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Download 3169-3177 April 15, 2005
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Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1–dependent activation of PI-3K/Akt and regulation of Bcl-2 family members by Vidya Limaye, Xiaochun Li, Chris Hahn, Pu Xia, Michael C. Berndt, Mathew A. Vadas, and Jennifer R. Gamble Blood Volume 105(8):3169-3177 April 15, 2005 ©2005 by American Society of Hematology SK promotes endothelial cell survival. Vidya Limaye et al. Blood 2005;105:3169-3177 ©2005 by American Society of Hematology SK prevents EC apoptosis. Vidya Limaye et al. Blood 2005;105:3169-3177 ©2005 by American Society of Hematology SK regulates PECAM-1 expression and phosphorylation levels. Vidya Limaye et al. Blood 2005;105:3169-3177 ©2005 by American Society of Hematology PECAM-1 signaling is involved in SK-mediated cell survival. Vidya Limaye et al. Blood 2005;105:3169-3177 ©2005 by American Society of Hematology SK activates the PI-3K/Akt pathway but not the MAPK pathway. Vidya Limaye et al. Blood 2005;105:3169-3177 ©2005 by American Society of Hematology Inhibition of the PI-3K/Akt pathway blocks SK-induced cell survival. Vidya Limaye et al. Blood 2005;105:3169-3177 ©2005 by American Society of Hematology SK regulates proteins involved in apoptosis. Vidya Limaye et al. Blood 2005;105:3169-3177 ©2005 by American Society of Hematology
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