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From: Cortical Effects of Deep Brain StimulationImplications for Pathogenesis and Treatment of Parkinson
Disease
JAMA Neurol. 2014;71(1):100-103. doi:10.1001/jamaneurol.2013.4221
Figure Legend:
Proposed Mechanism of Deep Brain Stimulation (DBS) at the Subthalamic Nucleus (STN) in Rectifying the Pathological Firing of the
Motor CortexAt the top, raster plots of action potentials demonstrate that under parkinsonism, layer V neurons of the motor cortex
exhibit synchronized burst firing that is correlated with the appearance of a pathological β rhythm. Delivery of DBS to the STN
restores the irregular firing pattern as observed in normal individuals. As depicted in the left side of the diagram, the conventional
view holds that DBS of the STN affects downstream
nuclei
theAmerican
STN within
the complex basal ganglia circuit and, finally, the motor
Copyright
© of
2014
Medical
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cortex.
In contrast,5/5/2017
as depicted in the right side of Association.
the diagram,Allrecent
evidence
rights reserved. suggests that direct modification of the neural
activity of layer V neurons by the antidromic activation of corticofugal fibers from the STN desynchronizes the abnormal firing of the
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