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Variations and Control of Cellular Respiration Figure 9.16 Electron shuttles span membrane 2 NADH Glycolysis 2 Pyruvate Glucose MITOCHONDRION 2 NADH or 2 FADH2 2 NADH Pyruvate oxidation 2 Acetyl CoA 2 ATP Maximum per glucose: CYTOSOL 6 NADH 2 FADH2 Citric acid cycle Oxidative phosphorylation: electron transport and chemiosmosis 2 ATP about 26 or 28 ATP About 30 or 32 ATP Figure 9.18 Glucose CYTOSOL Glycolysis Pyruvate No O2 present: Fermentation O2 present: Aerobic cellular respiration MITOCHONDRION Ethanol, lactate, or other products Acetyl CoA Citric acid cycle Figure 9.17a 2 ADP 2 P i Glucose 2 ATP Glycolysis 2 Pyruvate 2 NAD 2 Ethanol (a) Alcohol fermentation 2 NADH 2 H 2 CO2 2 Acetaldehyde Figure 41.18 2 Reticulum 1 Rumen Esophagus Intestine 4 Abomasum 3 Omasum Figure 9.17b 2 ADP 2 P i Glucose 2 ATP Glycolysis 2 NAD 2 NADH 2 H 2 Pyruvate 2 Lactate (b) Lactic acid fermentation Figure 9.19 Proteins Carbohydrates Amino acids Sugars Glycolysis Glucose Glyceraldehyde 3- P NH3 Pyruvate Acetyl CoA Citric acid cycle Oxidative phosphorylation Fats Glycerol Fatty acids Figure 9.20 Glucose AMP Glycolysis Fructose 6-phosphate Stimulates Phosphofructokinase Fructose 1,6-bisphosphate Inhibits Inhibits Pyruvate ATP Citrate Acetyl CoA Citric acid cycle Oxidative phosphorylation Figure 45.7-2 Epinephrine Adenylyl cyclase G protein G protein-coupled receptor GTP ATP cAMP Inhibition of glycogen synthesis Promotion of glycogen breakdown Protein kinase A Second messenger Figure 41.20 Transport of glucose into body cells and storage of glucose as glycogen Pancreas secretes insulin. Stimulus: Blood glucose level rises after eating. Homeostasis: 70–110 mg glucose/ 100 mL blood Breakdown of glycogen and release of glucose into blood Stimulus: Blood glucose level drops below set point. Pancreas secretes glucagon.