Download Publications/Patents: Unnatural polymerase substrates that can

Publications/Patents:
1. Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded
nucleic acids from a nucleic acid template and methods of use (2011) Jer-Kang Chen,
Boli Huang, Paul Kenney, Shoeb I. Khan, Joseph Lam, Zhaochun Ma, Steven
Menchen, Barnett Rosenblum US8058414B2; EP2279194A1; CN102124018A
2. Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded
nucleic acids from a nucleic acid template and methods of use (2009) Steven Menchen,
Barnett Rosenblum, Paul Kenney, Shoeb I. Khan, Zhaochun Ma, Jer-Kang
Chen,
Joseph Lam, Boli Huang WO2009134469A1
3. Efficient synthesis of thymidine boranophosphoramidates conjugated with amino acids
(2007) Shoeb I. Khan and Barbara R. Shaw Nucleosides, Nucleotides and Nucleic Acids
26 621-623
4. Synthesis of 5-ethynyl-2’-deoxyuridine-5’-boranomonophosphate as a potential
thymidylate synthase inhibitor (2005) Shoeb I. Khan, Mikhail I. Dobrikov and Barbara R.
Shaw Nucleosides, Nucleotides and Nucleic Acids 24 1047-1049
5. Nucleic Acids probes and methods (2002) Mark W. Grinstaff, A. Beilstein, Shoeb I.
Khan
US0177695 Al
6. Methods of synthesis of halogen base-modified oligonucleotides and subsequent labeling
with a metal-catalyzed reaction (2001) Mark W. Grinstaff, Amy E. Beilstein, Shoeb I.
Khan US6,288,221 Bl
7. Long distance electron transfer in an oligonucleotide duplex: Observation of the electron
transfer intermediate (2000) Mark T. Tierney, Milan Sykora, Shoeb I. Khan and Mark W.
Grinstaff Journal of Physical Chemistry B 104 7574-7576
8. Solid phase synthesis and photophysical properties of DNA labeled at the nucleobase
with Ru(bpy)2 (4-m-4’-pa-bpy)2+ (1999) Shoeb I. Khan, Amy E. Beilstein, Mark Tierney,
Milan Sykora, and Mark W. Grinstaff Inorganic Chemistry 38 5999-6002
9. Automated Solid-Phase DNA Synthesis and Photophysical Properties of
Oligonucleotides Labeled at the 5'-Terminus with Ru(bpy)32+ (1999) Shoeb I. Khan, Amy
E. Beilstein, Milan Sykora, Gregory D. Smith, Xi Hu and Mark W. Grinstaff Inorganic
Chemistry 38 3922-3925
10. Synthesis and Excited-State Properties of a Novel Ruthenium Nucleoside: Ru(bpy)2(4-m4'-pa-bpy-2'-deoxyuridine)2+ (1999) Shoeb I. Khan, Amy E. Beilstein, Gregory D. Smith,
Milan Sykora, and Mark W. Grinstaff, Inorganic Chemistry 38 2411-2415
11. Automated Solid-Phase Synthesis of Site Specifically Labeled Ruthenium
Oligonucleotides (1999) Shoeb I. Khan, Amy E. Beilstein, and Mark W. Grinstaff
Inorganic Chemistry 38 418-419
12. Automated Solid-Phase Synthesis of Photophysical Properties of oligonucleotides
Labeled with Metal Diimine (1999) Complexes Mark W. Grinstaff, Amy E. Beilstein, Xi
Hu, Mark T. Tierney, Gregory D. Smith, Milan Sykora, Shoeb I. Khan Journal of
Inorganic Biochemistry 74 149
13. Palladium(0) Catalyzed Modification of Oligonucleotides during Automated Solid-Phase
Synthesis (1999) Shoeb I. Khan and Mark W. Grinstaff Journal of the American
Chemical Society 121 4704-4705
14. The Alkylation of Iodouridine by a Heterogeneous Palladium Catalyst (1999) Shoeb I.
Khan and Mark W. Grinstaff Journal of Organic Chemistry 64 1077-1078
15. A Facile and Convenient Solid-Phase Procedure for Synthesizing Nucleoside
Hydroxamic Acids (1998) Shoeb I. Khan and Mark W. Grinstaff Tetrahedron Letters 39
8031-8034
16. Attenuation of alcohol induced hypothermia by cyclo (His-Pro) and its analogs (1995) J.
Carlton, Shoeb I. Khan, W. Haq, H. Mizuma, F.A. Ragan, K.B. Mathur, R. Shukla, R.C.
Srimal and C. Prasad Neuropeptides 28 351-55
17. Synthesis and antifungal activity of 3’-deoxyribonucleosides (1994) A. Kumar, Shoeb I.
Khan, A. Manglani, Z.K. Khan and S.B. Katti Nucleosides Nucleotides and Nucleic
Acids 13(5) 1049-58
18. Synthesis of 9-[5’-deoxy-5’-(alkylthio)-xylofuranosyl]adenosine and their antiviral
activity (1991) Shoeb I. Khan, D. Gulati, A.Mishra, R. Pratap and D.S. Bhakuni Indian
Journal of heterocyclic Chemistry 11 103-108
19. A process for the synthesis of 3’,5’-anhydro-9-D-xylofuranosyladenine showing antiviral
activity (1991) Shoeb I. Khan, C.X. George, R.Pratap and D.S. Bhakuni 1109/DEL/91
20. Studies on nucleosides-Synthesis of alicyclic and cyclic nucleosides of 4(5H)-oxypyrazolo[3,4-d]pyrimidine
and
4-aminopyrazolo[3,4-d]pyrimidine
and
their
antileishmanial activity (1990) Shoeb I. Khan, A. Mishra, P.Y. Guru, R. Pratap and D.S.
Bhakuni Indian Journal of Chemistry B 29B 40-46
Oral Presentations:
1. Efficient synthesis of nucleoside boranophosphoramidates conjugated with amino acids.
Shoeb I. Khan and Barbara R. Shaw,
Conference: Roundtable International conference on Nucleosides, Nucleotides and
Nucleic Acids, Bern, Switzerland, Sept 3, 2006.
2. New synthetic approach towards the synthesis of boranophosphate nucleosides, Shoeb I.
Khan, B. R. Shaw,
Conference: Nucleosides & nucleotides local chapter at Chicago, USA, Sept. 3, 2005.
3. Synthesis of 5-fluoropropynyl-2’-deoxyuridine nucleoside and boranonucleotide as
potential thymidylate synthase inhibitors, Shoeb I. Khan and B. R. Shaw,
Conference: 118th North Carolina Section, USA, ACS conference, April 2004.
4. Automated Solid-Phase Synthesis of Metallo-Oligonucleotides. Mark W.Grinstaff and
Sheob I. Khan,
Conference: 216 American Chemical Society Conference, Boston, MA, 1998.
5. Synthesis and Characterization of a Ruthenium-Labeled Amino-Nucleoside. Shoeb I.
Khan, and Mark W. Grinstaff,
Conference: Southeastern Regional Meeting of the American Chemical Society, Research
Triangle Park, NC, SERMACS-ABS #258, 1998.
6. Automated Solid-Phase Synthesis of Ruthenium-Oligonucleotides. Sheob I. Khan, Amy
E.
Beilstein, and Mark W. Grinstaff,
Conference: Southeastern Regional Meeting of the American Chemical Society, Research
Triangle Park, NC, SERMACS-ABS #257, 1998.
Poster Presentations:
1. Efficient synthesis of nucleoside boranophosphoramidates conjugated with amino acids.
Shoeb I. Khan and Barbara R. Shaw,
International Conference: Roundtable International conference on Nucleosides,
Nucleotides and Nucleic Acids, Bern, Switzerland, Sept 3, 2006.
2. New synthetic approach towards the synthesis of boranophosphate nucleosides, Shoeb I.
Khan, B. R. Shaw,
National Conference: Nucleosides & nucleotides local chapter at Chicago, Sept. 3, 2005.
3. Synthesis of nucleoside amino acid boranophosphoramidates a new class of promising
prodrugs, Shoeb I. Khan, B. R. Shaw,
International Conference: 230th American Chemical Society Conference, Washingon DC,
Aug 28, 2005.
4. Synthesis of 5-fluoro-2’-deoxyuridine-5’-boranophosphate analogs as potential prodrug
inhibitors of thymidylate synthase, Shoeb I. Khan, M. I. Dobrikov and B. R. Shaw,
National Conference: 56th Southeast Regional Meeting, Nov. 10, 2004.
5. Synthesis of 5-ethynyl-2’-deoxyuridine boranomonophosphates as potential thymidylate
synthase inhibitors, Shoeb I. Khan, M. I. Dobrikov and B. R. Shaw,
International Conference: International roundtable conference IS3NA, Minneapolis, MN,
Sept. 12, 2004.
6. Synthesis of 5-fluoropropynyl-2’-deoxyuridine nucleoside and boranonucleotide as
potential thymidylate synthase inhibitors, Shoeb I. Khan, M. I. Dobrikov and B. R. Shaw,
International Conference: 118th North Carolina Section ACS conference, April 2004.
7. Ru(diimine)3 2+ and Phenothiazine Chromophores for DNA Mediated Electron-Transfer
Studies. Mark W. Grinstaff, Amy E. Beilstein, Xi Hu, Richard A. Palmer, Shoeb I. Khan,
Gregory D. Smith, Milan Sykora, Mark T. Tierney, and Yuri V. Ilichev,
International Conference: 223rd American Chemical Society, Professor T. J. Meyer Poster
Session, Orlando, FL, 2002. ACS-ABS-INORG #129.
8. Palladium(0) Catalyzed Modification of Oligonucleotide During Automated Solid-Phase
Synthesis. Shoeb I. Khan and Mark W. Grinstaff,
International Conference: 220th American Chemical Society, Washington, DC, 2000.
ACS-ABS-ORG #067.
9. Solid-Phase Synthesis and Photophysical Properties of DNA Labeled at the Nucleobase
with a Ruthenium(II) Tris-Diimine Complex. Shoeb I. Khan, Amy E. Beilstein, Mark T.
Tierney, Mylan Sykora, and Mark W. Grinstaff,
International Conference: 220th American Chemical Society, Washington, DC, 2000.
ACS-ABS-IC #131.
10. Incorporation of Probes During Automated Solid-Phase Synthesis Using a Pd(0) Cross
Coupling Reaction. Shoeb I. Khan and Mark W. Grinstaff,
International Conference: International Symposium on Trends in Medicinal Chemistry
and Biocatalysis, 2000, New Delhi, India.
11. Automated Solid-Phase Synthesis of 5'-Terminal Labeled Metallo-Oligonucleotides.
Shoeb I. Khan and Mark W. Grinstaff,
International Conference: 218th American Chemical Society, New Orleans,
LA, 1999.
ACS-ABS-IC #400.
12. Synthesis and Excited State Properties of Novel Ruthenium Nucleosides. Amy E.
Beilstein, Shoeb I. Khan, Gregory D. Smith, Milan Sykora, and Mark W. Grinstaff,
International Conference: 218th American Chemical Society, New Orleans, LA, 1999.
ACS-ABS-IC #398.
13. Synthesis and Excited State Properties of Novel Ruthenium Nucleosides and
Oligonucleotides. Amy E. Beilstein, Shoeb I. Khan, and Mark W. Grinstaff,
International Conference: International Conference on Photochemistry, Durham, NC,
1999, PS-146.
14. Automated Solid-Phase Synthesis and Photophysical Properties of Oligonucleotides
Labeled with Metal Diimine Complexes. Mark W.Grinstaff, Amy E. Beilstein, Xi Hu,
Mark T. Tierney, Gregory D. Smith, Milan Sykora, and Shoeb I. Khan,
International Conference: International Conference on Bioinorganic Chemistry,
Minneapolis, MN, 1999.
15. Automated Solid-Phase Synthesis of Oligonucleotides Labeled with Transition Metals.
Mark W. Grinstaff, Amy E. Beilstein, Xi Hu, Gregory D. Smith, Milan Sykora, and
Shoeb I. Khan,
National Conference: Metals in Biology Gordon Conference, Venture, CA, 1999, ABS
#41.
16. The Solid Phase Synthesis of Nucleoside Hydroxamic Acids for Metal Binding. Shoeb I.
Khan and Mark W. Grinstaff,
National Conference: Southeastern Regional Meeting of the American Chemical Society,
Research Triangle Park, NC, 1998. SERMACS-ABS, # 300.
17. Automated Solid-Phase Synthesis of Metallo-Oligonucleotides. Shoeb I. Khan, Amy E.
Beilstein, Xi Hu, Shamsa Sarwar, and Mark W. Grinstaff,
International Conference: 33rd International Conference on Coordination Chemistry,
Florence, Italy, 1998. ABS #256T.
18. Synthesis and Photophysical Properties of a Ruthenium-Modified 2'-Deoxyuridine
Phosphoramidite. Shoeb I. Khan, Amy Beilstein, and Mark W. Grinstaff,
International Conference: 216th American Chemical Society, Boston, MA, 1998. ACSABS-IC #434.
19. Synthesis and Characterization of Tris-Phenanthroline Rhodium(III)-Labeled 2'deoxyadenosine. Shamsa Sarwar, Mark T. Tierney, Shoeb I. Khan, and Mark W. Grinstaff,
International Conference: 216th American Chemical Society, Boston, MA, 1998. ACS-ABSIC #432.
20. Synthesis and Characterization of a Ruthenium-Labeled Amino-Nucleoside. Xi Hu,
Shoeb I. Khan, and Mark W. Grinstaff,
International Conference: 216th American Chemical Society, Boston, MA, 1998. ACS-ABSIC #429.
21. Synthesis of Carbohydrate Metalloprotease Inhibitors. Geoffrey Hird, Matthew Sheehy,
Shoeb I. Khan, Erica Beckham, and Mark W. Grinstaff,
International Conference: 216th American Chemical Society, Boston, MA, 1998. ACS-ABSIC #428.
22. The Solid Phase Synthesis of Nucleoside Hydroxamic Acids for Metal Binding. Shoeb I.
Khan and Mark W. Grinstaff,
International Conference: 216th American Chemical Society, Boston, MA, 1998. ACS-ABSIC #427.
23. The Alkylation of Iodouridine by a Heterogeneous Catalyst. Shoeb I. Khan and Mark W.
Grinstaff,
International Conference: 216th American Chemical Society, Boston, MA, 1998. ACS-ABSORG #448.
24. Automated Solid-Phase Synthesis of Metallo-Oligonucleotides. Mark W. Grinstaff, Amy
E. Beilstein, and Shoeb I. Khan,
National Conference: Nanotechnology for the Soldier System Conference, Boston, MA, 1998.
25. Synthesis of Carbohydrate Metalloprotease Inhibitors as Potential Antibacterial Agents.
Shoeb I. Khan, Geoffrey Hird, Erica Beckham, and Mark W. Grinstaff,
International Conference: 215th American Chemical Society, Dallas, TX, 1998. ACS-ABS-IC
#138.