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CURRICULUM VITAE
Lawrence B. Cohen
Born:
Indianapolis, IN; June 18, l939
Phone and e-mail
+1 (203) 435-5892; [email protected]
Current Positions:
Professor, Department of Physiology
Yale University School of Medicine
333 Cedar St., New Haven, CT 06510 USA
Principal Scientist, Center for Functional Connectomics
Korea Institute of Science and Technology,
Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea
Education, Training, and Experience:
1961
B.A. (with honors), Biochemistry major, University of Chicago, Chicago, IL
1965
Ph.D., Department of Zoology, Columbia University, New York. Thesis: "Globular
actin: Physical characterization of G-ADP actin and comparison with G-ATP actin."
Sponsors: Eloise E. Clark and Teru Hayashi.
1962-1966
Five summers at the Marine Biological Laboratory, Woods Hole, MA. Three
with Kensal E. Van Holde (physical biochemistry of hemocyanins), one in
the Training Program in Neurophysiology (Steven W. Kuffler, director).
1966-1968
National Science Foundation Postdoctoral Fellow, with Richard D. Keynes, FRS,
Institute of Animal Physiology, Babraham, Cambridge, England.
1968-present Department of Physiology, Yale University School of Medicine.
2011-present Center for Functional Connectomics, Korea Institute of Science and Technology.
Honors:
1965 McMaster Award for Excellence in Teaching, Columbia University
1984 Naito Foundation Travel Award
1987 Elizabeth Roberts Cole Award of the Biophysical Society
1990 Fellow, American Association for the Advancement of Science
1993 Fellow, Connecticut Academy of Arts and Sciences
1998 Joseph Erlanger Distinguished Lecturer, American Physiological Society
2000 Grass Foundation Traveling Lecturer
2007 Issekutz Lecturer, Dalhousie University
2009 Cairn Lecturer, Nottingham University
2010 Q. R. Murphy Lecture, University of Wisconsin
2013 Editorial board, PLOS ONE
2014 pp 114-116 in Pioneers of Neurobiology: My Brilliant Eccentric Heroes by J.G. Nicholls.
2015 Neurophotonics Volume 2, Number 2
Students and Fellows:
I have collaborated with two predoctoral students, 21 post-doctoral fellows, and three senior
visitors. The present situation of 12 of these is:
H. Vicencio Davila Professor and Chairman Emeritus, Department of Physiology
Universidad de Los Andes, Venezuela
Brian M. Salzberg Professor of Neuroscience, University of Pennsylvania School of Medicine
William N. Ross
Professor of Physiology, New York Medical College
Amiram Grinvald
Professor and Chairman Emiritus, Department of Neurobiology
Weizmann Institute of Science, Israel
Kohtaro Kamino
Professor Emeritus of Physiology, Tokyo Medical and Dental University
Martine Cattarelli Charge de Recherche Emeritus, CNRS, Dijon,
Harry Orbach
Reader, Dept. of Vision Sciences, Glasgow Caledonian University
Jian-young Wu
Professor of Physiology and Biophysics, Georgetown University
Dejan Zecevic
Institute for Biological Research and University of Belgrade,
Yugoslavia, Professor of Biology. Because of the difficult scientific
environment in Belgrade, Dr. Zecevic returned to Yale in 1993
Michal Zochowski Associate Professor of Biophysics, University of Michigan
Matt Wachowiak
Associate University Professor, University of Utah
Bradley Baker
Principal Scientist, CFC, Korea Institute of Science and Technology,
Professional Societies:
Society of General Physiologists (councilor 1972-1974)
Biophysical Society (councilor 1975-1978)
Society for Neuroscience
Optical Society of America
Administrative and Other:
Director of Graduate Studies, Department of Physiology, Yale University, 1975-1980.
Program Director, Integrative Biology Training Grant, 1975-1980.
Organizer, Nahum Memorial Lecture, Department of Physiology, 1981-2000.
Program Director, Molecular and Cellular Neurobiology Training Grant, 1988-1994.
Organizer, Monday evening seminars, Marine Biological Laboratory, 1988-2003.
Co-organizer, Department of Physiology retreat, 1989-2000.
Member, Executive Committee, Yale Interdepartmental Neuroscience Program, 1992-2012.
Chairman, Buildings and Grounds Committee, Marine Biological Laboratory, 1997-2000;
member, 1973-2011
Co-founder and organizer, NeuroImaging Cluster, Marine Biological Laboratory, 2002-present.
Member, Whitman Advisory Committee, Marine Biological Laboratory, 2009-2013
Non-Academic Positions:
Member, RedShirtImaging, LLC, Decatur, GA
RESEARCH PUBLICATIONS:
(Since 1977, I have, where possible, avoided first and last authorships.)
Cohen, L.B. and K.E. Van Holde. (1964). Physical studies on hemocyanin. II. A comparison of the
hemocyanin and apohemocyanin of Loligo paelii. Biochemistry, 3, 1809-1813.
Grant, R.J., L.B. Cohen, E.E. Clark, and T. Hayashi. (1964). A low viscosity G-Actin preparation. Biochem
Biophys Res Comm, 16, 314-318.
Van Holde, K.E. and L.B. Cohen. (1964). Physical studies on Hemocyanin. I. Characterization and subunit
structure of Loligo paelii hemocyanin. Biochemistry, 3, 1803-1808.
Cohen, L.B. (1966). Viscosity of G-ADP and G-ATP actin. Arch Biochem Biophys, 117, 289-295.
Cohen, L.B., R.D. Keynes, and B. Hille. (1968). Light scattering and birefringence changes during nerve
activity. Nature, 218, 438-441.
Cohen, L.B., B. Hille, and R.D. Keynes. (1969). Light scattering and birefringence changes during activity
in the electric organ of Electrophorus electricus. J. Physiol (Lond), 203, 489-509.
Cohen, L.B., B. Hille, and R.D. Keynes. (1970). Changes in axon birefringence during the action potential.
J. Physiol (Lond), 211, 495-515.
Cohen, L.B. and R.D. Keynes. (1971). Changes in light scattering associated with the action potential in
crab nerves. J. Physiol (Lond), 212, 259-275.
Cohen, L.B., B. Hille, R.D. Keynes, D. Landowne, and E. Rojas. (1971). Analysis of the potentialdependent changes in optical retardation in the squid giant axon. J. Physiol (Lond), 218, 205-237.
Cohen, L.B., R.D. Keynes, and D. Landowne. (1972). Changes in light scattering that accompany the
action potential in squid giant axons: potential-dependent components. J Physiol (Lond), 224, 701-725.
Cohen, L.B., R.D. Keynes, and D. Landowne. (1972). Changes in axon light scattering that accompany the
action potential: Current-dependent components. J. Physiol. (Lond), 224, 727-752.
Davila, H.V., B.M. Salzberg, L.B. Cohen, and A.S. Waggoner. (1973). A large change in axon fluorescence
that provides a promising method for measuring membrane potential. Nature, New Biol., 241, 159-160.
Salzberg, B.M., H.V. Davila, and L.B. Cohen. (1973). Optical recording of impulses in individual neurones
of an invertebrate central nervous system. Nature, 246, 508-509.
Cohen, L.B. and D. Landowne. (1974). The temperature dependence of the movement of sodium ions
associated with nerve impulses. J. Physiol. (Lond), 236, 95-111.
Cohen, L.B., B.M. Salzberg, H.V. Davila, W.N. Ross, D. Landowne, A.S. Waggoner, and C.H. Wang.
(1974). Changes in axon fluorescence during activity: molecular probes of membrane potential. J. Membr.
Biol, 19, 1-36.
Davila, H.V., L.B. Cohen, B.M. Salzberg, and B.B. Shrivastav. (1974). Changes in ANS and TNS
fluorescence in giant axons from Loligo. J. Membr. Biol, 15, 29-46.
Ross, W.N., B.M. Salzberg, L.B. Cohen, and H.V. Davila. (1974). A large change in dye absorption during
the action potential. Biophys. J., 14, 983-986.
Brown, J.E., L.B. Cohen, P. De Weer, L.H. Pinto, W.N. Ross, and B.M. Salzberg. (1975). Rapid changes in
intracellular free calcium concentration. Detection by metallochromic indicator dyes in squid giant axon.
Biophys. J., 15, 1155-1160.
Grinvald, A., B.M. Salzberg, and L.B. Cohen. (1977). Simultaneous recording from several neurones in an
invertebrate central nervous system. Nature, 268, 140-142.
Ross, W.N., B.M. Salzberg, L.B. Cohen, A. Grinvald, H.V. Davila, A.S. Waggoner, and C.H. Wang. (1977).
Changes in absorption, fluorescence, dichroism, and birefringence in stained giant axons : optical
measurement of membrane potential. J. Membr. Biol., 33, 141-183.
Salzberg, B.M., A. Grinvald, L.B. Cohen, H.V. Davila, and W.N. Ross. (1977). Optical recording of
neuronal activity in an invertebrate central nervous system: simultaneous monitoring of several neurons. J.
Neurophysiology, 40, 1281-1291.
Grinvald, A., L.B. Cohen, S. Lesher, and M.B. Boyle. (1981). Simultaneous optical monitoring of activity of
many neurons in invertebrate ganglia using a 124-element photodiode array. J. Neurophysiology, 45, 829840.
Gupta, R.K., B.M. Salzberg, A. Grinvald, L.B. Cohen, K. Kamino, S. Lesher, M.B. Boyle, A.S. Waggoner,
and C.H. Wang. (1981). Improvements in optical methods for measuring rapid changes in membrane
potential. J. Membr. Biol., 58, 123-137.
Boyle, M.B., L.B. Cohen, E.R. Macagno, and H.S. Orbach. (1983). The number and size of neurons in the
CNS of gastropod molluscs and their suitability for optical recording of activity. Brain Research, 266, 305317.
Orbach, H.S. and L.B. Cohen. (1983). Optical monitoring of activity from many areas of the in vitro and in
vivo salamander olfactory bulb: a new method for studying functional organization in the vertebrate central
nervous system. J. Neuroscience, 3, 2251-2262.
Loew, L.M., L.B. Cohen, B.M. Salzberg, A.L. Obaid, and F. Bezanilla. (1985). Charge-shift probes of
membrane potential. Characterization of aminostyrylpyridinium dyes on the squid giant axon. Biophys. J.,
47, 71-77.
Orbach, H.S., L.B. Cohen, and A. Grinvald. (1985). Optical mapping of electrical activity in rat
somatosensory and visual cortex. J. Neuroscience, 5, 1886-1895.
Kauer, J.S., D.M. Senseman, and L.B. Cohen. (1987). Odor elicited activity monitored simultaneously from
124 regions of the salamander olfactory bulb using a voltage sensitive dye. Brain Research, 418, 255-261.
London, J.A., D. Zecevic, and L.B. Cohen. (1987). Simultaneous optical recording of activity from many
neurons during feeding in Navanax. J. Neuroscience, 7, 649-661.
Shrager, P., S.Y. Chiu, J.M. Ritchie, D. Zecevic, and L.B. Cohen. (1987). Optical measurement of
propagation in normal and demyelinated frog nerve. Biophys. J., 51, 351-355.
Cattarelli, M. and L.B. Cohen. (1989). Optical recording of the pyriform cortex activity induced by lateral
olfactory tract stimulation. Chemical Senses, 14, 577-586.
London, J.A., L.B. Cohen, and J.Y. Wu. (1989). The spread of epileptiform discharges in the
somatosensory cortex of the rat measured with voltage sensitive dyes. J. Neuroscience, 9, 2182-2190.
Zecevic, D., J.Y. Wu, L.B. Cohen, J.A. London, H.P. Hopp, and C.X. Falk. (1989). Hundreds of neurons in
the Aplysia abdominal ganglion are active during the gill-withdrawal reflex. J. Neuroscience, 9, 3681-3689.
Morton, D.W., H.J. Chiel, L.B. Cohen, and J.Y. Wu. (1991). Optical methods can be utilized to map the
location and activity of putative motor neurons and interneurons during rhythmic patterns of activity in the
buccal ganglion of Aplysia. Brain Research, 564, 45-55.
Loew, L.M., L.B. Cohen, J. Dix, E.N. Fluhler, V. Montana, G. Salama, and J.Y. Wu. (1992). A napthyl
analog of the aminostyryl pyridinium class of potentiometric membrane dyes shows consistent sensitivity in
a variety of tissue, cell, and model membrane preparations. J. Memb. Biology, 130, 1-10.
Falk, C.X., Wu Jy, L.B. Cohen, and C. Tang. (1993). Non-uniform expression of habituation in the activity
of distinct classes of neurons in the Aplysia abdominal ganglion. J. Neuroscience, 13, 4072-4081.
Tsau, Y., J.Y. Wu, H.P. Hopp, L.B. Cohen, D. Schiminovich, and C.X. Falk. (1994). Distributed aspects of
the response to siphon touch in Aplysia: spread of stimulus information and cross correlation analysis. J.
Neuroscience, 14, 4167-4184.
Wu, J.Y., L.B. Cohen, and C.X. Falk. (1994). Neuronal activity during different behaviors suggests a
distributed neuronal organization in the Aplysia abdominal ganglion. Science, 263, 820-823.
Wu, J.Y., Y. Tsau, H.P. Hopp, L.B. Cohen, A.C. Tang, and C.X. Falk. (1994). Consistency in nervous
systems: Trial-to-trial and animal-to-animal variations in the response to repeated application of a sensory
stimulus in Aplysia. J. Neuroscience, 14, 1366-1384.
Hopp, H.P., C.X. Falk, L.B. Cohen, J.Y. Wu, and A.I. Cohen. (1996). Effect of feedback from peripheral
movements on the neuron activity in the Aplysia abdominal ganglion. European J. Neuroscience, 8, 18651872.
Tsau, Y., P. Wenner, M.J. O'Donovan, L.B. Cohen, L.M. Loew, and J.P. Wuskell. (1996). Dye screening
and signal-to-noise ratio for retrogradely transported voltage-sensitive dyes. J. Neuroscience Methods, 70,
121-129.
Wenner, P., Y. Tsau, L.B. Cohen, M.J. O'Donovan, and Y. Dan. (1996). Voltage sensitive dye recording
using retrogradely transported dye in the chicken spinal cord: staining and signal characteristics. J.
Neuroscience Methods, 70, 111-120.
Hickie, C., L.B. Cohen, and P.M. Balaban. (1997). The synapse between LE sensory neurons and gill
motoneurons makes only a small contribution to the Aplysia gill-withdrawal reflex., European J.
Neuroscience, 9, 627-636.
Prechtl, J.C., L.B. Cohen, B. Peseran, P.P. Mitra, and D. Kleinfeld. (1997) Visual stimuli induce waves of
electrical activity in turtle cortex. Proc. Nat. Acad. Sci. (USA), 94, 7621-7626.
Wachowiak, M., and Cohen, L. B. (1998) Presynaptic afferent inhibition of lobster olfactory receptor cells:
Reduced action potential propagation into axon terminals. J. Neurophysiology, 80, 1011-1015.
Wachowiak, M., and Cohen, L. B., (1999), Presynaptic inhibition of primary olfactory afferents mediated by
different mechanisms in the lobster and turtle. J. Neuroscience, 19, 8808-8817.
Lam, Y-w.,, Cohen, L.B., Wachowiak, M., and Zochowski, M.R. (2000), Odors elicit three different
oscillations in the turtle olfactory bulb. J. Neuroscience, 20:749-762.
Zochowski, M., L.B. Cohen, G. Fuhrmann, and D. Kleinfeld (2000), Distributed and partially separate pools
of neurons are correlated with two different components of the gill withdrawal reflex in Aplysia. J.
Neuroscience, 20: 8485-8492.
Wachowiak, M., M. Zochowski, L.B. Cohen, and C. X. Falk (2000), The spatial representation of odors by
olfactory receptor neuron input to the Olfactory bulb is concentration invariant. Biological Bulletin, 199: 162163.
Wachowiak, M and Cohen L.B., (2001) . Representation of odorants by receptor neuron input to the mouse
olfactory bulb. Neuron, 32: 723-735.
Wachowiak, M, Cohen L.B, and Zochowski, M. (2002) Distributed and concentration invariant spatial
representations of odorants by receptor neuron input to the turtle olfactory bulb. J. Neurophysiology, 87:
1035-1045.
Wachowiak, M, and Cohen, L.B. (2003) Correspondence between odorant-evoked patterns of receptor
neuron input and intrinsic optical signals in the mouse olfactory bulb. J. Neurophysiology, 89: 1623-1639.
Lam, Y-w, Cohen, L.B., and Michal R. Zochowski, M.R. (2003), Effect of odorant quality on the three
oscillations and the DC signal in the turtle olfactory bulb. European J. Neuroscience, 17: 436-446.
Zochowski, M. R., and Cohen, L. B. (2005), Oscillations in the olfactory bulb carry information about the
history of odorant presentation. J. Neurophysiology, 94: 2667-2675.
Wuskell, J.P., Wei, M-w., Boudreaux, D., Jin, L., Engl, R., Chebolu, R., Bullen, A., Hoffacker, K.D., Kerimo,
J., Cohen, L.B., Zochowski, M.R., and Loew, L.M. (2006) Synthesis, spectra, delivery and potentiometric
responses of new styryl dyes with extended spectral ranges. J. Neuroscience Methods, 151: 200-215.
Eugenin, J., Nicholls, J. G., Cohen, L.B., and Muller K., (2006), Optical recording from respiratory pattern
generator of foetal mouse brainstem reveals a distributed network. Neuroscience, 137: 1221-1227.
Spors, H., Wachowiak, M., Cohen, L.B., and Friedrich, R.W. (2006) Spatio-temporal dynamics of receptor
neuron input to the mammalian olfactory bulb. J. Neuroscience, 26: 1247-1259
Vučinić, D., Cohen, L.B., and Kosmidis, E.K. (2006), Presynaptic centre-surround inhibition shapes odorant
evoked input to the mouse olfactory bulb in vivo. J. Neurophysiology, 2006 95:1881-1887.
Baker, B.J., Lee, H., Pieribone, V.A., Cohen, L.B., Isacoff, E.Y., Knopfel, T., Kosmidis, E. K. (2007) Three
fluorescent protein voltage sensors exhibit low plasma membrane expression in mammalian cells. J.
Neuroscience Methods, 161: 32-38.
Dimitrov, D., He, Y., Mutoh, H., Baker, B.J., Cohen, L. Akemann, W., and Knopfel, T. (2007) Engineering
and characterization of an enhanced fluorescent protein voltage sensor. PLOS One, 2(5): e440.
PMC2775812
Homma, R., L. B. Cohen, E. K. Kosmidis and S. L. Youngentob. (2009) Perceptual stability during dramatic
changes in olfactory bulb activation maps and dramatic declines in activation amplitudes. European J.
Neuroscience, 29: 1027-1034. PMC2762425
Jin, L., Baker, B., Mealer, R., Cohen, L. B., Pieribone, V., Pralle, A., and Hughes, T., (2011) Random
insertion of split-can fluorescent protein Venus into Shaker channels yields voltage sensitive probes with
improved membrane localization in mammalian cells. J. Neuroscience Methods. 199:1-9. PMC3281265.
Baker, B. J., Jin, L., Zhou, H., Cohen, L.B., Popovic, M., Platisa, J., and Pieribone, V., (2012) Genetically
encoded voltage sensors based on the Nematostella and Dario voltage sensing phosphatases exhibit fast
kinetics, J. Neuroscience Methods, 208: 190–196. PMC3398169.
Jin, L., Han, Z., Platisa, J., Wooltorton, J.R.A., Cohen, L.B., and Pieribone, V.A., (2012) Single action
potentials and subthreshold electrical events visualized in neurons using a novel fluorescent protein voltage
sensor. Neuron, 75: 779-785. PMC3439164.
Homma, R., Y. Kovalchuk, A. Konnerth, L.B. Cohen, and O. Garaschuk. (2013) In vivo functional properties
of juxtaglomerular neurons in the mouse olfactory bulb. Frontiers in Neural Circuits, 7:23. PMC3578271.
Han, Z., L. Jin, J. Platisa, L.B. Cohen, B.J. Baker, and V.A. Pieribone, (2013) Fluorescent protein voltage
probes derived from ArcLight that respond to membrane voltage changes with fast kinetics. PLoS One
8(11):e81295. doi: 10.1371/journal.pone.0081295, PMC3842285
Han, Z., Jin, L., Chen, F., Loturco, J.J., Cohen, L.B., Bondar, A., Lazar, J., and Pieribone, V.A., (2014)
Studies on the voltage sensitivity of a genetically encoded fluorescent protein voltage probe, ArcLight. PLoS
One, 9(11):e113873. doi: 10.1371/journal.pone.0113873. PMC4242678
Kovalchuk, Y., R. Homma, Y. Liang, A. Maslyukov, M. Hermes, T. M. Thestrup, O. Griesbeck, Y. Ninkovic,
L. B. Cohen and O. Garaschuk, (2015) Rapid maturation of odorant response properties in migrating adultborn neurons of the mouse olfactory bulb. Nature Communications, 6:349, doi: 10.1038/ncomms7349.
PMID:25695931
Storace, D.A, Braubach, O.R., Jin, L., Cohen, L.B., Sung, U. (2015) Monitoring brain activity with protein
voltage and calcium sensors. Nature Scientific Reports, | 5:10212 | DO: 10.1038/srep10212
Sung, U. Sepehri-Rad, M., Jin, L., Hughes, T., Cohen, L.B. Baker, B.J. (2015) Improving signal dynamics of
fluorescent protein voltage sensors by optimizing FRET interactions. PLoS ONE, 10(11): e0141585.
doi:10.1371/journal.pone.0141585
Storace, D.A. and Cohen, L.B. (2016) A contribution of the olfactory bulb to odor perception: the inputoutput transformation. Submitted.
Braubach, O.R., Tombaz, T., Homma, R., Bozza, T., Cohen, L.B., Choi. Y., (2016) Optogenetic dissection
of the glomerular unit response reveals interglomerular lateral interactions. In preparation.
# = 68
OTHER RESEARCH PUBLICATIONS FROM THE LABORATORY:
Waggoner, A.S. and A Grinvald (1977). Mechanisms of rapid optical changes of potential sensitive dyes.
Ann. New York Academy of Sciences, 303, 217-241.
Kogan, A., W. N. Ross, D. Zecevic, and N. Lasser-Ross (1995). Optical recording from cerebellar Purkinje
cells using intracellularly injected voltage-sensitive dyes. Brain Research, 700, 235-239.
Antic S. and D. Zecevic. (1995). Optical signals from neurons with internally applied voltage-sensitive dyes.
J. Neuroscience, 15, 1392-1405.
Zecevic, D. (1996). Multiple spike initiation zones in single neurons revealed by voltage-sensitive dyes.
Nature, 381, 322-325.
Shao, X.M. and Y. Tsau. (1996). Measures and statistical tests for cross-correlation between paired
neuronal spike trains with small sample size. J. Neuroscience Methods, 70, 141-152.
Antic, S., Major G., Chen, W., Wuskel, J., Loew L., and Zecevic, D. (1997). Fast voltage-sensitive dye
recording of membrane potential changes at multiple sites on an individual nerve cell in the rat cortical slice.
Biological Bulletin, 193: 261.
Antic, S., Major, G., and Zecevic, D. (1999). Fast optical recordings of membrane potential changes from
dendrites of pyramidal neurons. J. Neurophysiology, 82: 1615-1621.
Antic S., Wuskell, J. P., Loew, L., and D. Zecevic. (2000). Functional profile of a neuron: temporal and
spatial dynamics of electrical activity in situ. J. Physiology (London) 527.1, 55-69.
Zochowski, M. (2000), Intermittent dynamical control. Physica D, 145: 181-190.
Fadool, D.A., Wachowiak, M, Brann, J.H. (2001), Patch-clamp analysis of voltage-activated and chemically
activated currents in the vomeronasal organ of Sternotherus odoratus (stinkpot/musk turtle). J Exp Biol.
204:4199-4212.
Johenning, F.W., M. Zochowski, S.J. Conway, A.B. Holmes, P. Koulen, and B.E. Ehrlich, (2002) Distinct
intracellular calcium transients in neurites and somata integrate neuronal signals. J. Neuroscience. 22,
5344-5353.
Kosmidis, E.K., Pierrefiche, O., Vibert, J.F.. (2004) Respiratory-like rhythmic activity can be produced by an
excitatory network of non-pacemaker neuron models. J Neurophysiology 92: 686-699.
Wachowiak, M., Denk, W., and Friedrich, R.W. (2004) Functional organization of sensory input to the
olfactory bulb glomerulus analyzed by two-photon calcium imaging. Proc Natl Acad Sci U S A. 101: 90979102.
Laskaris, N.A., Kosmidis, E.K., Vucinic, D., and Homma, R. (2008) Understanding and characterizing
olfactory responses: A Manifold Learning Approach Based on Optical Recordings, IEEE Engineering in
Medicine and Biology Magazine, 10.1109/EMB.2007.913555, 69-79. (PMID: 18463022)
Braubach O.R., Fine A. and Croll R.P. (2012). Distribution and functional organization of glomeruli in the
olfactory bulbs of zebrafish (Danio rerio). The Journal of Comparative Neurology 520: 2317-2339.
Braubach O.R., Miyasaka N., Koide T., Yoshihara Y., Croll R.P. and Fine A. (2013) Experience-dependent
versus experience-independent postembryonic development of distinct groups of zebrafish olfactory
glomeruli. The Journal of Neuroscience. 33: 6905-6916.
Jackson R., Braubach O.R., Bilkey J., Zhang J., Akimenko M.A., Fine A., Croll R.P. and Jonz M.G.. (2013)
Expression of sall4 in taste buds of zebrafish. Developmental Neurobiology. 73: 543-58. .
Stewart A.M., Braubach O.R., Spitsbergen J., Gerlai R. and Kalueff A.V. (2014). Zebrafish models for
translational neuroscience research: from tank to bedside. Trends in Neurosciences. 37: 264-278. doi:
10.1016/j.tins.2014.02.011
Hendi, S.H. and Sepehri Rad, M. (2014) Five dimensional Myers-Perry black holes with nonlinear
electrodynamics. Physical Review D. 90, 084051.
Braubach O.R., Fine A. and Croll R.P. (2015). Organization of the pre- and postsynaptic compartments in
differently sized zebrafish olfactory glomeruli. In preparation
ARTICLES AND REVIEWS:
Van Holde, K.E. and L.B. Cohen. (1964). The dissociation and reassociation of Loligo paelii hemocyanin.
Brookhaven Symp Biol, 17, 184-193.
Cohen, L.B. (1970). Light scattering changes during axon activity. In Permeability and Function of
Biological Membranes, L. Bolis, A. Katchalsky, R.D. Keynes, W.R. Loewenstein, and B.A. Pethica eds.,
North Holland Publishing Co, Amsterdam, 318-325.
Cohen, L.B. and D. Landowne. (1971). Optical studies of action potentials. In Physiology and Biophysics of
Excitable Membranes, W.J. Adelman ed., Van Nostrand, Reinhold, New York, 247-263.
Cohen, L.B. (1973). Changes in neuron structure during action potential propagation and synaptic
transmission. Physiol Rev, 53, 373-418.
Cohen, L.B., B.M. Salzberg, H.V. Davila, A.S. Waggoner, and C.-.H. Wang. (1974). Optical measurement
of spike activity in neurons of the leech central nervous system. Actualities Neurophysiologiques, 10, 23-30.
Cohen, L.B. and P. DeWeer. (1977). Structural and metabolic processes directly related to action potential
propagation. Handbook of Physiology: The Nervous System, 1, 137-159.
Cohen, L.B. and B.M. Salzberg. (1978). Optical measurement of membrane potential. Rev Physiol
Biochem Pharmacol, 83, 35-88.
Cohen, L.B., B.M. Salzberg, and A. Grinvald. (1978). Optical methods for monitoring neuron activity. Annu
Rev Neurosci, 1, 171-182.
Salzberg, B.M., L.B. Cohen, A. Grinvald, and W.N. Ross. (1979). Potentiometric probes for optical
recording from multiple sites in neural networks. In Frontiers in Bioenergetics, J.S. Dutton, J.S. Leigh, and
A. Scarpa eds., Academic Press, New York, 1311-1322.
Cohen, L.B. and A. Grinvald. (1981). Optical monitoring of membrane potential: Simultaneous detection of
activity in many neurons. In Advances in Physiological Sciences: Physiology of Excitable Membranes, Vol
4, Akademai Kiado, Budapest, 171-182.
Cohen, L.B. and J. Hoffman. (1982). Optical monitoring of membrane potential. In Techniques in cellular
physiology, P.F. Baker ed., Elsevier, Amsterdam, North Holland, 1-13.
Cohen, L.B., D. Landowne, L.M. Loew, and B.M. Salzberg. (1984). Optical signals : Changes in membrane
structure, monitoring membrane potential, and measuring calcium. In Current topics in membranes and
transport : The squid axon, Vol 22, P.F. Baker ed., Academic Press, New York, 423-443.
Cohen, L.B. and S. Lesher. (1986). Optical monitoring of membrane potential: methods of multisite optical
measurement. Soc Gen Physiol Ser, 40, 71-99.
Cohen, L.B., J.A. London, D. Zecevic, M. Cattarelli, and D. Schiminovich. (1986). Multi-site optical
measurement of membrane potential with high time resolution. In Image function in the nervous system :
optical methods in cellular neurobiology, B.M. Salzberg ed., Soc Neurosci Short Course 2 Syllabus,
Washington, DC , 42-61.
London, J.A., D. Zecevic, and L.B. Cohen. (1986). Simultaneous monitoring of activity of many neurons
from invertebrate ganglia using a multielement detecting system. Soc Gen Physiol Ser, 40, 115-131.
London, J.A., D. Zecevic, L.M. Loew, H.S. Orbach, and L.B. Cohen. (1986). Optical measurement of
membrane potential in simple and complex nervous systems. In Fluorescence in the biological sciences,
D.L. Taylor, A.S. Waggoner, F. Lanni, R.F. Murphy, and R. Birge eds., AR Liss, Inc, New York, 423-447.
Cohen, L.B. (1988). More light on brains. Nature; News and Views., 331, 112-113.
London, J.A., D. Zecevic, and L.B. Cohen. (1988). Simultaneous optical monitoring of action potential
activity from many neurons in invertebrate ganglia. In Spectroscopic membrane probes, L.M. Loew ed.,
CRC Press, Boca Raton, FL, 101-114.
Wu, J.Y., J.A. London, D. Zecevic, H.-.P. Hopp, L.B. Cohen, and C. Xiao. (1988). Optical monitoring of
activity of many neurons in invertebrate ganglia during behaviors. Experientia, 44, 369-376.
Cohen, L.B. (1989). Optical approaches to neuron function. Introduction. Ann Rev Physiol, 51, 487-490.
Cohen, L.B., H.P. Hopp, J.Y. Wu, C. Xiao, J. London, and D. Zecevic. (1989). Optical measurement of
neuron activity in invertebrate ganglia. Annu Rev Physiol, 51, 527-541.
Wu, J.Y., J.A. London, D. Zecevic, L.M. Loew, H.S. Orbach, M. Cattarelli, and L.B. Cohen. (1989). Optical
measurement of membrane potential in invertebrate ganglia and mammalian cortex. In Cell Structure and
Function by Microspectrofluorometry, E. Kohen and J.G. Hirschberg eds., Academic Press, San Diego, 329346.
Cohen, L.B. and J.Y. Wu. (1990). One neuron, many units? Nature, 346, 108-109.
Cohen, L.B., D. Landowne, and B.M. Salzberg. (1990). Optical measurements on squid axons. In Squid as
experimental animals., D. Gilbert, W. Adelman, and J. Arnold eds., Plenum, New York, 161-170.
Hopp, H.P., J.Y. Wu, C.X. Falk, M.G. Rioult, J.A. London, D. Zecevic, and L.B. Cohen. (1990). Multisite
optical measurement of membrane potential. In Neuromethods, Vol 14, A.A. Boulton, G.B. Baker, and C.H.
Vanderwolf eds., Humana Press, Clifton, NJ, 193-226.
Falk, C.X., H.P. Hopp, J.Y. Wu, L.B. Cohen, D.P. Zecevic, and J.A. London. (1992). An overview of the
neuronal activity in the Aplysia abdominal ganglion during the gill withdrawal reflex. In Neurobiology of
Motor Programme Selection: New Approaches to, J. Kien, C. McCrohan, and W. Winlow eds., Manchester
University Press , Manchester, 88-101.
Cohen, L.B. (1993). Optical monitoring of physiological activity: a brief history. Jap. J. Physiol., S1-S6.
Tsau, Y., C.X. Falk, L.B. Cohen, and J.Y. Wu. (1993). Multi-neuronal measurement of spike activity in
invertebrate ganglia: Complexity in a simple system. Concepts in Neuroscience, 4, 89-104.
Wu, J.Y. and L.B. Cohen. (1993). Fast multisite optical measurements of membrane potential. In
Fluorescent and Luminescent Probes for Biological Activity., W.T. Mason ed., Academic Press, London,
389-404.
Wu Jy, , C.X. Falk, L.B. Cohen, Y. Tsau, and D. Zecevic. (1993). Optical measurements of action potential
activity in invertebrate ganglia. Jap J Physiology, 43 Suppl. 1, S21-S29.
Cohen. L.B., (1995). Optical monitoring of activity in the nervous system: A brief history. Tsitologia, 37,
1136-1141.
Wu, J.Y., Lam, Y. W., Falk, C. X., Cohen, L. B., Fang, J., Loew, L., Prechtl, J.C., Kleinfeld, D., and Tsau, Y.
(1998) Voltage-Sensitive Dyes for Monitoring Multi-Neuronal Activity in the Intact CNS. Histochemical J.,
169-187.
Walters, E. T. and Cohen, L.B. (1998) Functions of the LE sensory neurons in Aplysia. Invertebrate
Neuroscience, 3, 15-25.
Ross, W.N., L.B. Cohen, and D. Zecevic. (1999). Optical Recording of Neuronal Activity. In Encyclopedia
of Neuroscience; second edition., G.. Adelman ed., Elsevier Science Publishers, Amsterdam, 1542-1544.
Wu J-Y., L. B. Cohen, and C. X. Falk, (1999), Fast multisite optical measurement of membrane potential.
With two examples. In: Fluorescent and Luminescent Probes for Biological Activity 2nd Edition, ed. by W. T.
Mason. Academic Press. 222-237
Antic, S., Chun X. Falk, L. B. Cohen, Y.W. Lam, M. Wachowiak, D. Zecevic, and M. Zochowski, (1999), Fast
Multisite Optical Measurement of Membrane Potential. Three Examples. FASEB Journal, 13: S271-S276.
Wu, J. Y., L. B. Cohen, Y. Tsau, M. Zochowski, and C. X. Falk, (2000), Imaging with Voltage-Sensitive
Dyes: Spike Signals, Population Signals and Retrograde Transport. In: Imaging Living Cells, ed. by R.
Yuste, F. Lanni, and A. Konnerth, Cold Spring Harbor Press. 49.1-49.12.
Zochowski, M., Wachowiak, D.M., Falk, C. X., Cohen, L. B., Lam, Y.-W., Antic, S., and Zecevic, D., (2000)
Imaging membrane potential with voltage-sensitive dyes. Biological Bulletin, 198: 1-21.
Wachowiak, M., Y.-w. Lam, L. B. Cohen, and M. R. Zochowski, (2002), Voltage-sensitive and calcium
sensitive dye imaging of activity in the olfactory bulb: presynaptic inhibition, maps of receptor input, and
oscillations. In: Methods in Chemosensory Research, ed. by Drs. S. A. Simon and M. Nicolelis, CRC Press,
Boca Raton, FL. Pp. 91-115.
Wachowiak M., Cohen L.B., Ache B.W., (2002) Presynaptic inhibition of olfactory receptor neurons in
crustaceans. J Microsc. Res. Tech. 58:, 365-375.
Zecevic, D., C.X. Falk, M. Djurisic, L. B. Cohen, M. Zochowski, S. Antic, and M. Wachowiak. (2003),
Imaging Nervous System Activity with Voltage-Sensitive Dyes. In: Current Protocols in Neuroscience, ed.
by Dr. M. Rogawski. John Wiley & Sons, New York, Chapter 6, Unit 6.17.
Zochowski, M., Cohen, L. B., Falk, C. X., Wachowiak, M. (2002). The olfactory bulb: Maps of receptor
input and oscillations. In: In vivo optical imaging of brain function. ed. by R.D. Frostig, CRC Press, Boca
Raton, pp.1-19.
Wachowiak, M., Cohen, L.B., Falk, C.X., and Zochowski, M., (2002), Voltage and calcium imaging of brain
activity: Examples from the turtle and the Mouse. In "Brain Mapping: The Methods, 2nd edition", ed. by A.
W. Toga and J. C. Mazziotta, Academic Press, pp. 77-95.
Djurisic, M. R., Zochowski, M., Wachowiak, M., Falk, C.X., Cohen, L.B., and Zecevic, D. (2003) Optical
Monitoring of Neural Activity Using Voltage-Sensitive Dyes, In Methods In Enzymology, ed. by G. Marriott
and I. Parker, 361B: 423-451.
Wachowiak, M., R. Friedrich, and L. B. Cohen (2003) Olfactory coding strategies visualized by in vivo
calcium-sensitive dye imaging. Proceedings of the 25th Annual International Conference of the IEEE.
3:2239-2241.
Vucinic, D., L.B. Cohen, M. Wachowiak, and E. Kosmidis (2003) What the Nose Tells the Brain About
Odors, IEEE Engineering and Medicine and Biology, 2113-2116.
Ross, W.N., Cohen L.B. and Zecevic, D. (2004):Optical recording of neuronal activity. In: The encyclopedia
of Neuroscience, 3rd Edition (Web). Adelman G, Smith BH, Editors. Amsterdam/New York: Elsevier
Science.
Kosmidis E, Cohen LB, Falk C, Wu JY and Baker B. (2005) Imaging with Voltage-Sensitive Dyes: Spike
Signals, Population Signals, and Retrograde Transport. In: Imaging Living Cells, edited by Yuste R and
Konnerth A. New York: Cold Spring Harbor Press, 445-455.
Baker, B., Kosmidis, E., Vucinic, D., Falk, C.X., Cohen, L.B., Djurisic, M., and Zecevic, D., (2005), Imaging
Brain Activity with Voltage- and Calcium-Sensitive Dyes. Cellular and Molecular Neurobiology, 25: 245-282.
Baker, B.J., Mutoh, H., Dimitrov, D., Akemann W, Perron, A., Iwamoto, Y., Jin, L., Cohen, L.B., Isacoff, E.Y.,
Pieribone, V.A., Hughes, T. and Knöpfel, T. (2008) Genetically encoded fluorescent sensors of membrane
potential. Brain Cell Biology. 36, 53-67. PMID: 18679801, PMCID: PMC2775812.
Homma, R., Baker, B., Jin, L., Garaschuk, O., Konnerth, A., Cohen, L.B., Bleau, C.X., and Zecevic, D.
(2009) Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes. In
Dynamic imaging: Towards quantitative understanding of brain function. ed. by F. Hyder, Methods Mol Biol
489: 43-79. (PMID: 18839087)
Homma, R., Baker, B.J., Jin, L., Garaschuk, O., Konnerth, A., Cohen, L.B., and Zecevic, D. (2009) Widefield and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes. Phil. Trans. R. Soc.
B, (364): 2453-2467. PMCID: PMC2865128
Muller, K.J., Tsechpenakis, G., Homma, R., Nicholls, J. G., Cohen, L.B., Eugenin, J., (2009) Optical
Analysis of Circuitry for Respiratory Rhythm in Isolated Brainstem of Foetal Mice. Phil. Trans. R. Soc. B,
(364): 2485-2491. PMCID: PMC2865113.
Zecevic, D., Cohen, L.B., Ross, W.N. (2009), Voltage-sensitive dye. Scholarpedia 4(3):3355.
Jin, L., Baker, B.J., Cohen, L.B., Mutoh, H., Dimitrov, D., Perron, A., Iwamoto, Y., Isacoff, E.Y., Pieribone,
V.A., Hughes, T., Knöpfel, T., and Akemann, W , (2010) Fluorescent sensors of membrane potential that
are genetically encoded. In "Imaging the Brain with Optical Methods", Anna W. Roe, editor, Springer, pp
27-44.
Wu, J-y and L. B. Cohen, (2010) Now single spines: monitoring neuronal membrane potential with
submicron and submillisecond resolution. J. Physiol. (London), 588.8: 1191-1192. PMCID: PMC2872725.
Cohen, L., (2010) Historical overview and general methods of membrane potential imaging. In: The Voltage
Imaging Book ed by M. Canepari and D. Zecevic, Springer, 1-11.
Jin, L, Cohen, L.B., Hughes, T., Pieribone, V.A., Isacoff E.Y., Salzberg, B.M., and Baker B.J. (2010)
Genetically encoded protein sensors of membrane potential. In: The Voltage Imaging Book, ed. by M.
Canepari and D. Zecevic, Springer, 157-163.
Baker, B, Gao, X., Wolff, B.S., Jin, L., Cohen, L.B., Bleau, C.X. and J.-y. Wu, (2011) Imaging with VoltageSensitive Dyes: Spike Signals, Population Signals, and Retrograde Transport. in Imaging in Neuroscience,
ed. By F. Helmchen, A. Konnerth and R. Yuste, Cold Spring Harbor Laboratory Press, 471-490
Fink, S., Kovalchuk, Y., Homma, R., Schwendele, B., Direnberger, S., Cohen, L.B., Griesbeck, O., and
Garaschuk, O. (2012) In Vivo Functional Imaging of the Olfactory Bulb at Single Cell Resolution. in
Neuromethods, 67: 21-43.
Devor, A., Bandettini, P.A., Boas, D.A. Bower, J.M., Buxton, R.B., Cohen, L.B., Dale, A.M., Einevoll, G.T.
Fox, P.T., Franceschini, M.A., Friston, K.J., Fujimoto, J.G., Geyer, M.A., Greenberg, J.H., Halgren, E.,
Hämäläinen, M.S. Helmchen, F., Hyman, B.T., Jasanoff, A., Jernigan, T.L., Judd, L.L., Kim, S-G., Kleinfeld,
D., Kopell, N.J., Kutas, M., Kwong, K.K., Larkum, M.E., Lo, E.H., Magistretti, P.J., Mandeville, J.B., Masliah,
E., Mitra, P.P., Mobley, W.C., Moskowitz, M.A., Nimmerjahn, A., Reynolds, J.H., Rosen, B.R., Salzberg,
B.M., Schaffer, C.B., Silva, G.A., So, P.T.C., Spitzer, N.C., Tootell, R.B., Van Essen, D.C., Vanduffel,
W.,(2014) The Challenge of Connecting the Dots in the B.R.A.I.N., Neuron, 80: 270-274.
Braubach, O., Cohen, L.B., and Choi, Y. (2015) Historical overview and general methods of membrane
potential imaging. Adv Exp Med Biol. 859:3-26. doi: 10.1007/978-3-319-17641-3_1
Storace, D., Sepehri Rad, M., Han, Z., Jin, L., Cohen, L.B., Hughes, T., Baker, B.J., and Sung, U. (2015).
Genetically encoded protein sensors of membrane potential. Adv Exp Med Biol. 859:493-509. doi:
10.1007/978-3-319-17641-3_20.
Bradley Baker, Xin Gao, Brian S. Wolff, Lei Jin, Lawrence B. Cohen, Chun X. Bleau and J.-Y. Wu (2015)
In Vivo Voltage-Sensitive Dye Imaging of Mammalian Cortex Using ''Blue'' Dyes. Cold Spring Harb Protoc;
doi: 10.1101/pdb.prot089359
Bradley Baker, Xin Gao, Brian S. Wolff, Lei Jin, Lawrence B. Cohen, Chun X. Bleau and J.-Y. Wu (2015)
Voltage-Sensitive Dye Imaging of Population Signals in Brain Slices. Cold Spring Harb Protoc; doi:
10.1101/pdb.prot089342.
Storace, D., Sepehri Rad, M., Kang, B.E., Cohen, L.B., Hughes, T., and Baker, B.J. (2016)
Toward better genetically encoded sensors of membrane potential. TiNS, in press.
DEMONSTRATIONS:
Cohen, L.B. and R.D. Keynes. (1969). Birefringence changes during nerve activity. J Physiol (Lond), 200,
18p.
Landowne, D., L.B. Cohen, and B.B. Shrivastav. (1971). Changes in light scattering associated with
synaptic activity in the skate electric organ. J Gen Physiol, 57, 243.
Cohen, L.B., B.M. Salzberg, and H.V. Davila. (1973). Changes in fluorescence of a squid giant axon during
excitation, a demonstration. Biological Bulletin, 145, 429-430.
Boyle, M.B., L.B. Cohen, and E. Macagno. (1979). The numbers and sizes of cells in molluscan ganglia:
simultaneous optical recording of activity from many neurons. Biological Bulletin, 157, 359.
Zecevic, D., J.A. London, and L.B. Cohen. (1985). Simultaneous monitoring of activity of many neurons in
the buccal ganglia of Navanax during feeding (demonstration). J Gen Physiol, 86, 19A.
Zochowski, M., Ying-wan Lam, L. B. Cohen, and M. Wachowiak, (1999) Optical measurements of activity in
the turtle olfactory bulb using voltage-sensitive dyes: a demonstration. J. Gen. Physiol. 114, #24.
ABSTRACTS: (Selected abstracts whose results are not published in full papers are included. Not
updated.)
Grant, R.J. and L.B. Cohen. (1966). A factor affecting network formation in G-actin solutions. Fed Proc,
23, 223.
DePhillips, H.A., L.B. Cohen, and K.E. Van Holde. (1967). Oxygen-binding by specific multisubunit
hemocyanin structures. Fed Proc, 26, 275.
Cohen, L.B. and D. Landowne. (1970). Changes in light scattering during synaptic activity in the electric
organ of the skate, Raia erinacea. Biophys J, 10, 16a.
Sharnoff, M., N.J. Romer, L.B. Cohen, B.M. Salzberg, M.B. Boyle, and S. Lesher. (1978). Differential
holography of squid giant axons during excitation and rest Biol Bull, 155, 465-466.
Boyle, M.B. and L.B. Cohen. (1980). Birefringence signals that monitor membrane potential in cell bodies
of molluscan neurons. Fed Proc, 39, 2130.
Salama, G., T. Sanger, and L.B. Cohen. (1981). Optical recording of action potential propagation in intact
heart. Biological Bulletin, 161, 316.
Cohen, L.B. and J.E. Freedman. (1982). A relatively robust, single-trial associative learning in the
opisthobranch mollusc, Pleurobranchaea californica. Biological Bulletin, 163, 381.
Orbach, H.S., L.B. Cohen, and A. Grinvald. (1982). Optical monitoring of evoked activity in the visual
cortex of the marine rat. Biological Bulletin, 163, 389. (kept in the list for its title)
Roschin, V., J.Y. Wu, L.B. Cohen, C.X. Falk, and A.I. Cohen. (1990). The effect of increased divalent ion
concentration on the gill withdrawal and the neuronal activity in the abdominal ganglion of Aplysia an
attempt to restrict the neuronal substrate of the behavior. Abstracts Soc. for Neuroscience, 16, 19.
Hickie, C., P. Wenner, M. O'Donovan, Y. Tsau, J. Fang, and L.B. Cohen. (1996). Optical monitoring of
activity from individual and identified populations of neurons retrogradely labeled with voltage-sensitive
dyes. Abs Soc Neuroscience, 22, 321.
3/2016