Download GM Crops Pipeline

GM Crops – so what is in the pipeline?
All-Party Parliamentary Group on Science
and Technology in Agriculture
Dr Julian Little
Chair of the Agricultural Biotechnology Council
GM crops – what’s in the pipeline?
Crops
Countries
Public-Private Partnerships
Conclusions
JPL – APPG on Science & Technology in Agriculture – 24/03/09
Remember…
 The European Regulatory system is the most robust
anywhere in the world
 No GM product has achieved regulatory approval for
cultivation since 1998
 Only one “first generation” is currently licenced for use in the
EU
 We do have a functional system for import and food and
feed use
 10 products went into the system in 2008
 Only 4 products came out of the system in 2008
JPL – APPG on Science & Technology in Agriculture – 24/03/09
Industry Soybean Portfolio
Agronomic
Quality/Food
A Steady Pipeline of New Biotech Events Nearly Every Year
Omega-3
RR2Y
Omega-3
Bt/RR2Y
(Monsanto;
Steandonic Acid)
(EPA/DHA)
(Monsanto)
DuPont
Low Sat
(Monsanto)
Rust
(Monsanto)
High
Stearate
(Monsanto;
DuPont)
High BetaConglycinin
(Monsanto;
DuPont)
(Monsanto;
Pioneer
Dicamba Tolerant
(Monsanto)
LowPhytate
Feed: High Protein
Soybean
(Monsanto; DuPont)
Yield
Antibody containing
(Monsanto;
Pioneer)
(against E. coli
0157:H)
(DuPont)
201X
2009
Low Lin
Modified 7S
Protein FF
(Syngenta)
(DuPont)
High Oleic
(DuPont)
Glyphosate &
isoxazole tol.
(Bayer)*
GAT/Glyphosate-ALS
(Pioneer)
Liberty Link
(Bayer)
High Oleic, Stearate
(DuPont)
Disease
(Monsanto;
Pioneer)
Soybean Cyst
Nematode
Monsanto; Pioneer
Processing: High
Oil Soy
(Monsanto)
Herbicide tol.: 2,4-D
(Dow) and aryloxyphenoxy
propionate herbicides
JPL – APPG on Science & Technology in Agriculture – 24/03/09
*Estimated commercialization pipeline of soybean biotech events prepared by the American Soybean Association, November 2007.
Industry Soybean Portfolio – Helping Farmers to grow their crop
Agronomic
Quality/Food
A Steady Pipeline of New Biotech Events Nearly Every Year
Omega-3
(Monsanto;
Steandonic Acid)
RR2Y
Omega-3
(EPA/DHA)
DuPont
Bt/RR2Y
(Monsanto)
Low Sat
(Monsanto)
(Monsanto)
High
Stearate
(Monsanto;
DuPont)
High BetaConglycinin
(Monsanto;
DuPont)
Low-Phytate
(DuPont)
Rust
(Monsanto;
Pioneer
Dicamba Tolerant
(Monsanto)
Feed: High Protein Soybean
(Monsanto; DuPont)
Yield
(Monsanto;
Pioneer)
Antibody containing
(against E. coli
0157:H)
201X
2009
Low Lin
(Syngenta)
High Oleic
(DuPont)
Modified 7S Protein
FF (DuPont)
Glyphosate &
isoxazole tol.
High Oleic, Stearate
(DuPont)
(Bayer)*
GAT/Glyphosate-ALS
(Pioneer)
Liberty Link
(Bayer)
Disease
(Monsanto;
Pioneer)
Soybean Cyst
Nematode
Monsanto; Pioneer
Processing: High Oil
Soy
(Monsanto)
Herbicide tol.: 2,4-D
(Dow) and aryloxyphenoxy
propionate herbicides
JPL – APPG on Science & Technology in Agriculture – 24/03/09
*Estimated commercialization pipeline of soybean biotech events prepared by the American Soybean Association, November 2007.
Industry Soybean Portfolio – Food Quality & Nutrition
Agronomic
Quality/Food
A Steady Pipeline of New Biotech Events Nearly Every Year
Omega-3
RR2Y
Omega-3
Bt/RR2Y
(Monsanto)
(Monsanto;
Steandonic Acid)
(EPA/DHA)
DuPont
Low Sat
(Monsanto)
Rust
(Monsanto;
Pioneer
(Monsanto)
High
Stearate
(Monsanto;
DuPont)
High BetaConglycinin
(Monsanto;
DuPont)
LowPhytate
Dicamba Tolerant
(Monsanto)
Feed: High Protein
Soybean
Antibody containing
Yield
(Monsanto;
Pioneer)
(Monsanto; DuPont)
(against E. coli
0157:H)
(DuPont)
201X
2009
Low Lin
Modified 7S
Protein FF
(Syngenta)
(DuPont)
High Oleic
(DuPont)
GAT/Glyphosate-ALS
(Pioneer)
Liberty Link
(Bayer)
Glyphosate &
isoxazole tol.
(Bayer)*
High Oleic, Stearate
(DuPont)
Processing: High
Oil Soy
(Monsanto)
Disease
(Monsanto;
Pioneer)
Soybean Cyst Nematode
Monsanto; Pioneer
Herbicide tol.: 2,4-D
(Dow) and aryloxyphenoxy
propionate herbicides
JPL – APPG on Science & Technology in Agriculture – 24/03/09
*Estimated commercialization pipeline of soybean biotech events prepared by the American Soybean Association, November 2007.
Soybean – non agronomic traits
High oleic soybean
– Oleic acid reduces transfats
– Submitted for regulatory approval
Low phytate soybeans
– Reduced phosphorus levels in livestock/poultry manure
– Improved human nutrition through better mineral absorption by the
body
High omega-3 soybeans
– Much increased omega-3 levels for improved human health benefits
High stearic acid soybeans
– Up to six times more than conventional with improved food processing
benefits through reducing harmful fats
JPL – APPG on Science & Technology in Agriculture – 24/03/09
On the way…
…and not just an empty promise!
Long chain omega-3 fatty acids – a vital constituent in
our diets but rarely eaten at the recommended levels
Up to now, the only viable point of entry for the long
chain versions is through unsustainable fishing
Now successfully introduced into soybean
 Crops grown in field trials
 Human clinical trials completed
 Close to submission for regulatory approval
Will we ever see it on the UK shelves??
JPL – APPG on Science & Technology in Agriculture – 24/03/09
Maize
Corn
Amylase
(Syngenta)
High Lysine
(Monsanto)
SmartStax multiple
insect tolerance
(Dow / Monsanto)
2010
2011
DHP herbicide
resistance
(Dow)
NutriDense® corn increased
protein content, essential
amino acids & reduced
phytate content
(BASF)
2012
Herculex multiple
insect tolerance
(Dow / Pioneer)
Optimum GAT –
multiple herbicide
tolerance
(Pioneer)
JPL – APPG on Science & Technology in Agriculture – 24/03/09
>2012
Drought Tolerance
(Monsanto &
Syngenta)
Optimum AcreMax
multiple insect tolerance
stack (Pioneer)
Nitrogen-use efficiency
(Monsanto & Syngenta)
Maize
Corn
Amylase
(Syngenta)
High Lysine
(Monsanto)
SmartStax multiple
insect tolerance
(Dow / Monsanto)
2010
2011
DHP herbicide
resistance
(Dow)
NutriDense® corn increased
protein content, essential
amino acids & reduced
phytate content
(BASF)
2012
Herculex multiple
insect tolerance
(Dow / Pioneer)
Optimum GAT –
multiple herbicide
tolerance
(Pioneer)
JPL – APPG on Science & Technology in Agriculture – 24/03/09
>2012
Drought Tolerance
(Monsanto &
Syngenta)
Optimum AcreMax
multiple insect tolerance
stack (Pioneer)
Nitrogen-use efficiency
(Monsanto & Syngenta)
Maize – for farmers
Corn
Amylase
(Syngenta)
High Lysine
(Monsanto)
SmartStax multiple
insect tolerance
(Dow / Monsanto)
2010
2011
DHP herbicide
resistance
(Dow)
NutriDense® corn increased
protein content, essential
amino acids & reduced
phytate content
(BASF)
2012
Herculex multiple
insect tolerance
(Dow / Pioneer)
Optimum GAT –
multiple herbicide
tolerance
(Pioneer)
JPL – APPG on Science & Technology in Agriculture – 24/03/09
>2012
Drought Tolerance
(Monsanto &
Syngenta)
Optimum AcreMax
multiple insect tolerance
stack (Pioneer)
Nitrogen-use efficiency
(Monsanto & Syngenta)
Maize – for climate
change
Corn
Amylase
(Syngenta)
High Lysine
(Monsanto)
DHP herbicide
resistance
(Dow)
SmartStax multiple
insect tolerance
(Dow / Monsanto)
2010
2012
2011
Herculex multiple
insect tolerance
(Dow / Pioneer)
Optimum GAT –
multiple herbicide
tolerance
(Pioneer)
JPL – APPG on Science & Technology in Agriculture – 24/03/09
Optimum AcreMax
multiple insect tolerance
stack (Pioneer)
NutriDense® corn increased
protein content, essential
amino acids & reduced
phytate content
(BASF)
>2012
Drought Tolerance
(Monsanto &
Syngenta)
Nitrogen-use efficiency
(Monsanto & Syngenta)
Maize - Nutrition
Corn
Amylase
(Syngenta)
High Lysine
(Monsanto)
SmartStax multiple
insect tolerance
(Dow / Monsanto)
2010
2011
DHP herbicide
resistance
(Dow)
NutriDense® corn increased
protein content, essential
amino acids & reduced
phytate content
(BASF)
2012
Herculex multiple
insect tolerance
(Dow / Pioneer)
Optimum GAT –
multiple herbicide
tolerance
(Pioneer)
JPL – APPG on Science & Technology in Agriculture – 24/03/09
>2012
Drought Tolerance
(Monsanto &
Syngenta)
Optimum AcreMax
multiple insect tolerance
stack (Pioneer)
Nitrogen-use efficiency
(Monsanto & Syngenta)
More and more GM crops now have Multiple Gene
Additions
JPL – APPG on Science & Technology in Agriculture – 24/03/09
What does Bt (insect tolerance) do for your yield?
JPL – APPG on Science & Technology in Agriculture – 24/03/09
UK Specific Crops
Potatoes – esp BASF
– Blight Resistance – would have a
huge positive impact on potato
growing in UK and Ireland
– Industrial use – higher quality, lower
energy imput. Amflora currently
stuck in EU system
Oilseed Rape – esp Bayer & BASF
– Modified oils to include zero-trans and long chain fats
versions as well as Omega-3
– Even higher yielding versions on the way
JPL – APPG on Science & Technology in Agriculture – 24/03/09
China – already commercialised
PreProduction
Trial
Commercial
Activity
Crop
Field Trials
Environmental
Release
Cotton




Tobacco




Tomato




Sweet
Pepper




Papaya




Poplar Trees




Flowers




JPL – APPG on Science & Technology in Agriculture – 24/03/09
China – close to formal commercialisation
PreProduction
Trial
Commercial
Activity
Crop
Field Trials
Environmental
Release
Rice



2009?
Wheat



?
Maize



?
Soybean



?
Oilseed Rape



?
Chilli



?
Potato


Peanut


Cabbage


JPL – APPG on Science & Technology in Agriculture – 24/03/09
India
Crop
Trait
Research
Contained Field
Trials
Field Trials
Commercial
Activity
Cotton
Insect Resistance




Brinjal
(Eggplant)
Insect Resistance



2009
Cabbage
Insect Resistance


2009?
Cauliflower
Insect Resistance


2009?
Mustard
Increased Yield


Rice
Insect Resistance


Maize
Insect Resistance


Okra
Insect Resistance


Groundnut
Insect Resistance

Potato
Late Potato Blight

Tomato
Lycopene
enhancement

JPL – APPG on Science & Technology in Agriculture – 24/03/09
Public-Private Partnerships
Insect Resistant
Cabbage / Cauliflower
Super-Cassava
Golden Rice
Water-Efficient
Maize
JPL – APPG on Science & Technology in Agriculture – 24/03/09
So what about wheat?
Fusariumresistant wheat
RR Wheat
Insect Resistant
Wheat
Drought-tolerant
Wheat
DiseaseResistant Wheat
JPL – APPG on Science & Technology in Agriculture – 24/03/09
Conclusions
The first generation simple GM crops are being rapidly
supplanted by multiple gene stacked second generation
products
Different companies have different expertise in different
crops
Increasingly, crops containing quality traits are entering the
regulatory process
Public funding is starting to drive innovation in countries
such as India and China
Where normal business models are absent, public-private
partnerships allow access to this increasingly powerful
technology
JPL – APPG on Science & Technology in Agriculture – 24/03/09