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Transcript
Dissecting the Transmission Biology of
Vector-Borne
Diseases
Faculty Cluster Hire Initiative:
Environmental Health Cluster
11.12.14
Derrick Mathias, PhD, MPH
Department of Entomology & Plant Pathology
College of Agriculture
Auburn University
Components of Vector-Borne Disease Systems
Vector
Host
- Immune response
- Exposure
• behavior
• vector attraction
- Nutritional status
TransmissionCycle Variables
- Competency
- Feeding behavior
- Oviposition behavior
- Biology of immature stages
Ecological
Factors
Nidus of
pathogen
transmission
- Host number
- Reservoirs
- Bridge vectors
- Vertical transmission
Reisen 2010, Annu Rev Entomol 55:461-83
Pathogen
- Virulence
- Mutation rate
- Incubation period
- Immune avoidance
- Seasonal/spatial variation in
temperature, rainfall, etc.
- Land cover, vegetation
- Landscape modification
- Climate change
Research Interests
Transmission Biology of malaria and arboviral diseases
(bluetongue, epizootic hemorrhagic disease):
Fertilization
MG invasion
Exflagellation
I.
Vector Competence
− mechanisms of pathogen invasion
• ligand variation on vector tissues
II.
Vector-Pathogen Coevolution
– population genetics/genomics of
vector & pathogen
– virus adaptation to the vector(s)
Roy et al. 2009
Sporogony
Schmidtmann, USDA-ARS
Bethan et al. 2009
Transmission
III. Vector Ecology
– feeding behavior & host attraction
(olfactory cues)
– oviposition behavior
Zieler et al., 2000 J Exp Biol 203:1599-1611
– larval ecology
– vector habitat characterization
Recent HD Mortality in wild ruminants
2007
2012
Data compiled by the Southeastern Cooperative Wildlife Disease Study, UGA
Potential Areas for
Collaboration
– Modeling of disease risk
– Objective:
To improve understanding of
transmission cycles and
conditions that lead to outbreaks.
– Variables:
• vector (density, diversity)
• pathogen (serotype, genetic
variation)
• climate
• water quantity/quality
• other abiotic factors
• land cover/use
– Potential Funding:
NSF Ecology & Evolution of
Infectious Diseases program