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Planta Medica
Volume 74, Issue 2, February 2008, Pages 147-150
Cancer chemopreventive activity of terpenoid coumarins
from Ferula species
Iranshahi, M.af , Kalategi, F.a, Rezaee, R.a, Shahverdi, A.R.b, Ito, C.c, Furukawa, H.c, Tokuda, H.d, Itoigawa, M.e
a Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Mashhad University of
Medical Sciences (MUMS), Mashhad, Iran
b Department of Pharmaceutical Biotechnology, Pharmaceutical Science Research Center, Medical
Sciences/University of Tehran, Tehran, Iran
c Faculty of Pharmacy, Meijo University, Tempaku, Nagoya, Japan
d Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan
e Tokai Gakuen University, Nagoya, Japan
f Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Mashhad University of
Medical Sciences (MUMS), P.O.Box: 91775-1365, Mashhad, Iran
Abstract
Several natural products have been found to have anti-tumor promoting activity. In the present study, we carried out a
primary screening of ten terpenoid coumarins isolated from plants of the Ferula species, examining their possible
inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13acetate (TPA) in Raji cells. Auraptene (7-geranyloxycoumarin, 1) and umbelliprenin (7-farnesyloxycoumarin, 2) were
found to significantly inhibit EBV-EA activation and preserved the high viability of Raji cells, suggesting that they
might be valuable anti-tumor-promoting agents (IC 50 8.3 and 9.1 nM, respectively). Our findings revealed that the
presence of a prenyl moiety in the terpenoid coumarins plays an important role in anti-tumor promoting activity as
previously reported for xanthones, coumarins, flavonoids and phenylpropanoids. © Georg Thieme Verlag KG
Stuttgart.
Reaxys Database Information
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Author keywords
Anti-tumor promoting effect; Apiaceae; Cancer chemoprevention; Epstein-Barr virus activation assay; Ferula;
Terpenoid coumarins
Indexed Keywords
EMTREE drug terms: antineoplastic agent; auraptene; badrakemone; beta carotene; conferone; coumarin
derivative; curcumin; early antigen; Epstein Barr virus antigen; farnesiferol a; ferukrinone; feselol; galbanic acid;
herniarin; methylgalbanate; mogoltacin; phorbol 13 acetate 12 myristate; umbelliprenin; unclassified drug
EMTREE medical terms: antineoplastic activity; article; cancer prevention; cell viability; chemoprophylaxis;
controlled study; drug effect; drug isolation; drug mechanism; drug screening; Epstein Barr virus; fennel; Ferula
badrakema; Ferula flabelliloba; Ferula persica; Ferula szowitsiana; human; human cell; IC 50; medicinal plant; Raji
cell
MeSH: Anticarcinogenic Agents; Cell Line, Tumor; Coumarins; Ferula; Herpesvirus 4, Human; Humans; Lymphoma,
B-Cell; Plant Extracts; Terpenes
Medline is the source for the MeSH terms of this document.
Species Index: Apiaceae; Ferula; Human herpesvirus 4
Chemicals and CAS Registry Numbers: auraptene, 495-02-3; beta carotene, 7235-40-7; curcumin, 458-37-7;
galbanic acid, 3566-55-0; herniarin, 531-59-9; phorbol 13 acetate 12 myristate, 16561-29-8; umbelliprenin, 23838-177;Anticarcinogenic Agents; Coumarins; Plant Extracts; Terpenes
ISSN: 00320943 CODEN: PLMEASource Type: Journal Original language: English
DOI: 10.1055/s-2008-1034293 PubMed ID: 18240102Document Type: Article