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UNIVERSITY OF MIAMI SCHOOL OF MEDICINE Curriculum Vitae Date: March 29, 2005 l. PERSONAL Name: Judith Hurley, M.D. Office Phone: 305-585-5196 Academic Rank: Associate Professor of Clinical Medicine Primary Department: Secondary Appointment: Department of Internal Medicine Hematology/ Oncology Division None Citizenship: USA II.HIGHER EDUCATION Institutional: 5/19/78 6/19/84 Yale University BA Upstate Medical Center, Syracuse, NY MD Non-Institutional: Board Certification: National Board of Medical Examiners Part 1,2 & 3 1988 American Board of Internal Medicine 1991 American Board of Internal Medicine, Medical Oncology 2001 American Board of Internal Medicine, Medical Oncology Licensure: 1991 Florida Medical License ME0058981 lll.EXPERIENCE Academic: 7/84-6/85 Intern, OB/GYN, SUNY, Syracuse, NY 7/85-6/86 Intern, Internal Medicine, SUNY, Syracuse, NY 7/86-6/88 Resident, Internal Medicine, SUNY, Syracuse, NY 7/88-9/89 Fellow, Hematology/Oncology, SUNY, Syracuse, NY 10/89-6/90 Fellow, Hematology, New York University, NY 7/90-6/91 Fellow, Medical Oncology, Jackson Memorial Hospital, Miami, FL 7/91-6/02 Assistant Professor of Clinical Medicine, University of Miami Medical School 7/02-present Associate Professor of Clinical Medicine, University of Miami Medical School Hospital Appointments: Jackson Memorial Hospital, Attending Physician,1991-present University of Miami Hospital and Clinic, Attending Physician,1991present VA Medical Center, Attending Physician, 1991-2002 Non-Academic: 1979 7/1991-present 7/1998-present Military: Lab Technician, Rockefeller University Director, Hematology/Oncology Clinics, Jackson Memorial Hospital, Miami Consultant Medical Oncologist, Taylor Breast Center, Jackson Memorial Hospital, Miami None IV.PUBLICATIONS JOURNAL ARTICLES: Feun , Marini , Moffat , Savaraj , Hurley , and Mazumder . Cyclosporine A, alpha-interferon and interleukin-2 following chemotherapy with BCNU, DTIC, cisplatin, and tamoxifen: A Phase II study in advanced melanoma. Cancer Investigation 1:3-8, 2005 Hurley, Doliny, Reis, Silva, Gomez, De Zarraga, Welsh and Powell. Weekly Docetaxel and Carboplatin as Primary Systemic Therapy for HER-2 negative Locally Advanced Breast Cancer. Clinical Breast Cancer Vol 5 No 6(2005) pp 447-54 Lee, Doliny, Gomez-Fernandez, Powell, Reis and Hurley. Docetaxel and Cisplatin as Primary Chemotherapy for the Treatment of Locally Advanced Breast Cancers. Clin Breast Cancer Vol 5 No 5(2004) pp 371-6. Anderson, Mendoza, Payne, Valero, Palos, Nazario, Richman, Hurley, Gning, Lynch, Kalish and Cleeland. Pain Education for Underserved Minority Cancer Patients: A Randomized Controlled Trial. Journal of Clinical Oncology Vol 22 No 24 (2004) pp4918-25. Hernandez-Reif, Ironson, Field, Hurley, Katz, Diego, Weiss, Fletcher, Schanberg, Kuhn and Burman. Breast Cancer Patients have Improved Immune and Neuroendocrine Functions following Massage Therapy. Journal of Psychosomatic Research 57 (2004) 45-52. Anderson, Richman, Hurley, Palos, Valero, Mendoza , Gning and Cleeland. Cancer Pain Management Among Minority Outpatients: Perceived Needs and Barriers to Optimal Control. Cancer 2002; Vol 94, No 8: 2295-2304. Feun, Savaraj, Hurley and Marini. Phase II Trial of Paclitaxel and Dacarbazine with Filgastim Administration in Advanced Malignant Melanoma. Cancer Investigations 2002; Vol.20(3), 357361. Hurley, Franco, Gomez-Fernandez, Reis, Velez, Doliny, Harrington, Wilkerson and Lee. Breast Cancer and Human Immunodeficiency Virus: A Report of Twenty Cases. Clinical Breast Cancer 2001; Vol 2, No 3:215-22. Guatam and Hurley. Phase II Study of Neoadjuvant Herceptin, Taxotere and Cisplatin in the Treatment of Locally Advanced and Inflammatory Breast Cancer. Advances in Breast Cancer;2001: Vol 3, No.3:5-7 Anderson, Mendoza, Valero, Richman, Russell, Hurley, DeLeon, Washington, Palos, Payne and Cleeland. Minority Cancer Patients and their Providers: Pain Management Attitudes and Practice. Cancer 2000;88:1929-38. Feun, Savaraj, Hurley, Marini and Lai. A Clinical Trial of Intravenous Vinorelbine Tartrate plus Tamoxifen in the Treatment of Patients with Advanced Malignant Melanoma. Cancer 2000;83:584-8. Raez, Cabral,Cai, Landy, Sfakianakis, Byrne, Hurley, Scerpella, Jayweera and Harrington. Treatment of AIDS-Associated Primary Central Nervous System Lymphoma with Zidovidine, Ganciclovir and Interleukin 2. Aids Research and Human Retroviruses 1999;15:713-8. Morrell, Lee, Hurley, Arias, Mies, Richman, Fernandez, Donofrio, Raub and Cassileth. Phase II Trial of Neoadjuvant Methotrexate, Vinblastine, Doxorubicin and Cisplatinum (MVAC) in the Treatment of Locally Advanced Breast Cancer (LABC). Cancer 1998;82:503-11 Kolber, Hurley, Moreno and Cabral. In Vitro Enhancement of T-Cell Receptor-Targerted Lysis after IL-2 Treatment of PBL from HIV-Seropsitive Individuals. Clinical Immunology and Immunopathology 1998; 86:226-34. Feun, Savaraj, Soloman, Liebman and Hurley. Phase II Trial of Mitoxantrone, and Cisplatin in Advanced Non-Small Cell Lung Cancer. American Journal of Clinical Oncology 1996;19:190-2. Feun, Savaraj, Moffat, Robinson, Liebman, Hurley, Raub and Richman. Phase II Trial of Recombinant Interferon- with BCNU, Cisplatin, DTIC and Tamoxifen in Advanced Malignant Melanoma. Melanoma Research 1995;5:273-6. ABSTRACTS: Hurley, Doliny, Reis, DeZarraga, Gomez, Velez, Powell. Platinum Salts and Docetaxel as primary therapy of locally advanced and inflammatory breast cancer:the final report of three sequential studies. Breast Cancer Res Treat 2003; Vol 77 Hurley, Lunn, Turnquest, Reis, Doliny, Donenberg, De Zarraga, Mirhashemi. Breast Cancer in the Bahamas:preliminary evidence for an increase in genetic risk. ASCO Proceedings. 2003. Doliny, Velez, Jorda, Powell, Reis, Tang, Shonukan, Hurley. Weekly Carboplatin and Docetaxel as neoadjuvant therapy in locally advanced and inflammatory breast cancer. ASCO Proceedings, 2003. De Zarraga, Doliny, Reis, Powell, Velez, Gomez, Tang, Hurley. Cardiotoxicity of neoadjuvant Herceptin, Docetaxel and Cisplatin is related to BMI. ASCO Proceedings, 2003. Morrell, Lee, Reis, Hurley. MVAC as neoadjuvant therapy in locally advanced and inflammatory breast cancer: A ten year update. ASCO Proceedings, 2003. Wang H, Hurley J, Jorda M, Gomez-Fernandez C. Gene Amplification and Protein Overexpression of HER2 in Gastric Adenocarcinoma. Modern Pathology 2003; (16):612A. Hurley, Doliny, Silva, Powell, Shayker, Velez, Reis and Lee. Is there an alternative to anthracycline based chemotherapy: an evaluation of a non-anthracycline containing regimen as neoadjuvant therapy in locally advanced and inflammatory breast cancer. Breast Can Res Treat 2002;Vol 76, Supplement 1, No #155. Hurley, Doliny, Silva, Gomez-Fernandez, Reis, Velez, Castillo, Bateman, Franco, Guatam. Neoadjuvant Herceptin/Taxotere/Cisplatin in the Treatment of Locally Advanced and Inflammatory Breast Cancer. ASCO Proceedings, No.196 , 2002. Franco, Silva, Bateman, Doliny, Jorda, Castillo, Reis, Velez and Hurley. Neoadjuvant treatment of locally advanced and inflammatory breast cancer with weekly taxotere and carboplatin in tumors that do not overexpress her-2. ASCO Proceedings, No 2048, 2002. Hurley, Doliny, Velez, Guatam, Reis, Silva, Gomez-Fernandez, Lee and Franco. High Rate of Axillary Node Clearance with Neoadjuvant Herceptin, Taxotere and Cisplatin in Locally Advanced and Inflammatory Breast Cancer. Breast Cancer Research and Treatment 2001;Vol 69, No 3 #516 Hurley, Franco, Velez, Doliny, Gomez-Fernandez, Powell and Lee. Primary Therapy with Herceptin, Taxotere and Cisplatin in Locally Advanced and Inflammatory Breast Cancer. ASCO Proceedings, No.1871, 2001. Feun, Mazumder, Marini, Elgart, Hurley and Savaraj. A Pilot Study of the Initiation of Autoimmune Reaction to Tumor in Melanoma Patients by Cyclosporine A, Alpha Interferon and Interleukin-2 following Chemotherapy with BCNU, DTIC, Cisplatin and Tamoxifen. ASCO Proceedings, No., 2001. Harrington, Hurley, Cabral, Cohen, Hamilton, Byrne and Byrnes. Phase II Trial of Chemotherapy with and without Antiretroviral Therapy in the Treatment of AIDS Associated Large Cell Lymphoma. ASCO Proceedings, No.75, 2000. Hurley, Doliny, Gomez,Raez, Boggs, Franco and Lee. High Complete Response Rate of Locally Advanced Breast Cancer (LABC) to Neoadjuvant Docetaxel and Cisplatin Chemotherapy. ASCO Proceedings, No 494, 2000 Feun, Savaraj, Hurley and Marini. Phase II Trial of Taxol and DTIC with Filgrastim Administration in advanced Malignant Melanoma-Final Report. ASCO Proceedings, No. 2252, 2000. Hurley J, Lee Y, Boggs J and Franco S. Breast Cancer and Human Immunodeficiency Virus: A Report of Sixteen Cases. Breast Cancer Research and Treatment 1999,Vol 67, No. # 139. Doliny, Hurley, Raez, Boggs, Mies, Cassileth and Lee. Phase II Trial of Neoadjuvant Docetaxel and Cisplatinum for the Treatment of Locally Advanced Breast Cancer. ASCO Proceedings, No. 319, 1999 Lee, Hurley, Antunez, Cohen, Arias et al The Use of Vinorelbine and G-CSF in the Treatment of Poor Prognosis Acute Myeloid Leukemia. ASCO Proceedings No. 116, 1999 Hurley, Restrepo,Boggs, Lee et al The Use of Neoadjuvant Doxil in the Treatment of Stage III Breast Cancer. ASCO Proceedings, No.359, 1999 Lee, Manocha, Hurley, Lema and Cassileth, Use of Vinblastine in the Treatment of Poor Prognosis Acute Myelocytic Leukemias, 8th International Congress on Anticancer Treatment, Paris, February 3, 1998 Raez, Hurley, Jayweera, Scerpella, Landy, Cai, Sfakanakis, Cabral and Harrington. Treatment of Aids related Primary Central Nervous System Lymphomas with Azothymidine, Gancylovir and Interleukin 2. Blood, 1997;90: 342. Morrell, Lee, Hurley, Arias, Richman and Cassileth, Phase II Trial of Neoadjuvant Methotrexate, Vinblatine, Doxorubicin and Cisplatin in the Treatment of Locally Advanced Breast Cancer, Proceedings of the American Society of Clinical Oncology, Vol. 16, 1997,pp V.PROFESSIONAL- FUNDED RESEARCH National Cancer Institute Pain Symptoms of Cancer: Assessment and Treatment 2-R01 CA06582 PI: Charles Cleeland,M.D. (MD Anderson) (Role on Project: Collaborator 15%) 2/1/2005Total direct costs: $216,075 Indirect costs: National Institute of Health Southeastern AIDS Oncology Consortium (AIDS Malignancy Consortium Clinical Trials Grant) 1-UO1 CA 700580-03 PI: William Harrington, M.D.(University of Miami) (Role on Project: Consultant, 15%) 8/1/99-7/31/04 Total direct costs: $227,393/year Indirect costs: National Cancer Institute Cancer Pain Relief Skills for Minority Outpatients 1-U01 CA-93-45 PI Charles Cleeland, M.D. (M.D. Anderson) (Role on Project: Collaborator, 10%) Total direct costs: $90,641 3/1/97-5/31/99 Indirect costs: $48,040 Avon Research and Care Network Program for the Medically Underserved Breast Cancer Patient PI: Judith Hurley, M.D. 6/1/02-6/1/04 Total direct costs: $450,000 Indirect costs: $50,000 Aventis Pharmaceuticals, Inc. Phase II Trial of Dose Dense Herceptin, Taxotere and Carboplatin in the Treatment of Breast Cancer. PI: Judith Hurley, M.D. 6/1/05-6/1/06 Total direct costs: $147,750 Indirect costs: $48,250 Aventis Pharmaceuticals, Inc. Phase II Trial of Weekly Taxotere and Carboplatin in the Treatment of Locally Advanced and Inflammatory Breast Cancer. PI: Judith Hurley, M.D. 3/1/01-3/1/03 Total direct costs: $147,750 Indirect costs: $48,250 Aventis Pharmaceuticals, Inc. Phase II Trial of Neoadjuvant Docetaxel and Cisplatinum in the Treatment of Locally Advanced Breast Cancer PI: Judith Hurley, M.D. 3/1/98-9/1/99 Total direct costs: $75,000 Indirect costs: $25,000 Aventis Pharmaceuticals,Inc. and Amgen, Inc. Phase II Trial of Neoadjuvant Herceptin, Taxotere and Cisplatin in the Treatment of Locally Advanced and Inflammatory Breast Cancer PI: Judith Hurley, M.D. 2/1/00-2/1/03 Total direct costs: $228,750 Indirect costs: $76,250 Glaxo-Wellcome Pharmaceuticals, Inc. The Use of Vinorelbine in the Treatment of Poor Prognosis Acute Myeloid Leukemia. PI: Judith Hurley, M.D. Total direct costs: $30,000 4/1/98-10/1/00 Indirect costs: $10,000 SEQUUS Pharmaceuticals, Inc. 960 Hamilton Court Menlo Park, CA. 94025 The Feasibility of Breast Conservation after Neoadjuvant Doxil in Stage III Breast Cancer PI Judith Hurley, M.D. 3/1/96-8/1/97 Total direct costs: $22,500 Indirect costs: $7,500 Novartis Pharmaceutical Corporation 556 Morris Ave Summit, NJ 07901 A Double Blind Randomized Parallel Group Phase III Trial Comparing the Efficacy of 4 Months of Preoperative Letrozole with Preoperative Tamoxifen PI Helen Smith (Novartis) Role on Project: Collaborator 2/1/98-9/1/99 Total direct costs: $26,500 Indirect costs: $8,750 Professional Organizations: American Society of Clinical Oncology, Member 1998-present Invited Speaker Taxotere Advisory Board, Women in Oncology, August 25, 2001 Taxotere Advisory Board, Women in Oncology, March 16, 2002 Breast Cancer International Research Group, June 22, 2002 Didactic Teaching Conference, Hematology/Oncology, University of Miami, October 23, 2002 Honors and Awards: Glen Leak Memorial Fellowship in Cancer Research, SUNY, Syracuse, NY 1980 Dr. Sarah E. Howell Award from the Women’s Cancer League January 20, 2004 Vl.TEACHING Awards Received Yearly Teaching Award - Hematology/Oncology Division 1995, 1996, 1997,1998, 1999, 2002 Teaching Specialization Mechanisms of Disease Course-Instructor 1991-4 Grand Rounds Internal Medicine Department Breast Cancer for Internists 4/00 Family Practice Department A Practical Approach to Breast Cancer 9/98, 4/01 Sylvester Cancer Center Cancer in Pregnancy 10/94 Locally Advanced Breast Cancer 5/00 Resident’s Rounds- Oncologic Emergencies 8/00, 8/02, 8/03, 8/04 Teaching Attending, Division of Hematology/Oncology, 1991-present Ward Attending on WW12 Director and Attending JMH Oncology Clinic Consultant- Breast Health Center, Jackson Memorial Hospital VII. SERVICE 2000-present Pharmacy and Therapeutics Committee- Chemotherapy Committee, Jackson Memorial Hospital 2000-2002 American Cancer Society, Florida Division, Colorectal Cancer Subcommittee, Member. 1995-97 Educational Task Force, Jackson Memorial Hospital, Chairman. 1995-97 Ambulatory Quality Improvement Council, Jackson Memorial Hospital, Member .