Download Papers in refereed journals

Publications
Papers in refereed journals
1. Parissenti, A.M. & Coukell, M.B. (1986) Relationship of the cGMP-binding activity to
the cGMP-specific phosphodiesterase in Dictyostelium discoideum. Biochem. Cell Biol.
64:528-534.
2. Parissenti, A.M. & Coukell, M.B. (1989) Identification of a nucleic acid-regulated
cyclicGMP-binding activity in Dictyostelium discoideum. J. Cell Sci. 92:291-301.
3. Parissenti, A.M. & Coukell, M.B. (1990) Effects of DNA and synthetic
oligodeoxyribonucleotides on the binding properties of a cGMP-binding protein from
Dictyostelium discoideum. Biochim. Biophys. Acta 1040: 294-300.
4. Riedel, H., Parissenti, A.M., Hansen, H., & Su, L-H. (1993) Stimulation of calcium
uptake in Saccharomyces cerevisiae by bovine protein kinase C alpha. J. Biol. Chem.
268:3456-3462.
5. Parissenti, A.M., Parker, K., & Schimmer, B.P. (1993) Identification of promoter
elements in the mouse 21-hydroxylase (Cyp21) gene that require a functional cAMPdependent protein kinase. Molec. Endocrinol. 7:283-290.
6. Su, L-H., Parissenti, A.M., & Riedel, H. (1993) The functional carboxy terminal
deletion map of protein kinase C alpha. Receptors and Channels 1:1-9.
7. Riedel, H., Hansen, H., Parissenti, A.M., Su, L-H., Shieh, H.L. & Zhu, J. (1993)
Phorbol ester activation of functional protein kinase C beta-I causes a phenotype in yeast.
J. Cell. Biochem. 52:320-329.
8. Parissenti, A.M., Su, L-H., & Riedel, H. (1993) Reconstitution of protein kinase C
alpha function by the protein kinase C beta-I carboxyl terminus. Mol. Cell. Endocrinol.
98:9-16.
9. Parissenti, A. M., Kim, S. A., Snihura, A., Colantonio, C. M. & Schimmer, B. P.
(1996)The regulatory domain of human protein kinase C alpha dominantly inhibits protein
kinase C beta- regulated growth and morphology in Saccharomyces cerevisiae. J. Cell.
Physiol. 166:609-617.
10. Parissenti, A. M., Kirwan, A. F., Kim, S. A., Colantonio, C. M. & Schimmer, B. P.
(1996) Molecular strategies for the dominant inhibition of protein kinase C. Endocrine
Res. 22:621-630.
11. Parissenti, A. M., Kirwan, A. F., Colantonio, C. M., Kim, S. A. and Schimmer, B.
P.(1998) Inhibitory properties of the regulatory domains of human protein kinase C alpha
and mouse protein kinase C epsilon. J. Biol. Chem. 273: 8940-8945.
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Publications
12. Parissenti, A. M., Villeneuve, D., Kirwan-Rhude, A. F. and Busch, D. (1999). A
carbon source-dependent regulation of cell growth by murine PKC epsilon expression in
Saccharomyces cerevisiae. J. Cell. Physiol. 178:216-226.
13. Parissenti, A. M., Gannon, B. R., Villeneuve, D. J., Kirwan-Rhude, A. F., Chadderton,
A. and Gluck, S. (1999) Lack of modulation of MDR1 gene expression by dominant
inhibition of cAMP-dependent protein kinase in doxorubicin-resistant MCF-7 breast
cancer cells. Int. J. Cancer 82:893-900.
14. Chadderton, A., Villeneuve, D. J., Gluck, S. Kirwan-Rhude, A. F., Gannon, B. R., and
Parissenti, A. M. (2000) Role of specific apoptotic pathways in the restoration of
paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer
cells. Breast Cancer Res. Treat. 59:231-244.
15. Leinweber, B., Parissenti, A. M., Kirwan-Rhude, A. F., Leavis, P. C. and Morgan, K.
G. (2000) Regulation of PKC by the cytoskeletal protein calponin. J. Biol. Chem. 275:
40329-40336.
16. Bewick, M., Conlon, M., Gerard, S., Lee, H., Parissenti, A. M., Zhang, L., Gluck, S.
and Lafrenie, R. M. (2001) HER-2 expression is a prognostic factor in patients with
metastatic breast cancer treated with a combination of high-dose cyclophosphamide,
mitoxantrone, paclitaxel, and autologous blood stem cell support. Bone Marrow
Transplantation 27: 847-853.
17. Bewick, M., Conlon, M., Parissenti, A.M., Lee, H., Zhang, L., Gluck, S., and Lafrenie,
R.M. (2001) Soluble Fas (CD95) is a prognostic factor in patients with metastatic breast
cancer undergoing high dose chemotherapy and autologous stem cell transplantation J.
Hematother. Stem Cell Res. 10:759-768.
18. Kirwan, A. F., Bibby, A. C., Mvilongo, T., Riedel, H., Burke, T., Millis, S. Z., and
Parissenti, A. M. (2003) Inhibition of PKC catalytic activity by additional regions within
the human PKC alpha regulatory domain lying outside of the pseudosubstrate sequence.
Biochemical J. 373: 571-581.
19. Riedel, H. and Parissenti, A.M. (2003) The use of Saccharomyces cerevisiae to
study structure/function relationships for mammalian protein kinase C isoforms and their
modulators. Methods in Molecular Biology 233: 491-516.
20. Guo, B., Hembruff, S. L., Villeneuve, D. J., Kirwan, A. F. and Parissenti, A. M. (2003)
Potent killing of paclitaxel- and doxorubicin-resistant breast cancer cells by calphostin C
accompanied by cytoplasmic vacuolization. Breast Cancer Res. Treat. 82(2):125-141.
21. Guo, B., Hembruff, S.L., Kirwan, A.F., Blais, D.E., and Parissenti, A.M. (2004) Crossresistance studies of isogenic drug-resistant breast tumor cell lines supports recent
clinical evidence suggesting that sensitivity to paclitaxel may be strongly compromised by
prior doxorubicin exposure. Breast Cancer Res. Treat. 85:31-51.
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Publications
22. Bewick, M., Conlon, M., Lee, H., Parissenti, A.M., Zhang, L., Gluck, S. (2004)
Metastatic Breast Cancer Receiving High-Dose Chemotherapy. Stem Cells Dev.
12(3):281-94.
23. Bewick, M., Conlon, M., Lee, H., Parissenti, A.M., Zhang, L., Gluck, S., Lafrenie,
R.M. (2004) Evaluation of sICAM-1, sVCAM-1, and sE-Selectin Levels in Patients with
Metastatic Breast Cancer Receiving High-Dose Chemotherapy. Stem Cells Dev. 3:28194.
24. Parissenti, A.M., and Villeneuve, D.J. (2004) Invited Review: DNA Microarrays and
their use in investigating the Pharmacogenomics of Drug Response. Current Topics in
Medicinal Chemistry 4 (13):1327-1343.
25. Hembruff, S.L., Villeneuve, D.J. and Parissenti, A.M. (2005) Optimization of real-time
PCR methods for the confirmation of cDNA microarray data. Anal. Biochem; 345 (27:237249)
26. Villeneuve, D.J., Hembruff, S.L., and Parissenti, A.M. (2006) cDNA Microarray
Analysis of Isogenic Paclitaxel- and Doxorubicin-Resistant Breast Tumor Cell Liens
Reveals Distinct Drug-Specific Genetic Signatures of Resistance. Breast Cancer
Research and Treatment 96, 17-39.
27. Kumar, A., Kumar, A., Michael, P., Brabant, D., Parissenti, A.M., Ramana, C.V., Xu,
X., and Parrillo, J.E. (2005) Human Serum from Patients with Septic Shock Activates
Transcription Factors Stat1, IRF1 and NF-kB and induces Apoptosis in Human Cardiac
Myocytes. Journal of Biological Chemistry 280(52):42619-42626.
28. Guo, B., Reed, K. and Parissenti, A.M., (2006) Scanning mutagenesis studies reveal
multiple distinct regions within human protein kinase C alpha regulatory domain important
for Phorbol ester – dependent activation of enzyme. Journal of Molecular Biology 357,
820-832.
29. Parissenti, A.M., Hembruff, S.L., Villeneuve, D.J., Veitch, Z., Guo, B., Eng, J. (2007)
Invited Review: Gene expression profiles as biomarkers for the prediction of
chemotherapy drug response in human tumour cells. Anti-Cancer Drugs 18:499-523.
30. Sprowl, J., Hembruff, S.L., Guo, B.,Villeneuve, D.J., and Parissenti, A.M.
(2007) Changes in Expression of Cell Wall Turnover Genes Accompany Inhibition of
Chromosome Segregation by Bovine Protein Kinase C a Expression in Saccharomyces
Cerevisiae. Cell Biol Int 31, 1160-1172.
31. Reed, K., Hembruff, S.L., Laberge, M.L., Villeneuve, D.J., Côté, G.B., and Parissenti,
A.M. (2008) Hypermethylation of the ABCB1 downstream gene promoter accompanies
ABCB1 gene amplification and increased expression in docetaxel-resistant MCF-7 breast
tumor cells. Epigenetics 3(5), 270-280.
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Publications
32. Hembruff, S.L., Laberge, M., Veitch, Z., Guo, B., Villeneuve, D., Shuart, M.,
Cecchetto, M., and Parissenti, A.M. (2008) “Drug Transporters, Drug Accumulation
Defects and the Temporal Acquisition of Resistance to Anthracyclines and Taxanes in
MCF-7 Breast Tumour cells”. BMC Cancer 8, 318.
33. Hussein, S., Michael, P., Brabant, D., Omri, A., Narain, R., Passi, K., R. V.
Chilakamarti., Parrillo, J.E., Kumar, A., Parissenti, A.M., and Kumar, A. (2009)
Characterization of Human Septic Sera Induced Gene Expression Modulation in Human
Myocytes. Int. J. Clin Exp Med. 2, 131-148.
34. Veitch, Z., Guo, B., Hembruff, S.L., Eng, J.R., MacLean, D.A., Heibein, A.D., Bewick,
A., Cull, S., and Parissenti, A.M. (2009) Induction of Aldoketoreductases IC2 and IC3
and other Drug Dose-dependent Genes Upon Acquisition of Anthracycline Resistance.
Pharmacogenetics and Genomics 6, 477-488.
35. Parissenti, A. M., Chapman, J.W., Kahn, H. J., Guo, B., Han, L., O’Brien, P.,
Clemons, M. P., Jong, R., Dent, R., Fitzgerald, B., Pritchard, K. I., Shepherd, L. E., and
Trudeau, M. E. (2010) Association of low tumour RNA integrity with response to
chemotherapy in breast cancer patients. Breast Cancer Research and Treatment 2, 34756.
36. Reed, K., Poulin, M. L., Yan, L. and Parissenti, A. M. (2010) Comparison of bisulfite
sequencing PCR with pyrosequencing for measuring differences in DNA methylation.
Analytical Biochemistry 1, 96-106.
37. Reed, K. and Parissenti, A. (2010) Epigenetic Regulation of ABCB1 Transporter
Expression and Function. Current Pharmacogenomics and Personalized Medicine, 8(3):
218-231.
38. Reed, K. and Parissenti, A. (2011) The Effect of ABCB1 Genetic Variants on
Chemotherapy Response in AIDS and Cancer Treatment. Pharmacogenomics, invited
review (accepted).
39. Hollerman, A., Chung, I., Olsen, R.R., Kwak, B., Mizokami, A., Saijo, N., Parissenti,
A., Duan, Z., Voest, E.E., and Zetter, B.R. (2011) miR-135a contributes to paclitaxel
resistance in tumor cells both in vitro and in vivo. Oncogene E-pub ahead of print
Book Chapters
1. Riedel, H. and Parissenti, A.M. Yeast as a host to screen for modulators and
regulatory regions of mammalian protein kinase C isoforms. Methods in Molecular
Biology 233, 491-516, Protein Kinase C Protocols (ed. A.C. Newton) Humana Press,
New York, 2003.
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Publications
2. Lisa Falvo, Paul Michael, Danielle Brabant, Marisa Tessier, Marija Tonnos, Xiulong
Xu, Chlakamarti V. Ramana, Richard Enelow, Rama Kota, Amadeo M. Parissenti,
Abdelwahab Omri, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Human
Septic Serum Induced Apoptotic Gene Expression Profile in Human Myocytes. Cell
Apoptosis Research Progress, (refereed paper with original data published as a book
chapter) Nova Science Publishers, Editor: Robert H. Fenton, pages 135-152, May
2008.
3. Reed, K. and Parissenti, A. M. (2008) Clusterin-associated signaling pathways
involved in tumor cell drug resistance. Recent Adv. Biochem. Biophys. Res. Research
Signpost 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India, Editors: C.V.
Ramana, Richard I. Enelow and Aseem Kumar
4. Sprowl, J. A. and Parissenti, A. M. (2010) Gene Expression Profiles as Preclinical and
Clinical Cancer Biomarkers of Prognosis, Drug Response, and Drug Toxicity.
Biomarkers in Drug Development: A Handbook of Practice, Application and Strategy,
Edited by Michael R. Bleavins, Claudio Carini, Mallé Jurima-Romet, and Ramin
Rahbari, Copyright 2010 John Wiley & Sons, Inc.
The following additional manuscripts are currently submitted for publication or in
preparation:
1. Sprowl, J. A., Hembruff, S. L., Reed, K., and Parissenti, A. M. (2011) Alterations in
tumour necrosis factor signalling pathways are associated with cytotoxicity and
resistance to taxanes: a study in isogenic resistant tumour cell lines., under review,
Breast Cancer Research
2. Heibein, A. D., Guo, B., Sprowl, J. A., Maclean, D. A., and Parissenti, A. M. (2011)
Role of AKRs and Other Doxorubicin Pharmacokinetic Genes in Doxorubicin
Resistance, DNA binding, and Subcellular Localization., under review,
Pharmacogenetics and Genomics.
3. Guo, B., Santi, S., Tam, A., and Parissenti, A. M. (2011) Role of drug sequestration
and autophagy in the acquisition of doxorubicin resistance in MCF-7 breast tumour
cells., in preparation.
4. Guo, B., Hembruff, S. L., Sprowl, J. A. and Parissenti, A. M. (2011) Tesmilifeneinduced autophagy induction and potentiation of doxorubicin cytotoxicity in
doxorubicin-resistant MCF-7 breast tumour cells, in preparation.
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