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Supplemental Table S1. Treatment with ARV-825 depletes BET protein BRD4, leading to
attenuation of BRD4 target genes such as c-MYC in sAML cells. SET2 cells were treated
with 250 nM of ARV-825 for 18 hours. Samples were prepared as biologic triplicates. At the end
of treatment, cells were harvested, lysed and utilized for reverse phase protein array (RPPA)
analysis. The table shows the absolute expression levels, log2 fold-change, and heatmap of
proteins altered > 25% (treated/untreated) and with a p-value < 0.05.
Supplemental Table S2. Effects of treatment with OTX015 on protein expressions in sAML
cells. SET2 cells were treated with 250 nM of OTX015 for 18 hours. Samples were prepared as
biologic triplicates. At the end of treatment, cells were harvested, lysed and utilized for reverse
phase protein array (RPPA) analysis. The table shows the absolute expression levels, log2 foldchange, and heatmap of proteins altered > 25% (treated/untreated) and with a p-value < 0.05.