing corneal epithelial cells. Fushin X. Yu. Dept of Ophthalmology, Wayne State Univ/ Kresge Eye Inst, Detroit, MI 5977 — 11:15 Corneal epithelial-neuronal signaling is compromised under environmental stress. Vickery E. Trinkaus-Randall, A. Lee, K. Derricks, M. Nugent. Ophthalmology L904, Boston University Sch of Med, Boston, MA 5978 — 11:30 Ciliary neurotrophic Factor accelerates corneal Nerve Regeneration in a Murine Model. Rudolf F. Guthoff, M. Reichard, M. Hovakimyan, O. Stachs. Ophthalmology, University of Rostock, Rostock, Germany 5979 — 11:45 The Mechanotransducers YAP and TAZ are Modulated by Substratum Compliance in Corneal Stromal Cells and during Corneal Wound Healing. Christopher J. Murphy1, 2, S. M. Thomasy1, V. K. Raghuanthan1, C. M. Reilly3, P. Russell1. 1Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA; 2Ophthalmology & Vision Science, School of Medicine, University of California, Davis, Davis, CA; 3Pathology, Immunology & Microbiology, School of Veterinary Medicine, University of California, Davis, Davis, CA *CR 5980 — 12:00 Anti-inflammatory therapy changes fate of alkali burned corneas associated with dry eye. Cintia S. De Paiva, F. S. Pelegrino, E. A. Volpe, S. C. Pflugfelder. Ophthalmology, Baylor College of Medicine, Houston, TX *CR TCC 305 Thursday, May 09, 2013 10:30 AM-12:15 PM Eye Movements / Strabismus / Amblyopia / Neuro-Ophthalmology 533 Disruptions to Visual Development: Detection, Treatment and Consequences 532 Corneal Wound Repair and Healing Moderators: Susan A. Cotter and Agnes M. Wong Moderators: Winston W. Kao and Peter S. Reinach 5974 — 10:30 Effect of Advanced Glycation End Products on apoptosis of Human Corneal Epithelial Cells. Xinyi Wu. Ophthal QiLu Hosp/ Ophthal, Shandong University, Jinan, Shandong, China 5981 — 10:30 Beyond Screening for Risk Factors…The Objective Detection of Strabismus and Amblyopia. Susan E. Yanni1, R. M. Jost1, C. L. Beauchamp2, D. R. Stager2, S. David3, L. Dao3, M. R. Nolan1, E. E. Birch1, 4. 1Retina Foundation of the Southwest, Dallas, TX; 2Pediatric Ophthalmology and the Center for Adult Strabismus, Dallas, TX; 3 Pediatric Ophthalmology and Adult Strabismus, Plano, TX; 4Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 375 Thursday Papers/ Minisymposium 10:30 am – 12:15 pm 5968 — 11:45 AAV-mediated gene therapy restores retinal function and vision in the RPGRIP1-deficient dog. Lolita Petit1, E. Lhériteau1, M. Weber2, G. Le Meur2, J. Deschamps3, P. Moullier1, 4, F. Rolling1. 1Inst de Recherche Therapeutique 1, Lab de Therapie Genique INSERM UMR 1089, Nantes, France; 2Service d’Opthalmologie, CHU-Hôtel Dieu, Nantes, France; 3Emergency and Critical Care Unit, ONIRIS, Nantes-Atlantic College of Veterinary Medicine-Food Science and Engineering, Nantes, France; 4Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL TCC LL 4/5 5982 – 5987 – Thursday – Papers/Minisymposium 5982 — 10:45 Are Referrals From the Plusoptix S09 Significantly More Accurate Than the LEA/Random Dot E Screening System for Preschool Children Ages 3-5. Joannah Vaughan, R. Arao, T. Dale, M. F. Chiang, D. J. Karr. Casey Eye Institute, Oregon Health & Science University, Portland, OR *CR 5983 — 11:00 The relationship between visual function and scores on the Beery VisualMotor Integration test in 4.5 year old children born with developmental risk factors. Arijit Chakraborty1, N. S. Anstice1, R. J. Jacobs1, J. E. Harding2, J. Paynter2, T. Wouldes3, B. Thompson1. 1 Optometry and Vision Science, University of Auckland, Auckland, New Zealand; 2Liggins Institute, University of Auckland, Auckland, New Zealand; 3Psychological Medicine, University of Auckland, Auckland, New Zealand *CR 5984 — 11:15 Comparison of electroretinographical responses in albinism, idiopathic infantile nystagmus and healthy controls. Zhanhan Tu1, C. Degg2, I. Gottlob1, F. A. Proudlock1. 1Opthalmology Group, University of Leicester, Leicester, United Kingdom; 2Medical Physics, University Hospitals of Leicester, Leicester, United Kingdom 5985 — 11:30 Timing matters: Relationship between age at initial surgery and monocular grating acuity at 12 months in the Infant Aphakia Treatment Study (IATS). E Eugenie Hartmann1, M. J. Lynn2, S. R. Lambert3. 1 Department of Vision Sciences, Univ of Alabama at Birmingham, Birmingham, AL; 2Department of Biostatistics and Bioinformatics; Rollins School of Public Health, Emory University, Atlanta, GA; 3Department of Ophthalmology; School of Medicine, Emory University, Atlanta, GA f Thursday Papers/ Minisymposium 10:30 am – 12:15 pm 5986 — 11:45 A prospective non-randomized study on early vs standard surgery for infantile esotropia in children: An interim report on optokinetic response. Agnes M. Wong1, 2, H. C. Goltz1, 2, A. Blakeman2, L. Colpa1. 1Ophthalmology & Vision Sciences, Hospital for Sick Children, Toronto, ON, Canada; 2Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada f 5987 — 12:00 Factors Associated with Poor Health-Related Quality of Life in Adult Strabismus. Sarah R. Hatt, D. A. Leske, L. Liebermann, J. M. Holmes. Ophthalmology, Mayo Clinic, Rochester, MN The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 376 Thursday – Posters – 5988 – 6008 Exhibit Hall A0032-A0042 Thursday, May 09, 2013 10:30 AM-12:15 PM Immunology/Microbiology / Cornea 534 Corneal Infection/Inflammation II Moderator: Alison M. McDermott 5988 — A0032 Determining the Efficacy of a Novel Targeted Therapeutic Approach Against Herpes Simplex Virus-1 in an Organotypically Cultured Corneal Model. Paul J. Park1, T. ValyiNagy3, D. Shukla1, 2. 1Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL; 2Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL; 3Pathology, University of Illinois at Chicago, Chicago, IL 5989 — A0033 STAT3/SOCS3 axis modulates CD8-mediated host immunity against HSV-1. Fatemeh Navid1, C. Yu1, I. M. Dambuza1, G. Frank2, C. Egwuagu1. 1Laboratory of Immunology, NEI, Bethesda, MD; 2Cellular Biology Section, NIAID, Bethesda, MD 5990 — A0034 Targeting host kinases as potential therapeutic targets for the treatment of herpes keratitis. Oleg Alekseev, J. AzizkhanClifford. Biochemistry & Molecular Biology, Drexel Univ College of Medicine, Philadelphia, PA 5991 — A0035 Efficacy of HSV1-specific meganucleases in a mouse model of relapsing herpes keratitis. Marc Labetoulle1, 2, E. E. Gabison3, A. Rousseau1, N. Huot2, D. Pasdeloup2, S. Barradeau4, C. Mahiet4, B. Chapelier3, M. Breckler2. 1Ophthalmology, Hopital Bicetre, South Paris University, Le Kremlin Bicetre, France; 2Laboratoire de Virologie Moleculaire et Structurale, CNRS UPR 3296, Gif sur Yvette, France; 3Institut de la Vision, Paris, France; 4 Genomic Vision, Bagneux, France *CR 5994 — A0038 Cytokine Profiling in Mouse Cornea During Wound Healing in Response to CAP37 Treatment. Anne Kasus-Jacobi1, G. L. Griffith2, M. R. Lerner3, H. A. Pereira1, 2. 1 Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK; 2 Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK; 3Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 5995 — A0039 Expression of PAR1 and 2 on Human Corneal Epithelial Cells and Induction of Pro-inflammatory Cytokine Secretion by Acanthamoeba MIP-133 and aPA. Hassan Alizadeh1, 2, M. Abdi1, 2. 1Cell Biology and Anatomy, UNTHSC Fort Worth TX, Fort Worth, TX; 2North Texas Eye Research Institute, UNTHSC, Fort Worth, TX 5996 — A0040 Role of ST2 Signaling in IL33 Induced Inflammation in Human Corneal Epithelium. Jing Lin, G. Zhao, L. Zhang. Ophthalmology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, China 5997 — A0041 Antimicrobial Peptides in the In Vitro Corneal Response to Fungal Pathogens. Satya Sree N. Kolar, H. Baidouri, A. McDermott. Optometry and Vision Sciences, University of Houston, College of Optometry, Houston, TX 5998 — A0042 Corneal epithelial-cell necrosis and apoptosis directly induced by fungal isolates from patients with keratomycosis. Pablo L. Goldschmidt1, R. Zemihi1, D. Ghoubay-Benallaoua1, C. Temstet1, L. Batellier1, V. Borderie2, L. Laroche2, C. Chaumeil1. 1Laboratoire, Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, Paris, France; 2Service 5, Centre Hospitalier National d’Ophtalmologie des Qui, Paris, France Exhibit Hall A0062-A0116 Thursday, May 09, 2013 10:30 AM-12:15 PM Cornea / Visual Psychophysics / Physiological Optics 5993 — A0037 Expression of NOD-like receptors(NLRs) and NODs in corneal diseases. Na-Kyung Ryoo1, 2, J. Ko2, H. Lee2, M. Kim1, W. Wee1, J. Oh1, 2. 1Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea; 2 Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea 5999 — A0062 Toll-like Receptor Agonists Stimulate Matrix Metalloproteinase-9 Production in Ocular Surface Cells. Rachel L. Redfern, K. Stout, K. Dionne. College of Optometry, University of Houston, Houston, TX 535 Dry Eye and Lacrimal Gland V Moderators: De-Quan Li and Norihiko Yokoi 6000 — A0063 Corneal Epithelial Cell Protective and Wettability-enhancing Properties of Hyaluronic Acid + PEG 8000 in an Artificial Tear Product. Stephen Davio, M. E. Cavet, K. L. Harrington, A. Walsh, Z. Marlowe, B. Glass, P. Sarkar. Pharmaceutical R&D, Bausch & Lomb, Rochester, NY *CR 6002 — A0065 Comparison of two rodent models of dry eye induced by Scopolamine. Pierre-Paul Elena1, N. Cimbolini1, S. Antonelli1, L. Feraille1, S. Barabino2, P. Margaron1. 1Iris Pharma, La Gaude, France; 2Clinica Oculistica, Genova, Italy *CR 6003 — A0066 The Composition of Fatty Acids in Human Meibum. Tomo Suzuki1, 2, S. Kamada1, 2, T. Tajika3, S. Fujiwara4, S. Kinoshita1. 1 Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Ophthalmology, Kyoto City Hospital, Kyoto, Japan; 3Senju Pharmaceutical Co. LTD., Osaka, Japan; 4Shimadzu TechnoResearch, INC., Kyoto, Japan *CR 6004 — A0067 Topical atorvastatin for the treatment of dry eye associated with blepharitis. Stephanie L. Watson1, K. G. Ooi1, 2, F. A. Billson1, D. Wakefield3. 1Ophthalmology, Save Sight Institute, University of Sydney, Sydney, NSW, Australia; 2 Department of Ophthalmology, Prince of Wales Hospital, Sydney, NSW, Australia; 3Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia *CR, f 6005 — A0068 Optical quality after instillation of three different eye drops for dry eye. Shizuka Koh1, N. Maeda1, C. Ikeda1, 2, Y. Takai1, 2, H. Fujimoto1, Y. Oie1, T. Soma1, M. Tsujikawa1, K. Nishida1. 1Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan; 2 Research & Development, Rohto Pharmaceutical CO.,LTD, Kyoto, Japan *CR 6006 — A0069 Effects of diquafosol sodium eye drops on tear film stability. Seika Den1, H. Iseda1, M. Dogru1, 2, J. Shimazaki1, 2. 1 Ophthalmology, Tokyo Dental College, Chiba, Japan; 2Ophthalmology, Keio University School of Medicine, Tokyo, Japan *CR, f 6007 — A0070 A multi-lamellar sandwich model of the tear film lipid layer, TFLL. Peter E. King-Smith1, M. D. Bailey1, R. J. Braun2. 1 Optometry, Ohio State University, Columbus, OH; 2 Mathematical Sciences, University of Delaware, Newark, DE 6008 — A0071 Observation of Spreading and Mechanical Properties of the Tear Film Lipid Layer Using A High Performance Video-Based Interferometry System. Daniel R. Powell, P. E. King-Smith, H. L. Chandler. Vision Science, Ohio State University, Columbus, OH f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 377 Thursday Posters 10:30 am – 12:15 pm 5992 — A0036 Preclinical evaluation of new therapies in a fungal keratitis rat model. M Livia Bajenaru, A. C. Santos, M. J. Falter, M. Ruggeri, J. Ponmattam, E. P. Hernandez, M. Abou Shousha, V. L. Perez, D. Miller, E. C. Alfonso. Ophthalmology, Univ of Miami, Bascom Palmer Eye Inst, Miami, FL *CR 6001 — A0064 Change of Tear Secretion in the Lacrimal Glands of High-Fat Diet-Fed C57BL/6J Mice. Takaaki Inaba, M. Kawashima, A. Ito, M. Watanabe, K. Shinmura, T. Kawakita, K. Tsubota. Keio University, Tokyo, Japan *CR 6009 – 6034 – Thursday – Posters 6009 — A0072 Symptoms and Findings in a Norwegian Cohort of Patients with Meibomian Gland Dysfunction. Ola M. Rygh1, 2, J. Eidet1, 5, X. Chen1, 5, T. P. Utheim1, 3, A. Thyholdt4, O. Utheim1, 3, F. Stojanovic1, 5, A. Stojanovic1, 5, S. Raeder1, 6. 1Torreoyneklinikken AS, Oslo, Norway; 2 Eye department, Hospital of Vestfold, Tonsberg, Norway; 3Department of Medical Biochemistry, Oslo University Hospital Ulleval, University of Oslo, Oslo, Norway; 4dbConsult, Tromso, Norway; 5 Synslaser Kirurgi, Oslo, Norway; 6Department of Clinical Medicine, University of Bergen, Bergen, Norway 6010 — A0073 Effects of alkali burn of the ocular surface on meibomian gland structure in mice. Shin Mizoguchi1, Y. Okada1, R. Arita2, S. Saika1. 1Ophthalmology, Wakayama Medical University, Wakayama, Japan; 2Itoh Clinic, Tokyo, Japan *CR 6011 — A0074 Effect of Collection Method on the Lipid Composition of Meibum Samples. Carolina Kunnen1, 2, S. H. Brown4, B. A. Holden1, 3 , P. Lazon De La Jara1, 2, E. B. Papas1, 3. 1Brien Holden Vision Institute, Sydney, NSW, Australia; 2 School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, Australia; 3Vision CRC, Sydney, NSW, Australia; 4 School of Health Sciences, University of Wollongong, Wollongong, NSW, Australia *CR 6012 — A0075 Infra-Red Imaging of Meibomian Glands & Evaluation of the Lipid Layer in Sjogren’s Syndrome Patients. Sruthi Srinivasan, K. L. Menzies, L. W. Jones. School of Optometry, University of Waterloo, Waterloo, ON, Canada *CR 6013 — A0076 Analysis of a potential Meibomian Gland Dysfunction-Specific Symptom Questionnaire in an Independent Sample. Justin T. Kwan1, M. M. Hom2, J. R. Paugh1. 1 Contact Lens, Dry Eye, Research, Southern California College of Optometry, Fullerton, CA; 2 Private Practice, Azusa, CA *CR Thursday Posters 10:30 am – 12:15 pm 6014 — A0077 Cigarrete Smoking And Diabetes But Not Increased Levels Of Cholesterol, Increase Lipid Peroxidation In Human Tears. Soledad Benlloch-Navarro1, V. Sanchez-vallejo1, I. Almansa1, E. Arnal2, D. Silvestre1, M. Miranda1. 1Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Moncada, Spain; 2Fundación Oftalmológica del Mediterráneo, Valencia, Spain 6015 — A0078 Role of lipid emulsion eye drops in the improvement of lipid layer thickness measured with Lipiview. Lara Borrego1, 2, F. Saenz-Frances1, D. Finis2, J. M. Benitezdel-Castillo1, G. Geerling2. 1Ocular Surface, Hospital Clinico San Carlos, Madrid, Spain; 2 Ophthalmology, 2University Clinic Hospital, Düsseldorf, Germany *CR 6016 — A0079 Benzalkonium chloride-induced rat dry eye model mimics hyperosmolarity in tear volume deficient dry eye disease. Davi L. Marques1, M. Alves1, 2, C. Modulo1, L. Malki1, P. Reinach1, E. M. Rocha1. 1Universidade de São Paulo, Ribeirão Preto, Brazil; 2Pontific Catholic University of Campinas, Campinas, Brazil 6017 — A0080 Debridement of the Lower Lid Margin and Line of Marx is effective in increasing meibomian gland function and patient comfort. Caroline A. Blackie1, 2, D. R. Korb1, 2. 1 TearScience, Morrisville, NC; 2Korb Associates, Boston, MA *CR 6018 — A0081 The effect of increased periocular humidity on lipid layer thickness and ocular comfort of symptomatic contact lens wearers. Samuel Kim1, C. A. Blackie1, 2, D. R. Korb1, 2. 1TearScience, Morrisville, NC; 2Korb Associates, Boston, MA *CR 6019 — A0082 The Avian Membrana Nictitans: Anatomy and Function. Charles S. Schobert, L. B. Teixeira, R. R. Dubielzig. Dept of Pathobiological Sciences, UW-Madison School of Vet Med, Madison, WI *CR 6020 — A0083 Prevalence of incomplete blinking in dry eye patients evaluated with tear film interferometry. Joanne Shen. Mayo Clinic in Arizona, Scottsdale, AZ 6021 — A0084 Expression of proinflammatory cytokines in tears of aqueous-deficient dry eyes. Yan Wang, J. Xiang, J. Xu. Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China 6022 — A0085 Unraveling diagnostic correlates indicative of Sjögren’s Syndrome. Eduardo M. Rocha, D. Ribeiro, M. Alves, J. S. Paula, P. Reinach. Ophthalmology, FMRP-USP, Ribeirao Preto, Brazil 6023 — A0086 Validation of the Current Symptoms Questionnaire (CSQ): a metaanalytical approach. Ping Situ1, T. L. Simpson2, R. L. Chalmers1, Z. Wu1, C. G. Begley1. 1School of Optometry, Indiana University Bloomington, Bloomington, IN; 2School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada *CR 6024 — A0087 The Influence of Punctal Occlusion on Osmolarity in Dry Eye Subjects. Jessica Schonfeld, J. S. Pepose, M. A. Qazi. Pepose Vision Institute, Chesterfield, MO *CR, f 6025 — A0088 Association between depression and dry eye disease in an adult population. Antoine Labbe1, 2, Y. Wang1, C. Baudouin2, J. B. Jonas1, 3, L. Xu1. 1Ophthalmology, Beijing Institute of Ophthalmology, Beijing TongRen Eye Hospital, Beijing, China; 2Ophthalmology, CHNO National Eye Center, Paris, France; 3Ophthalmology, Medical Faculty Mannheim-Heidelberg, Mannheim, Germany *CR 6026 — A0089 In vitro evaporation rate and stability of four marketed artificial tears. Constanca Coelho, F. Azancoth. Genetics Laboratory, Lisbon Medical School, Lisbon, Portugal *CR 6027 — A0090 Anterior segment OCT study of the pre-corneal film and its relationship with dry-eye patient`s symptoms and quantitative tests of the tear film. Maurizio Fossarello, P. E. Napoli, G. M. Satta, F. Coronella. Ophthalmology, University of Cagliari, Cagliari, Italy 6028 — A0091 Evaluation of the Standard Patient Evaluation of Eye Dryness (SPEED) Questionnaire. Nancy J. Keir1, W. Ngo1, P. Situ5, D. R. Korb3, 4, C. A. Blackie3, 4, T. L. Simpson2. 1School of Optometry-CCLR, University of Waterloo, Waterloo, ON, Canada; 2School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada; 3TearScience, Morrisville, NC; 4Korb Associates, Boston, MA; 5School of Optometry, Indiana University, Bloomington, IN *CR 6029 — A0092 Inhibition of Matrix Metalloproteinases by Mapracorat, a Novel Selective Glucocorticoid Receptor Agonist (SEGRA), in Human Corneal Epithelial Cells. Thomas R. Vollmer, K. L. Harrington, J. Zhang, M. Richardson, M. E. Cavet. Preclinical Pharmacology, Bausch + Lomb, Rochester, NY *CR 6030 — A0093 Histopathologic changes in punctal stenosis. Gary J. Lelli1, A. D. Port3, Y. Chen2. 1Ophthalmology, Weill Cornell Medical College, New York, NY; 2Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY; 3Weill Cornell Medical College, New York, NY 6031 — A0094 Hyperosmolar dryness stress on 3D HCE model: a new tool for pre-clinical assessment of tear substitutes. Barbara De Servi1, C. Olmiere2, M. Meloni1. 1VitroScreen, Milan, Italy; 2 Laboratoires Thea, Clermont-Ferrand, France *CR 6032 — A0095 Ocular manifestations and treatment outcomes of patients with graftversus-host disease. Sankaranarayana Mahesh, C. J. Rapuano, P. K. Nagra, K. M. Hammersmith. Cornea, Wills Eye Institute, Phiiladelphia, PA 6033 — A0096 Thymosin Beta 4 Eye Drops Significantly Improve Signs and Symptoms of Severe Dry Eye in a Physician-Sponsored Phase 2 Clinical Trial. Gabriel Sosne1, S. P. Dunn2, D. Crockford3, C. Kim1, E. Dixon3. 1Ophthal & Anatomy & Cell Biol, Wayne State Univ Sch of Med, Detroit, MI; 2Michigan Cornea Consultants, Southfield, MI; 3RegeneRx Biopharmaceuticals, Rockville, MD *CR, f 6034 — A0097 Biomarkers in the tear fluid during chemical ocular injury in the rabbit model. The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 378 Thursday – Posters – 6035 – 6057 6035 — A0098 Characterization of cultivated Human Oral Mucosal Epithelial Cells (HOMEs) in an autologous culture medium. Camilla Gram, D. Krohn-Hansen, E. Gulliksen, K. Haug, J. K. Slettedal, M. C. Moe, L. Drolsum, B. Nicolaissen, A. Shahdadfar. Department of Ophthalmology, Oslo University Hospital Oslo, Norway, Center for Eye Research, Oslo, Norway 6044 — A0107 Effects of controlled heat delivery to the eyelid margin & eyelid hygiene on symptomatology and the tear film in MGD. Michel Guillon1, 2, C. A. Maissa1, S. Wong1, A. Lane1, B. Bossard1. 1OTG Research & Consultancy, London, United Kingdom; 2School of Life and Health Sciences, Aston University, Birmingham, United Kingdom *CR 6036 — A0099 Effects of lens care solutions on dynamic interfacial properties of human tear lipids. Tatyana F. Svitova, M. C. Lin. Optometry School, Univ of California, Berkeley, Berkeley, CA *CR 6045 — A0108 A Software-based Approach for the Analysis of Lissamine Staining of the Conjunctiva. Keith J. Lane, J. D. Rodriguez, E. Angjeli, G. W. Ousler. Clinical R & D, Ora, Inc., Andover, MA *CR 6037 — A0100 Efficacy of long-term treatment with diquafosol sodium for dry eye due to laser in situ keratomileusis. Ryohei Nejima, Y. Mori, A. Masuda, Y. Maruyama, K. Minami, K. Miyata. Miyata Eye Hospital, Miyakonojyo, Japan 6046 — A0109 Surgical Model for Evaporative Loss Dry Eye Model in the New Zealand White Rabbit. Anthony J. Johnson1, 3, P. Buttke3, I. E. Kochevar2, H. H. Wang1, S. R. Cora1, S. L. DeMartelaere3. 1Ocular Trauma Research, USAISR, Fort Sam Houston, TX; 2Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA; 3SAUSHEC Ophthalmology, San Antonio Military Medical Center, Fort Sam Houston, TX *CR 6038 — A0101 Effect of dynamic changes in the tear film on the optical quality in normal and dry eyes. Johan Hedström, B. Theagarayan. Section of Optometry and Vision Science, Linnaeus University, Kalmar, Sweden 6039 — A0102 Multidimensional scaling of words used to characterize ocular surface discomfort. Trefford L. Simpson, Y. Feng. School of Optometry & Vision Science, University of Waterloo, Waterloo, ON, Canada 6040 — A0103 Changes of Higher Order Aberration depending on Ocular Surface Indicators analyzed by Continuous Measurement after Phacoemusification. Si-Hwan Choi, H. Lim. chungnam national university hospital, department of ophthalmology, daejeon, south korea, Daejeon, Republic of Korea 6041 — A0104 Hyperosmolar conditions Increase benzalkonium chloride (BAK) toxicity in an in vitro cornea wound healing model and an in vivo dry eye mouse model. Hong Liang1, 2, C. Baudouin1, 2, P. Daull3, J. Garrigue3, F. BrignoleBaudouin1, 2. 1Ophthalmology-Hosp Paris, CHNO Des Quinze-Vights, Paris, France; 2INSERM, UMR_S968, Vision Institute, Paris, France; 3 Novagali Pharma, Evry, France *CR 6043 — A0106 Updated Fluorophotometry Technique Correlates With Signs and Symptoms of Dry Eye Better Than Schirmer’s Test. Colleen Heckley1, E. Angjeli1, K. J. Lane1, C. Ahearn1, D. L. Welch2, G. W. Ousler2. 1R&D, Ora, Inc., Andover, MA; 2Ora, Inc., Andover, MA *CR 6048 — A0111 The Influence of Punctal Occlusion on Osmolarity in Dry Eye Subjects. David C. Eldridge, M. S. Berg, B. D. Sullivan, W. D. Townsend. TearLab Corp, Bixby, OK *CR 6049 — A0112 Transcultural Validation of McMonnies Questionnaire for Mexican Population. Alejandro Babayan1, N. RamosBetancourt2, F. Beltran2, J. D. Martinez2, C. Santacruz Valdes3, C. Ramírez-Assad2, E. M. Mora Juarez2, E. Hernandez-Quintela2. 1Cornea, Fundacion Hospital “Nuestra Senora de la Luz”, Mexico City, Mexico; 2Cornea, Asociación para evitar la ceguera en Mexico, Mexico, Mexico; 3 Cornea, Instituto de Oftalmología Conde de Valenciana, Mexico, Mexico 6050 — A0113 Transcultural Validation of Ocular Surface Disease Index (OSDI) Questionnaire for Mexican Population. Francisco Beltran1, 2, N. Ramos-Betancourt1, 2, J. D. Martinez1, 2, C. Santacruz Valdes3, 2, A. Babayan4, 2, C. Ramírez-Assad2, E. M. Mora Juarez2, E. Hernandez-Quintela1, 2. 1Cornea, Asociación Para Evitar la Ceguera en México, Mexico City, Mexico; 2Colegio de Investigación en Ciencias Visuales, MARVO, Mexico City, Mexico; 3Cornea, Instituto de Oftalmología Conde De Valenciana, Mexico City, Mexico; 4Cornea, Hospital Fundación “Nuestra Señora de la Luz”, Mexico City, Mexico 6052 — A0115 Use of Artificial Tears vs Cold Compresses for the Treatment of Dry Eye. Andrew A. Kao, R. Latkany. Ophthalmology, The New York Eye and Ear Infirmary, New York City, NY *CR, f 6053 — A0116 Long-Term Effects of Cataract Surgery on Tear Film Parameters. Anat Galor1, 2, V. D. Venincasa1, W. J. Feuer2, H. Florez1, 4, D. J. Lee3. 1Miami Veterans Affairs Medical Center, Miami, FL; 2Ophthalmology, Bascom Palmer, Miami, FL; 3Department of Epidemiology and Public Health, University of Miami, Miami, FL; 4 Department of Endocrinology and Geriatrics, University of Miami, Miami, FL *CR Exhibit Hall B0065-B0077 Thursday, May 09, 2013 10:30 AM-12:15 PM Visual Psychophysics / Physiological Optics 536 Inner Retina and Blood Vessels Moderators: Toco Y. Chui and Richard B. Rosen 6054 — B0065 Future Insights on an Ocular Hypertension Model in the White Leghorn Chicken. Jennifer L. Choi1, R. T. Tzekov2, 3, S. S. Choi1. 1New England College of Optometry, Boston, MA; 2The Roskamp Institute, Sarasota, FL; 3 Department of Ophthalmology, University of South Florida, Tampa, FL 6055 — B0066 Detection of flow velocity fluctuations associated with erythrocyte aggregation in diabetic retinopathy by using adaptive optics scanning laser ophthalmoscopy. Akihito Uji, M. Hangai, S. Ooto, S. Arichika, T. Murakami, N. Yoshimura. Ophthalmology, Kyoto Univ Graduate Sch of Med, Kyoto City, Japan *CR 6056 — B0067 Adaptive contrast enhancement in capillary shadow region of AOSLO images using blood cell flow information. Hiroshi Imamura1, T. Yuasa1, H. Sonobe1, A. Uji2, S. Ooto2, M. Hangai2, N. Yoshimura2. 1Canon Inc, Ohta-ku, Japan; 2Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto City, Japan *CR 6057 — B0068 Study of epimacular membranes using adaptative optics high resolution imaging. Hassiba Bouakkaz1, S. Ayello-Scheer1, A. Leseigneur1, C. Devisme1, J. A. Sahel1, 2, M. Paques1, 2. 1Centre Hospitalier National d’Ophtalmologie des Quinze Vingts, Paris, France; 2 Institut de la Vision, Paris, France *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 379 Thursday Posters 10:30 am – 12:15 pm 6042 — A0105 Internal Standard Dilution Indicator Protocol (ISDIP): A Newer Method for the Quantitative Assessment in Tear Lipidomic Studies. Anju Sirohiwal1, J. S. Titiyal1, S. P. Garg1, S. Sen1, 2, S. Baskar Singh1, 3, S. Ghose1, T. Velpandian1, 4. 1Ophthalmology, All India Institute of Medical Sciences, New Delhi, India; 2Ocular Pathology, All India IInstitute of Medical Sciences, New Delhi, India; 3Biophysics, All India IInstitute of Medical Sciences, New Delhi, India; 4Ocular Pharmacology and Pharmacy, All India IInstitute of Medical Sciences, New Delhi, India 6047 — A0110 Clinical Correlations Among Dry Eye Tests, Physical And Metabolic Findings In Diabetes Mellitus Patients. Peter S. Reinach1, 2, J. F. Faustino2, M. Alves2, D. Ribeiro2, J. S. Paula2, E. M. Rocha2. 1Biological Sciences, SUNY College of Optometry, New York, NY; 2Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço., Universidade de São Paulo, Ribeirão Preto, Ribeirao Preto, Brazil 6051 — A0114 Anterior Segment Optical Coherence Tomography changes of ocular surface after topical anti-inflammatory therapy in dry eyes. Pietro E. Napoli, M. Fossarello, F. Coronella, G. M. Satta. Eye Clinic, University of Cagliari, Cagliari, Italy 6058 – 6075 – Thursday – Posters 6058 — B0069 Parietal morphometry of retinal arterioles in health and hypertension using adaptive optics. Edouard Koch1, 2, D. Rosenbaumm3, X. Girerd3, F. Rossant4, M. Paques1. 1 Clinial Investigation Center, Quinze-Vingts Hospital-INSERM, Paris, France; 2Ophthalmology, Versailles Hospital, Versailles, France; 3Cardiology, Pitié Salpétrière Hospital, Paris, France; 4Institut Supérieur d’Electronique de Paris, ISEP, Paris, France *CR, f 6059 — B0070 Investigation of the correlation among diameter of retinal vessel and arteriosclerosis risk factors including hypoadiponectinemia. Kei Homma1, R. Kawasaki2, Y. Tanabe1, K. Saito1, A. Sugano1, A. Hozawa3, K. Takeo4, I. Kubota5, T. Kayama6, H. Yamashita1. 1 Ophthalmology, Yamagata Univ Sch of Medicine, Yamagata, Japan; 2Public Health, Yamagata Univ Sch of Medicine, Yamagata, Japan; 3Tohoku Univ Sch of Medicine, Sendai, Japan; 4Neurology,Hemat ology,Metabolism,Endocrinology and Diabetology, Yamagata Univ Sch of Medicine, Yamagata, Japan; 5Cardiology,Pulmonology,and Nephrology, Yamagata Univ Sch of Medicine, Sendai, Japan; 6 Neurosurgery, Yamagata Univ Sch of Medicine, Yamagata, Japan *CR 6060 — B0071 Noninvasive Imaging of Retinal Pericytes and Endothelial Cells in Living Human Eyes. Toco Y. Chui, T. Gast, S. A. Burns. Optometry, Indiana University, Bloomington, IN 6061 — B0072 Adaptive Optics Measurements of Retinal Arterial Wall Thickness in both Normotensive and Hypertensive Subjects. Jake Hillard1, T. Y. Chui1, D. A. Sapir2, T. Gast1, S. A. Burns1. 1School of Optometry, Indiana University, Bloomington, IN; 2Medical School, Indiana University, Bloomington, IN Thursday Posters 10:30 am – 12:15 pm 6062 — B0073 Distribution of vessels with dark tails in the parafoveal capillary network monitored by adaptive optics scanning laser ophthalmoscopy. Shigeta Arichika, A. Uji, M. Hangai, S. Ooto, N. Yoshimura. Kyoto University, Kyoto, Japan *CR 6063 — B0074 In vivo imaging of Hypertensive Retinopathy using Fluorescence Adaptive Optics Scanning Light Ophthalmoscopy. Michael Dubow1, 2, A. Pinhas1, 2, N. Shah1, Y. N. Sulai3, P. Garcia1, N. K. Scripsema4, J. Carroll5, A. Dubra5, R. B. Rosen1. 1New York Eye and Ear Infirmary, New York City, NY; 2Mount Sinai School of Medicine, Mount Sinai Hospital, New York City, NY; 3 University of Rochester, Rochester, NY; 4New York Medical College, Valhalla, NY; 5Medical College of Wisconsin, Milwaukee, WI *CR 6064 — B0075 Normal retinal vasculature imaged using fluorescence adaptive optics scanning light ophthalmoscopy (FAOSLO). Nishit Shah1, M. Dubow1, 2, A. Pinhas1, 2, N. K. Scripsema1, A. Dubra3, 4, Y. N. Sulai6, 3, D. H. Scoles5, 3, R. B. Rosen1. 1Ophthalmology, New York Eye and Ear Infirmary, New York, NY; 2Mount Sinai Hospital, Mount Sinai School of Medicine, New York, NY; 3Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 4Biophysics, Medical College of Wisconsin, Milwaukee, WI; 5 Biomedical Engineering, University of Rochester, Rochester, NY; 6The Institute of Optics, University of Rochester, Rochester, NY *CR 6065 — B0076 Histopathologic Features of Diabetic Microangiopathy Imaged Using an Adaptive Optics Scanning Laser Fluorescein Angiography. Richard B. Rosen1, 2, A. Dubra3, R. Weitz1, J. Carroll3, M. Dubow1, 4 , A. Pinhas1, 4, N. Shah1, Y. N. Sulai3, 5, N. K. Scripsema1, 2, J. B. Walsh1, 2. 1Ophthalmology, New York Eye & Ear Infirmary, New York, NY; 2 Ophthalmology, New York Medical College, Valhalla, NY; 3Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 4Ophthalmology, Mount Sinai School of Medicine, New York, NY; 5Ophthalmology, University of Rochester, Rochester, NY *CR 6066 — B0077 Microangiopathic Features of Central Retinal Vein Occlusion Imaged Using Fluorescence Adaptive Optics Scanning Light Ophthalmoscopy. Alexander Pinhas1, 2, N. Shah1, M. Dubow1, 2, M. Mehta1, P. Garcia1, N. K. Scripsema1, 3, J. Carroll4, 5, Y. N. Sulai6, A. Dubra4, 7, R. B. Rosen1. 1Ophthalmology, New York Eye and Ear Infirmary, New York, NY; 2Mount Sinai School of Medicine, New York, NY; 3New York Medical College, Valhalla, NY; 4Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 5Cell Biology, Neurology and Anatomy, Medical College of Wisconsin, Milwaukee, WI; 6The Institute of Optics, University of Rochester, Rochester, NY; 7Biophysics, Medical College of Wisconsin, Milwaukee, WI *CR Exhibit Hall B0138-B0179 Thursday, May 09, 2013 10:30 AM-12:15 PM Retinal Cell Biology / Visual Neuroscience 537 Cell Biology of the Retina and RPE II Moderator: Peter F. Hitchcock 6067 — B0138 Increasing body weight correlates with loss of ERG in mice with Bardet Biedl Syndrome. Arlene V. Drack1, S. Bhattarai1, E. M. Stone1, K. Wang3, D. Gratie1, E. Heon2, V. C. Sheffield1, R. F. Mullins1. 1Ophthalmology, Univ of Iowa Hospitals, Iowa City, IA; 2Ophthalmology, Sickkids Toronto, Toronto, ON, Canada; 3 Biostatistics, University of Iowa, Iowa City, IA *CR 6068 — B0139 Enforced Expression of Snail Gene Resulted in Retinal Pigment EpithelialMesenchymal Transition. Hui Li, F. Wang, M. Li. Tenth People’s Hospital of Tongji University, Shanghai, China 6069 — B0140 Effects of thrombin on tight junction-associated molecules in polarized RPE cells. Hiroto Terasaki, M. Shirasawa, H. Otsuka, S. Sonoda, T. Sakamoto. Ophthalmology, Kagoshima University, Kagoshima, Japan 6070 — B0141 Retinal changes in Hemiparkinson rat. Soon Il Kwon1, C. Cho2, I. Kim3. 1ophthalmology, HALLYM Sacred heart HOSPITAL, Hallym University, Anyang, Republic of Korea; 2neurosurgery, HALLYM Sacred heart HOSPITAL, Hallym University, Anyang, Republic of Korea; 3Anatomy, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea 6071 — B0142 Iron Upregulates Melanogenesis Genes in the RPE. Natalie Wolkow1, A. Maminishkis4, J. Iacovelli3, J. C. Lee2, S. S. Miller4, J. L. Dunaief1. 1Scheie Eye Institute, The Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; 2Pennsylvania College of Optometry, Salus University, Elkins Park, PA; 3Schepens Eye Research Institute, Harvard Medical School, Boston, MA; 4National Eye Institute, National Institutes of Health, Bethesda, MD *CR 6072 — B0143 The Role of Glucocorticoid Receptor Signaling in Normal and Damaged Avian Retina. Donika Gallina, A. J. Fischer. The Ohio State University, Columbus, OH 6073 — B0144 Polyvinyl Alcohol-based Encapsulation of Müller Cells Improves Release of Brain-Derived Neurotrophic Factor. Yuko Shinohara, M. Takii, T. Nakamura, M. Nakatani, K. Ohtsuki. Bioengineering Institute, NIDEK Co Ltd, Gamagori, Japan *CR 6074 — B0145 AMPK-NF-κB axis modulates visual function during inflammation. Mamoru Kamoshita1, S. Kubota1, K. Yuki1, S. Miyake1, N. Nagai1, K. Umezawa2, K. Tsubota1, Y. Ozawa1. 1 Ophthalmology, Keio University School of Medicine, Shinjyuku, Japan; 2Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Nagakute, Japan *CR 6075 — B0146 Elastin-like polypeptide (ELP) fused to an αB crystallin mini-chaperone protects RPE cells from oxidant injury. Parameswaran G. Sreekumar1, W. WANG2, J. A. MacKay2, C. Spee3, S. J. Ryan1, 3, R. Kannan1, 3, D. R. Hinton4, 1. 1 Arnold and Mabel Beckman Macular reserach Center, Doheny Eye Institute, Los Angeles, CA; 2 Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA; 3Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA; 4Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 380 Thursday – Posters – 6076 – 6096 6076 — B0147 Rod and Cone Photoreceptors in the Mouse Retina Express Cfh. Sharon L. Oltjen1, J. Estep2, P. G. FitzGerald2, Q. Gong2, L. M. Hjelmeland1. 1Ophthalmology, University of California-Davis, Davis, CA; 2Cell Biology & Human Anatomy, University of California-Davis, Davis, CA *CR 6077 — B0148 Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice. Toshio Narimatsu1, 2, S. Miyake1, S. Kubota3, M. Hirasawa2, N. Nagai1, 2, K. Tsubota2, Y. Ozawa1, 2. 1Laboratory of Retinal Cell Biology, Keio University School of Medicine, Shinjukuku, Japan; 2Department of Ophthalmology, Keio University School of Medicine, Shinjuku-ku, Japan; 3 Ophthalmology and Visual Science, Washington University School of Medicine in St.Louis, St. Louis, MO *CR 6078 — B0149 Age-Dependent Ocular Changes in Sirt6 Knockout Mice. Alexey Obolensky1, V. Peshti2, Y. Kanfi2, H. Y. Cohen2, E. Banin1. 1Center for Retinal and Macular Degenerations, Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; 2The Mina and Everard Goodman Faculty of Life Sciences, BarIlan University, Ramat-Gan, Israel 6079 — B0150 Hyaluronan and Tissue Inhibitor of Metalloproteinases-3 in Sorsby’s Fundus Dystrophy and AMD. Alecia Cutler1, B. Anand-Apte1, V. L. Bonilha1, D. Hatipoglu1, H. Stoehr2. 1Ophthalmic Research, Cleveland Clinic Foundation, Cleveland, OH; 2Institute of Human Genetics, University of Regensburg, Regensburg, Germany *CR 6080 — B0151 Best Vitelliform Macular Dystrophy Mutants Oligomerize with Wild Type Bestrophin-1 and Exhibit Differential Effects on Protein Trafficking. Adiv A. Johnson1, Y. Lee1, K. Yu4, C. H. Hartzell4, L. Y. Marmorstein1, 2, A. D. Marmorstein1, 3. 1Ophthalmology and Vision Science, University of Arizona, Tucson, AZ; 2Department of Physiology, University of Arizona, Tucson, AZ; 3College of Optical Sciences, University of Arizona, Tucson, AZ; 4Department of Cell Biology and Center for Neurodegenerative Disease, Emory University, Atlanta, GA 6084 — B0155 Expression of RPE primary cilia in adult mice. Guillermo L. Lehmann-Mántaras, R. Schreiner, E. de la Fuente, E. J. Rodriguez-Boulan. Ophthalmology, Weill Cornell Medical College, New York, NY 6085 — B0156 Involvement of LC3-dependent phagocytosis and MREG in the degradation of disk membranes by the RPE. Kathleen BoeszeBattaglia1, F. P. Stefano1, V. S. Lopes3, A. Bragin1, B. Jun4, W. C. Gordon4, I. R. Rodriguez2, N. G. Bazan4, D. S. Williams3, L. S. Frost1. 1Biochemistry, University of Pennsylvania, Philadelphia, PA; 2 National Eye Institute, Bethesda, MD; 3Jules Stein Eye Institute- UCLA School of Medicine, Los Angeles, CA; 4Neuroscience, LSUHNO, New Orleans, LA 6086 — B0157 Flow Cytometry Approach to Study NGF and p75 in Retinal Cells from Reeler mice. Bijorn O. Balzamino1, R. Marino2, G. Esposito1, F. Biamonte3, F. Keller2, A. Micera1. 1 Lab Ophthalmology, IRCCS GB Bietti Foundation, Rome, Italy; 2Laboratory of Developmental Neuroscience and Neural Plasticity, University Campus Bio-Medico, Rome, Italy; 3Institute of Histology and Embryology, Catholic University of the Sacred Heart “A. Gemelli”, Rome, Italy 6087 — B0158 Spinules of cone horizontal cells in European sea bass are more numerous in the dorsal and nasal peripheral retina. Are spinules biological detectors to peripheral vision of teleosts? Joaquin De Juan, B. Boughlala, N. Martinez-Ruiz. Dept Biotecnologia, Universidad de Alicante, San Vicente del Raspeig, Spain 6089 — B0160 Hypertension-induced Ang II promotes tube formation via MCP-1/MCPIP induction. Maria E. Marin Castano1, W. Lee1, E. P. Hernandez1, F. Praddaude2, C. Pecher2, S. W. Cousins3. 1Ophthalmology, University of Miami, Miami, FL; 2Physiology and Pharmacology, University Paul Sabatier/INSERM-U 338, Toulouse, France; 3Ophthalmology, Duke University Eye Center, Durham, NC *CR 6090 — B0161 Inflammation Exacerbates Hydroxychloroquine-Induced Retinotoxicity in Human Retinal Pigment Epithelial Cells. Matthew G. Trese1, 2, Y. Li1, H. Gao1, X. Qiao1. 1 Department of Ophthalmology, Henry Ford Health System, Detroit, MI; 2Michigan State University, College of Osteopathic Medicine, Detroit, MI 6091 — B0162 A synaptic scaffold complex unique to horizontal cell processes contacting photoreceptors. Alejandro Vila1, 2, C. M. Whitaker1, J. O’Brien1, 2. 1Dept. of Ophthalmology & Visual Science, Houston, TX; 2The University of Texas Graduate School of Biomedical Sciences, Houston, TX 6092 — B0163 A Surface Proteome of Primary Fetal Human RPE Cells. Jason Silver1, D. R. Riordon2, F. Hua1, O. S. Memon1, A. Maminishkis1, R. L. Gundry3, S. S. Miller1, K. R. Boheler2, K. Bharti1. 1National Eye Institute, National Institutes of Health, Bethesda, MD; 2National Institute of Aging, National Institutes of Health, Bethesda, MD; 3 Medical College of Wisconsin, Milwaukee, WI 6093 — B0164 The Role of 7-Ketocholesteryl Esters on 7KCh-Mediated Cytotoxicity and Inflammation in ARPE-19 cells. Jung W. Lee, J. Huang, I. R. Rodriguez. Mechanisms of Retinal Diseases Section, LRCMB, National Eye Institute/ NIH, Bethesda, MD 6094 — B0165 Blockade of Vascular Endothelial Protein Tyrosine Phosphatase: A Novel Approach to Stabilizing the Retinal Vasculature. Ji-kui Shen1, P. A. Campochiaro1, C. Seidel1, A. Dong1, M. Frye2, J. McClung3, S. F. Hackett1, B. Howard4, D. Vestweber2, K. Peters5. 1 Ophthalmology, Wimer Eye Institute, Baltimore, 6088 — B0159 Functional and molecular MD; 2Department of Cell Biology, Max-Planckcharacterization of ex vivo cultured neuronalInstitute of Molecular Biomedicine, Muenster, and glial- like cells from internal limiting Germany; 3Department of Medicine, Division membrane. Xhevat Lumi1, S. Andjelic1, E. Johnsen2, of Cardiology Duke University Medical Center M. Moe2, M. Hawlina1, G. Petrovski1, 3. 1Eye Durham, Durham, NC; 4Procter & Gamble, Hospital, University Medical Centre, Ljubljana, Cincinnati, OH; 5Aerpio Therapeutics, Cincinnati, Slovenia; 2Centre for Eye Research,Department OH *CR of Ophthalmology, Oslo University Hospital and 6095 — B0166 Optical Coherence Tomography University of Oslo, Oslo, Norway; 3Stem Cells (OCT) and histologic examination of a mouse and Eye Research Laboratory, Departments of model of chorioretinal coloboma. Sajag Bhattarai, Ophthalmology and Biochemistry and Molecular D. Gratie, M. Stunkel, M. G. Anderson, R. F. Biology, Medical and Health Science Center, Mullins, A. V. Drack. University of Iowa, Iowa City, University of Debrecen, Debrecen, Hungary IA *CR 6096 — B0167 Life and Death of Retinal Cells in Optic Nerve Sectioned Chick Eyes. Stacey Chong1, C. F. Wildsoet2, V. Choh1. 1Vision Science, University of Waterloo, Waterloo, ON, Canada; 2 School of Optometry, University of California, Berkeley, Berkeley, CA 6082 — B0153 Structural and Functional Properties of Photoreceptor Mitochondria in Awake and Hibernating Ground Squirrels. Talia R. Kaden1, 2, J. Du1, A. R. Goel1, D. Lu1, W. Li1. 1 Retinal Neurophysiology, NEI, Bethesda, MD; 2 Yale University School of Medicine, New Haven, CT f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 381 Thursday Posters 10:30 am – 12:15 pm 6081 — B0152 Paraoxonase-1 (PON1) in retinal physiology and pathophysiology. Jadwiga Oczos1, 2, B. Kloeckener-Gruissem2, 4, W. Berger2, 3, C. Grimm1, 3. 1Lab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Zurich, Switzerland; 2Institute of Medical Molecular Genetics, University of Zurich, Schwerzenbach, Switzerland; 3Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland; 4Department of Biology, ETH Zurich, Zurich, Switzerland 6083 — B0154 Cross-talk Between Retinal Pigment Epithelial Cells and Mast Cells via Secreted Mediators, Especially Mast Cell Tryptase. Rei Wakasa1, H. Kawano2, A. Matsuda2, H. Ushio3, T. Sakuma1, A. Murakami2, N. Ebihara1. 1 Ophthalmology, Juntendo Uneversity Urayasu Hospital, Urayasu City, Japan; 2Ophthalmology, Juntendo University School of Medicine, Bunkyoku, Japan; 3Allergy Research Center, Juntendo Uneversity School of Medicine, Bunkyo-ku, Japan *CR 6097 – 6115 – Thursday – Posters 6097 — B0168 Physical support of the inner retina enhances cell survival in adult porcine retinal explants. Linnea T. Taylor, K. M. Arner, I. Holmgren Taylor, F. K. Ghosh. Ophthalmology, Lund University, Lund, Sweden 6098 — B0169 Potential phototoxicity of indocyanine green in retinal pigment epithelial cells after its angiography. Tomohito Sato1, Y. Karasawa1, S. Ishikawa1, M. Taguchi1, T. Muraoka1, M. Ito2, M. Takeuchi1. 1Ophthalmology, National Defense Medical College, Tokorozawa, Japan; 2 Developmental Anatomy and Regenerative Biology, National Defense Medical Collage, Tokorozawa, Japan 6099 — B0170 Differential overexpression of Homer 1 isoforms is associated with hallmarks of disease and decline in visual performance in a preclinical model of glaucoma. Simon Kaja1, Y. Naumchuk1, S. L. Grillo1, P. K. Borden1, P. Koulen1, 2. 1Ophthalmology / Vision Research Center, Univ of Missouri-Kansas City, Kansas City, MO; 2Basic Medical Science, Univ of MissouriKansas City, Kansas City, MO 6100 — B0171 Activation of the retinal renin angiotensin system via beta-adrenergic stimulation of renin expression in the RPE. Olaf Strauss1, V. T. Todorov2, J. Stindl3, J. R. Martins4. 1 Experimental Ophthalmology, Charite, University Medicine, Eye Hospital, Berlin, Germany; 2 Nephrology, Inner Medicine III, University Carl Gustav Carus, Dresden, Germany; 3Experimental Ophthalmology, Eye Hospital, University Medicine Regensburg, Regensburg, Germany; 4Institute of cellular and molecular pharmacology, Sophia Antipolis University of Nice, Nice, France Thursday Posters 10:30 am – 12:15 pm 6101 — B0172 Characterization of the blue light toxicity spectrum on A2E-loaded RPE cells in sunlight normalized conditions. Emilie Arnault1, 2, C. Barrau3, C. Nanteau1, 2, P. Gondouin1, 2, V. Fontaine1, 2, T. Villette3, J. A. Sahel2 4 , S. A. Picaud1, 2. 1Institut de la Vision, U968, INSERM, Paris, France; 2Institut de la Vision, UMR_S968, UPMC Université Paris 06, Paris, France; 3Essilor International, Paris, France; 4Centre Hospitalier National d’Ophtalmologie des QuinzeVingts, Paris, France *CR 6102 — B0173 Increased Levels of DJ-1 are present in cells exposed to carboxyethylpyrrole (CEP), and in Retina, RPE, Bruch’s Membrane and Drusen from AMD donor eyes. Vera L. Bonilha, M. E. Rayborn, X. Yang, K. G. Shadrach, J. G. Hollyfield. Ophthalmology, Cole Eye Inst/ Cleveland Clin Lerner Ctr, Cleveland, OH 6103 — B0174 Mechanisms of VEGF upregulation in human RPE cells: Role of oxidized phospholipids and the ATF4 arm of the unfolded protein response. Andreas Pollreisz1, T. Afonyushkin2, O. V. Oskolkova2, F. Gruber3, V. N. Bochkov2, U. Schmidt-Erfurth1. 1Department of Ophthalmology, Medical University Vienna, Vienna, Austria; 2Department of Vascular Biology and Thrombosis Research, Medical University Vienna, Vienna, Austria; 3Department of Dermatology, Medical University Vienna, Vienna, Austria *CR 6104 — B0175 Epithelial Membrane Protein 2 (EMP2) Modulates VEGF During Hypoxia in ARPE-19 Cells. Ann M. Chan1, S. A. Morales1, Y. Qin1, M. Wadehra2, L. K. Gordon1. 1Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA; 2Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA *CR 6105 — B0176 Identification of Interacting Protein Partners of TOPORS in the Retina. Barbara Czub1, A. Z. Shah1, G. Alfano1, L. Valdés Sánchez2, C. Chakarova1, S. S. Bhattacharya1, 2. 1 Genetics, UCL Institute of Ophthalmology, London, United Kingdom; 2Cellular Therapy and Regenerative Medicine, Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER), Seville, Spain f 6106 — B0177 Conditional Depletion of Retinal VLC-PUFAs Causes Retinal Dysfunction. Martin-Paul G. Agbaga1, 4, B. Hopiavuori3, 4, F. Li1, 4, J. McRae1, 4, R. S. Brush1, 4, M. A. Mandal1, 3, L. D. Marchette1, 2, M. H. Elliott1, 3, R. Ayyagari5, R. E. Anderson1, 2. 1Ophthalmology, Univ of Oklahoma Hlth Sci Ctr, Oklahoma City, OK; 2Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK; 3Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK; 4Dean McGee Eye Institute, Oklahoma City, OK; 5ophthalmology, Shiley Eye Center, University of California, San Diego, CA *CR 6107 — B0178 Inhibition of retinoblastoma tumor progression using catalytic antioxidant naoparticles. Kathryn E. Klump1, R. Towner3, 1, S. Seal6, 5, M. Dyer4, J. F. McGinnis2, 1. 1Oklahoma Ctr for Neuroscience, Univ of Oklahoma Hlth Sciences Ctr, Oklahoma City, OK; 2Cell Biology, Ophthalmology, Univ of Oklahoma Hlth Sciences Ctr, Oklahoma City, OK; 3Oklahoma Medical Research Foundation, Oklahoma City, OK; 4 Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN; 5Mechanical Materials and Aerospace Engineering, University of Central Florida, Orlando, FL; 6Nanoscience and Technology Ctr, University of Central Florida, Orlando, OK *CR 6108 — B0179 Independent roles of methionine sulfoxide reductase A in mitochondrial ATP synthesis and in protection from oxidative stress of the retinal pigment epithelium. Silvia C. Finnemann, J. Vargas, Y. Dun. Biological Sciences, Fordham University, Bronx, NY Exhibit Hall B0180-B0189 Thursday, May 09, 2013 10:30 AM-12:15 PM Biochemistry/Molecular Biology 538 Apoptosis and Cell Stress Moderator: Nichole D. Joachim 6109 — B0180 Rag1 expression in RGCs is involved in programmed cell death. Takao Hirano1, T. Hayashi2, T. Murata1. 1Depart of Ophthalmology, Shinshu University, Matsumoto, Japan; 2Department of Molecular and Cellular Immunology, Shinshu University, Matsumoto, Japan 6110 — B0181 Apoptotic retinal ganglion cell death in an autoimmune glaucoma model is accompanied by antibody depositions. Stephanie C. Joachim1, C. Mondon1, S. Kuehn1, S. Reinehr1, F. H. Grus2, B. H. Dick1. 1Experimental Eye Research Institute, Ruhr University, Bochum, Germany; 2 Experimental Ophthalmology, University Medical Center, Mainz, Germany 6111 — B0182 Epigenetic Regulation of Rod Photoreceptor Development. Sarah Cheng, H. Yang, A. Swaroop. N-NRL, Bldg 6, National Eye Institute, Bethesda, MD 6112 — B0183 Histone Deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury. Heather Schmitt1, 2, C. Schlamp1, R. W. Nickells1. 1 Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI; 2Cellular and Molecular Pathology, University of WisconsinMadison, Madison, WI 6113 — B0184 Dicer is required for survival of mature rod photoreceptors. Thomas Sundermeier1, N. Zhang1, D. Mustafi1, H. Kohno2, K. Palczewski1. 1Pharmacology, Case Western Reserve University, Cleveland, OH; 2Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH *CR 6114 — B0185 Transient Upregulation and then Downregulation of BACE 1 and PS-1 in ER Stress Induced Apoptosis of Retinal Ganglion Cells in vitro. Bingqian Liu, J. Ge. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China 6115 — B0186 Progranulin Mutant Mice Exhibit Accumulation of Intraneuronal Lipofuscin Aggregates in the Retina. Brian P. Hafler1, Z. A. Klein2, S. Strittmatter2. 1 Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT; 2Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale School of Medicine, New Haven, CT The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 382 Thursday – Posters – 6116 – 6138 6116 — B0187 C1qa deficiency exacerbates RGC loss in a mouse glaucoma model. Qiong Ding1, M. G. Anderson2, A. Cook1, M. H. Kuehn1. 1 Ophthalmology and Visual Sciences, U of Iowa, Iowa City, IA; 2Molecular Physiology and Biophysics, U of Iowa, Iowa City, IA 6117 — B0188 Unveiling the retina’s realm with retinal oxygenation. Veronica A. Kon Graversen, M. Landers. Retina, University of North Carolina at Chapel Hill, Chapel Hill, NC 6118 — B0189 RNA Structure-Function Issues in Realizing Catalytically-Active Hammerhead Ribozymes in Cells. Jack M. Sullivan1, 2, T. A. Kolniak3. 1Research Service, Veterans Administration Western NY Healthcare System, Buffalo, NY; 2Ophthalmology, Pharm/Tox, Phys/ Biopys, SUNY Eye Institute, SUNY at Buffalo, Buffalo, NY; 3Program in Neuroscience, SUNY at Buffalo, Buffalo, NY *CR Exhibit Hall B0190-B0215 Thursday, May 09, 2013 10:30 AM-12:15 PM Visual Neuroscience / Visual Psychophysics / Physiological Optics 539 Advancing Functional Assessment of the Visual System Moderator: Paul J. DeMarco 6119 — B0190 L:M Cone Ratio of Japanese Derived with ERG Flicker Photometry Method. Yasuki Yamauchi1, K. Yatsu1, J. A. Kuchenbecker2, M. Neitz2, J. Neitz2. 1Dept. Informatics, Yamagata University, Yonezawa, Japan; 2Dept. Ophthalmology, University of Washington Medical School, Seattle, WA *CR 6120 — B0191 Change in Flash Electroretinogram Morphology from Scotopic to Photopic Conditions. Kate A. Godwin, P. J. DeMarco. Psychological & Brain Sciences, University of Louisville, Louisville, KY 6121 — B0192 Dark-adapted 15-Hz Flicker Electroretinograms Measured With Rodisolating Stimuli. Swetha Dhanireddy1, J. C. Park2, P. R. Nolan2, D. Cao2, J. McAnany2. 1American University of Antigua, St. Johns, Antigua and Barbuda; 2Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 6124 — B0195 High throughput testing of absolute behavioral threshold in mice. Charles P. Ratliff, L. Faktorovich, A. P. Sampath. Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 6125 — B0196 Electrical measurements of pigment bleaching in vivo. Christopher Kessler1, E. N. Pugh1, 2, M. E. Burns1, 3. 1Center for Neuroscience, UC Davis, Davis, CA; 2Human Anatomy and Cell Biology, UC Davis, Davis, CA; 3 Ophthalmology & Vision Science, UC Davis, Davis, CA 6126 — B0197 Contributions of Non-Visual Sensory Signals to the Murine Flash ERG. Naoyuki Tanimoto1, V. Sothilingam1, G. Gloeckner1, E. Bryda2, P. Humphries3, M. Biel4, M. W. Seeliger1. 1 Division of Ocular Neurodegeneration, Institute for Ophthalmic Research, Centre for Ophthalmology, Tuebingen, Germany; 2Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO; 3Ocular Genetics Unit, Trinity College Dublin, Dublin, Ireland; 4Department of Pharmacy, Center for Integrated Protein Science Munich, LudwigMaximilians Universitaet Muenchen, Munich, Germany 6127 — B0198 Impact of the spectral output of “white” LEDs on the murine flash ERG. Mathias W. Seeliger1, K. Narfstrom2, N. Tanimoto1. 1 Div of Ocular Neurodegeneration, Ctr Ophthal Inst Ophthalmic Rsrch, Tuebingen, Germany; 2Dept of Vet Med & Surgery, University of Missouri, Columbia, MO 6128 — B0199 Comparison of transretinal mouse rod ERG with local ERG across photoreceptor outer segments. Teemu T. Turunen, A. O. Koskelainen. Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Espoo, Finland 6129 — B0200 Adapting Commercial In Vivo Electroretinogram System for Ex Vivo Recordings. Vladimir J. Kefalov, F. Vinberg. Ophthalmology & Visual Sciences, Washington University School of Medicine, Saint Louis, MO 6130 — B0201 Voltage-gated sodium channels amplify both light and dark adapted electroretinograms in mice. Ben Smith, P. D. Cote, F. Tremblay. Dalhousie University, Halifax, NS, Canada 6131 — B0202 Binocular pattern electroretinograms in the mouse. Tsung-Han Chou1, 2, J. A. Toft-Nielsen2, J. E. Bohorquez2, O. Ozdamar2, V. Porciatti1. 1Bascom Palmer Eye Inst, Univ of Miami, Miller Sch of Med, Miami, FL; 2 Biomedical Engineering, University of Miami, Miami, FL 6132 — B0203 Recording and Manipulation of the Pattern Electroretinogram in a Mouse Eyecup Preparation. Eric C. Gustafson, A. L. Silberschmidt, M. Esguerra, R. F. Miller. Neuroscience, University of Minnesota, Minneapolis, MN 6133 — B0204 Spatial differences in corneal potentials in healthy rat eyes evaluated with multi-electrode electroretinography (meERG). John R. Hetling, H. Tajalli, Y. Krakova, Z. Derafshi. Bioengineering, University of Illinois at Chicago, Chicago, IL *CR 6134 — B0205 Multifocal Electroretinography with simultaneous fundus imaging in mice. R Michael Dutescu1, S. Skosyrski1, N. Kociok1, I. Semkova1, S. Mergler1, J. Atorf2, A. M. Joussen1, J. J. Kremers2. 1Ophthalmology, Charité-Universitätsmedizin, Berlin, Germany; 2 Ophthalmology, University Hospital Erlangen, Erlangen, Germany *CR 6135 — B0206 Topography and aging of the scotopic mfERG. Athanasios Panorgias1, E. E. Sutter2, J. S. Werner1, 3. 1Ophthalmology & Vision Science, University of California Davis, Sacramento, CA; 2Electro-Diagnostic Imaging Inc, Redwood City, CA; 3Neurobiology, Physiology and Behavior, University of California Davis, Davis, CA *CR 6136 — B0207 Slow flash multifocal electroretinograms in the foveola. Yoshiaki Shimada1, A. Nakamura2, A. Tanikawa2, M. Horiguchi2. 1Ophthalmology, Fujita Health Univ Banbuntane Hosp, Nagoya, Japan; 2Ophthalmology, Fujita Health Univ School of Medicine, Toyoake, Japan 6137 — B0208 Validation of a Novel Fast and Robust Automated Technique for Calculation of the EOG Arden Ratio, Using R. Marc Sarossy1, 3, M. H. Lee2, M. Bach4. 1ODC, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia; 2 Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia; 3 CERA, University of Melbourne, Melbourne, VIC, Australia; 4Universitäts-Augenklinik, Freiburg, Germany 6138 — B0209 The Uncertainty Classifier: Use of a Novel Statistical Classifier with Fuzzy Classification Boundaries to Evaluate Performance of Automated Electrooculogram (EOG) testing. Matthew H. Lee1, M. Sarossy2, M. Triglia3. 1Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia; 2Ocular Diagnostic Clinic, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia; 3Victorian Institute of Forensic Mental Health, Clifton Hill, VIC, Australia f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 383 Thursday Posters 10:30 am – 12:15 pm 6122 — B0193 Recovery of human rod photoreceptors following prolonged illumination, assessed using the electroretinogram. Omar A. Mahroo1, 2, R. Sakalauskaite2, C. J. Hammond1, T. D. Lamb3. 1Ophthalmology, King’s College London, London, United Kingdom; 2Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom; 3 Department of Neuroscience, John Curtin School of Medical Research and ARC Centre of Excellence in Vision Science, Australian National University, Canberra, ACT, Australia 6123 — B0194 The Spatial Distribution of L- and M-Cone Driven ERGs Reflecting Parvoand Magnocellular Activity. Bruno D. Gomes1, G. S. Souza1, 2, M. D. Filho1, G. Pangeni3, L. L. Silveira1, 2, J. J. Kremers3. 1Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil; 2Nucleo de Medicina Tropical, Univerdidade Federal do Para, Belem, Brazil; 3Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany 6139 – 6164 – Thursday – Posters 6139 — B0210 Chromatic pseudo-random VECP: spatial frequency tuning and visual acuity estimative. Givago S. Souza1, 2, I. V. Martins1, B. D. Gomes1, L. L. Silveira1, 2. 1Insituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil; 2Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil 6140 — B0211 Optimization of Check Size and Contrast on the Visual-Evoked Potential (VEP) in Visually-Normal Individuals. Naveen K. Yadav, K. J. Ciuffreda. Vision Sciences, SUNY, College of Optometry, New York, NY 6141 — B0212 Macular pigment-based luminance artifacts do not account for band-pass temporal tuning of the chromatic visual evoked potential (cVEP). Rafal M. Skiba, C. S. Duncan, C. Jones, A. M. Jackson, M. A. Crognale. Psychology, University of Nevada, Reno, Reno, NV 6142 — B0213 Chromatic and achromatic contribution to the multifocal visual evoked potentials. Monique Smyth4, 3, C. G. Kilemi6, 3, G. S. Souza1, 2, C. D. Araujo2, E. C. Lacerda2, M. M. Jacob2, B. D. Gomes2, M. E. Fitzgerald3, 5, L. L. Silveira1, 2. 1Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Brazil; 2 Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Brazil; 3Christian Brothers University, Memphis, TN; 4Rhodes College, Memphis, TN; 5University of TN Health Science Center, Memphis, TN; 6Coppin State University, Baltimore, MD 6143 — B0214 Effect of Test Duration on the Visual-Evoked Potential (VEP) and Alpha Wave Responses. Kevin T. Willeford, N. K. Yadav, K. J. Ciuffreda. SUNY State College of Optometry, New York, NY 6144 — B0215 Effect of Simulated Octant Visual Field Defects on the Visual-Evoked Potential (VEP). Diana P. Ludlam, N. K. Yadav, K. J. Ciuffreda. Vision Sciences, SUNY College of Optometry, New York, NY Exhibit Hall B0216-B0235 Thursday, May 09, 2013 10:30 AM-12:15 PM Visual Neuroscience 540 Bipolar and Horizontal Cells Thursday Posters 10:30 am – 12:15 pm Moderator: Bart G. Borghuis 6145 — B0216 Tetraphasic Horizontal Cell in the Retina of Goldfish. Kenkichi Fukurotani. Faculty of Engineering, University of Toyama, Toyama, Japan 6157 — B0228 Two Distinct Patterns of Input Exist Among ON Cone Bipolar Cells and Predict Their Spatial Responding. Robert Purgert, P. D. Lukasiewicz. Washington University in St. Louis School of Medicine, St. Louis, MO 6146 — B0217 Presence of the Gpr179nob5 mutation in C3H-derived transgenic mice. Jasmin Balmer1, 2, R. Ji3, R. G. Gregg3, N. S. Peachey4, V. Enzmann1. 1Department of Ophthalmology, University of Berne, Berne, Switzerland; 2 Graduate School for Cellular and Biomedical Sciences, University of Berne, Berne, Switzerland; 3 Department of Biochemistry & Molecular Biology, University of Louisville, Louisville, KY; 4 Department of Ophthalmic Research, Cleveland Clinic, Cleveland, OH 6147 — B0218 The luminal and spatiotemporal dependence of mouse optokinetic contrast sensitivity on rod pathway components. Cameron Cowan1, M. E. van der Heijden2, E. M. Lo2, D. Paul4, J. Lem3, D. E. Bramblett5, S. M. Wu2. 1Neuroscience, Baylor College of Medicine, Houston, TX; 2Ophthalmology, Baylor College of Medicine, Houston, TX; 3Ophthalmology, Tufts Medical Center, Boston, MA; 4Neurobiology, Harvard University, Boston, MA; 5Medical Education, Texas Tech UHSC, El Paso, TX 6148 — B0219 Intracellular calcium acts on two separate targets to reduce the gain mGluR6 signaling in rod bipolar cells. Katherine Fehlhaber, A. P. Sampath. Neuroscience, University of Southern California, Los Angeles, CA 6154 — B0225 Adaptation to background light permits contrast coding at rod bipolar cell synapses. Jiangbin Ke1, Y. V. Wang2, M. S. Cembrowski4, H. Riecke5, W. L. Kath5, 6, J. B. Demb2, 3, J. H. Singer1. 1Department of Biology, University of Maryland, College Park, MD; 2 Department of Cellular and Molecular Physiology, Yale University, New Haven, CT; 3Department of Ophthalmology and Visual Science, Yale University, New Haven, CT; 4Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA; 5Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, IL; 6Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 6155 — B0226 Quantifying the Effect of Light Activated Outer and Inner Retinal Inhibitory Pathways on Exocytosis from Mixed Bipolar Cells. Mikhail Y. Lipin, J. Vigh. Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 6156 — B0227 Cell type-specific Synaptic Connections of Bipolar and Ganglion Cells in the Mouse Retina. Sonja Neumann, L. Hüser, S. Haverkamp. Max Planck Institute for Brain Research, Frankfurt am Main, Germany 6149 — B0220 Metabotropic glycine receptors can enhance bipolar cell output in rat retina. Jay Garaycochea, M. Slaughter, J. Myers. Neuroscience, University at Buffalo, Buffalo, NY 6158 — B0229 CaV3.1 (T-Type) Calcium Channels in Bipolar Cells of the Macaque Retina. Theresa Puthussery, J. Gayet, W. R. Taylor. Ophthal-Casey Eye Inst, Oregon Health & Science Univ, Portland, OR 6150 — B0221 Possible roles of glutamate transporter EAAT5 in mediating mouse cone on-bipolar cell light responses. Dennis Y. Tse1, I. Chung1, 2, S. M. Wu1. 1Ophthalmology, Baylor College of Medicine, Houston, TX; 2 Ophthalmology, Gyeongsang National University, Jinju, Republic of Korea 6159 — B0230 CACNA1S expression, structure and function in retinal depolarizing bipolar cells. Thomas A. Ray1, N. Hasan1, M. A. McCall2, R. G. Gregg1. 1Biochemistry & Molecular Biology, University of Louisville, Louisville, KY; 2 Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 6151 — B0222 Modeling of electroretinography b-wave amplitudes validates a critical role of tonic GABAC receptor-carried chloride currents in sensitizing and light adapting rod bipolar cell light responses. Rolf Herrmann1, 2, B. Lee2, E. C. Solessio3, V. Y. Arshavsky2. 1Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 2 Ophthalmology, Duke University, Durham, NC; 3Ophthalmology, SUNY Upstate Medical University, Syracuse, NY 6160 — B0231 Contribution of RGS proteins to the light responses of ON-bipolar neurons. Ignacio Sarria, K. A. Martemyanov. Neuroscience, The Scripps Research Institute, Jupiter, FL 6152 — B0223 Ca2+ and Ca2+-activated Clcurrents of Presynaptic Terminals of Bipolar Cells: A Comparative Study on Mouse and Goldfish Retinas. Ji Hyun Jeon, S. Paik, I. Kim. Department of Anatomy, The Catholic University of Korea, Seoul, Republic of Korea 6153 — B0224 Temporal Filtering in Cone Bipolar Cells in the Mouse Retina is Partially Subtype Specific. Tomomi Ichinose1, 2, J. A. Cohn2. 1 Anatomy & Cell Biology / Ophthalmology, Wayne State Universtiy School of Medicine, Detroit, MI; 2 Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, MO 6161 — B0232 The role of ionotropic glutamate receptors in dopamine-induced, GABA-driven rod bipolar cell sensitization. Amanda M. Travis1, S. J. Heflin2, R. Herrmann2, V. Y. Arshavsky2, 1. 1 Pharmacology, Duke University, Durham, NC; 2 Ophthalmology, Duke University, Durham, NC 6162 — B0233 The Effect of PKCα on the Electroretinogram. Wei-Hong Xiong, M. TekmenClark, S. Lolich, R. M. Duvoisin, C. W. Morgans. Physiology & Pharmacology, Oregon Health & Science University, Portland, OR 6163 — B0234 Steady-state Ca modulates rod bipolar cell exocytosis. Qun-Fang Wan, H. Ruth. Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX 6164 — B0235 Abnormalities of retinal synaptic ribbons induced by L-AP4. Jun Zhang, N. Oesch, J. Diamond. Synaptic Physiology Section, NINDS/NIH, Bethesda, MD The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 384 Thursday – Posters – 6165 – 6179 Exhibit Hall C0050-C0100 Thursday, May 09, 2013 10:30 AM-12:15 PM Genetics / Visual Neuroscience 541 Genetic Risk Factors for Common Eye Disorders with Complex Inheritance Moderators: Stephanie A. Hagstrom and Margaret A. Pericak-Vance 6165 — C0050 Is AMD a Disease or a Disorder? A Systems Biology Attempt to Subtype AMD on the Basis of Gene Expression. Mones S. Abu-Asab1, C. Chan2, 1. 1Histopathology Core, National Eye Institute, Bethesda, MD; 2Laboratory of Immunology, National Eye Institute, Bethesda, MD 6166 — C0051 Population Attributable Risk of Known AMD Genetic Risk Factors Based on the 1000 Genomes Project. Joe M. Butler1, Y. C. Yang2, L. I. Paraoan1. 1Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom; 2 Ophthalmology, Wolverhamptom Med Inst-New Cross, Wolverhamptom, United Kingdom *CR 6167 — C0052 Association of PTX3 polymorphisms with age-related macular degeneration and polypoidal choroidal vasculopathy. Jianhuan Chen1, 2, H. Chen1, W. Chen1, M. Zhang1, C. Pang1, 2. 1Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou, China; 2 The Chinese University of Hong Kong, Hong Kong, China 6170 — C0055 Association of Family History with Genetic Risk Factors in Patients with Age-Related Macular Degeneration. Nicole T. Saksens1, Y. T. Lechanteur1, S. K. Verbakel1, J. M. Groenewoud2, C. J. Boon1, 3, A. I. Den Hollander1, 4, C. B. Hoyng1. 1Ophthalmology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; 2 Epidemiology, Biostatistics and Health Technology Assessment, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; 3Oxford Eye Hospital, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; 4Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands 6171 — C0056 Interaction analysis of exogenous estrogen in age-related macular degeneration (AMD) finds novel associations within the VEGF, Complement, and TGFB pathways. Monique D. Courtenay1, W. Cade1, S. G. Schwartz2, J. L. Kovach2, A. Agarwal3, G. Wang1, J. L. Haines4, M. A. Pericak-Vance1, W. K. Scott1. 1Hussman Institute of Human Genomics, University of Miami, Miami, FL; 2Bascom Palmer Eye Institute, University of Miami, Miami, FL; 3 Ophthalmology, Vanderbilt University, Nashville, TN; 4Center for Human Genetics Research, Vanderbilt University, Nashville, TN *CR 6172 — C0057 Genetic interaction mapping of AMD identifies potential gene-disease associations. Lee Kiang, J. Huang, R. E. Tsuchida, K. T. Jayasundera. Kellogg Eye Center, University of Michigan, Ann Arbor, MI 6173 — C0058 Cfh genotype interacts with dietary glycemic index to modulate early agerelated macular degeneration-like features in mice. Sheldon Rowan1, K. Weikel1, M. Chang1, B. Nagel2, J. Thinschmidt3, M. B. Grant3, S. J. Fliesler4, 5, D. Smith1, A. Taylor1. 1Human Nutrition Research Center on Aging, Tufts University, Boston, MA; 2Department of Pathology, Saint Louis University, Saint Louis, MO; 3Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL; 4Research Service, VAWNYHS, Buffalo, NY; 5Departments of Ophthalmology & Biochemistry, SUNY-Buffalo & SUNY Eye Institute, Buffalo, NY 6174 — C0059 Overexpression of HtrA1 and Smoking Evokes Choroidal Neovascularization and Retinal Deposit in Aged Mice. Mao Nakayama, D. Iejima, M. Akahori, T. Iwata. National Institute of Sensory organs, Nat’l Hosp Org Tokyo Med Ctr, Tokyo, Japan 6175 — C0060 Contribution of CFH Y402H polymorphism and CFHR3/CFHR1 deletion to age-related macular degeneration in Brazil. Monica B. Melo1, D. D. Sacconi1, G. Ananina1, F. E. Hirata2, P. H. Rim2, A. M. Torigoe2, M. J. Silva1, J. C. Vasconcellos2. 1CBMEG, University of Campinas, Campinas, Brazil; 2Ophthalmology, University of Campinas, Campinas, Brazil 6176 — C0061 Novel CFH variants in patients with age-related macular degeneration. Maheswara R. Duvvari1, J. P. van de Ven1, E. B. Volokhina2, N. T. Saksens1, C. J. Boon1, L. H. Hoefsloot3, L. van den Heuvel2, C. B. Hoyng1, A. I. Den Hollander1, 3. 1Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Pediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 3 Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands 6177 — C0062 Targeted Sequencing, Augmented with Public Resources, Identifies a Rare C3 Allele Associated with Large Risk of Age-related Macular Degeneration. Xiaowei Zhan1, 2, D. E. Larson3, 4, R. S. Fulton3, 4, C. Wang5, D. Stambolian6, E. Y. Chew7, E. Mardis3, 4, A. Swaroop7, G. Abecasis1, 2. 1Biostatistics, University of Michigan, Ann Arbor, MI; 2Center of Statistical Genetics, University of Michigan, Ann Arbor, MI; 3 The Genome Institute, Washington University, St. Louis, MO; 4Department of Genetics, Washington University, St. Louis, MO; 5Department of Biostatistics, Harvard University, Boston, MA; 6 Department of Ophthalmology and Human Genetics, University of Pennsylvania, Philadelphia, PA; 7National Eye Institute, Bethesda, MD *CR 6178 — C0063 Three New Genetic Loci (R1210C mutation in CFH, SNPs in COL8A1 and RAD51B) are Related to Progression to Advanced Stages of Age-Related Macular Degeneration. Johanna M. Seddon1, 2, R. Reynolds1, Y. Yu1, S. Raychaudhuri3, 4, B. Rosner5. 1 Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA; 2Ophthalmology, Tufts University School of Medicine, Boston, MA; 3Divisions of Rheumatology and Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; 4 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Boston, MA; 5 Channing Laboratory, Boston, MA *CR 6179 — C0064 Investigating Age-related Macular Degeneration in the Amish. Joshua D. Hoffman1, L. D’Aoust1, L. Jiang1, R. Laux1, A. Agarwal3, W. K. Scott2, M. A. Pericak-Vance2, J. L. Haines1. 1Ctr for Human Genetics Resrch, Vanderbilt Univ Medical Center, Nashville, TN; 2Hussman Institute for Human Genomics, University of Miami, Miami, FL; 3Ophthalmology, Vanderbilt Univ Medical Center, Nashville, TN *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 385 Thursday Posters 10:30 am – 12:15 pm 6168 — C0053 Genetic determinants of Age-related Macular Degeneration in Diverse Populations: the Population Architecture using Genomics and Epidemiology (PAGE) Study. Nicole Restrepo1, T. Garrett2, P. Buzkova3, R. A. Jensen3, B. E. Klein4, R. Klein4, T. Wong5, E. Tai6, D. Crawford1. 1Center for Human Genetics Research, Vanderbilt University, Nashville, TN; 2Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, NC; 3Department of Biostatistics, University of Washington, Seattle, WA; 4Office of Population Genomics, National Human Genome Research Institute, Bethesda, MD; 5Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI; 6 Singapore Eye Research Institute, Singapore national Eye Centre, Singapore, Singapore *CR 6169 — C0054 Association between δ-sarcoglycan gene (SGCD) polymorphisims and age-related macular degeneration (AMD) in Mexican patients. Javier F. Estrada1, A. B. Luna-Angulo1, L. G. Cortes-Ballinas1, R. CoralVázquez2, A. Rendon4, D. C. Guadarrama5, H. Rangel-Villalobos3, J. C. Zenteno5. 1Biochemistry and Molecular Biology, Universidad Panamericana, México, Mexico; 2seccion de estudios de posgrado e investigacion.Escuela de Medicina IPN, IPN, Mexico, Mexico; 3genetica, Unioversidad de Guadalajara, Guadalajara, Mexico; 4Centre de Recherche, Institut de la Vision, Paris, France; 5 Genética, Instituto de oftalmología Conde de Valenciana, Mexico, Mexico 6180 – 6196 – Thursday – Posters 6180 — C0065 Genetic Risk Score Predicts of Severity of Age-related Macular Degeneration. Jonathan L. Haines1, A. Agarwal1, J. N. Cooke Bailey1, J. D. Hoffman1, J. McGrath1, L. M. Olson1, J. L. Kovach2, S. G. Schwartz2, W. K. Scott3, M. A. Pericak-Vance3. 1Ctr Human Genetics Res-Med Ctr, Vanderbilt University, Nashville, TN; 2Bascom Palmer Eye Institute, Naples, FL; 3Human Genetics, University of Miami, Miami, FL *CR 6181 — C0066 The association of elastin gene variants with two angiographic subtypes of polypoidal choroidal vasculopathy. Shigeru Honda, S. Yanagisawa, A. Miki, W. Matsumiya, A. Negi. Kobe University Graduate School of Medicine, Kobe, Japan 6182 — C0067 Associations of C3 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. Ke Liu, L. Chen, P. Tam, C. Pang. Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China 6183 — C0068 Polymorphisms association of CFH, BF, C3, FHR 1-3 and ARMS2 genes with geographic atrophy progression in AgeRelated Macular Degeneration. Sergio Recalde, P. Fernandez, L. Garcia-Garcia, J. M. Caire, A. I. Hernández, V. Fernandez-Garcia, M. MorenoOrduña, A. Garcia-Layana. Ophthalmology, Universidad de Navarra, Pamplona, Spain Thursday Posters 10:30 am – 12:15 pm 6184 — C0069 Genotype Analysis for Single Nucleotide Polymorphisms Profile of Eyes with Vascularized Pigment Epithelial Detachment due to AMD. Clement K. Chan1, 2, D. Sarraf3, P. Abraham4, D. H. Nguyen5, S. G. Lin1, M. Lalezary1, K. Zhang5, 6. 1Vitreoretina, Southern California Desert Retina Consultants, Palm Desert, CA; 2 Department of Ophthalmology, Loma Linda University, Loma Linda, CA; 3Retinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA; 4Retina Section, Black Hills Regional Eye Institute, Rapid City, SD; 5Department of Ophthalmology, University of California, San Diego, San Diego, CA; 6Institute of Genomic Medicine, Shiley Eye Center, University of California, San Diego, San Diego, CA *CR, f 6185 — C0070 Pharmacogenetic associations in neovascular age-related macular degeneration. Results from the IVAN study. Andrew J. Lotery1, 2, J. Gibson3, A. J. Cree1, S. M. Downes4, S. P. Harding5, C. Rogers6, B. C. Reeves6, S. Ennis3, U. Chakravarthy7. 1Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; 2Southampton Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; 3Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; 4Oxford Eye Hospital, Oxford University Hospitals NHS Trust, Oxford, United Kingdom; 5Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom; 6School of Clinical Sciences, University of Bristol, Bristol, United Kingdom; 7 The Institute for Ophthalmology and Vision Science, The Queen’s University of Belfast, Belfast, United Kingdom *CR, f 6186 — C0071 The Role of Genetics in Response to Anti-VEGF Therapy for Wet AMD. Jaclyn L. Kovach1, A. Agarwal2, S. G. Schwartz1, M. A. Brantley2, W. Cade3, J. L. Haines4, M. A. PericakVance3. 1Ophthalmology, Bascom Palmer Eye Institute, Naples, FL; 2Ophthalmology, Vanderbilt Eye Insitute, Nashville, TN; 3Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL; 4Human Genetics, Vanderbilt University School of Medicine, Nashville, TN *CR 6187 — C0072 VEGF-A and VEGFR-2 Gene Polymorphisms and Response to Anti-VEGF Therapy in the Comparison of AMD Treatments Trials (CATT). Stephanie A. Hagstrom1, 2, G. Ying3, G. J. Pauer1, G. M. Sturgill-Short1, J. Huang3, M. G. Maguire3, D. F. Martin1. 1Cole Eye Institute, Cleveland Clinic, Cleveland, OH; 2 Ophthalmology, Cleveland Clinic Lerner College of Case Western Reserve University, Cleveland, OH; 3Ophthalmology, University of Pennsylvania, Philadelphia, PA *CR, f 6188 — C0073 Enhancer elements show enrichment for AMD-associated genetic variants. Lakshmi P. Pulagam1, N. J. Morris1, P. Benchek1, P. Scacheri2, S. K. Iyengar1, 2. 1Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH; 2Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 6189 — C0074 Early Biomarkers of AMD (EBAMD) Study - Design and Baseline Data: IRB-11-5677. Steven G. Pratt1, S. P. Richer2, C. Perry1, 3, G. Ruteledge4, C. Podella2. 1Scripps Health/Scripps Memorial Hospital/Scripps Mericos Eye Institute/Scripps Clinical Research Service, La Jolla, CA; 2Eye Clinic, Capt James A Lovell FHCC, North Chicago, IL; 3Ophthalmology, University of Iowa, Iowa City, IA; 4Biology, University of California, Irvine, CA f 6190 — C0075 Association of the SOD activity, rs1061170 in CFH and rs1531289 in VEGFR2 with protein levels in North Indian age related macular degeneration patients. Neel Sharma1, A. Gupta2, S. Prabhakar1, R. Singh2, S. Sharma3, A. Anand1. 1Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India; 2Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India; 3Statistics, Panjab University, Chandigarh, India 6191 — C0076 AMD-associated variants at chromosome 10q26 locus and ARMS2/ HTRA1gene expression. Gaofeng Wang1, B. Court1, P. Gay1, S. R. Dubovy2, J. L. Kovach2, S. G. Schwartz2, A. Agarwal3, W. K. Scott1, J. L. Haines4, M. A. Pericak-Vance1. 1Hussman Inst for Human Genomics, Univ of Miami Miller Sch of Med, Miami, FL; 2Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 3Ophthalmology, Vanderbilt University, Nashville, TN; 4Center for Human Genetics Research, Vanderbilt University, Nashville, TN *CR 6192 — C0077 Differential gene expression of RPE and choroid in old Cfh transgenic mice. Cynthia X. Wang, B. Aredo, X. Chen, R. UfretVincenty. Ophthalmology, UTSW Medical Center, Dallas, TX 6193 — C0078 GSTM1 and GSTM5 Polymorphisms and Expression in AMD. Allan A. Hunter, Z. Smit-McBride, R. Anderson, E. Kim, S. S. Park, L. M. Hjelmeland, L. S. Morse. Ophthalmology, University of California, Davis, Sacramento, CA *CR 6194 — C0079 Mitochondrial DNA Heteroplasmy in Retinas of AMD Patients. Hui Cai1, P. L. Nagy2, R. Allikmets1, 2. 1Ophthalmology, Columbia University Medical Center, New York, NY; 2Pathology & Cell Biology, Columbia University Medical Center, New York, NY 6195 — C0080 Comparison Between Haplogroup H and L Cybrids in ROS/RNS Production and Gene Expression Further step in understanding the pathogenesis of Age-related Macular Degeneration. Mohamed Tarek1, J. Cáceres del Carpio1, C. A. Ramirez1, P. Falatoonzadeh1, S. Atilano1, D. Malik1, S. Jazwinski2, M. V. Michael2, B. D. Kuppermann1, C. M. Kenney1. 1Gavin Herbert Eye Institute, Irvine, CA; 2Tulane Center For Aging, Tulane University, New Orleans, LA *CR 6196 — C0081 Genetic Testing for AgeRelated Macular Degeneration in an Armenian Population. Abraham Abraamyan1, B. Zanke3, P. Ramamoorthy2, K. W. Small1. 1Macula & Retina Institute, Glendale, CA; 2Advanced Diagnostics Laboratory, Denver, CO; 3Arctic Dx - Macula Risk, Bonita Springs, FL *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 386 Thursday – Posters – 6197 – 6214 6197 — C0082 Global Review and Metaanalysis of Diabetic Retinopathy Genetic Studies Highlight Gaps in the Pathogenesis between Various Populations. Shi Song Rong, P. Tam, C. Pang, L. Chen. Dept. Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China 6198 — C0083 Relating risk genotypes for diabetic retinopathy with color vision performance. Mirella Gualtieri1, D. M. Bonci2, V. D. Duarte Garcia2, S. Juel3, F. Damico5, M. Neitz4, D. F. Ventura1, 2. 1Experimental Psychology, University of Sao Paulo, Sao Paulo, Brazil; 2 Neuroscience & Behavio, University of Sao Paulo, Sao Paulo, Brazil; 3Minority Health and Health Disparities International Research Training Program, Menphis, TN; 4Ophthalmology, University of Washington, Seattle, WA; 5Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil *CR 6199 — C0084 MicroRNA-126 Regulates Heme Oxygenase-1-Mediated Alterations in Diabetic Retinopathy. Jiawen Fan, G. Xu, T. Jiang, Y. Qin, X. Wang. Ophthalmology Department, Eye and ENT Hospital of Fudan Univ, Shanghai, China 6200 — C0085 Identification of Risk Alleles in the Erythropoietin gene for Proliferative Diabetic Retinopathy in Type I and Type II Diabetics. Stephen Juel3, D. M. Bonci1, 2, M. Gualtieri1, 2, V. D. Duarte Garcia1, 2, M. Neitz4, D. F. Ventura1, 2. 1Psicologia Experimental, Universidade de São Paulo, São Paulo, Brazil; 2Núcleo de Neurociências e Comportamento, Universidade de São Paulo, São Paulo, Brazil; 3Minority Health International Research Training Program, Christian Brothers University, Memphis, TN; 4 Ophthalmology, University of Washington, Seattle, WA *CR 6201 — C0086 Expression Of VEGF-A Gene In Normal Retina And In PVR Retina. Claudio Azzolini1, I. S. Pagani2, D. Borroni1, 2, C. Pirrone2, D. Pigni2, M. Al Oum1, R. Vinciguerra1, S. Donati1, G. Porta2. 1Morphological and Surgical Sciences, University of Insubria - Circolo Hospital, Varese, Italy; 2Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy 6202 — C0087 Thrombophilic mutations and risk of retinal vein occlusion. Silvia R. Mendes, A. F. Campos, D. Beselga, A. Neves, J. Campos, D. Castanheira. Ophthalmology, Leiria, Leiria, Portugal 6205 — C0090 Transcriptional regulation of synaptotagmin 11 in retinal ganglion cells. Gillian C. Shaw1, 2, C. A. Berlinicke1, D. J. Zack1. 1 Ophthalmology, Johns Hopkins University, Baltimore, MD; 2Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD *CR 6206 — C0091 Systems Genetics of Intraocular Pressure—Mice to Humans: The Use of BXD Murine Reference Panel for Identifying Novel Genetic Modulators of Glaucoma and Bidirectional Translation. Monica M. Jablonski1, 2, S. Swaminathan1, H. Lu1, J. L. Wiggs3, R. W. Williams2, L. Lu2. 1Hamilton Eye Institute, Univ Tennessee Health Sci Ctr, Memphis, TN; 2 Anatomy & Neurobiology, The University of Tennessee Health Science Center, Memphis, TN; 3 Ophthalmology, Harvard Medical School MEEI, Boston, MA *CR 6207 — C0092 Genetic variation of superoxide dismutases in patients with primary open-angle glaucoma. Dragana Celojevic1, S. Nilsson2, A. Petersen1, G. Tasa3, E. Juronen3, M. Zetterberg1. 1 Institute of Neuroscience & Physiology, University of Gothenburg, Gothenburg, Sweden; 2Institute of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden; 3Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia 6208 — C0093 COCH Variants are not Associated with Primary-open Angle Glaucoma or Intraocular Pressure in Caucasians. Danyi Wang1, B. Fan1, Y. Liu2, M. A. Hauser2, R. Allingham3, J. L. Haines4, J. L. Wiggs1. 1 Ophthalmology, Harvard Med Sch, Massachusetts Eye & Ear Infirmary, Boston, MA; 2Ophthalmology & Medicine, Duke University Medical Center, Durham, NC; 3Ophthalmology, Duke University Medical Center, Durham, NC; 4Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN *CR 6209 — C0094 Family-based Genomewide Association Study in South Indian Consanguineous Pedigrees confirms association between ZNF469 and central corneal thickness. Baojian Fan1, N. Soumittra2, S. Sripriya2, D. S. Friedman3, V. Lingam4, J. L. Haines5, R. J. George4, J. L. Wiggs1. 1Dept of Ophthalmology, Harvard Med Sch Massachusetts Eye & Ear Infirmary, Boston, MA; 2Vision Research Foundation, Sankara Nethralaya, Chennai, India; 3Ophthalmology, Johns Hopkins Medical School Wilmer Eye Institute, Baltimore, MD; 4Medical Research Foundation, Sankara Nethralaya, Chennai, India; 5Center for Human Genetic Research, Vanderbilt University School of Medicine, Nashville, TN *CR 6210 — C0095 Fine mapping of the RXRACOL5A1 locus for central corneal thickness. Xiaoyi Gao1, Y. Liu2, W. Gauderman3, M. Torres1, T. Haritunians4, J. Z. Kuo4, K. Taylor4, J. I. Rotter4, R. Varma1. 1Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL; 2Department of Medicine, Duke University, Durham, NC; 3Department of Preventive Medicine, University of Southern California, Los Angeles, CA; 4Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA *CR 6211 — C0096 Validation of APLP2 as Potential Candidate Gene for Human Myopia Linked to Chromosome 11q24.3. Andrei V. Tkatchenko1, 2, P. Singh2, A. Kumar2, 1, T. V. Tkatchenko1. 1Anatomy & Cell Biology, Wayne State University, Detroit, MI; 2Ophthalmology, Wayne State University, Detroit, MI 6212 — C0097 UV-Independent p53 Mutations in Sebaceous Carcinoma of the Eyelid. Rehan M. Hussain1, J. L. Matthews1, S. R. Dubovy1, G. Wang2. 1 Ophthalmology, Bascom Palmer Eye Institute, Miami, FL; 2Human Genetics, John P. Hussman Institute for Human Genomics, Miami, FL 6213 — C0098 Genome-wide Analysis of Ocular Adnexal Lymphoproliferative Disorders Using High Resolution Single Nucleotide Polymorphism Array. Hiroki Takahashi1, Y. Usui1, R. Mitsuhashi1, N. Yamakawa1, A. Sato-Otsubo2, Y. Sato2, S. Ogawa2, A. Arai3, H. Goto1. 1Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan; 2Cancer Genomics Project, The University of Tokyo, Tokyo, Japan; 3Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan 6214 — C0099 Rb1 knockdown selectively induces cone precursor proliferation and tumor formation dependent on cone-specific signaling. Xiaoliang L. Xu1, P. K. Bradford4, H. P. Singh2, D. H. Abramson3, S. C. Jhanwar1, D. Cobrinik2. 1Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY; 2 Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY; 3Ocular Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY; 4Albert Einstein College of Medicine, New York, NY *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 387 Thursday Posters 10:30 am – 12:15 pm 6203 — C0088 Association study of IL23RIL12RB2 and IL10 gene polymorphisms with susceptibility to Vogt-Koyanagi-Harada disease in a Japanese population. Akira Meguro1, T. Kawagoe1, M. Nakahara1, 2, H. Fukasaku1, 2, S. Ohno3, N. Mizuki1. 1Department of Ophthalmology, Yokohama City Univ School of Med, Yokohama, Japan; 2Fukasaku Eye Clinic, Yokohama, Japan; 3 Ocular Inflammation and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan 6204 — C0089 Genetic Screening of TSPAN12, NDP and FZD4 Genes in Indian Patients with Retinopathy of Prematurity. Inderjeet Kaur1, S. Rathi1, G. R. Musada1, S. Jalali2, R. Kekunnaya3, P. Gaddam4, S. Chakrabarti1. 1Kallam Anji Reddy Molecular Genetics Lab, LV Prasad Eye Institute, Hyderabad, India; 2Smt.Kannuri Santhamma Centre for Vitreo Retinal Diseases, LV Prasad Eye Institute, Hyderabad, India; 3Jasti V Ramanamma Children’s Eye Care Centre, LV Prasad Eye Institute, Hyderabad, India; 4Fernandez Hospital, Hyderabad, India 6215 – 6232 – Thursday – Posters 6215 — C0100 Downregulation of MITF Leads to Uveal Melanoma Cell Apoptosis and Cell Cycle G1 Arrest. Lihua Wang, X. Chen, J. Wang, D. Yan. 1School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, China Exhibit Hall C0101-C0134 Thursday, May 09, 2013 10:30 AM-12:15 PM Glaucoma 542 Genetics II Moderators: Janey L. Wiggs and David A. Mackey 6216 — C0101 The association of single nucleotide polymorphisms in the connective tissue growth factor gene with pseudoexfoliation syndrome/glaucoma. Wool Suh1, C. Kee2. 1 Ophthalmology, Hallym University Sacred Heart Hosp, Anyang, Kyeonggi-do, Republic of Korea; 2 Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea 6217 — C0102 CYP1B1 mutations, a major contributor to juvenile-onset open angle glaucoma. Khaled K. Abu-Amero1, 3, J. Morales2, L. Ali Aljasim2, D. P. Edward2. 1Ophthalmology, College of Med, King Saud Univ, Riyadh, Saudi Arabia; 2King Khalied Eye Specilaist Hospital, Riyadh, Saudi Arabia; 3Ophthalmology, College of Medicine, Jacksonville, FL Thursday Posters 10:30 am – 12:15 pm 6218 — C0103 Last results of the Spanish Multicenter Genetic Glaucoma Group. Elena Milla1, 5, S. Duch2, M. Carballo3, M. Gamundi4. 1 Institut Comtal d’Oftalmologia and Hospital Clinic, Barcelona, Spain; 2Glaucoma, Institut Comtal d’Oftalmologia, Barcelona, Spain; 3Hospital de Terrassa, Barcelona, Spain; 4Hospital de Terrassa, Barcelona, Spain; 5Spanish Multicenter Genetic Glaucoma Group, 18 Spanish Eye Centers, Spain, Spain 6219 — C0104 Identification of S1 RNA Binding Domain-1 SRBD1 as a Major Gene Determining Glaucoma in Dogs. Nobuyuki Kanemaki1, K. T. Tchedre2, M. Imayasu2, A. Meguro3, N. Mizuki3. 1Veterinary Teaching Hospital, Azabu University, Sagamihara, Japan; 2Central R&D Laboratory, Menicon Co., Ltd., Kasugai, Japan; 3Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Japan *CR 6220 — C0105 MYOC Variants In POAG In Black South Africans. Susan E. Williams1, T. Wainstein2, T. R. Carmichael1, M. Ramsay2. 1 Ophthalmology, University of the Witwatersrand, Johannesburg, South Africa; 2Human Genetics, University of the Witwatersrand, Johannesburg, South Africa 6221 — C0106 Genetic Susceptibility Variations and Visual Field Progression in Chinese Patients with Primary Angle Closure Glaucoma. Xin Wei1, 2, C. Khor3, 4, J. S. de Leon2, E. N. Vithana2, 4, M. E. Nongpiur2, 4, S. Perera2, T. Aung2, 4. 1Duke-National University of Singapore Graduate Medical School, Singapore, Singapore; 2Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; 3Human Genetics, Genome Institute of Singapore, Singapore, Singapore; 4Department of Ophthalmology, National University Health System & National University of Singapore, Singapore, Singapore *CR 6222 — C0107 The Association Between Ocular Biometric Parameters and the Three Novel Primary Angle Closure Glaucoma (PACG) Susceptibility Loci. Monisha E. Nongpiur1, 2, C. Khor3, 4, L. Xu5, J. B. Jonas6, J. Wang5, T. Y. Wong1, 7, E. N. Vithana1, T. Aung1, 7. 1Glaucoma, Singapore Eye Research Inst, Singapore, Singapore; 2 DUKE-NUS Graduate Medical School, Singapore, Singapore; 3Genome Institute Of Singapore, Singapore, Singapore; 4Centre for Molecular Epidemiology, Singapore, Singapore; 5Beijing Institute of Ophthalmology, Beijing, China; 6 Ophthalmology, Medical Faculty MannheimHeidelberg, Mannheim, Germany; 7Ophthalmology, Yong Loo Lin School of Medicine, Singapore, Singapore *CR 6223 — C0108 Protein tyrosine phosphatase Meg2 deficient mice - A powerful model to study glaucoma disease? Jacqueline Reinhard1, S. Wiemann1, S. C. Joachim2, H. Schmid2, B. Denecke3, Y. Wang4, G. P. Downey5, 6, A. Faissner1. 1 Cell Morphology & Molecular Neurobiology, Ruhr-University Bochum, Bochum, Germany; 2 Experimental Eye Research Institute, RuhrUniversity Bochum, Bochum, Germany; 3 Interdisciplinary Center for Clinical Research, RWTH Aachen University, Aachen, Germany; 4 Department of Medicine, University of Toronto, Toronto, ON, Canada; 5Department of Medicine, National Jewish Health, Denver, CO; 6Departments of Medicine and Integrated Department of Immunology, University of Colorado, Aurora, CO 6224 — C0109 Association of Glutathione S Transferases Polymorphisms with Glaucoma: A Meta-analysis. Yibo Yu, K. Yao. Eye Center, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China 6225 — C0110 Predicting Gene Networks and Transcription Factors in TNFα Treatment of Trabecular Meshwork Cells. Dongseok Choi1, L. Hayashi2, K. Carr1, M. J. Kelley2, T. S. Acott2. 1 Biostatistics, Public Hlth & Preventive Med, Oregon Health & Science Univ, Portland, OR; 2 Casey Eye Institute, Oregon Health & Science Univ, Portland, OR 6226 — C0111 Mouse Genomic Loci Modulating Ganglion Cell Loss in Glaucoma. Eldon E. Geisert1, S. G. Hart1, X. Wang1, J. L. Wiggs2. 1Ophthalmology, Univ of Tennessee Health Sci Ctr, Memphis, TN; 2Ophthalmology, Harvard Medical School, Boston, MA 6227 — C0112 Association between primary open-angle glaucoma and genetic variants associated with normal tension glaucoma. Fumihiko Mabuchi1, Y. Sakurada1, K. Kashiwagi1, Z. Yamagata2, H. Iijima1. 1Ophthalmology, University of Yamanashi, Chuo, Japan; 2Health Sciences, University of Yamanashi, Chuo, Japan 6228 — C0113 Analysis of Ophthalmic Clinical Data Association for CDKN2B-AS1 Genotype in Normal Subjects. Yoko Ikeda1, K. Mori1, M. Ueno1, M. Nakano2, Y. Tokuda2, N. Omi2, R. Sato2, K. Yoshii3, K. Tashiro2, S. Kinoshita1. 1Ophthalmology, Kyoto Prefectural Univ of Med, Kamigyo-ku, Japan; 2Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoo, Japan; 3 Judo Therapy, Takarazuka University of Medical and Health Care, Takarazuka, Japan *CR 6229 — C0114 The Role of Protein-Coding Variants in South Africans with Exfoliation Glaucoma. Yutao Liu1, 2, X. Qin1, J. Gibson1, S. E. Williams3, R. M. Rautenbach4, T. R. Carmichael3, A. E. Ashley-Koch1, R. Allingham2, M. A. Hauser1, 2. 1 Medicine, Duke University Medical Center, Durham, NC; 2Ophthalmology, Duke University Medical Center, Durham, NC; 3Neurosciences, University of the Witwatersrand, Johannesburg, South Africa; 4Surgical Sciences, Stellenbosch University, Stellenbosch, South Africa *CR 6230 — C0115 Mouse Genomic Loci Modulating Corneal Thickness. XiangDi Wang1, S. G. Hart1, J. L. Wiggs2, E. E. Geisert1. 1 Ophthalmology, University of Tennessee Health Science Center, Memphis, TN; 2OphthalmologyHarvard Medical School, Mass Eye & Ear Infirmary, Boston, MA 6231 — C0116 Identification and Characterization of Genetic Factors Responsible for Cavitary Optic Disc Anomalies. Ralph J. Hazlewood1, B. Roos1, R. A. Honkanen2, L. M. Jampol3, W. L. Alward1, Y. H. Kwon1, E. M. Stone1, 4, J. H. Fingert1, 5. 1Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA; 2 Ophthalmology, State University of New York at Stony Brook, Stony Brook, NY; 3Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL; 4Howard Hughes Medical Institute, Iowa City, IA; 5Anatomy and Cell Biology, University of Iowa, Iowa City, IA *CR 6232 — C0117 Association Study of Multiple Gene Polymorphisms with the Risk of AdultOnset Primary Open-Angle Glaucoma in a Mexican Population. Jesus Cabral1, B. Buentello1, D. C. Guadarrama1, J. C. Zenteno1, 4, C. Elizondo2, A. Miranda3. 1Research Unit Genetics, Institute of Ophtalmology Conde De Valenciana, Mexico City, Mexico; 2Glaucoma Department, Institute of Ophtalmology Conde De Valenciana, Mexico City, Mexico; 3Department Of Genetics, National Institute of Rehabilitation, Mexico City, Mexico; 4 Department of Biochemistry, National Autonomous University of Mexico, Mexico City, Mexico The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 388 Thursday – Posters – 6233 – 6249 6233 — C0118 A genetic variant in TMCO1 is strongly associated with primary open angle, primary angle closure and pseudoexfolation glaucoma. Shazia Micheal1, 2, H. Ayub2, 1, M. I. Khan2, 3, B. Bakker1, F. E. Schoenmaker-Koller1, M. Ali4, F. Akhtar4, R. Qamar1, 5, A. I. Den Hollander1, 3. 1Ophthalmology, UMC St Radboud, Nijmegen, Netherlands; 2Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan; 3Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 4 Glaucoma, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan; 5Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan 6239 — C0124 Rare Genetic Variants in African Americans with Primary Open Angle Glaucoma. Allison E. Ashley-Koch1, X. Qin1, J. Gibson1, Y. Liu1, 2, J. L. Wiggs3, J. E. Richards4, S. E. Moroi4, C. A. Girkin5, R. Allingham2, M. A. Hauser1, 2. 1Center for Human Genetics, Duke University Medical Center, Durham, NC; 2 Department of Opthalmology, Duke University Medical Center, Durham, NC; 3Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA; 4Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, MI; 5Department of Ophalmology, University of Alabama at Birmingham School of Medicine, Birmingham, AL *CR 6234 — C0119 The association between CAV1/2 region loci and their relation with primary open angle glaucoma. Stephanie Loomis1, 2, L. R. Pasquale1, 2, J. H. Kang2, M. A. Hauser4, 5, B. Yaspan3, J. L. Haines3, J. L. Wiggs1. 1Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA; 2Department of Medicine, Channing Division of Network Medicine, Boston, MA; 3Center for Human Genetics Research, Vanderbilt University, Nashville, TN; 4Department of Ophthalmology, Duke University, Durham, NC; 5 Department of Medicine, Duke University Medical Center, Durham, NC *CR 6240 — C0125 Secondary Glaucoma in transthyretin (TTR)-related Familial Amyloid Polyneuropathy. Antoine Rousseau1, E. Barreau1, G. Kaswin1, M. Mgarrech1, M. Théaudin2, C. Cauquil2, D. Adams2, M. Labetoulle1. 1 Ophthalmology, Bicetre Hospital, South Paris University, Le Kremlin Bicêtre, France; 2Neurology, Bicetre Hospital, South Paris University, Le Kremlin Bicêtre, France *CR 6235 — C0120 Next Generation Sequencing Identifies Novel Variants of Mitochondrial DNA in Normal-Tension Glaucoma Patients. Dong Myung Kim1, J. Jeoung1, M. Seong2, S. Park2. 1Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea; 2Laboratory Medicine, Seoul National University Hospital, Seoul, Republic of Korea 6236 — C0121 Revisit the association of CAV1/ CAV2 with primary open-angle glaucoma. Li Jia Chen, P. Tam, C. Pang. Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China 6238 — C0123 POAG blood and hyaluronic acid challenged monocytes upregulate CD44s and isoforms: A new biomarker? Paulius Kuprys1, A. Grybauskas1, K. Skuran1, P. A. Knepper1, 2. 1 Ophthalmology and Visual Sciences, Univerisity of Illinois at Chicago, Chicago, IL; 2Ophthalmology, Northwestern University Medical School, Chicago, IL 6242 — C0127 Expanded Phenotype of Axenfeld Spectrum: Congenital Hypothyroidism and Glaucoma. Elena Bitrian1, E. W. McPherson2, A. L. Grajewski1, 3. 1Ophthalmology, University of Minnesota, Minneapolis, MN; 2Genetics, Marshfield Clinic, Marsfield, WI; 3Pediatric Glaucoma, Bascom Palmer Eye Institute, Miami, FL *CR 6243 — C0128 Candidate regulatory lysyl oxidase-like 1 (LOXL1) variants in pseudoexfoliation syndrome/glaucoma are associated with differential LOXL1 expression. Matthias Zenkel1, F. Pasutto2, J. Onderka1, A. W. Krysta1, A. Moessner1, F. E. Kruse1, U. SchlotzerSchrehardt1. 1Department of Ophthalmology, University Erlangen Nuernberg, Erlangen, Germany; 2Department of Human Genetics, University Erlangen Nuernberg, Erlangen, Germany 6246 — C0131 Exome chip analysis identifies rare variants associated with primary open angle glaucoma. William K. Scott1, M. D. Courtenay1, D. L. Budenz3, R. K. Lee2, J. L. Haines4, M. A. PericakVance1. 1Hussman Institute of Human Genomics, University of Miami, Miami, FL; 2Bascom Palmer Eye Institute, University of Miami, Miami, FL; 3 Ophthalmology, University of North Carolina, Chapel Hill, NC; 4Center for Human Genetics Research, Vanderbilt University, Nashville, TN *CR 6247 — C0132 Association between IL1A, IL1B and TNFA polymorphisms and glaucoma in a Brazilian population. Mariana Oliveira1, 2, J. C. Vasconcellos2, 1, V. P. Costa2, G. Ananina1, M. B. Melo1. 1Center of Molecular Biology and Genetic Engineering, University of Campinas, UNICAMP, Campinas, Brazil; 2Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas, UNICAMP, Campinas, Brazil 6248 — C0133 Functional Analysis of LOXL1 Missense Variants in the Pathophysiology of Pseudoexfoliation Syndrome/Glaucoma. Ursula Schlotzer-Schrehardt1, T. Sasaki2, M. Zenkel1, F. E. Kruse1, A. W. Krysta1. 1Department of Ophthalmology, University of Erlangen-Nürnberg, Erlangen, Germany; 2Department of Experimental Medicine I, University of Erlangen-Nürnberg, Erlangen, Germany 6249 — C0134 Mapping of two modifier loci for glaucoma severity on chromosome 20. Vincent Raymond1, 2, P. Belleau1, S. Dubois1, R. Arseneault1. Shink1, 2, J. Anctil3, G. Côté3, M. A. Walter4, M. Amyot5. 1Neurosciences, CHU de Québec/CHUL (Université Laval Hospital) Research Centre, Québec City, QC, Canada; 2Molecular Medicine, Université Laval, Québec City, QC, Canada; 3 Ophthalmology, Université Laval, Québec City, QC, Canada; 4Medical Genetics, University of Alberta, Edmonton, AB, Canada; 5Ophthalmology, Université de Montréal, Montréal, QC, Canada 6244 — C0129 Spatial Distribution of Mutations in ASB10 and MYOC. Colin Marrs1, S. J. Garnai1, N. Lopes1, D. M. Reed1, K. E. Branham1, M. I. Othman1, S. E. Moroi1, J. R. Heckenlively1, H. S. Pawar1, J. E. Richards1, 2. 1Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI; 2Epidemiology, University of Michigan, Ann Arbor, MI *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 389 Thursday Posters 10:30 am – 12:15 pm 6237 — C0122 Clinical Profile Of A Large Family With Primary Open Angle Glaucoma (POAG) In South Indian Population. Mohideen A. Kader1, R. Ramakrishnan1, S. Krishnadas2, P. Namburi3, P. Sundaresan3, A. L. Robin4, P. Y. Ramulu5, J. H. Fingert6. 1Glaucoma, Aravind Eye Hospital, Tirunelveli, India; 2Glaucoma, Aravind Eye Hospital, Madurai, India; 3Genetics, Aravind Medical Research Foundation, Madurai, India; 4 John Hopkins University, Baltimore, MD; 5Wilmer Eye Institute, Baltimore, MD; 6Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA *CR 6241 — C0126 Identification and expression of candidate genes in pseudoexfoliation. Kamesh Dhamodaran1, R. S. Shetty1, M. Subramani1, V. Patil2, B. K. Shetty2, D. Das1. 1Stem Cell Research Laboratory, Narayana Nethralaya Post Graduate Inst of Ophthalmology, Bangalore, India; 2Cataract and Refractive Lens Surgery, Narayana Nethralaya Post Graduate Inst of Ophthalmology, Bangalore, India 6245 — C0130 Conserved anatomic features in sibling pairs concordant for angle closure. Palaniswamy Krishnamurthy1, R. Venkatesh1, P. Y. Ramulu2, S. Kavitha1, D. S. Friedman2, H. Quigley2, R. Wojciechowski3, F. Seager2. 1Aravind Eye Hospital, Pondicherry, India; 2Wilmer Eye Institute, Baltimore, MD; 3Johns Hopkins Bloomberg School of Public Health, Baltimore, MD *CR 6250 – 6268 – Thursday – Posters Exhibit Hall D0058-D0070 Thursday, May 09, 2013 10:30 AM-12:15 PM Retina 543 Proliferative Vitreoretinopathy Moderators: Francesco Boscia and Dov Weinberger 6250 — D0058 Comparison of Gene Expression Profile of Epiretinal Membranes obtained from Eyes with Proliferative Vitreoretinopathy to that of Secondary Epiretinal Membranes. Shigeo Yoshida, R. Asato, T. Nakama, K. Ishikawa, S. Nakao, Y. Sassa, H. Enaida, Y. Oshima, T. Ishibashi. Ophthalmology, Kyushu University, Fukuoka-shi, Japan 6251 — D0059 miR-135b Regulates TGFβ1-Mediates Retinal Pigment EpithelialMesenchymal Transition. Fang Wang, H. Li, M. Li. Tenth People’s Hospital of Tongji University, Shanghai, China 6252 — D0060 β-catenin signaling in RPE in experimental PVR. Kazuhiko Umazume1, 2, L. Liu1, K. McDonald1, H. Goto2, H. J. Kaplan1, S. Tamiya1. 1 Ophthalmology & Visual Sciences, University of Louisville, Louisville, KY; 2Ophthalmology, Tokyo Medical University, Tokyo, Japan 6253 — D0061 Periostin Promotes the Generation of Fibrous Membranes in Proliferative Vitreoretinopathy. Keijiro Ishikawa1, S. Yoshida1, S. Nakao1, T. Nakama1, T. Kita1, Y. Sassa1, 2, H. Enaida1, Y. Oshima1, T. Kono2, T. Ishibashi1. 1Ophthalmology, Kyushu University, Fukuoka, Japan; 2Ophthalmology, Fukuoka University Chikushi Hospital, Fukuoka, Japan Thursday Posters 10:30 am – 12:15 pm 6254 — D0062 Suppression of Retinal Pigment Epithelial Cell Proliferation, Migration and Epithelial-mesenchymal transition by Proteasome Inhibition, a Potential Defense against Proliferative Vitreoretinopathy. Chuan Chen1, Y. Zhu1, Y. Lin1, Z. Liu1, M. Wu1, D. W. Li2, B. Cheng1. 1Zhongshan Ophthalmic Center, Sun Yatsen University, Guangzhou, China; 2Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 6255 — D0063 Factor Xa and thrombin induce epithelial to mesenchymal transition by retinal pigment epithelial cells via PDGF-signaling. Jeroen Bastiaans1, J. C. van Meurs2, 3, C. van Holten - Neelen1, P. M. Van Hagen1, 4, N. Nagtzaam1, H. Hooijkaas1, W. A. Dik1. 1Immunology, Erasmus MC, Rotterdam, Netherlands; 2The Rotterdam Eye Hospital, Rotterdam, Netherlands; 3Ophthalmology, Erasmus MC, Rotterdam, Netherlands; 4Internal Medicine, Erasmus MC, Rotterdam, Netherlands 6256 — D0064 Aquaporin-1 Expression in Membranes from Proliferative Vitreoretinopathy and in Epiretinal Membranes. Laure E. Caspers1, E. Motulsky1, 2, D. Salik1, 2, X. Janssens1, 3, B. Pion1, 3, N. Bolaky2, F. Gregoire2, J. Perret2, F. Willermain1, 4, C. Delporte2. 1Ophthalmology, CHU Saint-Pierre Hospital - ULB, Brussels, Belgium; 2Laboratory of Pathophysiological and Nutritional Biochemistry, Université Libre de Bruxelles (ULB), Brussels, Belgium; 3Ophthalmlogy, Saint-Anne SaintRémi Hospital, Brussels, Belgium; 4I.R.I.B.H.M, Université Libre de Bruxelles (ULB), Brussels, Belgium 6262 — D0070 Novel Anti-CTGF RNAi Therapy for Treatment of Proliferative Vitreoretinopathy (PVR) and other Ocular Disorders. Geoffrey P. Lewis2, M. Byrne1, S. K. Fisher2, J. Cardia1, L. Pandarinathan1, K. Bulock1, L. Libertine1, P. A. Pavco1. 1RXi Pharmaceuticals, Westborough, MA; 2Neuroscience Research Institute, Univ of California Santa Barbara, Santa Barbara, CA *CR 6257 — D0065 Distribution of MDM2 T309G polymorphism in European patients with Proliferative Vitreoretinopathy. Retina 4 project. Salvador Pastor1, 2, I. Rodriguez-Hernandez2, J. Rojas Spano1, R. Gonzalez-Sarmiento2, J. Pastor1. 1 Ophthalmology, IOBA-University of Valladolid, Valladolid, Spain; 2Medicine, Molecular Medicine Unit, IBMCC and IBSAL, Salamanca, Spain Retina 6258 — D0066 Epithelial cells promote fibroblast-mediated contraction of collagen gels by secreting bFGF. Maryada Sharma, H. Lei, S. Pennock, A. Kazlauskas. The Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 6259 — D0067 Analysis of vitreous hyaluronan status in viteroretinal diseases. Koichi Nishitsuka1, M. Narumi1, Y. Kashiwagi2, T. Shibata3, J. Gong3, H. Furukawa3, H. Yamashita1. 1Ophthalmology/ Vis Sci, Yamagata University Sch of Med, Yamagata-shi, Japan; 2Yonezawa Women’s Junior College, Yonezawa, Japan; 3Mechanical Systems Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa, Japan *CR 6260 — D0068 Effect of SAHA on Fibrotic Change in Primate Retinal Pigment Epithelium Cells and Vitreous Cells. Hiroki Hatanaka1, N. Okumura2, 1, N. Koizumi2, E. Mizuhara2, H. Hirano2, J. Hamuro1, S. Kinoshita1. 1Ophthalmology, Kyoto Prefectural Univ of Med, Kyoto, Japan; 2Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, kyotanabe, Japan *CR 6261 — D0069 Immunospecific targeting of fibronectin towards an anti-fibrotic therapy, with special emphasis on proliferative vitreoretinopathy (PVR). Manni LuthraGuptasarma1, M. Sharma1, 3, S. Sharma1, A. Tiwari1, V. Gupta2, A. Gupta2. 1Immunopathology, PGIMER Chandigarh, Chandigarh, India; 2Ophthalmology, PGIMER Chandigarh, Chandigarh, India; 3The Schepens Eye Research Institute; Department of Ophthalmology and Visual Sciences, Harvard Medical School, Boston, MA *CR Exhibit Hall D0079-D0129 Thursday, May 09, 2013 10:30 AM-12:15 PM 544 AMD IV, RE Moderator: Amani A. Fawzi 6263 — D0079 The Rod Intercept: An Improved Method for Estimating Rod-Mediated Dark Adaption Speed. John G. Edwards1, G. R. Jackson2. 1MacuLogix, Inc, Atlanta, GA; 2Penn State College of Medicine, Hershey, PA *CR 6264 — D0080 Specular Photomicrographic Assessment of the Effect of Anti-VEGF intravitreal injections on corneal thickness and endothelial cell density (CD) and morphology. Fayssal El-Jabali, G. Papastergiou, M. D. Bennett, K. E. Waite. Ophthalmology - Retina, Retina Institute of Hawaii, Honolulu, HI 6265 — D0081 Retinal and choroidal thickness changes over time in patients with neovascular age-related macular degeneration treated with anti-VEGF. Thais S. Mendes, M. Menghini, A. L. Levison, S. Rofagha, R. B. Bhisitkul. Ophthalmology, UCSF, San Francisco, CA *CR 6266 — D0082 Is foveal RPE autofluorescence a predictor of visual outcome in wet Age Related Macular Degeneration patients treated with Ranibizumab? Maria Dimitry, N. Jain, L. North, M. N. Chandran, G. Menon. Frimley Park Hospital, Frimley, United Kingdom *CR 6267 — D0083 Intravitreal anti-VEGF therapy for vascularized serous pigment epithelial detachment in age-related macular degeneration. Lucia Finocchio, D. Bacherini, F. Giansanti, G. Giacomelli, C. Mazzini, L. Vannozzi, I. Biagini, G. Virgili, U. Menchini. Department of Specialistic Surgical Sciences, Eye Clinic, University of Florence, Florence, Italy 6268 — D0084 Outer Retinal Tubulations in the Comparison of AMD Treatments Trials (CATT). Joo Yong Lee1, 2, F. A. Folgar1, C. A. Toth1, G. J. Jaffe1. 1Duke Eye Center, Durham, NC; 2 Ophthalmology, Asan Medical Center, University of Ulsan, Seoul, Republic of Korea *CR, f The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 390 Thursday – Posters – 6269 – 6287 6269 — D0085 Retinal Pigment Epithelium Atrophy in Patients Receiving Intravitreal Anti-Vascular Endothelial Growth Factor Therapy for Neovascular Age-Related Macular Degeneration. Luna Xu1, 2, S. Mrejen1, 4, R. GallegoPinazo1, 5, J. J. Jung1, 3, M. Marsiglia1, 4, S. Boddu3, K. Freund1, 3. 1Vitreous Retina Macula Consultants of New York, New York, NY; 2Department of Medicine, St. Vincent’s Medical Center, Bridgeport, CT; 3Department of Ophthalmology, New York University School of Medicine, New York, NY; 4LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, NY; 5Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, Spain *CR 6270 — D0086 Aflibercept (Eylea) Effect on Macula Thickness and Visual Acuity in Exudative AMD Patients Recalcitrant to Ranibizumab and Bevacizumab. Vincent Hau, M. Samuel, M. Davis, K. Lin, T. Chang. Retina Institute of California, Riverside, CA *CR 6271 — D0087 Comparison of Treatment Schedules in an Integrated Analysis of the VIEW Studies. Papp András1, B. Sommerauer2, O. Sowade2. 1 Department of Ophthalmology, Semmelweis University Budapest, Budapest, Hungary; 2Bayer Healthcare, Berlin, Germany *CR, f 6272 — D0088 Early fluid clearance following intravitreal ranibizumab injection for neovascular age-related macular degeneration. Kathy Jao1, D. S. Chauhan2. 1Department of Medicine, University of Melbourne, Melbourne, VIC, Australia; 2Vision Retinal Institute Eastern, Melbourne, VIC, Australia *CR 6273 — D0089 ForeseeHome in AREDS2Home Monitoring of AMD patients: Study Design, Enrollment, Baseline Characteristics and Initial Device Usage. Michael J. Elman1, 2, S. B. Bressler2, T. E. Clemons3, E. Y. Chew4. 1Elman Retina Group PA, Baltimore, MD; 2Johns Hopkins University School of Medicine, Baltimore, MD; 3 Emmes Corporation, Bethesda, MD; 4National Eye Institute, Bethesda, MD *CR 6276 — D0092 Association Between Required Length of Intravitreal Anti-VEGF Therapy in Exudative Age-Related Macular Degeneration and Initial Central Macular Thickness as Measured by Optical Coherence Tomography. Blake Isernhagen, S. R. Fransen. Dean McGee Eye Institute, Oklahoma City, OK 6277 — D0093 Quantification of the area of retinal pigment epithelium tears in age-related macular degeneration. Christoph R. Clemens, F. Alten, C. Baumgart, P. Heiduschka, N. Eter. Ophthalmology, University Eye Hospital, Muenster, Germany *CR 6278 — D0094 Correlation Between Fluid Status at Week 12 and Week 52 Following Intravitreal Aflibercept Injections in the VIEW Study of wAMD Patients. Jeffrey L. Marx1, D. M. Moshfeghi2, S. M. Hariprasad3, J. S. Heier4. 1 Department of Ophthalmology, Lahey Clinic, Peabody, MA; 2Department of Ophthalmology, Stanford University, Palo Alto, CA; 3Department of Ophthalmology, University of Chicago, Chicago, IL; 4Ophthalmic Consultants of Boston and Tufts University School of Medicine, Boston, MA *CR, f 6279 — D0095 Wide Field Fluorescein Angiography in Silicone Oil Filled Eyes. Goran Bencic1, M. Zoric-Geber1, Z. Vatavuk1, T. R. Friberg2. 1University Department of Ophthalmology, University Clinical Hospital “Sestre milosrdnice”, Zagreb, Croatia; 2Retina Service, UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA *CR 6280 — D0096 Impact of reticular pseudodrusen on macular function. Giuseppe Querques, N. Massamba, M. Srour, E. Boulanger-Scemama, L. Querques, E. H. Souied. Ophthalmology, University Paris Est Creteil, Cretil, France *CR 6281 — D0097 Photoreceptor Abnormalities in Intermediate Age-Related Macular Degeneration. Sam Sadigh1, A. V. Cideciyan1, A. M. Sumaroka1, W. Huang1, X. Luo1, M. Swider1, J. D. Steinberg1, D. Stambolian2, S. G. Jacobson1. 1 Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA; 2Ophthalmology and Genetics, University of Pennsylvania, Philadelphia, PA 6282 — D0098 Individual Retinal Pigment Epithelium Cells can be Imaged In Vivo in Age Related Macular Degeneration. Ethan A. Rossi1, D. R. Williams1, 2, A. Dubra4, 5, L. R. Latchney3, M. A. Folwell1, W. Fischer3, H. Song1, M. M. Chung3, 1. 1Center for Visual Science, University of Rochester, Rochester, NY; 2The Institute of Optics, University of Rochester, Rochester, NY; 3Flaum Eye Institute, University of Rochester, Rochester, NY; 4 Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 5Biophysics, Medical College of Wisconsin, Milwaukee, WI *CR 6283 — D0099 Photoreceptor Structure in Patients with Increased Genetic Risk for AgeRelated Macular Degeneration. Megan E. Land3, R. F. Cooper4, E. Berg5, T. Kitchner6, J. Young1, K. E. Stepien1, T. B. Connor1, D. Page7, M. Brilliant6, J. Carroll1, 2. 1Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 2Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI; 3Medical College of Wisconsin, Milwaukee, WI; 4Biomedical Engineering, Marquette University, Milwaukee, WI; 5Computer Sciences, University of Wisconsin Madison, Madison, WI; 6Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI; 7Biostatistics & Medical Informatics, University of Wisconsin Madison, Madison, WI *CR 6284 — D0100 Cellular Features of Retinal Pigment Epithelial Atrophy after Regression of Choroidal Neovascularization. Mina M. Chung1, 2, H. Song2, 1, L. R. Latchney1, M. A. Folwell2, W. Fischer1, E. A. Rossi2. 1Flaum Eye Institute, University of Rochester, Rochester, NY; 2Center for Visual Science, University of Rochester, Rochester, NY *CR 6285 — D0101 The role of Optical Coherence Tomography (OCT) for the diagnosis, monitoring, and guiding of treatment for neovascular Age-related Macular Degeneration (nAMD): an evidence synthesis study. Noemi Lois1, A. Azuara-Blanco2, G. Mowatt2, M. M. Castillo de Chacon2, A. Elders2, C. Ramsay2, J. Burr3. 1Ophthalmology Department, Grampian Univ Hosp/NHS Trust, Aberdeen, United Kingdom; 2 Health Services Research Unit, University of Aberdeen, Aberdeen, Scotland, United Kingdom; 3 School of Medicine, University of St Andrews, St Andrews, United Kingdom 6286 — D0102 Towards Automated Assessment of AREDS Severity Scale and Simple Scale Using RTVue® Spectral Domain Optical Coherence Tomography Tools. Qienyuan Zhou1, Y. Wolfson2, V. Chaikitmongkol2, 3, N. M. Bressler2. 1Optovue, Inc., Fremont, CA; 2Retina Division, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD; 3Department of Ophthalmology, Chiang Mai University, Chiang Mai, Thailand *CR 6287 — D0103 Detachment of CNV from Bruch membrane due to contraction of fibrovascular membrane in AMD. Ryo Mukai, T. Sato, S. Kishi, N. Hanyuda. Ophthalmology, Gunma Graduate school of medicine, Gunma, Japan *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 391 Thursday Posters 10:30 am – 12:15 pm 6274 — D0090 Predictive Factors for Visual Acuity “Gain and Maintain” after Ranibizumab Treatment for Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy. Yuji Oshima, S. Shiose, M. Yasuda, K. Kano, A. Yoshida, K. Ishikawa, S. Notomi, S. Yoshida, T. Ishibashi. Ophthalmology, Kyushu Univ, Faculty of Med, Fukuoka, Japan *CR 6275 — D0091 Morphologic effects of antiVEGF therapy on retinal pigment epithelium (RPE) and choroidal vasculature (CV) in neovascular age-related macular degeneration (AMD). Ursula Schmidt-Erfurth1, C. Schuetze1, S. M. Waldstein1, B. S. Gerendas1, C. Simader1, L. Zhang3, M. D. Abramoff3, M. Sonka3, B. Baumann2, C. K. Hitzenberger2. 1Department of Ophthalmology, Medical University of Vienna, Vienna, Austria; 2Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria; 3Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, IA *CR 6288 – 6310 – Thursday – Posters 6288 — D0104 Optical Coherence Tomography and fluorescein angiography in the diagnosis of choroidal neovascularization of age-related macular degeneration. Ramin Tadayoni1, V. Gualino1, 5, S. Y. Cohen1, 2, G. Quentel2, B. Haouchine1, 3, A. Erginay1, P. Massin1, E. Vicaut4, A. Gaudric1. 1Ophthalmology, Lariboisiere University Hospital, Paris, France; 2Centre d’imagerie et de laser, Paris, France; 3Centre d’exploration de la vision, Rueil Malmaison, France; 4Clinical Research Unit, Lariboisiere University Hospital, Paris, France; 5Clinique du docteur Cave, Montauban, France *CR, f 6289 — D0105 Optical Coherence Tomographic Findings in Wet Age-Related Macular Degeneration Refractory to Bevacizumab after Intravitreal Aflibercept Therapy. Carmel Moazez1, 2, K. Attaran-Rezaei2, C. H. Sell2, 1, S. Bryan2, S. De Souza2, A. J. Gordon2, H. M. Kwong2, R. Reddy2, B. Shirkey2, M. C. Ziemianski2. 1University of Arizona College of Medicine-Phoenix, Phoenix, AZ; 2Associated Retina Consultants, Phoenix, AZ 6290 — D0106 Inner Retinal Layers Damage in Age-related Macular Degeneration. Ulfah Rimayanti, K. Yamane, M. Latief, H. Mochizuki, J. Hirata, Y. Kiuchi. Ophthalmology and Visual Science Department, Hiroshima University, Hiroshima, Japan 6291 — D0107 Comparison of spectral domain and time domain OCT for qualitative and quantitative fluid assessments in the Comparison of AMD Treatments Trials (CATT). Francisco A. Folgar1, C. A. Toth1, G. Ying2, M. G. Maguire2, G. J. Jaffe1. 1Ophthalmology, Duke University, Durham, NC; 2Ophthalmology, University of Pennsylvania, Philadelphia, PA *CR, f 6292 — D0108 Optical coherence tomographic correlates of angiographic subtypes of occult choroidal neovascularization. Amirhossein Hariri1, F. M. Heussen1, 2, M. Nittala1, S. Sadda1. 1 Doheny Eye Inst/Univ of Sthrn California, Los Angeles, CA; 2Charite - University Medicine Berlin, Berlin, Germany *CR Thursday Posters 10:30 am – 12:15 pm 6293 — D0109 One-year macular volume change of the neurosensory retina in intermediate AMD by SDOCT semi-automated segmentation. Eric L. Yuan1, F. A. Folgar1, S. J. Chiu2, S. Farsiu1, 2, C. A. Toth1, 2. 1Ophthalmology, Duke University, Durham, NC; 2Biomedical Engineering, Duke University, Durham, NC *CR 6294 — D0110 Vitelliform-Like Lesions Associated with Type 1 Choroidal Neovascularization. Sabah Shah1, 2, V. P. Shah2, 1 , K. Freund2, 1. 1Ophthalmology, New York University, New York, NY; 2Vitreous-RetinaMacula Consultants of New York, New York, NY *CR 6295 — D0111 The Role of Anti-VEGF Therapy in the Development and Progression of Geographic Atrophy in Patients with Wet Age-Related Macular Degeneration. Justin Shaw, P. H. Scharper. Ophthalmology, Sinai Hospital of Baltimore, Krieger Eye Institute, Baltimore, MD 6296 — D0112 OCT Minimum Intensity as a Predictor of Geographic Atrophy Enlargement. Paul F. Stetson1, Z. Yehoshua2, C. A. Garcia Filho2, G. Gregori2, P. J. Rosenfeld2. 1Carl Zeiss Meditec, Dublin, CA; 2Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL *CR, f 6297 — D0113 Progression of Geographic Atrophy Predicted by SD-OCT En Face Imaging of the Outer Retina. Renata Portella Nunes1, 2, Z. Yehoshua1, A. A. Moshfeghi1, G. Gregori1, P. F. Stetson3, W. J. Feuer1, P. J. Rosenfeld1. 1 Ophthalmology, Bascom Palmer Eye Institute, Miami, FL; 2Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil; 3Research and Development, Carl Zeiss Meditec, Dublin, CA *CR, f 6298 — D0114 Assessment of linearity of growth in time in geographic atrophy secondary to age-related macular degeneration. Jordi M. Mones1, 2, M. Biarnes1, 2. 1Centro Medico Teknon, Institut de la Macula de la Retina, Barcelona, Spain; 2 Barcelona Macula Foundation, Barcelona, Spain *CR, f 6299 — D0115 Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in eyes with Geographic Atrophy secondary to Age-related Macular Degeneration. Athanasios Bezatis1, E. Becker1, C. K. Brinkmann1, S. SchmitzValckenberg1, R. Fimmers2, M. Fleckenstein1, F. G. Holz1. 1Ophthalmology, University of Bonn, Bonn, Germany; 2Institute for Medical Biometry, Informatics and Epidemiology, Bonn, Germany *CR 6300 — D0116 A lack of delayed intraocular pressure elevation after intravitreal injections of ranibizumab for age-related macular degeneration. Yusuke Ichiyama, T. Sawada, M. Kakinoki, O. Sawada, Y. Saishin, H. Kawamura, M. Ohji. ophthalmology, Shiga University of Medical Science, Otsu, Japan *CR 6301 — D0117 Longterm effect of multiple intravitreal anti VEGF injection on intraocular pressure. Yoon Jeon Kim, K. Sung, Y. Chung, K. Lee, S. Joe, J. Lee, J. Kim, Y. Yoon. Asan Medical Center, Seoul, Republic of Korea *CR 6302 — D0118 Effect of an Intravitreal AntiVEGF Injection on the Dynamics of the Anterior Segment. Jonathan Naysan1, T. Suthar1, R. M. Lieberman2, J. Jonisch1, 3. 1Ophthalmology, North Shore - Long Island Jewish, Great Neck, NY; 2 Ophthalmology, Mount Sinai University Medical Center, New York, NY; 3Ophthalmology, Long Island Vitreoretinal Consultants, Great Neck, NY 6303 — D0119 Intraocular pressure monitoring in patients with ranibizumab development. Anna Plyukhova, M. A. Karpilova, A. V. Kuznetsov, I. V. Andreeva, O. A. Gabina, M. V. Budzinskaya, V. P. Erichev, S. E. Avetisov. State Research Institute of Eye Diseases of Russian Academy of Medical Sciences, Moscow, Russian Federation *CR 6304 — D0120 Persistent ocular hypertension following intravitreal injections. Emilie Agard, H. El Chehab, I. Douma, G. Ract-Madoux, C. Dussart, C. Dot. Ophthalmology, Hopital Desgenettes, Bron, France f 6305 — D0121 Evaluating safety and efficacy of intravitreal Ranibizumab injection in AMD patients and recommendations to improve the standards of AMD service. Yasir Khan, M. Kim, S. Kang, S. George. Medical Retina, Western Eye Hospital, Imperial College London, London, United Kingdom *CR 6306 — D0122 The UNVEIL (Utilizing raNibizumab intraVitrEal Injection in reaL-world setting) study interim results: Effectiveness and safety of ranibizumab in the treatment of neovascular age-related macular degeneration under real-life conditions in patients from Africa, Asia and the Middle East. Mohamed Mahgoub1, N. K. Yadav2, V. Mester3, K. E. Legodi4, H. Kim5, E. Wu6, S. Hristoskova6, S. DiTommaso6. 1Ophthalmology, Ain Shams University, Cairo, Egypt; 2Narayana Nethralaya, Bangalore, India; 3Ophthalmology, Samaya Specialized Center, Abu Dhabi, Saudi Arabia; 4 Ophthalmology, Medforum Medi-clinic, Pretoria, South Africa; 5Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University, Seoul, Republic of Korea; 6Novartis Pharma AG, Basel, Switzerland *CR 6307 — D0123 Role of biomechanical properties of fibrous coat of the eye in intraocular pressure changes in patients after intravitreal ranibizumab injections. Pilot study. Ekaterina Chikun, M. A. Karpilova, A. V. Kuznetsov, I. V. Andreeva, O. A. Gabina, A. Plyukhova, M. V. Budzinskaya, V. P. Erichev, S. E. Avetisov. State Research Institute of Eye Disease of Russian Academy of Medical Sciences, Moscow, Russian Federation *CR 6308 — D0124 Efficacy and Safety of 0.5 mg or 2.0 mg Ranibizumab in Patients with Wet Age-Related Macular Degeneration: HARBOR 2-Year Results. David W. Faber1, Z. Li2, P. Lai2. 1 Rocky Mountain Retina Consultants, Salt Lake City, UT; 2Genentech, South San Francisco, CA *CR, f 6309 — D0125 Association of Systemic Anticoagulation and Rate of Intraocular Hemorrhage Following Intravitreal Anti-VEGF Therapy for Age-related Macular Degeneration. Joanna Olson1, I. U. Scott1, 2, D. Kerchner1, A. Kunselman2. 1Penn State Hershey Eye Center, Hershey, PA; 2Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA *CR 6310 — D0126 Microbial spectrum of endophthalmitis following intravitreal injection versus pars plana vitrectomy. Michael Dollin, P. P. Storey, J. D. Pitcher, J. Vander, J. Hsu, S. J. Garg. Wills Eye Institute, Philadelphia, PA *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 392 Thursday – Posters – 6311 – 6333 6311 — D0127 Index of Non Circularity as a Predictor for Progression in Eyes with Geographic Atrophy (GA). Ronald P. Danis, A. Domalpally, E. Corkery, R. A. Shaw, A. R. Narkar, J. White. Ophthalmology & Visual Sciences, Univ of Wisconsin-Madison, Madison, WI *CR 6312 — D0128 Predictors for the progression of geographic atrophy in patient with age-related macular degeneration : fundus autofluorescence study with modified fundus camera. Yong Jin Jeong1, I. Hong1, J. Chung1, H. Kim1, S. Park1, 2. 1 Ophthalmology, Kangdong Sacred Heart Hospital, Seoul, Republic of Korea; 2Ophthalmology, Columbia University Medical Center, New York, NY 6313 — D0129 Directional kinetics of geographic atrophy progression in age-related macular degeneration with foveal sparing. Monika Fleckenstein1, A. Böker1, C. K. Brinkmann1, S. Schmitz-Valckenberg1, R. Fimmers2, F. G. Holz1. 1 Department of Ophthalmology, University of Bonn, Bonn, Germany; 2Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany *CR, f Exhibit Hall D0185-D0236 Thursday, May 09, 2013 10:30 AM-12:15 PM Physiology/Pharmacology / Biochemistry/ Molecular Biology / Visual Neuroscience 545 Retina: Physiology and Pharmacology Moderators: Teresio Avitabile and Michele Reibaldi 6314 — D0185 Functional Expression Of TRPV Channels In The Retinal Endothelium. Jennifer E. McNaughten, M. McGahon, G. McGeown, T. M. Curtis. Queens University Belfast, Belfast, United Kingdom 6316 — D0187 Protective effects of an PPAR-γ agonist on retinal ischemia/reperfusion injury in rats. Xiaoyan Zhang, Y. Xiao, Y. Zhang, J. Zhang, W. Ye. Ophthalmology, Huashan Hospital affiliated to Shanghai Fudan University, Shanghai, China 6317 — D0188 Spectroscopic Investigation of Agonist-Induced Rearrangements of Cyclic Nucleotide-Regulated Ion Channels. William N. Zagotta1, M. C. Puljung1, S. Stoll2. 1Physiology and Biophysics, University of Washington, Seattle, WA; 2 Chemistry, University of Washington, Seattle, WA 6319 — D0190 Increased Expression of Endothelin B Receptors Precedes Retinal Ganglion Cell Death in a Rodent Model of Glaucoma. Alena Z. Minton1, 2, N. Phatak1, 2, D. L. Stankowska1, 2, S. He1, 2, H. Ma3, R. R. Krishnamoorthy1, 2. 1Cell Biology & Anatomy, University of North Texas Health Science Center, Fort Worth, TX; 2North Texas Eye Research Institute, Fort Worth, TX; 3Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 6320 — D0191 Vitreous penetration of orally administered acetazolamide in humans. Armin Afshar, R. Jager. Ophthalmology & Visual Science, University of Chicago, Chicago, IL 6321 — D0192 Quality of fixation in major depressive disorder and the influence of antipsychotic medication. Serena Fragiotta1, P. Grenga2, D. Domanico2, A. Cutini1, S. Valente1, V. De Rosa1, E. M. Vingolo1. 1University of Rome La Sapienza, Latina, Italy; 2S.M.Goretti Hospital, latina, Italy 6322 — D0193 Translational Regulation of RPE65 Expression by microRNA. William Samuel1, R. K. Kutty1, T. Duncan1, C. Jaworski1, T. Hara2, A. Lal2, T. Redmond1. 1Laboratory of Retinal Cell and Molecular Biology, National Eye Institute / National Institutes of Health, Bethesda, MD; 2Genetics Branch, National Cancer Institute / National Institutes of Health, Bethesda, MD 6323 — D0194 Decreased Protein Expression of P2X2 in the Retina of Type 1 Diabetic Rats Treated with Suramin and PPADS. Juan E. Gallo2, 1, J. Mancini2, 1, G. A. Ortiz2, J. O. Croxatto3. 1 Ophthalmology, Hospital Universitario Austral, Pilar, Argentina; 2Nanomedicine & Vision Group, Universidad Austral, Pilar, Argentina; 3Ocular Pathology, Fundacion Oftalmologica Argentina “Jorge Malbran”, Buenos Aires, Argentina *CR 6324 — D0195 Intracellular pH of Retinal Ganglion Cells During Systemic Hypoxia. Verleen K. McSween, S. Viswanathan, J. A. Bonanno, S. A. Burns, S. Li. School of Optometry, Indiana University, Bloomington, IN 6325 — D0196 Further Studies on the Inhibition of [3H]D-Aspartate Release by Hydrogen Sulfide Donors in Isolated Bovine Retina. Pratik Bankhele1, J. Jamil1, A. Salvi1, Y. Njie-Mbye2, M. S. Kulkarni2, S. E. Ohia2, C. A. Opere1. 1Creighton University, Omaha, NE; 2Texas Southern University, Houston, TX 6326 — D0197 Asymmetrical vitreous status in unilateral epimacular membrane observed by swept-source optical coherence tomography. Danjie Li, H. Itakura, S. Kishi. Ophthalmology, Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Japan 6327 — D0198 The Retina of the Cognitively Impaired Beagle Dog in Alzheimer’s Disease. Laura Emptage1, B. Milgram3, 5, H. Dobson3, 4, Z. Leonenko1, 6, M. C. Campbell1, 2. 1Physics and Astronomy, University of Waterloo, Waterloo, ON, Canada; 2School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada; 3CanCog Technologies, Fergus, ON, Canada; 4University of Guelph, Guelph, ON, Canada; 5University of Toronto at Scarborough, Scarborough, ON, Canada; 6Biology, University of Waterloo, Waterloo, ON, Canada *CR 6328 — D0199 Acid Sphingomyelinase: a novel target for ischemia-induced retinal degeneration. Jie Fan1, B. X. Wu2, C. E. Crosson1. 1 Ophthalmology-Storm Eye Inst, Medical Univ of South Carolina, Charleston, SC; 2Microbiology & Immunology, Medical University of South Carolina, Charleston, SC *CR 6329 — D0200 Retinal Expression of α-1-Antitrypsin (A1AT) in diabetic and non-diabetic rats. Gustavo A. Ortiz1, 3, J. Mancini1, 3, E. Chuluyan2, J. E. Gallo1, 3. 1Ciencias Biomédicas, Universidad Austral, Pilar, Argentina; 2 Farmacología, Universidad de Buenos Aires, Buenos Aires, Argentina; 3Nanomedicine & Vision Group, Universidad Austral, Pilar, Argentina *CR 6330 — D0201 Dietary profile and vitamin A intake in patients with Stargardt Disease and Retinitis Pigmentosa. Alba Miele1, A. Sodi1, G. Abbruzzese1, V. Murro1, F. Sofi3, 2, F. Cesari2, A. Gori2, R. Abbate2, A. Casini3, U. Menchini1. 1 Specialistic Surgical Sciences, Eye Clinic, University Of Florence, Italy, Florence, Italy, Italy; 2 Medical and Surgical Critical Care, University Of Florence, Florence, Italy; 3Agency of Nutrition, University Of Florence, Florence, Italy 6331 — D0202 Hypothermia protects retinal ganglion cells against ischemia. Maximilian Schultheiss, M. Blak, T. Dorfi, J. Hofmann, K. Bartz-Schmidt, S. Schnichels, M. S. Spitzer. Department of Ophthalmology, University of Tuebingen, Tuebingen, Germany *CR 6332 — D0203 Effect of Storage Temperature and Antioxidant Concentration on Catecholamine Stability. Randolph D. Glickman1, J. Berry1, 2, N. C. Kumar1. 1Dept of Ophthalmology, Univ of Texas Hlth Sci Ctr SA, San Antonio, TX; 2 Medical School, Baylor College of Medicine, Houston, TX 6333 — D0204 Establishment of a retinal ischemia organ culture model. Sven Schnichels, M. Blak, T. Dorfi, J. Hofmann, K. Bartz-Schmidt, F. Ziemssen, M. Schultheiss, M. S. Spitzer. University Eye Hosp Tuebingen, Centre for Ophthalmology Tuebingen, Tuebingen, Germany *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 393 Thursday Posters 10:30 am – 12:15 pm 6315 — D0186 Further Studies On The Role Of Arachidonic Acid Metabolites In The Regulation Of Potassium-Induced [3H]D-Aspartate Release From Isolated Bovine Retinae By 5-epi-5-F3tIsoprostane. Jamal Jamil1, P. Bankhele1, A. Salvi1, T. Durand3, J. Galano3, A. Guy3, Y. Njie-Mbye2, S. E. Ohia2, C. A. Opere1. 1Creighton.edu, Omaha, NE; 2Texas Southern University, Houston, TX; 3 Universities of Montpellier I and II, Montpellier cedex, France 6318 — D0189 Evaluation of homocysteine and its metabolic cofactors in patients with non proliferative and proliferative diabetic retinopathy. Giulia Malaguarnera1, C. Gagliano1, M. D. Toro1, F. Drago2, T. Avitabile1. 1Department of Ophthalmology, university of Catania, Catania, Italy; 2Department of Clinical Biomedicine, university of Catania, Catania, Italy 6334 – 6356 – Thursday – Posters 6334 — D0205 Effects Of Propofol Over Circular Retinal Spreading Depression. Vinicius V. Oliveira1, R. Fleming1, N. S. Calixto2, S. Cronemberger2, A. Dantas1. 1Biophysics Institute, Federal Univ of Rio de Janeiro, Rio de Janeiro, Brazil; 2Ophthalmology, Federal Univ of Minas Gerais, Belo Horizonte, Brazil 6335 — D0206 Roles of Nitric Oxide in Delta Opioid-Receptor Agonist (SNC 121) Mediated Retina Neuroprotection in Chronic Glaucoma Rat Model. Yasir Abdul, S. Husain. Ophthalmology, Medical Univ of South Carolina, Charleston, SC 6336 — D0207 Perinatal hypoxia-ischemia impairs retinal ganglion cell function and optokinetic behavior in a rat model. Nikolay P. Akimov, R. C. Renteria. Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 6337 — D0208 The effect of RGS9 overexpression on flicker responses of mouse bipolar cells. Christopher Fortenbach1, C. Kessler1, M. E. Burns1, 2. 1Center for Neuroscience and Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA; 2 Ophthalmology & Vision Science, University of California, Davis, Davis, CA 6338 — D0209 C-peptide injection had synergitic effect to precultured islets transplant in prevention of diabetic retinopathy. Chunzhi Dou1, 2, S. Y. Wu3, X. Zhang5, T. Dou6, G. Shuyan4. 1 Ophthalmology, Emory University, Suwanee, GA; 2Biology, Georgia University System, Lawrenceville, GA; 3Department of Surgery, Norman Bethune Medical School, Jilin University, Changchun, China; 4Department of Ophthalmology, Norman Bethune Medical School, Jilin University, Changchun, China; 5Endocrinology, Dehui County Hospital, Dehui, China; 6Clinical Chemistry, Genova Diagnostics, Duluth, GA Thursday Posters 10:30 am – 12:15 pm 6339 — D0210 Comparison of Dexmedetomidine vs. Propofol in Vitreoretinal Surgery Under Local Block. Linda Y. Huang1, A. Patel2, M. Antoniello2, C. Schoenberg2, D. Grech2, A. Davidow2, T. Xia2, N. Bhagat1. 1Ophthalmology and Visual Sciences, UMDNJ-New Jersey Medical School, Newark, NJ; 2Anesthesiology, UMDNJNew Jersey Medical School, Newark, NJ *CR, f 6340 — D0211 Sitagliptin prevents bloodretinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic animals. Andreia Gonçalves1, E. C. Leal2, A. Paiva3, C. F. Ribeiro1, F. Reis1, A. F. Ambrosio2, 4, R. Fernandes1. 1Lab Pharmacology and Experimental Therapeutics, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Portugal; 2Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; 3 Histocompatibility Centre of Coimbra, Coimbra University Hospitals, Coimbra, Portugal; 4Centre of Ophthalmology and Vision Sciences, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Portugal 6341 — D0212 Inhibition of the diabetesinduced increased TGF-β signaling in retinal vessels leads to an abnormal endothelial phenotype. Zeina Dagher, J. Vaz, M. Goodridge, C. Gerhardinger, M. Lorenzi. Schepens Eye Research Institute, Massachusetts Eye & Ear, Boston, MA 6342 — D0213 Expression of 2PK+ leak channels in ganglion cells of the mouse retina. Steven Hughes, R. G. Foster, S. N. Peirson, M. W. Hankins. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom 6343 — D0214 Glucocorticoids Inhibit p38MAPK Activation and Neuronal Apoptosis in Early Diabetic Retinopathy. Xinyuan Zhang1, B. Bao2, M. C. Gillies3. 1Tongren Eye Center, Beijing Tongren Hospital, Beijing, China; 2Pathology, The University of Sydney, Sydney, NSW, Australia; 3 Ophthalmology, The University of Sydney, Sydney, NSW, Australia *CR 6344 — D0215 The molecular mechanisms of store-operated calcium entry in Müller glia. Tunde Molnar1, A. M. Frye1, P. Barabas1, D. A. Ryskamp2, 1, D. Krizaj1, 3. 1Ophthalmology and Visual Sciences, Moran Eye Institution, University of Utah School of Medicine, Salt Lake City, UT; 2 Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, UT; 3Department of Physiology, University of Utah, Salt Lake City, UT 6345 — D0216 Contribution of GPCRs and NADPH oxidase to increased generation of superoxide by retinal photoreceptor cells in elevated glucose. Yunpeng Du1, M. Cramer1, K. Palczewski2, T. S. Kern1, 3. 1Medicine, Case Western Reserve University, Cleveland, OH; 2Pharmacology, Case Western Reserve University, Cleveland, OH; 3Stokes Veterans Administration Hospital, Cleveland, OH *CR 6346 — D0217 Pro-NGF induces endothelial cell death via the P75 neurotrophin receptor (P75NTR) in a mouse model of oxygeninduced retinopathy (OIR). Nicholas Sitaras1, 2, H. Saragovi4, S. Chemtob3, 2, P. Sapieha2. 1 Pharmacology, Maisonneuve-Rosemont Hospital, Montréal-Est, QC, Canada; 2Ophthalmology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada; 3Pharmacology, CHU Sainte-Justine, Montreal, QC, Canada; 4Pharmacology and Therapeutics, Lady Davis Institute, Montreal, QC, Canada *CR 6347 — D0218 Inner nuclear layer microcystic changes in optic nerve atrophy: a prospective study. Benjamin Wolff, V. Vasseur, C. Basdekidou, J. A. Sahel, C. Vignal, M. Mauget-Faÿsse. Professor Sahel Dept, Fondation ophthalmologic Rothschild, Paris, France *CR 6348 — D0219 Adrenergic but not purinergic receptors affect ion transport across the mouse retinal pigment epithelium. Thor Eysteinsson, S. B. Skarphedinsdottir, S. Arnason. Physiology, University of Iceland, Reykjavik, Iceland *CR 6349 — D0220 Increased Endothelin A Receptor Expression in Rat Model of Ocular Hypertension. Nolan R. McGrady1, 2, A. Z. Minton1, 2, R. R. Krishnamoorthy1, 2. 1Cell Biology & Anatomy, UNT Health Science Center, Fort Worth, TX; 2North Texas Eye Research Institute, Fort Worth, TX 6350 — D0221 Protective Effects of Chitosan on Ischemia-Reperfusion Injury in Rat Retina. Sheng-Li Cho1, C. Yang2. 1National Taiwan University College of Medicine, Taipei, Taiwan; 2 Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan 6351 — D0222 Water-dispersible hesperetin prevents ganglion cell loss in the retina after retinal ischemia reperfusion injury. Akito Shimouchi1, H. Yokota1, T. Nagaoka1, S. Ono1, H. Takumi2, S. Narayanan3, R. B. Caldwell3, 4, A. Yoshida1. 1Ophthalmology, Asahikawa Medical University, Asahikawa, Japan; 2Institute of Health Science, Ezaki Glico Co., Ltd, Osaka, Japan; 3 Vascular Biology Center, Medical College of Georgia, Augusta, Georgia; 4VA Medical Center, Augusta, Georgia *CR 6352 — D0223 Hypoxia Affects Polarized Secretion of Amyloid Precursor Protein from Retinal Pigmented Epithelial Cells. Mary C. McGahan, S. Nagar, M. Lall. Dept of Molec Biomed Sci, North Carolina State University, Raleigh, NC 6353 — D0224 Stimulation of the AMPA Receptor in Retinal Ganglion Cells Increases Phosphorylation of CREB. Yong H. Park1, 2, B. H. Mueller1, 2, H. Ma1, 2, T. Yorio1, 2. 1Pharmacology & Neuroscience, UNT Health Science Center, Fort Worth, TX; 2North Texas Eye Research Institute, Fort Worth, TX 6354 — D0225 Specific Expression of Erythrocyte tropomodulin in the retina of E-Tmod+/lacZ and E-Tmod-/- mice. Lin Xie1, L. Sung2. 1Department of Ophthalmology, DaPing Hospital of the Third Military Medical University, Chongqing, China; 2Department of Bioengineering, and Center for Molecular Genetics, University of California, San Diego, CA 6355 — D0226 The Effects Of Brimonidine On Retinal Spreading Depression. Renata Fleming1, V. V. Oliveira1, G. Alencar1, N. S. Calixto2, S. Cronemberger2, P. Gardino1, A. Dantas1. 1Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 2 Universidade Federal de Minas Gerais, Belo Horizonte, Brazil 6356 — D0227 Protective Effects of Renin Inhibitor in Retinal Ischemia-reperfusion Injury. Kazuyuki Hirooka, K. Tenkumo, E. Nitta, T. Fujita, F. Shiraga. Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 394 Thursday – Posters – 6357 – 6381 6357 — D0228 Brn3b mediated regeneration of the optic nerve in a rodent model of glaucoma. Dorota L. Stankowska, A. Z. Minton, R. R. Krishnamoorthy. Cell Biology and Anatomy, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 6358 — D0229 Extracellular Hsp70 Mediates Ischemia-Induced Retinal Damage Through A Tlr4-Dependent Pathway. Galina Dvoriantchikova, A. C. Santos, X. Dvoriantchikova, E. P. Hernandez, D. V. Ivanov. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 6359 — D0230 AP-1 and C/EBPβ Regulate Endothelin B (ETB) Receptor in Retinas of Rats in Response to Elevated Intraocular Pressure. Shaoqing He1, A. Z. Minton1, H. Ma2, R. R. Krishnamoorthy1. 1Cell Biology and Anatomy, University of North Texas Hlth Sci Ctr, Fort Worth, TX; 2Pharmacology and Neurosciences, University of North Texas Hlth Sci Ctr, Fort Worth, TX 6360 — D0231 Mineralocorticoid receptor antagonists for the treatment of central serous chorioretinopathy: Mechanistic rationale. Francine F. Behar-Cohen1, 3, I. Celerier2, E. Bousquet3, 1, J. P. Jeanny3, F. Jaisser2, N. Farman2. 1 Ophthalmology, Hotel Dieu de Paris, Universite Paris Descartes, Paris, France; 2UMRS872 Team1, Inserm, Paris, France; 3UMRS 872 Team 17, Inserm, Paris, France *CR 6361 — D0232 Ocular changes in a rat model of Alzheimer’s Disease. YuChun Tsai1, B. Lu1, S. Girman1, C. Svendsen1, R. M. Cohen2, S. Wang1. 1 Cedars-Sinai Medical Center, Los Angeles, CA; 2 Memory Disorders Center, Cedars-Sinai Medical Center, Los Angeles, CA 6362 — D0233 QLT091001, a 9-cis-retinal analog, is well tolerated by retinas of mice with impaired visual cycles. Tadao Maeda1, Z. Dong3, H. Jin3, O. Sawada2, S. Gao2, G. Palczewska3, K. Palczewski2. 1Ophthalmology & Visual Sciences, Case Western Reserve University, Cleveland, OH; 2 Pharmacology, Case Western Reserve University, Cleveland, OH; 3Polgenix Inc., Cleveland, OH *CR 6363 — D0234 Topical Bromfenac 0.1% suppresses Concanavalin-A Induced Blood Retinal Barrier Breakdown. Hiroaki Takahashi, T. Kida, S. Kozai, H. Tokushige. Research Laboratory for Drug Development, Senju Pharmaceutical Co, Ltd, Kobe, Japan *CR Exhibit Hall D0277-D0293 Thursday, May 09, 2013 10:30 AM-12:15 PM Eye Movements / Strabismus / Amblyopia / Neuro-Ophthalmology 546 Oculoplastics: Eyelids Moderator: Benjamin Thompson 6366 — D0277 A retrospective study of chalazia in an urban tertiary care setting. Christopher Lo, A. Y. Wu. Ophthalmology, Mount Sinai, New York, NY 6367 — D0278 Clinical Pathology of Pediatric Ptosis. Femida Kherani, E. Sanders, H. Sarnat. University of Calgary, Calgary, AB, Canada 6368 — D0279 Comparison Of 10% Phenylephrine Test with Manual Elevation Test in Patients with Bilateral Involutional Ptosis. Ivana Pereira, S. Matayoshi. Ophthalmology, University Sao Paulo, Sao Paulo, Brazil 6369 — D0280 Ptosis following long term topical steroid use after cornea graft surgery. Amanjeet Sandhu, L. C. Clarke, F. C. Figueiredo. Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom 6370 — D0281 Effect of brow fixation in evaluation of eyelid position and levator palpebrae superioris function. Elysa A. Brown, A. Y. Ting, I. Koreen, R. Yeatts. Ophthalmology, Wake Forest Medical Center, Winston Salem, NC 6371 — D0282 Management of Malignant Eyelid Tumors by Primary Reconstruction: Evaluation of Long-term Outcomes. Yinan Han1, J. Qian1, Y. Yuan1, Y. Bi1, Y. Yao1, K. Xue1, C. Wei2, J. Guo1. 1Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China; 2 Ophthalmology, Yijishan Hospital of Wannan Medical College, Wuhu, China 6372 — D0283 Simplified horizontal mattress full-thickness eyelid defect repair. Julia E. Reid1, C. N. Czyz2, K. R. Everman2, K. V. Cahill2, J. A. Foster2, S. X. Zhang-Nunes2. 1Department of Ophthalmology and Visual Sciences, The Ohio State University, Columbus, OH; 2The Eye Center of Columbus, Columbus, OH 6373 — D0284 Horizontal Tarsal Transposition Flap and Lateral Canthal Fixation for Repair of Large, Central Lower Eyelid Defects. Clifton Blake Perry, K. D. Carter, R. C. Allen. Ophthalmology, University of Iowa, Iowa City, IA 6374 — D0285 A modified staged surgical intervention for blepharophimosis-ptosisepicanthus inversus syndrome: 125 cases with encouraging results. Xin Song, X. Fan. Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 6375 — D0286 Lower eyelid surgical approach in facial paralysis. Fabiola Ogaz, G. Salcedo, R. O. Prieto, A. Buigues, L. Guakil. Asociacion para Evitar la Ceguera en Mexico, mexico, Mexico 6376 — D0287 Comparison of Fasanella-Servat and Small-Incision Techniques for Involutional Ptosis Repair. Mahsa A. Sohrab, G. Lissner. Ophthalmology, Northwestern University, Chicago, IL 6377 — D0288 Frontalis Suspension for Blepharoptosis Surgery, Is there a best material? Cristian M. Montecinos, R. O. Prieto, A. Ceriotto, A. Buigues, A. I. Ortiz, G. Salcedo. APEC, Distrito Federal, Mexico 6378 — D0289 Use of Histoacryl as a Spacer in the Recession of Upper Eyelid Retraction. Imtiaz A. Chaudhry1, O. Al-Shaikh2, W. A. Al-Rashed3, F. A. Shamsi4, Y. O. Arat5, M. Boniuk6. 1Houston Oculoplastics Associates, Memorial Herman Medical Plaza Texas Medical Center, Houston, TX; 2 Oculoplastic and Orbit Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 3Vice Dean, Faculty of Medicine, Imam Ibn Mohammad Saud Islamic University, Riyadh, Saudi Arabia; 4 Research Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 5Department of Ophthalmology, University of Wisconsin School of Medicine, Madison, WI; 6Ophthalmology, Baylor College of Medicine, Houston, TX 6379 — D0290 Use of Omentum for Engineering in vivo Levator Palpebrae Superioris: A Pilot Study. Sara L. Duke, P. Bu, D. K. Yoo. Ophthalmology, Loyola University Chicago, Maywood, IL 6380 — D0291 Biointegration of Osteomesh® Polycaprolactone Implants in the Rabbit Eyelid. Livia Teo1, S. Teoh2, L. Seah1. 1Oculoplastics, Singapore National Eye Center, Singapore, Singapore; 2Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore *CR 6381 — D0292 The Effects of Temperaturesensitive Guardix SG® in Adhesiolysis of Experimentally Induced Lid Adhesion Rabbits. Hee-Bae Ahn1, H. Jung1, M. Roh2, W. Ryu1, Y. Kwon1. 1ophthalmology, Dong-A university, Busan, Republic of Korea; 2pathology, Dong-A university, Busan, Republic of Korea f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 395 Thursday Posters 10:30 am – 12:15 pm 6364 — D0235 Overexpression of the POU Domain Transcription Factor, Brn3b Causes Neurite Outgrowth in Cultured PC 12 Cells. Nitasha Phatak, D. L. Stankowska, R. R. Krishnamoorthy. UNT Health Science Center, Fort Worth, TX 6365 — D0236 MicroRNAs in vitreous humor from patients with ocular disease : preliminary results. Caterina Gagliano1, A. Russo2, M. Ragusa4, R. Caltabiano3, L. Puzzo3, T. Avitabile2, A. Longo2, M. D. Toro2, M. Purrello4, M. Reibaldi2. 1 Ophthalmology, NEST (Neurovisual Science Technology), Catania, Italy; 2Opthalmology, University of Catania, Catania, Italy; 3Pathological Anatomy, University of Catania, Catania, Italy; 4 Molecular Biology, University of Catania, Catania, Italy 6382 – Thursday – Posters Thursday Posters 10:30 am – 12:15 pm 6382 — D0293 The Efficacy of Seprafilm® Graft with Adhesiolysis in Experimentally Induced Lid Adhesion in Rabbits. Hyemi Jung1, H. Ahn1, M. Roh2, W. Ryu1, Y. Kwon1. 1Department of Ophthalmology, Dong-A University College of Medicine, Busan, Republic of Korea; 2pathology, Dong-A University College of Medicine, Busan, Republic of Korea The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 396 Thursday – Keynote – 6383 6B Thursday, May 09, 2013 2:00 PM-3:15 PM 548 ARVO/Alcon Keynote Series The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) is a systematic, scientific effort to quantify the comparative magnitude of health loss due to diseases, injuries and risk factors by age, sex and geography for specific points in time. Drawing on the efforts of a multitude of people, including almost 500 coauthors around the world, the study represents the largest review of epidemiological data sources relevant to burden of disease. After a complete systematic assessment of the data on all diseases and injuries, we have expanded the number of data sources in our analysis significantly. GBD studies for 1990 and 2000 examined 108 diseases and causes in 8 regions and 170 diseases and causes in 14 regions respectively. The GBD 2010 study expands the scope much further to 291 diseases and injuries and 67 risk factors in 21 individually distinct but collectively comprehensive global regions. At the same time, we have improved upon estimation methods significantly. Amongst the important differences: we have utilized population level surveys to help derive health severity weights; have used highly advanced published methods to establish mortality by age and sex; and have radically improved the modeling techniques used for estimating incidence, prevalence and causes of death. We have created new estimates for 1990 using these techniques and the widely expanded data available to us so that we can assess comparable time trends with the best possible science. This presentation will highlight key findings from the GBD 2010, with a focus on vision loss in the context of the other diseases, injuries and risk factors studied, to demonstrate this impairment’s global impact over the past two decades and implications for future vision research. Murray is a scholar in global health and public health at the University of Washington and is the director of IHME. He previously served as director of the Harvard Initiative for Global Health and executive director of the Evidence and Information for Policy Cluster at the World Health Organization. At IHME, Murray’s work has included studying adult and child mortality, costs of various health interventions, and continuing work with colleagues at Harvard, WHO and elsewhere on the global burden of disease project. Thursday Keynote 2:00 pm – 3:15 pm 6383 — 2:00 Global Burden of Disease Study 2010: Key Findings and Implications for Vision Research. Christopher Murray. Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 397 NOTES NOTES _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ 398 266