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Table S3 – Enriched KEGG pathways and GO Terms for biological process for the genes targeted by the regulated miRNA during
aging in Ames dwarf mice.
Pathways and GO Terms
KEGG pathways
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton
cGMP-PKG signaling pathway
Pathways in cancer
MAPK signaling pathway
Endocytosis
Proteoglycans in cancer
Axon guidance
Focal adhesion
Transcriptional misregulation in cancer
Dopaminergic synapse
Oocyte meiosis
Progesterone-mediated oocyte maturation
Thyroid hormone signaling pathway
AMPK signaling pathway
HTLV-I infection
cAMP signaling pathway
Rap1 signaling pathway
Wnt signaling pathway
Insulin signaling pathway
Adrenergic signaling in cardiomyocytes
Sphingolipid signaling pathway
GABAergic synapse
Glioma
Glutamatergic synapse
Prostate cancer
P value
Genes
miRNAs
0.020
0.001
2.41E-04
2.61E-04
0.001
2.82E-06
7.41E-07
1.18E-11
0.007
0.001
0.001
0.032
0.020
2.44E-09
2.61E-04
0.050
0.001
0.005
8.18E-08
0.003
0.026
0.003
0.003
0.001
2.41E-04
0.003
99
75
62
125
83
77
75
69
66
61
50
41
32
50
48
78
68
67
61
50
45
44
28
24
40
33
27
27
27
26
26
26
26
26
26
26
26
26
26
25
25
24
24
24
24
24
24
24
24
24
23
23
Morphine addiction
Signaling pathways regulating pluripotency of stem cells
Oxytocin signaling pathway
FoxO signaling pathway
Neurotrophin signaling pathway
T cell receptor signaling pathway
ErbB signaling pathway
mTOR signaling pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Hippo signaling pathway
Protein processing in endoplasmic reticulum
TGF-beta signaling pathway
Estrogen signaling pathway
Choline metabolism in cancer
Long-term depression
Dorso-ventral axis formation
Phosphatidylinositol signaling system
Long-term potentiation
Thyroid hormone synthesis
Circadian rhythm
Hepatitis B
Adherens junction
Amphetamine addiction
Gap junction
Inositol phosphate metabolism
Renal cell carcinoma
Chronic myeloid leukemia
Hedgehog signaling pathway
Lysine degradation
Melanogenesis
Osteoclast differentiation
0.004
1.12E-07
0.004
2.80E-05
2.61E-04
4.75E-04
0.003
0.001
0.003
4.63E-10
2.87E-04
6.09E-05
2.61E-04
0.017
0.048
0.007
0.004
0.001
0.003
0.004
0.035
0.003
2.82E-06
0.026
0.009
0.003
0.036
0.002
0.025
2.87E-04
0.020
29
59
56
55
49
41
31
28
25
60
59
37
37
35
19
13
33
30
20
16
41
32
29
25
23
27
26
23
15
40
40
23
22
22
22
22
22
22
22
22
21
21
21
21
21
21
21
20
20
20
20
19
19
19
19
19
18
18
18
18
17
17
Sphingolipid metabolism
Basal cell carcinoma
Notch signaling pathway
Nicotine addiction
Cocaine addiction
Thyroid cancer
Fatty acid metabolism
Glycosphingolipid biosynthesis - lacto and neolacto series
Prion diseases
Glycosphingolipid biosynthesis - ganglio series
0.007
0.001
0.032
0.030
4.19E-04
0.032
0.050
0.006
3.64E-13
0.001
16
26
19
14
18
10
9
6
11
6
16
15
15
15
14
14
14
12
11
6
GO Term Biological Processes
Cellular nitrogen compound metabolic process
Anatomical structure development
Cell differentiation
Cellular protein modification process
Cellular component assembly
Biosynthetic process
Embryo development
Cell cycle
Anatomical structure formation involved in morphogenesis
Cell morphogenesis
Homeostatic process
Cell death
Cytoskeleton organization
Cell motility
Chromosome organization
Growth
Cell-cell signaling
Cell division
In utero embryonic development
8.07E-21
6.08E-207
9.66E-116
2.56E-32
0.003
2.43E-18
9.36E-72
1.78E-12
3.26E-49
2.63E-48
4.44E-10
0.001
4.05E-10
1.01E-18
7.18E-31
5.73E-13
1.11E-04
2.09E-13
0.001
1144
1216
913
682
303
1004
359
311
304
278
248
228
215
210
206
148
174
169
112
32
31
31
31
31
30
30
30
30
30
30
30
30
30
30
30
29
29
29
Developmental maturation
Circulatory system process
Odontogenesis of dentin-containing tooth
1.61E-12
0.001
0.032
63
50
34
27
23
22