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A) SENNA:
B) CLASS: LAXATIVE
C) DOSAGE:
1) IMPORTANT NOTE: Dosing of herbal preparations is highly dependent on a variety
of factors, such as growing and harvesting conditions, plant parts and extraction
methods used and the dosage form chosen by the manufacturer. Standardization to
single constituent markers has proven unreliable. Since no official standards have been
established to date to regulate the production of herbal medicines in the United States,
dosage ranges must be employed as guidelines.
2) ADULT:
a) Constipation, oral: 0.5 to 2.0 grams of the crude drug or 20 to 40 milligrams
Sennosides (standardized preparations) with water, ideally at bedtime or as directed by
a physician.
b) Colon evacuation for rectal and bowel examinations: a single dose of 75 milliliters
(mL) of a standardized Senna preparation (1 mL standardized to 26 milligrams
Sennoside B) is recommended.
3) PEDIATRIC:
a) Constipation, oral: the usual recommended sennosides dose for children older than 6
years of age is 20 milligrams with water, ideally at bedtime or as directed by a
physician.
b) Colon evacuation for rectal and bowel examinations: A single dose of 1 milliliter (mL)
per kilogram bodyweight of a standardized senna preparation (1 mL standardized to 26
milligrams Sennoside B) is recommended for children older than 7 months.
D) ADMINISTRATION: Oral
E) HOW SUPPLIED: Tablet, syrup, granules, tea
F) USES:
1) SCIENTIFIC EVIDENCE: Clinical trials support the use of Senna preparations in the
treatment of constipation and for colon evacuation prior to rectal and bowel
examinations. Senna was ineffective as a treatment for fecal soiling. In one adult and
one in vitro study, Senna showed possible effectiveness in the treatment of herpes
simplex. In an in vitro study, Senna showed possible effectiveness in the treatment of E
coli and Candida Albicans.
2) COMPLEMENTARY AND ALTERNATIVE MEDICINE INDICATIONS: The clinical
usefulness of Senna has been limited to its laxative effect in the short-term treatment of
constipation.
G) CONTRAINDICATIONS: Allergies to this herb, chronic laxative abuse, cathartic
colon, bowel obstruction, fecal impaction, acute inflammation of Crohn's disease,
patients with nausea or vomiting, and undiagnosed abdominal pain
H) ADVERSE EFFECTS: Abdominal pain and cramps, diarrhea, melanotic pigmentation
of the colonic mucosa, electrolyte abnormalities, urine discoloration, nephritis, and
laxative abuse
I) DRUG/FOOD INTERACTIONS: Senna should be taken with milk. Senna potentiates
digitalis actions. Indomethacin decreases senna actions.
J) PREGNANCY/LACTATION: Senna is classified as US Food and Drug Administration
Pregnancy Category C. Senna is not excreted into breast milk to a significant degree.
The American Academy of Pediatrics considers senna to be compatible with
breastfeeding.
K) NOTE: The safety profile of herbal medications and dietary supplements is not well
known. Due to the unregulated nature of the supplement industry in the United States, it
is advised to become familiar with manufacturers and their products before
recommending them for safe and effective use. Adulteration has been a recurring
problem.
URL :
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videncexpert/ND_P/evidencexpert/PFActionId/evidencexpert.IntermediateToDocumentLink?docId=10&
contentSetId=60&title=SENNA&servicesTitle=SENNA