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Download Appendix 7 Drug Interactions – Protease Inhibitors Side Effects
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Appendix 7 Drug Interactions – Protease Inhibitors Side Effects GI tract Nervous system Skin Kidney Liver Blood disorder Metabolism GI tract Nervous system Skin Kidney Liver Blood disorder Metabolism GI tract Skin Nervous system Metabolism Pancreas Liver Indinavir Diarrhoea, nausea and vomiting abdominal discomfort, dry mouth, taste disturbances Headache, dizziness, insomnia, myalgia, asthenia Kaletra Diarrhoea, nausea, vomiting and stomach pain. Headache, fatigue. Rash (including Stevens-Johnson syndrome, pruritus, dry skin, hyperpigmentation Nephrolithiasis – kidney stone, dysuria, haematuria, crystaluria, proteinuria Elevated liver enzymes and bilirubin, hepatitis Neutropenia, haemolytic anaemia Lipodystrophy and Diabetes Rash Saquinavir Diarrhoea, stomach pain, nausea. Abnormal liver enzymes. Lipodystrophy Fos Amprenavir Nausea, vomiting and diarrhoea. Headache, fatigue, tingling around the mouth. Rash. Atazanavir Diarrhoea. Abnormal liver function and jaundice Lipodystrophy and metabolic abnormalities. Lipodystrophy and metobolic abnormalities. Efavirenz (NNRTI) Diarrhoea, nausea Rash (including Stevens-Johnson syndrome Headache, dizziness, insomnia, somnolence, abnormal dreams, fatigue, impaired concentration, depression, psychosis Raised plasma triglycerides and cholesterol Pancreatitis, Elevated liver enzymes GI tract Nervous system Skin Kidney Pancreas Blood disorder Liver Metabolism Zidovudine (AZT,ZDV) Nausea and vomiting, abdominal pain, dyspepsia, diarrhoea Headache, fever, myalgia, paraethesia, neuropathy, dizziness, somnolence, insomnia, malaise and asthenia Pigmentation of nail, skin and oral mucosa Pancreatitis Anaemia, neutropenia, leucopoenia Fatty change and raised bilirubin and liver enzyme Lactic acidosis Common side effects are in bold Didanosine (ddI) Diarrhoea, nausea and vomiting, dry mouth, taste Stavudine (d4T) Lamivudine (3TC) Diarrhoea, nausea and vomiting Peripheral neuropathy Peripheral neuropathy (19-24%) Headache, Insomnia, malaise, peripheral neuropathy Rash hyperuricaemia Pancreatitis Pancreatitis Neutropenia, anaemia Elevated liver function test Elevated liver function test (11-13%) Lactic acidosis Elevated liver enzymes
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