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Brook Brouha Personal information Birth date Birthplace Citizenship Medical License October 18, 1972 Radford, VA USA CA, AZ, TX, UT, PA Contact information 1319 Beryl St. San Diego, CA 92109 619-890-3600 [email protected] Education 2010 2009-2010 2009 2006-2009 2005-2006 2005 2003 1994 Research Experience 2006 2002-2003 2000-2002 1998-2000 1997 1992-1996 Teaching Experience 2003 1996-2000 1994-1996 1994-1996 Recent Work History 2015-present 2014-present 2010-2015 2009-2010 2005-2009 Board Certified, Dermatopathology Dermatopathology Fellowship, UT Southwestern, Cockerell & Assoc, Dallas, TX Board Certified, Dermatology -- Fellow of The American Academy of Dermatology Dermatology Residency, University of California, San Diego, San Diego, CA Transitional Intern, Scripps Mercy Hospital, San Diego, CA M.D. Penn, Philadelphia, PA Ph.D. (Genetics), Penn, Philadelphia, PA B.A. (Biochemistry), Summa Cum Laude, Dartmouth College, Hanover, NH Postdoctoral Fellow, UCSD Dept. of Dermatology (spring only), “Role of Vitamin D in Skin Defense,” Laboratory of Richard Gallo MD/PhD Postdoctoral Fellow, Huntsman Cancer Institute and Dept. of Dermatology, Univ. of Utah, “Apoptotic cleavage of Livin in Melanoma cells,” Laboratory of Douglas Grossman, MD PhD PhD thesis, Penn, “Active L1s in the Human Genome,” Laboratory of Haig H. Kazazian Jr., MD PhD rotation, Penn, “Role of Nuclear Ferritin in Corneal Epithelium,” Laboratory of Dwight Stambolian, MD PhD PhD rotation, Penn (summer only), “Sacrospinal innervation of Rat Bladder,” Laboratory of Richard Miselis, VMD PhD Predoctoral Fellow, NIH (summers only), “A Rat Model for Tardive Dyskinesia,” Laboratory of Thomas Hyde, MD PhD Abdominal fitness instructor, Jewish Community Center, Salt Lake City, UT MCAT instructor, private tutor, Philadelphia, PA MCAT instructor, Kaplan Test Review, Washington, DC Public School Teacher, 8th grade science, Fairfax County Public Schools, Fairfax VA Owner, BrouhaDerma, San Diego, CA Owner, Certified Dermatology, Inc. Yuma, AZ Owner, Compass Dermatopathology, Inc. La Jolla, CA Dermatologist (moonlighting- ½ day per week), Malouf Dermatology-Center for Skin and Cosmetic Dermatology, Fort Worth, TX Transitional internship (Scripps Mercy), Dermatology Residency (UCSD), Dermatopathology Fellowship (UTSW) Other Work Experience 1994-1996 Deck Construction (summers only), Phil Dileo Construction, Fairfax VA 1992-1993 Housekeeper (ski season only), Rustler Lodge, Alta, UT 1988 Lifeguard (summer only), Poplar Heights Pool, Falls Church, VA 1986-1996 Owner of landscaping business, Falls Church, VA Scholastic Honors UCSD Dermatology Residency (2006-2009) 2009 Pacific Dermatology Association, “Resident Case Presentation Contest,” Top Score by audience. Portland, OR 2009 American Academy of Dermatology. “Dermpath diagnostics--Dermpath Bowl.” Third place Nationally, Annual meeting, San Franscisco, CA 2009 American Academy of Dermatology. “Resident Jeopardy Competition.” Second Place Nationally, Annual meeting, San Francisco, CA. 2008 Pacific Dermatology Association. “Clincopatholical Correlation Conference.” First place – Best resident case. Annual meeting, San Francisco, CA 2007 American Society for Dermatopathology. “Duel in Dermatopathology.” First place – Best resident case presentation. Annual meeting, Baltimore, MD Scripps Mercy Transitional Internship (2005-2006) 2006 Geller award for top research presentation “Developing a mouse model to investigate the role of vitamin D in skin defense” 2006 EKG interpretation contest. Top overall score 32.5/33 University of Pennsylvania (1996-2005) 1996-2005 Pre-doctoral fellow, Penn, NIH NIGMS Medical Scientist Training Program (MSTP) 2003 Dr. Roy G. Williams Award - meritorious research in basic medical sciences Dartmouth College (1990-1994) 1994 Summa cum laude – class rank 3/1047 1993 Francis Townsend Scientific Award - top biology student at Dartmouth College 1993 Junior year (Early) Phi Beta Kappa 1990-1994 Rufus Choate Scholar (top 5%) 1990-1994 7 academic citations –music, computer science, biology, education, biophysical chemistry, economics Departmental and University Activities 2009-2010 UT Southwestern Department of Dermatology Grand Rounds 2006-2009 University of California San Diego Department of Dermatology Grand Rounds 2005-2006 Scripps Mercy Hospital Grand Rounds 2002-2003 Utah Department of Dermatology Grand Rounds 2000-2004 Penn MD PhD Retreat 1999-2004 Penn MD PhD Grand Rounds 1998-2002 Penn Genetics Journal Club Professional Societies and Activities 2013 -present 2009 -present 2007 -present 2007- 2009 2007 2002-2004 2002 1999-2002 2000 Mentoring Activities 2002 1999-2000 Noah Worcester Dermatologic Society Pacific Dermatology Association, Executive Committee Member American Academy of Dermatology American Society for Dermatopathology Society for Investigative Dermatology Society for Investigative Dermatology Human Genome Variation Society American Society of Human Genetics National M.D. Ph.D. Student conference Joshua Schustak, undergraduate, University of Pennsylvania Jessica Ngo, undergraduate, University of Pennsylvania Extracurricular Activities 2010 Dallas Tuesday Night Cyclocross Mens B class series leader 2005-present 250+ days longboard or shortboard surfing 1990-present 750+ days alpine or telemark skiing 2002 24 hours of Snowshoe mountain bike race, 3 rd place co-ed pro, 4-man team manager 2002 Philadelphia Freedom Submission Fighting Tournament, 2 nd Place gi, 2nd place no-gi, Blue Belt, 180-210lb weight class. 2001 Mr. Penn, bodybuilding, second place heavyweight 2001 Eastern Collegiate Criterium Road Race, 7th place, men’s A 2001 24 hours of Snowshoe mountain bike race, 4 th place co-ed pro, 4-man team captain 2001 Mid Atlantic Cup Mountain Bike Championship, 5th place expert/pro 2000 Eastern Collegiate Cycling Road Race, 2nd place, men’s B 2000 Mr. Penn, bodybuilding, contestant 1998-2002 Penn Cycling Mountain Bike Team Captain 1998-2000 Collegiate Mountain Bike Nationals (finishes include cross-country, men’s A top 30%(19982000); downhill, men’s A 33/118 (1999); downhill, men’s B 2 nd overall (2000)) 1997 Penn Cycling, Team won Eastern Collegiate Mountain Bike Championship. Individual 7 th overall (Penn top rider) 1990-1992 Varsity letter, gymnastics, Dartmouth College Invited Oral Presentations Brouha B, Bardan A, Ricotti C, Cockerell, C Cerebrotendinous Xanthomatosis. Resident Case Presentation Contest. Pacific Dermatology Assocoiation. Portland, OR 2009 Brouha B, Lee P, Bardan A, O’Grady T, Hansen D. A rare cause of lower extremity purpura. Resident Case Presentation Contest. Pacific Dermatology Assocoiation. San Francisco, CA 2008 Brouha B, Lee P, Bardan A, O’Grady T, Hansen D. A rare cause of lower extremity purpura. Duel in Dermatopathology Resident Competition. American Society of Dermatopathology. Baltimore, MD 2007. Brouha B, Lee P, Bardan A, O’Grady T, Hansen D. A rare cause of lower extremity purpura. Pacific Dermatology Association. Annual Meeting. San Francisco, CA 2008. Brouha B, Schauber J, Gallo R: Development of a mouse model to investigate the role for Vitamin D in Skin Defense. Geller Research Competition, Scripps Mercy Hospital, San Diego, CA 2006. Brouha B, Liu T, Hanks A, Yan H, Grossman D: Apoptotic cleavage of livin in melanoma cells. Society for Investigative Dermatology, Providence, RI, 2004 Brouha B, Schustak J, Badge R, Farley A, Moran JV, Kazazian HH Jr: Active L1s in the human genome. Human Genome Variation Society, Baltimore, MD, 2002. Brouha B, Schustak J, Badge R, Moran JV, Kazazian HH Jr: Active L1s in the human genome. East Coast Retrotransposon meeting, Fort Detrick, MD, 2002. Brouha B, Meischl C, Ostertag E, deBoer M, Zhang Y, Neijens H, Roos D, Kazazian HH Jr: Retrotransposition in human maternal meiosis I. Penn MD PhD student retreat, Bryn Mawr, PA. 2002. Brouha B, Badge RM, Ostertag E, Smit AF, Moran JV, Kazazian HH Jr: Toward a complete understanding of active L1s in the human genome. American Society of Human Genetics, San Diego, CA, 2001. Brouha B, Miselis R: Sacrospinal innervation of rat bladder, Penn Neuroscience student retreat, Philadelphia, PA, 1997. Publications (Peer-reviewed) Athalye L, Hamman MS, Dill S, Cunningham B, Brouha B. Congenital eosinophilic annular erythema, In preparation. 2011 Ali L, Gladsjo K, Brouha B, Cockerell C. A Patient with rapidly enlarging noduloulcerative lesions (Lues Maligna). In Press, Archives of Dermatology. Ali L, Brouha B, Bardan A, Hansen D. A cutaneous epithelioid hemangioendothelioma on the chest of a young girl. In press. Journal of Cutaneous Pathology Ali L, Brouha B, Ricotti C, Lili Li, Bardan A, Cockerell, X-Linked Dominant Conradi Hunnerman Happle Syndrome. American Journal of Dermatopathology, May;33(3)316, 331 2011 Chisholm C, Brouha B, Lee P, Hnasen D, Cockerell C. Lower Extremity Purpura in a Woman with Psychosis (Scurvy). Archives of Dermatology, Oct 146(10): 1167-72 2010. Chiang, C, Brouha B, Romero L, Erythematous Plaques involving calves, Archives of dermatology, Archives of Dermatology, Sep;145(9);1053-8. 2009 Schauber J, Dorschner RA, Yamasaki K, Brouha B, Gallo R: Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli. Immunology. 118(4):509519, 2006. Brouha B, Yan H, Liu T, Raj D, Biddle D, Lee R, Grossman D: Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase. Journal of Dermatological Science. (43)189-200, 2006. Liu T, Biddle D, Hanks A, Brouha B, Yan H, Lee R, Leachman S, Grossman D: Activation of dual apoptotic pathways in human melanocytes and protection by survivin. Journal of Investigative Dermatology. 126(10):2247-2256, 2006. Lavie L, Maldener E, Brouha B, Meese E, Mayer J: The human L1 promoter: variable transcription initiation sites and a major impact of upstream flanking sequence on promoter activity. Genome Research. 14:2253-2260, 2004. Liu T, Brouha B, Grossman D: Rapid induction of mitochondrial events and caspase-independent apoptosis in survivin-targeted melanoma cells. Oncogene. 23:1 39-48, 2004. Brouha B, Schustak J, Badge R, Lutz-Prigge S, Farley A, Moran JV, Kazazian HH Jr: Hot L1s account for the bulk of retrotransposition in the human population. PNAS. 100:5280-85, 2003. Brouha B, Meischl C, Ostertag E, deBoer M, Zhang Y, Neijens H, Roos D, Kazazian HH Jr: Evidence consistent with human L1 retrotransposition in maternal meiosis I. American Journal of Human Genetics. 71(2): 327-36, 2002. Abstracts and Posters Brouha B, Glass J, Calame A. A rare case of Restrictive Dermopathy. CPC presentation. Pacific Dermatology Association. Annual Meeting. Pasadena, CA 2010. Brouha B, Peckham R, Calame A. A rare case of Hunter Syndrome. CPC presentation. Pacific Dermatology Association. Annual Meeting. Pasadena, CA 2010. Jackson M, Hamman M, Gladsjo J, Garcia B, O’Grady T, Brouha B. Congenital Eosinophilic Annular Erythema. Abstract #1085 American Society of Dermatopathology. San Francisco, CA 2008. Brouha B, Bardan A, O'Grady T. Disseminated, but unilateral, HSV2 infection. Abstract. Pacific Dermatology Association. Annual Meeting. San Francisco, CA 2008. Brouha B, Lee P, Bardan A, O’Grady T, Hansen D. A rare cause of lower extremity purpura. Abstract #1058 American Society of Dermatopathology. Baltimore, MD 2007. Brouha B, Bardan A, O’Grady T, Hansen D. Cutaneous epithelioid hemangioendothelioma of the chest wall of a young girl. Abstract #1036 American Society of Dermatopathology. Baltimore, MD 2007. Brouha B, Bardan A, O’Grady T. Desmoplastic trichilemomma: a rare presentation in the axilla. Abstract #1081 American Society of Dermatopathology. Baltimore, MD 2007. Schauber J, Dorschner R, Coda A, Buchau A, Brouha B, Liu P, Kiken D, Helfrich Y, Kang S, Elalieh, H, Steinmeyer A, Zugel U, Bikle D, Modlin R, Gallo R: Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D dependent mechanism. Abstract: Journal of Investigative Dermatology. 127(S1): A778, 2007. Poster presentation: Society for Investigative Dermatology, Los Angeles, CA, 2007 Brouha B, Tiku A, Goradia A, Myers J: Infectious Hemoptysis with no Signs of Infection, Clinical Vignette Competition. Society of Hospital Medicine Annual Meeting, poster presentation, Chicago, IL 2005. Brouha B, Liu T, Hanks A, Yan H, Grossman D: Apoptotic cleavage of livin in melanoma cells. Abstract: Journal of Investigative Dermatology. 122(3): A150, 2004. Poster presentation: Society for Investigative Dermatology, Providence, RI, 2004. Biddle D, Hanks A, Liu T, Brouha B, Grossman D: 4-tert-butylphenol and UVB stimulate distinct apoptotic pathways in human melanocytes.. Abstract: Journal of Investigative Dermatology. 120(4), 2003. Poster presentation: Society for Investigative Dermatology, Miami, FL, 2003. Liu, T, Brouha B, Grossman D: Survivin targeting triggers rapid translocation of apoptosis inducing factor in melanoma cells. Abstract: Journal of Investigative Dermatology. 120(4), 2003. Poster presentation: Society for Investigative Dermatology, Miami, FL, 2003. Brouha B, Badge RM, Schustak J, Moran JM, Kazazian HH Jr.: Active L1 retrotransposons in the human genome. Abstract: American Journal of Human Genetics. 61(4): supplement, 2002. Poster presentation: American Society for Human Genetics, Baltimore, MD 2002. Brouha B, Badge RM, Ostertag E, Smit AF, Moran JV, Kazazian HH Jr.: Toward a complete understanding of active L1s in the human genome. Abstract: American Journal of Human Genetics. 69(4): supplement, 2001. Brouha B, Brooks D, Stambolian D: Role of nuclear ferritin in human corneal epithelial cells, Penn MD PhD student retreat, poster presentation, Bryn Mawr, PA, 2000. Featured in Powel, K. Stipend Survival: Nature. 428: 102-103, 2004. Most downloaded article of the month. References: Dr. Clay Cockerell, Fellowship Director, UT Southwestern, Dermatopathology [email protected] 490500-5062 Dr. Shiela Friedlander, Rady Children’s Hospital/UCSD Department of Dermatology (dermatology residency faculty advisor) [email protected] 858-755-3038 Dr. Richard Gallo, Professor and Chief, Division of Dermatology, UCSD (dermatology residency program director), [email protected] 619-742-7784 Dr. Haig Kazazian, Chair, Department of Genetics, Penn (PhD thesis advisor). [email protected], 215-898-3582 Dr. Thomas Hyde, Senior Scientist, Clinical Brain Disorder’s Branch, NIH (undergraduate research advisor). [email protected], 301-613-5964