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The major sub-specialities are congenital, thoracic and adult cardiac, each with its own characteristics. Some surgeons have a mixed practice across thoracic and adult cardiac but most specialise in one of these areas. Thoracic surgery is, of course, dominated by the treatment of malignant disease, but this is not confined to bronchial carcinoma for important changes have occurred in the management of metastases and sarcomas. Problems of the pleural space such as pneumothorax, empyema and malignant pleural effusions are the daily fare of a thoracic surgeon. Mediastinal tumours and tracheal surgery are highly specialised areas. Oesophageal surgery is a challenging sub-speciality of thoracic surgery but a few talented surgeons have made this an absorbing career. Nowadays, thoracic surgeons collaborate with general surgeons and gastroenterologists in upper GI units. Arguably the most fascinating area of cardiac surgery is congenital practice because the challenges are significant both intellectually and technically but the rewards for successful repair of defects can be great. Many of these children, often neonates with complex defects, require further procedures later in life and so may come to be operated upon as adults. Hybrid procedures between interventional cardiologists and surgeons, for example, pulmonary valve replacement, are being developed in many centres. This is the most demanding type of cardiothoracic surgery and only a small group of highly talented surgeons perform these types of operations. In recent years the intensity of public and institutional scrutiny has increased markedly. Adult cardiac surgery is dominated by coronary heart disease but in an ageing population the requirement for valve surgery is rising fast. Coronary artery surgery is probably the most studied operation of all time. It is a big procedure but relatively safe with an early hospital mortality of 2%. This has been achieved despite the increasing age and comorbidity of patients undergoing the procedure. There continue to be innovations in valve surgery mainly in the area of tissue valves seeking to improve their durability. As the population of elderly patients increases, surgery of the thoracic aorta, including the aortic arch is expanding and provides opportunities to develop skills in endovascular stenting and to collaborate with vascular surgeons and interventional radiologists. The other major area is heart failure for which there are a range of surgical treatments from transplantation and ventricular assist devices to high risk coronary artery surgery, mitral valve repair and ventricular restraint devices. Surgeons in cardiothoracic surgery work closely with cardiologists or thoracic physicians. Attention to detail is essential as mistakes are not forgiven and may easily lead to the death of the patient during the operation. This feature distinguishes cardiac surgery in particular, from other branches of surgery. There have been three eras in cardiac surgery. In the first 20 years after 1950 surgeons were preoccupied in making cardiac surgery safe. Attention then turned to evaluating outcomes and analysing data to a very high level of sophistication. We are now in a third era concerned to reduce the morbidity of our operations by the use of minimal invasive techniques and to enable patients to benefit from the explosion of basic science research in vascular biology, tissue engineering, stem cells and many other areas. The surgeon at the bedside is in a very privileged position at the interface between the laboratory and the patient.