Survey
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
Institutionen för Odontologi Medicine Magisterexamen i Odontologi Master of Medical Science in Odontology Interceptive orthodontic care in Uppsala County A retrospective study on frequency of interceptive treatment, treatment approaches and treatment providers Sarit Silkestrand Stockholm 2007 Nr 121 Interceptiv ortodonti i Uppsala län En retrospektiv studie av frekvensen interceptiv behandling, behandlingsmetod och behandlare Sammanfattning Bakgrund: Vid de två regionala specialistklinikerna i Uppsala län tillämpas olika behandlingskoncept. I Region 1 som är en större tätort, sker den interceptiva behandlingen rutinmässigt vid allmäntandvårdsklinikerna. I Region 2 som är en mindre tätort, sker den interceptiva behandlingen oftare vid specialistkliniken. Syfte: Att undersöka frekvensen av ortodontikonsultationer, den interceptiva behandlingen vid allmäntandvårdsklinikerna samt att visa distributionen av ortodontiska behandlare i Uppsala län. Material & Metod: Från tretton allmäntandvårdskliniker i Uppsala län selekterades totalt 616 journaler systematiskt från patienter födda 1989. Ett protokoll användes för att hämta in uppgifter från journalerna. Binomial fördelningsanalys användes för att jämföra mellan regionerna samt mellan pojkar och flickor i grupperna; icke-behandlade, allmäntandläkar-behandlade och specialist-behandlade. Resultat: Fyrtio-åtta procent av patienterna erhöll ortodontikonsultation. Inga signifikanta könsskillnader kunde påvisas vad gällde behandlingsgrupperna. I bägge regionerna utförde glesbygdsklinikerna proportionellt mer interceptiv behandling jämfört med stadsklinikerna i bägge regionerna (p<0.05). I Region 2 utfördes mer interceptiv behandling vid specialistkliniken jämfört med vid specialistkliniken i Region 1 (p<0.01). Konklusioner: På grund av de olika behandlingskoncepten vid de regionala specialistklinikerna visar allmäntandvårdsklinikerna i bägge regionerna olika distribution av ortodontiska behandlare. Även närhet till respektive specialistklinik föreföll påverka både valet av behandlingsmetod och behandlare. Handledare: Lena Berglund-Stevenberg och Eva Hellsing, Avd för Ortodonti, Institutionen för Odontologi, Karolinska Institutet, Stockholm Examinator: Professor, Anders Gustafsson, Avd för parodontologi, Institutionen för Odontologi, Karolinska Institutet, Stockholm Abstract Background: At the two regional specialist clinics in Uppsala County different treatment concepts are practised. In Region 1, a large urban area, the interceptive treatment is routinely performed at the general dental clinics. In Region 2, a small urban area, the interceptive treatment is more often performed at the specialist clinic. Aim: To evaluate the frequency of orthodontic consultation, the given interceptive orthodontic treatment at the general dental clinics and to show the distribution of treatment providers in Uppsala County. Material & Methods: From thirteen public general dental clinics in Uppsala County a total sample of 616 records were systematically selected from patients born 1989. A standardized protocol was used to collect data. Binomial test was used to compare between the two regions and between girls and boys in the non treatment group, general dental practitioner treated group and orthodontist treated group. Results: Forty-eight percent of the patients received orthodontic consultation. No significant gender differences were found concerning the groups. In both regions the rural clinics did proportionally more interceptive treatment compared to the urban clinics in both regions (p<0.05). In Region 2 more interceptive treatment was carried out at the specialist clinic compared to at the specialist clinic in Region 1 (p<0.01). Conclusions: Due to different treatment concepts at the regional specialist clinics, the general dental clinics in both regions show different distribution of orthodontic providers. In addition, proximity to respective specialist clinic appeared to influence choice of orthodontic treatment and treatment provider. Keywords Interceptive orthodontics, Preventive orthodontics, Public dental service, Orthodontic consultation, Sweden Introduction Definition of interceptive orthodontic treatment Interceptive orthodontic treatment is generally defined as treatment aimed to eliminate or reduce unfavourable ongoing signs of malocclusion, thus providing favourable conditions for normal growth. In the literature it has been defined as “fostering developmental changes which are favourable and halting or minimizing those that are not” (Richardson 1999), “procedures that eliminate or reduce the severity of malocclusion” (Popovich 1973) or “any treatment in the mixed dentition which will prevent the establishment of a malocclusion” (Bass 1996). The term preventive orthodontics can also be seen in the literature, which is similar to interceptive treatment but is one step before, which means that the treatment is applied prophylactic, for example using a space maintainer to prevent crowding. For simplicity, in this study preventive orthodontics is also included in our definition of interceptive orthodontics. Treatment goal of interceptive orthodontic treatment Unpredicted growth in the late adolescence or ectopic eruption of permanent teeth may lead to the need of further treatment in the permanent dentition. Persisting habits may likewise jeopardize treatment success. The orthodontic provider must be aware of these factors and as well evaluate the patient’s compliance as many interceptive appliances and methods rely entirely on the patient’s and parents’ cooperation (Wong et al. 2004). Performed correctly, interceptive orthodontic treatment may reduce the risk for developing facial asymmetry, functional jaw displacements, severe crowding and future complex or prolonged treatment. Interceptive orthodontic treatment is based on early detections of malocclusions followed by orthodontic referrals or consultations for therapy planning. Knowledge of normal dentofacial growth is fundamental for correct diagnosis and treatment planning. It is not the main goal for interceptive orthodontics to achieve straight arches or perfect tooth aligning, but rather to promote favourable dentofacial growth. Interceptive treatment is performed in the mixed dentition. Growth adaptation of discrepancies in the jaw relations using functional appliances during growth peak is often regarded as interceptive treatment. Extractions to relieve severe future crowding starting in the mixed dentition are an often-used interceptive intervention. Removable appliances are frequently used as an interceptive measure but with these appliances only tipping movements can be achieved. Severe discrepancies of jaw relations and crowding in the permanent dentition are beyond the capacities of interceptive orthodontics. These problems require comprehensive treatment and are often delayed until permanent dentition is present. Methods suitable for interception should be easy and cost-effective. For example: grinding, extractions, removable plates, cross-elastics and lingual appliances such as quad-helix. Other examples of interceptive treatment are, the simple and sometimes forgotten methods such as behavioural management (for sucking habits), lip exercises and spatula biting (for functional anterior cross bites). Space maintainers are often included in interceptive treatment but since they have to be used for many years and this 5 subsequently means long time of treatment resources, it can hardly be categorized as an easy and cost-effective treatment. Functional appliances are well documented in the literature and have best effect in Class II malocclusions but it is questioned if they can be categorized as interceptive treatment. By tradition functional appliances are often used in the general dental clinics but the treatment goal to correct the over jet is not always reached and in one third of the patients there is residual need for a second treatment with fixed appliance due to poor treatment results or relapse (Follin et al. 1993, Rizell et al. 2006). Most of the interceptive methods described above are dependent on existing growth and can been seen as guidance for normal growth. Review of the literature The interceptive treatments should be confined to simple, mixed dentition cases to ensure cost-effective results according to Kerr et al. (1996) who studied the use of removable appliances in the Public Dental Service (PDS) in Scotland. In a county in Sweden with sufficient specialist resources, a positive correlation to the outcome of orthodontic care in children treated by both specialists and general dental practitioners (GDPs) was shown. In counties with insufficient orthodontic resources fewer and later treatments were started. To compensate for lack of resources more treatments by GDPs were initiated and the outcome from these counties with less resources resulted in reduced quality, especially the treatments by GDPs. As a result, counties with lesser resources had higher persisting treatment need and higher desire for further treatment (Bergstrom & Halling 1996). 6 In Northern Ireland a study which aim was to test the effectiveness of interceptive orthodontics in the general dental clinics showed, at the end of treatment in 9-11-yearold children who completed the interceptive treatment, a reduction in IOTN grades 4 and 5 from 69 percent at baseline to 42 percent (al Nimri & Richardson 2000). In this study the authors used a specially designed plastic gauge (IOTN-gauge) to measure for example over jet and the distance between the distal surface of the lateral incisor and the mesial surface of the first permanent molar as a predictor for crowding and the need for subsequent treatment. This is in agreement with conclusions made by Vakiparta et al. (2005) who suggest that systematically applied early treatment contributes to a reduction in later treatment need. Orthodontic treatment need and malocclusions Orthodontic treatment need in children has been reported to be one fourth to one third of the studied population, see Table 1. These figures are based on varying definitions and variables but altogether around one third of the children would benefit from treatment. Permert and colleagues (1998) reported, that in their study of the children who were seen by an orthodontist, 29 percent benefited from interceptive treatment without appliances, that is by extractions and grinding alone. Prevalence of malocclusions in the deciduous and mixed dentition where interception could be applicable is presented in Table 2. According to al Nimri and Richardson (2000) the most favourable ages for interception are between 9 and 11 years of age. These are ages in the mixed dentition when both hard and soft tissues can advantageously be influenced. Also most dental traumatic injuries occur in these ages (Borssen & Holm 1997). The most common malocclusions and their contemporary treatments will be described briefly below from an interceptive perspective. 7 Table 1. Orthodontic treatment need in the deciduous and mixed dentition in different countries. % n Age (yrs) Index Country Authors Al Nimri et al. 2000 Heikinheimo et al. 1987 Bassler-Zeltman 1998 Karaiskos et al. 2005 Heikinheimo 1978 Hannuksela 1977 Onyeaso 2004 Hosseini et al. 1999 Tausche et al. 2004 Linder-Aronson et al. 2002 Mugonzibwa et al. 2004 33 2,002 20.4 184 32 1,020 28 395 23.5 200 25.6 1,200 27 493 32 174 26.2 1,975 25.7 1,281 15.9 202 21.1 166 22.2 180 1. IOTN = Index of Orthodontic Treatment Need 2. FMB = Finnish Medical Board, 10-grade scale 3. SNBH = Swedish National Board of Health, 4-grade scale 4. IPION = Index for Preventive and Interceptive Orthodontic Needs IOTN1 FMB2 SNBH3 IPION4 FMB SNBH IOTN SNBH IOTN SNBH IOTN 9-11 5 9 6-9 7 9 7-10 9 6-8 8-16 3-5 6-8 9-11 England Finland Germany Kanada Finland Finland Nigeria Sweden Germany Sweden Tanzania Table 2. Prevalence of malocclusion in the deciduous and mixed dentition in different countries. Authors Thilander et al. Stahl & Grabowski Keski et Bassler et Schopf Tschill et 2001 2003 al. 2003 al. 1998 2003 al. 1997 Country Colombia Germany Finland Germany Germany France Dentition Deciduous Mixed Deciduous Mixed Onset Mixed Onset of Deciduous of Mixed Mixed n 373 2,910 1,225 7,644 486 1,020 2,326 789 Class II 15.5 Class III 2.9 Over jet 14.7 ≥ 4mm Overbite 18 ≥ 4mm Open bite 10.7 Posterior 7.2 cross bite Crowding 17.4 n/r = not recorded 22.7 3.7 27.4 21 0.2 16.8 21 0.4 13.8 33 1.5 26.7 40 4 14 27 3.5 27 26 0.5 16.7 23.6 15 19 33.8 26.4 20.7 n/r 20.1 3.9 6.7 3.9 2.8 3.1 4.6 7.5 3.5 17 8.0 7.8 n/r 16 53.1 2.4 20 51 53.4 26.3 n/r 8 Crowding Crowding is one of the most frequent orthodontic diagnoses. Signs of potential crowding in the permanent dentition observed in the deciduous dentition are incisor crowding, premature exfoliation and lack of approximal spacing. Good caries prevention is fundamental to avoid extractions of severely decayed teeth and consequently risk of space loss due to mesial drift. Most of the space loss (that is tooth drifting) after premature loss of a deciduous tooth occurs within six months and is more pronounced in the maxilla than in the mandible (Terlaje & Donly 2001, Richardson 1965, Northaway et al. 1994). It has been shown that losses of primary molars after 7.5 years of age had little effect on the relative space (Ronnerman 1977). In cases with risk of severe crowding it is inadvisable to use space maintainers, as extractions will be required later (Proffit 2000). Another study however, points out that predicting crowding in the mixed dentition is difficult (Maj et al. 1979). According to the authors where the lack of space for mandibular incisors exceeds 3.5 mm the results of nonextraction treatment were unsatisfactory (Maj et al. 1979). Approximal grinding as guidance of eruption can be applicable in many cases, instead of comprehensive serial extraction. Nevertheless, serial extraction can be beneficial and save later treatment time in cases with severe crowding (Little et al. 1990). One should be reminded that although extraction leads to relief of crowding it also reduces arch perimeter (Kau et al. 2004). Therefore, extraction of lower primary canines to reduce incisor crowding may be looked upon as a start of serial extraction. Other ways that does not involve extraction is the lip bumper appliance. Several studies have documented lip bumper as a reliable method to lessen mild to moderate crowding and for gaining arch length (Solomon et al. 2006, Davidovitch et al. 1997, Gerety 1997, Werner et al. 1994, Osborn et al. 1991, 9 Murphy et al. 2003). However, the documentations of the long-term stability of the lip bumper alone are scarce. Later in the mixed dentition the use of headgear and expansion appliances may further reduce crowding by space gain. Cross bites Cross bites occurs as anterior or posterior cross bites. Both types may also be associated with mandibular sliding from retruded to intercuspid position, also called functional cross bites. Prevalence of posterior cross bites has been reported to be about 11% (Thilander & Myrberg 1973). The most common type is a single-tooth unilateral cross bite whereas bilateral cross bite being the least usual type. The etiology behind the malocclusion is considered to be sucking habits, occlusal interferences, nasal obstruction and consequently mouth breathing (Larsson 1975, Corruccini et al. 1985). There is a consensus among professional clinicians that cross bites, especially functional cross bites, should be treated early (Kutin & Hawes 1969, Helm 1970, Pirttiniemi 1994, Kennedy & Osepchook 2005, Castaner-Peiro 2006). Risks with untreated cross bites are maxillary growth restriction, facial asymmetry and temperomandibular disorders (Egermark-Eriksson et al. 1990, Nerder et al. 1999). The latter may be seen in patients chewing only on one side due to the cross bite, which can lead to tempero-mandibular symptoms (Thilander et al. 2002). An article by Castaner-Peiro (2006) points out the importance of correct diagnosis. The article concludes that identifying between dento-alveolar and skeletal posterior cross bites are essential in determining treatment approach. Grinding, as an early treatment in the deciduous dentition appears to be the initial treatment of choice. A study in the mixed dentition showed that grinding is most 10 effective when the maxillary inter canine width is 3.3 mm wider than the corresponding width in the mandible (Lindner 1989). Under these circumstances the success rate was 90 percent according to the author. In a later follow-up study with the same subjects at the age of twenty years, 57 percent of those who received grinding treatment showed a stable correction of the cross bite (Tsaraptsani et al. 1999). Spontaneous corrections of unilateral cross bites do occur after cessation of sucking habits. Kurol and Berglund (1992) reported that in their study, that of the 3-5- year-old children with cross bites in the primary dentition, 45 percent in the untreated group showed spontaneous correction of posterior cross bites ten years later in the permanent dentition. This spontaneous correction rate is much higher than the 21 percent and 17 percent reported by other authors (Thilander et al. 1984, Lindner 1989). Grinding and expansion plates as treatment of unilateral functional cross bites in 4-yearolds had similar treatment success rates of 60 percent as in a 16-year follow-up study (Larsson 1986). Kurol and Berglund (1992) reported that grinding alone had a success rate of 64 percent (21/33). Later in the mixed dentition quad-helix and expansion plates can be recommended. A recent review reports that an evidence-based conclusion can not be drawn in determining which treatment modality is the most effective in treatment of posterior cross bites (Petren et al. 2003). However, several studies included in the review recommended the quad-helix because the authors found the appliance to be the most cost-effective. 11 Class II malocclusions One of the most important reasons for treating a large over jet is the potential trauma risk of the upper permanent incisors. Also the positive psychosocial impact with reduced over jet should be reminded. Most dental traumas occur in 8-11-year-olds (Borssen & Holm 1997). Over jets of more than 5 mm combined with incompetent lips were found to have a significant correlation with trauma to the upper incisors (Andrup et al. 1999, Jarvinen 1979, Burden 1995, Forsberg & Tedestam 1993). Other studies have implied that due to changed ways of living for children today with less physical activities and spending more time with computer games, the incidents of trauma have decreased (Petti et al. 1997, Petti & Tarsitani 1996). These findings concern particularly obese children, however, these obese children were less skillful and subsequently more prone to trauma when they fell or sustained impacts compared to more physically active children. The ideal treatment timing for Class II malocclusions would be during the adolescent growth spurt. Treatment is sometimes divided into two stages, where stage one aims to reduce the over jet and stage two is comprehensive fixed appliances. Three large randomised clinical trials of early two-stage versus later one-stage Class II treatment have recently been published in the USA and UK. From these studies it can be concluded that after the stage two treatment, there were no significant differences between early two-stage treated patients and later one-stage treated patients in any variable the studies evaluated. This means early treatment for Class II malocclusion is not more effective or efficient, other than producing an early positive change in selfesteem, compared to later one-stage treatment (Wheeler et al. 2002, Tulloch et al. 2004, Ghafari et al. 1998, O’Brien 2006). Ample evidence proves the effectiveness of 12 functional appliances such as the Twin-block (Jena et al. 2006, O’Brien et al. 2003, Illing et al. 1998, Dyer et al. 2001), Bionator (Jena et al. 2006, Illing et al. 1998, Jacobs & Sawaengkit 2002), Teuscher activator (Singh & Thind 2003) and Bass (Illing et al. 1998, Cura & Sarac 1997). The problems with removable appliances are that the treatment result is totally dependent on cooperation and this is very rarely fully achieved. The treatment result with the Herbst appliance, which is a fixed functional appliance, is remarkably better (O’Brien et al. 2003, Pancherz 1997). Of all the removable functional appliances it should be noted that the Twin-block, due to its unique two-piece design can be worn full time and thus have shorter treatment time. Interceptive treatment in Sweden In Sweden all dental treatment up to 19 years of age is fully subsidized by the government. Interceptive orthodontic treatment is included. Prior to interceptive orthodontic treatment it is common for the GDPs to have clinical consultations with orthodontists. The GDPs initiate by selecting patients to these consultations. From the assessment of orthodontic treatment need orthodontists decide which children to be offered treatment. Less complex cases are in many counties treated by the responsible GDP, whereas comprehensive treatment is referred to the specialist clinic. The choice of interceptive method varies in different parts of Sweden. Generally, the most common used appliances in general dental clinics in Sweden are quad-helix or removable appliances to correct cross bites and functional appliances to correct Class II relations (Josefsson & Halling 2000, Follin et al. 1993, Follin & Milleding 1994). Unanimous usage of index of treatment need in Sweden does not currently exist. Different counties have their choice of index. The most often used indexes in Sweden are that of the Swedish National Board of Health and Welfare and the index of 13 orthodontic treatment need (IOTN) which was originally developed by Brook and Shaw (1989) (SBU). Similar to the view in the rest of the Nordic countries, the Swedish public orthodontic care is in favour of early treatment to correct unfavourable growth and trauma prevention in order to reduce further treatment need and thus costs. The extension of prescribed interceptive treatment performed by GDPs is usually determined by regional orthodontists but also based on the GDP’s knowledge and interest. There is no national standard for prescribing interceptive treatment to GDPs. Prevalence of orthodontic consultation and orthodontic treatment in Sweden has been studied by several authors, see Table 3a-b. Table 3a shows that it is rather common with orthodontic consultations, approximately half of the children had at some occasion orthodontic consultation. The prevalence of received orthodontic treatment decreased to approximately forty percent (Table 3b). Table 3a. Prevalence of received orthodontic consultation in different counties in Sweden. Authors Received orthodontic Age (yrs) County consultation (%) Bergstrom et al. 1996 55 19, n=942 KronA SthlmB KoppC Karlander & Kurol 2003, 48 19, n=223 Östergötland Permert et al. 1998 Lagerstrom et al. 2000 46 19, n=1,554 Halland A Kronoberg, BStockholm, CKopparberg Table 3b. Prevalence of received orthodontic treatment in different counties in Sweden. Authors Received orthodontic Age (yrs) County treatment (%) Bergstrom et al. 1996 37 19, n=942 KronA SthlmB KoppC Karlander & Kurol 2003, 44 19, n=223 Östergötland Permert et al. 1998 Mohlin et al. 2002 36 12, n=263 Bohuslän A Kronoberg, BStockholm, CKopparberg 14 Interceptive treatment in Uppsala County Regarding interceptive orthodontic treatments in general, there are different treatment concepts concerning where the treatment should be carried out, at a general dental clinic or at a specialist clinic. Uppsala County has two regions with two specialist clinics. Region 1 is a large urban area whose specialist clinic is responsible for the orthodontic care of many clinics nearby and a few rural clinics. Region 2 is a small urban area and has less orthodontic resources than Region 1 and provides care for only a few clinics. Both specialist clinics are strategically located and are as well situated next to a general dental clinic. The general dental clinics can additionally be sorted in urban and rural clinics depending on proximity to the specialist clinic. The general dental clinics located farther than 15 km from the specialist clinic are defined as rural. The two regions in Uppsala County are practising different treatment approaches. In Region 1 most of the interceptive treatments are routinely performed by GDPs. In Region 2 nearly all interceptive treatment is carried out at the specialist clinic with aid from orthodontic assistants. No previous evaluation that especially focuses on the overall interceptive treatment in Sweden can be found in the literature. The total percentage of initiated both interceptive and comprehensive orthodontic treatment with appliances in Uppsala County in 2004 in each age group was 24 percent (SBU). The extension of given interceptive treatment has not been recorded earlier, nor the treatment provider, general dentists or specialists. This knowledge can be useful when planning for orthodontic resources. For example educating GDPs in interceptive orthodontics may need to be improved as demand increases for such treatments. The significance of the location of the general dental clinics in urban and rural areas with respect to proximity to the specialist clinic 15 regarding orthodontic treatment has neither been investigated earlier in Sweden. This knowledge can show if there exists the same chances for children in urban and rural clinics to receive orthodontic treatment. The guideline for GDPs in Uppsala County in selecting patients and for orthodontists when deciding which patients to give treatment is a modified variant of the IOTN. Thus, the decision to show a patient for an orthodontist lies entirely on the GDP. Therefore, it is paramount that GDPs are well educated in the IOTN. Aims The aims of this study are to: • evaluate the documentation of received interceptive orthodontic treatment by the General Dental Practitioners in a randomly selected child cohort in the Public Dental Service in Uppsala County • show the distribution of orthodontic treatment provided by General Dental Practitioners in urban and rural areas • present the given treatments for interception provided by the General Dental Practitioners in the Public Dental Service in Uppsala County 16 Materials and Methods The design of this study was a descriptive retrospective cohort study. This study was carried out at thirteen PDS clinics in Uppsala County, the 4th largest province in Sweden with a population of about 300,000. Average number of children per age group is about 3,000 (SCB). Percentage of each age group with a private dental caretaker is estimated to 8.5 percent. These children were excluded from the study population since their records cannot be found in the PDS clinics. The patients came from both urban and rural areas. Records from patients, born in 1989 on the 1st, 5th, 10th, 15th, 20th and 25th in every month, were systematically selected. This generated a total of 653 records, 37 of them had incomplete records and were excluded. Thus, this study consisted of the documentation of 616 records. The records were examined for data from 3 years of age in 1992 until 16 years of age in 2005, retrospectively. By the age of 16 all of the interceptive treatment had been terminated. All data were collected by the same examiner to rule out any variation error during collecting process. Data from both paper records and digital records (since 2002/2003) were included. The sex distribution was even, 321 (52%) boys and 295 (48%) girls. The inclusion criterion was complete records during this period (3-16yrs of age). The exclusion criterion was incomplete records. Data from each record was obtained by using a standardized protocol, see Appendix. The following categories were searched and recorded; gender, orthodontic diagnosis, orthodontic consultation, given treatment, treatment provider and if possible treatment results and need of further treatment. A patient could have been given more than one treatment. Orthodontic consultation could result in one of the following; non treatment 17 (low treatment need and patients who declined), treatment by a GDP or treatment by an orthodontist. For this study, ethical consent has been obtained and approved by the Swedish Regional Ethical Review Board in Stockholm (protocol number 2006/5:11). Statistics A sample size calculation for proportion (Wayne 2005) was carried out on the basis that earlier studies have shown that the prevalence of received orthodontic consultations would be about 45 percent (Table 3a). For a confidence interval of 5 percent and 99 percent confidence level the calculation suggests a total sample size of 539 records. Binomial test (Abdi 2007) was used to test if there were any significant differences between girls and boys in the no treatment group, GDP treated group and orthodontist treated group. The null hypothesis was that there is no difference between boys and girls in the groups. A significance level lower than 0.05 is accepted. Binomial test was used to compare differences between Region 1 and 2. The null hypothesis here was that there is no difference in distribution of orthodontic providers. 18 Results Distribution of patients selected and sorted for orthodontic treatment with respect to proximity to respective specialist clinic for both regions is shown in Fig. 1 and for Region 1 and 2 separately, is shown in Fig. 2 and 3. In this study, the records revealed that almost half of the children had at some occasion orthodontic consultation and subsequently about one third received either interceptive or comprehensive treatment (Fig. 1-3). It should be noted that a few children received interceptive treatment without any orthodontic consultation and also a few children referred to the specialist clinic resulted in no treatment (Fig. 1). Most of the patients selected for consultation received one or two orthodontic consultations (range 1-6). No significant differences were found between boys and girls either in the non treatment group, the GDP treated group or the orthodontist treated group, thus the null hypothesis is accepted. In Region 2 more interceptive treatment was performed at the specialist clinic compared to at the specialist clinic in Region 1 (Fig. 2 and 3) (p<0.01). Consequently, in Region 2 in the urban clinic, proportionally less interceptive treatment was carried out by GDPs compared to the urban clinics in Region 1 (Fig. 2 and 3) (p=0.25). In Region 1 and 2 the rural clinics did together proportionally more interceptive treatment compared to the urban clinics in Region 1 and 2 together (Fig. 2 and 3) (p<0.05). As for comprehensive treatment there was a tendency of a more generous attitude of providing treatments to urban clinics in both regions (Fig. 2 and 3) (p<0.05). This is in line with the different treatment concepts in the two regions in Uppsala County regarding if interceptive treatment should be carried out at specialist clinics or at 19 general dental clinics. As a result, Region 1 and 2 show different distribution of orthodontic providers and orthodontic treatment, thus the null hypothesis is rejected. Of the patients who had consultations and ended up in the non treatment group, 14 (18%) were offered treatment but declined and 62 (82%) were assessed as having too low treatment need to be offered fully subsidized orthodontic treatment by the PDS (Fig. 1). Of the patients who received treatment by GDPs, 81 (74%) (Region 1 (64/89) and Region 2 (17/20)) had completed treatment as noted in the records, 14 (13%) (Region 1 (10/109) and Region 2 (4/109)) were in further treatment need and referred to the specialist clinic and 14 (13%) had treatments which were discontinued prematurely. The frequencies of different treatment methods used by GDPs after orthodontic consultation in Region 1 and 2 are presented in Table 4. Table 4 shows that proportionally more functional appliances were used in Region 1 compared to Region 2. In the present study, percentage of received interceptive and comprehensive orthodontic treatment with appliances was 30% (186/616) and without appliances 6% (40/616). 20 Total sample population n=616 (100%) Region 1 n=506 Region 2 n=110 General dental practitioners select 48% (298) for orthodontic consultation 12% (76) 20% (126) 15% (96) Non treatment 2% (13)* Interceptive treatment at General dental clinics by GDPs 2% (14)** Referrals to Specialist clinic 1% (9) Interceptive treatment by orthodontists 3% (21) Comprehensive treatment by orthodontists 18% (110) Figure 1. Orthodontic treatment flow in Region 1 and 2. The General dental practitioners (GDPs) first select patients for consultation, then the orthodontists sort them into different groups. Numbers of individuals are shown within parenthesis. Due to round up the given percentage may not add up evenly. * Treatments by GDPs without orthodontic consultation. ** Further treatment need, referrals to specialist clinic. 21 Region 1 n=506 (100%) Urban clinics n=343 Rural clinics n=163 General dental practitioners (GDPs) select 46% (235) for orthodontic consultation 11% (56) 20% (100) 16% (79) Non treatment 2% (10)* Interceptive treatment at General dental clinics by GDPs 3% (14)** Referrals to Specialist clinic 2% (9) Interceptive by GDPs Urban Clinics 9% (45) [13%] Rural clinics 6% (30) [18%] Interceptive by orthodontists Comprehensive by orthodontists Urban clinics 1% (6) [2%] 14% (70) [20%] Rural clinics 1% (4) [2%] 5% (25) [15%] Figure 2. Orthodontic treatment flow in Region 1. The General dental practitioners (GDPs) first select patients for consultation, then the orthodontists sort them into different groups. Numbers of individuals are shown within parenthesis. Percentage of individuals in proportion to population of urban respective rural clinics is shown within boxed brackets. Due to round up the given percentage may not add up evenly. * Treatments by GDPs without orthodontic consultation. ** Further treatment need, referrals to specialist clinic. 22 Region 2 n=110 (100%) Urban clinic n=55 Rural clinic n=55 General dental practitioners select 57% (63) for orthodontic consultation 18% (20) 24% (26) 15% (17) Non treatment Interceptive by GDPs 3% (3)* Interceptive treatment at General dental clinics by GDPs Urban Clinic 5% (5) [9%] Rural clinic 14% (15) [27%] Referrals to Specialist clinic Interceptive by orthodontists Comprehensive by orthodontists Urban clinic 7% (8) [15%] 10% (11) [20%] Rural clinic 3% (3) [5%] 4% (4) [7%] Figure 3. Orthodontic treatment flow in Region 2. The General dental practitioners (GDPs) first select patients for consultation, then the orthodontists sort them into different groups. Numbers of individuals are shown within parenthesis. Percentage of individuals in proportion to population of urban respective rural clinic is shown within boxed brackets. Due to round up the given percentage may not add up evenly. * Treatments by GDPs without orthodontic consultation. 23 Table 4. Frequencies of treatment methods used by general dental practitioners after orthodontic consultation in Region 1 and 2. Number of respective method is shown within parenthesis. Due to round up the given percentages may not add up evenly. Region 1 n=79 Region 2 n=17 Treatment methods by GDPs after orthodontic consultation With appliances Functional appliances Removable appliances Quad helix Fixed lingual appliances % 64 24 16 14 9 (50) (19) (13) (11) (7) % 35 6 12 6 12 (6) (1) (2) (1) (2) Without appliances Extractions Spatula biting Grinding 37 27 6 4 (29) (21) (5) (3) 65 47 6 12 (11) (8) (1) (2) 24 Discussion The prevalence of orthodontic consultations (48%) and received both interceptive and/or comprehensive orthodontic treatment (37%) in this study are similar to the findings of other counties in Sweden (Table 3a-b). The economic resources of the PDS in most counties in Sweden restrict orthodontists from performing routine screening of all children. A system where GDPs select patients for orthodontic consultation, like in most counties in Sweden, can therefore give, as this study shows, a considerably high chance to detect malocclusions and subsequently receive orthodontic treatment. However, this system requires that the examinations are done by competent dental personnel. This is not always the case. The consequences can for example lead to missed ectopic upper permanent canines or result in showing too many low treatment need patients, which both substantially consume resources. Nearly all interceptive treatments in Uppsala County are preceded by orthodontic consultations as very few patients received treatment without any consultation (Fig. 1). This shows that the system previously discussed, in that aspect, is extensively followed. The results concerning differences in distribution of orthodontic treatment and provider in this study can be explained by the different treatment concepts in Region 1 and 2. This study showed that these two concepts resulted in different treatment providers. Region 1 distributes the interceptive treatment to the general dental clinics and Region 2 performs most of the treatment in the specialist clinic. Both concepts are, however, dependent on the orthodontic consultations in order to detect malocclusions. The advantages of providing interceptive orthodontic treatment at a general dental clinic may be the shorter distance to the clinic and thus less time spent on travels. Also, for this concept to be successful the treatments require competent providers with sufficient 25 supervision by orthodontists. Interceptive treatment at a specialist clinic is often considered more effective and with shorter treatment time. Since the treatment at a specialist clinic is performed with aid from orthodontic assistants it may also be regarded as consuming less dentist/orthodontist resources. Future investigation of the cost-effectiveness of these two concepts seems justified. As a malocclusion can often be treated by more than one approach, orthodontists have different ways of reaching the same result. An example is treatment of large over jets. In Region 2 the urban general dental clinic had proportionally fewer GDP treatments compared to the urban clinics in Region 1. However, a binomial test could not show a significant difference (p=0.25), mainly due to large discrepancies in population sizes of Region 1 and 2. In spite of that, the difference can partially be explained by that the regional orthodontists in Region 2 often used fixed appliances for early reduction of over jets and deep bites in Class II cases whereas the orthodontists in Region 1 preferred functional appliances for the same malocclusions provided by GDPs. It was thus shown that functional appliances are more commonly used in Region 1 than in Region 2. Since the use of fixed appliance is not suitable for GDPs, this may answer for the low number of treatments by GDPs in Region 2, especially in the urban clinic. It was also shown that proportionally more interceptive treatment by GDPs was performed in rural clinics compared to urban clinics in both regions (p<0.05). This might imply that rural clinics take more responsibility for the orthodontic care because of the long distance to the nearest specialist clinic. The patients, who received interceptive treatment by GDPs but had a further need of treatment, did not always imply that the treatments by GDPs were unsuccessful, the 26 patients might have another separate malocclusion which needed further attention and they therefore were referred to a specialist clinic. It should be noted that the patients who were offered treatment and declined, often needed comprehensive treatment usually involving extractions and treatment with fixed appliances at a specialist clinic. Patients from the urban clinics in both regions received significantly more comprehensive orthodontic treatment compared to patients from the rural clinics. The reason for this is difficult to explain. It might be the same as for the interceptive treatment; the proximity to the specialist clinic or that children living in a city see more orthodontically treated peers and demand treatment more often. Eighty percent of the non treatment group were considered having too low treatment need. This might suggest that GDPs selected too many patients with low treatment need due to uncertainty of treatment need or pressure from the parents’ side. It is also likely that a malocclusion at the first consultation might have improved until to the second consultation so that treatment was no longer indicated. On the other hand the patients might have been selected too early which usually resulted in no treatment or a new consultation at a more appropriate age. This is obviously resource-demanding. However, on average, seven out of ten patients selected for orthodontic consultation by GDPs did in fact receive treatment. Nevertheless, the GDPs selecting orthodontic patients should be well educated in treatment need selection or more active in consulting more experienced colleagues. Apart from treatment need selection, the education should focus more on appropriate treatment timing. In the present study, 74 percent of the patients who received treatment by GDPs had completed treatment as noted in the records. This must be considered as a high rate. One 27 reason might be that in especially larger clinics, there is usually a GDP with a special interest in orthodontics that takes care of the consultations and subsequent treatments. Sufficient supervision by orthodontists may also have contributed to the results. In Sweden, it has been shown that sufficient orthodontic resources are positively correlated to outcome quality (Bergstrom & Halling 1996). The reasons for drop-outs or prematurely interrupted treatment by GDPs were inadequately recorded. Therefore no conclusions could be made regarding the cause for drop-outs. It is likely that difficulties in co-operation, poor motivation and lack of support at home have contributed to these drop-outs (Roberts et al. 1994). The figures in the present study on interceptive and comprehensive treatment with appliances and without appliances are similar to results from Bergstrom and Halling (1996) who studied the orthodontic care in three Swedish counties. It should be emphasized that the results from this study are entirely dependent on data from the written records. Therefore, it is obvious that especially quality results need to be interpreted with caution. Conclusions This study described the interceptive treatment and selection process in Uppsala County and showed that: • Due to different treatment concepts between the two regional specialist clinics, the general dental clinics showed different distribution of orthodontic providers and orthodontic treatment. The different distribution was also depending on proximity to respective specialist clinic. 28 • Almost half of the children had at some occasion orthodontic consultation, which implies that there is a high chance to detect malocclusions. • About seventy percent of the patients selected for orthodontic consultation received some kind of treatment. This suggests that the GDPs’ orthodontic assessments might have benefited from repeated education in orthodontic treatment need and that it is important with continuous education to further reduce showing low treatment need patients. • Eighteen percent received interceptive treatment by general dental practitioners. In both regions extraction without any appliance was the most often performed treatment. For the studied period, there seemed to be sufficient orthodontic supervision as a high completion rate was recorded. • Compared to other counties in Sweden, Uppsala County showed similar values in treatment with appliances and lower values for treatment without appliances, and the distribution of orthodontic providers was also similar. Acknowledgements I am grateful to Lena Berglund-Stevenberg for her kindness, enthusiasm and infinite help throughout this study. Eva Hellsing for her invaluable advice regarding writing. Siwachoat Srisuttiyakorn for his statistical support. To my family for their understanding and tremendous support. This study was supported by grants from Uppsala County Council. 29 Appendix Protocol For collecting data Excluded: Sex: Clinic: Personal number: Orthodontic diagnosis Sagittal: Vertical: Transversal: Other: Crowding, missing, supplemental, ectopic eruption, asymmetry No consultation Treatment by GDPs Consultation Non treatment Method Completion Treatment by GDPs Treatment by orthodontist Discontinued Referral to orthodontist Treatment method Outcome Completion 30 References Abdi H. Binomial Distribution: Binomial and Sign Tests. In: Salkind NJ, editor. Encyclopaedia of Measurement and Statistics. Thousand Oaks: Sage 2007;89-90. Al Nimri K, Richardson A. Interceptive orthodontics in the real world of community dentistry. Int J Paediatr Dent 2000;10:99-108. Andrup L, Ekblom K, Mohlin B. Orthodontics in 12-year-olds. Tandläkartidningen 1999;91:29-35. [Swedish] Bass NM. Interceptive orthodontics. Keynote address. Eur Orthodont Soc Conf 1996 Abstract p.10. Bassler-Zeltmann S, Kretschmer I, Goz G. Malocclusion and the need for orthodontic treatment in 9-year-old children. Survey based on the Swedish National Board of Health and Welfare Scale. J Orofac Orthop 1998;59:193-201. Bassler-Zeltmann S, Kretschmer I, Goz G. Malocclusion and the need for orthodontic treatment in 9-year-old children. Survey based on the Swedish National Board of Health and Welfare Scale. J Orofac Orthop 1998;59:193-201. Bergstrom K, Halling A. Orthodontic treatment outcome in three Swedish counties with different orthodontic resources. Swed Dent J 1996;20:51-60. Borssen E, Holm AK. Traumatic dental injuries in a cohort of 16-year-olds in northern Sweden. Endod Dent Traumatol 1997;13:276-80. 31 Brook PH, Shaw WC. The development of an index of orthodontic treatment priority. Eur J Orthod 1989;11:309-20. Burden DJ. An investigation of the association between overjet size, lip coverage and traumatic injury to maxillary incisors. Eur J Orthod 1995;17:513-7. Castaner-Peiro A. Interceptive orthodontics: The need for early diagnosis and treatment of posterior crossbites. Med Oral Patol Oral Cir Bucal 2006;11:E210-4. Corruccini RS, Flander LB, Kaul SS. Mouth breathing, occlusion and modernization in a north Indian population. An epidemiologic study. Angle Orthod 1985;55:190-6. Cura N, Sarac M. The effect of treatment with the Bass appliance on skeletal Class II malocclusions: a cephalometric investigation. Eur J Orthod 1997;19:691-702. Davidovitch M, McInnis D, Lindauer SJ. The effects of lip bumper therapy in the mixed dentition. Am J Orthod Dentofacial Orthop 1997;111:52-8. Dyer FM, McKeown HF, Sandler PJ. The modified twin block appliance in the treatment of Class II division 2 malocclusions. J Orthod 2001;28:271-80. Review. Egermark-Eriksson I, Carlsson GE, Magnusson T, Thilander B. A longitudinal study on malocclusion in relation to signs and symptoms of cranio-mandibular disorders in children and adolescents. Eur J Orthod 1990;12:399-407. Follin ME, Kahnberg E, Sjostrom O. Assessing the costs of activator treatments in general practice. Br J Orthod 1993;20:235-40. 32 Follin ME, Milleding A. Quad-helix treatment in general practice. A retrospective study of failures of appliance and estimation of costs. Swed Dent J 1994;18:43-8. Forsberg CM, Tedestam G. Etiological and predisposing factors related trauma injuries to the permanent teeth. Swed Dent J 1993;17:183-90. Gerety RG. Non-extraction treatment: utilization of the lip bumper to establish the mandibular arch. J Gen Orthod 1997;8:6-12. Ghafari J, Shofer FS, Jacobsen-Hunt U, Markowitz DL, Laster LL. Headgear versus functional regulator in the early treatment of Class II, Division 1 malocclusion. Am J Orthod Dentofacial Orthop 1998;113:51-61. Hannuksela A. The prevalence of Malocclusion and the Need for Orthodontic Treatment in 9-year-old Finnish School children. Proc Finn Dent Soc 1977;73:21-26. Heikinheimo K, Salmi K. Need for orthodontic intervention in five-year-old Finnish children. Proc Finn Dent Soc 1987;83:165-9. Heikinheimo K. Need of orthodontic treatmen in 7-year-old Finnish children. Community Dent Oral Epidemiol 1978;6:129-34. Helm S. Prevalence of malocclusion in relation to development of the dentition. An epidemiological study of Danish schoolchildren. Acta Odontol Scand 1970;:Suppl 58:1+ 33 Hosseini KR, Dahlstrom M, Huggare J. Malocclusion and the need for orthodontic treatment in 9-year-old immigrant children in Stockholm, Sweden. Swed Dent J 1999;23:209-16. Illing HM, Morris DO, Lee RT. A prospective evaluation of Bass, Bionator and Twin Block appliances. Part I-The hard tissues. Eur J Orthod 1998;20:501-16. Jacobs T, Sawaengkit P. National Institute of Dental and Craniofacial Research efficacy trials of bionator class II treatment: a review. Angle Orthod 2002;72:571-5. Jarvinen S. Incisal overjet and traumatic injuries to upper permanent incisors. A retrospective study. Acta Odontol Scand 1979;37:335-8. Jena AK, Duggal R, Parkash H. Skeletal and dentoalveolar effects of Twin-block and bionator appliances in the treatment of Class II malocclusion: a comparative study. Am J Orthod Dentofacial Orthop 2006;130:594-602. Josefsson E, Halling A. Influence of economic restraints and reduced specialist resources on delivery and quality of orthodontic care. Swed Dent J 2000;24:165-72. Karaiskos N, Wiltshire WA, Odlum O, Brothwell D, Hassard TH. Preventive and interceptive orthodontic treatment needs of an inner-city group of 6- and 9-year-old Canadian children. J Can Dent Assoc 2005;71:649. Karlander EL, Kurol J. Outcome of orthodontic care in 19-year-olds attending the Public Dental Service in Sweden: Residual need and demand for treatment. Swed Dent J 2003;27:91-97. 34 Kau CH, Durning P, Richmond S, Miotti FA, Harzer W. Extractions as a form of interception in the developing dentition: a randomized controlled trial. J Orthod 2004;31:107-114. Kennedy DB, Osepchook M. Unilateral posterior crossbite with mandibular shift: a review. J Can Dent Assoc 2005;71:569-73. Kerr WJ, McCall JH, Frostick J. The use of removable orthodontic appliances in the General Dental Service. Br Dent J 1996;181:18-22. Keski-Nisula K, Lehto R, Lusa V, Keski-Nisula L, Varrela J. Occurrence of malocclusion and need of orthodontic treatment in early mixed dentition. Am J Orthod Dentofacial Orthop 2003;124:631-8. Kurol J, Berglund L. Longitudinal study and cost-benefit analysis of the effect of early treatment of posterior cross-bites in the primary dentition. Eur J Orthod 1992;14:173-9. Kutin GG, Hawes RR. Posterior cross-bites in the deciduous and mixed dentitions. Am J Orthod 1969;56:491-504. Lagerstrom L, Stenvik A, Espeland L, Hallgren A. Outcome of a scheme for orthodontic care: a comparison of untreated and treated 19-year-olds. Swed Dent J 2000;24:49-51. Larsson E. Dummy and finger-sucking habits in 4-year-olds. Swe Dent J 1975;68:219224. 35 Larsson E. Effect of dummy-sucking on the prevalence of posterior cross-bite in the permanent dentition. Swed Dent J 1986;10:97-101. Linder-Aronson S, Bjerrehorn K, Forsberg CM. Objective and subjective need for orthodontic treatment in Stockholm County. Swed Dent J 2002;26:31-40. Lindner A. Longitudinal study of the effect of early interceptive treatment techniques for posterior crossbite in the mixed dentition. Scand J Dent Res 1989;97:190-194. Little RM, Riedel RA, Engst ED. Serial extraction of first premolars - postretention evaluation of stability and relapse. Angle Orthod 1990;60:255-62. Maj G, Alleva F, Lucchese FP. Changes in length and width of the mandibular arch from the mixed dentition to completion of the permanent denition. Eur J Orthod 1979;1:259-63. Mohlin B, al-Saadi E, Andrup L, Ekblom K. Orthodontics in 12-year old children. Demand, treatment motivating factors and treatment decisions. Swed Dent J 2002;26:89-98. Mugonzibwa EA, Kuijpers-Jagtman AM, van 't Hof MA, Kikwilu EN. Need for orthodontic treatment among Tanzanian children. East Afr Med J 2004;81:10-5. Murphy CC, Magness WB, English JD, Frazier-Bowers SA, Salas AM. A longitudinal study of incremental expansion using a mandibular lip bumper. Angle Orthod 2003;73:396-400. 36 Nerder PH, Bakke M, Solow B. The functional shift of the mandible in unilateral posterior crossbite and the adaptation of the temporomandibular joints: a pilot study. Eur J Orthod 1999;21:155-166. Northaway WM, Wainright RL, Demirjian A. Effects of premature loss of deciduous molars. Angle Orthod 1984;54:295-329. O’Brien K. Is the early treatment for Class II malocclusion effective? Results from a randomized clinical trial. Am J Orthod Dentofacial Orthop 2006;129:S64-5. O’Brien, Wright J, Conboy F, Sanjie Y, Mandall N, Chadwich S, et al. Effectivenes of early orthodontic treatment with the Twin-block appliance: a multicenter, randomized clinical trial. Part 1: Dental and skeletal effects. Am J Orthod Dentofacial Orthop 2003;124:234-43. O’Brien K, Wright J, Conboy F, Sanjie Y, Mandall N, Chadwick S, Connolly I, Cook P, Birnie D et al. Effectiveness of treatment for Class II malocclusion with the Herbst or twin-block appliances: a randomized, controlled trial. Am J Orthod Dentofacial Orthop 2003;124:128-37. Onyeaso CO. Need for preventive/interceptive orthodontic treatment among 7-10-yearold children in Ibadan, Nigeria: an epidemiological survey. Odontostomatol Trop 2004;27:15-19. Osborn WS, Nanda RS, Currier GF. Mandibular arch perimeter changes with lip bumper treatment. Am J Orthod Dentofacial Orthop 1991;99:527-532. 37 Pancherz H. The effects, limitations, and long-term dentofacial adaptations to treatment with the Herbst appliance. Semin Orthod 1997:3;232-43. Review. Permert L, Karlander EL, Wilhelm E. Treatment of malocclusion in children and adolescents at a Public Dental Service clinic in Sweden: extent and cost. Swed Dent J 1998;22:187-193. Petren S, Bondemark L, Soderfeldt B. A systematic review concerning early orthodontic treatment of unilateral posterior crossbite. Angle Orthod 2003;73:588-596. Petti S, Cairella G, Tarsitani G. Childhood obesity: a risk factor for traumatic injuries to anterior teeth. Endod Dent Traumatol 1997;13:285-8. Petti S, Tarsitani G. Traumatic injuries to anterior teeth in Italian schoolchildren: prevalence and risk factors. Endod Dent Traumatol 1996;12:294-7. Pirttiniemi PM. Association of mandibular and facial asymmetries – a review. Am J Orthod Dentofacial Orthop 1994;106:191-200. Popovich F, Thompson GW. Evaluation of preventive and interceptive orthodontic treatment between three and eighteen years of age. Trans Third Int Orthodont Cong 1973:260-281 Proffit WR, Fields HW Jr, Ackerman JL. Contemporary orthodontics, 3rd edition. St Louis: Mosby 2000;422-7. Richardson A. Interception defined. In: Interceptive orthodontics. London: British Dental Association 1999;1-4. 38 Richardson ME. The relationship between the amount space present in the deciduous dental arch and the rate and degree of space closure subsequent to the extraction of a deciduous molar. Trans Br Soc Study Orthod 1965;16:111-8. Rizell S, Svensson B, Tengstrom C, Kjellberg H. Functional appliance treatment outcome and need for additional orthodontic treatment with fixed appliance. Swed Dent J 2006;30:61-8. Roberts EE, Kassab JY, Sandham JS, Willmot DR. Non-completion of active orthodontic treatment. Br J Orthod 1994;21:275-8. Ronnerman A. The effect of early loss of primary molars on tooth eruption and space conditions. A longitudinal study. Acta Odontol Scand 1977;35:229-39. SBU: The Swedish Council on Technology Assessment in Health Care: Bettavvikelser och tandreglering i ett hälsoperspektiv. [Swedish] SCB. Statistics Sweden. Statistiska centralbyrån. Befolkningsstatistik. Uppsala. [Swedish] Schopf P. Indication for and frequency of early orthodontic or interceptive measures. J Orofac Orthop 2003;64:186-200. Singh GD, Thind BS. Effects of the headgear-activator Teuscher appliance in the treatment of Class II Division 1 malocclusion: a geometric morphometric study. Orthod Craniofac Res 2003;6:88-95. 39 Solomon MJ, English JD, Magness WB, McKee CJ. Long-term stability of lip bumper therapy followed by fixed appliances. Angle Orthod 2006;76:36-42. Stahl F, Grabowski R. Orthodontic findings in the deciduous and early mixed dentition – Interferences for a preventive strategy. J Orofac Orthop 2003;64:401-16. Tausche E, Luck O, Harzer W. Prevalence of malocclusions in the early mixed dentition and orthodontic treatment need. Eur J Orthod 2004;26:237-44. Terlaje RD, Donly KJ. Treatment planning for space maintenance in the primary and mixed dentition. ASDC J Dent Child 2001;68:109-114. Thilander B, Myrberg N. The prevalence of malocclusion in Swedish school children. Scand J Dent Res 1973;81:12-21. Thilander B, Pena L, Infante C, Stella Parada S, de Mayorga C. Prevalence of malocclusion and orthodontic treatment need in children and adolescents in Bogota, Colombia. An epidemiological study related to different stages of dental development. Eur J Orthod 2001;23:153-67. Thilander B, Rubio G, Pena L, de Mayorga C. Prevalence of temporomandibular dysfunction and its association with malocclusion in children and adolescents: an epidemiologic study related to specified stages of dental development. Angle Orthod 2002;72:146-54. Thilander B, Wahlund S, Lennartsson B. The effect of early interceptive treatment in children with posterior cross-bite. Eur J Orthod 1984;6:25-34. 40 Tsarapatsani P, Tullberg M, Lindner A, Huggare J. Longterm follow-up of early treatment of unilateral forced cross-bites. Orofacial status. Acta Odontol Scand 1999;57:97-104. Tschill P, Bacon W, Sonko A. Malocclusion in the deciduous dentition of Caucasian children. Eur J Orthod 1997;19:361-7. Tulloch JF, Proffit WR, Phillips C. Outcomes in a 2-phase randomized clinical trial of early Class II treatment. Am J Orthod Dentofacial Orthop 2004;125:657-67. Vakiparta MK, Kerosuo HM, Nystrom ME, Heikinheimo KA. Orthodontic treatment need from eight to 12 years of age in an early treatment oriented public health care system: a prospective study. Angle Orthod 2005;75:344-9. Wayne WD. Estimation. In: Biostatistics: A foundation for analysis in the health sciences. 8th ed. New York: John Wiley & Sons, Inc. 2005;189. Werner WP, Shivapuja PK, Harris EF. Skeletodental changes in the adolescent accruing from use of the lip bumper. Angle Orthod 1994;64:13-22. Wheeler TT, McGorry SP, Dolce C, Taylor MG, King GJ. Effectiveness of early treatment of Class II malocclusion. Am J Orthod Dentofacial Orthop 2002;121:9-17. Wong ML, Fatimah C, Kheng L, Daud N, Burhanudin R, Gere M. Role of interceptive orthodontics in early mixed dentition. Singapore Dent J 2004;26:10-4. 41