Download RESEARCHES AND PUBLICATIONS

RESEARCHES AND PUBLICATIONS
1. Synthesis of Diazen-1ium-1,2-diolates Monitored by the NOtizer Apparatus:
Relation between the Formation Rates, Molecular Structure, and the Release of
Nitric Oxide. J. Konter, G. E. -Din A. A. Abuo-Rahma, A. A. El-Emam and J.
Lehmann. Eur. J. Org. Chem. 2007, 616-624.
2. Microwave-Assisted Dehydrosulphurization: An Efficient, Solvent-free Synthesis
of 5-(1-Adamantyl)-2-arylamino-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. E. S. AlAbdullah, I. A. Shehata, O. A. Al-Deeb and A. A. E-Emam, Heterocycles 71,
379-388 (2007).
3. Synthesis, Antimicrobial, and Anti-inflammatory Activities of Novel 2-(1Adamantyl)-5-substituted-1,3,4-oxadiazoles and 2-(1-Adamantylamino)-5substituted-1,3,4-thiadiazoles. A. A. Kadi, N. R. El-Brollosy, O. A. Al-Deeb, E. E.
Habib, T. M. Ibrahim and A. A. El-Emam. Eur. J. Med. Chem. 42, 235-242
(2007).
4. Synthesis of Novel uracil non-nucleosides analogues of 3,4-dihydro-2-alkylthio-6benzyl-4-oxopyrimidines and 6-benzyl-1-ethoxymethyl-5-isopropyluracil. N. R.
El-Brollosy, M. A. Al-Omar, O. A. Al-Deeb, A. A. El-Emam and C. Nielsen. J.
Chem. Res. 2007, 236-267.
5. Fluorimetric Determination of Nilvadipine in Pharmaceuticals and Biological
Fluids via Reduction using zinc/HCl. A A. El-Emam, F. F. Belala, M. A.
Moustafa, S. M. El-Ashry and D. T. El-Sherbiny. Curr. Topics Anal. Chem. 6, 1118 (2006).
6. Synthesis, Antimicrobial, and Anti-inflammatory Activities of Novel 2-[3-(1Adamantyl)-4-substituted-5-thioxo-1,2,4-triazolin-1-yl]acetic Acids, 2-[3-(1Adamantyl)-4-substituted-5-thioxo-1,2,4-triazolin-1-yl]propionic acids and
Related Derivatives. A. A. Al-Deeb, M. A. Al-Omar, N. R. El-Brollosy, E. E.
Habib, T. M. Ibrahim and A. A. El-Emam. Arzneim.-Forsch./Drug Res. 56, 40-47
(2006).
7. NO-Donors, Part 9 [1]: Diazeniumdiolates Inhibit Human Platelet Aggregation
and Induce a Transient Vasodilatation of Porcine Pulmonary Arteries in
Accordance with the NO-Releasing Rates. G. E. -Din A. Abuo-Rahma, A.
Horstmann, M. F. Radwan, A A. El-Emam, E. Glusa and J. Lehmann. Eur. J.
Med. Chem. 40, 281-287 (2005).
8. The NOtizer – a Device for the Convenient Preparation of Diazen-1-ium-1,2diolates. J. Konter, G. Abuo-Rahma, A. A. El-Emam and J. Lehmann. Methods in
Enzymology 396, 17-26 (2005).
7
9. Fluorimetric Measurement of Hydrogen Peroxide Produced During Aldehyde
Oxidase Catalysed Oxidation Using Scopoletin. M. A. Al-Omar, C. Beedham, F.
Belal, J. A. Smith and A. A. El-Emam. J. Med. Sci. 5, 10-20 (2005).
10. 1,3,4-Thiadiazoles: Regioselective Demethylation on Ring Closure of 1-(3,4,5Trimethoxyphenyl)-4-substituted Thiosemicarbazides with Sulphuric Acid. M. AlOmar, O. A. Al-Deeb, H. A. Al-Khamees and A. A. El-Emam. Phosphorus,
Sulfur Silicon Rel. Elem. 179, 2509-2517 (2004).
11. Synthesis, Antimicrobial, and Anti-HIV-1 Activity of Certain 5-(1-Adamantyl)-2substituted thio-1,3,4-oxadiazoles and 5-(1-Adamantyl)-3-substituted
aminomethyl-1,3,4-oxadiazoline-2-thiones. A. A. El-Emam, O. A. Al-Deeb, M.
Al-Omar and J. Lehmann. Bioorg. Med. Chem. 12, 5107-5113 (2004).
12. Synthesis of Certain 6-Substituted Uracils and Related Derivatives as Potential
Antiviral Agents. A. A. El-Emam, M. A. Massoud, E. R. El-Bendary and M. A.
El-Sayed. Bull. Kor. Chem. Soc. 25, 991-996 (2004).
13. Determination of Lisinopril in Dosage Forms and Spiked Human Plasma Through
Derivatization with 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) Followed
by Spectrophotometry or HPLC with Fluorimetric Detection. A. A. El-Emam, S.
H. Hansen, M. A. Moustafa, S. M. El-Ashry and D. T. El-Sherbiny. J. Pharm.
Biomed. Anal. 34, 35-44 (2004).
14. Spectrophotometri Determination of Propranolol via Oxidative Coupling with 3Methylbenzothiazoline-2-one Hydrazone. A. A. El-Emam, F. F. Belal, M. A.
Moustafa, S. M. El-Ashry, D. T. El-Sherbiny and S. H. Hansen. Il Farmaco 58,
1179-1186 (2003).
15. Evaluation of the Use of Microemulsions as eluents in High-Performance liquid
Chromatography. D. T. El-Sherbiny, S. M. El-Ashry, M. A. Moustafa, A. A. ElEmam and S. H. Hansen. J. Separation Sci. 26, 503-509 (2003).
16. Synthesis of Certain 6-(arylthio)uracils as Potential Antiviral Agents. A. A. ElEmam, M. N. A. Nasr, E. B. Pedersen, T. Fouad and C. Nielsen. Phosphorus,
Sulfur Silicon Rel. Elem. 174, 25-35 (2001).
17. Synthesis and Antiinflammatory Evaluation of New 2- and 3-Substituted 1,2,4Triazolo[4,3-c] and [1,5-c]Quinazoline Derivatives. M. M. Gineinah, M. N. Nasr,
A. M. Abdelal, A. A. El-Emam and S. A. Said. Med. Chem. Res. 10, 234-252
(2000).
18. Analytical Profile of Tranylcypromine Sulfate. H. Abdel-Aleem, M. B. ElAshmawy, F. Belal, A. A. El-Emam and H. G. Brittain. Monograph in Analytical
Profiles of Drug Substances and Excepients, H. G. Brittain, ed., Academic Press,
New York, Vol. 25, pp. 501-533 (1998).
8
19. Synthesis of Certain 5-Substituted-2-thiohydantoin Derivatives as Potential
Cytotoxic Agents. A. I. Khodair, H. I. El-Subbagh and A. A. El-Emam. Boll.
Chim. Farmaceutico 136, 561-567 (1997).
20. N- And S-Alkylation of 3-(1-Adamantyl)-4-methyl-1,2,4-triazole-5-thiol and 2-(1Adamantyl)-1,3,4-oxadiazole-5-thiol. A. A. El-Emam and J. Lehmann.
Phosphorus, Sulfur Silicon Rel. Elem. 121, 473-474 (1997).
21. Synthesis and Antiinflammatory Activity of Certain Thienopyrimidine
Derivatives. M. M. El-Kerdawy, M. Y. Yousif, A. A. El-Emam, M. A. Moustafa
and M. A. El-Sherbiny. Boll. Chim. Farmaceutico 135, 301-305 (1996).
22. Synthesis of an AZT –HEPT Hybrid and Homologous AzddU Derivatives. E.
Larsen, K. Daniel, G. B. Vaaben, A. A. El-Emam, E. B. Pedersen and C. Nielsen.
Acta Chem. Scand. 50, 417-421 (1996).
23. Synthesis of 2-Alkylthio Analogues of AZT and their Activity Against HIV-1. M.
A. Zahran, A. E. –S. Abdel-Megeid, A. A. Abdel-Rahman, A. A. El-Emam, E. B.
Pedersen and C. Nielsen. Heterocycles 41, 2507-2518 (1995).
24. Synthesis, Antimicrobial and Antiviral Evaluation of Certain Thienopyrimidine
Derivatives. M. A. El-Sherbiny, M. B. El-Ashmawy, H. I. El-Subbagh, A. A. ElEmam and F. A. Badria. Eur. J. Med. Chem. 30, 445-449 (1995).
25. Synthesis of Certain Benzoxazine and Quinoxaline Derivatives as Potential
Antiinflammatory Agents. M. M. El-Kerdawy, M. Y. Yousif, A. A. El-Emam, M.
A. Moustafa and M. A. El-Sherbiny. Egypt. J. Pharm. Sci. 35, 1-20 (1994).
26. Adamantane Derivatives IV: Unexpected Debenzylation on Ring Closure of 1(1Adamantycarbonyl)-4-benzylthiosemicarbazide with Sulphuric Acid. A. A. ElEmam and J. Lehmann. Monatsh. Chem. 125, 587-591 (1994).
27. Glycosylation of 6-Arylthiouracil with 3-Azido-2,3-dideoxypentafuranoside
Derivatives. A. A. El-Emam, E. B. Pedersen, J. P. Jacobsen and C. Nielsen. Bull.
Soc. Chim. France 130, 817-821 (1993).
28. Synthesis and Antimicrobial Testing of 2,3-Disubstituted Cyclopenteno[b]thieno
[2,3-b]-3,4-dihydropyrimidin-4-ones and 2-Arylaminocyclopenteno[b]thieno-[2,3d]-4H-3,1-thiazin-4-ones. M. M. El-Kerdawy, M. Y. Yousif, A. A. El-Emam, M.
A. Moustafa and M. A. El-Sherbiny. Chin. Pharm. J. 45, 475-463 (1993).
29. Triazoles and Fused Triazoles IV: Synthesis of 3-(1-Adamantyl)-6-substitutedstriazolo[
3,4-b][1,3,4]thiadiazoles and 3-(1-Adamantyl)-6-aryl-7H-s-triazolo[3,4b][1,3,4]thiadiazines as Potential Chemotherapeutic Agents. A. A. El-Emam, M.
A. Moustafa, A. M. Abdelal and M. B. El-Ashmawy. Chin. Pharm. J. 45, 101-107
(1993).
30. Thio Nucleoside Derivatives as Intermediate Target in the Attempt of Finding
New Agents Against HIV. E. B. Pedersen, K. L. Ducholm, A. A. El-Emam, A. A.
9
M. El-Torgoman, M. S. Motawia, Y. L. Ali, P. T. Jorgensen, A. A. El-Barbary, A.
Khodair and E. Larsen. Phosphorus, Sulfur Silicon Rel. Elem. 74, 465-466 (1993).
31. Synthesis of Certain Fused 1,3,4-Thiadiazoles and 1,3,4-Thiadiazepines. I. A.
Shehata, M. A. Moustafa, A. M. Abdelal and A. A. El-Emam. Orient. J. Chem. 8,
304-308 (1992).
32. Nucleosides: Synthesis of. Some New Naphthimidazole Ribonucleosides as
Potential Antibacterial Agents. A. M. Abdelal, A. A. El-Emam and M. A.
Moustafa. J. Chin. Chem. Soc. 39, 257-261 (1992).
33. Synthesis and Antibacterial Activity of New 3,4,5-Trimethoxyphenylpyridines. M.
A. Moustafa, A. A. El-Emam and M. M. Meshaly. Chin. Pharm. J. 44, 37-43
(1992).
34. Percentage Deuterium Retained After para-Hydroxylation of (R)-(+)-2HPhenytoin
and para-Hydroxylation of (S)-(-)-2H-Phenytoin in Rats. M. A.
Moustafa, A. A. El-Emam, A. M. Abdelal and M. E. –S. Metwally. Arch. Pharm.
Res. 14, 35-39 (1991).
35. Synthesis Certain N1-[4-Aryl-6-(2-benzofuryl)-2-pyrimidyl]sulfanilamides as
Potential Antibacterial Agents. A. M. Abdelal, M. A. Moustafa, I. A. Shehata and
A. A. El-Emam. Sci. Pharm. 59, 265-274 (1991).
36. Synthesis, Anti-inflammatory and Analgesic Activity of Certain 3-(1-Adamantyl)4-substituted-5-mercapto-1,2,4-triazole Derivatives. A. A. El-Emam and T. M.
Ibrahim. Arzneim.-Forsch./Drug Res. 41, 1260-1264 (1991).
37. Synthesis of 1-Phenyl-1H-Tetrazolo[4,5-d]tetrazole and 5-Aryl-1-(4bromophenyl)-1,2,4-triazolo[4,3-d]tetrazoles. M. A. Moustafa, A. M. Ismaiel, H.
M. Eisa and A. A. El-Emam. J. Chin. Chem. Soc. 38, 199-201 (1991).
38. Fused Pyrimidines: Synthesis of Pyrazolo[3,4-e][1,3,4]thiadiazolo[3,2-
a]pyrimidine and Pyrazolo[4’,3’:5,6]pyrimido[2,1-b]benzothiazole Derivatives.
M. B. El-Ashmawy, I. A. Shehata, H. I. El-Subbagh and A. A. El-Emam. Gazz.
Chim. Ital. 121, 113-115 (1991).
39. Triazoles and Fused Triazoles IV: The Reaction of 3-Aryl-4-amino-5-mercapto1,2,4-triazoles with Chloroacetic Acid, 2-Chloronicotinic Acid, Ethyl
Acetoacetate, Acetyl Acetone and ,-Unsaturated Ketones. A. A. El-Emam.
Sulfur Lett. 12, 201-209 (1991).
40. Comparative Study on the Para-Metabolic Oxidation of Phenytoin and
Decadeuteriophenytoin. M. A. Moustafa, A. A. El-Emam, H. I. El-Subbagh and
M. K. Sharaf El-Din. Arzneim.-Forsch./Drug Res. 40, 1076-1078 (1990).
41. Synthesis of Certain Uracil-6-yl or Tetrazol-5-ylpyrazolin-5-one and Pyrazol
Derivatives as Potential Anti-inflammatory Agents. M. S. Moustafa, H. M. Eisa,
A. A. El-Emam and M. A. Metwally. Arch. Pharm. Res. 13, 204-206 (1990).
10
42. Synthesis of Certain Mercapto- and Aminopyrimidine Derivatives as Potential
Antimicrobial Agents. M. M. El-Kerdawy, H. M. Eisa, A. A. El-Emam, M. A.
Massoud and M. N. Nasr. Arch. Pharm. Res. 13, 142-146 (1990).
43. Synthesis and Biological Activity of Certain 1-Adamantyl Derivatives. A. A. ElEmam. Chin. Pharm. J. 42, 309-315 (1990).
44. Thienobenzothiopyranones III: New 4H-Thieno[2,3-b][1]benzothiopyran-4-ones
Carrying Different Heterocyclic Moieties of Expected Pharmacological Interest.
H. I. El-Subbagh, A. A. El-Emam, M. B. El-Ashmawy and I. A. Shehata. Arch.
Pharm. Res. 13, 24-27 (1990).
45. Triazoles and Fused Triazoles III: Facile and Efficient Synthesis of 2,4Disubstituted-s-triazolo[3,4-b]-1,3,4-thiadiazoles. A. A. El-Emam, M. A.
Moustafa, H. I. El-Subbagh and M. B. El-Ashmawy. Monatsh. Chem. 121, 221225 (1990).
46. Some Reactions of Certain Heterocyclic ,-Unsaturated Ketones. M. M. ElKerdawy, H. M. Eisa, A. A. El-Emam, M. A. Massoud and M. N. Nasr. Orient. J.
Chem. 6, 115-119 (1990).
47. Synthesis of Substituted 4H-Thieno[2,3-b][1]benzothiopyran-4-ones as Possible
Schistosomicidal Agents. M. M. El-Kerdawy, A. A. El-Emam, H. I. El-Subbagh
and E. Abushanab. Monatsh. Chem. 121, 45-50 (1990).
48. Synthesis and Biological Testing of Certain 2-(5-Substituted-2-thienylthio)benzoic Acid Derivatives. A. S. Tantawy, H. I. El-Subbagh, M. B. El-Ashmawy
and A. A. El-Emam. Il Farmaco 44, 1217-1224 (1989).
49. Synthesis of Substituted 4H-Thieno[2,3-b][1]benzothiopyran-4-ones as Potential
Schistosomicidal Agents. H. I. El-Subbagh, M. Y. Yousif, A. A. El-Emam M. M.
El-Kerdawy. Arch. Pharm. Res. 12, 135-137 (1989).
50. Synthesis of Substituted Arylthioxanthones as Potential Schistosomicidal Agents.
M. M. El-Kerdawy, A. A. El-Emam, H. I. El-Subbagh and E. Abushanab. Arch.
Pharm. Res. 12, 5-7 (1989).
51. Synthesis of Substituted Pyrimidines as Possible Schistosomicidal Agents. M. M.
El-Kerdawy, A. A. El-Emam, H. I. El-Subbagh and E. Abushanab. J. Heterocycl.
Chem. 26, 913-915 (1989).
52. Triazoles and Fused Triazoles II: Synthesis of Certain Substituted s-Triazoles, sTriazolo[3,4-b]-1,3,4-thiadiazoles and s-Triazolo[3,4-b]-1,3,4-thiadiazines. A. A.
El-Emam, M. A. Moustafa, S. M. Bayomi and M. B. El-Ashmawy. J. Chin.
Chem. Soc. 36, 353-356 (1989).
53. Synthesis of Substituted 4H-Thiazolo[4,5-b][1]benzothiopyran-4-ones as Possible
Schistosomicidal Agents. M. M. El-Kerdawy, A. A. El-Emam, H. I. El-Subbagh
and E. Abushanab. Monatsh. Chem. 120, 991-995 (1989).
11
54. Synthesis of Certain Antipyryl Derivatives as Potential Analgesics. M. A.
Moustafa, S. M. Bayomi, A. A. El-Emam and M. M. El-Kerdawy. Sci. Pharm.
57, 125-130 (1989).
55. Synthesis of Certain s-Triazoles and s-Triazolo[3,4-b]-1,3,4-thiadiazole
Derivatives of Expected Pharmacological Activities. H. M. Eisa, A. A. El-Emam,
M. A. Moustafa and M. M. El-Kerdawy. J. Chin. Chem. Soc. 35, 393-397 (1988).
56. Synthesis of Certain 1,3,4-Oxadiazoles, 1,2,4-Triazoles and 1,3,4-Thiadiazoles as
Potential Chemotherapeutic Agents. A. A. El-Emam, M. A. Moustafa and M. M.
El-Kerdawy. Pakistan J. Sci. Ind. Res. 31, 477-480 (1988).
57. Synthesis and Biological Testing of Certain -Thienyl and -Furyl Derivatives.
M. M. El-Kerdawy and A. A. El-Emam. J. Chem. Soc. Pak. 9, 285-293 (1987).
58. Synthesis and Antimicrobial Testing of Some 1,3,4-Oxadiazoline Derivatives. A.
A. El-Emam, M. A. Moustafa and M. M. El-Kerdawy. J. Chem. Soc. Pak. 9, 8792 (1987).
59. Spectroscopic Determination of the Major Metabolite of Phenytoin, 5-(pHydroxyphenyl)-5-phenylhydantoin in Human Urine. M. A. Moustafa, F. Belal
and A. A. El-Emam. J. Pharm. Belg. 42, 53-58 (1987).
60. Synthesis and Characterization of New Tetrazole Derivatives. M. A. Moustafa, H.
M. Eisa, A. A. El-Emam and M. M. El-Kerdawy. J. Pharm. Belg. 42, 38-43
(1987).
61. Synthesis of Certain Fused Pyrrolo Heterocycles. S. M. Bayomi, A. A. El-Emam,
M. A. Moustafa and M. M. El-Kerdawy. J. Taiwan Pharm. Assoc. 38, 53-59
(1986).
62. Synthesis of Substituted Mercapto-1,2,4-triazoles and Substituted 1,2,4-Triazol-5ylmercaptomethyl-1,3,4-oxadiazoles as Potential Antimicrobial Agents. M. Y.
Yousif, A. M. Ismaiel, A. A. El-Emam and M. M. El-Kerdawy. J. Chem. Soc.
Pak. 8, 183-190 (1986).
63. Synthesis of Certain Thiaxanthone Derivatives as Potential Schistosomicidal
Agents. M. M. El-Kerdawy, A. A. El-Emam and H. I. El-Subbagh. Arch. Pharm.
Res. 9, 25-28 (1986).
64. Novel Antimicrobial Agents Obtained by Addition of Maleimide Derivatives To
Thenaldehyde Azines or Schiff’s Bases. A. A. El-Emam, M. A. Moustafa, H. M.
Eisa and M. M. El-Kerdawy. Heterocycles 24, 1025-1029 (1986).
65. Synthesis of New Tetrazoles as Potential Anthelmintics. M. A. Moustafa, A. A.
El-Emam and M. M. El-Kerdawy. Proc. Ist. Int. Conf. Appl. Sci. Zagazig Univ.,
March 30-April 1, 1985, Vol. I, pp. 158-171.
66. Synthesis and Characterization of Certain -Thienyl Derivatives. M. M. ElKerdawy and A. A. El-Emam. Egypt. J. Pharm. Sci. 24, 201-210 (1983).