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Transcript 
Membrane receptors
membrane
Single-pass membrane receptors
membrane
Multi-pass membrane receptors
membrane
Ion channel membrane receptors
+
membrane
membrane
+
Ion channel membrane receptors
Receptor kinases
Kinase activities associated with receptors
intrinsic tyrosine
kinase activity
JAK tyrosine kinase
activity
G-protein-linked receptors
hormone
membrane
GTP
G-protein-linked receptors
a
GDP
g
b
G-protein-linked receptors
g
adapter
b
a
adenylate
cyclase
Insulin activation of glucose response
GLUT
P
P
PP PP
IRS-1
GLUT
Follicle Stimulating Hormone & Receptor
FSH subunit mRNAs
Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481
FSH subunit polypeptides
Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481
FSH
Fox, et al. Mol Endocrinol (2001) 15:378-389
FSH Receptor
mRNA
Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481
FSH Receptor
Huhtaniemi and Aittomaki (1998)
Eur.J.Endo. 138: 473– 481
FSH Receptor
(C, cysteine; S, serine; K, lysine; R, arginine; N, asparagine; A,
alanine; D, aspartic acid; F, phenylalanine).
Mann, et al. (2000) Biol. Reprod. 62: 1240-1247
FSH Receptor
Mann, et al. (2000) Biol. Reprod. 62: 1240-1247
FSH Receptor
Sohn, et al. (2003) J. Biol. Chem. 278: 47868 –47876
FSH Receptor
Sohn, et al. (2003) J. Biol. Chem.
278: 47868 –47876
FSH Receptor
Gay et al. (2006) Nature Reviews Immunology 6: 693-698
Natural mutations of FSH & Receptor
Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481
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