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A CURRENT OVERVIEW OF IONTOPHORESIS USED IN THE TREATMENT OF T.M. JOINT INFLAMMATION; MYO-FASCIAL PAIN AND TRIGGER POINTS INTRODUCTION Early work by Dr. Louis Gangarosa and Dr. Arthur Jeske proved the validly of using Iontophoresis intra-orally. Their research was primarily directed toward dental related problems such as tooth hypersensitivity. However, early use of Iontophoresis in extra-oral treatment of joint inflammation, myo-fascial pain and trigger points proved to be unpredictable. It is now felt that early equipment, protocols, techniques and procedures developed primarily for the Physical Therapy marketplace were lacking and provided inconsistent results. The study "Degenerative Joint Disease Part 1: Management and Diagnosis Considerations". Dr. Bates et al. states in the section dealing with the management and therapy for the TMJ-DJD patient: "The use of Iontophoresis drug application has proven to be a major advance in the symptomatic care of those patients unable to take the various antiinflammatory medications. This mode of application of anti-inflammatory agents to the painful joint is accomplished by the iontophoretic transport of the agents through the skin surface, and has minimized the need for intra-articular injections of corticosteroid. Although the direct injection has been shown to give relief in the acute phase, studies have indicated that multiple injections into the TMJ are not advisable due to the potential increase of degenerative changes." Iontophoresis has proven to have several advantages over the traditional delivery of drugs (injection; oral medications). These advantages are: 1) Concentration of therapeutic agents at the desired treatment site 2) Minimization of systemic side effects, especially when a vasoconstrictor is used 3) Decrease in tissue trauma 4) Increase in patient acceptance and compliance Current iontophoretic applications are proving to be very beneficial for the Dental practice providing care for patients suffering from T.M.D. Beginning with the study by Drs. Lark and Gangarosa in the April, 1990 issue of CRANIO, the techniques and protocols for iontophoretic applications have been refined to provide consistent, successful results. Subsequent studies, articles and papers: 1) Pharmacological Management of Temporomandibular Joint Disorders and Chronic Head and Neck Pain; Drs. Louis Gangarosa and Parker Mahan (October 1991; CRANIO) 2) Degenerative Joint Disease Part I: Management and Diagnosis considerations; Drs. Robert Bates Jr.; Henry Gremillion; Carol Stewart (October 1993; CRANIO) 3) Electrotherapeutics in the Clinical Management of Head, Neck, Facial Pain and Temporomandibular Joint Disorders; Dr. Gerald Murphy (1992; ANTHOLOGY OF CRANIOMANDIBULAR ORTHOPEDICS, Volume II) Presented by The International College of CRANIOMANDIBULAR Orthopedics 4) Inflammation of the Temporomandibular Joint; Dr. C. Paschal Brooks (October 1993; T.M. Diary); NEWS JOURNAL OF THE AMERICAN ACADEMY OF HEAD, NECK, FACIAL PAIN & ORTHOPEDICS In addition to the above researchers, it would be appropriate to thank the many "Wet Finger Dentists" for their work and effort to refine and improve the protocols and techniques used in today's iontophoretic applications. PlEASE KEEP IN MIND, THE PROTOCOLS, DRUGS AND TECHNIQUES DISCUSSED ON THESE PAGES, WERE DEVELOPED BY THE AUTHORS OF VARIOUS STUDIES AND IN THE FIELD. LIFE/TECH AND LANDMARK MEDICAL CANNOT, BECAUSE OF FDA REGULATIONS, RECOMMEND ANY MEDICATIONS, CHEMICALS OR SUBSTANCES. PREVIEW The practitioner must keep in mind that Iontophoresis combines the technologies of electrical current, pharmacology and anatomy. Each of these technologies contributes to the successful application of Iontophoresis. For instance, "current follows the path of least resistance" this electrical law works both for and against the practitioner. Consider, the lower resistance in the soft tissue of the joint will "allow" the current and hence the drug ion to flow into the joint space. The bony areas around a joint have a higher electrical resistance. This higher resistance will create a soft tissue electrical pathway. But if the treatment area has a skin irregularity (lowered electrical resistance) most of the current would flow through the skin irregularity, and without proper technique, the patient's tissue could conceivably be traumatized. The active or beneficial part of the drug compound must have the highest electrical charge. The current flow has no way of discriminating between "good"(beneficial drug) or "bad" (preservative or non-beneficial) ions. The unit will predominantly push the ion which has the highest electrical charge. For this reason, only certain drugs or brands of drugs are suggested for use with Iontophoresis. The results become more predictable and consistent when the compound of the drug is known. The use of a vasoconstrictor has proven to be of particular vasoconstrictor will temporarily restrict the blood flow in area of treatment and allow for a higher cellular uptake of With no vasoconstrictor the vascular blood flow will "wash" percentage of the drug during treatment. benefit. The the immediate the active drug. away a large The use of a large ground will reduce resistance. This will allow a high current to flow comfortably into the patient's tissue. Comfortable treatment levels (before the anesthesia effect) can often be used as a method to determine the current level best suited to iontophoretic application. PRACTICAL METHODS FOR IONTOPHORETIC APPLICATIONS SECTION ONE 1) Treatment site selection for the TMJ 2) Meditrode(s) selection 3) Skin preparation 4) Meditrode(s) placement and filling 5) Wire and cable selection 6) Review MEDITRODE(S)SITE SELECTION Proper placement of the Meditrode(s) will insure maximum penetration of the drug Ions. For instance, when working with a bony area remember bone is only about 5% electrically conductive as compared to soft tissue being about 80% electrically conductive. Palpate the treatment area not only for centering the electrode over the pi-center of the treatment area but also consider soft tissue pathways for maximum penetration of current and drug to the deeper depths. For example, when treating the T.M.D., place the gauze portion of the Meditrode(s) directly over the Coronoid notch. This will "allow" the current/drug to be pushed into the joint with minimum resistance. When treating patients with a deep recession or hollowed area over the Coronoid notch, it may be necessary to place a small piece of cotton in the recessed area. Press the gauze portion of the Meditrode(s) against the cotton. By filling the hollow, a consistent skin contact is maintained. This procedure will ensure the current/drug flows into the joint space. Remember to increase the amount of liquid in your drug "cocktail". This will ensure there is enough liquid to moisten both the cotton and the Meditrode(s). DUAL MEDITRODE (S) TREATMENT FOR Many times it is very beneficial to drive both JOINTS TMJ joints simultaneously. Keep in mind, lack of conductivity over bone and place Meditrodes over soft tissue pathways, which will deliver the drug into both joint spaces. Remember that the current is not flowing between the two "drug" delivery Meditrodes. During a dual application each Meditrode creates a separate current flow or channel with the "return" electrode. When treating larger joints, the operator should "bracket" the joint by placing Meditrodes on both sides of the joint, allowing soft tissue pathways to deliver the current/drug to deeper depths. MEDITRODE (S) SITE SELECTION FOR Meditrode(s) placement over myo-fascial SOFT TISSUE treatment sites should be palpated to determine AND TRIGGER the epicenter of the painful treatment site. The POINTS Meditrode(s) should be centered over this area. as Trigger points have a lowered electrical resistance most of the current/drug will flow through the trigger point. Do not place Meditrode(s) with the active drug pad of the Meditrode(s) over major blood vessels, because in this placement, a greater portion of the drug ions will "wash" or flow away from the treatment site. When treating sites such as trigger points, keep in mind, using a large Meditrode(s) may be more beneficial than a smaller Meditrode(s) because you will also be treating satellite trigger points and overall myo-fascial soreness and spasm surrounding the selected treatment site. MEDITRODE(S) SIZE SELECTION The size, shape and location of the treatment site should dictate the selection of the Meditrode(s). Also, you must consider if you want to concentrate the drug ions in a small space such as the insertion of a nerve ending or a joint, or are you treating a soft tissue pain/spasm area and its surrounding tissue. Location will determine if you need a Meditrode(s) which will contour to the treatment area. Life/Tech has 6 different size and shape drug delivery Meditrodes. Select a Meditrode(s) which will cover the treatment area and a small margin of tissue surrounding that area. The last consideration is, will the Meditrode(s) pad conform tightly to the treatment site? If not, small pieces of clean cotton balls may be used, to complete skin contact (explained earlier). SKIN PREPARATION OF TREATMENT SITE The treatment site should be thoroughly cleansed with an alcohol pad or warm soapy water. It is Imperative that all makeup and oils are removed from the treatment area. Do not abrade the skin with harsh scrubbing as this will create problems during the actual treatment phase, but the skin must be clean. Oils and makeup add electrical resistance and will decrease conductivity. Also keep in mind that cosmetics may have active ions and would have the potential to be driven into the skin during the treatment phase. Hairy areas can be difficult. Consider, current normally will follow the hair follicle as the path of least resistance. However, if you are dealing with thick hairy areas such as a beard or scalp, there is no way to contour the Meditrode(s) tightly to tissue and skin burns may occur. At the very least, the current sensation will be uncomfortable to the patient because of electrical arcing. VISUALLY INSPECT the treatment site for skin defects such as scars, TREATMENT moles, freckles, enlarged pores or other SITE imperfections which could create a pathway of least resistance, and as such, may create a uncomfortable sensation during treatment. Also if the treatment period is lengthy a skin burn could result from the concentration of current in the small area of the imperfection. An easy method for insulating the skin defect area would be to use a very small amount of Vaseline on the end of a "Q" tip. Lightly touch the skin area with the "Q" tip and Vaseline. If there is a scar, trace the scar with the Vaseline. DO NOT use a large amount of Vaseline or spread the jelly over a large area, as this will prevent or limit the amount of ions passing through this insulated area. REMEMBER as you press the Meditrode(s) in place you will spread the jelly. So please "a little dab will do you". MEDITRODE(S) PLACEMENT After cleaning and inspecting the treatment site, select the proper Meditrode and slightly stretch the Meditrode(s) over the skin. You must ensure complete contact between the skin and the gauze treatment pad to prevent arcing of the current through open air. this arcing could cause an uncomfortable current sensation. Ensure the tape surrounding the medications pad is flat and smooth against the skin, with no puckers or ridges. CONNECTING THE MEDITRODE(S)WIRES before filling the Meditrode(s) connect the wires to the Meditrode(s) snaps. You do this to prevent squeezing the medication out of the Meditrode(s) while connecting the wires after filling. FILLING THE MEDITRODE(S) After mixing the medications and creating the "medication cocktail" ALWAYS REMOVE THE NEEDLE PORTION OF THE SYRINGE before filling the Meditrode(s). This will prevent the inadvertent "sticking" of the patient through the Meditrode(s), thus preventing a problem during the treatment phase. The hub of the syringe is inserted into the medicine port (holes). The Meditrode(s) is filled SLOWLY by depressing the plunger. An eye dropper can be substituted for the syringe. Starting at the uppermost port, fill each of the medicine ports ensuring the Meditrode(s) is completely saturated. The Meditrode(s) is filled when you see a small drop of medication appear at the medicine ports during application. DO NOT OVER FILL as this will cause the tape to lift away from the skin. If lifting does occur, use a piece of tape to "stick" the Meditrode(s) back into complete contact with the skin. SELECTION OF MEDITRODE(S) If a dual treatment is being considered you must use the WIRES red wires connected with the grey grommet. This grommet has a resistor in place which will allow the current to flow evenly to both Meditrodes, regardless of resistance. Of course, if a single site is being treated, then a single red wire is used. Do not attempt to use the dual wire during a single site treatment, remember the unused snap portion of the dual Meditrode(s) wire will still be passing current (if still plugged into the treatment cable) and could burn the patient if the snap remains in contact with the skin. CONNECTING WIRES AND CABLE TO UNIT The treatment cable has two red female connectors marked "drug". Connect either the dual or single Meditrode wire(s) into these red connector(s). The cable also has a black female connector which is marked "return", the black ground or reference wire is plugged into this connector. The unit itself has a connector on the top marked "reference". You may also plug the return wire into this connector. When using the large 5" X 8" ground, plug the attached wire into either or the "return" or " "reference" connector. The circuit will be complete when the drug and return electrodes are attached to the patient and filled with medication. Remember the terms "reference"; "return"; "dispersive" and "ground" are synonymous. However, we avoid the word "ground" because of any harmful electrical connotations the patient may harbor. The treatment cable snaps straight into the unit. Do not attempt to turn or twist the connector into the unit as this will bend the connecting wires within the unit. REVIEW 1) Select either a single or dual treatment site keeping in mind the soft tissue flow or channels into a joint area. Do not place Meditrode(s) over a major blood vessel. 2) Select Meditrode(s) which will contour to the skin and create a slight margin surrounding the treatment site. 3) Cleanse the skin and insulate any imperfections which may be present. 4) Place the Meditrode(s) to ensure complete contact between medication pad and tissue. 5) Fill the Meditrode(s) before connecting the wires. 6) Remove the needle from the syringe before filling the Meditrode(s) to the saturation point. 7) Always select the correct Meditrode wires for a single or dual treatment. DO NOT twist the patient cable connector when connecting unit. A two phase treatment IS NOT the same as a dual treatment. NOTE In a two phase treatment the operator is driving a positive charged drug (lidocaine; vasoconstrictor) and then a negative charged drug (antiinflammatory) during the same treatment to a single application. In a dual treatment, the unit is being used to drive two treatment sites simultaneously with one or more medications. Of course, a two phase treatment is most often used in either a single or dual treatment. For More Information concerning Iontophoresis Please contact Landmark Medical, Inc. ~ 1-800-334-5618 ~ 770-785-7359 Fax 770-785-7495 www.landmarkmedical.com E-mail [email protected]