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Table 1b, showing the mean value, standard deviation, maximum and
minimum and p value for each parameter for the patients with normal
(Group A) cardiac R2* compared to those with abnormal (Group B) and
number of patients on whom the parameters were available. The p value
shown is dependent on the F test – i.e. if the latter is significant (<0.05) then
the p value is that derived testing with unequal variance, if not significant
the p value is that with equal variance. The bold P value indicates those
parameters that have a significant relationship to cardiac R2*.
Parameter
Age
Age start chelation.
Ferritin at start of
chelation
Maximum Ferritin
Minimum Ferritin
Mean Ferritin
Most recent Ferritin
Red Cell
Consumption
Compliance
IEF
Hep R2*
EF
EDVI
ESVI
SVI
•
•
No.
of
pts
50
50
50
Mean
Group A
Standard
Deviation
No.
of pts
Mean
Standard
Deviation
Group B
Difference
Comparison
Bonferroni
Correction
p value*
0.0062
0.062
0.13
0.15
p
26.24
6.8
3320
5.6
3.4
2460
109
109
107
28.99
7.8
3942
5.9
3.9
2547
-2.75
-1.0
-622
50
50
50
50
50
6167
1137
2422
2428
194
2496
915
1474
1654
36
109
109
109
109
109
6946
1355
3163
3214
196
3061
909
2060
2306
37
-779
-218
-741
-786
-2
0.12
0.16
0.011
0.016
0.76
0.11
0.16
-
50
50
46
45
24
24
24
267
1269
537
69.6
70.3
20.8
48.36
50
525
446
6.0
19.7
8.38
15.8
97
97
98
101
62
62
62
243
1833
790
64
70.8
26.48
44.5
51
826
684
11.6
19.8
13.5
11.9
24
-564
-253
-5.6
0.5
-5.68
3.86
0.0064
<0.00001
0.0092
0.0003
0.9
0.0255
0.28
0.064
<0.00001
0.092
-
*Bonferroni correction was applied to reduce the potential of a chance finding
taking the eleven parameters Age- Hep R2* and analyzing only for those that
were originally significant.
12 were referred for an MRI as abnormal Left Ventricular Ejection Fraction found
on echocardiogram. Remainder was referred because the investigation had
become routine in the clinic on a first come first served basis. Group A are the
patients who had normal R2* <40 sec-1 and Group B are those with cardiac iron
and R2* ≥ 40 sec-1.
2
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