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PROGRAM IN EPITHELIAL BIOLOGY SEMINARS 2007-08 Fridays from 9-10 am CCSR 4 Floor Conference Room (4205) th OCTOBER 5 John Rinn (Chang Lab) – “Epigenetic maintenance of a dermal HOX code by large ncRNAs” 12 Jeff Axelrod (Associate Professor of Pathology) – “Mechanisms of planar cell polarity signaling: from flies to vertebrates” 19 Amy Truong (Khavari Lab) – “p63 and p53 Antagonism in Control of Keratinocyte Proliferation” 26 Gill Bejerano (Assistant Professor of Developmental Biology and Computer Science) "Mammalian DNA Persistence" NOVEMBER 2 Todd Ridky (Khavari Lab) - "Defining mechanisms promoting human squamous cell carcinoma invasion" 9 Ivette Estay (Oro Lab) - "Characterization of a novel degradation signal in the Gli1 transcription factor" 16 Jason Reuter (Khavari Lab) – “Ras-Induced Epithelial Tumorigenesis” 23 NO SEMINAR – THANKSGIVING HOLIDAY 30 Wei-Meng Woo (Oro Lab) – “Hedgehog controls hair follicle regeneration through a novel dermal signaling pathway” DECEMBER 7 PJ Utz (Assoc. Prof. of Immunology and Rheumatology) – “Protein Array Profiling and Lymphocytes” 14 Zurab Siprashvili (Khavari Lab) - "Molecular Therapeutic Approaches for Human Recessive Dystrophic Epidermolysis Bullosa" 21 HOLIDAY BREAK 28 HOLIDAY BREAK JANUARY 4 NO SEMINAR 11 Katie Jameson (Khavari Lab) – “Erk/MAPK-Interacting Proteins in Epidermal Homeostasis and Tumorigenesis” 18 Tiara Kawahara (Chang Lab) - "Control of NF-kB Activity by a Mammalian Sir2 Regulator" 25 Roger Kaspar (Founder and CEO, TransDerm) – “Development of therapeutic siRNAs for treatment of skin disorders including pachyonychia congenita” FEBRUARY 1 No Seminar 8 No Seminar 15 Gabe Quinones (Oro Lab) – “Interpreting local migratory signals through actin regulatory molecules” 22 Sruthi Tallapragada (Marinkovich Lab) CANCELLED 29 John Garcia (Khavari Lab) - “Extracellular matrix signaling in epithelial tumorigenesis” CANCELLED MARCH 7 Jordon Wang (Chang Lab) - "Non-coding RNA HOTAIR and its regulation of Polycombmediated Histone marks" 14 Radhika Atit, Ph.D. (Assistant Professor, Dept. of Biology and Depts. of Genetics/Dermatology, Case Western Reserve University) – “Wnt signaling and dermal development” – CANCELLED; MOVED TO MAY 23 21 Adam Adler (Chang Lab) – “Mechanisms underlying large-scale gene expression changes in cancer and aging” 28 George Sen (Khavari Lab) - "The Role of PCG proteins in Epidermal Differentiation" APRIL 4 Dave Wong (Chang Lab) – “Toward creating a model system of epidermal cancer stem cells” 11 John VanArnam (Oro Lab) - "Proteasomal Destruction of Shh and Wnt Signaling Mediators Controls Hair Cycling" 18 Mark Tran (Marinkovich Lab) - Targeting laminin-322 in SCC carcinogenesis” CANCELLED 25 Jean Tang (UC San Francisco, Ervin Epstein Lab ) – “Of mice and men: Targeting the hedgehog pathway for prevention of BCC” MAY 2 Marina Bershteyn (Oro Lab) - "Defining MIM/Mtss1 function in Sonic Hedgehog Signaling" 9 Markus Kretz (Khavari Lab) - "Differential expression of long noncoding RNAs during differentiation and neoplasia of human epidermis" 16 NO SEMINAR – SID MEETING 23 Radhika Atit, Ph.D. (Assistant Professor, Dept. of Biology and Depts. of Genetics/Dermatology, Case Western Reserve University) – “Wnt signaling and dermal development” 30 Kelly McGowan - "The dark side of p53" JUNE 6 Mindy DeRouen (Oro) – “Non-cell autonomous regulators of Shh target gene induction in BCC”