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Metachronous testicular tumor of an extragonadal germ cell tumor
Hacker A, Hatzinger M, Knoll T, Michel MS, Kohrmann KU, Alken P, Siegsmund M.
Urologische Universitatsklinik, Klinikum Mannheim gGmbH, Fakultat fur Klinische Medizin
Mannheim der Ruprecht-Karls-Universitat Heidelberg, Mannheim. [email protected] 2003.
INTRODUCTION: Approximately 5 - 7 % of germ cell tumors are of extragonadal origin.
Biology and genetics are unclear, especially when the primary location is in the retroperitoneum.
Chemotherapy is the initial treatment of choice for extragonadal germ cell tumors (EGGCTs),
followed by surgical resection of the residual tumor mass. A primary testicular tumor must be
ruled out by sonographic investigation and biopsy. The rate of metachronous testicular cancer in
men with primary EGGCT is largely unknown. CASE REPORT: We present the first patient in
the literature who developed a metachronous testicular cancer 10 months after primary
occurrence of EGGCT in the retroperitoneum. CONCLUSIONS: This case report emphasizes
the importance of follow-up examinations of patients with primary EGGCTs. They should
include careful sonographic investigation of the testis in order to detect metachronous testicular
cancer early. Suspicious findings require open surgery biopsy. Intraoperative histopathology can
be false-negative for cancer detection, as an immunohistochemical examination is not available.
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