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Curriculum Vitae: Prof. Dr. Carsten Bokemeyer Present Ranks: Director Department of Oncology, Hematology, Bone Marrow Transplantation with section Pneumology Department of Medicine University Hospital Hamburg-Eppendorf Hamburg, Germany Director University Cancer Center Hamburg University Hospital Hamburg-Eppendorf Hamburg, Germany Education: 1989 1989 1989-1995 1995-2004 M. D. / University of Hannover Medical School, Hannover, Germany FMGEMS Internal Medicine Internship / Residency University of Hannover Medical School Hannover, Germany Faculty Member Department of Internal Medicine Division of Hematology / Oncology / Immunology / Rheumatology University of Tuebingen Medical Center Tuebingen, Germany Academic Appointments: 1996 “Habilitation” (Postdoctoral lecturing qualification) Department of Internal Medicine Medical School Hannover, Germany 2000 Nominated for C3 position as Professor of Medicine at Muenster University, Germany 2000 Associate Professor of Medicine at Tuebingen University 2004 Appointed Professor of Medicine, Director of Division of Oncology / Hematology with sections Bone Marrow Transplantation and Pneumology 2007 Nominated Director University Cancer Center Hamburg Specialty Board Status: 1993 Certification – European Society for Medical Oncology 1995 Certification – German Board of Internal Medicine 1997 Certification – German Board of Internal Medicine: Hematology-Medical Oncology 2000 Certification – Quality Management in Medicine Professional Societies: 1991-present German Cancer Society (DKG) 1991-present Wilsede School of Oncology 1991-present European Society of Medical Oncology (ESMO) 1995-present American Society of Clinical Oncology (ASCO) 1995-present German Society of Hematology / Oncology (DGHO) 1998-present German Association for Bone Marrow and Blood Stem Cell Transplantation (DAGKBT) Honors /Awards: Undergraduate Member of the “Studienstiftung des deutschen Volkes” (German Academic Scholarship Fund) Award of the Ministry of Science for “Outstanding Student Achievements in Medicine” Graduate 2000 National Award of the German Cancer Society 2000 Award for Experimentel Urological Reseach German Society of Urology 2001 Award of the Baden-Wuerttembergische Cancer Society 2001 Award of the German Society for Clinical Pharmacology 2002 Scientific Award for Medical Oncology (AIO) 2006 Award of the University of Heidelberg (Anita- und Cuno-Wieland-Preis) Committees: 1997-2004 Member of the Research Advisory Committee of the University of Tuebingen 2000-2004 Founding member of the Interdisciplinary Center for GIcancer at Tuebingen University 2001-2004 Founding member of the Interdisciplinary Center for Soft Tissue Sarcomas at Tuebingen University 2002-present Chairman of the ESMO Examination Committee for Medical Oncology 2002-present Board member of the German Society for Haematology and Oncology 2005-present Board member of the German Cancer Society (DKG) 2005-present Board member of the Cancer Society of Hamburg Clinical Trials: Experience in GCP-conform conduct of clinical studies as participant and investigator for more than 15 years Publications: Editor of 10 books on oncology/supportive care Author/coauthor 87 book chapters on Oncology/Hematology/Supportive Care Author/coauthor of 329 original publications / reviews 10 most important publications 1. Schwab M, Zanger UM, Marx C, Schaeffler E, Klein K, Dippon J, Kerb R, Blievernicht J, Fischer J, Hofmann U, Bokemeyer C, Eichelbaum M: Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group. J Clin Oncol, Mar 2008 - Epub ahead of print. 2. Hartmann JT, Gauler T, Metzner B, Gerl A, Casper J, Rick O, Horger M, Schleicher J, Derigs G, Mayer-Steinacker R, Beyer J, Kuczyk MA, Bokemeyer C; German Testicular Cancer Study Group: Phase I/II study of sequential dose-intensified ifosfamide, cisplatin and etoposide plus paclitaxel as induction chemotherapy for poor prognosis germ cell tumors by the German Testicular Cancer Study Group. J Clin Oncol 25: 5742-2747, 2007. 3. Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffith D, Lee FY, Bokemeyer C, Deininger MW, Druker BJ, Heinrich MC: Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 66: 473-481, 2006. 4. Honecker F, Stoop H, de Krijger R, Lau C, Castrillon D, Oosterhuis J, Bokemeyer C, Looijenga LHJ: Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells. Am J Pathol 203:849-857, 2004. 5. Kollmannsberger C, Beyer J, Liersch R, Schoeffski P, Metzner B, Rick O, Hartmann JT, Stengele K, Hohloch K, Spott C, Kanz L, Bokemeyer C: Combination chemotherapy with gemcitabine plus oxaliplatin in patients with intensively pretreated or refractory germ cell cancer: a study of the German Testicular Cancer Study Group (GTCSG). J Clin Oncol 22:108-114, 2004. 6. Schmoll HJ, Kollmannsberger C, Metzner B, Hartmann JT, Schleucher N, Schöffski P, Schleicher J, Rick O, Beyer J, Hossfeld DK, Kanz L, Berdel WE, Andreesen R, Bokemeyer C: Long-term results of first-line sequential high-dose VIPchemotherapy plus autologous stem cell support for patients with advanced metastatic germ cell cancer: an extended phase I/II study of the german testicular study group. J Clin Oncol 21:4083-4091, 2003. 7. Bokemeyer C, Nichols C, Droz JP, Schmoll E, Horwich A, Gerl A, Fossa SD, Beyer J, Pont J, Einhorn L, Hartmann JT: Extragonadal germ cell tumors of the mediastinum and retroperitoneum - results from an international analysis. J Clin Oncol 20:1864-1873, 2002. 8. Mayer F, Gillis AJM, Dinjens W, Oosterhuis JW, Bokemeyer C, Looijenga LHJ: Microsatellite instability of germ cell tumors is associated with resistance to systemic treatment. Cancer Res 62:2758-2760, 2002. 9. C. Bokemeyer, A. J. M. Gillis, K. Pompe, F. Mayer, B. Metzner, N. Schleucher, J. schleicher, G. Pflugrad-Jauch, J. Oosterhuis, L. Kanz, and L. Looijenga. Clinical impact of germ cell tumor cells in apheresis products of patients receiving highdose chemotherapy. J Clin Oncol 19 (12):3029-3036, 2001 10. J. T. Hartmann, S. D. Fossa, C. Nichols, J. P. Droz, A. Horwich, A. Gerl, J. Beyer, J. Pont, K. Fizazi, H. Hecker, L. Kanz, L. Einhorn, and C. Bokemeyer. Incidence of metachronous testicular cancer in patients with extragonadal germ cell tumors. J Natl.Cancer Inst. 93 (22):1733-1738, 2001. 11. J. T. Hartmann, C. R. Nichols, J. P. Droz, A. Horwich, A. Gerl, S. D. Fossa, J. Beyer, J. Pont, K. Fizazi, L. Einhorn, L. Kanz, and C. Bokemeyer. Hematologic disorders associated with primary mediastinal nonseminomatous germ cell tumors. J Natl.Cancer Inst. 92 (1):54-61, 2000. 12. C. Bokemeyer, C. Kollmannsberger, C. Meisner, A. Harstrick, J. Beyer, B. Metzner, J. T. Hartmann, H. J. Schmoll, L. Einhorn, L. Kanz, and C. Nichols. Firstline high-dose chemotherapy compared with standard-dose PEB/VIP chemotherapy in patients with advanced germ cell tumors: A multivariate and matched-pair analysis. J Clin Oncol 17 (11):3450-3456, 1999. 13. C. Bokemeyer, P. Nowak, A. Haupt, B. Metzner, H. Kohne, J. T. Hartmann, L. Kanz, and H. J. Schmoll. Treatment of brain metastases in patients with testicular cancer. J Clin Oncol 15 (4):1449-1454, 1997. 14. C. Bokemeyer, C. C. Berger, M. A. Kuczyk, and H. J. Schmoll. Evaluation of longterm toxicity after chemotherapy for testicular cancer. J Clin Oncol 14 (11):2923- 2932, 1996..