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Effect of Aldosterone-Producing Adenoma on Endothelial
Function and Rho-Associated Kinase Activity in Patients
With Primary AldosteronismNovelty and Significance
by Takeshi Matsumoto, Kenji Oki, Masato Kajikawa, Ayumu Nakashima, Tatsuya
Maruhashi, Yumiko Iwamoto, Akimichi Iwamoto, Nozomu Oda, Takayuki Hidaka,
Yasuki Kihara, Nobuoki Kohno, Kazuaki Chayama, Chikara Goto, Yoshiki Aibara,
Kensuke Noma, James K. Liao, and Yukihito Higashi
Hypertension
Volume 65(4):841-848
March 11, 2015
Copyright © American Heart Association, Inc. All rights reserved.
Flow-mediated vasodilation (A) and nitroglycerine-induced vasodilation (B) in patients with
essential hypertension (EHT), patients with aldosterone-producing adenoma (APA), and patients
with idiopathic hyperaldosteronism (IHA).
Takeshi Matsumoto et al. Hypertension. 2015;65:841-848
Copyright © American Heart Association, Inc. All rights reserved.
Representative western blot analysis for phospho myosin–binding subunit (p-MBS), total
myosin-binding subunit (t-MBS), and actin in peripheral blood leukocytes in patients with
essential hypertension (EHT), patients with aldosterone-producing adenoma (APA), and patients
with idiopathic hyperaldosteronism (IHA) (A).
Takeshi Matsumoto et al. Hypertension. 2015;65:841-848
Copyright © American Heart Association, Inc. All rights reserved.
Flow-mediated vasodilation (A) and Rho-associated kinases (ROCK) activity (B) before and after
adrenalectomy in patients with aldosterone-producing adenoma.
Takeshi Matsumoto et al. Hypertension. 2015;65:841-848
Copyright © American Heart Association, Inc. All rights reserved.
Relationships between flow-mediated vasodilation and plasma aldosterone concentration (A)
and the aldosterone:renin ratio (B) and relationship between Rho-associated kinases (ROCK)
and plasma aldosterone concentration (C) and the aldosterone:renin ratio (D) before and after
adrenolectomy in patients with aldosterone-producing adenoma. p-MBS indicates phospho
myosin–binding subunit; and t-MBS, total myosin-binding subunit.
Takeshi Matsumoto et al. Hypertension. 2015;65:841-848
Copyright © American Heart Association, Inc. All rights reserved.
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