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Supplementary Table 1. Summary of MRI abnormalities of our LBSL patients.
MRI abnormalities
van der
Knaap et al.
Patient
1
2
3
4
5
6
7
8
2003
Cerebral white
Periventricular white matter
+
+
+
+
+
+
+
+
+
Deep white matter
+
+
+
+
+
+
+
+
+
U-fibers
-
-
-
-
-
-
-
-
-
Posterior corpus callosum
+
+
-
+
+
+
+
+
+
Anterior corpus callosum
+/-
-
-
-
-
+
-
+
+
Posterior limb of internal capsule
+
+
+
+
+
+
+
+
+
Corona radiata
+
+
+
+
+
+
+
+
+
Cerebellar white matter
+/-
-
+
+
+
+
-
-
+
Cerebellar atrophy
+/-
-
-
-
-
-
-
HP
-
Pyramidal tracts
+
+
+
+
+
+
+
+
+
Medial lemniscus
+
-
-
-
-
+
-
-
-
Intraparenchymal trajectories of the
+
+
+
+
+
+
+
-
+
+
+
+
+
+
+
-
-
+
+/-
-
-
+
+
+
-
-
+
Superior cerebellar peduncles
+
+
+
+
+
+
+
-
+
Middle cerebellar peduncles
+/-
-
-
-
-
-
+
-
-
Inferior cerebellar peduncles
+
+
+
+
+
+
+
-
+
Anterior spinocerebellar tracts
+
-
-
-
+
+
-
-
-
Dorsal columns
+
NA1
+
+
NA
+
+
+
+
Lateral corticospinal tracts
+
NA1
NA
+
+
+
+
+
+
+/-
+
-
+
+
-
NA
-
-
17-
12-
8-18
3-12
10-
14
2-3
4-5
matter
Cerebellum
Brain stem
trigeminal nerve
Mesencephalic trigeminal tracts
Transverse pontine fibers
Spinal cord
Progression of
findings
Age at MRI (yrs)
MRI follow-up
30
20
13
8
11
10
9
1
1
(yrs)
Abbreviations: HP= hypoplasia, NA= not available, NA1,= Only sagittal images of the spinal cord available, showing abnormal
signal of the dorsal part
1
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