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WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption by Yolanda Calle, Gareth E. Jones, Chris Jagger, Karen Fuller, Mike P. Blundell, Jade Chow, Tim Chambers, and Adrian J. Thrasher Blood Volume 103(9):3552-3561 May 1, 2004 ©2004 by American Society of Hematology Organization of actin cytoskeleton in normal and WASp-/- osteoclasts. Yolanda Calle et al. Blood 2004;103:3552-3561 ©2004 by American Society of Hematology Cytoskeletal organization of normal and WASp-/- osteoclasts on glass coverslips. Yolanda Calle et al. Blood 2004;103:3552-3561 ©2004 by American Society of Hematology Cytoskeletal organization of normal and WASp-/- osteoclasts on bone slices. Yolanda Calle et al. Blood 2004;103:3552-3561 ©2004 by American Society of Hematology Increased cell size and number of nuclei per cell in WASp-/- osteoclasts. Yolanda Calle et al. Blood 2004;103:3552-3561 ©2004 by American Society of Hematology Organization of actin filaments in normal and WASp-/- osteoclasts at adhesion points on the substratum. Yolanda Calle et al. Blood 2004;103:3552-3561 ©2004 by American Society of Hematology Expression of eGFP WASp in WASp-null cells results in the reconstitution of the normal organization of the actin cytoskeleton. Yolanda Calle et al. Blood 2004;103:3552-3561 ©2004 by American Society of Hematology Reconstitution of podosomes in WASp-null osteoclasts plated on glass coverslips by expression of eGFP WASp. WASp-null cells were transduced with eGFP (A-F) or eGFP-WASp (GL). Yolanda Calle et al. Blood 2004;103:3552-3561 ©2004 by American Society of Hematology Reconstitution of podosomes in WASp-/- osteoclasts plated on bone slices by expression of eGFP WASp. WASp-null cells were transduced with eGFP (A-F) or eGFP-WASp (G-L). Yolanda Calle et al. Blood 2004;103:3552-3561 ©2004 by American Society of Hematology Reconstitution of normal cell size and number of nuclei of WASp-/- transduced with eGFP-WASp. Yolanda Calle et al. Blood 2004;103:3552-3561 ©2004 by American Society of Hematology Bone resorption in vitro of normal, WASp-null osteoclasts, and WASp-null osteoclasts transduced with eGFP or eGFP-WASp. Yolanda Calle et al. Blood 2004;103:3552-3561 ©2004 by American Society of Hematology WASp-null osteoclasts are defective in bone resorption in vivo. Yolanda Calle et al. Blood 2004;103:3552-3561 ©2004 by American Society of Hematology
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