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Comprehensive Examination # 3
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The peak incidence of which of the following diseases is Not in children
Which of the following host defense mechanisms is the most important for preventing
dysentery caused by Salmonella ?
Gastric acid
Esophageal mucosa
Normal flora of the mouth
Salivary enzymes
One of the following organisms project a “ medusa head “ from colonies grown on
blood agar
Clostridium tetani
Bacillus anthracis
Bacillus subtilis
Clostridium botuliunum
This fungal infection is chronic and characterized by slow developmental of
progressive granulomatous lesions that in time induce hyperplasia of epidermal tissue
Each of the following statements concerning rabies and rabies virus is correct, Except
Rabies virus has a lipoprotein envelope and single-stranded RNA as its genome
The virus has a single antigenic type
The incubation period is usually long rather than short
Rabies is an acute infection of the CNS that is almost always fatal
All of the above are correct
The complement system plays a key role in the host defense process. Which
component of this system is the most important in chemotaxis ?
Septicemic shock of gram negative bacilli is triggered by
Immune complexes
A person with an increased susceptibility to viral, fungal and protozoan infection would
be suspected to have a deficiency to which of the following cell types ?
Natural killer cells
B lymphocytes
T lymphocytes
Reported outbreak of diarrhea, hemorrhagic colitis and HUS ( hemolytic uremic
syndrome ) has been attributed to Escherichia coli. The strain linked to this outbreak is
The part of the body where salmonella typhi resides in making a person chronic carrier
Bloody stream
Gall bladder
Urinary bladder
Non-gonococcal urethritis is/are caused by
A. Ureaplasma urealyticum
B. Chlamydia trachomatis
C. Gardnerella vaginalis
All of the above
A and B
The “ best Guess “ of a causative organism is based on the following considerations
A. Site of infection
B. Age of the patient
C. Host factors
D. Mechanical predisposition
All of these
A latent ,measles-like viral infection and presumably a defect in cellular immunity
associated with which of the following ?
Epstein-Barr virus
Creutzfeldt-Jacob disease
Multiple sclerosis
Subacute sclerosing panencephalitis
The human leukocyte antigen ( HLA ) is known to
A. Regulate cell interaction
B. Elicit allograft reactions
C. Unrecognized by cytotoxic T cell
A and B only
B and C only
It is a gram negative , non-motile bacillus that is most commonly isolated from cooling
Legionella pneumophila
Chlamydia pneumonia
Klebsiella pneumonia
Streptococcus pneumoniae
Which of the following statements is incorrect concerning hepatitis C (HCV ) and
hepatitis D ( HDV )?
HCV is an important cause of post-transfusion hepatitis
HDV is a defective virus with an RNA genome and a capsid composed of hepatitis B surface antigen
HDV is transmitted primarily by the fecal-oral route
People infected with HCV commonly become chronic carriers of HCV and are predisposed to
hepatocellular carcinoma
All of the above are correct
The skin and mucous membrane are the most common portal of entry of the following
organisms, except
Yersenia pestis
Francesilla tularensis
Bacillus anthracis
None of the above
Which of the following microorganisms do not produce oxidase ?
Pseudomonas aeruginosa
Yersenia enterocolitica
Vibrio cholera
All of the above produce oxidase
A patient is suspected to have cryptocoocus neoformans disease. Which of the
following findings would be useful in establishing the diagnosis ?
The presence of encapsulated budding cells in spinal fluid
A recent history of travel in the Mississippi river valley
A positive heterophil agglutination test for the presence of antigen
Recovery of an acid-fast organism from patient’s sputum
Common pathogen in surgical prosthetic implants
Staphylococcus epidermidis
Escherechia coli
Klebsiella pmeumoniae
Streptococcus pyogenes
These fungi elaborates the most potent toxin is
Cryptococcus neoformans
Aspergillus flavus
Candida albicans
Sporothrix schenckii
Chlamydia trachomatis may be responsible for all of the various clinical conditions,
Inclusion conjunctivitis
Pneumonitis in the newborn
Lymphogranuloma venereum
None of the above
It is the predominant facultative organism of the large intestines of man and is used as
an index of fecal contamination of water sample
Proteus mirabilis
Escherichia coli
Enterobacter aerogenes
Proteus vulgaris
Pathogenicity involved in tuberculosis can be primarily attributed to which of the
following ?
Cell mediated hypersensitivity
Toxin production of mycobacteria
Specific adhesion sites
Humoral immunity
None of these
The microbe responsible for significant number of urinary tract infection gram positive
bacteria in sexually active young women is
Staphylococcus epidermidis
Streptococcus agalactiae
Staphylococcusu saprophyticus
Staphylococcus aureus
Streptococcus pyogenes
Reaction to poison ivy or poison oak is
A cell-mediated response
An IgE –mediated response
An Arthus reaction
An IgG-mediated response
Diarrhea caused by which of the following agents is characterized by the presence of
fecal leukocytes ?
Campylobacter jejuni
Rota virus
Clostridium perfringens
Enterotoxigenic Escherichia coli
Chickenpox is a common disease of children , cause by which of the following viruses
Varicella virus
Rota virus
None of the above
Bacteria can acquire antibiotic resistance by
A. Mutation
B. Insertion of transposons
C. Acquiring plasmids
All of these
None of these
A child stung bt a bee experience respiratory distress within minutes and lapses into
unconsciousness. This reaction is mediated by
Sensitized T cells
IgG antibody
Igm antibody
IgE antibody
Which of the following statements concerning Corynebacterium diphtheriae is
incorrect ?
C.diphtheriae I s gram positive bacilli that do not form spores
C.diphtheriae which causes disease through elaboration of a potent exotoxin
C.diphtheriae possess irregular swelling at one end that give them the “ club shaped “ appearance
Antitoxin should be used to treat patient with diphtheria
None of the above is incorrect
Which of the following do not described yersenia pestis ?
Yersenia pestis is a gram negative bacilli and grows strictly anaerobe
Yersenia pestis resembles a hair-pin like appearance
Yersenia pestis exhibit bipolar staining
Yersenia pestis is one of the most virulent bacteria
All of the above described yersenia
Which of the following virulence factor is most likely to cause fever and hypotension ?
An anaerobic organism from necrotic wound demonstrate double hemolysis on blood
agar, growth on egg yolk agar; lecithinase ( + ) ; non-motile , but a rapidly spreading
growth pattern on culture. The most likely organism is_____________________
Clostridium pperfringens
Bacillus anthracis
Clostridium defficille
Bacteroides fragilis
Patients with C5 through C9 deficiencies are most likely to be susceptible to the
following infections is
Pneumococcal infection
Fungal infections
Parasitic infections
Meningococcal infection
What are the mechanisms in which complement provide protection, except
None of the above
Which of the following statements is false concerning Treponema ?
T pallidum produces exotoxin that stimulate adenylate cyclase
T pallidum can not be grown conventional laboratory media
Patients infected with T pallidum produce antibodies that react with beef heart cardiolipin
T pallidum are long, slender helically coiled, spiral or corkscrew-shaped bacilli
All of the above are true concerning T pallidum
"A 23 year old male complains of urethral discharge. A gram stain on a specimen of
the discharge which reveal only neutrophils but no bacteria. " Of the following listed,
which one cause the urethral discharge ?
A. Triponema palllidum
B. Chlamydia trachomatis
C. Candida albicans
D. Coxiella burnetti
Which of the following causative agent of pneumonia is typically associated with the
production of currant-jelly sputum ?
Pseudomonas aeruginosa
Chlamydia pneumonia
Streptococcus pneumonia
Klebsiella pneumonia
Which of the following is the best evidence on which to base a decisive diagnosis of
acute mumps disease ?
A positive skin test
A history of exposure to a child with mumps
Orchitis in young adult male
A 4-fold rise in antibody titer to mumps
All of the fungi causes pulmonary diseases, except
Arpergillus fumigatus
Coccidioides immitis
Histoplasma capsulatum
Sporothrix schenckii
Small, motile, non-spore -forming, curved, microaerophilic , gram negative bacilli that
is the most common antecedent cause of GBS ( Guillain Barre Syndrome )
Pasteurella multocida
None of the above
Campylobacter jejuni
Escherichia coli
Helicobacter pylori
What are the major properties of PAI ( Pathogenicity Island ), except have one or
more virulence genes
They are present in the genome of the pathogenic species and also in the non -pathogenic members
They typically have different guanine and cytosine content than the rest of the bacterial genome
They often have genetic instability
None of the above
The following are measures to prevent tetanus, Except
Active immunization
Proper wound care
Prophylactic use of antitoxin
Giving of muscle relaxant and sedative
None of the above
The coagulase test, in which the bacteria cause plasma to clot, is used to distinguish
Streptococcus pyogenes from staphylococcus aureus
Streptococcus pyogenes from enterococcus faecalis
Staphylococcus aureus from staphylococcus epidermidis
Staphylococcus epidermidis from neisseria meningitides
"A 25 year old male develops fever and jaundice. He consulted a physician who finds
blood test for HBs antigen and anti-HBs antibody are negative." Which of the following
additional test is useful to establish that the hepatitis was indeed due to hepatitis B
virus ?
Anti-HBc antibody
Delta antigen
Anti-HBe antibody
HBe antigen
Habitat of this fungi is dry pigeon droppings which serve as reservoirs is
Cryptococcus neoformans
Blastomyces dermatitidis
Aspergillus flavus
Sporothrix schenckii
What is the role of giving antimicrobial agent penicillin in the treatment of tetanus ?
A. Penicillin stops further the production of toxin
B. Penicillin strongly inhibit the growth of clostridium tetani
C. Penicillin may also control associated pyogenic infections
All of the above
A and b
Which of the following best describe herpes simples infection ?
Regional lymphadenopathy maybe painful
The eruption is usually bilateral
The eruptive period is very painful
The lesions are very different from those of varicella
The fungi that causes superinfection in an altered or immunodeficient host ?
Mucor species
Sporothrix schenckii
Aspergillus fumigatus
Geotrichum candidum