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Several ways have been proposed to improve the cariostatic effect of fluoride at low pH. The demineralization-inhibiting effect of fluoride-releasing bonding materials during orthodontic treatment was minimal. Derks A, Katsaros C, Frencken JE, van ’t Hof MA, KuipersJagtman AM. Caries-inhibiting effect of preventive measure during orthodontic treatment with fixed appliances. Caries Res. 2004;38:413–420. As a result, fluoride in combination with antimicrobials has been recommended to have an additive effect in the prevention of white spot lesions. MDPB: 12-methacryloyloxydodecylpyridinium bromide is an antibacterial monomer. It has a strong bactericidal activity against the oral bacteria specifically S.mutans which is the main bacteria causing carious lesions. MDPB-containing primers have been shown to kill S. mutans in a short period of time after contact and it also prevents the growth of bacteria on its surface.