Download Pathology MCQs May 29, 2012

Pathology MCQs May 29, 2012
Kathryn Clark
Viral Hepatitis
1. Hepatitis A (pg 844)
a. is a benign, self-limiting disease.
b. has a mean incubation period of 1-4 months.
c. frequently causes fulminant hepatitis.
d. IgM is not a reliable marker of acute infection.
2. Hepatitis B can produce all of the following EXCEPT (pg 845/849)
a. acute hepatitis
b. helper-independent latent infection
c. non-progressive chronic hepatitis
d. an asymptomatic carrier state
3. Which of the following is NOT a single stranded RNA virus (pg 844)
a. HAV
b. HBV
c. HCV
d. HDV
4. Which is the correct match of mode of transmission with geographical areas
for Hepatitis B (pg 845)
a. High prevalence regions – unprotected intercourse
b. Low prevalence regions – perinatal transmission
c. Intermediate prevalence regions – horizontal transmission
d. High prevalence regions – transfusion related spread
5. Which is INCORRECT with regards to hepatitis C (pg 847/849)
a. HCV is a major cause of liver disease worldwide.
b. Progression to chronic liver disease occurs in the majority of HCVinfected individuals.
c. HCV is the most common indication for liver transplantation in the
US.
d. HCV has a high mortality rate among pregnant women.
6. Hepatitis D (pg 848/849)
a. is dependant for its life cycle on HBV.
b. coinfection of HDV + HBV is clinically distinguishable from acute
HBV.
c. has fecal-oral mode of transmission
d. Vaccination for HBV does not prevent HDV infection.
7. Hepatitis E (pg 844/849)
a. is a partially double stranded DNA virus.
b. is diagnosed via PCR for HEV RNA and detection of serum IgM and
IgG antibodies.
c. frequency of chronic liver disease is 80%
d. route of transmission is sexual contact
8. Clinicopathologic syndromes of viral hepatitis do NOT include (pg 850)
a. acute asymptomatic infection with recovery
b. acute symptomatic hepatitis with recovery
c. chronic hepatitis with progression to cirrhosis
d. fulminant hepatitis with recovery
9. With regard to HIV and chronic hepatits which is INCORRECT (pg 850)
a. have similar transmission mode and high-risk patient population.
b. co-infection is becoming a common clinical problem.
c. Among HIV patients, 30% are infected with HBV.
d. Chronic HBV/HCV infection is a leading cause of morbidity and
mortality for HIV-infected patients.
10. The major routes of transmission of HIV are (pg 236)
a. Sexual transmission
b. Parenteral transmission
c. Mother-to-infant transmission
d. Fecal-oral transmission
11. HIV 2 is most commonly associated with AIDS in (pg 237)
a. USA
b. Europe
c. West Africa
d. Central Africa
12. The HIV virus core contains all EXCEPT (pg 237)
a. major caspid protein p24
b. nucleocaspid protein p7/p9
c. 3 copies of genomic DNA
d. 3 viral enzymes
13. With regards to HIV which statement is INCORRECT (pg 238-240)
a. The two major targets of HIV infection are the immune system and the
central nervous system.
b. HIV infects cells by using the CD4 molecule as a receptor.
c. The initial step in HIV infection is gp41 membrane penetration.
d. HIV colonises the lyphoid organs.
14. Patients with AIDS may present with the following EXCEPT (pg 225-248)
a. Opportunistic infections such as candida and cytomegalovirus.
b. Tumors such as Kaposi sarcoma.
c. Lymphomas.
d. Amyloidosis
15. Antiretroviral drug therapy for HIV infection (pg 248)
a. Eradicates HIV.
b. Once the virus is suppressed, progressive loss of CD4+ T cells is
halted.
c. Over years, the peripheral CD4+ T cell count slowly decreases.
d. Use of these drugs has not affected death rates from AIDS.
Answers
1. a
2. b
3. b
4. c
5. d
6. a
7. b
8. d
9. c
10. d
11. c
12. c
13. c
14. d
15. b