Download 报告人简历 - 中国科学院上海药物研究所

周 虎 研究员
中国科学院上海药物研究所质谱组
教育背景：
2001.9 -- 2007.6，中国科学院上海生命科学研究院生物化学与细胞生物学研究所
生物化学与分子生物学博士学位 导师：曾嵘研究员
1997.9 -- 2001.7，南开大学生物系 生物学学士学位
研究经历：
2008.3 –2012.2，
加拿大渥太华大学系统生物学研究所，博士后兼质谱实验室主管
导师：Daniel Figeys 教授，博士
研究方向：神经退行性疾病相关的蛋白质组学和脂组学的研究
2006.10 -- 2008.1
中国科学院上海生命科学研究院生物化学与细胞生物学研究所，助理研究员
导师：曾嵘研究员，博士
研究方向：大鼠附睾组织中头部和尾部差异表达糖蛋白的定量蛋白质组学
获奖情况：

2009 年，获第 21 届国际生物化学与分子生物学联盟学术大会青年科学家论
坛（IUBMBYSP, 全球共 116 位）资助。

2010 年 10 月 ， Conference travel award of CIHR Training Program in
Neurodegenerative Lipidomics for the first China-Canada Systems Biology
Symposium.

2010 年至今，加拿大健康研究院（CIHR）神经退行性脂组学博士后奖学金
资助。

2011 年 7 月，CTPNL Conference Travel Award at the Ottwa Institute of Systems
Biology Research Symposia.

2011 年 12 月，CIHR Training Program in Neurodegenerative Lipidomics
outreach scholarship in the Systems Biology of Neurodegenerative Disease.
发表论文情况:
1.
Zhou H, Wang F, Yao Z, Wang Y, Ning Z, Hou W, Wright TG, Sundaram M,
Zhong S and Figeys D (2011) Improved Recovery and Identification of
Membrane Proteins from Rat Hepatic Cells using a Centrifugal Proteomic
Reactor. Mol Cell Proteomics. 2011 Oct;10(10):O111.008425.
2.
Zhou H, Hou W, Denis NJ, Zhou H, Vasilescu J, Zou H, Figeys D.
Glycoproteomic Reactor for Human Plasma. J Proteome Res. 2009
Feb;8(2):556-66.
3.
Zhou H, Ning Z, E Starr A, Abu-Farha M, Figeys D. Advancements in
top-down proteomics. Anal Chem. 2012 Jan 17;84(2):720-34.
4.
Zhou H*, Ning Z*, Wang F, Seebun D, Figeys D. Proteomic reactors and
their applications in biology. FEBS J. 2011 Oct;278(20):3796-806. (* indicates
equal contribution)
5.
Zhou H, Hou W, Lambert JP, Tian R and Figeys D. Analysis of
Low-abundance Proteins using the Proteomic Reactor with pH Fractionation.
Talanta. 2010 Feb; 80(4):1526-1531.
6.
Zhou H, Hou W, Lambert JP, Figeys D. New ammunition for the proteomic
reactor: strong anion exchange beads and multiple enzymes enhance protein
identification
and
sequence
coverage.
Anal
Bioanal
Chem.
2010
Aug;397(8):3421-30.
7.
Zhou H, Dai J, Sheng QH, Li RX, Shiel CH, Guttman A, Zeng R. A fully
automated two-dimensional liquid chromatography mass spectrometry
method utilizing online continuous pH and reverse phase gradients for global
proteome analysis. Electrophoresis. 2007 Dec;28(23):4311-9.
8.
Zhou H*, Chen B*, Li RX, Sheng QH, Li SJ, Zhang L, Li L, Xia QC, Wang
HY, Zeng R. Large-scale identification of human biliary proteins from a
cholesterol stone patient using a proteomic approach. Rapid Commun Mass
Spectrom. 2005; 19(23):3569-78. (* indicates equal contribution)
9.
Ning Z*, Zhou H*, Wang F, Abu-Farha M, Figeys D. Analytical Aspects of
Proteomics: 2009-2010. Anal Chem. 2011 Jun 15;83(12):4407-26. (* indicates
equal contribution)
10. Hou W*, Zhou H*, Elisma F*, Bennett SA, Figeys D. Technological
developments in lipidomics. Brief Funct Genomic Proteomic. 2008
Sep;7(5):395-409. (* indicates equal contribution)
11. Qin W, Sundaram M, Wang Y, Zhou H, Zhong S, Chang CC, Manhas S, Yao
EF, Parks RJ, McFie PJ, Stone SJ, Jiang ZG, Wang C, Figeys D, Jia W, Yao Z.
Missense mutation in APOC3 within the C-terminal lipid-binding domain of
human
apoC-III
results
in
impaired
assembly
and
secretion
of
triacylglycerol-rich very low density lipoproteins: Evidence that APOC-III
plays a major role in the formation of lipid precursors within the microsomal
lumen. J Biol Chem. 2011 Aug 5;286(31):27769-80.
12. Hou W, Zhou H, Khalil MB, Seebun D, Bennett SA, Figeys D. Lyso-form
fragment ions facilitate the determination of stereospecificity of diacyl
glycerophospholipids.
Rapid
Commun
Mass
Spectrom.
2011
Jan
15;25(1):205-17
13. Jiang XS, Zhou H, Zhang L, Sheng QH, Li SJ, Li L, Hao P, Li YX, Xia QC,
Wu JR, Zeng R. A high-throughput approach for subcellular proteome:
identification of rat liver proteins using subcellular fractionation coupled with
two-dimensional liquid chromatography tandem mass spectrometry and
bioinformatic analysis. Mol Cell Proteomics. 2004; 3(5):441-55.
14. Li RX, Zhou H, Li SJ, Sheng QH, Xia QC, Zeng R. Prefractionation of
proteome by liquid isoelectric focusing prior to two-dimensional liquid
chromatography mass spectrometric identification. J Proteome Res. 2005;
4(4):1256-64.
15. Yuan H, Liu A, Zhang L, Zhou H, Wang Y, Zhang H, Wang G, Zeng R, Zhang
Y, Chen Z. Proteomic profiling of regionalized proteins in rat epididymis
indicates consistency between specialized distribution and protein functions. J
Proteome Res. 2006; 5(2):299-307.
16. Jiang XS, Tang LY, Cao XJ, Zhou H, Xia QC, Wu JR, Zeng R.
Two-dimensional
gel
electrophoresis
maps
of
the
proteome
and
phosphoproteome of primitively cultured rat mesangial cells. Electrophoresis.
2005; 26(23):4540-62.
17. Dai J, Shieh CH, Sheng QH, Zhou H, Zeng R. Proteomic analysis with
integrated multiple dimensional liquid chromatography/mass spectrometry
based on elution of ion exchange column using pH steps. Anal Chem. 2005;
77(18):5793-9.
18. Li D, Fu Y, Sun R, Ling CX, Wei Y, Zhou H, Zeng R, Yang Q, He S, Gao W.
pFind: a novel database-searching software system for automated peptide and
protein identification via tandem mass spectrometry. Bioinformatics. 2005;
21(13):3049-50.
19. Jiang XS, Tang LY, Dai J, Zhou H, Li SJ, Xia QC, Wu JR, Zeng R.
Quantitative analysis of severe acute respiratory syndrome (SARS)-associated
coronavirus-infected cells using proteomic approaches: implications for
cellular responses to virus infection. Mol Cell Proteomics. 2005; 4(7):902-13.
20. Li RX, Chen HB, Tu K, Zhao SL, Zhou H, Li SJ, Dai J, Li QR, Nie S, Li YX,
Jia WP, Zeng R, Wu JR. Localized-statistical quantification of human serum
proteome associated with type 2 diabetes. PLoS ONE. 2008 Sep
16;3(9):e3224.
21. Li C, Tan YX, Zhou H, Ding SJ, Li SJ, Ma DJ, Man XB, Hong Y, Zhang L,
Li L, Xia QC, Wu JR, Wang HY, Zeng R. Proteomic analysis of hepatitis B
virus-associated hepatocellular carcinoma: Identification of potential tumor
markers. Proteomics. 2005; 5(4):1125-39.
22. Yao Y, Hong S, Zhou H, Yuan T, Zeng R, Liao K. The differential protein and
lipid compositions of noncaveolar lipid microdomains and caveolae. Cell Res.
2009 Apr;19(4):497-506
23. Jin WH, Dai J, Zhou H, Xia QC, Zou HF, Zeng R. Phosphoproteome analysis
of mouse liver using immobilized metal affinity purification and linear ion
trap
mass
spectrometry.
Rapid
Commun
Mass
Spectrom.
2004;
18(18):2169-76.
24. Li C, Yi-Hong, Tan YX, Ai JH, Zhou H, Li SJ, Zhang L, Xia QC, Wu JR,
Wang HY, Zeng R. Analysis of microdissected cells by two-dimensional
LC-MS approaches. Methods Mol Biol. 2008;428:193-208.
25. Fu Y, Gao W, He S, Sun R, Zhou H, Zeng R. Mining tandem mass spectral
data to develop a more accurate mass error model for peptide identification.
Pac Symp Biocomput. 2007:421-32.
26. Zeng R, Yang RF, Shi MD, Jiang MR, Xie YH, Ruan HQ, Jiang XS, Shi L,
Zhou H, Zhang L, Wu XD, Lin Y, Ji YY, Xiong L, Jin Y, Dai EH, Wang XY,
Si BY, Wang J, Wang HX, Wang CE, Gan YH, Li YC, Cao JT, Zuo JP, Shan
SF, Xie E, Chen SH, Jiang ZQ, Zhang X, Wang Y, Pei G, Sun B, Wu JR.
Characterization of the 3a protein of SARS-associated coronavirus in infected
vero E6 cells and SARS patients. J Mol Biol. 2004; 341(1):271-9.
27. Zeng R, Ruan HQ, Jiang XS, Zhou H, Shi L, Zhang L, Sheng QH, Tu Q, Xia
QC, Wu JR. Proteomic analysis of SARS associated coronavirus using
two-dimensional
liquid
chromatography
mass
spectrometry
and
one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis
followed by mass spectrometric analysis. J Proteome Res. 2004; 3(3):549-55.
28. Ding SJ, Li Y, Shao XX, Zhou H, Zeng R, Tang ZY, Xia QC. Proteome
analysis of hepatocellular carcinoma cell strains, MHCC97-H and
MHCC97-L, with different metastasis potentials. Proteomics. 2004;
4(4):982-94.
29. Li C, Hong Y, Tan YX, Zhou H, Ai JH, Li SJ, Zhang L, Xia QC, Wu JR,
Wang HY, Zeng R. Accurate qualitative and quantitative proteomic analysis
of clinical hepatocellular carcinoma using laser capture microdissection
coupled with isotope-coded affinity tag and two-dimensional liquid
chromatography
mass
spectrometry.
Mol
Cell
Proteomics.
2004;
3(4):399-409.
30. Abu-Farha M, Elisma F, Zhou H, Tian R, Zhou H, Asmer MS, Figeys D.
Proteomics: from technology developments to biological applications. Anal
Chem. 2009 Jun 15;81(12):4585-99.
31. Bou Khalil M, Hou W, Zhou H, Elisma F, Swayne LA, Blanchard AP, Yao Z,
Bennett SA, Figeys D. Lipidomics era: accomplishments and challenges.
Mass Spectrom Rev. 2010 Nov-Dec;29(6):877-929.
32. Zhong S, Magnolo AL, Sundaram M, Zhou H, Yao EF, Leo ED, Loria P,
Wang S, Bamji-Mirza M, Wang L, McKnight J, Figeys D, Wang Y, Tarugi P,
Yao Z. Nonsynonymous mutations within APOB in human familial
hypobetalipoproteinemia - evidence for feedback inhibition of lipogenesis and
post-endoplasmic reticulum degradation of apolipoprotein B. J Biol Chem.
2010 Feb 26;285(9):6453-64.
33. Sundaram M, Zhong S, Bou Khalil M, Zhou H, Jiang ZG, Zhao Y, Iqbal J,
Hussain MM, Figeys D, Wang Y, Yao Z. Functional analysis of the missense
APOC3 mutation Ala23Thr associated with human hypotriglyceridemia. J
Lipid Res. 2010 Jun;51(6):1524-34.
34. Tian R, Wang S, Elisma F, Li L, Zhou H, Wang L, Figeys D. Rare Cell
Proteomic Reactor Applied to Stable Isotope Labeling by Amino Acids in
Cell Culture (SILAC)-based Quantitative Proteomics Study of Human
Embryonic Stem Cell Differentiation. Mol
Cell Proteomics. 2011
Feb;10(2):M110.000679.
35. Zhou H, Elisma F, Denis NJ, Wright TG, Tian R, Zhou H, Hou W, Zou H,
Figeys D. Analysis of the subcellular phosphoproteome using a novel
phosphoproteomic reactor. J Proteome Res. 2010 Mar 5;9(3):1279-88.
36. Wang S, Circu ML, Zhou H, Figeys D, Aw TY, Feng J. Highly sensitive
detection of S-nitrosylated proteins by capillary gel electrophoresis with laser
induced fluorescence. J Chromatogr A. 2011 Sep 23;1218(38):6756-62.
37. Mitchell L, Lau A, Lambert JP, Zhou H, Fong Y, Couture JF, Figeys D, Baetz
K. Regulation of Septin Dynamics by the Saccharomyces cerevisiae Lysine
Acetyltransferase NuA4.
PLoS One. 2011;6(10):e25336.