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FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly by Antonija Jurak Begonja, Karin M. Hoffmeister, John H. Hartwig, and Hervé Falet Blood Volume 118(8):2285-2295 August 25, 2011 ©2011 by American Society of Hematology Platelet counts and clearance. Antonija Jurak Begonja et al. Blood 2011;118:2285-2295 ©2011 by American Society of Hematology Macrophage depletion and microvesicle formation. Antonija Jurak Begonja et al. Blood 2011;118:2285-2295 ©2011 by American Society of Hematology In vivo and in vitro megakaryopoiesis. Antonija Jurak Begonja et al. Blood 2011;118:2285-2295 ©2011 by American Society of Hematology Altered thrombopoiesis in FlnA-null MKs. (A) Control and FlnA-null MK cultures with proplatelets on day 4 were visualized by immunofluorescence for β-tubulin. Antonija Jurak Begonja et al. Blood 2011;118:2285-2295 ©2011 by American Society of Hematology Microtubule coils in FlnA-null platelets. Antonija Jurak Begonja et al. Blood 2011;118:2285-2295 ©2011 by American Society of Hematology Protein expression in FlnA-null platelets and MKs. FlnA-null and control blood platelets (A) or MKs from day 3 cultures (B) were probed with fluorescein isothiocyanate-labeled antibodies for surface expression of GPIbα, GPIbβ, GPIX, GPV, and CD61 and analyz... Antonija Jurak Begonja et al. Blood 2011;118:2285-2295 ©2011 by American Society of Hematology Microvesiculation of FlnA-null platelets. Antonija Jurak Begonja et al. Blood 2011;118:2285-2295 ©2011 by American Society of Hematology
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