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NAOSITE: Nagasaki University's Academic Output SITE
Title
Conformational studies on peptides having chiral five-membered ring
amino acid with two azido or triazole functional groups within the
sequence of Aib residues
Author(s)
Oba, Makoto; Kawabe, Naomi; Takazaki, Hiroomi; Demizu, Yosuke; Doi,
Mitsunobu; Kurihara, Masaaki; Suemune, Hiroshi; Tanaka, Masakazu
Citation
Tetrahedron, 70(46), pp.8900-8907; 2014
Issue Date
2014-11-18
URL
http://hdl.handle.net/10069/35165
Right
© 2014 Elsevier Ltd.; NOTICE: this is the author’s version of a work that
was accepted for publication in Tetrahedron. Changes resulting from the
publishing process, such as peer review, editing, corrections, structural
formatting, and other quality control mechanisms may not be reflected in
this document. Changes may have been made to this work since it was
submitted for publication. A definitive version was subsequently published
in Tetrahedron, 70, 46, (2014)
This document is downloaded at: 2017-08-12T07:43:44Z
http://naosite.lb.nagasaki-u.ac.jp
Conformational studies on peptides having chiral five-membered ring
amino acid with two azido or triazole functional groups within the
sequence of Aib residues
Makoto Obaa*, Naomi Kawabeb, Hiroomi Takazakib, Yosuke Demizuc, Mitsunobu Doid, Masaaki
Kuriharac, Hiroshi Suemuneb, Masakazu Tanakaa*
a
Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan
b
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
c
Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158-8501, Japan
d
Osaka University of Pharmaceutical Sciences, Osaka 569-1094, Japan
a)
b)
d)
Fig. S1.
c)
e)
CD spectra of a) pentapeptides (R = azide: 1; R = triazole: 2), b) pentapeptides (R =
azide: 3; R = triazole: 4), c) Boc-[(R,R)-Ac5cdN3-(Aib)2]n-OEt (n = 1, 3 mer: 5; n = 2, 6 mer: 6; n = 3,
9 mer: 7), d) azide compounds (pentapeptide 1; pentapeptide 3; amino acid 8), and d) triazole
compounds (pentapeptide 2; pentapeptide 4; amino acid 9) in TFE solution.
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