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Transcript 
Glycerolipid metabolism
Glycerol
Glycerone
2.7.1.30
3.1.3.1
CDP-ethanolamine
Glycerol-3P
Glycerone-P
Phosphatidyl-ethanolamine
1.1.1.8
2.3.1.21
2.3.1.-
3.1.1.4
2.7.7.14
Lysophosphatidyl-ethanolamine
1,2-Diacyl-glycerol
Monoacylglycerol
Ethanolamine
Triacylglycerol
3.1.1.3
3.1.1.3
Fatty acid
Fatty acid metabolism
Lsp-1
1.3.3.6
1.3.99.7
1.3.99.3
6.2.1.3
2.3.1.16
Fatp
1.1.1.21
1
Supplementary Figure 1 – Glycerolipid metabolism pathway showing differentially up- (red) and down- (blue) regulated genes (p ≤
10-5). The expression of those genes leads to degradation of triglycerides and subsequent fatty acid catabolism, where all 7 genes being
differentially expressed are up-regulated.
OAT
Urea cycle
(detoxification)
Supplementary Figure 2 – Role of Ornithine Amino Transferase (OAT) enzyme as a switchpoint between
synthesis of the neurotransmitters glutamate and GABA, and stimulation of detoxification through the urea
cycle. GABA biosynthesis feeds back to downregulate OAT activity.
Supplementary Table 1 - Differentially expressed genes for combined analysis of NC and CA populations (amplified RNA) (p < 0.0001)
Up-regulated genes
CG#
GenBank#
fold change
p-value
Gene ID
Process involved
CG1583
AI514673
-1.337
3.92E-49
phospholipase A2 (EC:3.1.1.4)
(glycero and phospho)lipid metabolism, prostaglandin and leukotriene metabolism
CG5966
AI546197
-1.571
8.74E-43
triacylglycerol lipase (EC:3.1.1.3)
glycerolipid metabolism
CG10960
AA567332
-0.564
3.23E-27
glucose transporter
carbohydrate metabolism and transport
CG9127
AA694881
-0.561
6.36E-21
adenosine 2 (ade2)
phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), purine metabolism
CG3036
AI064426
-0.604
1.60E-20
sodium:phosphate symporter
phosphate transport
CG5295
AI455211
-0.499
1.74E-19
-
PLP-dependent transferases domain
CG18466
AI513084
-0.728
2.67E-19
NAD-dependent methylenetetrahydrofolate dehydrogenase (Nmdmc)
carbohydrate, glyoxylate and dicarboxylate metabolism
CG8286
AA941438
-0.283
4.57E-15
protein kinase inhibitor
cytokine and chemokine mediated signaling pathway, defense response
CG8965
AI513118
-0.346
2.05E-14
-
RA domain, signal transduction
CG9707
AI532190
-0.409
2.52E-14
acyl-Coenzyme A oxidase at 57D proximal (Acox57D-p)
palmitoyl-CoA oxidase (EC:1.3.3.-), fatty acid beta-oxidation
CG9126
AI513593
-0.311
3.69E-14
cell adhesion
CG11089
AA438421
-0.604
7.89E-14
Stromal interaction molecule (Stim)
phosphoribosylaminoimidazolecarboxamide formyltransferase
(EC:2.1.2.3)
CG9547
AI517955
-0.449
1.15E-13
glutaryl-CoA dehydrogenase (EC:1.3.99.7)
Tryptophan, fatty acid and acyl-CoA metabolism, hydroxylysine and lysine catabolism
CG10733
AA978511
-0.282
1.88E-13
logjam (loj)
intracellular protein transport, oviposition
CG3590
AI109500
-0.342
3.00E-13
adenylosuccinate lyase (EC:4.3.2.2)
purine base metabolism, alanine and aspartate metabolism
CG4288
AI404321
-0.417
4.26E-13
high affinity inorganic phosphate:sodium symporter
carbohydrate and phosphate transport
CG2848
AI455163
-0.274
6.14E-13
Transportin-Serine/Arginine rich (Trn-SR)
protein binding, nuclear mRNA splicing, via spliceosome
CG4472
AI387590
-0.427
6.46E-13
Imaginal disc growth factor 1 (Idgf1)
cell-cell signaling, imaginal disc development, signal transduction
-
AA802181
-0.421
6.70E-13
-
-
-
AA698028
-0.291
7.01E-13
-
-
CG3775
AI402041
-0.465
9.18E-13
metalloendopeptidase (EC:3.4.24.-), neprilysin
proteolysis and peptidolysis
CG15101
AI106969
-0.625
1.14E-12
Juvenile hormone epoxide hydrolase 1 (Jheh1), (EC:3.3.2.-)
defense response, juvenile hormone catabolism, response to toxin
CG4164
AA950501
-0.245
2.48E-12
heat shock protein
defense response
CG7642
AI109609
-0.271
6.93E-12
rosy (ry), xanthine dehydrogenase (EC:1.1.1.204)
defense response, purine metabolism
CG10849
AI542826
-0.289
1.02E-11
Sc2
Ubiquitin-like domain
CG8258
AI455490
-0.252
1.59E-11
ATPase
chaperone complex
CG30122
AA820756
-0.285
1.68E-11
-
RNA binding
CG4533
AI513212
-0.348
2.36E-11
lethal (2) essential for life (l(2)efl), heat shock protein
defense response
CG10383
AI403848
-0.289
3.00E-11
-
ARM repeat domain
CG3705
AI455353
-0.396
3.46E-11
astray (aay), phosphoserine phosphatase (EC:3.1.3.3)
CG2194
AI062444
-0.280
3.80E-11
Rhythmically expressed gene 3 (Reg-3)
L-serine biosynthesis, axon guidance, peripheral nervous system development
dihydropyrimidine dehydrogenase (EC:1.3.1.2), pyrimidine and beta-alanine
metabolism
CG8345
AI237973
-0.630
3.96E-11
Cyp6w1
xenobiotic response
purine base metabolism, one carbon pool by folate
Supplementary Table 1 (continued)
Up-regulated genes
CG#
GenBank#
fold change
p-value
Gene ID
Process involved
CG1244
AA817226
-0.376
3.98E-11
-
-
CG7332
AI455485
-0.328
4.35E-11
-
calcium-binding domain (EF-hand)
CG5809
AA949224
-0.260
4.59E-11
CaBP1, protein disulfide isomerase (EC:5.3.4.1)
protein modification
CG16807
AA392849
-0.243
5.37E-11
-
zinc-finger domain
CG7400
AI533408
-0.314
5.39E-11
Fatty acid (long chain) transport protein (Fatp)
fatty acid metabolism
CG4916
AI455115
-0.361
5.60E-11
maternal expression at 31B (me31B), ATP-dependent RNA helicase
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
CG32350
AA540569
-0.180
9.58E-11
-
protein transport
CG10550
AI386741
-0.353
1.83E-10
-
-
CG6863
AI258193
-0.245
2.06E-10
tolkin (tok), procollagen C-endopeptidase (EC:3.4.24.19)
dorsal/ventral axis specification, proteolysis and peptidolysis
CG11992
AI513128
-0.249
4.03E-10
Relish (Rel)
transcription factor, defense response
CG8411
AI455354
-0.173
4.72E-10
germ cell-less (gcl)
negative regulation of transcription from Pol III promoter
CG12428
AI543215
-0.241
4.88E-10
carnitine O-octanoyltransferase (EC:2.3.1.137)
CG12262
AA817371
-0.366
4.96E-10
acyl-CoA dehydrogenase (EC:1.3.99.3)
amino acid and glycerolipid metabolism, lysine degradation
fatty acid beta-oxidation, amino acid degradation, beta-alanine and propanoate
metabolism
CG5140
AI063644
-0.548
5.76E-10
-
defense response, signal transduction
CG18239
AA990733
-0.675
7.13E-10
Cyp12d1-d
xenobiotic response
CG17566
AA951884
-0.222
7.42E-10
gammaTub37C
structural constituent of cytoskeleton, tubulin binding
CG10901
AI455566
-0.350
8.15E-10
oskar (osk)
long-term memory
CG14207
AI456979
-0.245
1.17E-09
-
HSP20-like chaperone domain
CG12034
AI455549
-0.247
1.33E-09
sphingomyelin phosphodiesterase (EC:3.1.4.12)
CG9096
AI455310
-0.173
1.69E-09
Cyclin D (CycD), cyclin-dependent protein kinase regulator (EC:2.7.1.-)
sphingophospholipid biosynthesis, intracellular signaling cascade
JAK-STAT cascade, cell growth and/or maintenance, cell proliferation, regulation of
cell cycle
CG4680
AI402134
-0.292
1.93E-09
-
-
CG6385
AI388355
-0.488
2.08E-09
sarcosine dehydrogenase (EC:1.5.99.1)
urea cycle and metabolism of amino groups; glycine, serine and threonine metabolism
CG7001
AI455224
-0.200
2.39E-09
Protein kinase-like 17E (Pk17E)
protein serine/threonine kinase, protein amino acid phosphorylation
CG3821
AI519001
-0.243
2.53E-09
Aspartyl-tRNA synthetase (Aats-asp), (EC:6.1.1.12)
aspartyl-tRNA aminoacylation, alanine and aspartate metabolism
CG5899
AI513103
-0.215
2.76E-09
ATP-dependent DNA helicase
DNA metabolism
CG4193
AI455413
-0.762
3.13E-09
deadhead (dhd), thiol-disulfide exchange intermediate
electron transport, female meiosis, protein folding, sulfur metabolism
CG8772
AI403407
-0.198
3.72E-09
no extended memory (nemy), glutaminase (EC:3.5.1.2)
glutamine, glutamate and nitrogen metabolism, locomotory behavior, memory
CG9986
AA948889
-0.266
3.77E-09
-
-
CG10859
AI238624
-0.304
4.02E-09
-
motor activity, microtubule-based movement
CG7197
AA950998
-0.178
4.40E-09
GTPase
surface receptor linked signal transduction, intracellular protein transport
CG12750
AI533057
-0.210
4.45E-09
-
Middle domain of eIF4G, ARM repeat domains
CG8553
AI514756
-0.213
5.12E-09
selenide,water dikinase (SelD)
cell proliferation, imaginal disc development, selenocysteine biosynthesis
Supplementary Table 1 (continued)
Up-regulated genes
CG#
GenBank#
fold change
p-value
Gene ID
Process involved
CG10248
AI107730
-0.796
5.49E-09
Cyp6a8
steroid metabolism, defense response
CG3570
AI109974
-0.304
1.03E-08
-
S-adenosyl-L-methionine-dependent methyltransferases domain
CG12013
AI544386
-0.257
1.11E-08
PHGPx, glutathione peroxidase (EC:1.11.1.9)
response to lipid hydroperoxide, glutathione metabolism
CG4466
AA803624
-0.532
1.35E-08
defense response, protein refolding
CG2674
AI520331
-0.260
1.82E-08
Heat shock protein 27 (Hsp27)
Minute (2) 21AB (M(2)21AB), methionine adenosyltransferase
(EC:2.5.1.6)
CG7840
AI061954
-0.172
1.90E-08
3-oxo-5-alpha-steroid 4-dehydrogenase (EC:1.3.99.5)
bile acid biosynthesis, androgen and estrogen metabolism
CG11654
AA695242
-0.281
2.21E-08
Adenosylhomocysteinase at 13 (Ahcy13) (EC:3.3.1.1)
purine base metabolism, methionine and selenoamino acid metabolism
CG11284
AI456523
-0.411
2.63E-08
carbonate dehydratase (EC:4.2.1.1)
nitrogen metabolism
CG7530
AI512735
-0.283
3.18E-08
-
-
CG5002
AI519138
-0.220
3.45E-08
high affinity sulfate permease
anion transport, sulfur metabolism
CG33133
AI401966
-0.177
3.47E-08
grauzone (grau)
specific RNA polymerase II transcription factor
CG18769
AA942285
-0.210
3.50E-08
-
-
CG7623
AI532992
-0.151
3.57E-08
slalom (sll), UDP-galactose transporter
3'-phosphoadenosine 5'-phosphosulfate transport
CG8216
AI133872
-0.183
4.05E-08
-
-
CG18445
AI534495
-0.163
4.86E-08
-
-
CG3151
AI406214
-0.178
4.99E-08
Rbp9, RNA binding
regulation of transcription
CG4535
AI515631
-0.191
5.14E-08
FK506-binding protein FKBP59 (FKBP59)
FK506 binding, peptidyl-prolyl cis-trans isomerase, protein folding
CG13397
AI256884
-0.167
5.20E-08
alpha-N-acetylglucosaminidase (EC:3.2.1.50)
protein amino acid glycosylation, glycosaminoglycan degradation
CG3973
AI543495
-0.175
9.00E-08
-
Growth-Arrest-Specific Protein 2 Domain
CG8389
AI532628
-0.226
9.17E-08
monocarboxylate porter
-
CG11842
AI387911
-0.290
9.32E-08
serine-type endopeptidase (EC:3.4.21.-)
proteolysis and peptidolysis
CG5315
AI455386
-0.280
1.10E-07
hormone binding
hormone-mediated signaling, fatty acid oxidation
CG4500
AA949294
-0.530
1.12E-07
long-chain-fatty-acid-CoA ligase (EC:6.2.1.3)
fatty acid metabolism
CG31231
AI109351
-0.460
1.12E-07
-
-
CG15893
AA978768
-0.180
1.17E-07
-
-
CG3057
AI513226
-0.295
1.17E-07
congested-like trachea (colt), carnitine:acyl carnitine carrier
acyl carnitine transport
CG9670
AA941739
-0.130
1.17E-07
falten (fal), GTPase
gastrulation
CG2991
AA264940
-0.193
1.38E-07
-
EGF/Laminin domain
CG3829
AI388223
-0.216
1.42E-07
scavenger receptor
apoptosis, defense response
CG8979
AI513094
-0.149
1.44E-07
proteasome inhibitor
proteolysis
CG8913
AI402263
-0.230
1.63E-07
peroxidase (EC:1.11.1.7)
defense response, phenylalanine and methane metabolism
CG3962
AI109419
-0.191
2.05E-07
Keap1, actin binding
-
one-carbon compound metabolism, methionine and selenoamino acid metabolism
Supplementary Table 1 (continued)
Up-regulated genes
CG#
GenBank#
fold change
p-value
Gene ID
Process involved
CG7668
AA696534
-0.249
2.39E-07
receptor binding
defense response
CG15009
AI534445
-0.307
2.82E-07
Ecdysone-inducible gene L2 (ImpL2)
cell adhesion
CG8552
AA541202
-0.191
2.88E-07
phospholipase A1 (EC:3.1.1.32)
intracellular protein transport, glycerolipid metabolism, phospholipid degradation
CG4180
AA951718
-0.224
3.04E-07
lethal (2) 35Bg (l(2)35Bg)
-
CG5547
AI542374
-0.241
3.19E-07
Phosphoethanolamine cytidylyltransferase (Pect) (EC:2.7.7.14)
Ethanolamine, aminophosphonate and glycerolipid metabolism
CG5174
AI512743
-0.188
3.49E-07
-
-
CG30059
AI532050
-0.283
3.52E-07
N-acetylglucosamine-6-sulfatase (EC:3.1.6.14)
N-acetylglucosamine, carbohydrate, polysaccharide and sulfur metabolism
CG5853
AI533990
-0.247
4.37E-07
ABC transporter
anion and lipid transport
CG8194
AI402129
-0.195
5.58E-07
RNA catabolism
CG4581
AI135472
-0.236
5.73E-07
Ribonuclease X25 (RNaseX25), endoribonuclease
Thiolase, long-chain-3-hydroxyacyl-CoA dehydrogenase
(EC:1.1.1.211)
CG8128
AI063449
-0.210
5.94E-07
CG4600
AA736169
-0.334
6.23E-07
nucleotide phosphatase
yippee interacting protein 2 (yip2), acetyl-CoA C-acyltransferase
(EC:2.3.1.16)
cell proliferation
fatty acid beta-oxidation and biosynthesis, bile acid biosynthesis, amino acid
degradation
CG2155
AI238143
-0.318
6.81E-07
vermilion (v), tryptophan 2,3-dioxygenase (EC:1.13.11.11)
eye pigmentation, ommochrome biosynthesis, tryptophan catabolism
CG3510
AI455345
-0.308
6.89E-07
Cyclin B (CycB), cyclin-dependent protein kinase regulator (EC:2.7.1.-)
mitotic anaphase B
CG13849
AI518994
-0.175
7.12E-07
Nop56, RNA binding
rRNA metabolism
CG8798
AA978416
-0.143
7.47E-07
endopeptidase La (EC:3.4.21.53)
proteolysis and peptidolysis
CG10364
AA951525
-0.239
7.66E-07
msb1l
-
CG8314
AI135792
-0.163
8.00E-07
-
-
CG15825
AA567329
-0.265
8.04E-07
-
-
CG30078
AI403379
-0.197
8.17E-07
protein kinase (EC:2.7.1.37)
signal transduction
CG4107
AI134208
-0.282
8.23E-07
Pcaf, histone acetyltransferase (EC:2.3.1.48)
regulation of transcription from Pol II promoter
CG10537
AI110140
-0.157
8.61E-07
Resistant to dieldrin (Rdl), GABA-A receptor (GABAr)
response to cyclodiene, nerve-nerve synaptic transmission
CG10555
AA539812
-0.180
8.64E-07
-
-
CG10978
AI518543
-0.154
9.12E-07
jagunal (jagn)
microtubule-based movement
-
AI387085
-0.192
1.07E-06
-
-
CG32158
AI543777
-0.174
1.20E-06
adenylate cyclase (EC:4.6.1.1)
G-protein coupled receptor protein signaling pathway, purine metabolism
CG2277
AI455551
-0.156
1.28E-06
nucleotide phosphatase
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
CG4797
AI543335
-0.241
1.29E-06
glucose transporter
carbohydrate metabolism and transport
CG7269
AA820170
-0.167
1.35E-06
Helicase at 25E (Hel25E), pre-mRNA splicing factor
nuclear mRNA splicing, via spliceosome
CG2050
AI455242
-0.212
1.37E-06
modulo (mod), DNA binding
cell proliferation
CG1381
AI515304
-0.144
1.37E-06
nucleic acid binding
protein biosynthesis and metabolism
CG10895
AA949096
-0.238
1.39E-06
loki (lok), protein serine/threonine kinase
cell cycle checkpoint
fatty acid beta-oxidation
Supplementary Table 1 (continued)
Up-regulated genes
CG#
GenBank#
fold change
p-value
Gene ID
Process involved
CG7845
AI515638
-0.141
1.55E-06
-
Trp-Asp repeat (WD-repeat) domain
CG7364
AI063249
-0.162
1.75E-06
transporter
intracellular protein transport
CG8129
AI295161
-0.201
1.94E-06
threonine ammonia-lyase (EC:4.3.1.19)
amino acid metabolism
CG2121
AI402180
-0.240
2.50E-06
-
muscle contraction
CG10206
AA978785
-0.202
2.51E-06
nop5, RNA binding
rRNA processing
CG7777
AA941952
-0.194
2.58E-06
water transporter
cell homeostasis
CG10934
AI405906
-0.307
3.05E-06
-
-
CG9649
AI388374
-0.214
3.10E-06
enteropeptidase (EC:3.4.21.9)
defense response, proteolysis and peptidolysis
CG10565
AA820316
-0.171
3.18E-06
chaperone, unfolded protein binding
protein folding
CG4454
AI456241
-0.187
3.18E-06
-
-
CG1441
AI135852
-0.174
3.52E-06
oxidoreductase (EC:1.-.-.-)
-
CG7935
AI513110
-0.177
3.76E-06
moleskin (msk), protein carrier
epidermal growth factor receptor signaling pathway
CG10419
AI515592
-0.132
3.93E-06
-
-
CG17383
AA979067
-0.140
4.11E-06
-
-
CG5363
AI519205
-0.358
4.14E-06
cdc2, protein binding
G2/M transition of mitotic cell cycle
CG12241
AA951586
-0.127
4.39E-06
GTPase activator
regulation of cell cycle
CG5848
AA391494
-0.178
4.67E-06
cactus (cact), transcription factor binding
defense response
CG2060
AA940642
-0.342
5.03E-06
Cyp4e2
xenobiotic and steroid metabolism
CG10480
AI455275
-0.158
5.42E-06
Bj1 protein (Bj1), Ran guanyl-nucleotide exchange factor
regulation of neurogenesis
CG3009
AI108530
-0.129
5.56E-06
phospholipase A2 (EC:3.1.1.4)
(glycero and phospho)lipid metabolism, prostaglandin and leukotriene metabolism
CG11642
AA948952
-0.164
6.31E-06
-
SRP-dependent cotranslational membrane targeting
CG8975
AI515893
-0.280
6.38E-06
Ribonucleoside diphosphate reductase small subunit (RnrS)
(EC:1.17.4.1), DNA replication, purine and pyrimidine metabolism
CG3835
AI387484
-0.269
6.44E-06
oxidoreductase (EC:1.-.-.-)
carbohydrate metabolism
CG2264
AA950777
-0.142
7.24E-06
cysteine protease inhibitor
proteolysis
CG5605
AI455318
-0.205
7.46E-06
eukaryotic release factor 1 (eRF1), translation release factor
autophagic cell death, translational termination
CG2107
AI531007
-0.155
7.49E-06
carnitine O-palmitoyltransferase (EC:2.3.1.21)
amino acid, fatty acid and glycerolipid metabolism
CG10060
AI455240
-0.136
7.82E-06
G protein alphai subunit 65A (G-ialpha65A), protein binding
G-protein coupled receptor protein signaling pathway
CG5955
AI387868
-0.282
8.03E-06
UDP-glucose 4-epimerase (EC:5.1.3.2)
galactose and nucleotide sugars metabolism
CG3402
AA263203
-0.182
8.15E-06
-
PDZ domain
CG11719
AI109850
-0.141
8.76E-06
Male-specific RNA 98Ca (Mst98Ca)
-
CG4561
AI455095
-0.162
8.90E-06
Tyrosyl-tRNA synthetase (Aats-tyr) (EC:6.1.1.1)
tyrosyl-tRNA aminoacylation
CG31643
AA951625
-0.155
9.28E-06
-
-
Supplementary Table 1 (continued)
Up-regulated genes
CG#
GenBank#
fold change
p-value
Gene ID
Process involved
CG10267
AA941165
-0.136
9.57E-06
transcription regulator
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
CG14882
AI544416
-0.154
1.02E-05
[methionine synthase] reductase (EC:1.16.1.8)
methionine metabolism
CG9193
AI513872
-0.280
1.19E-05
mutagen-sensitive 209 (mus209)
repair of DNA double-strand breaks
CG8782
AI513214
-0.230
1.20E-05
Ornithine aminotransferase precursor (Oat)
ornithine metabolism
CG3423
AA979561
-0.117
1.29E-05
Stromalin (SA), chromatin binding
ectoderm development and neurogenesis
CG9099
AI389634
-0.152
1.34E-05
-
Translation initiation factor SUI1 domain
CG1489
AA941800
-0.165
1.35E-05
Pros45, endopeptidase
proteolysis and peptidolysis
CG2679
AI389732
-0.217
1.41E-05
goliath (gol), transcription regulator
regulation of transcription, DNA-dependent
CG3331
AI404341
-0.137
1.44E-05
ebony (e), beta-alanyl-dopamine synthase
cuticle pigmentation, defense response, dopamine metabolism
CG10444
AI546427
-0.149
1.45E-05
sodium-dependent multivitamin transporter
cation transport, coenzyme and prosthetic group metabolism
CG6695
AI534150
-0.134
1.53E-05
RNA binding
-
CG10578
AI542453
-0.148
1.68E-05
DnaJ-like-1 (DnaJ-1), chaperone
defense response
CG7154
AA817385
-0.202
1.73E-05
-
DNA binding
CG3074
AA802878
-0.174
1.85E-05
cathepsin B (EC:3.4.22.1)
protein metabolism
CG10152
AI134729
-0.130
1.86E-05
beat-IV
IgSF protein related to the Beat axon guidance molecule
CG6680
AI514148
-0.122
1.88E-05
serine-type endopeptidase inhibitor, serpin
apoptosis, proteolysis and peptidolysis
CG10016
AA942527
-0.140
1.97E-05
drumstick (drm)
hindgut morphogenesis
CG9258
AA202260
-0.153
2.01E-05
nervana 1 (nrv1), sodium:potassium-exchanging ATPase (EC:3.6.3.9)
sodium ion transport
CG4875
AI512953
-0.115
2.02E-05
G-protein coupled receptor
signal transduction
CG6523
AI520162
-0.140
2.03E-05
thiol-disulfide exchange intermediate
sulfur metabolism
CG4143
AA694681
-0.171
2.15E-05
multiprotein bridging factor 1 (mbf1), transcription coactivator
central nervous system development
CG10576
AA950591
-0.173
2.21E-05
methionyl aminopeptidase (EC:3.4.11.18)
protein biosynthesis, proteolysis and peptidolysis
CG5938
AI520117
-0.165
2.25E-05
-
-
CG4590
AI455282
-0.146
2.26E-05
inx2, innexin channel
foregut morphogenesis, gap junction
CG4407
AA942491
-0.128
2.28E-05
FMN adenylyltransferase (EC:2.7.7.2)
riboflavin metabolism
CG4287
AI402156
-0.170
2.41E-05
-
-
CG7185
AA941220
-0.179
2.63E-05
RNA binding
mRNA cleavage
CG8449
AA390390
-0.149
2.69E-05
-
Ypt/Rab-GAP domain of gyp1p
CG5595
AI455406
-0.167
2.91E-05
Sex combs extra (Sce), (Ring), protein binding
sex comb development
CG11266
AI455971
-0.126
2.94E-05
pre-mRNA splicing factor
RNA splicing
CG8732
AI294048
-0.239
3.03E-05
l(2)44DEa, acetate-CoA ligase (EC:6.2.1.1)
glycolysis_gluconeogenesis, pyruvate, propanoate and fatty acid metabolism
CG18543
AI546359
-0.203
3.06E-05
matrimony (mtrm)
cell cycle arrest, female meiosis chromosome segregation
Supplementary Table 1 (continued)
Up-regulated genes
CG#
GenBank#
fold change
p-value
Gene ID
Process involved
CG31935
AA941928
-0.177
3.12E-05
-
-
CG2865
AI517147
-0.174
3.24E-05
-
-
CG9022
AA816989
-0.123
3.44E-05
Oligosaccharyltransferase 48kD subunit (Ost48) (EC:2.4.1.119)
N-linked glycosylation
CG7574
AA803601
-0.194
3.59E-05
bip1
-
CG8507
AA952222
-0.148
3.65E-05
-
alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
CG7156
AI455497
-0.188
3.71E-05
protein kinase (EC:2.7.1.37)
signal transduction
CG11589
AA735493
-0.212
3.85E-05
VhaM9.7-1, hydrogen-exporting ATPase (EC:3.6.3.6)
cation transport
CG3385
AA539398
-0.179
3.90E-05
nervy (nvy), transcription factor
regulation of transcription, axon guidance, proto-oncogene
CG8821
AI534944
-0.154
3.96E-05
vismay (vis), transcription factor
regulation of transcription
CG5885
AA246490
-0.210
4.09E-05
-
intracellular protein transport
CG1136
AI517121
-0.115
4.53E-05
-
-
CG11982
AI515261
-0.133
4.60E-05
-
RING finger domain, C3HC4
CG8229
AA948957
-0.099
4.70E-05
-
-
CG11417
AA817592
-0.122
4.74E-05
-
-
CG10009
AI456959
-0.182
4.86E-05
Noa36
nucleolus
CG7556
AI402078
-0.114
4.86E-05
-
Myb DNA binding domain
CG12006
AI546267
-0.131
5.07E-05
transferase (EC:2.-.-.-)
lipid metabolism
CG11115
AI402137
-0.139
5.11E-05
Ssl1, general RNA polymerase II transcription factor
transcription initiation from Pol II promoter
CG7538
AI515560
-0.190
5.13E-05
Minichromosome maintenance 2 (Mcm2), chromatin binding
pre-replicative complex formation and maintenance
CG8785
AI064223
-0.138
5.56E-05
amino acid-polyamine transporter
amino acid transport
CG1064
AI402144
-0.113
5.61E-05
Snf5-related 1 (Snr1), transcription coactivator
positive regulation of transcription, DNA-dependent
CG11403
AA941042
-0.098
6.06E-05
ATP-dependent DNA helicase
nucleotide-excision repair
CG5352
AA439468
-0.152
6.16E-05
Small ribonucleoprotein particle protein B (SmB)
nuclear mRNA splicing, via spliceosome
CG8451
AI388919
-0.152
6.32E-05
sodium-dependent multivitamin transporter
cation transport
CG7660
AI511691
-0.198
6.42E-05
pxt, peroxidase (EC:1.11.1.7)
defense response, phenylalanine and methane metabolism
CG5590
AI513117
-0.266
6.72E-05
oxidoreductase, acting on the CH-OH group of donors (EC:1.1.1.-)
-
CG4451
AI519539
-0.192
6.85E-05
Heparan sulfate 6-O-sulfotransferase (Hs6st) (EC:2.8.2.-)
heparan sulfate proteoglycan biosynthesis
CG10512
AI106900
-0.159
7.00E-05
oxidoreductase (EC:1.-.-.-)
carbohydrate metabolism
CG4475
AI134980
-0.202
7.21E-05
Imaginal disc growth factor 2 (Idgf2)
imaginal disc development
CG10667
AA391691
-0.182
7.28E-05
Origin recognition complex subunit 1 (Orc1), DNA binding
DNA replication initiation
CG1416
AI512102
-0.161
7.41E-05
-
-
CG15093
AI402055
-0.264
7.73E-05
3-hydroxyisobutyrate dehydrogenase (EC:1.1.1.31)
amino acid metabolism, pentose-phosphate shunt, valine metabolism
Supplementary Table 1 (continued)
Up-regulated genes
CG#
GenBank#
fold change
p-value
Gene ID
Process involved
CG8266
AI388236
-0.080
7.77E-05
sec31
exocytosis
CG8882
AA820418
-0.165
7.88E-05
Trip1, translation initiation factor
protein biosynthesis
CG6415
AI064147
-0.251
8.03E-05
aminomethyltransferase (EC:2.1.2.10)
glycine catabolism
CG16721
AI455390
-0.148
8.08E-05
receptor
development
CG5326
AI259766
-0.142
8.54E-05
acyltransferase (EC:2.3.1.-)
fatty acid metabolism
CG8728
AI402168
-0.156
8.58E-05
mitochondrial processing peptidase (EC:3.4.24.64)
proteolysis and peptidolysis
CG32920
AI513138
-0.135
8.61E-05
gene cassette
-
CG5170
AA950043
-0.126
8.70E-05
Dodeca-satellite-binding protein 1 (Dp1)
single-stranded DNA binding
CG12165
AI533169
-0.210
9.14E-05
Inner centromere protein (Incenp)
-
CG9128
AI109221
-0.091
9.91E-05
Sac1, polyphosphoinositide phosphatase
dorsal closure, amnioserosa morphology change
CG1656
AI402619
-0.157
9.93E-05
lectin-46Ca
galactose binding
Down-regulated genes
CG#
GenBank#
fold change
p-value
Gene ID
Process involved
CG8147
AI518552
1.441
2.82E-37
alkaline phosphatase (EC:3.1.3.1)
glycerolipid metabolism and folate biosynthesis, defense response
CG12298
AI455612
0.642
9.80E-25
subito (sub), Dub, mei-1794
motor activity, meiotic spindle assembly
CG8745
AA264907
0.568
2.53E-24
ornithine-oxo-acid transaminase (EC:2.6.1.13)
urea cycle and metabolism of amino groups, arginine and proline
CG9485
AI455746
0.363
3.94E-19
amylo-alpha-1,6-glucosidase (EC:3.2.1.33)
glycogen metabolism
CG7018
AI109004
0.190
7.80E-16
Ets at 65A (Ets65A), transcription factor
regulation of transcription, DNA-dependent
CG18330
AI405736
0.385
3.04E-15
CTP:phosphocholine cytidylyltransferase 2 (Cct2) (EC:2.7.7.15)
aminophosphonate and phospholipid metabolism, determination of adult life span
CG6126
AI109859
0.338
4.90E-15
organic cation transporter
carbohydrate metabolism, carbohydrate and cation transport
CG4491
AA949254
0.203
2.91E-12
no ocelli (noc), RNA polymerase II transcription factor
regulation of trancription
CG14021
AI238760
0.344
2.96E-12
-
-
CG8888
AI405864
0.253
3.57E-12
oxidoreductase, acting on CH-OH group of donors (EC:1.1.-.-)
visual perception
CG17762
AI292558
0.193
7.25E-12
tomosyn, syntaxin-1 binding
synaptic vesicle priming, neurotransmitter secretion
CG3971
AA391207
0.223
8.77E-12
Baldspot
ISP domain
CG9663
AI404538
0.157
1.36E-09
ABC transporter
lipid metabolism and transport
CG6933
AI259543
0.249
1.72E-09
structural constituent of peritrophic membrane
-
CG1275
AI456634
0.156
2.51E-09
electron transporter
electron transport
CG32464
AI134267
0.187
2.89E-09
l(3)82Fd
LysM domain
CG6218
AI402088
0.274
3.17E-09
carbohydrate kinase
carbohydrate metabolism
CG6447
AI516072
0.333
3.40E-09
-
-
Supplementary Table 1 (continued)
Down-regulated genes
CG#
GenBank#
fold change
p-value
CG11715
AI293200
0.190
6.17E-09
Gene ID
Process involved
xenobiotic metabolism and steroid biosynthesis
8.39E-09
Cyp4g15
Na + -driven anion exchanger 1 (Ndae1), sodium:bicarbonate
symporter
CG4675
AA567741
0.198
CG8509
AI405916
0.260
1.35E-08
protein tyrosine phosphatase activator
CG5992
AI455786
signal transduction
0.163
1.75E-08
Adenosine deaminase-related growth factor A (Adgf-A)
CG15771
-
AI402122
0.199
3.20E-08
-
Haloacid dehalogenase/epoxide hydrolase family domain
CG10530
AI258529
0.400
6.11E-08
Lcp65Ag1
structural constituent of larval cuticle
CG7018
AI387796
0.158
1.24E-07
Ets at 65A (Ets65A), transcription factor
regulation of transcription, DNA-dependent
CG3663
AI387408
0.193
1.44E-07
-
Isochorismatase hydrolase family domain
CG6575
AI135453
0.165
2.67E-07
gliolectin (glec), carbohydrate binding
neurogenesis
CG13252
AA696671
0.122
3.25E-07
-
-
CG7387
AI261116
0.129
3.63E-07
-
defense response
CG5275
AI062152
0.152
4.35E-07
Diphthamide methyltransferase (Dph5) (EC:2.1.1.98)
peptidyl-diphthamide biosynthesis from peptidyl-histidine
CG10214
AA539060
0.285
5.02E-07
oligonucleotidase (EC:3.1.13.3)
RNA catabolism
CG3006
AI404525
0.248
5.29E-07
Fmo-1, dimethylaniline monooxygenase (N-oxide-forming)
(EC:1.14.13.8), amino acid metabolism
-
AA979171
0.170
6.51E-07
-
-
CG7533
AI113466
0.177
8.31E-07
charybde (chrb)
negative regulator of growth
CG6291
AA541101
0.130
9.80E-07
Aminopeptidase P (ApepP), X-Pro aminopeptidase (EC:3.4.11.9)
proteolysis and peptidolysis
CG31140
AI135060
0.142
1.28E-06
diacylglycerol binding
intracellular signaling cascade, lipid metabolism, phosphorylation
CG9083
AI516432
0.207
1.31E-06
-
CG12529
AI531932
0.174
1.51E-06
Zwischenferment (Zw), glucose-6-phosphate 1-dehydrogenase
(EC:1.1.1.49)
CG3971
AI134173
0.204
1.60E-06
Baldspot
ISP domain
CG1615
AI405401
0.187
1.77E-06
Open rectifier K + channel 1 (Ork1)
potassium ion transport, transmission of nerve impulse
CG1915
AA696212
0.168
1.97E-06
sallimus (sls), myosin-light-chain kinase (EC:2.7.1.117)
mitotic chromosome condensation
CG9218
AI114156
0.205
2.23E-06
smooth (sm), RNA binding
mRNA processing
CG10366
AI401958
0.223
2.77E-06
transcription regulator
cell proliferation
CG2961
AI518507
0.130
3.18E-06
-
-
CG7995
AI387960
0.186
3.43E-06
glycerol kinase (EC:2.7.1.30)
glycerolipid metabolism
CG1827
AI405596
0.155
4.00E-06
N4-(beta-N-acetylglucosaminyl)-L-asparaginase (EC:3.5.1.26)
amino acid catabolism, glycoprotein degradation
CG13316
AI517751
0.134
4.21E-06
Mnt, transcription factor
regulation of transcription
CG32509
AI403916
0.154
4.63E-06
-
-
CG10132
AI260505
0.145
4.64E-06
-
WD-40 repeat domain
CG4291
AI386952
0.195
4.73E-06
FH1 domain binding
nuclear mRNA splicing, via spliceosome
ion transport
pentose-phosphate cycle and glutathione metabolism
Supplementary Table 1 (continued)
Down-regulated genes
CG#
GenBank#
fold change
p-value
Gene ID
Process involved
CG31795
AI513369
0.254
5.77E-06
ia2, transmembrane receptor protein tyrosine phosphatase
protein amino acid dephosphorylation
CG9659
AI062041
0.178
7.23E-06
egghead (egh), beta-1,4-mannosyltransferase (EC:2.4.1.-)
sugar metabolism
CG5150
AI064308
0.189
7.26E-06
alkaline phosphatase (EC:3.1.3.1)
glycerolipid metabolism and folate biosynthesis
CG31052
AI108479
0.178
7.56E-06
solute:hydrogen antiporter
regulation of pH
CG31918
AA951389
0.148
7.69E-06
-
-
-
AI107428
0.130
8.66E-06
-
-
CG17052
AI512047
0.150
8.72E-06
structural constituent of peritrophic membrane
chitin metabolism
CG16783
AI388181
0.146
1.07E-05
fizzy-related 2 (fzr2)
cell cycle, protein metabolism, proteolysis and peptidolysis
CG10069
AI542868
0.131
1.22E-05
glycerol-3-phosphate transporter
carbohydrate and lipid metabolism and transport
CG6133
AI513471
0.134
1.32E-05
DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37)
rRNA and methionine metabolism
CG17759
AA694764
0.144
1.33E-05
G protein alpha49B (Galpha49B), GTPase
phospholipase C activation
CG4462
AI114056
0.195
1.36E-05
organic cation porter
cation transport
CG17843
AI403451
0.168
1.39E-05
flavin-linked sulfhydryl oxidase
electron transport
CG11081
AA696184
0.170
1.51E-05
plexin A (plexA), semaphorin receptor
motor axon guidance
CG30246
AA951219
0.098
1.55E-05
-
-
CG13326
AI134452
0.188
1.59E-05
-
-
CG32345
AI532183
0.114
1.61E-05
-
-
CG17838
AI517404
0.155
1.64E-05
RNA binding
-
CG5461
AI135873
0.225
1.78E-05
bunched (bun), RNA polymerase II transcription factor
autophagic cell death, cell fate determination, peripheral nervous system development
-
AI062384
0.194
1.87E-05
-
-
CG11348
AI402216
0.270
1.87E-05
nicotinic Acetylcholine Receptor beta 64B (nAcRß-64B)
cation transport, nerve-nerve synaptic transmission
CG5411
AI389964
0.110
1.93E-05
Phosphodiesterase 8 (Pde8) (EC:3.1.4.-)
cyclic nucleotide metabolism, mesoderm development, signal transduction
CG1078
AI519148
0.113
1.96E-05
-
-
CG30079
AI064501
0.163
1.98E-05
-
-
CG1049
AI544037
0.172
2.13E-05
CTP:phosphocholine cytidylyltransferase 1 (Cct1) (EC:2.7.7.15)
aminophosphonate and phospholipid metabolism, determination of adult life span
CG3727
AI516652
0.138
2.33E-05
G-protein coupled receptor protein signaling pathway, axon guidance
CG18492
AI516414
0.109
2.38E-05
dreadlocks (dock), SH3/SH2 adaptor protein
TGF-ß activated kinase 1 (Tak1), MAP kinase kinase kinase
(EC:2.7.1.-)
CG32445
AI402194
0.153
2.40E-05
aldose 1-epimerase (EC:5.1.3.3)
monosaccharide metabolism
CG15208
AI388683
0.128
2.48E-05
-
-
CG1915
AA802415
0.157
2.52E-05
sallimus (sls), myosin-light-chain kinase (EC:2.7.1.117)
mitotic chromosome condensation
CG10137
AI404679
0.115
2.70E-05
glutamate, glycine and thienylcyclohexylpiperidine binding
glutamate metabolism
CG9902
AA803845
0.147
2.70E-05
-
-
apoptosis, defense response
Supplementary Table 1 (continued)
Down-regulated genes
CG#
GenBank#
fold change
p-value
Gene ID
Process involved
CG31546
AI106756
0.214
2.72E-05
oxidoreductase (EC:1.-.-.-)
metabolism
CG10479
AI294326
0.127
2.75E-05
-
-
CG1059
AI533392
0.179
2.82E-05
Karyopherin ß 3 (Karyß3), protein carrier
protein-nucleus import
CG1108
AI389293
0.111
2.93E-05
alpha-Esterase-6 (alpha-Est6), carboxylesterase (EC:3.1.1.1)
response to toxin
CG2010
AI406006
0.143
3.11E-05
-
-
CG18480
AI295324
0.191
3.15E-05
-
-
CG32555
AI387396
0.147
3.24E-05
RhoGAPp190, Rho GTPase activator
intracellular signaling cascade, transmission of nerve impulse
CG14791
AA736062
0.190
3.38E-05
Rab27, GTPase
endocytosis
CG8403
AI134772
0.308
3.55E-05
SP2353, receptor
cell adhesion
CG3691
AI295871
0.093
3.58E-05
Painting of fourth (Pof), RNA binding
protein biosynthesis
CG5589
AI520511
0.146
3.74E-05
RNA binding
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
CG3270
AI064647
0.250
3.74E-05
oxidoreductase (EC:1.-.-.-)
metabolism and electron transport
CG11325
AI389920
0.218
3.81E-05
Gonadotropin-releasing hormone receptor (GRHR), peptide receptor
G-protein coupled receptor protein signaling pathway, transmission of nerve impulse
CG5467
AI108226
0.150
3.89E-05
-
-
CG6332
AI108666
0.156
3.94E-05
-
-
CG17610
AA951623
0.125
4.09E-05
gurken (grk), epidermal growth factor receptor binding
signal transduction
CG30090
AI402445
0.188
4.26E-05
peptidase (EC:3.4.-.-)
amino acid biosynthesis
CG8793
AI519287
0.104
4.28E-05
-
-
CG9109
AI514189
0.143
4.28E-05
-
-
CG8604
AA540348
0.156
4.34E-05
Amphiphysin (Amph), protein binding
neurotransmitter secretion, receptor mediated endocytosis
CG6091
AA697008
0.126
4.51E-05
-
-
CG32223
AI533109
0.126
4.53E-05
-
-
CG4630
AI517260
0.144
4.76E-05
carnitine transporter
anion and carbohydrate transport
CG16820
AI292895
0.148
5.59E-05
-
-
CG18011
AI519515
0.117
5.74E-05
electron transporter
electron transport
CG10263
AI518418
0.115
5.91E-05
-
-
CG8708
AI387726
0.156
5.95E-05
transferase (EC:2.-.-.-)
protein amino acid glycosylation
CG30412
AI063680
0.132
6.06E-05
-
-
CG32613
AA801823
0.107
6.21E-05
-
-
CG32833
AI404053
0.314
6.48E-05
trypsin (EC:3.4.21.4)
proteolysis and peptidolysis
CG32331
AI514369
0.107
6.59E-05
-
-
CG10390
AA941062
0.156
6.69E-05
TBP-associated factor 6-like (Taf6L)
transcription initiation from Pol II promoter
Supplementary Table 1 (continued)
Down-regulated genes
CG#
GenBank#
fold change
p-value
Gene ID
Process involved
CG32633
AI515642
0.154
6.83E-05
-
-
CG1774
AI108790
0.167
7.27E-05
hydrolase (EC:3.-.-.-)
CG6936
AI533834
0.145
7.30E-05
methuselah (mth), G-protein coupled receptor
CG8327
AI109254
0.212
7.35E-05
Spermidine Synthase (SpdS) (EC:2.5.1.16)
lipid metabolism
determination of adult life span, response to stress and starvation, synaptic vesicle
exocytosis
spermidine biosynthesis, urea cycle and metabolism of amino groups, amino acid
metabolism
CG12063
AA951887
0.136
7.47E-05
-
Endoglin/CD105 antigen domain
CG11490
AA941889
0.119
7.51E-05
GTPase activator
intracellular protein transport
CG5522
AI455519
0.307
7.56E-05
guanyl-nucleotide exchange factor
G-protein coupled receptor protein signaling pathway
CG7110
AI533592
0.123
8.05E-05
-
-
CG30190
AI405937
0.120
8.08E-05
-
-
CG2198
AI520006
0.160
8.83E-05
Amalgam (Ama), antigen binding
CG4919
AI401896
0.141
9.41E-05
Glutamate-cysteine ligase modifier subunit (Gclm)
cell adhesion
glutamate-cysteine ligase (EC:6.3.2.2), glutathione biosynthesis, glutamate
metabolism
CG33006
AA391057
0.132
9.44E-05
-
gene cassete
CG10374
AI114088
0.293
9.83E-05
Lipid storage droplet-1 (Lsd-1)
lipid storage
CG3502
AA990723
0.122
9.84E-05
membrane alanyl aminopeptidase (EC:3.4.11.2)
proteolysis and peptidolysis
CG5405
AA695570
0.149
9.95E-05
Krueppel target at 95D (KrT95D)
protein-Golgi targeting
Supplementary Table 2 - Genes whose expression in nicotine food are significantly (p-value ≤ 0.001) correlated to survival time in NC population (amplified RNA)
CG#
GenBank #
p-value
Gene ID
Process involved
CG5295
AA735687
7.59676E-05
-
PLP-dependent transferase domain
CG11089
AA438421
9.24571E-05
phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
purine base metabolism, one carbon pool by folate
CG8169
AI541940
0.000171127
Pms2
nucleic acid binding, mismatch repair
CG4472
AI387590
0.000234539
Imaginal disc growth factor 1 (Idgf1)
cell-cell signaling, imaginal disc development, signal transduction
CG4233
AI389216
0.000321264
Glutamate oxaloacetate transaminase 2 (Got2)
aspartate transaminase (EC:2.6.1.1), neurotransmitter receptor metabolism
CG1583
AI514673
0.000339984
phospholipase A2 (EC:3.1.1.4)
lipid metabolism
-
AA802181
0.000484229
-
-
CG8293
AA990849
0.000524444
Inhibitor of apoptosis 2 (Iap2), ubiquitin-protein ligase (EC:6.3.2.19)
anti-apoptosis
CG2493
AI238263
0.000566118
lysosomal Pro-X carboxypeptidase (EC:3.4.16.2)
proteolysis and peptidolysis
CG11371
AI109558
0.000677996
debra (dbr)
ubiquitination
CG8474
AA246733
0.000710152
Meics, transcription factor
-
CG8774
AI388707
0.000785354
glutamyl aminopeptidase (EC:3.4.11.7)
proteolysis and peptidolysis
CG5955
AI387868
0.000817323
UDP-glucose 4-epimerase (EC:5.1.3.2)
galactose and nucleotide sugars metabolism
CG5753
AA438844
0.000927755
staufen (stau)
long-term memory, RNA binding
CG10245
AI532649
0.000989192
Cyp6a20
xenobiotic and steroid metabolism
Supplentary Table 2 - Genes whose expression in nicotine food are significantly (p ≤ 0.001) correlated to survival time in CA population (amplified RNA)
CG#
GenBank #
Gene ID
Process involved
CG32302
AI296934
0.000455973
p-value
chitin binding
chitin metabolism
CG17278
AI532483
0.000556929
-
proteinase inhibitor domain
CG7966
AI238295
0.000608736
selenium binding
defense response
-
AI292597
0.000631814
-
-
CG2955
AI238195
0.000676134
structural constituent of cytoskeleton
-
CG4370
AI134100
0.000698108
Inwardly rectifying potassium channel 2 (Irk2)
cation transport
CG14521
AI108872
0.000764676
-
cell adhesion
CG1609
AI455306
0.000795142
Gcn2, protein kinase (EC:2.7.1.37)
protein amino acid phosphorylation
CG6170
AI511948
0.000856462
HDAC6, histone deacetylase (EC:3.5.1.-)
regulation of cell cycle
CG31546
AI106756
0.000869719
oxidoreductase (EC:1.-.-.-)
metabolism
CG4916
AI455115
0.000952181
maternal expression at 31B (me31B), ATP-dependent RNA helicase
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Supplentary Table 3 - Genes whose expression in control food are significantly (p ≤ 0.0001) correlated to ornithine levels in NC population
spot
DN1285
DN4509
DN1709
DN3364
DN3767
DN0046
DN1288
DN0493
DN1419
DN3278
DN3367
DN0467
DN3000
Pr > F
3.25E-06
7.87E-06
9.85E-06
2.75E-05
4.4E-05
4.61E-05
5.32E-05
6.39E-05
7.82E-05
8.07E-05
8.13E-05
8.75E-05
8.76E-05
nlp
5.487574
5.104269
5.006659
4.560772
4.356621
4.336767
4.274248
4.194782
4.106935
4.093343
4.09013
4.057954
4.057672
CG#
CG10631
CG11961
CG6611
CG11063
CG8564
CG10908
CG10152
CG12123
CG16728
CG2994
CG6700
CG12112
CG7682
GenBank#
AI134421
AA202283
AI295651
AA951285
AI296209
AI109557
AI134729
AI063192
AA950502
AI388933
AI455698
AA803541
AI404773
Gene ID
ect (ectodermal)
beat-IV
-
Gene Onthology
nucleic acid binding
actin binding; thyroid hormone receptor binding; transcription regulator activity
metallocarboxypeptidase activity; proteolysis
peptidase activity; misfolded or incompletely synthesized protein catabolism
extracellular region
ARF GTPase activator activity; regulation of GTPase activity
oxidoreductase activity; metabolism
cyclin-dependent protein kinase regulator activity
Supplentary Table 3 - Genes whose expression in nicotine food are significantly (p ≤ 0.0001) correlated to ornithine levels in NC population
spot
DN0250
DN2687
DN0196
DN0751
DN0129
Pr > F
5.75E-06
6.99E-05
7.91E-05
7.94E-05
9.71E-05
nlp
5.240344
4.15528
4.102038
4.100374
4.012674
CG#
CG5915
CG6028
CG4338
CG7578
CG4229
GenBank#
AI063720
AI403860
AI515115
AA952110
AI512337
Gene ID
Rab7 (Rab-protein 7)
-
Gene Onthology
GTP binding; GTPase activity; intracellular protein transport; receptor mediated endocytosis
isomerase and lyase activity; amino acid catabolism
ARF guanyl-nucleotide exchange factor activity; exocytosis; intracellular protein transport
-
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