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Name
King, Chwan-Chuen (金傳春)
Gender
Female (女性)
Organization
Organization Name:
National Taiwan University, College of Public Health (台大公衛學院)
URL: http://homepage.ntu.edu.tw/~epidem/
Address: 17 Xu-Zhou Road, Taipei, Taiwan (100)
Telephone
8862-3366-8034
Email
[email protected]
Keywords
(1) Infectious disease epidemiology,
(2) surveillance of infectious disease,
(3) pathogenesis of dengue/dengue hemorrhagic fever,
(4) interspecies transmission of influenza,
(5) climate and infectious diseases,
specifying the
expertise
(6) evaluation of vaccine and public health policy for viral diseases
Description
of research
activity
S&T
Publications
/Patents
*
Corresponder
1) Improvement in surveillance of infectious diseases considering climate factor and
epidemiological characteristics
2) Molecular epidemiology of dengue and influenza viruses
3) Immunological evaluation of vaccine and immunopathogenesis of viral diseases
4) Integration of surveillance, epidemiological attributes, microbiological findings to
improve public health policies
5) Ecology and evolution of influenza virus during transmission among different host
species
Chan, Ta-Chien, Hsiao CH K, Lee CC, Chiang PH, Kao CL, Liu CM, and King
Chwan-Chuen* (2010) The Impact of Matching Vaccine Strains and Post-SARS Public
Health Efforts on Reducing Influenza-Associated Mortality among the Elderly. PLoS
ONE 5(6): e11317.
<http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011317>
Chan, Ta-Chien, King Chwan-Chuen, Yen MY, Chiang PH, Huang CS, and Hsiao CH K.
(2010) Probabilistic daily influenza-like illness (ILI) Syndromic Surveillance with a
Spatio-temporal Bayesian Hierarchical Model. PLoS ONE 5(7): e11626.
<http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011626>
Shang, Chuin-Shee, Fang CT, Liu CM, Wen TH, Tsai KH, and King Chwan-Chuen* (2010)
The Role of Imported Cases and Favorable Meteorological Conditions in the Onset
of Dengue Epidemics. PLoS Neglected Trop. Dis. (in press).
Wen TH, Lin N, Chao DY, Hwang KP, Kan CC, Lin KC-M, Wu JT-S, Huang SY-J, Fan IC and
King CC* (2010) Spatial-Temporal Preconditions for a Large-scale Dengue
Epidemic and the Emergence of the Dengue Hemorrhagic Fever in Kaohsiung,
Taiwan. International J. Infectious Disease. International Infectious Disease. Journal
14(4):e334-43.
Wang TE, Lin CY, King Chwan-Chuen, Lee WC (2010) Estimating Pathogen-specific
Asymptomatic Ratios. Epidemiology. June 25.
Yen MY*, Wu TS, Chiu AW, Wong WW, Wang PE, Chan TC, King CC*.(2009) Taipei's use
of a multi-channel mass risk communication program to rapidly reverse an epidemic
of highly communicable disease. PLoS One. 2009 Nov 23;4(11):e7962.
<http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007962>
Huang JW, King CC, Yang JM*.(2009) Co-evolution positions and rules for antigenic
variants of human influenza A/H3N2 viruses. BMC Bioinformatics. 2009 Jan 30;10
Suppl 1:S41.
Tipayamongkholgul M, Fang CT*, Klinchan S, Liu CM, King CC* (2009). Effects of the El
Niño-southern oscillation (ENSO) on dengue epidemics in Thailand, 1996-2005.
BMC Public Health. 2009 Nov 20;9:422.
Lu HM, Chen H, Zeng D, King CC, Shih FY, Wu TS, Hsiao JY. (2009) Multilingual chief
complaint classification for syndromic surveillance: An experiment with Chinese
chief complaints. Int J Med Inform. 78(5):308-20
Chen HL, Lin SR, Liu HF, King CC, Hsieh SC, Wang WK (2008) Evolution of dengue virus
type 2 during two consecutive outbreaks with an increase in severity in southern
Taiwan in 2001-2002. Am J Trop Med Hyg. 2008 Oct;79(4):495-505.
Kan, Chih-Chun, Pei-Fen Lee, Tzai-Hung Wen, Chuin-Shee Shang, Neal H. Lin, Min-Huei
Wu, Day-Yu Chao, Scott Yan-Jang Huang, I-Chun Fan, Pei-Yun Shu, Jyh-Hsiung
Huang, and Chwan-Chuen King* and Lu Pai (2008) Two Clustering Diffusion
Patterns Identified from the 2001-2003 Dengue Epidemic, Kaohsiung, Taiwan.
American J. Trop. Med. and Hyg. Sep; 79(3):344-52（SCI）
Wu, Tsung-Shu, Fuh-Yuan Shih, Muh-Yung Yen, Jiunn-Shyan Julian Wu, Shiou-Wen Lu,
Kevin Chi-Ming Chang, Chao Hsiung, Jr-How Chou, Yu-Tseng Chu, Hang Chang,
Chan-Hsien Chiu, Fu-Chiang Richard Tsui, Michael M. Wagner, Ih-Jen Su and
Chwan-Chuen King* (2008) Establishing a nationwide emergency-department
Syndromic Surveillance System for better public health responses in Taiwan BMC
Public Health 8:18.
King, Chwan-Chuen*, Day-Yu Chao, Tzai-Hung Wen, Chuan-Liang Kao, Chia-Chi Ku,
Joseph Tsung-Shu Wu, Scott Yen-Jang Huang, Mathuros Tipayamongkholgu,
Chuin-Shee Shang, Yi-Shuan Li, Huei-Ting Wang, Mei-Yin Liao, Wei-Kung Wang,
Han-Chung Wu, and Jeff KJ Chang (2008) Epidemiologic Characteristics of Dengue in
Taiwan and Implications for Global Control. A Review Chapter 1, In Book on
“Dengue”, Research Signpost, Kerala, India .
King CC, Chao DY, Chien LJ, Chang GJ, Ling TH, Wu YC, Huang JH.(2008) Comparative
analysis of full genomic sequences among different genotypes of dengue virus type
3. Virol J. 2008 May 21;5(1):63.
Hui-Ling Chen, Su-Ru Lin, Hsin-Fu Liu, Chwan-Chuen King, Szu-Chia Hsieh,and
Wei-Kung Wang* (2008) Evolution of Dengue Virus Type 2 during Two Consecutive
Outbreaks with an Increase in Severity in Southern Taiwan in 2001–2002. Am. J.
Trop. Med. Hyg., 79(4): 495–504
Lai CY, Tsai WY, Lin SR, Kao CL, Hu HP, King CC, Wu HC, Chang GJ, Wang WK.(2008)
Antibodies to envelope glycoprotein of dengue virus during the natural course of
infection are predominantly cross-reactive and recognize epitopes containing highly
conserved residues at the fusion loop of domain II. J Virol. 2008 Apr 30
Chao YC, Huang CS, Lee CN, Chang SY, King CC, Kao CL (2008) Higher Infection of
Dengue Virus Serotype 2 in Human Monocytes of Patients with G6PD Deficiency.
PLoS ONE. 2008 Feb 13;3(2):e1557
<http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001557>
Sun, Der-Shan, Chwan-Chuen King, Yung-Luen Shih, Chin-Cheng Lee, Kuo-An Yeh,
Pei-Hsun Ho, Huey-Fen Shyu, Rong-Hwa Shyu, Wei-Hern Tsai, Teng-Yi Wang, and
Hsin-Hou Chang (2007) Antiplatelet autoantibodies elicited by dengue virus
nonstructural protein NS1 cause thrombocytopenia and mortality in mice. Journal
of Thrombosis and Haemostasis (impact factor 5.138) 5(11):2291-9.
Liu CM*, Lin SH, Chen YC, Lin KC, Wu TS, King CC* (2007) Temperature Drops and the
Onset of Severe Avian Influenza A H5N1 Virus Outbreaks. PLoS ONE. 2007
Feb 7;2:e191.(inter-disciplinary research)
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0000191
Shih FY, Yen MY, Wu JS, Chang FK, Lin LW, Ho MS, Hsiung CA, Su IJ, Marx MA, Sobel H,
King CC* (2007) Challenges faced by hospital healthcare workers in using
a syndrome-based surveillance system during the 2003 outbreak of severe
acute respiratory syndrome in Taiwan. Infect Control Hosp Epidemiology
2007 Mar;28(3):354-7.
Kung CM, King CC, Lee CN, Huang LM, Lee PI, Kao CL. Differences in replication
capacity between enterovirus 71 isolates obtained from patients with encephalitis
and those obtained from patients with herpangina in Taiwan. J Med Virol.
2007 Jan;79(1):60-8.
Chen YC, Huang HN, Lin CT, Chen YF, King CC, Wu HC. Generation & characterization
of monoclonal antibodies against dengue virus type 1 for epitope mapping
and serological detection by epitope-based peptide antigens. Clin Vaccine
Immunol. 2007 Apr;14(4):404-11. Epub 2007 Feb 7.
Hsieh YH, King CC, Chen CW, Ho MS, Hsu SB, Wu YC (2006). Impact of quarantine on
the 2003 SARS outbreak: a retrospective modeling study. J Theor Biol. 2007
Feb 21;244(4):729-36. Epub 2006 Sep 16
Wen TH, Lin NH, Lin CH, King CC, Su MD. Spatial mapping of temporal
risk characteristics to improve environmental health risk identification: a case
study of a dengue epidemic in Taiwan. Sci Total Environ. 2006
Aug 31;367(2-3):631-40. 2006 Apr 11.
Wang WK, Chen HL, Yang CF, Hsieh SC, Juan CC, Chang SM, Yu CC, Lin LH, Huang
JH, King CC. (2006) Slower rates of clearance of viral load and viruscontaining immune complexes in patients with dengue hemorrhagic fever.
Clin Infect Dis. 2006 Oct 15; 43(8):1023-30. Epub 2006 Sep 14.
King, Chwan-Chuen* (2006) Introspection, Counterplot, and Future Strategic
Planning after Epidemics of Infectious Diseases in Taiwan - For the Celebration
of the 21st Anniversary of the Epidemiology Bulletin, Epidemiology Bulletin 22(5)
: 127-147, Taiwan-Center for Disease Control, Dept. of Health.
Ho MS, Chen WJ, Chen HY, Lin SF, Wang MC, Di J, Lu YT, Liu CL, Chang SC, Chao CL,
King CC, Chiou JM, Su IJ, Yang JY . Neutralizing antibody response and SARS
severity. Emerg Infect Dis. 2005 Nov;11(11):1730-7.
Chao DY, King CC*, Wang WK, Chen WJ, Wu HL, Chang GJ. Strategically examining
the full-genome of dengue virus type 3 in clinical isolates reveals its
mutation spectra. Virol J. 2005 Aug 24;2:72.
Hsieh Y-H, King C-C, Chen CWS, Ho M-S, Lee J-L, Liu F-C, et al. (2005) Quarantine
for SARS, Taiwan. Emerg. Infect Dis.11(2):278-282.
Kao CL, King CC, Chao DY, Wu HL, Chang GJ (2005). Laboratory diagnosis of
dengue virus infection: current and future perspectives in clinical diagnosis
and public health. J Microbiol Immunol Infect. 2005 Feb;38(1):5-16.
Wu, Tsung-Shu, Yu-Tseng Chu, Chwan-Chuen King* (2005)
Syndromic Surveillance –Early detection of unexpected infectious disease
outbreaks (Review Article), Epidemiology Bulletin, Center for Disease Control
in Taiwan. (May Taiwan- CDC.
Chao, Day-Yu, Ting-Hsiang Lin, Kao-Pin Hwang, Jyh-Hsiung Huang, Ching-Chuan Liu,
and Chwan-Chuen King* (2004) 1998 Dengue Hemorrhagic Fever Epidemic in
Taiwan Emerg. Infect Dis. 10(3):552-554.
Lin SR, Hsieh SC, Yueh YY, Lin TH, Chao DY, ChenWJ, King CC, Wang WK. (2004) Study
of sequence variation of dengue type 3 virus in naturally infected mosquitoes
and human hosts: implications for transmission and evolution. J
Virol. 78(22):12717-21.
Hung, Jan-Jong, MT Hsieh, MJ Young, CL Kao, Chwan-Chuen King, and Wen
Chang (2004) An external loop region of domain II of dengue virus type 2 envelope
protein is involved in serotype-specific binding to mosquito but not mammalian cells.
J. Virol. 78(1):378-388
Liao, YJ, Tsai CP, Cheng MC, Kao CL, N. Cox, King CC* (2004) Human influenza
surveillance in high risk areas with animal flu epidemics and China visitors. Book
on “Option for Control of Influenza V”, Excerpta Medica, p402-406.
King, Chwan-Chuen*, F. Shih, M. Yen, F. Hu, J. Wu, F. Chang, L. Lin, J. Yang, H. Chen,
T.Wu, D.Wang, K. Chen, H. Yu, H. Chao, S. Lu, C. Chang, S. Lin, C. Fu, C. Huang, M.
Ho, H. Chang, J. Chou, S. Twu, I. Su, M. Marx, H. Sobel (2004) Syndromic
Surveillance of Infectious Diseases in Taiwan - Before and After the Challenges of
Severe Acute Respiratory Syndrome (SARS). MMWR Vol 53, No SU01;245.
Frank Fuh-Yuan Shih, M. Yen, F. Chang, L. Lin, J. Wu, C. Hsiung, M. Ho, I. Su, M. Marx,
H. Sobel, C.C. King* (2004) Evaluation of Taiwan’s Syndromic Surveillance System
after the Severe Acute Respiratory Syndrome — Taiwan, 2003. MMWR Vol 53, No
SU01;258
King, Chwan-Chuen*, YJ LIao, MC Cheng, CP Tsai, TSWu, CL Kao, CH Lin, SC Chiou,
DP Liu, SJ Twu, IJ Su, N Cox, R.G.Webster (2004) Influenza pandemic plan:
Integrated wild bird/domestic avian/swin/human flu surveillance systems in
Taiwan. .Book on “Option for Control of Influenza V”, Excerpta Medica,
p407-412.
Wang WK, Chao DY, Lin SR, King CC, Chang SC (2003) Concurrent infections by two
dengue virus serotypes among dengue patients in Taiwan. J Microbiol Immunol
Infect. 2003 Jun;36(2):89-95.
Wang WK, Chao DY, Kao CL, Wu HC, Liu YC, Li CM, Lin SC, Ho ST, Huang JH, King CC
(2003) High levels of plasma dengue viral load during defervescence in patients
with dengue hemorrhagic fever: implication for pathogenesis. Virology. 2003 Jan
20;305(2):330-8.
Wang WK, Sung TL, Lee CN, Lin TY, and King CC (2002) Sequence diversity of the capsid
gene and the nonstructural gene NS2B of dengue-3 virus in vivo. Virology Nov
10;303(1):181-91.PMID: 12482670
Chang LY, King CC, Hsu KH, Ning HC, Tsao KC, Li CC, Huang YC, Shih SR, Chiou ST, Chen
PY, Chang HJ, Lin TY. (2002) Risk factors of enterovirus 71 infection and associated
hand. Foot, and mouth disease/herpangina in children during an epidemic in
Tiawan. Pediatrics. 109(6):e88
Wang WK, Lin ST, Lee CM, King CC, Chang SC (2002) Dengue type 3 virus in plasma is a
population of closely related genomes: quasispecies. J Virol. 2002
May;76(9):4662-5
Chen YC, Wang SY, King CC (1999). Bacterial lipopolysaccharide inhibits dengue virus
infection of primary human monocytes/macrophages by blockade of virus entry
via a CD14-dependet mechanism. J Virol. 1999 Apr;73(4):2650-7.
Chen WJ, Chen SL, Chien LJ, Chen CC, King CC, Harn MR, Hwang KP, Fang JH.
(1996) Silent transmission of the dengue virus in southern Taiwan. Am J Trop
Med Hyg. 1996 Jul;55(1):12-6.
King CC, Jamieson BD, Reddy K, Bali N, Concepcion RJ, Ahmed R. (1992) Viral
Infection of the Thymus. J Virol. 1992 May;66(5):3155-60.
Ahmed R, King CC, Oldstone MB. (1987) Virus-lymphocyte interaction: T cells of the
helper subset are infected with lymphocytic choriomeningitis virus during
persistent infection in vivo. J Virol. 1987 May;61(5):1571-6.
King CC, King MW, Garry RF, Wan KM, Ulug ET, Waite MR (1979) Effect of
incubation time on the generation of defective-interfering particles during undiluted
serial passage of Sindbis virus in Aedes albopictus chick cells. Virology. 1979 Jul
15;96(1):229-38.
2.3-3: Potentially new and re-emerging epidemics
Research
2.3.3-1: Identification of factors promoting the emergence of pathogens with human
Topics of
pandemic potential from pathogens with a zoonotic background and
Interest (Please
related prevention strategies
see WP 2011)
2.3.3-2: Comprehensive control of Dengue fever under changing climatic conditions
e.g.
HEALTH.2011.2.
3.1-3
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