Download Several ways have been proposed to improve the cariostatic effect of fluoride at low pH

Several ways have been proposed to improve the cariostatic effect of fluoride at low pH. The
demineralization-inhibiting effect of fluoride-releasing bonding materials during orthodontic treatment
was minimal. Derks A, Katsaros C, Frencken JE, van ’t Hof MA, KuipersJagtman AM. Caries-inhibiting
effect of preventive measure during orthodontic treatment with fixed appliances. Caries Res.
2004;38:413–420. As a result, fluoride in combination with antimicrobials has been recommended to
have an additive effect in the prevention of white spot lesions.
MDPB:
12-methacryloyloxydodecylpyridinium bromide is an antibacterial monomer. It has a strong bactericidal
activity against the oral bacteria specifically S.mutans which is the main bacteria causing carious lesions.
MDPB-containing primers have been shown to kill S. mutans in a short period of time after contact and
it also prevents the growth of bacteria on its surface.