Download Powerpoint - Blood Journal

A distinguishing gene signature shared by tumorinfiltrating Tie2-expressing monocytes, blood “resident”
monocytes, and embryonic macrophages suggests
common functions and developmental relationships
by Ferdinando Pucci, Mary Anna Venneri, Daniela Biziato, Alessandro Nonis, Davide
Moi, Antonio Sica, Clelia Di Serio, Luigi Naldini, and Michele De Palma
Blood
Volume 114(4):901-914
July 23, 2009
©2009 by American Society of Hematology
Gene expression profile of TEMs, TAMs, MDSCs, PMs, and ECs. (A) Flow cytometry analyses of
tumors grown subcutaneously in wild-type FVB mice (n = 4) and made into single-cell
suspensions shows that the majority of tumor-infiltrating myeloid cells (gated as ...
Ferdinando Pucci et al. Blood 2009;114:901-914
©2009 by American Society of Hematology
Confocal immunofluorescence analysis of mouse tumors identifies a distinguishing TEM
signature.
Ferdinando Pucci et al. Blood 2009;114:901-914
©2009 by American Society of Hematology
Flow cytometric analysis of tumors identifies a distinguishing TEM signature.
Ferdinando Pucci et al. Blood 2009;114:901-914
©2009 by American Society of Hematology
TEMs, like TAMs, are refractory to proinflammatory stimuli.
Ferdinando Pucci et al. Blood 2009;114:901-914
©2009 by American Society of Hematology
Circulating TEMs are bona fide hematopoietic cells distinct from circulating ECs and express a
resident monocyte phenotype.
Ferdinando Pucci et al. Blood 2009;114:901-914
©2009 by American Society of Hematology
Characterization of mouse embryonic/fetal macrophages.
Ferdinando Pucci et al. Blood 2009;114:901-914
©2009 by American Society of Hematology
A distinguishing TEM signature expressed by mouse embryonic/fetal macrophages.
Ferdinando Pucci et al. Blood 2009;114:901-914
©2009 by American Society of Hematology