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Contents Chapter 1 Introduction and aim of the study Chapter 2 Oral cancer; some aspects of the etiology, diagnosis, histopathology and staging Chapter 3 The clinical relevance of epithelial dysplasia in the surgical margins of tongue and floor of mouth squamous cell carcinoma: an analsyis of 37 patients 9 13 23 J Oral Pathol Med 2002; 31:11-15 Chapter 4 The status of the deep surgical margins in tongue and floor of mouth squamous cell carcinoma and risk of local recurrence; analysis of 68 patients 33 Int J Oral Maxillofac Surg 2004; 33:146-149 Chapter 5 Malignancy grading is no better than conventional histopathological grading in small squamous cell carcinoma of tongue and floor of mouth: retrospective study in 128 patients 43 J Oral Pathol Med 2009; 38: 343-347 Chapter 6 Patients with oral cancer developing from pre-existing oral leukoplakia: do they do better than those with de novo oral cancer? 57 J Oral Pathol Med 2008; 37: 134-136 Chapter 7 Oral cancer trends in a single head-and-neck cancer center in the Netherlands; decline in T-stage at the ime of admission 65 Med Oral Patol Oral Cir Bucal 2011; 16: e914-e918 Chapter 8 Summary and conclusions 75 Chapter 9 Samenvatting en conclusies 81 Dankwoord Curriculum Vitae 87 91