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Yoon-Young Jang, Ph.D. / M.D.
(Last updated : 2013-02-01)
Institute for Cell Engineering. Johns Hopkins University School of
Medicine, Baltimore, MD, USA
Education
1998. M.D. College of Medicine, Chung-Ang University, Seoul, Korea
2002. Ph.D. College of Medicine Chung-Ang University, Seoul, Korea
Professional Experiences
2002 - 2004 Postdoctoral Fellow, The Johns Hopkins University, Baltimore, MD
2005 - 2008 Instructor, The Johns Hopkins University, Baltimore, MD
2008 - Assistant Professor, Stem Cell Biology Laboratory, Sidney Kimmel Comprehensive Cancer Center,
The Johns Hopkins University, Baltimore, MD
Key publications (selected from over 45)
1. Jang YY, Collector MI, Baylin SB, Diehl AM, Sharkis SJ. (2004) Hematopoietic stem cells convert into
liver cells within days without fusion. Nature Cell Biol. 6: 532-9.
2. Jang YY (Corresponding author), Sharkis SJ. (2007) A low level of reactive oxygen species selects for
primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood. 110: 3056-3063
(Commented in Blood, 2007: 110: 2783-2784).
3. Jang YY (Corresponding author), Sharkis SJ. (2007)
Fetal to adult stem cell transition: knocking Sox17
off. Cell. 130:403-404.
4. Ye Z, Zhan H, Mali P, Dowey S, Jang YY, Dang CV, Spivak JL, Moliterno AR, Cheng L (2009). Human
induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood
disorders. Blood. 114: 5473-5480. (Commented in Blood. 2009 114:5409-10)
5. Liu H, Ye Z, Kim Y, Sharkis S, Jang YY (Corresponding author) (2010) Generation of endodermderived human induced pluripotent stem cells from primary hepatocytes. Hepatology 51(5):1810-1819.
6. Jang YY (Corresponding author), Ye Z and Cheng L. (2011) Molecular Imaging and Stem Cell Research.
Molecular Imaging ;10(2):111-122.
7. Liu H, Kim Y, Sharkis S, Marchionni L and Jang YY (Corresponding author) (2011). In vivo Liver
Regeneration Potential of Human Induced Pluripotent Stem Cells from Diverse Origins. Science Transl.
Med. 3(82): 82ra39. (Cover image in Science Transl Med, highlighted in Cell, leading edge select 2011,
146: 5.)
8. Choi SM, Liu H, Chaudhari P, Kim Y, Cheng L, Feng J, Sharkis, S, Ye Z and Jang YY (Corresponding
author) (2011). Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent
stem cells. Blood, 2011, 118(7): 1801-1805.
9. Fan J, Robert C, Jang YY, Liu H, Sharkis S, Baylin SB, Rassool FV. Human induced pluripotent cells
resemble embryonic stem cells demonstrating enhanced levels of DNA repair and efficacy of
nonhomologous end-joining. Mutat Res. 2011;713(1-2):8-17.
10. Choi SM, Kim Y, Liu H, Chaudhari P, Ye Z, Jang YY (Corresponding author) (2011) Liver engraftment
potential of hepatic cells derived from patient-specific induced pluripotent stem cells. Cell Cycle.
2011;10(15):2423-7 (Cover image)
11. Ye Z, Liu CF and Jang YY (Corresponding author) (2011). Hematopoietic cells as sources for patientspecific iPSCs and disease modeling. Cell Cycle 2011; 10(17).
12.
Sharkis S, Jones R, Civin, C, Jang YY (Corresponding author). Pluripotent stem cell-based cancer
therapy: Promise and challenges. Science Transl. Med. 4, 127ps9 (2012).
13. Tsai HC, Li H, Van Neste L, Cai Y, Robert C, Rassool FV, Shin JJ, Harbom KM, Beaty R, Pappou E,
Harris J, Yen RW, Ahuja N, Brock MV, Stearns V, Feller-Kopman D, Yarmus LB, Lin YC, Welm AL, Issa JP,
Minn I, Matsui W, Jang YY, Sharkis SJ, Baylin SB, Zahnow CA. Transient Low Doses of DNADemethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor Cells.
Cancer Cell. 2012; 21(3):430-446. PMCID: PMC3312044 (highlighted in Cell Stem Cell 2012 10: 353-354).
14. Chaudhari P, Ye Z, and Jang YY (Corresponding author). Roles of reactive oxygen species in the fate
of stem cells. Antioxid Redox Signal. 2012 Oct 15. [Epub ahead of print]
15. Choi SM, Kim Y, Shim JS, Park JT, Wang RH, Leach SD, Liu JO, Deng CX, Ye Z, Jang YY
(Corresponding author). Efficient drug screening and gene correction for treating liver disease using
patient-specific stem cells. Hepatology. 2013 Jan 16. doi: 10.1002/hep.26237. [Epub ahead of print]
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