Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Common cold wikipedia , lookup
Vaccination wikipedia , lookup
Transmission (medicine) wikipedia , lookup
DNA vaccination wikipedia , lookup
Neonatal infection wikipedia , lookup
Infection control wikipedia , lookup
Marburg virus disease wikipedia , lookup
Human cytomegalovirus wikipedia , lookup
Childhood immunizations in the United States wikipedia , lookup
Viral Hepatitis Australian Family Physician Vol. 30 No.5, May 2001 Presented by 郭詠怡 Date presented:25/8/2003 Causes of hepatitis HAV: Enteric HBV: Blood borne HCV: Blood borne HDV: Blood borne HEV: Enteric HGV: Blood borne incubation (days): 15-60 45-160 14-120 42-180 15-64 unknown HAV and HEV: with water/ food outbreaks ( travelling to developing world). No chronic carriers HBV and HCV: STD, injecting drug use, occupational exposure in health care worker, causing acute and chronic hepatitis, carriers,, hepatocellular carcinoma HDV: super infection or coinfection with HBV HGV: possibly causes transfusion hepatitis Other causes of hepatitis Other viruses: Herpes viruses -CMV -EBV Yellow fever virus Other causes: nonviral infections, drugs, alcohol, anoxic liver injury Needlestick exposure Collection nurse (recipient) Skin unbroken? Gloves worn? Had blood been drawn or was sterile needle involved? Did injury result in blood being drawn? Patient (source) Injection drug use Sexual preference Blood ransfusions Overseas travel Migration history Tests to order after needlestick exposure On the patient (source) HIV Ab, HBsAg, HCV Ab On the nurse (recipient) HBsAb, storage of serum Main clinical presentations in viral hepatitis HAV: --acute hepatitis in adults—(75% symptomatic, but self limiting); children usually asymptomatic --fulminant hepatitis (rare) HBV: --acute hepatitis (mostly self limiting,50% asymptomatic) --fulminant hepatitis (specially if coinfected with HDVor concurrent HCV --chronic hepatitis leading to carrier state 5-10% Main clinical presentations in viral hepatitis HCV: --chronic hepatitis leading to carrier state 50-70% --acute hepatitis (75% asymptomatic) --fulminant hepatitis (uncommon, seen with concurrent HBV HDV: --acute exacerbation in chronic hepatitis B (HDV superinfection) --fulminant hepatitis ( if coinfected with HBV) --chronic hepatitis leading to carrier state (variable 5-70%) HEV: --acutehepatitis (usually self limiting) -- fulminant hepatitis (rare, but seen in pregnant women) Hepatitis serology HAV HBV HCV clinical situation acute hepatitis see next slide acute hepatitis chronic carrier HDV(only coinfection or if HbsAg+) superinfection HEV acute hepatitis HGV tests to order HAV IgM HCV Ab, HCV PCR HCV Ab HBsAG, HBcIgM, HDV Ab HEV Ab HGV PCR HBV serology Late incubation period: HBsAg Acute hepatitis: HBsAg, HBcIgM, HBcAb Total, HBeAb, HBV DNA Window period: HBcIgM, HBcAb Total, HBV DNA Healthy carrier: HBsAg, HBcAb Total, HBeAb Chronic carrier/ replicative: HBsAg, HBcAb total, HBeAg, HBV DNA Recovery/immunity: HBcAb Total Recent vaccination: HBsAb Treatment for viral hepatitis Virus A,E,G B,D C Antiviral not available interferon+lamivudine interferon+ribavirin Prevention of viral hepatitis Virus A B,D Vaccine Schedule Havrix or 2 doses at 0 VAQTA and 6 months Engerix B 3 doses at 0,1,6 or HBVax II months Summary of important points Most cases of viral hepatitis are self limiting or asymptomatic Epidermiological hisory is helpful to determine which tests to order There are a number of markers for HBV, used for different stages of the disease. Vaccination can prevent infection with certain hepatitis viruses, eg. HAV and HBV The role of some new viruses thought to cause hepatitis is controversial