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E-mail : [email protected]
Personal Information
First name : Ariane
Surname : Sadr-Nabavi
 Date of Birth: 03.07.1975
Education
2002-2009
Germany
Ludwig Maximilian University of Munich (LMU), MVZ
German Board of Medical Genetics, German Society of Human Genetic
(GFH)( „Fachhumangenetiker/in (GfH)”)
2001-2006
Ludwig Maximilian University of Munich (LMU), Germany
(date of defence 23.06.2006 )
PhD of Human Genetic
The role of EFEMP1 gene and identification of candidate gens in sporadic Breast
Cancer
1995 – 2001
Ludwig Maximilian University of Munich (LMU), Germany
Master of Science in Human Genetic
Identification of candidategens in sporadic Breast and ovarial Cancer
Basic subject
Subsidiary subject
1993 – 1994
Experimental Science
Humangenetic
Genetic, Biochemistry, Immunology
Sara High School
Mashad, Iran
1990 – 1993
Kossar High School
Mathematics and Physics
Mashad, Iran
1998-1999
Institute of Molecular Genetic
Working with Yeast
Munich, Germany
2000-2001
Institute for oncology
Working on Ontological Cancer and Human genetic
Duesseldorf, Germany
2001-2005
Institute for Human Genetic
Working on Hereditary and Sporadic Breast Cancer
Human Genetic Consulting
Munich, Germany
Professional experience
2005-2009 MVZ Human Genetic
Working in the Humangenetic Laboratory
Human Genetic Consulting
Munich, Germany
2009-2012
sciences
Working in the medical genetic, mashhad University of medical
Patents and publications
Publications:
P1.Hami J, Sadr-Nabavi A, Sankian M, Balali-Mood M, Haghir H. The effects of maternal
diabetes on expression of insulin-like growth factor-1 and insulin receptors in male
developing rat hippocampus. Brain Struct Funct. 2012 Jan 13.
P2. Hosseini breshneh. A, Sadr-Nabavi A .(2012), Principle Ethics of
diagnostic tests in medical genetics, Genetics in the 3rd Millennium, 2012 Jan
21, (9) No: 4.
P3. Hami J, Sadr-Nabavi A. Sankian M, Haghir H. Sex differences and left-right
asymmetries in expression of insulin and insulin-like growth factor-1 receptors in developing
rat hippocampus. Brain Struct Funct. 2011 Nov 1.
P4. Sadr-Nabavi A, Ramser J, Volkmann J, Volkmann J, Naehrig J, Wiesmann F, Betz B, Hellebrand
Engert S, Seitz S, Kreutzfeld R, Sasaki T, Arnold N, Schmutzler R, Kiechle M, Niederacher D, Harbec
Dahl E, Meindl A. (2009). Decreased expression of angiogenesis antagonist EFEMP1 in sporadic bre
cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular
biomarker. Int J Cancer. 2009 Apr 1;124(7):1727-35
P5. Sadr-Nabavi A, Hoffmann M, Weilke C, Yu-Li Sun, and Nevinny-Stickel-Hinzpeter C. (2009) Mut
Scanning Using High Resolution Melting or dHPLC: A Performance Comparison StudyLightCycler® R
Time PCR Systems - Application Manual Jan 2008
P6.Dahl E, Sadr-Nabavi A, Klopocki E, Betz B, Grube S, Kreutzfeld R,
Himmelfarb M, An H, Gelling S, Klaman I et al. (2005).
Systematic identification and molecular characterization of genes
differentially expressed in breast and ovarian cancer." J Pathol”; 2005 (1): 21-8.
P7.G. Bastert, H.G. Bender, M.W. Beckmann, H. Caffier, C. Crohns,
J. Deininger, J. Dietl, N. Ditsch, W. Distler, L. Estevez-Schwarz, U.Hahn, H. Hepp
, N. Herröder, V. Hübbel, C. Hüttner, C. Jackisch,W. Jonat, M. Kandl, K. Kast, M.
Kaufmann , A. Kempe, M. Kiechle , Kreienberg, B. Kuschel, H.Luck, G. von Minckwitz, C.
Nestle-Krämling, B. Prieshof, K. Rensing, K. Rhiem, M. Schäffer, R.K. Schmutzler, U.
Schwarz-Boeger, L.Straub, M. Untch, T. Volm; Arbeitsgruppe ‘Humangenetik’: C.R.
Bartram, K. Bosse, I. Debatin, B. Fischer, U. Froster, D. Gadzicki, T. Goecke, T. Grimm,W.
Grote, L. Harder, D. Horn, J. Horst, F. Kreuz, U. Langenbeck, T. Neumann,I. Nippert,
P. Propping, D. Schäfer, B. Schlegelberger (Sprecherin), D.Schmidt, J. Schröder, R. Siebert
, K. Sperling, S. Strenge, W. Vogel, T. Voigtländer,B. Welling; Arbeitsgruppe
‘Molekulargenetik’: J. Arnemann, B. Betz, K.Bandick, I. Bendig, B. Dworniczak, E. Eberhardt
, W. Hofmann, K. Kast, R.Klaes, A. Kujat, A. Meindl, D. Niederacher, S. Preissler-Adams
, Sadr-Nabavi A, S. Scherneck, R.K. Schmutzler, B. Wappenschmidt, B.H.F. Weber;
Arbeitsgruppe ‘ Psychoonkologie’: I. Bodnar, R. Dahlbender, H. Faller, D.Fuchs,
K. Gebhardt, W.D. Gerber, A. Gonnermann, Ch. von derGroeben, P. Henningsen, S.
Hoppe, J. Jordan, A. Rohde, A. Sundermeier, A.Vodermaier, U. Wagner(2003).
Women’s Experiences of Undergoing BRCA1and BRCA2 Testing:
Organisation of the German Hereditary Breast and Ovarian
CancerConsortium”. Survey and Preliminary Datafrom.
“Community Genet”:249–258.
P8:Dahl E.,Sadr-Nabavi A., Klopocki E., Betz B., Grube S., Kreutzfeld R.,
Himmelfarb M.,Gelling S., Klaman I., Hinzmann B., Kristiansen G., Grützmann R,
Kuner R., Petschke B., Rhiem K., Wiechen K., Sers C., Wiestler O., Schneider A.,
Höfler H, Nährig J., Dietel :, Schäfer R., Rosenthal A, Schmutzler R., Dürst M.,
Niederacher D., Meindl A (2004)Hochdurchsatz-Identifizierung und
molekularbiologische Charakterisierung von Genen, die im Mammakarzinom
differentiell exprimiert werden.“Onkologie“ ;27(suppl 2):1–66
P9.Dahl,E.,Betz,B.,Dietel.M., Dürst.M.,., Gelling.S., Größl.S., Grützmann.R.
,Himmelfarb.M.,. Höfler.H., Klopocki.E., Kreutzfeld.R., Meindl. A, Niederacher.D, klaman.I.,
Rhiem.K., Sadr-Nabavi A, Schäfer R, Schmutzler A, Schneider A,
Wiesstler O, Kristiansen G., Rosenthal.A.
”Genetic Basis of Sporadic Gynaecological Carcinomas: molecular analysis and
validation of 50 candidate genes associated with sporadic breast, ovarian and
endometrial cancer”.
Progress Report 1999-2002
German Human Genome Projekt, Molecular Medicine.
Patents:
NCBI accession number: GenBank: JN686490.1
List of posters:
P1. Hami J, Sadr-Nabavi A. Sankian M, Haghir H .
"Sex differences and left-right asymmetries in expression of insulin and insulin-like
growth factor-1 receptors in developing rat hippocampus".
10th Iranian Anatomical sciences congress.(10-12May 2012)
P2. Sadr-Nabavi Ariane, Dastpak Mahtab,Homaei-Shandiz Fatemeh
,Bahrami Ahmad-Reza, Bidkhori Hamid-Reza, Raeesolmohaddeseen Mahmood
" Analyzing of new mutations in Iranian Families with Breast and
Ovarian cancer " .The 1st annual meeting of the middle-eastern
Association of cancer research (maerc 2011)
P3. Sadr-Nabavi A, Dastpak Mahtab,Homaei-Shandiz Fatemeh
,Bahrami Ahmad-Reza, Bidkhori Hamid-Reza, Raeesolmohaddeseen Mahmood
"Introduction of a new mutation in Iranian Families with Breast and
Ovarian cancer".4 the Tehran Brest Cancer Congress. (Okt2011).
P4. Sadr-Nabavi A, Sasannejad Pajam, Mojarad.M, Azarpajuh Reza,
Siadie Morteza2, Forugipur Mohsen2, Nikkhah karim, Me die Etemadie,
Mohamda Hasanzadeh Nazarabadie. Genetic analyses of the genes in
Hereditary Spastic Paraplegia. 12th Iranian Congress of Biochemistry
& 4th International Congress of Biochemistry & Molecular Biology
(September 2011)
P6. Sadr Nabavi A, Alizadeh M. Analyze of T-13910C polymorphism in the LCT
Gene in high consanguinity population Patients with hypolactasia.22 Jahrestagung
der Deutschen Geselschaft fur Humangenetik.(Marz 2011)
P7.Ghasemi . M.R Pirhoushiaran M ,.Zargari. P, Sadr-Nabavi .A.
Association Study for ACE , APOE , IL6 With Stroke.
3 the Cogress of Post. G. Student mashhad university of medical Since(Dec2011)
P8. Ghasemi .M.R., Sadr-Nabavi.A. Expression Analysis of On43 Gene
in Rat MCAO Model. the Cogress of Post. G. Student mashhad university
of medical Since(Dec2011).
P9. Sadr nabavi.A, Bahreini.M.T, Fardid.R Analyze of DNA repair genes
expression modification in peripheral blood lymphocytes the medical radiation
staff. 3the Congress of Laboratory and Clinic(Dec2011).
P10. Sadr- Nabavi.A, Hami.J, Haghir.H
The effects of maternal diabetes on expression of insulin-like
growth factor-1 and insulin receptors in male developing rat hippocampus.
3the Congress of Laboratory and Clinic(Dec2011).
P11. Tajeran.M. Baghbani.F, Per houshyaran.M, Shokohi.S, Sadr -Nabavi.A,
Hasanzadenazari.M .Subtelomeric analysis for screening idiopathic
mental retardation (IMR) children. 3the Congress of Laboratory
and Clinic(Dec2011).
P12. Betz,Beate., Czystowska, Malgorzata., Heimerzheim, Torsten.,Sadr-Nabavi, A.,
Meindl, Alfons.,Dahl, Edgar.,Neideracher, Dieter. (2003 May 25-28)
“Investigation of differentially expressed candidate gens in gynecological tumors“.
Genomics and Cancer, Integrating Genomics and Clinical Research, Heidelberg,
Germany.
P13. Dahl,E.,Betz,B.,Dietel.M., Dürst.M., Meindl., Gelling.S., Größl.S.,
Grützmann.R. Himmelfarb.M., Hinzmann.B., Höfler.H., Klopocki.E., Kreutzfeld.R., klaman.I
Rhiem.K., Kristiansen G., Kuner.R., Pilarsky.C., Rosenthal.A., Sadr-Nabavi.A.,
Schäfer.R., Schmitt.A., Schmutzler.R. Schneider. A., Specht.T, Wiestler.O
Niederacher.D, Meindl.A. (2003 May 25-28)
“Systematic identification and molecular characterization of gens
differentially expressed in gynecological cancer“.Genomics and Cancer,
Integrating Genomics and Clinical Research, Heidelberg, Germany.
P14. Sadr-Nabavi A., M.Du., B.Betz., D.Schmidt., E.Dahl., S.Gelling., B.Heinzmann.,
R.Kreutzfeld., R.,Schmutzler., A.Meindl.,D. Niederacher.(2002 May 25-29)
"Characterization of differntially expressed candidate gens associated with
gynaecological tumors ". European Human Genetics Conference 2002,
Strasbourg,
Eur. J. Hum. Genet. 10 (Suppl. 1): 109
Oral Presentations:
O1. Alizadeh. M, Sharifi.D, Jafarie.A,
Kianifar.H, Partowi.S,Hassanzade.N.M,
Sadr-Nabavi.A Evaluation of a genetic
test compare with lactose hydrogen
breath
test
for
hypolactasia.2
the
the
diagnosis
Iranian
of
medical
gentic congress.
(June2011)
O2. Sadr Nabavi A, Alizadeh M.
Analyze of T-13910C polymorphism in
the LCT Gene in population with high
Consanguinity. 12th Iranian Congress of
Biochemistry
&
4th
International
Congress of Biochemistry & Molecular
Biology(September 2011).
O3. Maryam Alizadeh Sedigh1,2
,Davood sharifi3 , Ali jaafari3,
Hamidrezakianifar3,
Simin
Hasanzadeh
Partovi3,
Nazar
Mohammad
abadi1.
Sadr-
Nabavi.A Evaluation of a genetic test
for diagnosis of primary hypolactasia in
Mashhad-Iran".. 2 end National and
International Congress on cellulare and
Molecular Advances in Non-Contagious
Diseases.(May2011). Diagnosis of
Hereditary Spastic Paraplegia
O4. Sadr -Nabavi.A, Etemadi.Mm,
Heidari.M, Mojarad.M, Froghi.M,
Saedi.M, Sasannejad.P, Hamzeloee.T,
Hasanzadenazari.M, Nickhah.K.
Diagnosis of Hereditary Spastic
Paraplegia.3the Congress of Laboratory
and Clinic(Dec2011).
O5. Alizadesedigh.M, Heidari.M,
Hasanzadenazari.M, Sharefi.D, Keani
far.H, Khalighi.A, Partoee.S, Hagher.H,
Gafari, Modaresi.Mh, Sadr- Nabavi.A
Analyze of CT-13910 Polymorphism in
the regulatory region of LCT Gene in
patients with hypolactasia. 3the
Congress of Laboratory and
Clinic(Dec2011).
O6. Mojarad.M, Sadr-Nabavi.A,
Akhondean.J, Ashrafzade.F,
Hasanzadenazari.M, Hamzeloee.T,
Froghi.M, Baghbani.F, Sarli.Ab,
Shokouhi.S, Hosseini.A, Raufean.R,
Perhoushyaran.M,, Tajeran.M
Association study between gene
polymorphism of CYP2C19, CYP2C9,
ABCB1 and abcc2 with drug therapy
resistance in epilepsy patients. 3the
Congress of Laboratory and
Clinic(Dec2011).
O7. Pirhoushyaran.M,
Hasanzadenazari.M,Azarpajoh.M,
Sasannejad.P, Etemadi.Mm,
Abaszadegan.M.R, Shokohi.S, Sarli.Ab,
Hosseini.A, Baghbani.F, Tajeran.M.
Sadr -Nabavi.A, Analyzing genes
related in Iranian children stroke. 3the
Congress of Laboratory and
Clinic(Dec2011).
Additional professional activities

Sequencing with ABI 377 and Capillary ABI 3100 and ABI 310

Polymerase Chain Reaction , PCR

DHPLC

Hybridization with Radioactivity and Fluorescent

Working with Bisulphite Reaction (BST)on DNS


Cloning for DNS
Western, soutern, northern blotting

Fragment analysis

RFLP

quantitative Chain Reaction , PCR

immunohistochemic

immunofluorescent

Light Cycler

Light Cycler 480

Magna Pure Roche

MLPA

Fragmentanalyse

FISH

Working with Genetic Database
Professional memberships

Member of ‘Human Genome Project’ , 2000-2012

Member of ‘Deutsche Krebshilfe‘ (German Cancer Aid), 2000-2004

Member of ‘Bayerischer Forschungsverbund Humangenetik-BFH’
(Bavarian Research Cooperation Human Genetics), since 2006

Member of ‘Deutsche Gesellschaft für Humangenetik- GfH’ (German
Society of Human Genetics), since 2004

Member of Reserch Socity of Mashad Unvivesity of Since, Since 2009

Member of Cancer Socity of Mashad Unvivesity of Since, Since 2010

Mamber of medical genetic Socity of Mashhad University of Since,
2012

Member of Neurogenetic Socity in Germany, 2012.
Executive employee

Head of research molecular laboratory in Institute for medical
genetic, Mashhad University of medical since.

Head of clinical genetic diagnostic laboratory in Gahem Hospital,
Mashhad University of medical since.

Head of clinical genetic diagnostic laboratory in Jahad medical
Center.
Research Projects
Primary Investigator:

Mutation analysis of the SPG4 gene in patients with Hereditary Spastic Paraplegia
(HSP).

Analysis of genetic factors(FV, FII, MTHFR, PAI, TNF, APOE, ACE, IL6, NOS,
paraoxonase,coagulation factor 13,platelet glycoprotein IIb,β2 adrenergic receptor and
angiotensin II receptor ) involving in Stroke.

Analysis
of
association
between
ABCB1,
CYP2C9,
CYP2C19,
ABCC2
gene
polymorphisms and resistance to drug therapy in epilepsy patient.

Mutation Scanning of all 24 Exons from BRCA1 Gen in women with familial and
hereditary breast and ovarian Cancer.

Evaluation of the association of maternal and off spring polymorphisms C677T and
A1298C of the MTHFR gene with the risk of non-syndromic cleft lip and /or palate.

Analyze of T-13910C Polymorphism Types in the LCT Gene in patients with
hypolactasemia problem.

Analysis of genetic factors involving in idiopathic Recurrent Spontaneous Abortion.
Co-Investigator:

Evaluation of delayed genotoxicity of sulphur mustard in Khorasan Razavi veterans
 Gene expression changes of P53, INF-G, TGF-B, XPA, G0S2, PF4 in lymphocytes of medical
radiation workers

The Assessment of Developmental Regulation of Insulin & Insulin Like Growth Factor- I
(IGF-I) Receptors in Hippocampal Formation in Neonate of Diabetic Rats.

Mobile Phone Radiation exposure effects on Bax and Bcl2 Genes Expression of
hippocampus in mice brain

Mobile Phone Radiation Exposure Effects on P53 and P21 Genes Expression in
Cerebellum of Balb/C Mice Brain
Students and Post Docs Advised
M.Sc. Awarded:
Alizadeh M (finish) 2011, Tohidie M (finish) 2011, , Mueller S
(finish). 2007, Castaneo P (finish). 2008
Gasemie MR (in Peogress) 2011, Bouromand Z (in Peogress)2011, Tajeran M(in
Peogress) 2010 , PirhushjaranM (in progress) 2010, Khanbabaie H (in Peogress) 2010,
Ph.D. Awarded:
Hami J. (finish) 2011, Fardid R (in progress) 2009, BehrawanE
M (in progress) 2010, DeholteM (in progress)2009