Download Nutritional Status in HIV-Infected Drug Users in Hanoi

Poster No. 82
Title:
Nutritional Status in HIV-Infected Drug Users in Hanoi, Vietnam and Chennai, South India
Authors:
Kimberly Dong, Ramakrishnan Ramachandran, Hien Duc Nguyen, Thota Venkata Rao, Lien Trinh,
Tarun Bhatnagar, Dang Van Duong, Kartik Krishnan, M. Suresh Kumar, Mohan Gupte, Vijaya Kumari,
Heidi Sheehan, Hanh La, Alice Tang, Christine Wanke
Presented by:
Kimberly Dong
Departments:
Department of Public Health and Community Medicine, Tufts University School of Medicine; National Institute
of Epidemiology, Indian Council of Medical Research, Chennai, India; National Institute of Infectious and
Tropical Diseases, Hanoi, Vietnam; Hopers Foundation, Chennai, India
Abstract:
Background: Nutritional complications are frequent in HIV infection and in drug users (DU). Associated
morbidity suggests need for intervention.
Methods: We examined nutritional status of male DU in Hanoi, Vietnam (n=197) and Chennai, South India
(n=300) who were HIV-positive/HAART-naïve or HIV-negative. Asterisks in table highlight statistically
significant (p< 0.05) differences by HIV-status within site using t-tests.
Results: Participants in Hanoi had a mean age of 31, while mean age was 37 in Chennai. Thirty-one percent of
the DU in Hanoi had been incarcerated, as had 68% of DU in Chennai. Seventy-one percent of the DU in Hanoi
were married and 99% acknowledged heterosexual sex; in Chennai 41% were married and 91% were
heterosexual. DU in Hanoi was mostly heroin and in Chennai, heroin plus prescription drugs were common.
Malnutrition is common in DU regardless of HIV-status. BMI, percent body fat, total cholesterol were low.
HDL and protein intake were high in Hanoi, even with advanced HIV, but low in Chennai. Triglycerides were
elevated in Hanoi, but not in Chennai. Food insecurity was rare in Hanoi and common in Chennai.
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Poster No. 82
Nutritional status of drug users by HIV and Site
Hanoi
Hanoi
Chennai
Chennai
HIV+
HIV–
HIV+
HIV–
n=99
n=98
n=107
n=193
CD4 (mm3)
97 ± 68
NA
344 ± 188
NA
Total Chol (mg/dl)
149 ± 40*
179 ± 39*
131 ± 34*
152 ± 39*
TG mg/dl
175 ± 128
161 ± 114
95 ± 45*
90 ± 47*
HDL mg/dl
45.5 ± 20.5*
62.5 ± 15.2*
35 ± 11*
41 ± 11*
LDL mg/dl
71.0 ± 34.8*
86.7 ± 33.6
81 ± 22*
95 ± 28*
Insulin Res. QUICKI
0.423 ± 0.12
0.437 ± 0.16
0.365 ± 0.04
0.353 ± 0.05
QUICKI <0.357
26%
28%
37%*
54%*
Hepatitis B exposed†
100%
100%
92%
83%
Hepatitis C exposed
92%*
52%*
92%*
64%*
BMI (kg/m2)
19.1 ± 2.1*
20.5 ± 2.9*
18.6 ± 1.9*
19.1 ± 3.0*
BMI <18.5
40%*
24%*
52%
48%
Body fat %
11.2 ± 6.3
11.1 ± 10.2
6.5 ± 4.0*
7.9 ± 5.4*
Body fat kg
6.2 ± 4.0
6.9 ± 7.0
3.3 ± 2.4*
4.5 ± 3.8*
Energy intake (kcal)
2222*
1957*
2305
2592
Carbohydrate (g)
299*
238*
380
398
Protein (g)
102
92
59.3
65.7
Fat (g)
62
56
58*
71*
Fiber (g)
9.6*
7.9*
4.3
4.7
Clinical Laboratory Results
Body Composition
Dietary Intake‡
*: Difference significant within site
†: Definition of Hepatitis B exposed defined as positive to at least one: HBsAg; HBcAb; HBsAb
‡: Vietnam data based on 72 recalls for HIV+ and 90 recalls for HIV–
Conclusions: Vast differences in lipid abnormalities and food insecurity between countries emphasize that
interventions to improve nutritional and metabolic status need to be site specific.
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