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Skeletal muscle MRI of the thigh in patient with Bethlem myopathy reveals moderate involvement of thigh muscles with the "central shadow" within the rectus femoris, atrophy and increased abnormal signal at the periphery of the vastus lateralis, and fatty replacement between the vastus lateralis and the vastus intermedius. Source: Muscular Dystrophies, Neuromuscular Disorders, 2e Citation: Amato AA, Russell JA. Neuromuscular Disorders, 2e; 2015 Available at: http://mhmedical.com/ Accessed: May 04, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved