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CURRICULUM VITAE
I. GENERAL INFORMATION
Name:
David P. Bichell, M.D.
Office Address:
Professor, Cardiac Surgery
Chief, Pediatric Cardiac Surgery
Vanderbilt University
Monroe Carell Children‟s Hospital
5247 Doctor‟s Office Tower
2200 Children‟s Way
Nashville, TN 37232-9292
Phone: 615.936.5500
Fax: 615.343.0042
Home Address:
1510 Old Hickory Blvd.
Brentwood, TN 37027
Place of birth:
Baltimore, Maryland
E-mail:
[email protected]
Education:
1987
1980
M.D., Columbia University College of Physicians &
Surgeons
B.A., Johns Hopkins University
Post-doctoral training:
1997
Chief Resident in Cardiac Surgery, Children‟s
Hospital, Harvard Medical School
1996-97
Chief Resident in Cardiac Surgery, Brigham & Women‟s
Hospital, Harvard Medical School
1995-96
Resident in Cardiothoracic Surgery, Brigham &
Women‟s Hospital, Harvard Medical School
1994-95
Clinical Fellow in Cardiac Surgery, Brigham &
Women‟s Hospital, Harvard Medical School
1988-94
Resident in General Surgery, Barnes Hospital,
Washington University School of Medicine
1990-92
Research Fellow, Departments of Biochemistry and
Surgery, Washington University School of Medicine
1987-88
Intern in Pediatrics, Columbia-Presbyterian
Hospital, Columbia University
Licensure and Certification:
Medical license, State of Tennesee #40434, issued October 31, 2005
Medical license, State of Illinois #036-113863, issued June 14, 2005
Medical license, State of Hawaii #11457, issued April 2, 2001
Medical license, State of California #G084908, issued October 30, 1998
Diplomate, American Board of Thoracic Surgery #6048, June 5, 1998
Diplomate, American Board of Surgery #4095, February 27, 1996
Medical license, State of Massachusetts #78974, issued February 23,
1994
Professional Memberships:
Chicago Surgical Society
Midwest Pediatric Cardiology Society
Fellow, American College of Surgeons
Society of Thoracic Surgeons
Congenital Heart Surgeon‟s Society
Western Thoracic Surgical Association
Western Society of Pediatric Cardiology
Hospital or Affiliated Institution Appointments:
2006-
Professor of Cardiac Surgery
Chief, Pediatric Cardiac Surgery
Vanderbilt University
Monroe Carell Jr. Children‟s Hospital
2005-2006
Associate Professor of Surgery
Department of Surgery, Section of Cardiothoracic Surgery
University of Chicago
2005-2006
Director of Pediatric Cardiac Surgery
University of Chicago Hospitals, Comer Children's Hospital
2000-2005
Director, Division of Cardiovascular Surgery,
Children‟s Hospital, San Diego
2000-2005
Director, The Children‟s Heart Institute,
Children‟s Hospital, San Diego
2000-2004
Section Chief, Thoracic Surgery, Children‟s Hospital, San
Diego
1999-2000
Associate in Cardiovascular Surgery,
Children‟s Hospital, San Diego
1997-98
Instructor, Department of Cardiovascular Surgery,
Children‟s Hospital Boston, Harvard Medical School
Administrative Responsibilities:
2003-2005 Board of Directors, Children‟s Specialists of San Diego
2000-2005
Medical Director, Children‟s Heart Institute, San Diego
2003-2005
At-Large Surgeon, Children‟s Specialists of San Diego
Hospital Committee Assignments:
2003-2005 Academic Affairs Committee, Children‟s Specialists of San
Diego
Other Positions:
1980-92
Freelance illustrator, W.B Saunders Publishers,
Little, Brown & Company Publishers, Columbia
University, Johns Hopkins University, Harvard
University Press, William Morrow Publishers
Ad Hoc Reviewer:
2006Journal of Surgical Research
2004-
Journal of Thoracic and Cardiovascular Surgery
2001-
Annals of Thoracic Surgery
2000-
New England Journal of Medicine
Awards and Honors:
1994
Eugene Bricker Award, Washington University
1992
American Federation of Clinical Investigators
Excellence in Research Award
1987
Joseph Garrison Parker Award, Columbia University
1985-87
Joseph Collins Scholarship, Columbia University
II. RESEARCH, TEACHING, AND CLINICAL CONTRIBUTIONS
A. Current Clinical Activities:
Director of Pediatric Cardiac Surgery at Monroe Carell Jr. Children‟s
Hospital, Vanderbilt University, a department performing over 500
operations per year in a practice treating exclusively congenital heart
disease.
B. Clinical Investigations:
Current:
Principal investigators: David Bichell, M.D., Julia Noland, PhD.
“Hearts & Minds” study:Neurodevelopmental testing in the pre-, peri-, and
late postoperative period in infants undergoing single ventricle surgical
palliation, including evoked response potential (ERP) and serum markers
of hypoxic/ischemic stress, and novel early neurodevelopmental testing of
executive function.
Sponsor: Children‟s Fund, Monroe Carell Jr. Childrens Hospital at
Vanderbilt, $100,000
Principal Investigator: David Bichell, M.D.
The Contegra bovine jugular vein valved conduit multicenter clinical study
#9202-99C (enrollment closed, follow up ongoing)
Sponsor: Medtronic, Inc., Minneapolis, MN
Principal investigator: David Bichell, M.D.
Congenital Heart Surgeons‟ Society (CHSS) multicenter studies of
congenital heart disease
Sponsor: CHSS, The Hospital for Sick Children, Toronto
Past:
Principal Investigator: David Bichell, M.D.
Platelet aggregation inhibition in children on Clopidogrel (PICOLO), study
No. PDY4422
Dose-ranging pharmacodynamic assessment of platelet aggregation
inhibition with clopidogrel in children of Blalock-Taussig shunt age
categories neonates and infants/toddlers
Sponsor: Sanofi-Synthelabo, Malvern, PA
Principal investigator: David Bichell, M.D.
Co-investigators: Michael Worthen, M.D.,Kathleen Kaya, M.D., Michael
Flynn, M.D.
ETHIC clinical study, protocol # 20,015-004. A multicenter study to
evaluate the efficacy, safety, and pharmacokinetics of Brevibloc (Esmolol
Hydrochloride) for the treatment of hypertension in infants and children
after surgical repair of coarctation of the aorta.
Sponsor: Baxter Pharmaceutical Products, Inc., New Providence, NJ
Principal investigator: David Bichell, M.D.
Retrospective study of the surgical treatment for ostium secundum atrial
septal defect – A surgical arm of the multicenter pivotal study of the
HELEX septal occluder, (principal investigator: Frank Ing, M.D.)
Sponsor: W.L. Gore & Associates, Inc., Flagstaff, AZ
C. Teaching:
a. Seminars, lectures, invited presentations
Invited speaker, Nashville Surgical Society. Current Management of
Hypoplastic Left Heart Syndrome. March 6, 2008, Nashville, TN.
Invited speaker, STS/Tech-Com Program: Evaluation of Adults with
Congenital Heart Disease. January 27, 2008, Ft. Lauderdale, FL
Invited speaker, XLIII Congreso Chileano de Cardiologia y Cirugia
Cardiovascular: Advances in Cardiopulmonary Bypass: Optimizing the
neurologic outcome after congenital heart surgery. November 29, 2006,
Vina del Mar, Chile
Invited speaker, XLIII Congreso Chileano de Cardiologia y Cirugia
Cardiovascular:Primary Repair of tetralogy of Fallot in Infancy. November
30, 2006, Vina del Mar, Chile
Invited speaker, XLIII Congreso Chileano de Cardiologia y Cirugia
Cardiovascular: Rehabilitation of Pulmonary Arteries in Congenital Heart
disease. November 30, 2006, Vina del Mar, Chile
Invited speaker, American College of Surgeons 2006: Postgraduate
review course: Adult congenital cardiac disease. October 12, 2006,
Chicago, IL
Invited speaker, PICS 2006: Intraoperative stents. September 13, 2006,
Las Vegas, NV.
Invited speaker, PICS 2006: Dealing with stents in the operating room.
September 12, 2006, Las Vegas, NV
Visiting professor invited presentation, Mary Bridge Children‟s Hospital:
Challenges in the treatment of complex pulmonary artery problems.
August 11, 2006, Tacoma WA
Invited Speaker, SCAI 29th Annual Scientific Sessions: Critical aortic valve
stenosis in the neonate: Surgery should be the first option. May 11, 2006,
Chicago, IL
Invited speaker, PICS IX/ENTICHS 2005: Long term outcome following
the surgical closure of atrial septal defect. September 16, 2005, Buenos
Aires, Argentina
Invited speaker, Mexican Society of Cardiac Surgery XIV International
Congrss: Right ventricle to pulmonary artery conduits. March 31, 2005,
Monterrey, Mexico
Invited speaker, Mexican Society of Cardiac Surgery XIV International
Congress: Management strategies for pulmonary hypertension. March 31,
2005, Monterrey, Mexico
Visiting professor presentation, Vanderbilt University: Right ventricle to
pulmonary artery conduits: Alternatives to the homograft. March 4, 2005,
Nashville, Tennessee
Invited speaker, The Fetus & Newborn: State of the Art Care Conference:
Practical neonatal cardiology: What you really need to know. October 20,
2004, La Jolla, California
Invited speaker, 2004 Neonatal-perinatal symposium: Advances in
Neonatal Cardiothoracic Surgery. September 10, 2004, Long Beach
California
Program Director, Congenital Cardiovascular Surgery Symposium,
October 15-16, 2004, San Diego, California
Speaker, Congenital Cardiovascular Surgery Symposium: Homografts in
Infants and Children. October 15, 2004, San Diego, California
Invited speaker, III Congresso Internationale de Terapia Intensiva
Pediatrica: Management of Hypoplastic Left Heart Syndrome and Cardiac
Transplantation. June 21-25, 2004, Monterrey, Mexico
Invited Speaker, ENT Division lecture series, Children‟s Hospital San
Diego. Vascular Rings. June 13, 2003
Invited Speaker, Balboa Naval Hospital, Department of Pediatrics. Single
Ventricle Physiology. April 22, 2003, San Diego, California
Invited speaker, Grand Rounds, Children‟s Hospital San Diego: Advances
in Congenital Cardiovascular Surgery. February 15, 2002, San Diego,
California
Invited speaker, Grand Rounds, Mercy Hospital: Advances in Congenital
Cardiovascular Surgery. May, 2000, San Diego, California
Invited speaker, California Society of Pediatric Cardiology Annual Meeting:
Pacemakers. September, 1999, Del Mar, California
Invited speaker, Frontiers in Diagnosis and Management of Congenital
Heart Disease: Multiple Ventricular Septal Defects: Which VSD should be
Left for the Surgeon? April 30- May 2, 1998, Boston, Massachussetts
b. Local contributions, advisory and supervisory responsibilities
2000-2005: Sponsor and supervisor, clinical fellow in Congenital
Cardiovascular Surgery
Rajeev Gulati, M.D. (2003-4)
Douglas C. Wallace, M.D. (2004-5)
III. BIBLIOGRAPHY
Original Articles:
Antevil JL, Doyle TP, Bichell DP, Christian KG: Congenitally Corrected
Transposition of the Great Arteries: A Unique Case from Iraq. Pediatr
Cardiol 2010:31(1): 120.
Soslow JH, Parra DA, Bichell DP, Dodd DA. Left ventricular hernia in a pediatric
transplant recipient: Case report and review of literature. Pediatr Cardiol
2009:30:55-58.
Scott JW, Karamichalis JM, Ing FI, Shirai L, Bichell D. Staged left pulmonary
artery rehabilitation in post-Fontan left pulmonary artery hypoplasia. Ann
Thorac Surg 2007;84:2112-4.
Bichell DP, Mora BN, Mathewson JW, Kirkpatrick SK, Tyner JJ, McLeesPalinkas T. Modified technique for the surgical treatment of severe
tricuspid valve deformity in Ebstein‟s anomaly. Ann Thorac Surg
2007;83:678–80
Kurio G, Bichell DP, Perry JC. Malalignment of the septum primum with
abnormally positioned left atrial appendage: Unusual combination in a
Shone‟s heart. Pediatr Cardiol. 2006;27:628-32.
Bichell, DP, Lamberti JJ, Pelletier GJ, Hoecker C, Cocalis MW, Ing FF,
Jensen RA. Late left pulmonary artery stenosis after the Norwood
procedure is prevented by a modification in shunt construction. Ann
Thorac Surg 2005;79:1656-60.
Mathewson JW, Bichell DP, Rothman A, Ing FF. Absent posteroinferior and
anterosuperior atrial septal defect rims: Factors affecting nonsurgical
closure of large secundum defects using the Amplatzer occluder. J Am
Soc Echocardiogr. 2004 Jan; 17(1): 62-9.
Nicholson IA, Bichell DP, Bacha EA, del Nido PJ. Minimal sternotomy approach
for congenital heart operations. Ann Thorac Surg 2001;71:469-72.
Bichell DP, Geva T, Mayer JE, Jonas RA and del Nido PJ. Minimal access
approach for the repair of atrial septal defect: the initial 135 patients.
Ann Thorac Surg 2000;70:115-8.
Bichell DP, Saenz NC, Losasso BE and Sobo EJ. Pediatric aortic
pseudoaneurysm associated with a gunshot wound to the chest. J
Trauma 2000;48:791.
Laussen PC, Bichell DP, McGowan FX, Zurakowski D, DeMaso D, and del Nido
PJ. Postoperative recovery in children after minimum versus full-length
sternotomy. Ann Thorac Surg 2000;69:591-6.
Jahangiri M, Zurakowski D, Bichell D, Mayer JE, del Nido PJ and Jonas RA.
Improved results with selective management in pulmonary atresia with
intact ventricular septum. J Thorac Cardiovasc Surg 1999;118:1046-55.
Visconti KJ, Bichell DP, Jonas RA, Newberger JW, and Bellinger DC.
Developmental outcome after surgical versus interventional closure
of secundum atrial septal defect in children. Circulation
1999;100[suppl II]:II-145-50.
del Nido P, Bichell D. „Minimal-access‟ congenital heart surgery.
Thorac Cardiovasc Surg, 1998, 1:75-80.
Seminars
Cohn LH, Adams DH, Couper GS, Bichell DP, Rosborough DM, Sears S, and
Aranki SA. Minimally invasive cardiac valve surgery improves patient
satisfaction while reducing costs of cardiac valve replacement
and repair. Ann Surg 1997, 226:421-8.
Cohn LH, Adams DH, Couper GS, and Bichell DP. Minimally invasive aortic
valve replacement. Seminars Thorac Cardiovasc Surg 1997, 9:331-6.
Bichell DP, Balaguer J, Aranki SA, Adams DH, Couper GS, Rizzo R, and Cohn
LH. Axillo-axillary bypass: A practical alternative to femoro-femoral
bypass. Ann Thorac Surg 1997, 64:702-5.
Gates J, Bichell D, Rizzo R, Couper G, and Donaldson M. Thigh ischemia
complicating femoral vessel cannulation for cardiopulmonary bypass. Ann
Thorac Surg 1996, 61:730-3.
Bichell D, Adams D, Aranki S, Rizzo R, and Cohn L. Repair of mitral
regurgitation from myxomatous degeneration in the patient with a
severely calcified posterior annulus. J Cardiac Surg 1995, 10:281-4.
Thomas M, Kikuchi K, Bichell D and Rotwein P. Characterization of
deoxyribonucleic acid-protein interactions at a Growth Hormone-inducible
Nuclease hypersensitivity site in the rat Insulin-like Growth Factor-I gene.
Endocrinol 1995, 136:562-9.
Thomas M, Kikuchi K, Bichell D and Rotwein P. Rapid activation of rat Insulinlike Growth Factor-I gene transcription by Growth Hormone reveals no
alterations in deoxyribonucleic acid-protein interaction within the major
promoter. Endocrinol 1995, 135:1584-92.
Bichell D, Rotwein P and McCarthy T. Prostaglandin E2 rapidly stimulates
Insulin-like Growth Factor-I gene expression in primary rat osteoblast
cultures: Evidence for transcriptional control. Endocrinol 1993, 133:10208.
Rotwein P, Bichell D and Kikuchi K. Multifactorial regulation of IGF-I gene
expression. Mol Repro Devel 1993, 35:358-64.
Kikuchi K, Bichell D and Rotwein P. Chromatin changes accompany the
developmental activation of Insulin-like Growth Factor-I gene
transcription. J Biol Chem 1992, 267:21505-11.
Hall L, Kajimoto Y,Bichell D, Kim S, Payton J, Counts D, Nixon L, Tobin G and
Rotwein P. Functional analysis of the rat Insulin-like Growth Factor-I
gene promoter. DNA Cell Biol 1992, 11:301-13.
Bichell D, Kikuchi K and Rotwein P. Growth Hormone rapidly activates
Insulin-like Growth Factor-I gene transcription in vivo. Mol Endocrinol
1992, 6:1899-1908.
Pollard T, Tseng P, Rimm D, Bichell D, Williams R, Sinard J and Sato M.
Characterization of alpha-actin from Acanthamoeba. Cell Motility
Cytoskeleton 1986, 6:649-61.
Abstracts:
Lichtenstein BJ, Seslar SP, Lamberti JJ, Connoly DM, and Bichell DP. Surgical
approaches to pacemaker pocket: Does pocket location affect lead
survival? Abstract P05-115, HRS Scientific Sessions, San Francisco, CA,
May 16, 2008.
Kurio G, Frazer JR, Bichell DP, Lamberti JJ, Ing FF. Intra-operative Angiography
and Stent Implantation: Collaboration between the surgeon and the
interventionalist in the management of congenital heart disease. SCAI
28th Annual Scientific Sessions, Ponte Vedra Beach, FL, May 4-7, 2005
Boramanand NK, Goya G, Bichell DP, Perry JC. Atrial Leads in the
postoperative congenital heart patient: Long term benefits of a transmural
approach. NASPE San Francisco May, 2004.
Perry J, Boramanand N, Lamberti J, Maginot K, Bichell D. Atrial
tachycardias following surgical approach to presumed tachycardia
substrates during Fontan revision in young adults. NASPE, New York,
2003
Mathewson JW, Ing FF, Bichell DP. Absent Posterior-Inferior and AnteroSuperior Atrial Septal Defect Rims: Implications for Non-Surgical Closure
of Large Secundum Defects Using the Amplatzer Occluder. SCAI
Scientific Sessions, Boston, May, 2003.
Bichell DP, Lamberti JJ, Cocalis MW, Ing FF and Jensen RA. Late
pulmonary artery stenosis after the Norwood procedure is prevented by a
modification in shunt construction. AHA Scientific Sessions November
2002, Chicago, Illinois.
Mainwaring RD, Uzark K, Bichell DP and Lamberti JJ. Hemi-Fontan versus
cavopulmonary shunt: mid-term follow-up and evaluation of sinus node
function. Circulation 2001, 104(17 Suppl II):II-710.
Jahangiri M, Zorakowski D, Bichell D, Mayer J, del Nido P and Jonas R.
Improved results with selective management in pulmonary atresia with
intact ventricular septum. AATS 1999, New Orleans.
Bichell DP, Jenkins K and Mayer JE. Results of a combined catheter and
surgical strategy for the treatment of multiple ventricular septal defects.
Circulation 1998, 98(17 Suppl I):I-548.
Duncan BW, Atz AM,Bohn DJ, Benson LN, Bichell DP, Jonas RA, French JW,
Black MD and Wessel DL. Mechanical circulatory support for pediatric
patients with acute myocarditis. Circulation 1998, 98(17 Suppl I):I-116-I117.
Bichell DP, Mayer JE, Geva T, del Nido PJ. Minimal access approach for the
repair of atrial septal defect: Experience with the initial 96 patients.
Circulation 1998, 98(17 Suppl I):I-687.
del Nido PJ, Geva T, McGowan FX and Bichell DP. Minimal access
surgery for the correction of complex congenital defects. Circulation
1998, 98(17 Suppl I):I-687.
Visconti KJ, Bichell DP, Jonas RA, Newburger JW and Bellinger DC.
Developmental outcome after surgical versus interventional closure of
ASD in children. Circulation 1998, 98(17 Suppl I):I-340.
Bichell DP, Kikuchi K and Rotwein P. Growth Hormone rapidly induces
Insulin-like Growth Factor-I gene transciption in vivo. Meeting of the
American Society of Clinical Investigators, 1992, Baltimore, MD.
Reviews and Chapters:
Bichell DP, Christian KG. Atrial Septal Defect and Cor triatriatum. Chapter
114, In: Sabiston & Spencer: Surgery of the Chest, 8 th ed., Selke FW, del
Nido PJ, Swanson SJ, eds. Philadelphia, 2010, Elsevier Science.
Graham Jr. TP, Markham L, Parra DA, Bichell D. Congenitally corrected
transposition of the great arteries: An update. Curr Treat Options
cardiovasc Med 2007;9:407-13.
Bichell DP. Pulmonary atresia with intact ventricular septum. In:
Critical Heart Disease in infants and Children, 2nd edition, Nichols DG, ed.,
New York, 2006 Harcourt Publ.
Bichell DP. Atrial septal defect and cor triatriatum. Chapter 10, In:
Sabiston & Spencer: Surgery of the Chest, 7th ed., Selke FW, del Nido PJ,
Swanson SJ, eds. Philadelphia, 2004, Elsevier Science.
Bichell DP. Palliative procedures: shunts and pulmonary artery banding.
In: Operative Cardiac Surgery, Rob & Smith 5th ed., Spray TL and Gardner
TJ, eds. London, 2004, Arnold Publ.
Maginot KR, Mathewson JW, Bichell DP, Perry JC. Applications of pacing
strategies in neonates and infants. Progress in Pediatric Cardiology
2000;11:65-75.
Bichell DP. Pulmonary atresia, intact ventricular septum: Evaluation and
management. Current Opinion cardiol 1999, 14(1):60-66.
Bichell DP. Surgical Procedures. In: Washington University Manual of
Surgery. Little, brown & Company, Boston, 1996.
Rotwein P, Thomas MJ, Gronowski AM, Bichell DP and Kikuchi K. The
somatamedin hypothesis revisited: Early events in Growth Hormone
action. In: Baxter RC, Gluckman PC and Rosenfeld RG, ed. Insulin-like
Growth Factors and their regulatory proteins, Elsevier Science, 1994, p1321.
Books:
Shipman P, Walker A and Bichell D. The Human Skeleton. Cambridge:
Harvard University Press, 1986.
Illustrations (books):
Flye MW (ed): Atlas of Organ transplantation. Philadelphia: WB Saunders, Inc.,
1994. (386 drawings).
Shipman P, Walker A and Bichell D. The Human Skeleton. Cambridge:
Harvard University Press, 1986. (122 drawings).
Becker R and Seldon G. The Body Electric. New York: William Morrow, Inc.,
1985. (87 drawings).
Shipman P. Life History of a Fossil. Cambridge: Harvard University Press,
1981. (16 drawings).
Illustrations (other):
Sundt T. Heart-lung transplantation. In: Mastery of Thoracic Surgery. Boston:
Little, Brown & Company, 1998. (11 drawings).
Spray T, Mallory G, Carter C and Huddleston C. Pediatric lung
transplantation; Indications, technique and early results. J Thorac
Cardiovasc Surg 1994, 107:990-1000.
Robbins M and Joanny J. Contact angle hysteresis on random surfaces.
Europhysics Letters 1987, 3:729-35.
Rose K and Rensberger J. Upper dentition of ekgmowechashala (omomyid
primate) from the John Day formation, oligomyocene of Oregon. Folia
Primatalogica 1983, 41:102-11.
Rose K and Emry R. Extraordinary fossorial adaptations in the oligocene
palaeanodonts epicotherium and xenocranium (mammalia). J Morphology
1983, 175:33-56.
Rose K. Skeleton of Diacedesis, oldest known artiodactyl. Science 1982,
216:621-3.
Rose K and Brown T. New plesiadapiform primates from the eocene of
Wyoming and Montana. J Vertebrate Paleontology 1982, 2:63-9.