Download Streptococcus pneumoniae sepsis in newborns associated with

Streptococcus pneumoniae sepsis in newborns associated with vertical transmission: description of two cases Cane A1, Capelli C2, Acha L2, D´Elizalde M2, Depardo R6, Garrone M6, Musante G2, Casanueva E1, Rocca Rivarola M3, Fossati S5,Vilches V4, Gagetti P5, Corso A5. 1. Pediatrics Infectious Diseases, 2.Neonatology,3. Pediatrics, 4.Microbiology Hospital Universitario Austral‐ Pilar ; 5. INEI‐ANLIS “Dr. C. Malbrán”–Argentina, 6.Hosp. Municipal de Morón Background and aims: Streptococcus pneumoniae (Spn) is an important pathogen, however, neonatal infections due to this organism are rare. Here we report two cases of early‐onset pneumococcal septicemia with documented carriage of Spn in the mother´s genital tract. Methods and results: Newborns (case 1: 39 weeks; case 2: 32 weeks) presented neonatal sepsis in the first 36 hours of life. Case 1 Case 2 No Yes Sepsis‐Meningitis Sepsis No No Spn isolated in newborns CSF and Blood Blood Spn isolated in mothers Cervix‐ Vagina Ovular membranes Spn serotype 5 3 Spn PFGE profile: newborn and mother A B Cefotaxime Cefotaxime Premature rupture membranes Newborn sign and symptoms Maternal symptoms Treatment Isolates from newborns and mothers were serotyped by Quellung reaction. Antimicrobial susceptibility was determined by agar dilution according CLSI and clonal relationship by SmaI‐
PFGE. Isolates were susceptible to all the antibiotics tested. Isolates from newborns and mothers were, in each case, genetically indistinguishable by PFGE. Babies improved slowly with therapy and they were discharged without clinical abnormalities. Conclusions: These cases demonstrate that although pneumococcal neonatal sepsis is infrequent, the colonization of the maternal genital tract by this pathogen may lead to septicemia in the newborn.