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From: A System-Level Transcriptomic Analysis of Schizophrenia Using Postmortem Brain Tissue Samples
Arch Gen Psychiatry. 2012;69(12):1205-1213. doi:10.1001/archgenpsychiatry.2012.704
Figure Legend:
Figure 1. Gene expression changes in the cerebral cortex of persons with schizophrenia (SZ). A, Venn diagram depicting the
overlap of genes differentially expressed between persons with SZ and controls in Brodmann areas (BAs) 21, 32, 38, and 46.
Differential expression was assessed with unpaired 2-class test analysis (using the significance analysis of microarrays package) at
a false discovery rate of less than 0.05 and a fold change of greater than 1.3. B, Differentially expressed genes between persons
with SZ and controls in each BA and paired overlap
analysis
between
the 4Medical
BAs assessed with the hypergeometric distribution. C,
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Heat of
map
of top 200
genes differentially expressed
between
SZ
and
control
samples of the cerebral cortex in BAs 21, 32, and 38.
Association. All rights reserved.
Scaled expression values are color-coded. The dendrogram depicts hierarchical clustering based on the Euclidean distance and the
From: A System-Level Transcriptomic Analysis of Schizophrenia Using Postmortem Brain Tissue Samples
Arch Gen Psychiatry. 2012;69(12):1205-1213. doi:10.1001/archgenpsychiatry.2012.704
Figure Legend:
Figure 2. Gene coexpression modules associated with schizophrenia (ie, visualization of the OLIG 1 [A] and GABA [B] modules). The
heat map of intramodular expression genes is shown in the top of the left side for each module, and the corresponding module
eigengene values, across samples according to Brodmann area (BA), are shown on the middle left side (black, BA 21; red, BA 32;
green, BA 38; blue, BA 46). Visualization of the OLIG1 and GABA modules is provided on the right side. The top 1000 connections
are shown for each module on the top right side,Copyright
according
to a degree-sorted
circle layout. The intramodular hubs are shown in
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5/5/2017where the relevant gene ontology categories enriched in the OLIG and GABA modules are listed on the
largerofsize
at the bottom,
1
Association. All rights reserved.
bottom left side.
From: A System-Level Transcriptomic Analysis of Schizophrenia Using Postmortem Brain Tissue Samples
Arch Gen Psychiatry. 2012;69(12):1205-1213. doi:10.1001/archgenpsychiatry.2012.704
Figure Legend:
Figure 3. Genome-wide association enrichment analysis of modules associated with schizophrenia (SZ). Several genome-wide
association studies examining a variety of illnesses using several cohorts (eg, SZ from the Psychiatric Genomics Consortium
[PGC_SZ], bipolar disorder from the PGC [PGC_BD], attention-deficit/hyperactivity disorder [ADHD], and major depression disorder
[MDD]) and 3 nonpsychiatric disease studies as negative controls in human immunodeficiency virus (HIV), psoriasis, and Parkinson
disease (PD) were included. Single-nucleotide polymorphisms
located
within
the transcript boundaries and an additional 20 kilobase
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the 3′ end of the gene were included
in
the
gene
set
analysis
Association. All rights reserved. method. The analyses presented here are based on
k = 5. For multiple testing corrections, a Benjamini-Hochberg correction was applied, and α was set at 10−4.
From: A System-Level Transcriptomic Analysis of Schizophrenia Using Postmortem Brain Tissue Samples
Arch Gen Psychiatry. 2012;69(12):1205-1213. doi:10.1001/archgenpsychiatry.2012.704
Figure Legend:
Figure 4. Cortical interregional differences shown as diminished in schizophrenia (SZ). A, Venn diagram depicting the overlap of
differentially expressed genes between persons with SZ and controls in all regions (611 genes) and genes differentially expressed
among the 4 different Brodmann areas (BAs) in controls (681 genes) and persons with SZ (82 genes). The 42 genes (in red font)
are the genes that overlap between differentially expressed genes between persons with SZ and controls in all regions and genes
differentially expressed among the 4 different BAs
in controls.
B, American
The 42 genes
are differentially expressed among BAs in control
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samples
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different expression levels in control
samples
compared
with
Association. All rights reserved. SZ samples. The horizontal bars show the −log P
values for differential expression among all BAs in SZ and control groups. The majority (n = 34) of these genes (ie, those with an
From: A System-Level Transcriptomic Analysis of Schizophrenia Using Postmortem Brain Tissue Samples
Arch Gen Psychiatry. 2012;69(12):1205-1213. doi:10.1001/archgenpsychiatry.2012.704
Figure Legend:
Figure 5. A hypothetical model based on the current data according to the disconnectivity hypothesis in schizophrenia.
Date of download: 5/5/2017
Copyright © 2012 American Medical
Association. All rights reserved.